{
    "uniprot_canonical_ac": "P05095-1",
    "uniprot_ac": "P05095",
    "uniprot_id": "ACTNA_DICDI",
    "mass": {
        "chemical_mass": 97358.0,
        "monoisotopic_mass": 97358.0
    },
    "refseq": {
        "ac": "XP_646979",
        "name": "actin binding protein A",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646979"
    },
    "gene_names": [
        {
            "name": "abpA",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P05095",
            "id": "P05095"
        },
        {
            "name": "DDB_G0268632",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P05095",
            "id": "P05095"
        },
        {
            "name": "abpA",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646979",
            "id": "XP_646979"
        },
        {
            "name": "actnA",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P05095",
            "id": "P05095"
        }
    ],
    "protein_names": [
        {
            "name": "Alpha-actinin A",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P05095"
        },
        {
            "name": "Actin-binding protein A",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P05095"
        },
        {
            "name": "F-actin cross-linking protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P05095"
        },
        {
            "name": "actin binding protein A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646979",
            "id": "XP_646979"
        },
        {
            "name": "actin bundling protein; alpha actinin; alpha actinin 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646979",
            "id": "XP_646979"
        }
    ],
    "function": [
        {
            "annotation": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Increases the actin-stimulated ATPase activity of myosin. Involved in vegetative cell growth, phagocytosis, motility and development, probably through stabilization of the actin network in the cortical cytoskeleton.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095#function"
                },
                {
                    "database": "PubMed",
                    "id": "3956480",
                    "url": "https://glygen.org/publication/PubMed/3956480"
                },
                {
                    "database": "PubMed",
                    "id": "10704840",
                    "url": "https://glygen.org/publication/PubMed/10704840"
                },
                {
                    "database": "PubMed",
                    "id": "10413681",
                    "url": "https://glygen.org/publication/PubMed/10413681"
                },
                {
                    "database": "PubMed",
                    "id": "6746725",
                    "url": "https://glygen.org/publication/PubMed/6746725"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                },
                {
                    "database": "PubMed",
                    "id": "1732064",
                    "url": "https://glygen.org/publication/PubMed/1732064"
                },
                {
                    "database": "PubMed",
                    "id": "8937986",
                    "url": "https://glygen.org/publication/PubMed/8937986"
                },
                {
                    "database": "PubMed",
                    "id": "10411959",
                    "url": "https://glygen.org/publication/PubMed/10411959"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 742,
            "end_pos": 742,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Abolishes cross-linking activity and reduces calcium binding by 55%; when associated with A-744; A-746 and A-753.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 744,
            "end_pos": 744,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Abolishes cross-linking activity and reduces calcium binding by 55%; when associated with A-742; A-746 and A-753.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 746,
            "end_pos": 746,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Abolishes cross-linking activity and reduces calcium binding by 55%; when associated with A-742; A-744 and A-753.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 753,
            "end_pos": 753,
            "sequence_org": "E",
            "sequence_mut": "A",
            "comment": "Abolishes cross-linking activity and reduces calcium binding by 55%; when associated with A-742; A-744 and A-746.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 778,
            "end_pos": 778,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Decreases sensitivity to inhibition by calcium; when associated with A-780; A-786 and A-789.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 780,
            "end_pos": 780,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Decreases sensitivity to inhibition by calcium; when associated with A-778; A-786 and A-789.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 786,
            "end_pos": 786,
            "sequence_org": "S",
            "sequence_mut": "A",
            "comment": "Decreases sensitivity to inhibition by calcium; when associated with A-778; A-780 and A-789.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        },
        {
            "start_pos": 789,
            "end_pos": 789,
            "sequence_org": "E",
            "sequence_mut": "A",
            "comment": "Decreases sensitivity to inhibition by calcium; when associated with A-778; A-780 and A-786.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                },
                {
                    "database": "PubMed",
                    "id": "8486739",
                    "url": "https://glygen.org/publication/PubMed/8486739"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Dictyostelium discoideum",
            "taxid": 44689,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                }
            ],
            "common_name": "Cellular slime molds"
        }
    ],
    "gene": [
        {
            "name": "abpA",
            "url": "https://www.uniprot.org/uniprot/P05095",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "cd00051",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00051",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd00176",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00176",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd21214",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21214",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd21216",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21216",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "DDB_G0268632",
            "url": "http://dictybase.org/gene/DDB_G0268632",
            "database": "dictyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "8616670",
            "url": "https://www.ncbi.nlm.nih.gov/gene/8616670",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001589",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001589",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR001715",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001715",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002017",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002017",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002048",
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            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011992",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "IPR014837",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014837",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018159",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018159",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018247",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036872",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036872",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ddi:DDB_G0268632",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0268632",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "RYDNGYE",
            "url": "https://omabrowser.org/oma/group/RYDNGYE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11915",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11915",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11915:SF435",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11915:SF435",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1G8X",
            "url": "https://www.rcsb.org/structure/1G8X",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "4PD3",
            "url": "https://www.rcsb.org/structure/4PD3",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "5I4E",
            "url": "https://www.rcsb.org/structure/5I4E",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "5JLH",
            "url": "https://www.rcsb.org/structure/5JLH",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF00307",
            "url": "http://pfam.xfam.org/family/PF00307",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00435",
            "url": "http://pfam.xfam.org/family/PF00435",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08726",
            "url": "http://pfam.xfam.org/family/PF08726",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13499",
            "url": "http://pfam.xfam.org/family/PF13499",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_P05095",
            "url": "http://purl.obolibrary.org/obo/PR_P05095",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-DDI-114608",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-114608",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-6798695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6798695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-6807878",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6807878",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-9013418",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013418",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-9013420",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013420",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-9013424",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-9013424",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_646979",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646979",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P05095",
            "url": "https://www.uniprot.org/uniprot/P05095",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "P05095-1",
            "url": "https://www.uniprot.org/uniprot/P05095-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSEEPTPVSGNDKQLLNKAWEITQKKTFTAWCNSHLRKLGSSIEQIDTDFTDGIKLAQLLEVISNDPVFKVNKTPKLRIHNIQNVGLCLKHIESHGVKLVGIGAEELVDKNLKMTLGMIWTIILRFAIQDISIEELSAKEALLLWCQRKTEGYDRVKVGNFHTSFQDGLAFCALIHKHRPDLINFDSLNKDDKAGNLQLAFDIAEKELDIPKMLDVSDMLDVVRPDERSVMTYVAQYYHHFSASRKAETAGKQVGKVLDTFMLLEQTKSDYLKRANELVQWINDKQASLESRDFGDSIESVQSFMNAHKEYKKTEKPPKGQEVSELEAIYNSLQTKLRLIKREPFVAPAGLTPNEIDSTWSALEKAEQEHAEALRIELKRQKKIAVLLQKYNRILKKLENWATTKSVYLGSNETGDSITAVQAKLKNLEAFDGECQSLEGQSNSDLLSILAQLTELNYNGVPELTERKDTFFAQQWTGVKSSAETYKNTLLAELERLQKIEDSLVEFAKRAAQLNVWIEAADDHVFDPINVDSVQGVQEIQEKFDAFLHDQSQQFAELEALAALTQQLRELGRSENDYSVISYDELSAKWNNLLAGIEERKVQLANELTTQTNNDVLCQSFSVKANEISDYVRVTLDAISQNTSSDPQEQLNNIRAIITAHAEKKPELDELYTIASQLEEAQVVDNKHTQHSLESIKLKWDKLNTLAKKNEQVVEGEILAKQLTGVTAEELSEFKACFSHFDKDNDNKLNRLEFSSCLKSIGDELTEEQLNQVISKIDTDGNGTISFEEFIDYMVSSRKGTDSVESTKAAFKVMAEDKDFITEAQIRAAISDSKQIDYLLASMPAVEGGFDYNSFAEKLYQ",
        "length": 861,
        "header": "sp|P05095-1|ACTNA_DICDI Isoform 1 of Alpha-actinin A  OS=Dictyostelium discoideum OX=44689 GN=abpA PE=1 SV=2 CANONICAL=P05095-1"
    },
    "isoforms": [
        {
            "isoform_ac": "P05095-1",
            "url": "",
            "sequence": {
                "sequence": "MSEEPTPVSGNDKQLLNKAWEITQKKTFTAWCNSHLRKLGSSIEQIDTDFTDGIKLAQLLEVISNDPVFKVNKTPKLRIHNIQNVGLCLKHIESHGVKLVGIGAEELVDKNLKMTLGMIWTIILRFAIQDISIEELSAKEALLLWCQRKTEGYDRVKVGNFHTSFQDGLAFCALIHKHRPDLINFDSLNKDDKAGNLQLAFDIAEKELDIPKMLDVSDMLDVVRPDERSVMTYVAQYYHHFSASRKAETAGKQVGKVLDTFMLLEQTKSDYLKRANELVQWINDKQASLESRDFGDSIESVQSFMNAHKEYKKTEKPPKGQEVSELEAIYNSLQTKLRLIKREPFVAPAGLTPNEIDSTWSALEKAEQEHAEALRIELKRQKKIAVLLQKYNRILKKLENWATTKSVYLGSNETGDSITAVQAKLKNLEAFDGECQSLEGQSNSDLLSILAQLTELNYNGVPELTERKDTFFAQQWTGVKSSAETYKNTLLAELERLQKIEDSLVEFAKRAAQLNVWIEAADDHVFDPINVDSVQGVQEIQEKFDAFLHDQSQQFAELEALAALTQQLRELGRSENDYSVISYDELSAKWNNLLAGIEERKVQLANELTTQTNNDVLCQSFSVKANEISDYVRVTLDAISQNTSSDPQEQLNNIRAIITAHAEKKPELDELYTIASQLEEAQVVDNKHTQHSLESIKLKWDKLNTLAKKNEQVVEGEILAKQLTGVTAEELSEFKACFSHFDKDNDNKLNRLEFSSCLKSIGDELTEEQLNQVISKIDTDGNGTISFEEFIDYMVSSRKGTDSVESTKAAFKVMAEDKDFITEAQIRAAISDSKQIDYLLASMPAVEGGFDYNSFAEKLYQ",
                "length": 861,
                "header": "sp|P05095-1|ACTNA_DICDI Isoform 1 of Alpha-actinin A  OS=Dictyostelium discoideum OX=44689 GN=abpA PE=1 SV=2 CANONICAL=P05095-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Computer-assisted morphometry of cell-substratum contacts.",
            "journal": "Croatian medical journal",
            "date": "1999-09",
            "authors": "Weber I",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10411959",
                    "url": "https://glygen.org/publication/PubMed/10411959"
                }
            ]
        },
        {
            "title": "Three actin cross-linking proteins, the 34 kDa actin-bundling protein, alpha-actinin and gelation factor (ABP-120), have both unique and redundant roles in the growth and development of Dictyostelium.",
            "journal": "Journal of cell science",
            "date": "1999-08",
            "authors": "Rivero F, Furukawa R, Fechheimer M, Noegel A A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10413681",
                    "url": "https://glygen.org/publication/PubMed/10413681"
                }
            ]
        },
        {
            "title": "Severe developmental defects in Dictyostelium null mutants for actin-binding proteins.",
            "journal": "Mechanisms of development",
            "date": "2000-03-01",
            "authors": "Ponte E, Rivero F, Fechheimer M, Noegel A, Bozzaro S",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P05095",
                    "url": "https://www.uniprot.org/uniprot/P05095"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10704840",
                    "url": "https://glygen.org/publication/PubMed/10704840"
                }
            ]
        },
        {
            "title": "Structure of a genetically engineered molecular motor.",
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