{
"uniprot_canonical_ac": "P05177-1",
"uniprot_ac": "P05177",
"uniprot_id": "CP1A2_HUMAN",
"mass": {
"chemical_mass": 58407.0,
"monoisotopic_mass": 58407.0
},
"refseq": {
"ac": "NP_000752",
"name": "cytochrome P450 1A2",
"summary": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
"gene_names": [
{
"name": "CYP1A2",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P05177",
"id": "P05177"
},
{
"name": "CP12; CYPIA2; P3-450; P450(PA)",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752",
"id": "NP_000752"
},
{
"name": "CYP1A2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752",
"id": "NP_000752"
}
],
"protein_names": [
{
"name": "Cytochrome P450 1A2",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P05177"
},
{
"name": "1.14.14.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "4.2.1.152",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "CYPIA2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "Cholesterol 25-hydroxylase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "Cytochrome P(3)450",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "Cytochrome P450 4",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "Cytochrome P450-P3",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "Hydroperoxy icosatetraenoate dehydratase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P05177"
},
{
"name": "P450 form 4; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; microsomal monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; dioxin-inducible P3-450; cholesterol 25-hydroxylase; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; cytochrome P450, family 1, subfamily A, polypeptide 2; hydroperoxy icosatetraenoate dehydratase",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752",
"id": "NP_000752"
},
{
"name": "cytochrome P450 1A2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752",
"id": "NP_000752"
}
],
"function": [
{
"annotation": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:9435160, PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable).",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177#function"
},
{
"database": "PubMed",
"id": "14725854",
"url": "https://glygen.org/publication/PubMed/14725854"
},
{
"database": "PubMed",
"id": "11555828",
"url": "https://glygen.org/publication/PubMed/11555828"
},
{
"database": "PubMed",
"id": "9435160",
"url": "https://glygen.org/publication/PubMed/9435160"
},
{
"database": "PubMed",
"id": "16522833",
"url": "https://glygen.org/publication/PubMed/16522833"
},
{
"database": "PubMed",
"id": "10681376",
"url": "https://glygen.org/publication/PubMed/10681376"
},
{
"database": "PubMed",
"id": "21576599",
"url": "https://glygen.org/publication/PubMed/21576599"
},
{
"database": "PubMed",
"id": "19965576",
"url": "https://glygen.org/publication/PubMed/19965576"
},
{
"database": "PubMed",
"id": "12865317",
"url": "https://glygen.org/publication/PubMed/12865317"
},
{
"database": "PubMed",
"id": "21068195",
"url": "https://glygen.org/publication/PubMed/21068195"
}
]
},
{
"annotation": "CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
{
"database": "PubMed",
"id": "36701157",
"url": "https://glygen.org/publication/PubMed/36701157"
}
]
},
{
"annotation": "Determination of SNP frequencies in the CYP1A1_CYP1A2 locus.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
{
"database": "PubMed",
"id": "15643613",
"url": "https://glygen.org/publication/PubMed/15643613"
}
]
},
{
"annotation": "Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
{
"database": "PubMed",
"id": "37511239",
"url": "https://glygen.org/publication/PubMed/37511239"
}
]
},
{
"annotation": "Observational study of gene-disease association. (HuGE Navigator)",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
{
"database": "PubMed",
"id": "16609368",
"url": "https://glygen.org/publication/PubMed/16609368"
}
]
},
{
"annotation": "Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR. Review article Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
{
"database": "PubMed",
"id": "36011409",
"url": "https://glygen.org/publication/PubMed/36011409"
}
]
},
{
"annotation": "The influence of the CYP1A2-163 C>A polymorphism on the hemostatic response to exercise following caffeine supplementation.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
},
{
"database": "PubMed",
"id": "36239290",
"url": "https://glygen.org/publication/PubMed/36239290"
}
]
},
{
"annotation": "This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "rs145783435",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs145783435"
},
{
"id": "rs145783435",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs145783435#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 200,
"end_pos": 200,
"sequence_org": "I",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVI->NVT).",
"chr_id": "15",
"chr_pos": "74750337",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "I200",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P05177",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05177"
},
{
"id": "rs755082460",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755082460"
},
{
"id": "rs755082460",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755082460"
},
{
"id": "rs755082460",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs755082460"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 229,
"end_pos": 229,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (TAS->NAS).",
"chr_id": "15",
"chr_pos": "74750424",
"ref_nt": "C",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "T229",
"disease": [
{
"disease_id": "DOID:1319",
"recommended_name": {
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain cancer",
"description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain."
},
"synonyms": [
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "BT - Brain tumour",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "adult brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "adult malignant brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm, adult",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant brain tumour",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant primary brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant primary brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of Brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of adult brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary malignant neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "tumor of the Brain",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1038333951",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1038333951"
},
{
"id": "rs1038333951",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1038333951"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 277,
"end_pos": 277,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KNS->NNS).",
"chr_id": "15",
"chr_pos": "74750569",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K277",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P05177",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05177"
},
{
"id": "rs746644895",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746644895"
},
{
"id": "rs746644895",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746644895"
},
{
"id": "rs746644895",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746644895"
},
{
"id": "rs746644895",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs746644895"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 282,
"end_pos": 282,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DIT->NIT).",
"chr_id": "15",
"chr_pos": "74751201",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "D282",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
},
{
"disease_id": "DOID:4362",
"recommended_name": {
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervical cancer",
"description": "A female reproductive organ cancer that is located_in the cervix."
},
"synonyms": [
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervical neoplasm",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervix cancer",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "cervix uteri cancer",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "neoplasm of uterine cervix",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "tumor of the Cervix Uteri",
"description": ""
},
{
"id": "DOID:4362",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4362",
"name": "uterine cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervical cancer",
"description": "A primary or metastatic malignant neoplasm involving the cervix."
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "tumor of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "tumour of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "uterine cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cancer of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervical cancer, somatic",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervix cancer",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "cervix uteri cancer",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervical neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervical tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervical tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix uteri neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix uteri tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant cervix uteri tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of the cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of the uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant neoplasm of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of the cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of the uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumor of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of the cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of the cervix uteri",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of the uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant tumour of uterine cervix",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant uterine cervix neoplasm",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant uterine cervix tumor",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "malignant uterine cervix tumour",
"description": ""
},
{
"id": "MONDO:0002974",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0002974",
"name": "uterine cervix cancer",
"description": ""
},
{
"id": "MIM:603956",
"resource": "MIM",
"url": "https://www.omim.org/entry/603956",
"name": "Cervical cancer",
"description": "Cervical cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs762114920",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762114920"
},
{
"id": "rs762114920",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762114920"
},
{
"id": "rs762114920",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs762114920"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 289,
"end_pos": 289,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KHS->NHS).",
"chr_id": "15",
"chr_pos": "74751224",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K289",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs756936781",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756936781"
},
{
"id": "rs756936781",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756936781"
},
{
"id": "rs756936781",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs756936781"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 302,
"end_pos": 302,
"sequence_org": "I",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLI->NLT).",
"chr_id": "15",
"chr_pos": "74751262",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "I302",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs557412265",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs557412265"
},
{
"id": "rs557412265",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs557412265"
},
{
"id": "rs557412265",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs557412265"
},
{
"id": "rs557412265",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs557412265#frequency_tab"
},
{
"id": "rs557412265",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs557412265"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 388,
"end_pos": 388,
"sequence_org": "H",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HST->NST).",
"chr_id": "15",
"chr_pos": "74752243",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "0.0002",
"site_lbl": "H388",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P05177",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05177"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 393,
"end_pos": 393,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DTT->NTT).",
"chr_id": "15",
"chr_pos": "74753194",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "D393",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs144148965",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs144148965"
},
{
"id": "rs144148965",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs144148965"
},
{
"id": "rs144148965",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs144148965"
},
{
"id": "rs144148965",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs144148965#frequency_tab"
},
{
"id": "rs144148965",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs144148965"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 436,
"end_pos": 436,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGT->NGT).",
"chr_id": "15",
"chr_pos": "74754843",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "0.0002",
"site_lbl": "D436",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P05177",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05177"
},
{
"id": "rs763531887",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763531887"
},
{
"id": "rs763531887",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763531887"
},
{
"id": "rs763531887",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763531887"
},
{
"id": "rs763531887",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs763531887"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 490,
"end_pos": 490,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DLT->NLT).",
"chr_id": "15",
"chr_pos": "74755005",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "D490",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1031668682",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1031668682"
},
{
"id": "rs1031668682",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1031668682#frequency_tab"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 69,
"end_pos": 69,
"sequence_org": "S",
"sequence_mut": "G",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->G).",
"chr_id": "15",
"chr_pos": "74749943",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S69",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P05177",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05177"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 83,
"end_pos": 83,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "M",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).",
"chr_id": "15",
"chr_pos": "74749986",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "T83",
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
},
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
},
{
"disease_id": "DOID:2531",
"recommended_name": {
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematologic cancer",
"description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes."
},
"synonyms": [
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "Hematologic malignancy",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "Hematologic neoplasm",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "Hematological tumors",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "blood cancer",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic and lymphoid system tumor",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic cancer",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic neoplasm",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "hematopoietic tumors",
"description": ""
},
{
"id": "DOID:2531",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:2531",
"name": "malignant hematopoietic neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
}
],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "64.59",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "67.83",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "51.41",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "67.99",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "48.94",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "44.72",
"present": "ABSENT",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "66.68",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "49.76",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "65.35",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "66.51",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "89.85",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "39.77",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "45.32",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P05177"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
]
}
],
"species": [
{
"name": "Homo sapiens",
"taxid": 9606,
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"common_name": "Human"
}
],
"gene": [
{
"name": "CYP1A2",
"url": "https://www.uniprot.org/uniprot/P05177",
"locus": {
"chromosome": "15",
"start_pos": 74756607,
"end_pos": 74748845,
"strand": "-",
"evidence": [
{
"database": "Ensembl Gene",
"id": "ENSG00000140505",
"url": "https://www.ensembl.org/id/ENSG00000140505"
}
]
}
}
],
"crossref": [
{
"id": "ENSG00000140505",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000140505",
"database": "Bgee",
"categories": [
"Gene Expression"
]
},
{
"id": "P05177",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P05177",
"database": "BioMuta",
"categories": [
"Variation"
]
},
{
"id": "1.14.14.1",
"url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.14.1&UniProtAcc=P05177",
"database": "BRENDA",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "1.14.99.38",
"url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.99.38&UniProtAcc=P05177",
"database": "BRENDA",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "cd20676",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20676",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "CHEMBL3356",
"url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3356",
"database": "ChEMBL",
"categories": [
"Other"
]
},
{
"id": "CYP1A2",
"url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP1A2",
"database": "GeneCards",
"categories": [
"Gene Annotation",
"Organism-specific"
]
},
{
"id": "1544",
"url": "https://www.ncbi.nlm.nih.gov/gene/1544",
"database": "GeneID",
"categories": [
"Genome Annotation"
]
},
{
"id": "2596",
"url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2596",
"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "P05177",
"url": "https://www.ebi.ac.uk/intact/interactors/id:P05177*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR001128",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001128",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR002401",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR002401",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR008066",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR008066",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR017972",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR017972",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR036396",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR036396",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:1544",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1544",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "108330",
"url": "http://www.omim.org/entry/108330",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "124060",
"url": "http://www.omim.org/entry/124060",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_P05177",
"url": "https://www.nextprot.org/entry/NX_P05177",
"database": "neXtProt",
"categories": [
"Protein",
"Organism-specific"
]
},
{
"id": "AKWEIFL",
"url": "https://omabrowser.org/oma/group/AKWEIFL/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "2900138at2759",
"url": "http://www.orthodb.org/?query=2900138at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR24289",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24289",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR24289:SF13",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24289:SF13",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "2HI4",
"url": "https://www.rcsb.org/structure/2HI4",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00067",
"url": "http://pfam.xfam.org/family/PF00067",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "P05177",
"url": "https://pharos.nih.gov/targets/P05177",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR_P05177",
"url": "http://purl.obolibrary.org/obo/PR_P05177",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-211957",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211957",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-2142670",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9027307",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "17149",
"url": "https://www.rhea-db.org/rhea/17149",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "37947",
"url": "https://www.rhea-db.org/rhea/37947",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "39759",
"url": "https://www.rhea-db.org/rhea/39759",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "39779",
"url": "https://www.rhea-db.org/rhea/39779",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "42088",
"url": "https://www.rhea-db.org/rhea/42088",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "42092",
"url": "https://www.rhea-db.org/rhea/42092",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "47208",
"url": "https://www.rhea-db.org/rhea/47208",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "47212",
"url": "https://www.rhea-db.org/rhea/47212",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "47280",
"url": "https://www.rhea-db.org/rhea/47280",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "47292",
"url": "https://www.rhea-db.org/rhea/47292",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "48632",
"url": "https://www.rhea-db.org/rhea/48632",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "48636",
"url": "https://www.rhea-db.org/rhea/48636",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "48716",
"url": "https://www.rhea-db.org/rhea/48716",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "49856",
"url": "https://www.rhea-db.org/rhea/49856",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "49860",
"url": "https://www.rhea-db.org/rhea/49860",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "50256",
"url": "https://www.rhea-db.org/rhea/50256",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "52120",
"url": "https://www.rhea-db.org/rhea/52120",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "52284",
"url": "https://www.rhea-db.org/rhea/52284",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "52292",
"url": "https://www.rhea-db.org/rhea/52292",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P05177-1",
"url": "https://www.uniprot.org/uniprot/P05177-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN",
"length": 516,
"header": "sp|P05177-1|CP1A2_HUMAN Isoform 1 of Cytochrome P450 1A2 OS=Homo sapiens OX=9606 GN=CYP1A2 PE=1 SV=4 CANONICAL=P05177-1"
},
"isoforms": [
{
"isoform_ac": "P05177-1",
"url": "",
"sequence": {
"sequence": "MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN",
"length": 516,
"header": "sp|P05177-1|CP1A2_HUMAN Isoform 1 of Cytochrome P450 1A2 OS=Homo sapiens OX=9606 GN=CYP1A2 PE=1 SV=4 CANONICAL=P05177-1"
},
"locus": {
"chromosome": "15",
"start_pos": 74755085,
"end_pos": 74749739,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000343932.5",
"url": "https://www.ensembl.org/id/ENST00000343932.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000342007.4",
"url": "https://www.ensembl.org/id/ENSP00000342007.4"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "predicted",
"site_seq": "S",
"relation": "attached",
"comment": "O-linked (GlcNAc) serine O-GlcNAcylation",
"start_pos": 69,
"start_aa": "Ser",
"end_pos": 69,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser69",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177#ptm_processing"
}
]
}
],
"phosphorylation": [
{
"start_pos": 82,
"end_pos": 82,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P05177",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05177"
},
{
"database": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
}
],
"site_lbl": "Ser82"
}
],
"glycation": [],
"keywords": [
"enzyme",
"glycoprotein",
"glycoprotein_predicted"
],
"publication": [
{
"title": "Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase.",
"journal": "Annual review of pharmacology and toxicology",
"date": "1999",
"authors": "Weinshilboum RM, Otterness DM, Szumlanski CL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "10331075",
"url": "https://glygen.org/publication/PubMed/10331075"
}
]
},
{
"title": "Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Halim AB, LeGros L, Geller A, Kotb M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "10514445",
"url": "https://glygen.org/publication/PubMed/10514445"
}
]
},
{
"title": "Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II).",
"journal": "The Journal of biological chemistry",
"date": "2000",
"authors": "LeGros HL Jr, Halim AB, Geller AM, Kotb M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "10644686",
"url": "https://glygen.org/publication/PubMed/10644686"
}
]
},
{
"title": "Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.",
"journal": "Drug metabolism and disposition: the biological fate of chemicals",
"date": "2000-03",
"authors": "Chen H, Howald W N, Juchau M R",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "10681376",
"url": "https://glygen.org/publication/PubMed/10681376"
}
]
},
{
"title": "Interaction of flavodoxin with cobalamin-dependent methionine synthase.",
"journal": "Biochemistry",
"date": "2000",
"authors": "Hall DA, Jordan-Starck TC, Loo RO, Ludwig ML, Matthews RG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "10978155",
"url": "https://glygen.org/publication/PubMed/10978155"
}
]
},
{
"title": "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.",
"journal": "Pharmacogenetics",
"date": "2001",
"authors": "Corchero J, Pimprale S, Kimura S, Gonzalez F J",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "11207026",
"url": "https://glygen.org/publication/PubMed/11207026"
}
]
},
{
"title": "Five novel natural allelic variants-951A>C, 1042G>A (D348N), 1156A>T (I386F), 1217G>A (C406Y) and 1291C>T (C431Y)-of the human CYP1A2 gene in a French Caucasian population.",
"journal": "Human mutation",
"date": "2001",
"authors": "Chevalier D, Cauffiez C, Allorge D, Lo-Guidice JM, Lhermitte M, Lafitte JJ, Broly F",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "11295848",
"url": "https://glygen.org/publication/PubMed/11295848"
}
]
},
{
"title": "Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.",
"journal": "Chemical research in toxicology",
"date": "2001",
"authors": "Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "11409944",
"url": "https://glygen.org/publication/PubMed/11409944"
}
]
},
{
"title": "Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily.",
"journal": "Chemical research in toxicology",
"date": "2001",
"authors": "Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "11511179",
"url": "https://glygen.org/publication/PubMed/11511179"
}
]
},
{
"title": "Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.",
"journal": "Metabolism: clinical and experimental",
"date": "2001",
"authors": "Badawi AF, Cavalieri EL, Rogan EG",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "11555828",
"url": "https://glygen.org/publication/PubMed/11555828"
}
]
},
{
"title": "The 3-D structure of microsomal glutathione transferase 1 at 6 A resolution as determined by electron crystallography of p22(1)2(1) crystals.",
"journal": "Biochimica et biophysica acta",
"date": "2002",
"authors": "Holm PJ, Morgenstern R, Hebert H",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "11904223",
"url": "https://glygen.org/publication/PubMed/11904223"
}
]
},
{
"title": "Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis.",
"journal": "Journal of molecular biology",
"date": "2002",
"authors": "Nitanai Y, Satow Y, Adachi H, Tsujimoto M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "12144777",
"url": "https://glygen.org/publication/PubMed/12144777"
}
]
},
{
"title": "Regulation of mammalian liver methionine adenosyltransferase.",
"journal": "The Journal of nutrition",
"date": "2002",
"authors": "Corrales FJ, Perez-Mato I, Sanchez Del Pino MM, Ruiz F, Castro C, Garcia-Trevijano ER, Latasa U, Martinez-Chantar ML, Martinez-Cruz A, Avila MA, Mato JM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "12163696",
"url": "https://glygen.org/publication/PubMed/12163696"
}
]
},
{
"title": "Prostaglandin and leukotriene omega-hydroxylases.",
"journal": "Prostaglandins & other lipid mediators",
"date": "2002",
"authors": "Kikuta Y, Kusunose E, Kusunose M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816"
}
],
"reference": [
{
"type": "PubMed",
"id": "12432928",
"url": "https://glygen.org/publication/PubMed/12432928"
}
]
},
{
"title": "Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas.",
"journal": "Prostaglandins, leukotrienes, and essential fatty acids",
"date": "2002",
"authors": "Werner K, Schaefer WR, Schweer H, Deppert WR, Karck U, Zahradnik HP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142670",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670"
}
],
"reference": [
{
"type": "PubMed",
"id": "12468260",
"url": "https://glygen.org/publication/PubMed/12468260"
}
]
},
{
"title": "Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681"
}
],
"reference": [
{
"type": "PubMed",
"id": "12590139",
"url": "https://glygen.org/publication/PubMed/12590139"
}
]
},
{
"title": "Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions.",
"journal": "Biochemistry",
"date": "2003",
"authors": "Yang X, Hu Y, Yin DH, Turner MA, Wang M, Borchardt RT, Howell PL, Kuczera K, Schowen RL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "12590576",
"url": "https://glygen.org/publication/PubMed/12590576"
}
]
},
{
"title": "Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter.",
"journal": "Carcinogenesis",
"date": "2003",
"authors": "Ellis EM, Slattery CM, Hayes JD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "12727802",
"url": "https://glygen.org/publication/PubMed/12727802"
}
]
},
{
"title": "Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.",
"journal": "Endocrinology",
"date": "2003-08",
"authors": "Lee Anthony J, Cai May Xiaoxin, Thomas Paul E, Conney Allan H, Zhu Bao Ting",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "12865317",
"url": "https://glygen.org/publication/PubMed/12865317"
}
]
},
{
"title": "Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Lindner HA, Lunin VV, Alary A, Hecker R, Cygler M, Menard R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "12933810",
"url": "https://glygen.org/publication/PubMed/12933810"
}
]
},
{
"title": "Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues.",
"journal": "The Journal of biological chemistry",
"date": "1963",
"authors": "REMY CN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "13981612",
"url": "https://glygen.org/publication/PubMed/13981612"
}
]
},
{
"title": "Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.",
"journal": "The Journal of pharmacology and experimental therapeutics",
"date": "2004",
"authors": "Murayama N, Soyama A, Saito Y, Nakajima Y, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Ozawa S, Sawada J",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "14563787",
"url": "https://glygen.org/publication/PubMed/14563787"
}
]
},
{
"title": "CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816"
}
],
"reference": [
{
"type": "PubMed",
"id": "14660610",
"url": "https://glygen.org/publication/PubMed/14660610"
}
]
},
{
"title": "Functional characterization of four allelic variants of human cytochrome P450 1A2.",
"journal": "Archives of biochemistry and biophysics",
"date": "2004",
"authors": "Zhou H, Josephy PD, Kim D, Guengerich FP",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "14725854",
"url": "https://glygen.org/publication/PubMed/14725854"
}
]
},
{
"title": "The endo-8,9-epoxide of aflatoxin B1: a new metabolite.",
"journal": "Chemical research in toxicology",
"date": "1992",
"authors": "Raney KD, Coles B, Guengerich FP, Harris TM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "1504254",
"url": "https://glygen.org/publication/PubMed/1504254"
}
]
},
{
"title": "Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis.",
"journal": "Biochemistry",
"date": "2004",
"authors": "Gomez GA, Morisseau C, Hammock BD, Christianson DW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142670",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670"
}
],
"reference": [
{
"type": "PubMed",
"id": "15096040",
"url": "https://glygen.org/publication/PubMed/15096040"
}
]
},
{
"title": "Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1.",
"journal": "Drug metabolism and disposition: the biological fate of chemicals",
"date": "2004",
"authors": "Choudhary D, Jansson I, Stoilov I, Sarfarazi M, Schenkman JB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816"
}
],
"reference": [
{
"type": "PubMed",
"id": "15258110",
"url": "https://glygen.org/publication/PubMed/15258110"
}
]
},
{
"title": "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.",
"journal": "Pharmacogenomics",
"date": "2004",
"authors": "Solus JF, Arietta BJ, Harris JR, Sexton DP, Steward JQ, McMunn C, Ihrie P, Mehall JM, Edwards TL, Dawson EP",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "15469410",
"url": "https://glygen.org/publication/PubMed/15469410"
}
]
},
{
"title": "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.",
"journal": "Circulation",
"date": "2005",
"authors": "Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816"
}
],
"reference": [
{
"type": "PubMed",
"id": "15611369",
"url": "https://glygen.org/publication/PubMed/15611369"
}
]
},
{
"title": "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.",
"journal": "Hum. Mutat.",
"date": "2005",
"authors": "Jiang Z, Dalton TP, Jin L, Wang B, Tsuneoka Y, Shertzer HG, Deka R, Nebert DW",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
},
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
],
"reference": [
{
"type": "PubMed",
"id": "15643613",
"url": "https://glygen.org/publication/PubMed/15643613"
}
]
},
{
"title": "Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.",
"journal": "Drug metabolism and pharmacokinetics",
"date": "2005",
"authors": "Soyama A, Saito Y, Hanioka N, Maekawa K, Komamura K, Kamakura S, Kitakaze M, Tomoike H, Ueno K, Goto Y, Kimura H, Katoh M, Sugai K, Saitoh O, Kawai M, Ohnuma T, Ohtsuki T, Suzuki C, Minami N, Kamatani N, Ozawa S, Sawada J",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "15770072",
"url": "https://glygen.org/publication/PubMed/15770072"
}
]
},
{
"title": "Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.",
"journal": "Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver",
"date": "2005",
"authors": "Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "15788214",
"url": "https://glygen.org/publication/PubMed/15788214"
}
]
},
{
"title": "The thiopurines: an update.",
"journal": "Investigational new drugs",
"date": "2005",
"authors": "Coulthard S, Hogarth L",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "16267626",
"url": "https://glygen.org/publication/PubMed/16267626"
}
]
},
{
"title": "Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.",
"journal": "International journal of cancer",
"date": "2006",
"authors": "He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "16385575",
"url": "https://glygen.org/publication/PubMed/16385575"
}
]
},
{
"title": "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies.",
"journal": "The Journal of biological chemistry",
"date": "2006",
"authors": "Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "16407288",
"url": "https://glygen.org/publication/PubMed/16407288"
}
]
},
{
"title": "Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2006",
"authors": "Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681"
}
],
"reference": [
{
"type": "PubMed",
"id": "16424216",
"url": "https://glygen.org/publication/PubMed/16424216"
}
]
},
{
"title": "Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1.",
"journal": "Chemical research in toxicology",
"date": "1992",
"authors": "Raney KD, Shimada T, Kim DH, Groopman JD, Harris TM, Guengerich FP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "1643250",
"url": "https://glygen.org/publication/PubMed/1643250"
}
]
},
{
"title": "Coffee, CYP1A2 genotype, and risk of myocardial infarction.",
"journal": "JAMA",
"date": "2006-03-08",
"authors": "Cornelis Marilyn C, El-Sohemy Ahmed, Kabagambe Edmond K, Campos Hannia",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "16522833",
"url": "https://glygen.org/publication/PubMed/16522833"
}
]
},
{
"title": "Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.",
"journal": "Pharmacogenetics and genomics",
"date": "2006",
"authors": "Jiang Z, Dragin N, Jorge-Nebert LF, Martin MV, Guengerich FP, Aklillu E, Ingelman-Sundberg M, Hammons GJ, Lyn-Cook BD, Kadlubar FF, Saldana SN, Sorter M, Vinks AA, Nassr N, von Richter O, Jin L, Nebert DW",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
],
"reference": [
{
"type": "PubMed",
"id": "16609368",
"url": "https://glygen.org/publication/PubMed/16609368"
}
]
},
{
"title": "Aldo-keto reductases and bioactivation/detoxication.",
"journal": "Annual review of pharmacology and toxicology",
"date": "2007",
"authors": "Jin Y, Penning TM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "16970545",
"url": "https://glygen.org/publication/PubMed/16970545"
}
]
},
{
"title": "Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.",
"journal": "J. Biol. Chem.",
"date": "2007",
"authors": "Sansen Stefaan, Yano Jason K, Reynald Rosamund L, Schoch Guillaume A, Griffin Keith J, Stout C David, Johnson Eric F",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "17311915",
"url": "https://glygen.org/publication/PubMed/17311915"
}
]
},
{
"title": "The human gamma-glutamyltransferase gene family.",
"journal": "Human genetics",
"date": "2008",
"authors": "Heisterkamp N, Groffen J, Warburton D, Sneddon TP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "18357469",
"url": "https://glygen.org/publication/PubMed/18357469"
}
]
},
{
"title": "Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3.",
"journal": "Chemical research in toxicology",
"date": "2008",
"authors": "Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "18416522",
"url": "https://glygen.org/publication/PubMed/18416522"
}
]
},
{
"title": "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.",
"journal": "FEBS letters",
"date": "2008",
"authors": "Figaro S, Scrima N, Buckingham RH, Heurgue-Hamard V",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "18539146",
"url": "https://glygen.org/publication/PubMed/18539146"
}
]
},
{
"title": "Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.",
"journal": "Carcinogenesis",
"date": "1991",
"authors": "Turesky RJ, Lang NP, Butler MA, Teitel CH, Kadlubar FF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-211957",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211957"
}
],
"reference": [
{
"type": "PubMed",
"id": "1934265",
"url": "https://glygen.org/publication/PubMed/1934265"
}
]
},
{
"title": "Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit.",
"journal": "The Journal of biological chemistry",
"date": "1977",
"authors": "Tate SS, Ross ME",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "19463",
"url": "https://glygen.org/publication/PubMed/19463"
}
]
},
{
"title": "Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation.",
"journal": "FEBS letters",
"date": "2009",
"authors": "Chen P, Fenet B, Michaud S, Tomczyk N, Vericel E, Lagarde M, Guichardant M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681"
}
],
"reference": [
{
"type": "PubMed",
"id": "19818771",
"url": "https://glygen.org/publication/PubMed/19818771"
}
]
},
{
"title": "Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.",
"journal": "Journal of lipid research",
"date": "2010-05",
"authors": "Lucas Dani\u00e8le, Goulitquer Sophie, Marienhagen Jan, Fer Maude, Dreano Yvonne, Schwaneberg Ulrich, Amet Yolande, Corcos Laurent",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "19965576",
"url": "https://glygen.org/publication/PubMed/19965576"
}
]
},
{
"title": "Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing.",
"journal": "Journal of lipid research",
"date": "2010",
"authors": "Lu Y, Tian H, Hong S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9027307",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307"
}
],
"reference": [
{
"type": "PubMed",
"id": "19965612",
"url": "https://glygen.org/publication/PubMed/19965612"
}
]
},
{
"title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.",
"journal": "Electrophoresis",
"date": "2010",
"authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H",
"evidence": [
{
"database": "iPTMnet",
"id": "P05177",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
}
]
},
{
"title": "Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.",
"journal": "Drug metabolism and disposition: the biological fate of chemicals",
"date": "2011",
"authors": "Bui P, Imaizumi S, Beedanagari SR, Reddy ST, Hankinson O",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "21068195",
"url": "https://glygen.org/publication/PubMed/21068195"
}
]
},
{
"title": "14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds.",
"journal": "The Journal of biological chemistry",
"date": "2011",
"authors": "Tian H, Lu Y, Shah SP, Hong S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9027307",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307"
}
],
"reference": [
{
"type": "PubMed",
"id": "21112969",
"url": "https://glygen.org/publication/PubMed/21112969"
}
]
},
{
"title": "Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity.",
"journal": "Environmental health perspectives",
"date": "2011",
"authors": "Ren X, Aleshin M, Jo WJ, Dills R, Kalman DA, Vulpe CD, Smith MT, Zhang L",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "21193388",
"url": "https://glygen.org/publication/PubMed/21193388"
}
]
},
{
"title": "Cholesterol 25-hydroxylation activity of CYP3A.",
"journal": "Journal of lipid research",
"date": "2011-08",
"authors": "Honda Akira, Miyazaki Teruo, Ikegami Tadashi, Iwamoto Junichi, Maeda Tomomi, Hirayama Takeshi, Saito Yoshifumi, Teramoto Tamio, Matsuzaki Yasushi",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "21576599",
"url": "https://glygen.org/publication/PubMed/21576599"
}
]
},
{
"title": "Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions.",
"journal": "The American journal of pathology",
"date": "2011",
"authors": "Tian H, Lu Y, Shah SP, Hong S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9027307",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307"
}
],
"reference": [
{
"type": "PubMed",
"id": "21839062",
"url": "https://glygen.org/publication/PubMed/21839062"
}
]
},
{
"title": "Novel proresolving aspirin-triggered DHA pathway.",
"journal": "Chemistry & biology",
"date": "2011",
"authors": "Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681"
}
],
"reference": [
{
"type": "PubMed",
"id": "21867913",
"url": "https://glygen.org/publication/PubMed/21867913"
}
]
},
{
"title": "Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2013",
"authors": "Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Galvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN, Nebert DW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681"
}
],
"reference": [
{
"type": "PubMed",
"id": "23956430",
"url": "https://glygen.org/publication/PubMed/23956430"
}
]
},
{
"title": "Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia.",
"journal": "Iranian journal of pediatric hematology and oncology",
"date": "2014",
"authors": "Azimi F, Jafariyan M, Khatami S, Mortazavi Y, Azad M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "24734162",
"url": "https://glygen.org/publication/PubMed/24734162"
}
]
},
{
"title": "Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages.",
"journal": "Chemistry & biology",
"date": "2014",
"authors": "Hong S, Lu Y, Tian H, Alapure BV, Wang Q, Bunnell BA, Laborde JM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9027307",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307"
}
],
"reference": [
{
"type": "PubMed",
"id": "25200603",
"url": "https://glygen.org/publication/PubMed/25200603"
}
]
},
{
"title": "Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1.",
"journal": "Journal of natural products",
"date": "2014",
"authors": "Tungen JE, Aursnes M, Vik A, Ramon S, Colas RA, Dalli J, Serhan CN, Hansen TV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9018681",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681"
}
],
"reference": [
{
"type": "PubMed",
"id": "25247845",
"url": "https://glygen.org/publication/PubMed/25247845"
}
]
},
{
"title": "Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney.",
"journal": "Biochemical and biophysical research communications",
"date": "1989",
"authors": "Pawlak A, Wu SJ, Bulle F, Suzuki A, Chikhi N, Ferry N, Baik JH, Siegrist S, Guellaen G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "2573352",
"url": "https://glygen.org/publication/PubMed/2573352"
}
]
},
{
"title": "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.",
"journal": "Mol. Endocrinol.",
"date": "1989",
"authors": "Ikeya K, Jaiswal A K, Owens R A, Jones J E, Nebert D W, Kimura S",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "2575218",
"url": "https://glygen.org/publication/PubMed/2575218"
}
]
},
{
"title": "Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.",
"journal": "Nat. Commun.",
"date": "2016",
"authors": "Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "26988023",
"url": "https://glygen.org/publication/PubMed/26988023"
}
]
},
{
"title": "A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.",
"journal": "Biochemistry",
"date": "2016",
"authors": "van Haren MJ, Sastre Torano J, Sartini D, Emanuelli M, Parsons RB, Martin NI",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "27570878",
"url": "https://glygen.org/publication/PubMed/27570878"
}
]
},
{
"title": "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.",
"journal": "DNA",
"date": "1985",
"authors": "Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "3000715",
"url": "https://glygen.org/publication/PubMed/3000715"
}
]
},
{
"title": "Gene expression of rat and human microsomal glutathione S-transferases.",
"journal": "The Journal of biological chemistry",
"date": "1988",
"authors": "DeJong JL, Morgenstern R, Jornvall H, DePierre JW, Tu CP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "3372534",
"url": "https://glygen.org/publication/PubMed/3372534"
}
]
},
{
"title": "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "1986",
"authors": "Quattrochi L C, Pendurthi U R, Okino S T, Potenza C, Tukey R H",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "3462722",
"url": "https://glygen.org/publication/PubMed/3462722"
}
]
},
{
"title": "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.",
"journal": "Mol. Pharmacol.",
"date": "1986",
"authors": "Wrighton S A, Campanile C, Thomas P E, Maines S L, Watkins P B, Parker G, Mendez-Picon G, Haniu M, Shively J E, Levin W",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "3517618",
"url": "https://glygen.org/publication/PubMed/3517618"
}
]
},
{
"title": "Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR.",
"journal": "Genes",
"date": "2022",
"authors": "Barati S, Fabrizio C, Strafella C, Cascella R, Caputo V, Megalizzi D, Peconi C, Mela J, Colantoni L, Caltagirone C, Termine A, Giardina E",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
],
"reference": [
{
"type": "PubMed",
"id": "36011409",
"url": "https://glygen.org/publication/PubMed/36011409"
}
]
},
{
"title": "The influence of the CYP1A2-163 C>A polymorphism on the hemostatic response to exercise following caffeine supplementation.",
"journal": "The Journal of sports medicine and physical fitness",
"date": "2022-10-14",
"authors": "Aiello Joseph J, Nagelkirk Paul R, Sackett James R, Fitzgerald Liam F, Hargens Trent A, Saunders Michael J, El-Sohemy Ahmed, Womack Christopher J",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
],
"reference": [
{
"type": "PubMed",
"id": "36239290",
"url": "https://glygen.org/publication/PubMed/36239290"
}
]
},
{
"title": "CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction.",
"journal": "JAMA network open",
"date": "2023-01-03",
"authors": "Mahdavi Sara, Palatini Paolo, El-Sohemy Ahmed",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
],
"reference": [
{
"type": "PubMed",
"id": "36701157",
"url": "https://glygen.org/publication/PubMed/36701157"
}
]
},
{
"title": "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.",
"journal": "J. Exp. Pathol.",
"date": "1987",
"authors": "Jaiswal A K, Nebert D W, McBride O W, Gonzalez F J",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "3681487",
"url": "https://glygen.org/publication/PubMed/3681487"
}
]
},
{
"title": "Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations.",
"journal": "International journal of molecular sciences",
"date": "2023-07-14",
"authors": "Dutkiewicz Zbigniew, Mikstacka Renata",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000752",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000752"
}
],
"reference": [
{
"type": "PubMed",
"id": "37511239",
"url": "https://glygen.org/publication/PubMed/37511239"
}
]
},
{
"title": "Human P3(450): cDNA and complete amino acid sequence.",
"journal": "Nucleic Acids Res.",
"date": "1986",
"authors": "Jaiswal A K, Nebert D W, Gonzalez F J",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "3755823",
"url": "https://glygen.org/publication/PubMed/3755823"
}
]
},
{
"title": "Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1985",
"authors": "Groopman JD, Donahue PR, Zhu JQ, Chen JS, Wogan GN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "3931076",
"url": "https://glygen.org/publication/PubMed/3931076"
}
]
},
{
"title": "Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes.",
"journal": "Archives of biochemistry and biophysics",
"date": "1995",
"authors": "Rifkind AB, Lee C, Chang TK, Waxman DJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142670",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670"
}
],
"reference": [
{
"type": "PubMed",
"id": "7625847",
"url": "https://glygen.org/publication/PubMed/7625847"
}
]
},
{
"title": "Gene structural analysis and expression of human renal dipeptidase.",
"journal": "Biotechnology progress",
"date": "1994",
"authors": "Satoh S, Ohtsuka K, Keida Y, Kusunoki C, Konta Y, Niwa M, Kohsaka M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "7764673",
"url": "https://glygen.org/publication/PubMed/7764673"
}
]
},
{
"title": "Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes.",
"journal": "Chemical research in toxicology",
"date": "1995",
"authors": "Ueng YF, Shimada T, Yamazaki H, Guengerich FP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "7766804",
"url": "https://glygen.org/publication/PubMed/7766804"
}
]
},
{
"title": "Cloning and structural analysis of genomic DNA for human renal dipeptidase.",
"journal": "Biochimica et biophysica acta",
"date": "1993",
"authors": "Satoh S, Kusunoki C, Konta Y, Niwa M, Kohsaka M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "8439558",
"url": "https://glygen.org/publication/PubMed/8439558"
}
]
},
{
"title": "Determination of P4501A2 activity in human liver microsomes using [3-14C-methyl]caffeine.",
"journal": "Xenobiotica; the fate of foreign compounds in biological systems",
"date": "1995",
"authors": "Bloomer JC, Clarke SE, Chenery RJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-211957",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211957"
}
],
"reference": [
{
"type": "PubMed",
"id": "8553685",
"url": "https://glygen.org/publication/PubMed/8553685"
}
]
},
{
"title": "Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142670",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670"
}
],
"reference": [
{
"type": "PubMed",
"id": "8631948",
"url": "https://glygen.org/publication/PubMed/8631948"
}
]
},
{
"title": "Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Jakobsson PJ, Mancini JA, Ford-Hutchinson AW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "8703034",
"url": "https://glygen.org/publication/PubMed/8703034"
}
]
},
{
"title": "Structural organization of the human microsomal glutathione S-transferase gene (GST12).",
"journal": "Genomics",
"date": "1996",
"authors": "Kelner MJ, Stokely MN, Stovall NE, Montoya MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "8812420",
"url": "https://glygen.org/publication/PubMed/8812420"
}
]
},
{
"title": "Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.",
"journal": "Human molecular genetics",
"date": "1996",
"authors": "Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R, Gravel RA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "8968737",
"url": "https://glygen.org/publication/PubMed/8968737"
}
]
},
{
"title": "The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4.",
"journal": "Toxicology and applied pharmacology",
"date": "1996",
"authors": "Gallagher EP, Kunze KL, Stapleton PL, Eaton DL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "8975785",
"url": "https://glygen.org/publication/PubMed/8975785"
}
]
},
{
"title": "Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes.",
"journal": "Carcinogenesis",
"date": "1997",
"authors": "Hammons GJ, Milton D, Stepps K, Guengerich FP, Tukey RH, Kadlubar FF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-211957",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211957"
}
],
"reference": [
{
"type": "PubMed",
"id": "9111224",
"url": "https://glygen.org/publication/PubMed/9111224"
}
]
},
{
"title": "S-adenosylmethionine synthesis: molecular mechanisms and clinical implications.",
"journal": "Pharmacology & therapeutics",
"date": "1997",
"authors": "Mato JM, Alvarez L, Ortiz P, Pajares MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "9175157",
"url": "https://glygen.org/publication/PubMed/9175157"
}
]
},
{
"title": "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "9278457",
"url": "https://glygen.org/publication/PubMed/9278457"
}
]
},
{
"title": "Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.",
"journal": "The Journal of pharmacology and experimental therapeutics",
"date": "1998",
"authors": "Bylund J, Kunz T, Valmsen K, Oliw EH",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
},
{
"database": "Reactome",
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816"
}
],
"reference": [
{
"type": "PubMed",
"id": "9435160",
"url": "https://glygen.org/publication/PubMed/9435160"
}
]
},
{
"title": "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.",
"journal": "The Biochemical journal",
"date": "1998",
"authors": "Ireland LS, Harrison DJ, Neal GE, Hayes JD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5423646",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646"
}
],
"reference": [
{
"type": "PubMed",
"id": "9576847",
"url": "https://glygen.org/publication/PubMed/9576847"
}
]
},
{
"title": "Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.",
"journal": "Nature structural biology",
"date": "1998",
"authors": "Turner MA, Yuan CS, Borchardt RT, Hershfield MS, Smith GD, Howell PL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-156581",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581"
}
],
"reference": [
{
"type": "PubMed",
"id": "9586999",
"url": "https://glygen.org/publication/PubMed/9586999"
}
]
},
{
"title": "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.",
"journal": "The Journal of pharmacology and experimental therapeutics",
"date": "1998",
"authors": "Powell PK, Wolf I, Jin R, Lasker JM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142816",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816"
}
],
"reference": [
{
"type": "PubMed",
"id": "9618440",
"url": "https://glygen.org/publication/PubMed/9618440"
}
]
},
{
"title": "Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS.",
"journal": "Analytical biochemistry",
"date": "1998",
"authors": "Bylund J, Ericsson J, Oliw EH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2142670",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670"
}
],
"reference": [
{
"type": "PubMed",
"id": "9866708",
"url": "https://glygen.org/publication/PubMed/9866708"
}
]
},
{
"title": "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.",
"journal": "Drug metabolism and disposition: the biological fate of chemicals",
"date": "1999",
"authors": "Huang JD, Guo WC, Lai MD, Guo YL, Lambert GH",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"reference": [
{
"type": "PubMed",
"id": "9884316",
"url": "https://glygen.org/publication/PubMed/9884316"
}
]
}
],
"pathway": [
{
"id": "hsa:1544",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1544",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-156581",
"name": "Methylation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156581",
"resource": "Reactome",
"description": "Methylation"
},
{
"id": "R-HSA-211957",
"name": "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211957",
"resource": "Reactome",
"description": "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2"
},
{
"id": "R-HSA-2142670",
"name": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670",
"resource": "Reactome",
"description": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"
},
{
"id": "R-HSA-2142816",
"name": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816",
"resource": "Reactome",
"description": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)"
},
{
"id": "R-HSA-5423646",
"name": "Aflatoxin activation and detoxification",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423646",
"resource": "Reactome",
"description": "Aflatoxin activation and detoxification"
},
{
"id": "R-HSA-9018681",
"name": "Biosynthesis of protectins",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681",
"resource": "Reactome",
"description": "Biosynthesis of protectins"
},
{
"id": "R-HSA-9027307",
"name": "Biosynthesis of maresin-like SPMs",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027307",
"resource": "Reactome",
"description": "Biosynthesis of maresin-like SPMs"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "P00186-1",
"protein_name": "Cytochrome P450 1A2",
"gene_name": "Cyp1a2",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MAFSQYISLAPELLLATAIFCLVFWMVRASRTQVPKGLKNPPGPWGLPFIGHMLTVGKNPHLSLTRLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSASSCYLEEHVSKEANHLVSKLQKAMAEVGHFEPVSQVVESVANVIGAMCFGKNFPRKSEEMLNIVNNSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKTFNDNFVLFLQKTVQEHYQDFNKNSIQDITSALFKHSENYKDNGGLIPEEKIVNIVNDIFGAGFDTVTTAITWSILLLVTWPNVQRKIHEELDTVVGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKERCIYINQWQVNHDEKQWKDPFVFRPERFLTNNNSAIDKTQSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLQHLEFSVPPGVKVDLTPNYGLTMKPGTCEHVQAWPRFSK",
"length": 513
},
"evidence": [
{
"id": "45917099",
"url": "http://www.informatics.jax.org/homology/45917099",
"database": "MGI"
},
{
"id": "P05177",
"url": "https://omabrowser.org/oma/group/P05177/",
"database": "OMA"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "P04799-1",
"protein_name": "Cytochrome P450 1A2",
"gene_name": "Cyp1a2",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MAFSQYISLAPELLLATAIFCLVFWVLRGTRTQVPKGLKSPPGPWGLPFIGHMLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLITNGKSMTFNPDSGPVWAARRRLAQDALKSFSIASDPTSVSSCYLEEHVSKEANHLISKFQKLMAEVGHFEPVNQVVESVANVIGAMCFGKNFPRKSEEMLNLVKSSKDFVENVTSGNAVDFFPVLRYLPNPALKRFKNFNDNFVLFLQKTVQEHYQDFNKNSIQDITGALFKHSENYKDNGGLIPQEKIVNIVNDIFGAGFETVTTAIFWSILLLVTEPKVQRKIHEELDTVIGRDRQPRLSDRPQLPYLEAFILEIYRYTSFVPFTIPHSTTRDTSLNGFHIPKECCIFINQWQVNHDEKQWKDPFVFRPERFLTNDNTAIDKTLSEKVMLFGLGKRRCIGEIPAKWEVFLFLAILLHQLEFTVPPGVKVDLTPSYGLTMKPRTCEHVQAWPRFSK",
"length": 513
},
"evidence": [
{
"id": "45917099",
"url": "http://www.informatics.jax.org/homology/45917099",
"database": "MGI"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Biological Process",
"total": 25,
"go_terms": [
{
"name": "estrogen metabolic process",
"id": "GO:0008210",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008210",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "monoterpenoid metabolic process",
"id": "GO:0016098",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016098",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "heterocycle metabolic process",
"id": "GO:0046483",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046483",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "omega-hydroxylase P450 pathway",
"id": "GO:0097267",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097267",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "cholesterol metabolic process",
"id": "GO:0008203",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008203",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "lung development",
"id": "GO:0030324",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030324",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "retinol metabolic process",
"id": "GO:0042572",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "xenobiotic metabolic process",
"id": "GO:0006805",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "post-embryonic development",
"id": "GO:0009791",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009791",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "xenobiotic catabolic process",
"id": "GO:0042178",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042178",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "hydrogen peroxide biosynthetic process",
"id": "GO:0050665",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050665",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "oxidative demethylation",
"id": "GO:0070989",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070989",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "regulation of gene expression",
"id": "GO:0010468",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "cellular response to cadmium ion",
"id": "GO:0071276",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071276",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "methylation",
"id": "GO:0032259",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "long-chain fatty acid biosynthetic process",
"id": "GO:0042759",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042759",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "epoxygenase P450 pathway",
"id": "GO:0019373",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "cellular respiration",
"id": "GO:0045333",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "steroid catabolic process",
"id": "GO:0006706",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006706",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "porphyrin-containing compound metabolic process",
"id": "GO:0006778",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006778",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "toxin biosynthetic process",
"id": "GO:0009403",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009403",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "alkaloid metabolic process",
"id": "GO:0009820",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009820",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "dibenzo-p-dioxin metabolic process",
"id": "GO:0018894",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018894",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "monocarboxylic acid metabolic process",
"id": "GO:0032787",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032787",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "aflatoxin metabolic process",
"id": "GO:0046222",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046222",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 13,
"go_terms": [
{
"name": "aromatase activity",
"id": "GO:0070330",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070330",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "estrogen 16-alpha-hydroxylase activity",
"id": "GO:0101020",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101020",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "iron ion binding",
"id": "GO:0005506",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "electron transfer activity",
"id": "GO:0009055",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "enzyme binding",
"id": "GO:0019899",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity",
"id": "GO:0016491",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "heme binding",
"id": "GO:0020037",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "demethylase activity",
"id": "GO:0032451",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032451",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"id": "GO:0016712",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "monooxygenase activity",
"id": "GO:0004497",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "caffeine oxidase activity",
"id": "GO:0034875",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034875",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "estrogen 2-hydroxylase activity",
"id": "GO:0101021",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101021",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "hydroperoxy icosatetraenoate dehydratase activity",
"id": "GO:0106256",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106256",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 2,
"go_terms": [
{
"name": "intracellular membrane-bounded organelle",
"id": "GO:0043231",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum membrane",
"id": "GO:0005789",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
"evidence": [
{
"database": "UniProtKB",
"id": "P05177",
"url": "https://www.uniprot.org/uniprot/P05177"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "17149",
"name": "",
"equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P11711-1",
"P05182-1",
"A0A8I6A0P6-1",
"P10633-1",
"P51538-1",
"P00176-1",
"P05178-1",
"P10610-1",
"P13107-1",
"P20812-1",
"P33272-1",
"P51870-1",
"P00185-1",
"Q64581-1",
"P05179-1",
"P51871-1",
"P04167-1",
"P04800-1",
"P05183-1",
"P10634-1",
"P11510-1",
"P12938-1",
"P12939-1",
"P15129-1",
"P15149-1",
"P20814-1",
"P33273-1",
"P51590-1",
"Q64583-1",
"Q64680-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24464-1",
"D4A820-1",
"A0A0G2K5K4-1",
"F1LT33-1",
"G3V9D2-1",
"Q9QXF7-1",
"A0A8I5ZZ08-1",
"P05181-1",
"A0A087X1C5-1",
"P08684-1",
"P20853-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q86W10-1",
"Q16678-1",
"P98187-1",
"P10632-1",
"P24462-1",
"Q9HB55-1",
"P13584-1",
"Q16696-1",
"Q9HCS2-1",
"P33260-1",
"Q02928-1",
"Q08477-1",
"Q9HBI6-1",
"P78329-1",
"P11712-1",
"P24903-1",
"P20815-1",
"Q6V0L0-1",
"P20852-1",
"O09158-1",
"O55071-1",
"Q64459-1",
"Q64481-1",
"O54749-1",
"P15392-1",
"Q8CIM7-1",
"P56654-1",
"P56655-1",
"P56656-1",
"P12791-1",
"P56593-1",
"O54750-1",
"Q91WL5-1",
"Q91X77-1",
"Q64458-1",
"P00186-1",
"P00184-1",
"Q6XVG2-1",
"Q9D816-1",
"P11714-1",
"P12790-1",
"P24457-1",
"Q9JMA7-1",
"P24456-1",
"Q64462-1",
"Q64464-1",
"Q05421-1",
"Q64429-1",
"D3YYZ0-1",
"D3Z2W7-1",
"B2RXZ2-1",
"Q9WV19-1",
"Q9DBX6-1",
"E9Q593-1",
"A2A974-1",
"A6H6J2-1",
"Q9EQW4-1",
"B2RXA7-1"
],
"evidence": [
{
"id": "17149",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17149"
}
]
},
{
"id": "37947",
"name": "",
"equation": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"D3ZKX9-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"Q96SQ9-1",
"Q9BYJ1-1",
"P00186-1",
"Q9DBX6-1",
"P00184-1",
"Q64429-1",
"Q9WV07-1"
],
"evidence": [
{
"id": "37947",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/37947"
}
]
},
{
"id": "39759",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q4V8D1-1",
"Q9QXF7-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P11712-1",
"Q7Z449-1",
"P00186-1",
"P00184-1",
"Q91WL5-1",
"Q9CX98-1",
"A2A974-1"
],
"evidence": [
{
"id": "39759",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39759"
}
]
},
{
"id": "39779",
"name": "",
"equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"P08683-1",
"P24470-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P10632-1",
"P11712-1",
"P00186-1",
"P00184-1",
"Q91WL5-1",
"E9Q5K4-1",
"A2A974-1"
],
"evidence": [
{
"id": "39779",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/39779"
}
]
},
{
"id": "42088",
"name": "",
"equation": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"Q9QXF7-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "42088",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/42088"
}
]
},
{
"id": "42092",
"name": "",
"equation": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P10635-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P20815-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "42092",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/42092"
}
]
},
{
"id": "47208",
"name": "",
"equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P11511-1",
"P20813-1",
"P24462-1",
"P11712-1",
"P20815-1",
"P28649-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "47208",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/47208"
}
]
},
{
"id": "47212",
"name": "",
"equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P11712-1",
"P20813-1",
"P24462-1",
"P20815-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "47212",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/47212"
}
]
},
{
"id": "47280",
"name": "",
"equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P20815-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "47280",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/47280"
}
]
},
{
"id": "47292",
"name": "",
"equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08684-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"P24462-1",
"P20815-1",
"P00186-1",
"P00184-1",
"Q64429-1"
],
"evidence": [
{
"id": "47292",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/47292"
}
]
},
{
"id": "48632",
"name": "",
"equation": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"Q96SQ9-1",
"P00186-1",
"P00184-1",
"Q9DBX6-1",
"Q64429-1"
],
"evidence": [
{
"id": "48632",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/48632"
}
]
},
{
"id": "48636",
"name": "",
"equation": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P49430-1",
"D3ZKX9-1",
"Q62969-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"Q96SQ9-1",
"Q9BYJ1-1",
"Q16647-1",
"P24557-1",
"P00186-1",
"P00184-1",
"Q9DBX6-1",
"Q64429-1",
"Q9WV07-1",
"O35074-1",
"P36423-1"
],
"evidence": [
{
"id": "48636",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/48636"
}
]
},
{
"id": "48716",
"name": "",
"equation": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"D3ZKX9-1",
"P04798-1",
"P05177-1",
"Q16678-1",
"Q96SQ9-1",
"Q9BYJ1-1",
"P00186-1",
"P00184-1",
"Q9DBX6-1",
"Q64429-1",
"Q9WV07-1"
],
"evidence": [
{
"id": "48716",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/48716"
}
]
},
{
"id": "49856",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P10635-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P10632-1",
"P11712-1",
"Q86W10-1",
"P00186-1",
"P00184-1",
"P56657-1"
],
"evidence": [
{
"id": "49856",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49856"
}
]
},
{
"id": "49860",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"Q64678-1",
"P08683-1",
"P24470-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"Q16678-1",
"P10632-1",
"P11712-1",
"P00186-1",
"P00184-1",
"Q64429-1",
"P56657-1"
],
"evidence": [
{
"id": "49860",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/49860"
}
]
},
{
"id": "50256",
"name": "",
"equation": "cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 25-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"P10635-1",
"P08684-1",
"P05177-1",
"P11712-1",
"P00186-1"
],
"evidence": [
{
"id": "50256",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/50256"
}
]
},
{
"id": "52120",
"name": "",
"equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00185-1",
"P04799-1",
"P10635-1",
"P08684-1",
"P51589-1",
"P04798-1",
"P05177-1",
"P33261-1",
"P10632-1",
"P00186-1",
"P00184-1"
],
"evidence": [
{
"id": "52120",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52120"
}
]
},
{
"id": "52284",
"name": "",
"equation": "(9Z,12Z)-octadecadienoate + O2 + reduced [NADPH--hemoprotein reductase] = 11-hydroxy-(9Z,12Z)-octadecadienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"P08684-1",
"P05177-1",
"P00186-1"
],
"evidence": [
{
"id": "52284",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52284"
}
]
},
{
"id": "52292",
"name": "",
"equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04799-1",
"P08684-1",
"P05177-1",
"P11712-1",
"P00186-1"
],
"evidence": [
{
"id": "52292",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/52292"
}
]
},
{
"id": "R-HSA-156526",
"name": "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO",
"equation": "",
"summary": "Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFXBO). This conversion is carried out by at least four P450s; 1A2, 3A4, 3A5 and 2A13. CYP3A4 mainly produces the exo form whereas CYP1A2 produces a racemic mixture of exo and endo forms (Gallagher et al. 1996, He et al. 2006).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-5423605"
],
"output_participant_list": [
"R-ALL-159211"
],
"enzyme_list": [
"P20815-1",
"Q16696-1",
"P05177-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-156526",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-156526"
}
]
},
{
"id": "R-HSA-2161795",
"name": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)",
"equation": "",
"summary": "Cytochrome P450s 1A1 (CYP1A1), 1A2 (CYP1A2), and 1B1 (CYP1B1) convert arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids (16-, 17-, and 18-HETEs) (Choudhary et al. 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q16678-1",
"P04798-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161795",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161795"
}
]
},
{
"id": "R-HSA-2161814",
"name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-2142836"
],
"enzyme_list": [
"P33261-1",
"Q16678-1",
"Q7Z449-1",
"P04798-1",
"P10632-1",
"P11712-1",
"Q02928-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161814",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161814"
}
]
},
{
"id": "R-HSA-2161890",
"name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-2142739"
],
"enzyme_list": [
"P51589-1",
"Q16678-1",
"P04798-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161890",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161890"
}
]
},
{
"id": "R-HSA-2161899",
"name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P33261-1",
"P51589-1",
"Q16678-1",
"P04798-1",
"P10632-1",
"P11712-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161899",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161899"
}
]
},
{
"id": "R-HSA-2161940",
"name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)",
"equation": "",
"summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). The CYPs and their references are as follows: CYP4A11 (Gainer et al. 2005, Powell 1998); CYP4F2 (Powell et al. 1998, Kikuta et al. 2002); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).",
"cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-2142780"
],
"enzyme_list": [
"Q16678-1",
"Q7Z449-1",
"P04798-1",
"P78329-1",
"Q02928-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-2161940",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161940"
}
]
},
{
"id": "R-HSA-5423672",
"name": "CYP1A2, 3A4 oxidise AFB1 to AFNBO",
"equation": "",
"summary": "Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFNBO). CYP3A4 and CYP1A2 can also produce aflatoxin B1-endo-8,9-epoxide (Raney et al. 1992, Ueng et al. 1995).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-5423663"
],
"enzyme_list": [
"P05177-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-5423672",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423672"
}
]
},
{
"id": "R-HSA-5423678",
"name": "CYP1A2 hydroxylates AFB1 to AFM1",
"equation": "",
"summary": "Aflatoxin B1 (AFB1) undergoes extensive oxidation, which is catalysed by cytochrome P450s. In addition to formation of the 8,9-oxide, oxidation by CYP1A2 yields a stable metabolite, aflatoxin M1 (AFM1), that is excreted in milk and urine (Ueng et al. 1995). AFM1 is less carcinogenic or mutagenic than AFB1, but is equally toxic.",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-5423678",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5423678"
}
]
},
{
"id": "R-HSA-76373",
"name": "N-hydroxylation of 4-aminobiphenyl",
"equation": "",
"summary": "Heterocyclic and aromatic amines require metabolic activation to convert them to genotoxic metabolites.The initial step is N-hydroxylation and cytochrome P450 1A2 can carry out the catalysis.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-47687"
],
"output_participant_list": [
"R-ALL-34889"
],
"enzyme_list": [
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-76373",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76373"
}
]
},
{
"id": "R-HSA-76386",
"name": "CYP1A2 S-demethylates 6MMP",
"equation": "",
"summary": "At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of '6-Methylmercaptopurine', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of '6-Mercaptopurine', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 1A2 '.
",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-76384"
],
"output_participant_list": [
"R-ALL-143501",
"R-ALL-33153"
],
"enzyme_list": [
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-76386",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76386"
}
]
},
{
"id": "R-HSA-76426",
"name": "N-atom dealkylation of caffeine",
"equation": "",
"summary": "Caffeine is one of the world's most frequently consumed xenobiotic. The major source of caffeine comes from tea and coffee. Caffeine is extensively metabolized in humans with at least 17 metabolites formed in its biotransformation. CYP1A2 is a prominent enzyme in the formation of an important metabolite of caffeine (paraxanthine) by N3-demethylation.",
"cellular_location": "smooth endoplasmic reticulum",
"input_participant_list": [
"R-ALL-40727"
],
"output_participant_list": [
"R-ALL-76424"
],
"enzyme_list": [
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-76426",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76426"
}
]
},
{
"id": "R-HSA-9027043",
"name": "CYPs hydroxylate DHA to 14(R)-HDHA",
"equation": "",
"summary": "Using human leukocytes and platelets, Hong et al. found that incubating docosahexaenoic acid (DHA) with a mixture of human cytochrome P450 enzymes (CYP1A2, 2C8, 2C9, 2D6, 2E1 and 3A4) formed 14(R)-hydroxy-docsosahexaenoic acid (14(R)-HDHA), the precursor to maresin-like mediator 2 (MaR-L2) (Hong et al. 2014). There is no data to indicate which one or ones of these CYPs mediate this event under physiological conditions. CYP inhibition diminishes the formation of 14(R)-HDHA, confirming CYP determines 14(R)-hydroxylation (Hong et al. 2014). The CYP mixture also formed 22-hydroxy-docosahexaenoic acid (22-HDHA) by \u03c9-oxidation (not shown here). Although the CYP mixture also catalysed the formation of 14(S)-HDHA, the amount formed is minor compared to that formed by 12-lipoxygenase (Hong et al. 2014).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9024011"
],
"output_participant_list": [],
"enzyme_list": [
"P05181-1",
"P10635-1",
"P10632-1",
"P11712-1",
"P05177-1",
"P08684-1"
],
"evidence": [
{
"id": "R-HSA-9027043",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027043"
}
]
},
{
"id": "R-HSA-9037761",
"name": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1",
"equation": "",
"summary": "Protectin D1, identified as (N)PD1 (N signifies neuroprotectin when produced in neural tissues), is a natural product derived from docosahexaenoic acid (DHA) through the actions of 15 lipoxygenase followed by enzymatic hydrolysis by an unidentified hydrolase. (N)PD1 is one of the specialized proresolving mediators (SPMs) that show potent anti inflammatory and pro resolving actions (Molfino et al. 2017, Balas & Durand 2016). (N)PD1 has been the subject of many pharmacological studies for the development of potential new anti inflammatory drugs. The 22 hydroxylated metabolite of (N)PD1 (here signified as 22 OH (N)PD1) has been shown to exhibit potent pro resolving actions by inhibiting PMN chemotaxis in vivo with mice and in vitro with human cells and decreases pro inflammatory mediator levels in inflammatory exudates. These observations were comparable to those of its precursor (N)PD1 (Tungen et al. 2014). 22 OH (N)PD1 is most likely formed by the action of CYP1 monooxygenases, just like for some other SPMs (Divanovic et al. 2013).",
"cellular_location": "cytosol, endoplasmic reticulum membrane",
"input_participant_list": [
"R-ALL-9024886"
],
"output_participant_list": [
"R-ALL-9037755"
],
"enzyme_list": [
"P04798-1",
"P05177-1"
],
"evidence": [
{
"id": "R-HSA-9037761",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9037761"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-143501",
"participant_name": "CH2O [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "C00067",
"database": "COMPOUND",
"url": ""
},
{
"id": "16842",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0001426",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8143624",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0001426",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C00067",
"database": "COMPOUND",
"url": ""
},
{
"id": "8143624",
"database": "PubChem Substance",
"url": ""
},
{
"id": "16842",
"database": "ChEBI",
"url": ""
},
{
"id": "C00067",
"database": "COMPOUND",
"url": ""
},
{
"id": "16842",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0001426",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8143624",
"database": "PubChem Substance",
"url": ""
},
{
"id": "16842",
"database": "ChEBI",
"url": ""
},
{
"id": "8143624",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C00067",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0001426",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C00067",
"database": "COMPOUND",
"url": ""
},
{
"id": "16842",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0001426",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8143624",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C00067",
"database": "COMPOUND",
"url": ""
},
{
"id": "16842",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0001426",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8143624",
"database": "PubChem Substance",
"url": ""
}
]
},
{
"participant_id": "R-ALL-159211",
"participant_name": "AFXBO [cytosol]",
"crossref": [
{
"id": "30725",
"database": "ChEBI",
"url": ""
},
{
"id": "000006017718",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006558",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "HMDB0006558",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "30725",
"database": "ChEBI",
"url": ""
},
{
"id": "000006017718",
"database": "ZINC",
"url": ""
},
{
"id": "30725",
"database": "ChEBI",
"url": ""
},
{
"id": "000006017718",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006558",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000006017718",
"database": "ZINC",
"url": ""
},
{
"id": "30725",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0006558",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "30725",
"database": "ChEBI",
"url": ""
},
{
"id": "000006017718",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006558",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "30725",
"database": "ChEBI",
"url": ""
},
{
"id": "000006017718",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006558",
"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-ALL-2142739",
"participant_name": "5,6-EET [cytosol]",
"crossref": [
{
"id": "34450",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0002190",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "6304",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000004655402",
"database": "ZINC",
"url": ""
},
{
"id": "000012495586",
"database": "ZINC",
"url": ""
},
{
"id": "000012495581",
"database": "ZINC",
"url": ""
},
{
"id": "000004655403",
"database": "ZINC",
"url": ""
},
{
"id": "C14768",
"database": "COMPOUND",
"url": ""
},
{
"id": "34450",
"database": "ChEBI",
"url": ""
},
{
"id": "000012495586",
"database": "ZINC",
"url": ""
},
{
"id": "000004655403",
"database": "ZINC",
"url": ""
},
{
"id": "6304",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "C14768",
"database": "COMPOUND",
"url": ""
},
{
"id": "000004655402",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0002190",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000012495581",
"database": "ZINC",
"url": ""
},
{
"id": "34450",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0002190",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "6304",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000004655402",
"database": "ZINC",
"url": ""
},
{
"id": "000012495586",
"database": "ZINC",
"url": ""
},
{
"id": "000012495581",
"database": "ZINC",
"url": ""
},
{
"id": "000004655403",
"database": "ZINC",
"url": ""
},
{
"id": "C14768",
"database": "COMPOUND",
"url": ""
},
{
"id": "34450",
"database": "ChEBI",
"url": ""
},
{
"id": "000012495586",
"database": "ZINC",
"url": ""
},
{
"id": "000004655403",
"database": "ZINC",
"url": ""
},
{
"id": "6304",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "C14768",
"database": "COMPOUND",
"url": ""
},
{
"id": "000004655402",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0002190",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000012495581",
"database": "ZINC",
"url": ""
},
{
"id": "34450",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0002190",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "6304",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000004655402",
"database": "ZINC",
"url": ""
},
{
"id": "000012495586",
"database": "ZINC",
"url": ""
},
{
"id": "000012495581",
"database": "ZINC",
"url": ""
},
{
"id": "000004655403",
"database": "ZINC",
"url": ""
},
{
"id": "C14768",
"database": "COMPOUND",
"url": ""
},
{
"id": "34450",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0002190",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "6304",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000004655402",
"database": "ZINC",
"url": ""
},
{
"id": "000012495586",
"database": "ZINC",
"url": ""
},
{
"id": "000012495581",
"database": "ZINC",
"url": ""
},
{
"id": "000004655403",
"database": "ZINC",
"url": ""
},
{
"id": "C14768",
"database": "COMPOUND",
"url": ""
}
]
},
{
"participant_id": "R-ALL-2142780",
"participant_name": "20-HETE [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "34306",
"database": "ChEBI",
"url": ""
},
{
"id": "4103",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "HMDB0005998",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000004655386",
"database": "ZINC",
"url": ""
},
{
"id": "C14748",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0005998",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C14748",
"database": "COMPOUND",
"url": ""
},
{
"id": "34306",
"database": "ChEBI",
"url": ""
},
{
"id": "4103",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000004655386",
"database": "ZINC",
"url": ""
},
{
"id": "34306",
"database": "ChEBI",
"url": ""
},
{
"id": "4103",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "HMDB0005998",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000004655386",
"database": "ZINC",
"url": ""
},
{
"id": "C14748",
"database": "COMPOUND",
"url": ""
},
{
"id": "4103",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000004655386",
"database": "ZINC",
"url": ""
},
{
"id": "C14748",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0005998",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "34306",
"database": "ChEBI",
"url": ""
},
{
"id": "34306",
"database": "ChEBI",
"url": ""
},
{
"id": "4103",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "HMDB0005998",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000004655386",
"database": "ZINC",
"url": ""
},
{
"id": "C14748",
"database": "COMPOUND",
"url": ""
}
]
},
{
"participant_id": "R-ALL-2142836",
"participant_name": "19-HETE [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "63998",
"database": "ChEBI",
"url": ""
},
{
"id": "000004655388",
"database": "ZINC",
"url": ""
},
{
"id": "000004655387",
"database": "ZINC",
"url": ""
},
{
"id": "000004655388",
"database": "ZINC",
"url": ""
},
{
"id": "000004655387",
"database": "ZINC",
"url": ""
},
{
"id": "63998",
"database": "ChEBI",
"url": ""
},
{
"id": "63998",
"database": "ChEBI",
"url": ""
},
{
"id": "000004655388",
"database": "ZINC",
"url": ""
},
{
"id": "000004655387",
"database": "ZINC",
"url": ""
},
{
"id": "000004655388",
"database": "ZINC",
"url": ""
},
{
"id": "63998",
"database": "ChEBI",
"url": ""
},
{
"id": "000004655387",
"database": "ZINC",
"url": ""
},
{
"id": "63998",
"database": "ChEBI",
"url": ""
},
{
"id": "000004655388",
"database": "ZINC",
"url": ""
},
{
"id": "000004655387",
"database": "ZINC",
"url": ""
},
{
"id": "63998",
"database": "ChEBI",
"url": ""
},
{
"id": "000004655388",
"database": "ZINC",
"url": ""
},
{
"id": "000004655387",
"database": "ZINC",
"url": ""
}
]
},
{
"participant_id": "R-ALL-33153",
"participant_name": "6MP [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "C02380",
"database": "COMPOUND",
"url": ""
},
{
"id": "2208",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0015167",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000004658290",
"database": "ZINC",
"url": ""
},
{
"id": "8148223",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C02380",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0015167",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8148223",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000004658290",
"database": "ZINC",
"url": ""
},
{
"id": "2208",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0015167",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C02380",
"database": "COMPOUND",
"url": ""
},
{
"id": "8148223",
"database": "PubChem Substance",
"url": ""
},
{
"id": "2208",
"database": "ChEBI",
"url": ""
},
{
"id": "000004658290",
"database": "ZINC",
"url": ""
},
{
"id": "C02380",
"database": "COMPOUND",
"url": ""
},
{
"id": "2208",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0015167",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000004658290",
"database": "ZINC",
"url": ""
},
{
"id": "8148223",
"database": "PubChem Substance",
"url": ""
}
]
},
{
"participant_id": "R-ALL-34889",
"participant_name": "NHABP [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "C03622",
"database": "COMPOUND",
"url": ""
},
{
"id": "16580",
"database": "ChEBI",
"url": ""
},
{
"id": "8143500",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000000901785",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0062723",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000000901785",
"database": "ZINC",
"url": ""
},
{
"id": "16580",
"database": "ChEBI",
"url": ""
},
{
"id": "C03622",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0062723",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8143500",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C03622",
"database": "COMPOUND",
"url": ""
},
{
"id": "8143500",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0062723",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000000901785",
"database": "ZINC",
"url": ""
},
{
"id": "16580",
"database": "ChEBI",
"url": ""
},
{
"id": "C03622",
"database": "COMPOUND",
"url": ""
},
{
"id": "16580",
"database": "ChEBI",
"url": ""
},
{
"id": "8143500",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000000901785",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0062723",
"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-ALL-40727",
"participant_name": "CAF [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "HMDB0001847",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8144467",
"database": "PubChem Substance",
"url": ""
},
{
"id": "27732",
"database": "ChEBI",
"url": ""
},
{
"id": "C07481",
"database": "COMPOUND",
"url": ""
},
{
"id": "407",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000000001084",
"database": "ZINC",
"url": ""
},
{
"id": "C07481",
"database": "COMPOUND",
"url": ""
},
{
"id": "27732",
"database": "ChEBI",
"url": ""
},
{
"id": "407",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "HMDB0001847",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000000001084",
"database": "ZINC",
"url": ""
},
{
"id": "8144467",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C07481",
"database": "COMPOUND",
"url": ""
},
{
"id": "27732",
"database": "ChEBI",
"url": ""
},
{
"id": "407",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "HMDB0001847",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000000001084",
"database": "ZINC",
"url": ""
},
{
"id": "8144467",
"database": "PubChem Substance",
"url": ""
},
{
"id": "407",
"database": "Guide to Pharmacology - Ligands",
"url": ""
},
{
"id": "000000001084",
"database": "ZINC",
"url": ""
},
{
"id": "C07481",
"database": "COMPOUND",
"url": ""
},
{
"id": "8144467",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0001847",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "27732",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-ALL-47687",
"participant_name": "ABPH [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "8148233",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0013195",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C10998",
"database": "COMPOUND",
"url": ""
},
{
"id": "1784",
"database": "ChEBI",
"url": ""
},
{
"id": "000038338719",
"database": "ZINC",
"url": ""
},
{
"id": "C10998",
"database": "COMPOUND",
"url": ""
},
{
"id": "1784",
"database": "ChEBI",
"url": ""
},
{
"id": "8148233",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000038338719",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0013195",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C10998",
"database": "COMPOUND",
"url": ""
},
{
"id": "1784",
"database": "ChEBI",
"url": ""
},
{
"id": "8148233",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000038338719",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0013195",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000038338719",
"database": "ZINC",
"url": ""
},
{
"id": "1784",
"database": "ChEBI",
"url": ""
},
{
"id": "C10998",
"database": "COMPOUND",
"url": ""
},
{
"id": "8148233",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0013195",
"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-ALL-5423605",
"participant_name": "AFB1 [cytosol]",
"crossref": [
{
"id": "C06800",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0006552",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000000402671",
"database": "ZINC",
"url": ""
},
{
"id": "2504",
"database": "ChEBI",
"url": ""
},
{
"id": "8147046",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C06800",
"database": "COMPOUND",
"url": ""
},
{
"id": "2504",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0006552",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8147046",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000000402671",
"database": "ZINC",
"url": ""
},
{
"id": "2504",
"database": "ChEBI",
"url": ""
},
{
"id": "8147046",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C06800",
"database": "COMPOUND",
"url": ""
},
{
"id": "000000402671",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006552",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C06800",
"database": "COMPOUND",
"url": ""
},
{
"id": "2504",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0006552",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8147046",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000000402671",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006552",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000000402671",
"database": "ZINC",
"url": ""
},
{
"id": "C06800",
"database": "COMPOUND",
"url": ""
},
{
"id": "8147046",
"database": "PubChem Substance",
"url": ""
},
{
"id": "2504",
"database": "ChEBI",
"url": ""
},
{
"id": "000000402671",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0006552",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C06800",
"database": "COMPOUND",
"url": ""
},
{
"id": "8147046",
"database": "PubChem Substance",
"url": ""
},
{
"id": "2504",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-ALL-5423663",
"participant_name": "AFNBO [cytosol]",
"crossref": [
{
"id": "78586",
"database": "ChEBI",
"url": ""
},
{
"id": "000070647042",
"database": "ZINC",
"url": ""
},
{
"id": "78586",
"database": "ChEBI",
"url": ""
},
{
"id": "000070647042",
"database": "ZINC",
"url": ""
},
{
"id": "78586",
"database": "ChEBI",
"url": ""
},
{
"id": "000070647042",
"database": "ZINC",
"url": ""
},
{
"id": "78586",
"database": "ChEBI",
"url": ""
},
{
"id": "000070647042",
"database": "ZINC",
"url": ""
}
]
},
{
"participant_id": "R-ALL-76384",
"participant_name": "6MMP [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "28279",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0060412",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000018113502",
"database": "ZINC",
"url": ""
},
{
"id": "8144367",
"database": "PubChem Substance",
"url": ""
},
{
"id": "28279",
"database": "ChEBI",
"url": ""
},
{
"id": "8144367",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0060412",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000018113502",
"database": "ZINC",
"url": ""
},
{
"id": "28279",
"database": "ChEBI",
"url": ""
},
{
"id": "8144367",
"database": "PubChem Substance",
"url": ""
},
{
"id": "HMDB0060412",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "000018113502",
"database": "ZINC",
"url": ""
},
{
"id": "8144367",
"database": "PubChem Substance",
"url": ""
},
{
"id": "000018113502",
"database": "ZINC",
"url": ""
},
{
"id": "28279",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0060412",
"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-ALL-76424",
"participant_name": "Paraxanthine [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "C13747",
"database": "COMPOUND",
"url": ""
},
{
"id": "25858",
"database": "ChEBI",
"url": ""
},
{
"id": "000000120234",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0001860",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8146787",
"database": "PubChem Substance",
"url": ""
},
{
"id": "25858",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0001860",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8146787",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C13747",
"database": "COMPOUND",
"url": ""
},
{
"id": "000000120234",
"database": "ZINC",
"url": ""
},
{
"id": "000000120234",
"database": "ZINC",
"url": ""
},
{
"id": "8146787",
"database": "PubChem Substance",
"url": ""
},
{
"id": "C13747",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0001860",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "25858",
"database": "ChEBI",
"url": ""
},
{
"id": "C13747",
"database": "COMPOUND",
"url": ""
},
{
"id": "25858",
"database": "ChEBI",
"url": ""
},
{
"id": "000000120234",
"database": "ZINC",
"url": ""
},
{
"id": "HMDB0001860",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "8146787",
"database": "PubChem Substance",
"url": ""
}
]
},
{
"participant_id": "R-ALL-9024011",
"participant_name": "DHA [cytosol]",
"crossref": [
{
"id": "000004474564",
"database": "ZINC",
"url": ""
},
{
"id": "77016",
"database": "ChEBI",
"url": ""
},
{
"id": "77016",
"database": "ChEBI",
"url": ""
},
{
"id": "000004474564",
"database": "ZINC",
"url": ""
},
{
"id": "77016",
"database": "ChEBI",
"url": ""
},
{
"id": "000004474564",
"database": "ZINC",
"url": ""
},
{
"id": "77016",
"database": "ChEBI",
"url": ""
},
{
"id": "000004474564",
"database": "ZINC",
"url": ""
},
{
"id": "77016",
"database": "ChEBI",
"url": ""
},
{
"id": "000004474564",
"database": "ZINC",
"url": ""
},
{
"id": "000004474564",
"database": "ZINC",
"url": ""
},
{
"id": "77016",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-ALL-9024886",
"participant_name": "(N)PD1 [cytosol]",
"crossref": [
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "138655",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0003689",
"database": "HMDB Metabolite",
"url": ""
}
]
},
{
"participant_id": "R-ALL-9037755",
"participant_name": "22-OH-(N)PD1 [cytosol]",
"crossref": [
{
"id": "140243",
"database": "ChEBI",
"url": ""
},
{
"id": "140243",
"database": "ChEBI",
"url": ""
},
{
"id": "140243",
"database": "ChEBI",
"url": ""
},
{
"id": "140243",
"database": "ChEBI",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "A0A087X1C5",
"gene_name": "CYP2D7",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "A0A087X1C5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087X1C5"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "A0A087X1C5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087X1C5"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "A0A087X1C5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087X1C5"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K5K4",
"gene_name": "Cyp3a62",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "A0A0G2K5K4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K5K4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZZ08",
"gene_name": "LOC103691092",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "A0A8I5ZZ08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZZ08"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZZ08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZZ08"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A0P6",
"gene_name": "Cyp3a73",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "A0A8I6A0P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A0P6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "A0A8I6A0P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A0P6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A0P6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A0P6"
}
]
}
]
},
{
"uniprot_ac": "A2A974",
"gene_name": "Cyp4a12b",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "A2A974",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2A974"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "A2A974",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2A974"
}
]
}
]
},
{
"uniprot_ac": "A6H6J2",
"gene_name": "Cyp2b13",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "A6H6J2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6H6J2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "A6H6J2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6H6J2"
}
]
}
]
},
{
"uniprot_ac": "B2RXA7",
"gene_name": "Cyp26c1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "B2RXA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2RXA7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "B2RXA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2RXA7"
}
]
}
]
},
{
"uniprot_ac": "B2RXZ2",
"gene_name": "Cyp2a22",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "B2RXZ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2RXZ2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "B2RXZ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2RXZ2"
}
]
}
]
},
{
"uniprot_ac": "D3YYZ0",
"gene_name": "Cyp3a57",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "D3YYZ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3YYZ0"
}
]
}
]
},
{
"uniprot_ac": "D3Z2W7",
"gene_name": "Cyp3a59",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "D3Z2W7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z2W7"
}
]
}
]
},
{
"uniprot_ac": "D3ZKX9",
"gene_name": "Aloxe3",
"activity": [
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "D3ZKX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZKX9"
}
]
},
{
"ec_number": "5.4.4.7",
"activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.",
"evidence": [
{
"id": "D3ZKX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZKX9"
}
]
}
]
},
{
"uniprot_ac": "D4A820",
"gene_name": "Cyp2s1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "D4A820",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A820"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "D4A820",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A820"
}
]
}
]
},
{
"uniprot_ac": "E9Q593",
"gene_name": "Cyp2b23",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "E9Q593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q593"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "E9Q593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q593"
}
]
}
]
},
{
"uniprot_ac": "E9Q5K4",
"gene_name": "Cyp2c23",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "E9Q5K4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q5K4"
}
]
}
]
},
{
"uniprot_ac": "F1LT33",
"gene_name": "Cyp2b14",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "F1LT33",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LT33"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "F1LT33",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LT33"
}
]
}
]
},
{
"uniprot_ac": "G3V9D2",
"gene_name": "Cyp2b21",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "G3V9D2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V9D2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "G3V9D2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V9D2"
}
]
}
]
},
{
"uniprot_ac": "O09158",
"gene_name": "Cyp3a25",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "O09158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09158"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "O09158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09158"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "O09158",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09158"
}
]
}
]
},
{
"uniprot_ac": "O35074",
"gene_name": "Ptgis",
"activity": [
{
"ec_number": "5.3.99.4",
"activity": "prostaglandin H2 = prostaglandin I2.",
"evidence": [
{
"id": "O35074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35074"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "O35074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35074"
}
]
},
{
"ec_number": "5.3.99.4",
"activity": "",
"evidence": [
{
"id": "O35074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35074"
}
]
}
]
},
{
"uniprot_ac": "O54749",
"gene_name": "Cyp2j5",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "O54749",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54749"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "O54749",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54749"
}
]
}
]
},
{
"uniprot_ac": "O54750",
"gene_name": "Cyp2j6",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "O54750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54750"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "O54750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54750"
}
]
}
]
},
{
"uniprot_ac": "O55071",
"gene_name": "Cyp2b19",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "O55071",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55071"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "O55071",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55071"
}
]
}
]
},
{
"uniprot_ac": "P00176",
"gene_name": "Cyp2b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P00176",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00176"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00176",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00176"
}
]
}
]
},
{
"uniprot_ac": "P00184",
"gene_name": "Cyp1a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P00184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00184"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P00184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00184"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00184"
}
]
}
]
},
{
"uniprot_ac": "P00185",
"gene_name": "Cyp1a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P00185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00185"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P00185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00185"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00185"
}
]
}
]
},
{
"uniprot_ac": "P00186",
"gene_name": "Cyp1a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P00186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00186"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P00186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00186"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P00186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00186"
}
]
}
]
},
{
"uniprot_ac": "P04167",
"gene_name": "Cyp2b2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04167"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04167",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04167"
}
]
}
]
},
{
"uniprot_ac": "P04798",
"gene_name": "CYP1A1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04798"
}
]
}
]
},
{
"uniprot_ac": "P04799",
"gene_name": "Cyp1a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P04799",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04799"
}
]
}
]
},
{
"uniprot_ac": "P04800",
"gene_name": "Cyp3a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P04800",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04800"
}
]
}
]
},
{
"uniprot_ac": "P05177",
"gene_name": "CYP1A2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05177"
}
]
}
]
},
{
"uniprot_ac": "P05178",
"gene_name": "Cyp2c6",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05178"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05178"
}
]
}
]
},
{
"uniprot_ac": "P05179",
"gene_name": "Cyp2c7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05179",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05179"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05179",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05179"
}
]
}
]
},
{
"uniprot_ac": "P05181",
"gene_name": "CYP2E1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "P05181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05181"
}
]
}
]
},
{
"uniprot_ac": "P05182",
"gene_name": "Cyp2e1",
"activity": [
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05182"
}
]
}
]
},
{
"uniprot_ac": "P05183",
"gene_name": "Cyp3a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P05183",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05183"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P05183",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05183"
}
]
}
]
},
{
"uniprot_ac": "P08683",
"gene_name": "Cyp2c11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08683"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P08683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08683"
}
]
}
]
},
{
"uniprot_ac": "P08684",
"gene_name": "CYP3A4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.55",
"activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.56",
"activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P08684",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08684"
}
]
}
]
},
{
"uniprot_ac": "P10610",
"gene_name": "Cyp2g1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10610",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10610"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10610",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10610"
}
]
}
]
},
{
"uniprot_ac": "P10632",
"gene_name": "CYP2C8",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10632",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10632"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10632",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10632"
}
]
}
]
},
{
"uniprot_ac": "P10633",
"gene_name": "Cyp2d1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10633"
}
]
}
]
},
{
"uniprot_ac": "P10634",
"gene_name": "Cyp2d26",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P10634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10634"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P10634",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10634"
}
]
}
]
},
{
"uniprot_ac": "P10635",
"gene_name": "CYP2D6",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P10635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10635"
}
]
}
]
},
{
"uniprot_ac": "P11510",
"gene_name": "Cyp2c12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11510"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11510"
}
]
}
]
},
{
"uniprot_ac": "P11511",
"gene_name": "CYP19A1",
"activity": [
{
"ec_number": "1.14.14.14",
"activity": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11511",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11511"
}
]
},
{
"ec_number": "1.14.14.14",
"activity": "",
"evidence": [
{
"id": "P11511",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11511"
}
]
}
]
},
{
"uniprot_ac": "P11711",
"gene_name": "Cyp2a1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11711"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11711",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11711"
}
]
}
]
},
{
"uniprot_ac": "P11712",
"gene_name": "CYP2C9",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.51",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.52",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.53",
"activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11712",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11712"
}
]
}
]
},
{
"uniprot_ac": "P11714",
"gene_name": "Cyp2d9",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P11714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11714"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P11714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11714"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P11714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11714"
}
]
}
]
},
{
"uniprot_ac": "P12790",
"gene_name": "Cyp2b9",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P12790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12790"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P12790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12790"
}
]
}
]
},
{
"uniprot_ac": "P12791",
"gene_name": "Cyp2b10",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P12791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12791"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P12791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12791"
}
]
}
]
},
{
"uniprot_ac": "P12938",
"gene_name": "Cyp2d3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P12938",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12938"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P12938",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12938"
}
]
}
]
},
{
"uniprot_ac": "P12939",
"gene_name": "Cyp2d10",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P12939",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12939"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P12939",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12939"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P12939",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12939"
}
]
}
]
},
{
"uniprot_ac": "P13107",
"gene_name": "Cyp2b3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P13107",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13107"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P13107",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13107"
}
]
}
]
},
{
"uniprot_ac": "P13584",
"gene_name": "CYP4B1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P13584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13584"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P13584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13584"
}
]
}
]
},
{
"uniprot_ac": "P15129",
"gene_name": "Cyp4b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P15129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15129"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P15129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15129"
}
]
}
]
},
{
"uniprot_ac": "P15149",
"gene_name": "Cyp2a2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P15149",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15149"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P15149",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15149"
}
]
}
]
},
{
"uniprot_ac": "P15392",
"gene_name": "Cyp2a4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P15392",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15392"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P15392",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15392"
}
]
}
]
},
{
"uniprot_ac": "P20812",
"gene_name": "Cyp2a3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20812",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20812"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20812",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20812"
}
]
}
]
},
{
"uniprot_ac": "P20813",
"gene_name": "CYP2B6",
"activity": [
{
"ec_number": "1.14.13.-",
"activity": "",
"evidence": [
{
"id": "P20813",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20813"
}
]
}
]
},
{
"uniprot_ac": "P20814",
"gene_name": "Cyp2c13",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20814",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20814"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20814",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20814"
}
]
}
]
},
{
"uniprot_ac": "P20815",
"gene_name": "CYP3A5",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20815",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20815"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20815",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20815"
}
]
}
]
},
{
"uniprot_ac": "P20852",
"gene_name": "Cyp2a5",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20852",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20852"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20852",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20852"
}
]
}
]
},
{
"uniprot_ac": "P20853",
"gene_name": "CYP2A7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P20853",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20853"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P20853",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20853"
}
]
}
]
},
{
"uniprot_ac": "P24456",
"gene_name": "Cyp2d10",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P24456",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24456"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24456",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24456"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24456",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24456"
}
]
}
]
},
{
"uniprot_ac": "P24457",
"gene_name": "Cyp2d11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24457",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24457"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24457",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24457"
}
]
}
]
},
{
"uniprot_ac": "P24462",
"gene_name": "CYP3A7",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24462"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24462"
}
]
}
]
},
{
"uniprot_ac": "P24464",
"gene_name": "Cyp4a12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24464"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24464"
}
]
}
]
},
{
"uniprot_ac": "P24470",
"gene_name": "Cyp2c23",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P24470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24470"
}
]
}
]
},
{
"uniprot_ac": "P24557",
"gene_name": "TBXAS1",
"activity": [
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "P24557",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24557"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "",
"evidence": [
{
"id": "P24557",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24557"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P24557",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24557"
}
]
}
]
},
{
"uniprot_ac": "P24903",
"gene_name": "CYP2F1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P24903",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24903"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P24903",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24903"
}
]
}
]
},
{
"uniprot_ac": "P28649",
"gene_name": "Cyp19a1",
"activity": [
{
"ec_number": "1.14.14.14",
"activity": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P28649",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28649"
}
]
},
{
"ec_number": "1.14.14.14",
"activity": "",
"evidence": [
{
"id": "P28649",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28649"
}
]
}
]
},
{
"uniprot_ac": "P33260",
"gene_name": "CYP2C18",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33260"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33260",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33260"
}
]
}
]
},
{
"uniprot_ac": "P33261",
"gene_name": "CYP2C19",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.51",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.52",
"activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.53",
"activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.75",
"activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33261"
}
]
}
]
},
{
"uniprot_ac": "P33272",
"gene_name": "Cyp2b12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33272",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33272"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33272",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33272"
}
]
}
]
},
{
"uniprot_ac": "P33273",
"gene_name": "Cyp2c55",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P33273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33273"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P33273",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33273"
}
]
}
]
},
{
"uniprot_ac": "P36423",
"gene_name": "Tbxas1",
"activity": [
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P36423",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36423"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "P36423",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36423"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "",
"evidence": [
{
"id": "P36423",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36423"
}
]
}
]
},
{
"uniprot_ac": "P49430",
"gene_name": "Tbxas1",
"activity": [
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "P49430",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49430"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "P49430",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49430"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "",
"evidence": [
{
"id": "P49430",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49430"
}
]
}
]
},
{
"uniprot_ac": "P51538",
"gene_name": "Cyp3a9",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P51538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51538"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51538"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51538"
}
]
}
]
},
{
"uniprot_ac": "P51589",
"gene_name": "CYP2J2",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
},
{
"ec_number": "5.4.4.7",
"activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
},
{
"ec_number": "1.14.14.73",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
},
{
"ec_number": "1.14.14.74",
"activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51589"
}
]
}
]
},
{
"uniprot_ac": "P51590",
"gene_name": "Cyp2j3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51590",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51590"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51590",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51590"
}
]
}
]
},
{
"uniprot_ac": "P51870",
"gene_name": "Cyp4f5",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51870"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51870",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51870"
}
]
}
]
},
{
"uniprot_ac": "P51871",
"gene_name": "Cyp4f6",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P51871",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51871"
}
]
}
]
},
{
"uniprot_ac": "P56593",
"gene_name": "Cyp2a12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56593",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56593"
}
]
}
]
},
{
"uniprot_ac": "P56654",
"gene_name": "Cyp2c37",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56654"
}
]
}
]
},
{
"uniprot_ac": "P56655",
"gene_name": "Cyp2c38",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56655"
}
]
}
]
},
{
"uniprot_ac": "P56656",
"gene_name": "Cyp2c39",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P56656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56656"
}
]
}
]
},
{
"uniprot_ac": "P56657",
"gene_name": "Cyp2c40",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "P56657",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P56657"
}
]
}
]
},
{
"uniprot_ac": "P78329",
"gene_name": "CYP4F2",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.78",
"activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.79",
"activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.94",
"activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P78329",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78329"
}
]
}
]
},
{
"uniprot_ac": "P98187",
"gene_name": "CYP4F8",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "P98187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P98187"
}
]
}
]
},
{
"uniprot_ac": "Q02928",
"gene_name": "CYP4A11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
},
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q02928",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02928"
}
]
}
]
},
{
"uniprot_ac": "Q05421",
"gene_name": "Cyp2e1",
"activity": [
{
"ec_number": "1.14.13.n7",
"activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
},
{
"ec_number": "1.14.13.n7",
"activity": "",
"evidence": [
{
"id": "Q05421",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05421"
}
]
}
]
},
{
"uniprot_ac": "Q08477",
"gene_name": "CYP4F3",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.79",
"activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.94",
"activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q08477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08477"
}
]
}
]
},
{
"uniprot_ac": "Q16647",
"gene_name": "PTGIS",
"activity": [
{
"ec_number": "5.3.99.4",
"activity": "prostaglandin H2 = prostaglandin I2.",
"evidence": [
{
"id": "Q16647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16647"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q16647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16647"
}
]
},
{
"ec_number": "5.3.99.4",
"activity": "",
"evidence": [
{
"id": "Q16647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16647"
}
]
}
]
},
{
"uniprot_ac": "Q16678",
"gene_name": "CYP1B1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q16678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16678"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q16678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16678"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q16678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16678"
}
]
}
]
},
{
"uniprot_ac": "Q16696",
"gene_name": "CYP2A13",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q16696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16696"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q16696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16696"
}
]
}
]
},
{
"uniprot_ac": "Q4V8D1",
"gene_name": "Cyp2u1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q4V8D1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4V8D1"
}
]
}
]
},
{
"uniprot_ac": "Q62969",
"gene_name": "Ptgis",
"activity": [
{
"ec_number": "5.3.99.4",
"activity": "prostaglandin H2 = prostaglandin I2.",
"evidence": [
{
"id": "Q62969",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62969"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q62969",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62969"
}
]
},
{
"ec_number": "5.3.99.4",
"activity": "",
"evidence": [
{
"id": "Q62969",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62969"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "",
"evidence": [
{
"id": "Q62969",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62969"
}
]
}
]
},
{
"uniprot_ac": "Q64429",
"gene_name": "Cyp1b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64429",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64429"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q64429",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64429"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64429",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64429"
}
]
}
]
},
{
"uniprot_ac": "Q64458",
"gene_name": "Cyp2c29",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64458"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64458"
}
]
}
]
},
{
"uniprot_ac": "Q64459",
"gene_name": "Cyp3a11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64459"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64459",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64459"
}
]
}
]
},
{
"uniprot_ac": "Q64462",
"gene_name": "Cyp4b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64462"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64462",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64462"
}
]
}
]
},
{
"uniprot_ac": "Q64464",
"gene_name": "Cyp3a13",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64464"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64464"
}
]
}
]
},
{
"uniprot_ac": "Q64481",
"gene_name": "Cyp3a16",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64481",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64481"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64481",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64481"
}
]
}
]
},
{
"uniprot_ac": "Q64581",
"gene_name": "Cyp3a18",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64581"
}
]
}
]
},
{
"uniprot_ac": "Q64583",
"gene_name": "Cyp2b15",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64583"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64583"
}
]
}
]
},
{
"uniprot_ac": "Q64678",
"gene_name": "Cyp1b1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64678"
}
]
}
]
},
{
"uniprot_ac": "Q64680",
"gene_name": "Cyp2d4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q64680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64680"
}
]
}
]
},
{
"uniprot_ac": "Q6V0L0",
"gene_name": "CYP26C1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6V0L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V0L0"
}
]
}
]
},
{
"uniprot_ac": "Q6XVG2",
"gene_name": "Cyp2c54",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q6XVG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XVG2"
}
]
}
]
},
{
"uniprot_ac": "Q7Z449",
"gene_name": "CYP2U1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q7Z449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z449"
}
]
},
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q7Z449",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z449"
}
]
}
]
},
{
"uniprot_ac": "Q86W10",
"gene_name": "CYP4Z1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q86W10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86W10"
}
]
},
{
"ec_number": "1.14.14.130",
"activity": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q86W10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86W10"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q86W10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86W10"
}
]
}
]
},
{
"uniprot_ac": "Q8CIM7",
"gene_name": "Cyp2d26",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q8CIM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIM7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q8CIM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIM7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q8CIM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIM7"
}
]
}
]
},
{
"uniprot_ac": "Q91WL5",
"gene_name": "Cyp4a12a",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q91WL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WL5"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q91WL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WL5"
}
]
}
]
},
{
"uniprot_ac": "Q91X77",
"gene_name": "Cyp2c50",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q91X77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91X77"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q91X77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91X77"
}
]
}
]
},
{
"uniprot_ac": "Q96SQ9",
"gene_name": "CYP2S1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q96SQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SQ9"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q96SQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SQ9"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "Q96SQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SQ9"
}
]
}
]
},
{
"uniprot_ac": "Q9BYJ1",
"gene_name": "ALOXE3",
"activity": [
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q9BYJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYJ1"
}
]
},
{
"ec_number": "5.4.4.7",
"activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.",
"evidence": [
{
"id": "Q9BYJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYJ1"
}
]
}
]
},
{
"uniprot_ac": "Q9CX98",
"gene_name": "Cyp2u1",
"activity": [
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9CX98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CX98"
}
]
}
]
},
{
"uniprot_ac": "Q9D816",
"gene_name": "Cyp2c55",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9D816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D816"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9D816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D816"
}
]
}
]
},
{
"uniprot_ac": "Q9DBX6",
"gene_name": "Cyp2s1",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "5.3.99.5",
"activity": "prostaglandin H2 = thromboxane A2.",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9DBX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBX6"
}
]
}
]
},
{
"uniprot_ac": "Q9EQW4",
"gene_name": "Cyp3a44",
"activity": [
{
"ec_number": "1.14.14.-",
"activity": "",
"evidence": [
{
"id": "Q9EQW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQW4"
}
]
}
]
},
{
"uniprot_ac": "Q9HB55",
"gene_name": "CYP3A43",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9HB55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HB55"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9HB55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HB55"
}
]
}
]
},
{
"uniprot_ac": "Q9HBI6",
"gene_name": "CYP4F11",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9HBI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBI6"
}
]
},
{
"ec_number": "1.14.14.80",
"activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9HBI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBI6"
}
]
},
{
"ec_number": "1.14.14.78",
"activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9HBI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBI6"
}
]
},
{
"ec_number": "1.14.14.79",
"activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9HBI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBI6"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9HBI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBI6"
}
]
}
]
},
{
"uniprot_ac": "Q9HCS2",
"gene_name": "CYP4F12",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9HCS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCS2"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9HCS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCS2"
}
]
}
]
},
{
"uniprot_ac": "Q9JMA7",
"gene_name": "Cyp3a41a",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9JMA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JMA7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9JMA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JMA7"
}
]
}
]
},
{
"uniprot_ac": "Q9QXF7",
"gene_name": "CYP2J4",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9QXF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QXF7"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9QXF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QXF7"
}
]
}
]
},
{
"uniprot_ac": "Q9WV07",
"gene_name": "Aloxe3",
"activity": [
{
"ec_number": "4.2.1.152",
"activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.",
"evidence": [
{
"id": "Q9WV07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV07"
}
]
},
{
"ec_number": "5.4.4.7",
"activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.",
"evidence": [
{
"id": "Q9WV07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV07"
}
]
}
]
},
{
"uniprot_ac": "Q9WV19",
"gene_name": "Cyp2g1",
"activity": [
{
"ec_number": "1.14.14.1",
"activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].",
"evidence": [
{
"id": "Q9WV19",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV19"
}
]
},
{
"ec_number": "1.14.14.1",
"activity": "",
"evidence": [
{
"id": "Q9WV19",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV19"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [],
"cluster_types": [
{
"name": "homologset.mgi",
"label": "MGI Homologs"
},
{
"name": "homologset.oma",
"label": "OMA Homologs"
}
],
"sequence_features": {
"n_linked_sites": [],
"o_linked_sites": [
69
],
"snv_sites": [
69,
83,
200,
229,
277,
282,
289,
302,
388,
393,
436,
490
],
"glycation_sites": [],
"phosphorylation_sites": [
82
],
"sequon_annotation_sites": []
},
"section_stats": [
{
"table_id": "glycosylation",
"table_stats": [
{
"field": "total",
"count": 1
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 1
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_reported_with_glycan",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_predicted",
"table_stats": [
{
"field": "total",
"count": 1
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 1
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_automatic_literature_mining",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "phosphorylation",
"table_stats": [
{
"field": "total",
"count": 1
},
{
"field": "total_sites",
"count": 1
}
],
"sort_fields": [
"start_pos",
"end_pos",
"kinase_uniprot_canonical_ac",
"kinase_gene_name",
"residue",
"comment",
"site_lbl"
]
},
{
"table_id": "snv",
"table_stats": [
{
"field": "total",
"count": 12
},
{
"field": "total_sites",
"count": 12
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "snv_disease",
"table_stats": [
{
"field": "total",
"count": 5
},
{
"field": "total_sites",
"count": 5
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "snv_non_disease",
"table_stats": [
{
"field": "total",
"count": 7
},
{
"field": "total_sites",
"count": 7
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "publication",
"table_stats": [
{
"field": "total",
"count": 94
}
],
"sort_fields": [
"title",
"journal",
"date",
"authors"
]
}
]
}