{ "uniprot_canonical_ac": "P05186-1", "uniprot_ac": "P05186", "uniprot_id": "PPBT_HUMAN", "mass": { "chemical_mass": 57305.0, "monoisotopic_mass": 57305.0 }, "refseq": { "ac": "NP_000469", "name": "alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein", "summary": "This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469" }, "gene_names": [ { "name": "ALPL", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P05186", "id": "P05186" }, { "name": "ALPL", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469", "id": "NP_000469" }, { "name": "AP-TNAP; APTNAP; HOPS; HPPA; HPPC; HPPI; HPPO; TNALP; TNAP; TNS-ALP; TNSALP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469", "id": "NP_000469" } ], "protein_names": [ { "name": "Alkaline phosphatase, tissue-nonspecific isozyme", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P05186" }, { "name": "3.1.3.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "3.9.1.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "AP-TNAP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "Alkaline phosphatase liver/bone/kidney isozyme", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "Phosphoamidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "Phosphocreatine phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "TNS-ALP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "TNSALP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P05186" }, { "name": "alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469", "id": "NP_000469" }, { "name": "liver/bone/kidney-type alkaline phosphatase; tissue-nonspecific ALP; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; tissue non-specific alkaline phosphatase; phosphoamidase; phosphocreatine phosphatase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469", "id": "NP_000469" } ], "function": [ { "annotation": "Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (PubMed:12162492, PubMed:23688511, PubMed:25982064). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (PubMed:12162492, PubMed:2220817). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:23688511, PubMed:25982064). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (PubMed:2220817, PubMed:20049532). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (PubMed:28448526). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186#function" }, { "database": "UniProtKB", "id": "P09242", "url": "https://www.uniprot.org/uniprot/P09242#function" }, { "database": "PubMed", "id": "23688511", "url": "https://glygen.org/publication/PubMed/23688511" }, { "database": "PubMed", "id": "25982064", "url": "https://glygen.org/publication/PubMed/25982064" }, { "database": "PubMed", "id": "2220817", "url": "https://glygen.org/publication/PubMed/2220817" }, { "database": "PubMed", "id": "12162492", "url": "https://glygen.org/publication/PubMed/12162492" }, { "database": "PubMed", "id": "20049532", "url": "https://glygen.org/publication/PubMed/20049532" }, { "database": "PubMed", "id": "28448526", "url": "https://glygen.org/publication/PubMed/28448526" } ] }, { "annotation": "Association between changes in serum alkaline phosphatase levels and radiographic progression in ankylosing spondylitis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469" }, { "database": "PubMed", "id": "37277451", "url": "https://glygen.org/publication/PubMed/37277451" } ] }, { "annotation": "Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant.", "evidence": [ { "database": "RefSeq", "id": "NP_000469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469" }, { "database": "PubMed", "id": "37351650", "url": "https://glygen.org/publication/PubMed/37351650" } ] }, { "annotation": "Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469" }, { "database": "PubMed", "id": "38234425", "url": "https://glygen.org/publication/PubMed/38234425" } ] }, { "annotation": "This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_000469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469" } ] } ], "disease": [ { "disease_id": "DOID:0110913", "recommended_name": { "id": "DOID:0110913", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110913", "name": "adult hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in a heterozygous or compound heterozygous mutation of the ALPL gene on chromosome 1p36.12." }, "synonyms": [ { "id": "DOID:0110913", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110913", "name": "mild hypophosphatasia", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "obsolete adult hypophosphatasia", "description": "OBSOLETE. Adult hypophosphatasia (A-HPP) is a mildform of hypophosphatasia characterized by osteomalacia, chondrocalcinosis, osteoarthropathy, stress fractures duringmiddle age, and dental anomalies." }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "adult Rathburn disease", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "adult phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "hypophosphatasia of adults", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "obsolete adult hypophosphatasia", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "hypophosphatasia, ADULT", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "hypophosphatasia, mild", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "mild hypophosphatasia", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "odontohypophosphatasia", "description": "" }, { "id": "MIM:146300", "resource": "MIM", "url": "https://www.omim.org/entry/146300", "name": "Hypophosphatasia", "description": "Hypophosphatasia" } ], "evidence": [ { "id": "146300", "database": "MIM", "url": "https://www.omim.org/entry/146300" } ] }, { "disease_id": "DOID:0110914", "recommended_name": { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "infantile hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in homozygous or compound heterozygosity mutation in the gene encoding tissue-nonspecific alkaline phosphatase (ALPL) on chromosome 1p36." }, "synonyms": [ { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "Hops", "description": "" }, { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "obsolete infantile hypophosphatasia", "description": "OBSOLETE. Infantile hypophosphatasia (I-HPP) is a very rare, severe form of hypophosphatasia characterized by infantile rickets without elevated serum alkaline phosphatase (ALP) activity and a wide range of clinical manifestations due to hypomineralization." }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "HOPS", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "infantile Rathburn disease", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "infantile phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "obsolete infantile hypophosphatasia", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "hypophosphatasia, infantile", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "hypophosphatasia, perinatal lethal", "description": "" }, { "id": "MIM:241500", "resource": "MIM", "url": "https://www.omim.org/entry/241500", "name": "Hypophosphatasia, infantile", "description": "Hypophosphatasia, infantile" } ], "evidence": [ { "id": "241500", "database": "MIM", "url": "https://www.omim.org/entry/241500" } ] }, { "disease_id": "DOID:0110915", "recommended_name": { "id": "DOID:0110915", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110915", "name": "childhood hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in an autosomal recessive mutation of the ALPL gene on chromosome 1p36.12." }, "synonyms": [ { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "obsolete childhood hypophosphatasia", "description": "OBSOLETE. Childhood-onset hypophosphatasia is a rare, mildform of hypophosphatasia characterized by onset after six months of age and widely variable clinical features from low bone mineral density for age, to unexplained fractures,skeletal deformities,and rickets with short stature and waddling gait." }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "childhood-onset Rathburn disease", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "childhood-onset phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "hypophosphatasia of childhood", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "obsolete childhood hypophosphatasia", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "pediatric hypophosphatasia", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "childhood-onset hypophosphatasia", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "hypophosphatasia, childhood", "description": "" }, { "id": "MIM:241510", "resource": "MIM", "url": "https://www.omim.org/entry/241510", "name": "Hypophosphatasia, childhood", "description": "Hypophosphatasia, childhood" } ], "evidence": [ { "id": "241510", "database": "MIM", "url": "https://www.omim.org/entry/241510" } ] } ], "snv": [ { "evidence": [ { "id": "rs745841670", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745841670" }, { "id": "rs745841670", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745841670" }, { "id": "rs745841670", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs745841670#frequency_tab" }, { "id": "rs745841670", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs745841670" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 142, "end_pos": 142, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->NTI).", "chr_id": "1", "chr_pos": "21563237", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T142", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765011829", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765011829" }, { "id": "rs765011829", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765011829" }, { "id": "rs765011829", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs765011829#frequency_tab" }, { "id": "rs765011829", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765011829" }, { "id": "23797736", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23797736" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 192, "end_pos": 192, "sequence_org": "M", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NEM->NET).", "chr_id": "1", "chr_pos": "21564143", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "M192", "disease": [ { "disease_id": "DOID:0110914", "recommended_name": { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "infantile hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in homozygous or compound heterozygosity mutation in the gene encoding tissue-nonspecific alkaline phosphatase (ALPL) on chromosome 1p36." }, "synonyms": [ { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "Hops", "description": "" }, { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "obsolete infantile hypophosphatasia", "description": "OBSOLETE. Infantile hypophosphatasia (I-HPP) is a very rare, severe form of hypophosphatasia characterized by infantile rickets without elevated serum alkaline phosphatase (ALP) activity and a wide range of clinical manifestations due to hypomineralization." }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "HOPS", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "infantile Rathburn disease", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "infantile phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "obsolete infantile hypophosphatasia", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "hypophosphatasia, infantile", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "hypophosphatasia, perinatal lethal", "description": "" }, { "id": "MIM:241500", "resource": "MIM", "url": "https://www.omim.org/entry/241500", "name": "Hypophosphatasia, infantile", "description": "Hypophosphatasia, infantile" } ] } ], "keywords": [ "ebi", "somatic", "disease" ] }, { "evidence": [ { "id": "rs1240343208", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1240343208" }, { "id": "rs1240343208", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1240343208" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 230, "end_pos": 230, "sequence_org": "N", "sequence_mut": "H", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NKT->HKT).", "chr_id": "1", "chr_pos": "21568143", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N230", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs781272386", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781272386" }, { "id": "rs781272386", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781272386" }, { "id": "rs781272386", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781272386" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 272, "end_pos": 272, "sequence_org": "R", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRT->NPT).", "chr_id": "1", "chr_pos": "21570327", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R272", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs148405563", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148405563" }, { "id": "rs148405563", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148405563" }, { "id": "rs148405563", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148405563#frequency_tab" }, { "id": "rs148405563", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148405563" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 273, "end_pos": 273, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRT->NRM).", "chr_id": "1", "chr_pos": "21570330", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T273", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs148405563", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148405563" }, { "id": "rs148405563", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148405563" }, { "id": "rs148405563", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs148405563#frequency_tab" }, { "id": "rs148405563", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs148405563" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 273, "end_pos": 273, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRT->NRR).", "chr_id": "1", "chr_pos": "21570330", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T273", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs146908399", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146908399" }, { "id": "rs146908399", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146908399" }, { "id": "rs146908399", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146908399#frequency_tab" }, { "id": "rs146908399", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146908399" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 305, "end_pos": 305, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->NVM).", "chr_id": "1", "chr_pos": "21573716", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T305", "disease": [ { "disease_id": "DOID:0110913", "recommended_name": { "id": "DOID:0110913", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110913", "name": "adult hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in a heterozygous or compound heterozygous mutation of the ALPL gene on chromosome 1p36.12." }, "synonyms": [ { "id": "DOID:0110913", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110913", "name": "mild hypophosphatasia", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "obsolete adult hypophosphatasia", "description": "OBSOLETE. Adult hypophosphatasia (A-HPP) is a mildform of hypophosphatasia characterized by osteomalacia, chondrocalcinosis, osteoarthropathy, stress fractures duringmiddle age, and dental anomalies." }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "adult Rathburn disease", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "adult phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "hypophosphatasia of adults", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "obsolete adult hypophosphatasia", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "hypophosphatasia, ADULT", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "hypophosphatasia, mild", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "mild hypophosphatasia", "description": "" }, { "id": "MONDO:0007798", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007798", "name": "odontohypophosphatasia", "description": "" }, { "id": "MIM:146300", "resource": "MIM", "url": "https://www.omim.org/entry/146300", "name": "Hypophosphatasia", "description": "Hypophosphatasia" } ] }, { "disease_id": "DOID:0110915", "recommended_name": { "id": "DOID:0110915", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110915", "name": "childhood hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in an autosomal recessive mutation of the ALPL gene on chromosome 1p36.12." }, "synonyms": [ { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "obsolete childhood hypophosphatasia", "description": "OBSOLETE. Childhood-onset hypophosphatasia is a rare, mildform of hypophosphatasia characterized by onset after six months of age and widely variable clinical features from low bone mineral density for age, to unexplained fractures,skeletal deformities,and rickets with short stature and waddling gait." }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "childhood-onset Rathburn disease", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "childhood-onset phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "hypophosphatasia of childhood", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "obsolete childhood hypophosphatasia", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "pediatric hypophosphatasia", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "childhood-onset hypophosphatasia", "description": "" }, { "id": "MONDO:0009428", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009428", "name": "hypophosphatasia, childhood", "description": "" }, { "id": "MIM:241510", "resource": "MIM", "url": "https://www.omim.org/entry/241510", "name": "Hypophosphatasia, childhood", "description": "Hypophosphatasia, childhood" } ] }, { "disease_id": "DOID:0110914", "recommended_name": { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "infantile hypophosphatasia", "description": "A hypophosphatasia that has_material_basis_in homozygous or compound heterozygosity mutation in the gene encoding tissue-nonspecific alkaline phosphatase (ALPL) on chromosome 1p36." }, "synonyms": [ { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "Hops", "description": "" }, { "id": "DOID:0110914", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110914", "name": "phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "obsolete infantile hypophosphatasia", "description": "OBSOLETE. Infantile hypophosphatasia (I-HPP) is a very rare, severe form of hypophosphatasia characterized by infantile rickets without elevated serum alkaline phosphatase (ALP) activity and a wide range of clinical manifestations due to hypomineralization." }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "HOPS", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "infantile Rathburn disease", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "infantile phosphoethanolaminuria", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "obsolete infantile hypophosphatasia", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "hypophosphatasia, infantile", "description": "" }, { "id": "MONDO:0009427", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009427", "name": "hypophosphatasia, perinatal lethal", "description": "" }, { "id": "MIM:241500", "resource": "MIM", "url": "https://www.omim.org/entry/241500", "name": "Hypophosphatasia, infantile", "description": "Hypophosphatasia, infantile" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs751977466", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs751977466" }, { "id": "rs751977466", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs751977466" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 395, "end_pos": 395, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSI->NST).", "chr_id": "1", "chr_pos": 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"PubMed", "id": "25775211", "url": "https://glygen.org/publication/PubMed/25775211" } ] }, { "start_pos": 291, "end_pos": 291, "sequence_org": "E", "sequence_mut": "A", "comment": "Reduced alkaline phosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" }, { "database": "PubMed", "id": "25775211", "url": "https://glygen.org/publication/PubMed/25775211" } ] }, { "start_pos": 306, "end_pos": 306, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolished alkaline phosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" }, { "database": "PubMed", "id": "25775211", "url": "https://glygen.org/publication/PubMed/25775211" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "88.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "42.98", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "58.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "69.47", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "69.3", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": 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"database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "81.28", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "84.62", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P05186", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05186" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": 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"MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", 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"id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P05186", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05186" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P05186", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05186" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "common_name": "Human" } ], "gene": [ { "name": "ALPL", "url": "https://www.uniprot.org/uniprot/P05186", "locus": { "chromosome": "1", "start_pos": 21578410, "end_pos": 21509397, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000162551", "url": "https://www.ensembl.org/id/ENSG00000162551" } ] } } ], "crossref": [ { "id": "ENSG00000162551", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162551", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.1.3.1", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.1&UniProtAcc=P05186", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd16012", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16012", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL5979", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL5979", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "ALPL", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ALPL", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "249", "url": "https://www.ncbi.nlm.nih.gov/gene/249", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1916", "url": "https://glyconnect.expasy.org/browser/proteins/1916", "database": "GlyConnect", "categories": [ "Glycoproteomics", "Glycan" ] }, { "id": "438", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=438", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P05186", "url": "https://www.ebi.ac.uk/intact/interactors/id:P05186*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001952", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001952", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017850", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017850", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018299", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018299", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:249", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:249", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "146300", "url": "http://www.omim.org/entry/146300", "database": "MIM", "categories": [ "Other" ] }, { "id": "171760", "url": "http://www.omim.org/entry/171760", "database": "MIM", "categories": [ "Other" ] }, { "id": "241500", "url": "http://www.omim.org/entry/241500", "database": "MIM", "categories": [ "Other" ] }, { "id": "241510", "url": "http://www.omim.org/entry/241510", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P05186", "url": "https://www.nextprot.org/entry/NX_P05186", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P05186", "url": "https://oglcnac.org/atlas/detail/P05186", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "P05186", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P05186", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "RIMSKGM", "url": "https://omabrowser.org/oma/group/RIMSKGM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "35876at2759", "url": "http://www.orthodb.org/?query=35876at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11596", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11596", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11596:SF74", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11596:SF74", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "7YIV", "url": "https://www.rcsb.org/structure/7YIV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7YIW", "url": "https://www.rcsb.org/structure/7YIW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7YIX", "url": "https://www.rcsb.org/structure/7YIX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00245", "url": "http://pfam.xfam.org/family/PF00245", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P05186", "url": "https://pharos.nih.gov/targets/P05186", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P05186", "url": "http://purl.obolibrary.org/obo/PR_P05186", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_000469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000469", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12977", "url": "https://www.rhea-db.org/rhea/12977", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "15017", "url": "https://www.rhea-db.org/rhea/15017", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "16089", "url": "https://www.rhea-db.org/rhea/16089", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "20533", "url": "https://www.rhea-db.org/rhea/20533", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "24576", "url": "https://www.rhea-db.org/rhea/24576", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29375", "url": "https://www.rhea-db.org/rhea/29375", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "61436", "url": "https://www.rhea-db.org/rhea/61436", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B1ANL0", "url": "https://www.uniprot.org/uniprot/B1ANL0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1ANL0-1", "url": "https://www.uniprot.org/uniprot/B1ANL0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05186-1", "url": "https://www.uniprot.org/uniprot/P05186-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05186-2", "url": "https://www.uniprot.org/uniprot/P05186-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P05186-3", "url": "https://www.uniprot.org/uniprot/P05186-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF", "length": 524, "header": "sp|P05186-1|PPBT_HUMAN Isoform 1 of Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 CANONICAL=P05186-1" }, "isoforms": [ { "isoform_ac": "B1ANL0-1", "url": "", "sequence": { "sequence": "XHSHFIWNRTELLTLDPHNVDYLLGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF", "length": 216, "header": "tr|B1ANL0-1|PPBT_HUMAN Computationally mapped isoform of Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=2 CANONICAL=P05186-1" }, "locus": { "chromosome": "1", "start_pos": 21577646, "end_pos": 21570303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374830.2", "url": "https://www.ensembl.org/id/ENST00000374830.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000363963.2", "url": "https://www.ensembl.org/id/ENSP00000363963.2" } ] } }, { "isoform_ac": "P05186-1", "url": "", "sequence": { "sequence": "MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF", "length": 524, "header": "sp|P05186-1|PPBT_HUMAN Isoform 1 of Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 CANONICAL=P05186-1" }, "locus": { "chromosome": "1", "start_pos": 21577645, "end_pos": 21554082, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374840.8", "url": "https://www.ensembl.org/id/ENST00000374840.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000363973.3", "url": "https://www.ensembl.org/id/ENSP00000363973.3" } ] } }, { "isoform_ac": "P05186-2", "url": "", "sequence": { "sequence": "MPWSFRSSTPTWLRMSSCSWEMTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF", "length": 447, "header": "sp|P05186-2|PPBT_HUMAN Isoform 2 of Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 CANONICAL=P05186-1" }, "locus": { "chromosome": "1", "start_pos": 21577645, "end_pos": 21560680, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000539907.5", "url": "https://www.ensembl.org/id/ENST00000539907.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000437674.1", "url": "https://www.ensembl.org/id/ENSP00000437674.1" } ] } }, { "isoform_ac": "P05186-3", "url": "", "sequence": { "sequence": "MFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF", "length": 469, "header": "sp|P05186-3|PPBT_HUMAN Isoform 3 of Alkaline phosphatase, tissue-nonspecific isozyme OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 CANONICAL=P05186-1" }, "locus": { "chromosome": "1", "start_pos": 21577645, "end_pos": 21560730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000540617.5", "url": "https://www.ensembl.org/id/ENST00000540617.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000442672.1", "url": "https://www.ensembl.org/id/ENSP00000442672.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G48414YA", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 140, "start_aa": "Asn", "end_pos": 140, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn140", "evidence": [ { "id": "1916", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1916" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 140, "start_aa": "Asn", "end_pos": 140, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn140", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 230, "start_aa": "Asn", "end_pos": 230, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn230", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { 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Mutations in brief no. 217. Online.", "journal": "Human mutation", "date": "1999", "authors": "Taillandier A, Zurutuza L, Muller F, Simon-Bouy B, Serre JL, Bird L, Brenner R, Boute O, Cousin J, Gaillard D, Heidemann PH, Steinmann B, Wallot M, Mornet E", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "10094560", "url": "https://glygen.org/publication/PubMed/10094560" } ] }, { "title": "Correlations of genotype and phenotype in hypophosphatasia.", "journal": "Human molecular genetics", "date": "1999", "authors": "Zurutuza L, Muller F, Gibrat JF, Taillandier A, Simon-Bouy B, Serre JL, Mornet E", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "10332035", "url": "https://glygen.org/publication/PubMed/10332035" } ] }, { "title": "Fifteen new mutations (-195C>T, L-12X, 298-2A>G, T117N, A159T, R229S, 997+2T>A, E274X, A331T, H364R, D389G, 1256delC, R433H, N461I, C472S) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in patients with hypophosphatasia.", "journal": "Human mutation", "date": "2000", "authors": "Taillandier A, Cozien E, Muller F, Merrien Y, Bonnin E, Fribourg C, Simon-Bouy B, Serre JL, Bieth E, Brenner R, Cordier MP, De Bie S, Fellmann F, Freisinger P, Hesse V, Hennekam RC, Josifova D, Kerzin-Storrar L, Leporrier N, Zabot MT, Mornet E", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "10679946", "url": "https://glygen.org/publication/PubMed/10679946" } ] }, { "title": "Asp361Val Mutant of alkaline phosphatase found in patients with dominantly inherited hypophosphatasia inhibits the activity of the wild-type enzyme.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2000", "authors": "Muller HL, Yamazaki M, Michigami T, Kageyama T, Schonau E, Schneider P, Ozono K", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "10690885", "url": "https://glygen.org/publication/PubMed/10690885" } ] }, { "title": "Severe hypercalcaemia and respiratory insufficiency associated with infantile hypophosphatasia caused by two novel mutations of the tissue-nonspecific alkaline phosphatase gene.", "journal": "European journal of pediatrics", "date": "2000", "authors": "Mochizuki H, Saito M, Michigami T, Ohashi H, Koda N, Yamaguchi S, Ozono K", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "10834525", "url": "https://glygen.org/publication/PubMed/10834525" } ] }, { "title": "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Schofield JN, Rademacher TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125" } ], "reference": [ { "type": "PubMed", "id": "11072085", "url": "https://glygen.org/publication/PubMed/11072085" } ] }, { "title": "Structural evidence for a functional role of human tissue nonspecific alkaline phosphatase in bone mineralization.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Mornet E, Stura E, Lia-Baldini AS, Stigbrand T, Menez A, Le Du MH", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "11395499", "url": "https://glygen.org/publication/PubMed/11395499" } ] }, { "title": "Twelve novel mutations in the tissue-nonspecific alkaline phosphatase gene (ALPL) in patients with various forms of hypophosphatasia.", "journal": "Human mutation", "date": "2001", "authors": "Taillandier A, Lia-Baldini AS, Mouchard M, Robin B, Muller F, Simon-Bouy B, Serre JL, Bera-Louville A, Bonduelle M, Eckhardt J, Gaillard D, Myhre AG, Kortge-Jung S, Larget-Piet L, Malou E, Sillence D, Temple IK, Viot G, Mornet E", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "11438998", "url": "https://glygen.org/publication/PubMed/11438998" } ] }, { "title": "A molecular approach to dominance in hypophosphatasia.", "journal": "Human genetics", "date": "2001", "authors": "Lia-Baldini AS, Muller F, Taillandier A, Gibrat JF, Mouchard M, Robin B, Simon-Bouy B, Serre JL, Aylsworth AS, Bieth E, Delanote S, Freisinger P, Hu JC, Krohn HP, Nunes ME, Mornet E", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "11479741", "url": "https://glygen.org/publication/PubMed/11479741" } ] }, { "title": "Perinatal hypophosphatasia: radiology, pathology and molecular biology studies in a family harboring a splicing mutation (648+1A) and a novel missense mutation (N400S) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene.", "journal": "American journal of medical genetics", "date": "2001", "authors": "Sergi C, Mornet E, Troeger J, Voigtlaender T", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": 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Ishikawa I", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "11834095", "url": "https://glygen.org/publication/PubMed/11834095" } ] }, { "title": "Denaturing gradient gel electrophoresis analysis of the tissue nonspecific alkaline phosphatase isoenzyme gene in hypophosphatasia.", "journal": "Molecular genetics and metabolism", "date": "2002", "authors": "Mumm S, Jones J, Finnegan P, Henthorn PS, Podgornik MN, Whyte MP", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "11855933", "url": "https://glygen.org/publication/PubMed/11855933" } ] }, { "title": "Glu274Lys/Gly309Arg mutation of the tissue-nonspecific alkaline phosphatase gene in neonatal hypophosphatasia associated with convulsions.", "journal": "Journal of inherited metabolic disease", "date": "2002", "authors": "Litmanovitz, 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"url": "https://glygen.org/publication/PubMed/12920074" } ] }, { "title": "Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1992", "authors": "Henthorn PS, Raducha M, Fedde KN, Lafferty MA, Whyte MP", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "1409720", "url": "https://glygen.org/publication/PubMed/1409720" } ] }, { "title": "Chemical nature of intestinal-type alkaline phosphatase in human kidney.", "journal": "Clinical chemistry", "date": "1992", "authors": "Nishihara Y, Hayashi Y, Adachi T, Koyama I, Stigbrand T, Hirano K", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": 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"id": "15694177", "url": "https://glygen.org/publication/PubMed/15694177" } ] }, { "title": "Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.", "journal": "Proteomics", "date": "2007", "authors": "Omaetxebarria Miren J, Elortza Felix, Rodr\u00edguez-Su\u00e1rez Eva, Aloria Kerman, Arizmendi Jesus M, Jensen Ole N, Matthiesen Rune", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "17566972", "url": "https://glygen.org/publication/PubMed/17566972" } ] }, { "title": "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.", "journal": "Journal of proteome research", "date": "2009", "authors": "Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": 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tissue-nonspecific alkaline phosphatase (TNSALP) gene in European patients with severe hypophosphatasia.", "journal": "European journal of human genetics : EJHG", "date": "1998", "authors": "Mornet E, Taillandier A, Peyramaure S, Kaper F, Muller F, Brenner R, Bussiere P, Freisinger P, Godard J, Le Merrer M, Oury JF, Plauchu H, Puddu R, Rival JM, Superti-Furga A, Touraine RL, Serre JL, Simon-Bouy B", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "reference": [ { "type": "PubMed", "id": "9781036", "url": "https://glygen.org/publication/PubMed/9781036" } ] } ], "pathway": [ { "id": "hsa:249", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:249", "resource": "KEGG Pathway" }, { "id": "R-HSA-163125", "name": "Post-translational modification: synthesis of GPI-anchored proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125", "resource": "Reactome", "description": "Post-translational 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"https://www.ebi.ac.uk/QuickGO/term/GO:0004427", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "phosphoamidase activity", "id": "GO:0050187", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050187", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "side of membrane", "id": "GO:0098552", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 23, "go_terms": [ { "name": "developmental process involved in reproduction", "id": "GO:0003006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003006", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "dephosphorylation", "id": "GO:0016311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016311", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to sodium phosphate", "id": "GO:1904383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904383", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "cellular homeostasis", "id": "GO:0019725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019725", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to glucocorticoid", "id": "GO:0051384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051384", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "skeletal system development", "id": "GO:0001501", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to insulin", "id": "GO:0032868", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to antibiotic", "id": "GO:0046677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046677", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "osteoblast differentiation", "id": "GO:0001649", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001649", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "cellular response to organic cyclic compound", "id": "GO:0071407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071407", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "phosphate ion homeostasis", "id": "GO:0055062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055062", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "calcium ion homeostasis", "id": "GO:0055074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055074", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to vitamin D", "id": "GO:0033280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033280", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "bone mineralization", "id": "GO:0030282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030282", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "cementum mineralization", "id": "GO:0071529", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071529", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to vitamin B6", "id": "GO:0034516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034516", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "endochondral ossification", "id": "GO:0001958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001958", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "positive regulation of cold-induced thermogenesis", "id": "GO:0120162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120162", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "inhibition of non-skeletal tissue mineralization", "id": "GO:0140928", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140928", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "pyridoxal phosphate metabolic process", "id": "GO:0042822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042822", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "futile creatine cycle", "id": "GO:0140651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140651", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" }, { "name": "response to macrophage colony-stimulating factor", "id": "GO:0036005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036005", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 140, "end_pos": 142, "annotation": "n_glycosylation_sequon" }, { "start_pos": 230, "end_pos": 232, "annotation": "n_glycosylation_sequon" }, { "start_pos": 271, "end_pos": 273, "annotation": "n_glycosylation_sequon" }, { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 430, "end_pos": 432, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "P05186", "url": "https://www.uniprot.org/uniprot/P05186" }, { "database": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" }, { "database": "PubMed", "id": "1458595", "url": "https://glygen.org/publication/PubMed/1458595" } ] } ], "interactions": [], "reactions": [ { "id": "12977", "name": "", "equation": "H2O + N-phosphocreatine = creatine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08289-1", "P05186-1", "P09242-1" ], "evidence": [ { "id": "12977", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/12977" } ] }, { "id": "13065", "name": "", "equation": "ATP + H2O = ADP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZD32-1", "A0A8I5ZKX7-1", "D4A7Q5-1", "D4A523-1", "Q3MHU3-1", "Q6AYJ1-1", "F1M298-1", "Q5RJZ1-1", "P60123-1", "Q793F9-1", "F1LPQ2-1", "G3V681-1", "D4ACP5-1", "F1LNJ2-1", "D4A2Z8-1", "Q6P3V8-1", "Q5RKI1-1", "A0A0G2K0E0-1", "G3V9M1-1", "P70486-1", "Q66HG7-1", "Q99PT0-1", "D3ZG52-1", "Q4G005-1", "Q5BJS0-1", "Q64060-1", "Q9JIX5-1", "P06761-1", "Q5U216-1", "Q62780-1", "Q641Y8-1", "Q5XI69-1", "Q63413-1", "Q1HG60-1", "D3ZA12-1", "D3Z9Z9-1", "Q68G38-1", "Q6GX84-1", "Q9QUL6-1", 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"Q9WTM5-1", "Q01853-1", "Q75NR7-1", "Q8VID5-1", "Q80YD1-1", "Q9Z129-1", "Q0VGM9-1", "Q14BI7-1", "Q3UMC0-1", "Q6P5D8-1", "Q6P4T2-1", "Q9CZU3-1", "Q9ER41-1", "P46467-1", "Q8VEJ9-1", "O09053-1", "B2RR83-1", "F8VPZ5-1", "P63017-1", "P07901-1", "P09242-1", "Q3TCT4-1", "D3Z0M9-1", "Q69ZX6-1", "Q9D2Q3-1", "P70270-1", "Q91XU0-1", "A2ACQ1-1", "Q80X98-1", "B1AR17-1", "G3X8X0-1", "Q8CDM1-1", "Q60649-1", "Q8C5W4-1", "Q9CXF7-1", "Q99LC9-1", "Q8R4B8-1", "Q8K2I9-1", "Q9CQA9-1", "P60710-1", "P63268-1", "P63260-1", "P62737-1", "P68134-1", "P54279-1", "P28738-1", "E9Q555-1", "P68033-1", "Q5BL07-1", "Q9EPU0-1", "A0A7N9VSG0-1", "Q6NZR5-1", "Q8CIW5-1", "Q6NZL1-1", "P55772-1", "Q8CGS6-1", "Q0VGT4-1", "P61222-1", "E9QAM5-1", "P15424-1", "P15938-1", "P16474-1", "P16521-1", "P20095-1", "P20447-1", "P20448-1", "P20449-1", "P21372-1", "P22516-1", "P23394-1", "P24004-1", "P24279-1", "P24384-1", "P24783-1", "P25808-1", "P29496-1", "P32863-1", "P33760-1", "P35187-1", "P35207-1", "P38132-1", "P38859-1", "P39517-1", "Q03532-1", "Q03940-1", "Q12464-1", "P06634-1", "P06839-1", "P07271-1", "P0CS90-1", "P10081-1", "P11484-1", "P12954-1", "P24784-1", "P25694-1", "P29469-1", "P32597-1", "P32644-1", "P53131-1", "P60010-1", "Q04437-1", "Q05931-1", "Q06218-1", "P30665-1", "P30771-1", "P31380-1", "P32580-1", "P32639-1", "P32794-1", "P32807-1", "P32892-1", "P0CX15-1", "P0CX21-1", "P34243-1", "O13559-1", "P0CX14-1", "P0CX20-1", "P36120-1", "P53978-1", "Q00578-1", "P38712-1", "P38766-1", "P40024-1", "P40150-1", "P40562-1", "P45818-1", "P51979-1", "P53115-1", "P53166-1", "P53327-1", "Q04217-1", "P36009-1", "Q05471-1", "P36016-1", "P38112-1", "P38719-1", "P40352-1", "P47047-1", "P53091-1", "P53734-1", "Q12389-1", "P38086-1", "Q05549-1", "Q07478-1", "Q12039-1", "Q12099-1", "Q12697-1", "P43538-1", "P0CX22-1", "P40105-1", "P40434-1", "P40889-1", "P53819-1", "Q03099-1", "Q06698-1", "Q07888-1", "Q99208-1", "Q08995-1", "Q3E7X8-1", "P17119-1", "P90529-1", "Q869Z1-1", "Q54KG8-1", "Q55F84-1", "Q54DN9-1", "Q54HE9-1", "Q54HF0-1", "Q54HF1-1", "Q54L54-1", "Q54LI7-1", "Q54NW5-1", "Q54P22-1", "Q54XQ3-1", "Q55CU2-1", "Q54VI9-1", "Q553B1-1", "Q54EC2-1", "Q54F05-1", "Q54G57-1", "Q54GX5-1", "Q54HE7-1", "Q54IV3-1", "Q54KG1-1", "Q54NJ4-1", "Q54Q94-1", "Q54QS3-1", "Q54RU0-1", "Q54S03-1", "Q54TD7-1", "Q54TJ4-1", "Q54VF1-1", "Q54VT4-1", "Q54Y81-1", "Q54ZI9-1", "Q554S6-1", "Q55A06-1", "Q55BR9-1", "Q55D61-1", "Q55EU6-1", "Q55F23-1", "Q55FJ4-1", "Q55GK2-1", "Q75JU2-1", "Q869P0-1", "Q86IF1-1", "Q86IZ9-1", "Q75JA0-1", "P07828-1", "Q54CD8-1", "B0G0Y4-1", "O00835-1", "P07829-1", "P07830-1", "Q54BD6-1", "Q54C21-1", "Q54C28-1", "Q54CD6-1", "Q54CE0-1", "Q54CP4-1", "Q54CS8-1", "Q54DG0-1", "Q54DM3-1", "Q54E49-1", "Q54GX7-1", "Q54I89-1", "Q54MA9-1", "Q54MH3-1", "Q54PT2-1", "Q54TF8-1", "Q54UW5-1", "Q54X63-1", "Q54Z42-1", "Q553U6-1", "Q55CP6-1", "Q55G81-1", "Q75JI3-1", "Q86B14-1", "O46072-1", "P23128-1", "P25439-1", "P26802-1", "Q02748-1", "Q26454-1", "Q6J5K9-1", "Q9GQN5-1", "Q9VD51-1", "Q9VL72-1", "Q9VNP5-1", "Q7KN62-1", "Q9V3K3-1", "Q9VF26-1", "Q9VH07-1", "Q9VL52-1", "P49735-1", "Q9V461-1", "Q9VGW6-1", "Q9VDY1-1", "Q7K3M5-1", "P09052-1", "Q9VN03-1", "Q9W484-1", "Q9VGI8-1", "Q9VHS8-1", "Q9VUV9-1", "Q9VYS3-1", "Q9VSE2-1", "Q9VIF6-1", "Q9VVK8-1", "Q9V3C4-1", "O61305-1", "Q9VX34-1", "Q9VRI0-1", "Q9VJ74-1", "Q6NQY9-1", "Q9W3Y5-1", "Q7KU24-1", "Q02870-1", "Q07886-1", "Q23976-1", "Q27268-1", "Q9V3C0-1", "Q9VHP0-1", "Q9VHU1-1", "Q9VNV3-1", "Q9VQN8-1", "P24785-1", "P46461-1", "P54351-1", "Q86B47-1", "A8DZ26-1", "P19109-1", "P29844-1", "Q9V433-1", "Q7KVP9-1", "A1Z9L3-1", "O16102-1", "O97159-1", "Q9XYU0-1", "Q9XYU1-1", "Q9I7M8-1", "Q9VL25-1", "Q9VY54-1", "Q8SWT2-1", "Q8IRL9-1", "Q8ING5-1", "Q8SY39-1", "Q9VPT3-1", "P10987-1", "P10981-1", "P20480-1", "Q9VQR3-1", "P53501-1", "P02572-1", "P83967-1", "P02574-1", "Q9VIZ3-1", "Q9VL76-1", "Q9VDA0-1", "Q9W4W2-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "15017", "name": "", "equation": "a phosphate monoester + H2O = an alcohol + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P20611-1", "P51740-1", "P08289-1", "P15693-1", "P29288-1", "P20646-1", "P41498-1", "F1M8U7-1", "A0A0G2JZL2-1", "D4ADM6-1", "M0RCA8-1", "A0A8I6G7Q4-1", "Q6ZNF0-1", "Q9BZG2-1", "P13686-1", "P11117-1", "P05186-1", "P15309-1", "P09923-1", "Q9NPH0-1", "P05187-1", "P10696-1", "P24666-1", "Q8BX37-1", "D3YTS9-1", "Q8BP40-1", "Q9D358-1", "Q05117-1", "P24638-1", "P24822-1", "P24823-1", "Q8CE08-1", "P09242-1", "F8VPQ6-1", "P00635-1", "P11491-1", "P35842-1", "P40347-1", "P24031-1", "P38693-1", "P52290-1", "Q54NC3-1", "Q54P71-1", "Q54P72-1", "Q54SB4-1", "Q54TC4-1", "Q558S4-1", "Q54BS2-1", "Q54Y02-1", "Q55GW2-1", "Q55F77-1", "Q55F12-1", "P82890-1", "P82891-1", "Q24238-1", "X2JB52-1", "Q9W273-1", "Q9W274-1", "Q9VDG4-1", "Q7K3X8-1", "Q9VHD0-1", "Q9W275-1", "B7Z080-1", "Q8I0P9-1", "Q9VW00-1", "Q9VQ86-1" ], "evidence": [ { "id": "15017", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15017" } ] }, { "id": "16089", "name": "", "equation": "H2O + phosphoethanolamine = ethanolamine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08289-1", "Q8TCT1-1", "P05186-1", "Q8R2H9-1", "P09242-1" ], "evidence": [ { "id": "16089", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16089" } ] }, { "id": "20533", "name": "", "equation": "H2O + pyridoxal 5'-phosphate = phosphate + pyridoxal", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VD52-1", "Q66HC4-1", "P08289-1", "Q8TCD6-1", "Q96GD0-1", "P05186-1", "P60487-1", "Q9D9M5-1", "P09242-1" ], "evidence": [ { "id": "20533", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20533" } ] }, { "id": "24576", "name": "", "equation": "diphosphate + H2O = H(+) + 2 phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5I0D5-1", "Q6AYG3-1", "P08289-1", "F7EPH4-1", "Q15181-1", "Q9H2U2-1", "Q9H008-1", "Q86TP1-1", "P05186-1", "Q9D7I5-1", "Q9D819-1", "Q91VM9-1", "Q8BIW1-1", "P09242-1", "P00817-1", "P28239-1", "Q54PV8-1", "O77460-1" ], "evidence": [ { "id": "24576", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24576" } ] }, { "id": "29375", "name": "", "equation": "AMP + H2O = adenosine + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08289-1", "P21588-1", "P05186-1", "Q9BXI3-1", "P21589-1", "Q96P26-1", "P09242-1", "Q91YE9-1", "Q61503-1", "A3KFX0-1" ], "evidence": [ { "id": "29375", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29375" } ] }, { "id": "61436", "name": "", "equation": "ADP + H2O = AMP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P08289-1", "Q6P6S9-1", "P97687-1", "P05186-1", "O75356-1", "P49961-1", "P09242-1", "Q9WUZ9-1", "P55772-1" ], "evidence": [ { "id": "61436", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/61436" } ] }, { "id": "R-HSA-8940388", "name": "GPLD1 hydrolyses GPI-anchors from proteins", "equation": "", "summary": "Some proteins function at the cell's surface, attached to the plasma membrane via GPI (glycosylphosphatidylinositol) anchors and include enzymes, receptors, cell adhesion molecules and antigens. These GPI-anchored proteins participate in many important cellular functions including immune recognition, complement regulation and intracellular signaling. Phosphatidylinositol-glycan-specific phospholipase D (GPLD1) (Schofield et al. 2000) is a secreted protein that specifically cleaves GPI-anchored proteins by cleaving the linkage between the phosphate and inositol in GPI (Davitz et al. 1987, Low & Prasad 1988). In addition, it also localises to the ER where it can cleave GPI anchor intermediates transiting to the plasma membrane (not shown here). GPLD1 may play a role in the regulation of GPI-anchored proteins on (intra)cellular membranes.", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2197633" ], "enzyme_list": [ "Q7RTY9-1", "Q9Y6M0-1", "O43895-1", "Q13508-1", "P80108-1", "P10696-1", "Q93070-1", "O95497-1", "O95498-1", "Q10588-1", "P14384-1", "P09923-1", "P05186-1" ], "evidence": [ { "id": "R-HSA-8940388", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8940388" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2197633", "participant_name": "PI [extracellular region]", "crossref": [ { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJV7", "gene_name": "Chd9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] } ] }, { "uniprot_ac": "A0A0G2JTM6", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] } ] }, { "uniprot_ac": "A0A0G2JZL2", "gene_name": "Akp3", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate 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"A8DZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8DZ26" } ] } ] }, { "uniprot_ac": "A8MPP1", "gene_name": "DDX11L8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A8MPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8MPP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A8MPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8MPP1" } ] } ] }, { "uniprot_ac": "B0G0Y4", "gene_name": "wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B0G0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B0G0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y4" } ] } ] }, { "uniprot_ac": "B1AR17", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B1AR17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AR17" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B1AR17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AR17" } ] } ] }, { "uniprot_ac": "B2GUX3", "gene_name": "Mcm5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] } ] }, { "uniprot_ac": "B2RR83", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2RR83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RR83" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "B2RR83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RR83" } ] } ] }, { "uniprot_ac": "B7Z080", "gene_name": "Dmel\\CG9449", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "B7Z080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7Z080" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "B7Z080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7Z080" } ] } ] }, { "uniprot_ac": "D3YTS9", "gene_name": "Acp4", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "D3YTS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YTS9" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "D3YTS9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YTS9" } ] } ] }, { "uniprot_ac": "D3Z0M9", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z0M9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3Z0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z0M9" } ] } ] }, { "uniprot_ac": "D3Z4R1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z4R1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z4R1" } ] } ] }, { "uniprot_ac": "D3Z9Z9", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] } ] }, { "uniprot_ac": "D3ZA12", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] } ] }, { "uniprot_ac": "D3ZAP7", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] } ] }, { "uniprot_ac": "D3ZBY5", "gene_name": "Ddx10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] } ] }, { "uniprot_ac": "D3ZD32", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] } ] }, { "uniprot_ac": "D3ZD46", "gene_name": "Dhx58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] } ] }, { "uniprot_ac": "D3ZD97", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFP4", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] } ] }, { "uniprot_ac": "D3ZG52", "gene_name": "Dna2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] } ] }, { "uniprot_ac": "D3ZH42", "gene_name": "Mov10l1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZH42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZH42" } ] } ] }, { "uniprot_ac": "D3ZHW0", "gene_name": "Dhx29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] } ] }, { "uniprot_ac": "D3ZP96", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] } ] }, { "uniprot_ac": "D3ZQW1", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] } ] }, { "uniprot_ac": "D3ZSV6", "gene_name": "Dhx33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] } ] }, { "uniprot_ac": "D3ZUC2", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] } ] }, { "uniprot_ac": "D4A1R0", "gene_name": "Dhx37", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A523" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4A7Q5", "gene_name": "Ddx28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7Q5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7Q5" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADM6", "gene_name": "Alpp", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "D4ADM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADM6" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "D4ADM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADM6" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] } ] }, { "uniprot_ac": "E9PZJ8", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PZJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZJ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PZJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZJ8" } ] } ] }, { "uniprot_ac": "E9PZM4", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PZM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZM4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PZM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZM4" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9QAM5", "gene_name": "Helz2", "activity": [ { "ec_number": "3.1.13.1", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] }, { "ec_number": "3.1.13.1", "activity": "", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTH9", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] } ] }, { "uniprot_ac": "F1M298", "gene_name": "Fbh1", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] } ] }, { "uniprot_ac": "F1M5F3", "gene_name": "Mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] } ] }, { "uniprot_ac": "F1M8U7", "gene_name": "Alpg", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F1M8U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8U7" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F1M8U7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8U7" } ] } ] }, { "uniprot_ac": "F1M9L4", "gene_name": "Atp13a4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1M9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9L4" } ] } ] }, { "uniprot_ac": "F1MA70", "gene_name": "Atp13a5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1MA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MA70" } ] } ] }, { "uniprot_ac": "F7EPH4", "gene_name": "Ppa1", "activity": [ { "ec_number": "3.6.1.1", "activity": "diphosphate + H2O = H(+) + 2 phosphate.", "evidence": [ { "id": "F7EPH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EPH4" } ] }, { "ec_number": "3.6.1.1", "activity": "", "evidence": [ { "id": "F7EPH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EPH4" } ] } ] }, { "uniprot_ac": "F8VPQ6", "gene_name": "Alpi", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "F8VPQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPQ6" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "F8VPQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPQ6" } ] } ] }, { "uniprot_ac": "F8VPZ5", "gene_name": "Ercc6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F8VPZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPZ5" } ] } ] }, { "uniprot_ac": "G3V681", "gene_name": "Mcm4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] } ] }, { "uniprot_ac": "G3V6W5", "gene_name": "Ifih1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] } ] }, { "uniprot_ac": "G3V8T5", "gene_name": "Ruvbl2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] } ] }, { "uniprot_ac": "G3V9M1", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9M1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9M1" } ] } ] }, { "uniprot_ac": "G3X8X0", "gene_name": "Dhx16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3X8X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3X8X0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3X8X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3X8X0" } ] } ] }, { "uniprot_ac": "M0RCA8", "gene_name": "Acp7", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "M0RCA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCA8" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "M0RCA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCA8" } ] } ] }, { "uniprot_ac": "O00148", "gene_name": "DDX39A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00148" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O00148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00148" } ] } ] }, { "uniprot_ac": "O00571", "gene_name": "DDX3X", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00571" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O00571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00571" } ] } ] }, { "uniprot_ac": "O00835", "gene_name": "repB", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] } ] }, { "uniprot_ac": "O08811", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O08811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08811" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O08811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08811" } ] } ] }, { "uniprot_ac": "O09053", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] } ] }, { "uniprot_ac": "O13559", "gene_name": "YRF1-4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O13559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13559" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O13559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13559" } ] } ] }, { "uniprot_ac": "O14646", "gene_name": "CHD1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14646" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14646" } ] } ] }, { "uniprot_ac": "O14647", "gene_name": "CHD2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O14647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14647" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O14647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14647" } ] } ] }, { "uniprot_ac": "O14656", "gene_name": "TOR1A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O14656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14656" } ] } ] }, { "uniprot_ac": "O14657", "gene_name": "TOR1B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O14657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14657" } ] } ] }, { "uniprot_ac": "O15523", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O15523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15523" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O15523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15523" } ] } ] }, { "uniprot_ac": "O16102", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O16102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O16102" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O16102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O16102" } ] } ] }, { "uniprot_ac": "O35286", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O35286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35286" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O35286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35286" } ] } ] }, { "uniprot_ac": "O43143", "gene_name": "DHX15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] } ] }, { "uniprot_ac": "O43895", "gene_name": "XPNPEP2", "activity": [ { "ec_number": "3.4.11.9", "activity": "Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.", "evidence": [ { "id": "O43895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43895" } ] }, { "ec_number": "3.4.11.9", "activity": "", "evidence": [ { "id": "O43895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43895" } ] } ] }, { "uniprot_ac": "O43933", "gene_name": "PEX1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O43933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43933" } ] } ] }, { "uniprot_ac": "O46072", "gene_name": "kz", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O46072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46072" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O46072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46072" } ] } ] }, { "uniprot_ac": "O60231", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] } ] }, { "uniprot_ac": "O60282", "gene_name": "KIF5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O60282", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60282" } ] } ] }, { "uniprot_ac": "O60306", "gene_name": "AQR", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] } ] }, { "uniprot_ac": "O61305", "gene_name": "Dbp80", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O61305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61305" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O61305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61305" } ] } ] }, { "uniprot_ac": "O70133", "gene_name": "Dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O70133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70133" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O70133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70133" } ] } ] }, { "uniprot_ac": "O75351", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75351" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "O75351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75351" } ] } ] }, { "uniprot_ac": "O75356", "gene_name": "ENTPD5", "activity": [ { "ec_number": "3.6.1.6", "activity": "ADP + H2O = AMP + H(+) + phosphate.", "evidence": [ { "id": "O75356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75356" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "O75356", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75356" } ] } ] }, { "uniprot_ac": "O75417", "gene_name": "POLQ", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] } ] }, { "uniprot_ac": "O75643", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] } ] }, { "uniprot_ac": "O77460", "gene_name": "Nurf-38", "activity": [ { "ec_number": "3.6.1.1", "activity": "diphosphate + H2O = H(+) + 2 phosphate.", "evidence": [ { "id": "O77460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O77460" } ] }, { "ec_number": "3.6.1.1", "activity": "", "evidence": [ { "id": "O77460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O77460" } ] } ] }, { "uniprot_ac": "O88700", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] } ] }, { "uniprot_ac": "O94761", "gene_name": "RECQL4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O94761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94761" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O94761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94761" } ] } ] }, { "uniprot_ac": "O94762", "gene_name": "RECQL5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O94762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94762" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O94762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94762" } ] } ] }, { "uniprot_ac": "O95497", "gene_name": "VNN1", "activity": [ { "ec_number": "3.5.1.92", "activity": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine.", "evidence": [ { "id": "O95497", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95497" } ] }, { "ec_number": "3.5.1.92", "activity": "", "evidence": [ { "id": "O95497", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95497" } ] } ] }, { "uniprot_ac": "O95498", "gene_name": "VNN2", "activity": [ { "ec_number": "3.5.1.92", "activity": "(R)-pantetheine + H2O = (R)-pantothenate + cysteamine.", "evidence": [ { "id": "O95498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95498" } ] }, { "ec_number": "3.5.1.92", "activity": "", "evidence": [ { "id": "O95498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95498" } ] } ] }, { "uniprot_ac": "O95786", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O95786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95786" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O95786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95786" } ] } ] }, { "uniprot_ac": "O97159", "gene_name": "Mi-2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O97159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97159" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O97159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97159" } ] } ] }, { "uniprot_ac": "P00635", "gene_name": "PHO5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P00635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00635" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P00635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00635" } ] } ] }, { "uniprot_ac": "P00817", "gene_name": "IPP1", "activity": [ { "ec_number": "3.6.1.1", "activity": "diphosphate + H2O = H(+) + 2 phosphate.", "evidence": [ { "id": "P00817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00817" } ] }, { "ec_number": "3.6.1.1", "activity": "", "evidence": [ { "id": "P00817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00817" } ] } ] }, { "uniprot_ac": "P02572", "gene_name": "Act42A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02572" } ] } ] }, { "uniprot_ac": "P02574", "gene_name": "Act79B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02574" } ] } ] }, { "uniprot_ac": "P05186", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] } ] }, { "uniprot_ac": "P05187", "gene_name": "ALPP", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P05187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05187" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P05187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05187" } ] } ] }, { "uniprot_ac": "P06634", "gene_name": "DED1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06634" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P06634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06634" } ] } ] }, { "uniprot_ac": "P06761", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] } ] }, { "uniprot_ac": "P06839", "gene_name": "RAD3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06839" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P06839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06839" } ] } ] }, { "uniprot_ac": "P07271", "gene_name": "PIF1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07271" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P07271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07271" } ] } ] }, { "uniprot_ac": "P07828", "gene_name": "act18", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07828" } ] } ] }, { "uniprot_ac": "P07829", "gene_name": "act3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07829" } ] } ] }, { "uniprot_ac": "P07830", "gene_name": "act19", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07830" } ] } ] }, { "uniprot_ac": "P07900", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] } ] }, { "uniprot_ac": "P07901", "gene_name": "Hsp90aa1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07901" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07901" } ] } ] }, { "uniprot_ac": "P08289", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] } ] }, { "uniprot_ac": "P09052", "gene_name": "vas", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P09052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09052" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P09052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09052" } ] } ] }, { "uniprot_ac": "P09242", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] } ] }, { "uniprot_ac": "P09923", "gene_name": "ALPI", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09923" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09923" } ] } ] }, { "uniprot_ac": "P0CS90", "gene_name": "SSC1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CS90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CS90" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P0CS90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CS90" } ] } ] }, { "uniprot_ac": "P0CX14", "gene_name": "YRF1-3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX14" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX14" } ] } ] }, { "uniprot_ac": "P0CX15", "gene_name": "YRF1-7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX15" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX15" } ] } ] }, { "uniprot_ac": "P0CX20", "gene_name": "YRF1-1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX20" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX20" } ] } ] }, { "uniprot_ac": "P0CX21", "gene_name": "YRF1-5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX21" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX21" } ] } ] }, { "uniprot_ac": "P0CX22", "gene_name": "YRF1-8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX22" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX22" } ] } ] }, { "uniprot_ac": "P10081", "gene_name": "TIF1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P10081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10081" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P10081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10081" } ] } ] }, { "uniprot_ac": "P10630", "gene_name": "Eif4a2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P10630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10630" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P10630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10630" } ] } ] }, { "uniprot_ac": "P10696", "gene_name": "ALPG", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P10696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10696" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P10696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10696" } ] } ] }, { "uniprot_ac": "P10981", "gene_name": "Act87E", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10981" } ] } ] }, { "uniprot_ac": "P10987", "gene_name": "Act5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10987" } ] } ] }, { "uniprot_ac": "P11021", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11021" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11021" } ] } ] }, { "uniprot_ac": "P11117", "gene_name": "ACP2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11117" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P11117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11117" } ] } ] }, { "uniprot_ac": "P11142", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] } ] }, { "uniprot_ac": "P11484", "gene_name": "SSB1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11484" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11484" } ] } ] }, { "uniprot_ac": "P11491", "gene_name": "PHO8", "activity": [ { "ec_number": "3.1.7.6", "activity": "(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate.", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] }, { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] }, { "ec_number": "3.1.3.54", "activity": "beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 2-phosphate + phosphate.", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P11491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11491" } ] } ] }, { "uniprot_ac": "P12954", "gene_name": "SRS2", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "P12954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12954" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "P12954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12954" } ] } ] }, { "uniprot_ac": "P13686", "gene_name": "ACP5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13686" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P13686", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13686" } ] } ] }, { "uniprot_ac": "P14384", "gene_name": "CPM", "activity": [ { "ec_number": "3.4.17.12", "activity": "Cleavage of C-terminal arginine or lysine residues from polypeptides.", "evidence": [ { "id": "P14384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14384" } ] }, { "ec_number": "3.4.17.12", "activity": "", "evidence": [ { "id": "P14384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14384" } ] } ] }, { "uniprot_ac": "P15309", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] } ] }, { "uniprot_ac": "P15424", "gene_name": "MSS116", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P15424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15424" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P15424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15424" } ] } ] }, { "uniprot_ac": "P15693", "gene_name": "Alpi", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15693" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P15693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15693" } ] } ] }, { "uniprot_ac": "P15938", "gene_name": "PRP16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P15938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15938" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P15938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15938" } ] } ] }, { "uniprot_ac": "P16381", "gene_name": "D1Pas1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P16381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16381" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P16381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16381" } ] } ] }, { "uniprot_ac": "P16474", "gene_name": "KAR2", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P16474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16474" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P16474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16474" } ] } ] }, { "uniprot_ac": "P16521", "gene_name": "YEF3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P16521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16521" } ] } ] }, { "uniprot_ac": "P17119", "gene_name": "KAR3", "activity": [ { "ec_number": "5.6.1.4", "activity": "ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate + a kinesin associated with a microtubule at position (n-1, toward the minus end).", "evidence": [ { "id": "P17119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17119" } ] }, { "ec_number": "5.6.1.4", "activity": "", "evidence": [ { "id": "P17119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17119" } ] } ] }, { "uniprot_ac": "P17844", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] } ] }, { "uniprot_ac": "P18074", "gene_name": "ERCC2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P18074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18074" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P18074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18074" } ] } ] }, { "uniprot_ac": "P19109", "gene_name": "Rm62", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P19109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19109" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P19109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19109" } ] } ] }, { "uniprot_ac": "P19447", "gene_name": "ERCC3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P19447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19447" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P19447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19447" } ] } ] }, { "uniprot_ac": "P20029", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20029" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P20029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20029" } ] } ] }, { "uniprot_ac": "P20095", "gene_name": "PRP2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20095" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20095" } ] } ] }, { "uniprot_ac": "P20447", "gene_name": "DBP3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20447" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20447" } ] } ] }, { "uniprot_ac": "P20448", "gene_name": "HCA4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20448" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20448" } ] } ] }, { "uniprot_ac": "P20449", "gene_name": "DBP5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20449" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20449" } ] } ] }, { "uniprot_ac": "P20480", "gene_name": "ncd", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P20480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20480" } ] } ] }, { "uniprot_ac": "P20611", "gene_name": "Acp2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20611", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20611" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20611", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20611" } ] } ] }, { "uniprot_ac": "P20646", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] } ] }, { "uniprot_ac": "P21372", "gene_name": "PRP5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P21372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21372" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P21372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21372" } ] } ] }, { "uniprot_ac": "P21588", "gene_name": "Nt5e", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.91", "activity": "CMP + H2O = cytidine + phosphate.", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.89", "activity": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.99", "activity": "H2O + IMP = inosine + phosphate.", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.35", "activity": "dTMP + H2O = phosphate + thymidine.", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.89", "activity": "", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.35", "activity": "", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.99", "activity": "", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] }, { "ec_number": "3.1.3.91", "activity": "", "evidence": [ { "id": "P21588", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21588" } ] } ] }, { "uniprot_ac": "P21589", "gene_name": "NT5E", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.5", "activity": "", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.91", "activity": "CMP + H2O = cytidine + phosphate.", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.89", "activity": "a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.99", "activity": "H2O + IMP = inosine + phosphate.", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.35", "activity": "dTMP + H2O = phosphate + thymidine.", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.91", "activity": "", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.99", "activity": "", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.35", "activity": "", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] }, { "ec_number": "3.1.3.89", "activity": "", "evidence": [ { "id": "P21589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21589" } ] } ] }, { "uniprot_ac": "P22516", "gene_name": "CHL1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P22516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22516" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P22516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22516" } ] } ] }, { "uniprot_ac": "P23128", "gene_name": "me31B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23128" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23128" } ] } ] }, { "uniprot_ac": "P23249", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23249" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23249" } ] } ] }, { "uniprot_ac": "P23394", "gene_name": "PRP28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23394" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23394" } ] } ] }, { "uniprot_ac": "P24004", "gene_name": "PEX1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P24004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24004" } ] } ] }, { "uniprot_ac": "P24031", "gene_name": "PHO3", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24031" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P24031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24031" } ] } ] }, { "uniprot_ac": "P24279", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24279" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P24279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24279" } ] } ] }, { "uniprot_ac": "P24384", "gene_name": "PRP22", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24384" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24384" } ] } ] }, { "uniprot_ac": "P24638", "gene_name": "Acp2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24638" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P24638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24638" } ] } ] }, { "uniprot_ac": "P24666", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] } ] }, { "uniprot_ac": "P24783", "gene_name": "DBP2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24783" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24783" } ] } ] }, { "uniprot_ac": "P24784", "gene_name": "DBP1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24784" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24784" } ] } ] }, { "uniprot_ac": "P24785", "gene_name": "mle", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24785" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24785" } ] } ] }, { "uniprot_ac": "P24822", "gene_name": "Iap", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24822" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P24822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24822" } ] } ] }, { "uniprot_ac": "P24823", "gene_name": "Alpg", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24823" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P24823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24823" } ] } ] }, { "uniprot_ac": "P25205", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25205" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25205" } ] } ] }, { "uniprot_ac": "P25206", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25206" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25206" } ] } ] }, { "uniprot_ac": "P25439", "gene_name": "brm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25439" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25439", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25439" } ] } ] }, { "uniprot_ac": "P25694", "gene_name": "CDC48", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25694" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P25694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25694" } ] } ] }, { "uniprot_ac": "P25808", "gene_name": "SPB4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25808" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P25808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25808" } ] } ] }, { "uniprot_ac": "P26196", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P26196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26196" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P26196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26196" } ] } ] }, { "uniprot_ac": "P26802", "gene_name": "Dbp73D", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P26802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26802" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P26802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26802" } ] } ] }, { "uniprot_ac": "P28239", "gene_name": "PPA2", "activity": [ { "ec_number": "3.6.1.1", "activity": "diphosphate + H2O = H(+) + 2 phosphate.", "evidence": [ { "id": "P28239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28239" } ] }, { "ec_number": "3.6.1.1", "activity": "", "evidence": [ { "id": "P28239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28239" } ] } ] }, { "uniprot_ac": "P28738", "gene_name": "Kif5c", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P28738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28738" } ] } ] }, { "uniprot_ac": "P29288", "gene_name": "Acp5", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P29288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29288" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P29288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29288" } ] } ] }, { "uniprot_ac": "P29469", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29469" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P29469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29469" } ] } ] }, { "uniprot_ac": "P29496", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29496" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P29496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29496" } ] } ] }, { "uniprot_ac": "P29844", "gene_name": "Hsc70-3", "activity": [ { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "P29844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29844" } ] }, { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29844" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P29844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29844" } ] } ] }, { "uniprot_ac": "P30665", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30665", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30665" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P30665", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30665" } ] } ] }, { "uniprot_ac": "P30771", "gene_name": "NAM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] } ] }, { "uniprot_ac": "P31380", "gene_name": "FUN30", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P31380", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31380" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P31380", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31380" } ] } ] }, { "uniprot_ac": "P32580", "gene_name": "SUV3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32580" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32580" } ] } ] }, { "uniprot_ac": "P32597", "gene_name": "STH1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32597" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P32597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32597" } ] } ] }, { "uniprot_ac": "P32639", "gene_name": "BRR2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32639" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32639" } ] } ] }, { "uniprot_ac": "P32644", "gene_name": "ECM32", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32644" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32644" } ] } ] }, { "uniprot_ac": "P32794", "gene_name": "AFG2", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32794" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P32794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32794" } ] } ] }, { "uniprot_ac": "P32807", "gene_name": "YKU70", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32807" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P32807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32807" } ] } ] }, { "uniprot_ac": "P32863", "gene_name": "RAD54", "activity": [ { 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} ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P38132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38132" } ] } ] }, { "uniprot_ac": "P38693", "gene_name": "PHO12", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P38693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38693" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P38693", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38693" } ] } ] }, { "uniprot_ac": "P38712", "gene_name": "RRP3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38712" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38712" } ] } ] 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"ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P60842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60842" } ] } ] }, { "uniprot_ac": "P60843", "gene_name": "Eif4a1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P60843", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60843" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P60843", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60843" } ] } ] }, { "uniprot_ac": "P61221", "gene_name": "ABCE1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61221", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61221" } ] } ] }, { "uniprot_ac": "P61222", "gene_name": "Abce1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61222" } 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phosphate.", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] } ] }, { "uniprot_ac": "P83967", "gene_name": "Act88F", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P83967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83967" } ] } ] }, { "uniprot_ac": "P90529", "gene_name": "ifdA", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P90529", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P90529" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P90529", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P90529" } ] } ] }, { "uniprot_ac": "P97310", "gene_name": "Mcm2", "activity": [ { "ec_number": 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"evidence": [ { "id": "Q55GW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55GW2" } ] } ] }, { "uniprot_ac": "Q569Z5", "gene_name": "Ddx46", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q569Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q569Z5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q569Z5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q569Z5" } ] } ] }, { "uniprot_ac": "Q587J7", "gene_name": "TDRD12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q587J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q587J7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q587J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q587J7" } ] } ] }, { "uniprot_ac": "Q5BJS0", "gene_name": "Dhx30", "activity": [ 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