{ "uniprot_canonical_ac": "P04798-1", "uniprot_ac": "P04798", "uniprot_id": "CP1A1_HUMAN", "mass": { "chemical_mass": 58165.0, "monoisotopic_mass": 58165.0 }, "refseq": { "ac": "NP_000490", "name": "cytochrome P450 1A1 isoform 1", "summary": "This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" }, "gene_names": [ { "name": "CYP1A1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P04798", "id": "P04798" }, { "name": "AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490", "id": "NP_000490" }, { "name": "CYP1A1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490", "id": "NP_000490" } ], "protein_names": [ { "name": "Cytochrome P450 1A1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P04798" }, { "name": "1.14.14.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "4.2.1.152", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "CYPIA1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "Cytochrome P450 form 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "Cytochrome P450-C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "Cytochrome P450-P1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "Hydroperoxy icosatetraenoate dehydratase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04798" }, { "name": "cytochrome P450 1A1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490", "id": "NP_000490" }, { "name": "flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; cytochrome P450 1A1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; hydroperoxy icosatetraenoate dehydratase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490", "id": "NP_000490" } ], "function": [ { "annotation": "A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301, PubMed:15041462, PubMed:18577768, PubMed:19965576, PubMed:20972997, PubMed:10681376). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15-alpha and C16-alpha positions (PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15805301). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (PubMed:15041462, PubMed:18577768). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:15041462, PubMed:19965576, PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system (PubMed:20972997). Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (PubMed:15041462). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195).", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798#function" }, { "database": "PubMed", "id": "11555828", "url": "https://glygen.org/publication/PubMed/11555828" }, { "database": "PubMed", "id": "15805301", "url": "https://glygen.org/publication/PubMed/15805301" }, { "database": "PubMed", "id": "10681376", "url": "https://glygen.org/publication/PubMed/10681376" }, { "database": "PubMed", "id": "19965576", "url": "https://glygen.org/publication/PubMed/19965576" }, { "database": "PubMed", "id": "12865317", "url": "https://glygen.org/publication/PubMed/12865317" }, { "database": "PubMed", "id": "20972997", "url": "https://glygen.org/publication/PubMed/20972997" }, { "database": "PubMed", "id": "14559847", "url": "https://glygen.org/publication/PubMed/14559847" }, { "database": "PubMed", "id": "18577768", "url": "https://glygen.org/publication/PubMed/18577768" }, { "database": "PubMed", "id": "21068195", "url": "https://glygen.org/publication/PubMed/21068195" }, { "database": "PubMed", "id": "15041462", "url": "https://glygen.org/publication/PubMed/15041462" } ] }, { "annotation": "Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris.", "evidence": [ { "database": "RefSeq", "id": "NP_000490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" }, { "database": "PubMed", "id": "36921208", "url": "https://glygen.org/publication/PubMed/36921208" } ] }, { "annotation": "Association of CYP1A1 T3801C (rs4646903) variant with the susceptibility and progression of B-chronic lymphocytic Leukemia (B-CLL) in the Egyptian population.", "evidence": [ { "database": "RefSeq", "id": "NP_000490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" }, { "database": "PubMed", "id": "37506988", "url": "https://glygen.org/publication/PubMed/37506988" } ] }, { "annotation": "CYP1A1 common gene polymorphisms and ischemic stroke risk: a meta-analysis and a structural examination.", "evidence": [ { "database": "RefSeq", "id": "NP_000490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" }, { "database": "PubMed", "id": "37195087", "url": "https://glygen.org/publication/PubMed/37195087" } ] }, { "annotation": "Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.", "evidence": [ { "database": "UniProtKB", "id": "A4F3V8", "url": "https://www.uniprot.org/uniprot/A4F3V8#function" }, { "database": "UniProtKB", "id": "RU368045", "url": "https://www.uniprot.org/uniprot/RU368045#function" }, { "database": "UniProtKB", "id": "E7EMT5", "url": "https://www.uniprot.org/uniprot/E7EMT5#function" } ] }, { "annotation": "Determination of SNP frequencies in the CYP1A1_CYP1A2 locus.", "evidence": [ { "database": "RefSeq", "id": "NP_000490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" }, { "database": "PubMed", "id": "15643613", "url": "https://glygen.org/publication/PubMed/15643613" } ] }, { "annotation": "Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" }, { "database": "PubMed", "id": "37511239", "url": "https://glygen.org/publication/PubMed/37511239" } ] }, { "annotation": "This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_000490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000490" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P04798", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04798" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 221, "end_pos": 221, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NLN->NLS).", "chr_id": "15", "chr_pos": "74722436", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N221", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1373130092", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1373130092" }, { "id": "rs1373130092", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1373130092#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 224, "end_pos": 224, "sequence_org": "F", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNF->NNS).", "chr_id": "15", "chr_pos": "74722427", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "F224", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760213300", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760213300" }, { "id": "rs760213300", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760213300" }, { "id": "rs760213300", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs760213300#frequency_tab" }, { "id": "rs760213300", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760213300" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 246, "end_pos": 246, "sequence_org": "P", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NAS).", "chr_id": "15", "chr_pos": "74722362", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P246", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760213300", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760213300" }, { "id": "rs760213300", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760213300" }, { "id": "rs760213300", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs760213300#frequency_tab" }, { "id": "rs760213300", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760213300" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 246, "end_pos": 246, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NSS).", "chr_id": "15", "chr_pos": "74722362", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P246", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1567196287", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1567196287" }, { "id": "rs1567196287", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1567196287" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 280, "end_pos": 280, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DIT->NIT).", "chr_id": "15", "chr_pos": "74721705", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D280", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs747475208", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747475208" }, { "id": "rs747475208", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747475208" }, { "id": "rs747475208", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs747475208" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 299, "end_pos": 299, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAN->NAS).", "chr_id": "15", "chr_pos": "74721647", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N299", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P04798", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04798" } ], "glycoeffect": [], "start_pos": 377, "end_pos": 377, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P04798", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04798" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04798" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P04798", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04798" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS", "length": 512, "header": "sp|P04798-1|CP1A1_HUMAN Isoform 1 of Cytochrome P450 1A1 OS=Homo sapiens OX=9606 GN=CYP1A1 PE=1 SV=1 CANONICAL=P04798-1" }, "isoforms": [ { "isoform_ac": "A4F3V8-1", "url": "", "sequence": { "sequence": "MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD", "length": 175, "header": "tr|A4F3V8-1|A4F3V8_HUMAN Computationally mapped isoform of Cytochrome P450 1A OS=Homo sapiens OX=9606 GN=CYP1A1 PE=1 SV=1 CANONICAL=P04798-1" }, "locus": { "chromosome": "15", "start_pos": 74722314, "end_pos": 74720720, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000566503.1", "url": "https://www.ensembl.org/id/ENST00000566503.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000455846.1", "url": "https://www.ensembl.org/id/ENSP00000455846.1" } ] } }, { "isoform_ac": "E7EMT5-1", "url": "", "sequence": { "sequence": "MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHRKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS", "length": 483, "header": "tr|E7EMT5-1|E7EMT5_HUMAN Computationally mapped isoform of Cytochrome P450 1A OS=Homo sapiens OX=9606 GN=CYP1A1 PE=1 SV=1 CANONICAL=P04798-1" }, "locus": { "chromosome": "15", "start_pos": 74723097, "end_pos": 74720492, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000395049.8", "url": "https://www.ensembl.org/id/ENST00000395049.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000378489.4", "url": "https://www.ensembl.org/id/ENSP00000378489.4" } ] } }, { "isoform_ac": "P04798-1", "url": "", "sequence": { "sequence": "MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS", "length": 512, "header": "sp|P04798-1|CP1A1_HUMAN Isoform 1 of Cytochrome P450 1A1 OS=Homo sapiens OX=9606 GN=CYP1A1 PE=1 SV=1 CANONICAL=P04798-1" }, "locus": { "chromosome": "15", "start_pos": 74723097, "end_pos": 74720492, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000567032.5", "url": "https://www.ensembl.org/id/ENST00000567032.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000456585.1", "url": "https://www.ensembl.org/id/ENSP00000456585.1" } ] } }, { "isoform_ac": "P04798-2", "url": "", "sequence": { "sequence": "MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRT", "length": 189, "header": "sp|P04798-2|CP1A1_HUMAN Isoform 2 of Cytochrome P450 1A1 OS=Homo sapiens OX=9606 GN=CYP1A1 PE=1 SV=1 CANONICAL=P04798-1" }, "locus": { "chromosome": "15", "start_pos": 74723097, "end_pos": 74722338, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569630.5", "url": "https://www.ensembl.org/id/ENST00000569630.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000455051.1", "url": "https://www.ensembl.org/id/ENSP00000455051.1" } ] } }, { "isoform_ac": "P04798-3", "url": "", "sequence": { "sequence": "MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ", "length": 157, "header": "sp|P04798-3|CP1A1_HUMAN Isoform 3 of Cytochrome P450 1A1 OS=Homo sapiens OX=9606 GN=CYP1A1 PE=1 SV=1 CANONICAL=P04798-1" }, "locus": { "chromosome": "15", "start_pos": 74722314, "end_pos": 74720966, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000564596.5", "url": "https://www.ensembl.org/id/ENST00000564596.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000457668.1", "url": "https://www.ensembl.org/id/ENSP00000457668.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 54, "start_aa": "Thr", "end_pos": 54, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr54", "evidence": [ { "id": "P04798", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04798" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "predicted", "site_seq": "S", "relation": "attached", "comment": "O-linked (GlcNAc) serine O-GlcNAcylation", "start_pos": 67, "start_aa": "Ser", "end_pos": 67, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser67", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 360, "end_pos": 360, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P04798", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04798" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "phospho.ELM", "id": "P04798", "url": "http://phospho.elm.eu.org/byAccession/P04798.html" } ], "site_lbl": "Ser360" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "1999", "authors": "Lanza DL, Code E, Crespi CL, Gonzalez FJ, Yost GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "10383923", "url": "https://glygen.org/publication/PubMed/10383923" } ] }, { "title": "Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "2000-03", "authors": "Chen H, Howald W N, Juchau M R", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "10681376", "url": "https://glygen.org/publication/PubMed/10681376" } ] }, { "title": "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms.", "journal": "Pharmacogenetics", "date": "2000", "authors": "Smart J, Daly A K", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "10739168", "url": "https://glygen.org/publication/PubMed/10739168" } ] }, { "title": "The murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alpha.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Cheema SK, Agellon LB", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "10777541", "url": "https://glygen.org/publication/PubMed/10777541" } ] }, { "title": "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.", "journal": "Pharmacogenetics", "date": "2001", "authors": "Corchero J, Pimprale S, Kimura S, Gonzalez F J", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "11207026", "url": "https://glygen.org/publication/PubMed/11207026" } ] }, { "title": "Alternative splicing and tissue-specific transcription of human and rodent ubiquitous 5-aminolevulinate synthase (ALAS1) genes.", "journal": "Biochimica et biophysica acta", "date": "2001", "authors": "Roberts AG, Elder GH", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "11267664", "url": "https://glygen.org/publication/PubMed/11267664" } ] }, { "title": "Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population.", "journal": "Human mutation", "date": "2001", "authors": "Chevalier D, Allorge D, Lo-Guidice JM, Cauffiez C, Lhermitte M, Lafitte JJ, Broly F", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "11295847", "url": "https://glygen.org/publication/PubMed/11295847" } ] }, { "title": "Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.", "journal": "Metabolism: clinical and experimental", "date": "2001", "authors": "Badawi AF, Cavalieri EL, Rogan EG", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "11555828", "url": "https://glygen.org/publication/PubMed/11555828" } ] }, { "title": "Polymorphisms in CYP1A1 and smoking: no association with breast cancer risk.", "journal": "Carcinogenesis", "date": "2001", "authors": "Basham VM, Pharoah PD, Healey CS, Luben RN, Day NE, Easton DF, Ponder BA, Dunning AM", "evidence": [ { "database": "Entrez", "id": "1543", "url": "https://www.ncbi.nlm.nih.gov/gene/1543" } ], "reference": [ { "type": "PubMed", "id": "11698341", "url": "https://glygen.org/publication/PubMed/11698341" } ] }, { "title": "Peroxisome proliferator-activated receptor alpha (PPARalpha ) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "12118000", "url": "https://glygen.org/publication/PubMed/12118000" } ] }, { "title": "Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.", "journal": "Journal of lipid research", "date": "2002", "authors": "Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "12177166", "url": "https://glygen.org/publication/PubMed/12177166" } ] }, { "title": "Prostaglandin and leukotriene omega-hydroxylases.", "journal": "Prostaglandins & other lipid mediators", "date": "2002", "authors": "Kikuta Y, Kusunose E, Kusunose M", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142816", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816" } ], "reference": [ { "type": "PubMed", "id": "12432928", "url": "https://glygen.org/publication/PubMed/12432928" } ] }, { "title": "Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions.", "journal": "Archives of biochemistry and biophysics", "date": "2003", "authors": "Guengerich FP", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "12464245", "url": "https://glygen.org/publication/PubMed/12464245" } ] }, { "title": "Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas.", "journal": "Prostaglandins, leukotrienes, and essential fatty acids", "date": "2002", "authors": "Werner K, Schaefer WR, Schweer H, Deppert WR, Karck U, Zahradnik HP", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142670", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670" } ], "reference": [ { "type": "PubMed", "id": "12468260", "url": "https://glygen.org/publication/PubMed/12468260" } ] }, { "title": "Regulation of P450 4A expression by peroxisome proliferator activated receptors.", "journal": "Toxicology", "date": "2002", "authors": "Johnson EF, Hsu MH, Savas U, Griffin KJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "12505311", "url": "https://glygen.org/publication/PubMed/12505311" } ] }, { "title": "The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Barbier O, Villeneuve L, Bocher V, Fontaine C, Torra IP, Duhem C, Kosykh V, Fruchart JC, Guillemette C, Staels B", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "12582161", "url": "https://glygen.org/publication/PubMed/12582161" } ] }, { "title": "Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-9018681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018681" } ], "reference": [ { "type": "PubMed", "id": "12590139", "url": "https://glygen.org/publication/PubMed/12590139" } ] }, { "title": "Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation.", "journal": "The pharmacogenomics journal", "date": "2003", "authors": "Xie HJ, Yasar U, Lundgren S, Griskevicius L, Terelius Y, Hassan M, Rane A", "evidence": [ { "database": "Reactome", "id": "R-HSA-211981", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-211981" } ], "reference": [ { "type": "PubMed", "id": "12629583", "url": "https://glygen.org/publication/PubMed/12629583" } ] }, { "title": "Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.", "journal": "Endocrinology", "date": "2003-08", "authors": "Lee Anthony J, Cai May Xiaoxin, Thomas Paul E, Conney Allan H, Zhu Bao Ting", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "12865317", "url": "https://glygen.org/publication/PubMed/12865317" } ] }, { "title": "Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol.", "journal": "Cancer research", "date": "2003", "authors": "Lee AJ, Conney AH, Zhu BT", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "14559847", "url": "https://glygen.org/publication/PubMed/14559847" } ] }, { "title": "CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142816", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142816" } ], "reference": [ { "type": "PubMed", "id": "14660610", "url": "https://glygen.org/publication/PubMed/14660610" } ] }, { "title": "Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid.", "journal": "Biochemical pharmacology", "date": "2004-04-15", "authors": "Schwarz Dieter, Kisselev Pyotr, Ericksen Spencer S, Szklarz Grazyna D, Chernogolov Alexey, Honeck Horst, Schunck Wolf-Hagen, Roots Ivar", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "reference": [ { "type": "PubMed", "id": "15041462", "url": "https://glygen.org/publication/PubMed/15041462" } ] }, { "title": "Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter.", "journal": "International journal of molecular medicine", "date": "2004", "authors": "Shimamoto Y, Hirota K, Fukamizu A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1989781", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989781" } ], "reference": [ { "type": "PubMed", "id": "15067378", "url": "https://glygen.org/publication/PubMed/15067378" } ] }, { "title": "Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis.", "journal": "Biochemistry", "date": "2004", "authors": "Gomez GA, Morisseau C, Hammock BD, Christianson DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142670", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142670" } ], "reference": [ { "type": "PubMed", "id": "15096040", "url": 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"id": "GO:0051879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051879", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "Hsp70 protein binding", "id": "GO:0030544", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030544", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "monooxygenase activity", "id": "GO:0004497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004497", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "oxygen binding", "id": "GO:0019825", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019825", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on diphenols and related substances as donors", "id": "GO:0016679", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016679", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "flavonoid 3'-monooxygenase activity", "id": "GO:0016711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016711", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "vitamin D 24-hydroxylase activity", "id": "GO:0070576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070576", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "arachidonic acid monooxygenase activity", "id": "GO:0008391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008391", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "long-chain fatty acid omega-1 hydroxylase activity", "id": "GO:0120319", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120319", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "estrogen 2-hydroxylase activity", "id": "GO:0101021", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101021", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "long-chain fatty acid omega-hydroxylase activity", "id": "GO:0102033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102033", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 38, "go_terms": [ { "name": "retinol metabolic process", "id": "GO:0042572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "lipid hydroxylation", "id": "GO:0002933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002933", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "estrogen metabolic process", "id": "GO:0008210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008210", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "vitamin D metabolic process", "id": "GO:0042359", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042359", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "omega-hydroxylase P450 pathway", "id": "GO:0097267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097267", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to arsenic-containing substance", "id": "GO:0046685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046685", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "long-chain fatty acid metabolic process", "id": "GO:0001676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to lipopolysaccharide", "id": "GO:0032496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032496", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to hypoxia", "id": "GO:0001666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001666", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to food", "id": "GO:0032094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032094", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "xenobiotic metabolic process", "id": "GO:0006805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to vitamin A", "id": "GO:0033189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033189", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "9-cis-retinoic acid biosynthetic process", "id": "GO:0042904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042904", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "hydrogen peroxide biosynthetic process", "id": "GO:0050665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050665", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "positive regulation of G1/S transition of mitotic cell cycle", "id": "GO:1900087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900087", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "amine metabolic process", "id": "GO:0009308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009308", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "digestive tract development", "id": "GO:0048565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048565", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "steroid metabolic process", "id": "GO:0008202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "cellular response to organic cyclic compound", "id": "GO:0071407", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071407", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "cellular response to copper ion", "id": "GO:0071280", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071280", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "hepatocyte differentiation", "id": "GO:0070365", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070365", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to iron(III) ion", "id": "GO:0010041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010041", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to immobilization stress", "id": "GO:0035902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035902", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to hyperoxia", "id": "GO:0055093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055093", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to herbicide", "id": "GO:0009635", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009635", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "long-chain fatty acid biosynthetic process", "id": "GO:0042759", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042759", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "camera-type eye development", "id": "GO:0043010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043010", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "epoxygenase P450 pathway", "id": "GO:0019373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019373", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "maternal process involved in parturition", "id": "GO:0060137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060137", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "porphyrin-containing compound metabolic process", "id": "GO:0006778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006778", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "response to nematode", "id": "GO:0009624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009624", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "ethylene metabolic process", "id": "GO:0009692", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009692", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "coumarin metabolic process", "id": "GO:0009804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009804", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "flavonoid metabolic process", "id": "GO:0009812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009812", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "insecticide metabolic process", "id": "GO:0017143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017143", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" }, { "name": "dibenzo-p-dioxin catabolic process", "id": "GO:0019341", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019341", "evidence": [ { "database": "UniProtKB", "id": "P04798", "url": "https://www.uniprot.org/uniprot/P04798" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17149", "name": "", "equation": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11711-1", "P05182-1", "A0A8I6A0P6-1", "P10633-1", "P51538-1", "P00176-1", "P05178-1", "P10610-1", "P13107-1", "P20812-1", "P33272-1", "P51870-1", "P00185-1", "Q64581-1", "P05179-1", "P51871-1", "P04167-1", "P04800-1", "P05183-1", "P10634-1", "P11510-1", "P12938-1", "P12939-1", "P15129-1", "P15149-1", "P20814-1", "P33273-1", "P51590-1", "Q64583-1", "Q64680-1", "P04799-1", "Q64678-1", "P08683-1", "P24464-1", "D4A820-1", "A0A0G2K5K4-1", "F1LT33-1", "G3V9D2-1", "Q9QXF7-1", "A0A8I5ZZ08-1", "P05181-1", "A0A087X1C5-1", "P08684-1", "P20853-1", "P04798-1", "P05177-1", "P33261-1", "Q86W10-1", "Q16678-1", "P98187-1", "P10632-1", "P24462-1", "Q9HB55-1", "P13584-1", "Q16696-1", "Q9HCS2-1", "P33260-1", "Q02928-1", "Q08477-1", "Q9HBI6-1", "P78329-1", "P11712-1", "P24903-1", "P20815-1", "Q6V0L0-1", "P20852-1", "O09158-1", "O55071-1", "Q64459-1", "Q64481-1", "O54749-1", "P15392-1", "Q8CIM7-1", "P56654-1", "P56655-1", "P56656-1", "P12791-1", "P56593-1", "O54750-1", "Q91WL5-1", "Q91X77-1", "Q64458-1", "P00186-1", "P00184-1", "Q6XVG2-1", "Q9D816-1", "P11714-1", "P12790-1", "P24457-1", "Q9JMA7-1", "P24456-1", "Q64462-1", "Q64464-1", "Q05421-1", "Q64429-1", "D3YYZ0-1", "D3Z2W7-1", "B2RXZ2-1", "Q9WV19-1", "Q9DBX6-1", "E9Q593-1", "A2A974-1", "A6H6J2-1", "Q9EQW4-1", "B2RXA7-1" ], "evidence": [ { "id": "17149", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17149" } ] }, { "id": "37947", "name": "", "equation": "(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "D3ZKX9-1", "P04798-1", "P05177-1", "Q16678-1", "Q96SQ9-1", "Q9BYJ1-1", "P00186-1", "Q9DBX6-1", "P00184-1", "Q64429-1", "Q9WV07-1" ], "evidence": [ { "id": "37947", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/37947" } ] }, { "id": "39759", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q4V8D1-1", "Q9QXF7-1", "P04798-1", "P05177-1", "P33261-1", "P11712-1", "Q7Z449-1", "P00186-1", "P00184-1", "Q91WL5-1", "Q9CX98-1", "A2A974-1" ], "evidence": [ { "id": "39759", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39759" } ] }, { "id": "39779", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "P08683-1", "P24470-1", "P08684-1", "P51589-1", "P04798-1", "P05177-1", "P33261-1", "P10632-1", "P11712-1", "P00186-1", "P00184-1", "Q91WL5-1", "E9Q5K4-1", "A2A974-1" ], "evidence": [ { "id": "39779", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39779" } ] }, { "id": "39787", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P05182-1", "P05181-1", "P04798-1", "P33261-1", "Q08477-1", "P00184-1", "Q05421-1", "Q91WL5-1", "A2A974-1" ], "evidence": [ { "id": "39787", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39787" } ] }, { "id": "39811", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "Q9HCS2-1", "P00184-1", "A2A974-1" ], "evidence": [ { "id": "39811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39811" } ] }, { "id": "42088", "name": "", "equation": "all-trans-retinal + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinoate + 2 H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "Q9QXF7-1", "P04798-1", "P05177-1", "Q16678-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "42088", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42088" } ] }, { "id": "42092", "name": "", "equation": "all-trans-retinol + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-retinal + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P10635-1", "P08684-1", "P04798-1", "P05177-1", "Q16678-1", "P20815-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "42092", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42092" } ] }, { "id": "47204", "name": "", "equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 16alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P08684-1", "P04798-1", "P10632-1", "P24462-1", "P00184-1" ], "evidence": [ { "id": "47204", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47204" } ] }, { "id": "47208", "name": "", "equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P08684-1", "P04798-1", "P05177-1", "Q16678-1", "P11511-1", "P20813-1", "P24462-1", "P11712-1", "P20815-1", "P28649-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "47208", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47208" } ] }, { "id": "47212", "name": "", "equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 2-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P08684-1", "P04798-1", "P05177-1", "Q16678-1", "P11712-1", "P20813-1", "P24462-1", "P20815-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "47212", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47212" } ] }, { "id": "47276", "name": "", "equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "47276", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47276" } ] }, { "id": "47280", "name": "", "equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P08684-1", "P04798-1", "P05177-1", "Q16678-1", "P20815-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "47280", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47280" } ] }, { "id": "47284", "name": "", "equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "47284", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47284" } ] }, { "id": "47288", "name": "", "equation": "17beta-estradiol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxy-17beta-estradiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "47288", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47288" } ] }, { "id": "47292", "name": "", "equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 4-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P08684-1", "P04798-1", "P05177-1", "Q16678-1", "P24462-1", "P20815-1", "P00186-1", "P00184-1", "Q64429-1" ], "evidence": [ { "id": "47292", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47292" } ] }, { "id": "47308", "name": "", "equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 6alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "47308", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47308" } ] }, { "id": "47312", "name": "", "equation": "estrone + O2 + reduced [NADPH--hemoprotein reductase] = 15alpha-hydroxyestrone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "47312", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47312" } ] }, { "id": "48632", "name": "", "equation": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P04798-1", "P05177-1", "Q16678-1", "Q96SQ9-1", "P00186-1", "P00184-1", "Q9DBX6-1", "Q64429-1" ], "evidence": [ { "id": "48632", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48632" } ] }, { "id": "48636", "name": "", "equation": "(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P49430-1", "D3ZKX9-1", "Q62969-1", "P04798-1", "P05177-1", "Q16678-1", "Q96SQ9-1", "Q9BYJ1-1", "Q16647-1", "P24557-1", "P00186-1", "P00184-1", "Q9DBX6-1", "Q64429-1", "Q9WV07-1", "O35074-1", "P36423-1" ], "evidence": [ { "id": "48636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48636" } ] }, { "id": "48716", "name": "", "equation": "(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "D3ZKX9-1", "P04798-1", "P05177-1", "Q16678-1", "Q96SQ9-1", "Q9BYJ1-1", "P00186-1", "P00184-1", "Q9DBX6-1", "Q64429-1", "Q9WV07-1" ], "evidence": [ { "id": "48716", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48716" } ] }, { "id": "49856", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04799-1", "Q64678-1", "P08683-1", "P24470-1", "P10635-1", "P08684-1", "P51589-1", "P04798-1", "P05177-1", "P10632-1", "P11712-1", "Q86W10-1", "P00186-1", "P00184-1", "P56657-1" ], "evidence": [ { "id": "49856", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49856" } ] }, { "id": "49860", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "Q64678-1", "P08683-1", "P24470-1", "P08684-1", "P51589-1", "P04798-1", "P05177-1", "P33261-1", "Q16678-1", "P10632-1", "P11712-1", "P00186-1", "P00184-1", "Q64429-1", "P56657-1" ], "evidence": [ { "id": "49860", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49860" } ] }, { "id": "49880", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "Q64678-1", "P08683-1", "P24470-1", "P10635-1", "P51589-1", "P04798-1", "P33261-1", "Q16678-1", "P10632-1", "P11712-1", "P00184-1", "Q64429-1", "E9Q5K4-1" ], "evidence": [ { "id": "49880", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49880" } ] }, { "id": "49884", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "Q64678-1", "P08683-1", "P24470-1", "P10635-1", "P51589-1", "P04798-1", "P33261-1", "Q16678-1", "P11712-1", "P00184-1", "Q64429-1", "E9Q5K4-1" ], "evidence": [ { "id": "49884", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49884" } ] }, { "id": "49968", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "49968", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49968" } ] }, { "id": "49972", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH--hemoprotein reductase] = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04798-1", "P00184-1" ], "evidence": [ { "id": "49972", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49972" } ] }, { "id": "50076", "name": "", "equation": "(5Z,8Z,11Z)-eicosatrienoate + O2 + reduced [NADPH--hemoprotein reductase] = 19-hydroxy-(5Z,8Z,11Z)-eicosatrienoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P05182-1", "P05181-1", "P04798-1", "P33261-1", "P00184-1", "Q05421-1" ], "evidence": [ { "id": "50076", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50076" } ] }, { "id": "52120", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P04799-1", "P10635-1", "P08684-1", "P51589-1", "P04798-1", "P05177-1", "P33261-1", "P10632-1", "P00186-1", "P00184-1" ], "evidence": [ { "id": "52120", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52120" } ] }, { "id": "52124", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P00185-1", "P10635-1", "P08684-1", "P51589-1", "P04798-1", "P33261-1", "P10632-1", "P00184-1" ], "evidence": [ { "id": "52124", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52124" } ] }, { "id": "R-HSA-1989764", "name": "Expression of CYP1A1", "equation": "", "summary": "The CYP1A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein (van der Meer et al. 2010, Rakhshandehroo et al. 2009). The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. AHR acts as a sensor of polyaromatic chemicals, which upon activation, translocates to the nucleus and binds with the aryl hydrocarbon receptor nuclear translocator (ARNT) to transactivate target genes via binding to xenobiotic response elements (XREs) in their promoter regions. AHR targets genes of Phase I and Phase II metabolism, such as cytochrome P450 1A1 (CYP1A1) (Beischlag et al. 2008). AHR is regulated by the aryl hydrocarbon receptor repressor (AHRR, aka BHLHE77, KIAA1234) that inhibits both xenobiotic-induced and constitutively active AHR transcriptional activity in many species (Hahn et al. 2009, Haarmann-Stemmann & Abel 2006).
", "cellular_location": "endoplasmic reticulum membrane, nucleoplasm", "input_participant_list": [ "R-HSA-5649956" ], "output_participant_list": [ "R-HSA-52623" ], "enzyme_list": [ "Q15788-1", "Q92793-1", "P04798-1", "Q96RS0-1", "Q86X55-3", "Q3L8U1-1", "Q9BYK8-1" ], "evidence": [ { "id": "R-HSA-1989764", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1989764" } ] }, { "id": "R-HSA-2161795", "name": "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)", "equation": "", "summary": "Cytochrome P450s 1A1 (CYP1A1), 1A2 (CYP1A2), and 1B1 (CYP1B1) convert arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids (16-, 17-, and 18-HETEs) (Choudhary et al. 2004).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q16678-1", "P04798-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-2161795", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161795" } ] }, { "id": "R-HSA-2161814", "name": "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)", "equation": "", "summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-HETE). The CYPs and their references are as follows: CYP2C8 (Bylund et al. 1998); CYP2C9 (Bylund et al. 1998); CYP2C19 (Bylund et al. 1998); CYP4A11 (Gainer et al. 2005); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2142836" ], "enzyme_list": [ "P33261-1", "Q16678-1", "Q7Z449-1", "P04798-1", "P10632-1", "P11712-1", "Q02928-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-2161814", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161814" } ] }, { "id": "R-HSA-2161890", "name": "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)", "equation": "", "summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 5,6-epoxyeicosatrienoic acid (5,6-EET). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2J2 (Wu et al. 1996).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2142739" ], "enzyme_list": [ "P51589-1", "Q16678-1", "P04798-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-2161890", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161890" } ] }, { "id": "R-HSA-2161899", "name": "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)", "equation": "", "summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (8,9-, 11,12-, 14,15-EETs). The CYPs and their references are as follows: CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004); CYP2C8, CYP2C9 (Rifkind et al. 1995); CYP2C19 (Bylund et al. 1998, Rifkind et al. 1995); CYP2J2 (Wu et al. 1996).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P33261-1", "P51589-1", "Q16678-1", "P04798-1", "P10632-1", "P11712-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-2161899", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161899" } ] }, { "id": "R-HSA-2161940", "name": "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)", "equation": "", "summary": "Several cytochrome P450s (CYPs) convert arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). The CYPs and their references are as follows: CYP4A11 (Gainer et al. 2005, Powell 1998); CYP4F2 (Powell et al. 1998, Kikuta et al. 2002); CYP2U1 (Chuang et al. 2004); CYP1A1, CYP1A2, CYP1B1 (Choudhary et al. 2004).", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-2142780" ], "enzyme_list": [ "Q16678-1", "Q7Z449-1", "P04798-1", "P78329-1", "Q02928-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-2161940", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2161940" } ] }, { "id": "R-HSA-76472", "name": "Ethylene is oxidized to Ethylene oxide by CYP1A1", "equation": "", "summary": "A simple example of epoxidation is the oxidation of an alkene (olefin) to the epoxide (oxirane), catalysed by CYP1A1. Even the simplest of epoxides (ethylene oxide) can react with DNA and amino groups in a protein.", "cellular_location": "endoplasmic reticulum lumen, endoplasmic reticulum membrane, smooth endoplasmic reticulum", "input_participant_list": [ "R-ALL-38985" ], "output_participant_list": [ "R-ALL-38987" ], "enzyme_list": [ "P04798-1" ], "evidence": [ { "id": "R-HSA-76472", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-76472" } ] }, { "id": "R-HSA-9037761", "name": "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1", "equation": "", "summary": "Protectin D1, identified as (N)PD1 (N signifies neuroprotectin when produced in neural tissues), is a natural product derived from docosahexaenoic acid (DHA) through the actions of 15 lipoxygenase followed by enzymatic hydrolysis by an unidentified hydrolase. (N)PD1 is one of the specialized proresolving mediators (SPMs) that show potent anti inflammatory and pro resolving actions (Molfino et al. 2017, Balas & Durand 2016). (N)PD1 has been the subject of many pharmacological studies for the development of potential new anti inflammatory drugs. The 22 hydroxylated metabolite of (N)PD1 (here signified as 22 OH (N)PD1) has been shown to exhibit potent pro resolving actions by inhibiting PMN chemotaxis in vivo with mice and in vitro with human cells and decreases pro inflammatory mediator levels in inflammatory exudates. These observations were comparable to those of its precursor (N)PD1 (Tungen et al. 2014). 22 OH (N)PD1 is most likely formed by the action of CYP1 monooxygenases, just like for some other SPMs (Divanovic et al. 2013).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-9024886" ], "output_participant_list": [ "R-ALL-9037755" ], "enzyme_list": [ "P04798-1", "P05177-1" ], "evidence": [ { "id": "R-HSA-9037761", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9037761" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2142739", "participant_name": "5,6-EET [cytosol]", "crossref": [ { "id": "34450", "database": "ChEBI", "url": "" }, { "id": "HMDB0002190", "database": "HMDB Metabolite", "url": "" }, { "id": "6304", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000004655402", "database": "ZINC", "url": "" }, { "id": "000012495586", "database": "ZINC", "url": "" }, { "id": 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"activity": "", "evidence": [ { "id": "A0A8I6A0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0P6" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A0A8I6A0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0P6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A0A8I6A0P6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0P6" } ] } ] }, { "uniprot_ac": "A2A974", "gene_name": "Cyp4a12b", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A2A974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A974" } ] } ] }, { "uniprot_ac": "A6H6J2", "gene_name": "Cyp2b13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "A6H6J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6H6J2" } ] } ] }, { "uniprot_ac": "B2RXA7", "gene_name": "Cyp26c1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXA7" } ] } ] }, { "uniprot_ac": "B2RXZ2", "gene_name": "Cyp2a22", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "B2RXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXZ2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "B2RXZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RXZ2" } ] } ] }, { "uniprot_ac": "D3YYZ0", "gene_name": "Cyp3a57", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "D3YYZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYZ0" } ] } ] }, { "uniprot_ac": "D3Z2W7", "gene_name": "Cyp3a59", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "D3Z2W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z2W7" } ] } ] }, { "uniprot_ac": "D3ZKX9", "gene_name": "Aloxe3", "activity": [ { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "D3ZKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZKX9" } ] }, { "ec_number": "5.4.4.7", "activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.", "evidence": [ { "id": "D3ZKX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZKX9" } ] } ] }, { "uniprot_ac": "D4A820", "gene_name": "Cyp2s1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "D4A820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A820" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "D4A820", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A820" } ] } ] }, { "uniprot_ac": "E9Q593", "gene_name": "Cyp2b23", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "E9Q593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q593" } ] } ] }, { "uniprot_ac": "E9Q5K4", "gene_name": "Cyp2c23", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "E9Q5K4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q5K4" } ] } ] }, { "uniprot_ac": "F1LT33", "gene_name": "Cyp2b14", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "F1LT33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LT33" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "F1LT33", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LT33" } ] } ] }, { "uniprot_ac": "G3V9D2", "gene_name": "Cyp2b21", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "G3V9D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "G3V9D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9D2" } ] } ] }, { "uniprot_ac": "O09158", "gene_name": "Cyp3a25", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "O09158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09158" } ] } ] }, { "uniprot_ac": "O35074", "gene_name": "Ptgis", "activity": [ { "ec_number": "5.3.99.4", "activity": "prostaglandin H2 = prostaglandin I2.", "evidence": [ { "id": "O35074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35074" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "O35074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35074" } ] }, { "ec_number": "5.3.99.4", "activity": "", "evidence": [ { "id": "O35074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35074" } ] } ] }, { "uniprot_ac": "O54749", "gene_name": "Cyp2j5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54749", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54749" } ] } ] }, { "uniprot_ac": "O54750", "gene_name": "Cyp2j6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54750" } ] } ] }, { "uniprot_ac": "O55071", "gene_name": "Cyp2b19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "O55071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55071" } ] } ] }, { "uniprot_ac": "P00176", "gene_name": "Cyp2b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00176" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00176" } ] } ] }, { "uniprot_ac": "P00184", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00184" } ] } ] }, { "uniprot_ac": "P00185", "gene_name": "Cyp1a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00185" } ] } ] }, { "uniprot_ac": "P00186", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P00186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00186" } ] } ] }, { "uniprot_ac": "P04167", "gene_name": "Cyp2b2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04167" } ] } ] }, { "uniprot_ac": "P04798", "gene_name": "CYP1A1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04798", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04798" } ] } ] }, { "uniprot_ac": "P04799", "gene_name": "Cyp1a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P04799", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04799" } ] } ] }, { "uniprot_ac": "P04800", "gene_name": "Cyp3a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P04800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04800" } ] } ] }, { "uniprot_ac": "P05177", "gene_name": "CYP1A2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05177", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05177" } ] } ] }, { "uniprot_ac": "P05178", "gene_name": "Cyp2c6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05178", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05178" } ] } ] }, { "uniprot_ac": "P05179", "gene_name": "Cyp2c7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05179", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05179" } ] } ] }, { "uniprot_ac": "P05181", "gene_name": "CYP2E1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05181", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05181" } ] } ] }, { "uniprot_ac": "P05182", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05182" } ] } ] }, { "uniprot_ac": "P05183", "gene_name": "Cyp3a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P05183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05183" } ] } ] }, { "uniprot_ac": "P08683", "gene_name": "Cyp2c11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08683", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08683" } ] } ] }, { "uniprot_ac": "P08684", "gene_name": "CYP3A4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.55", "activity": "O2 + quinine + reduced [NADPH--hemoprotein reductase] = 3-hydroxyquinine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.56", "activity": "1,8-cineole + O2 + reduced [NADPH--hemoprotein reductase] = 2-exo-hydroxy-1,8-cineole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P08684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08684" } ] } ] }, { "uniprot_ac": "P10610", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10610", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10610" } ] } ] }, { "uniprot_ac": "P10632", "gene_name": "CYP2C8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10632", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10632" } ] } ] }, { "uniprot_ac": "P10633", "gene_name": "Cyp2d1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10633", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10633" } ] } ] }, { "uniprot_ac": "P10634", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P10634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10634" } ] } ] }, { "uniprot_ac": "P10635", "gene_name": "CYP2D6", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P10635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10635" } ] } ] }, { "uniprot_ac": "P11510", "gene_name": "Cyp2c12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11510" } ] } ] }, { "uniprot_ac": "P11511", "gene_name": "CYP19A1", "activity": [ { "ec_number": "1.14.14.14", "activity": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11511" } ] }, { "ec_number": "1.14.14.14", "activity": "", "evidence": [ { "id": "P11511", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11511" } ] } ] }, { "uniprot_ac": "P11711", "gene_name": "Cyp2a1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11711" } ] } ] }, { "uniprot_ac": "P11712", "gene_name": "CYP2C9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11712" } ] } ] }, { "uniprot_ac": "P11714", "gene_name": "Cyp2d9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P11714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11714" } ] } ] }, { "uniprot_ac": "P12790", "gene_name": "Cyp2b9", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12790" } ] } ] }, { "uniprot_ac": "P12791", "gene_name": "Cyp2b10", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12791" } ] } ] }, { "uniprot_ac": "P12938", "gene_name": "Cyp2d3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12938" } ] } ] }, { "uniprot_ac": "P12939", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P12939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12939" } ] } ] }, { "uniprot_ac": "P13107", "gene_name": "Cyp2b3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13107", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13107" } ] } ] }, { "uniprot_ac": "P13584", "gene_name": "CYP4B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P13584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13584" } ] } ] }, { "uniprot_ac": "P15129", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15129", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15129" } ] } ] }, { "uniprot_ac": "P15149", "gene_name": "Cyp2a2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15149" } ] } ] }, { "uniprot_ac": "P15392", "gene_name": "Cyp2a4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P15392", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15392" } ] } ] }, { "uniprot_ac": "P20812", "gene_name": "Cyp2a3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20812", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20812" } ] } ] }, { "uniprot_ac": "P20813", "gene_name": "CYP2B6", "activity": [ { "ec_number": "1.14.13.-", "activity": "", "evidence": [ { "id": "P20813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20813" } ] } ] }, { "uniprot_ac": "P20814", "gene_name": "Cyp2c13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20814", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20814" } ] } ] }, { "uniprot_ac": "P20815", "gene_name": "CYP3A5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20815" } ] } ] }, { "uniprot_ac": "P20852", "gene_name": "Cyp2a5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20852", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20852" } ] } ] }, { "uniprot_ac": "P20853", "gene_name": "CYP2A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P20853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20853" } ] } ] }, { "uniprot_ac": "P24456", "gene_name": "Cyp2d10", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24456" } ] } ] }, { "uniprot_ac": "P24457", "gene_name": "Cyp2d11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24457", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24457" } ] } ] }, { "uniprot_ac": "P24462", "gene_name": "CYP3A7", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24462" } ] } ] }, { "uniprot_ac": "P24464", "gene_name": "Cyp4a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24464" } ] } ] }, { "uniprot_ac": "P24470", "gene_name": "Cyp2c23", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P24470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24470" } ] } ] }, { "uniprot_ac": "P24557", "gene_name": "TBXAS1", "activity": [ { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "P24557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24557" } ] }, { "ec_number": "5.3.99.5", "activity": "", "evidence": [ { "id": "P24557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24557" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P24557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24557" } ] } ] }, { "uniprot_ac": "P24903", "gene_name": "CYP2F1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P24903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24903" } ] } ] }, { "uniprot_ac": "P28649", "gene_name": "Cyp19a1", "activity": [ { "ec_number": "1.14.14.14", "activity": "androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P28649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28649" } ] }, { "ec_number": "1.14.14.14", "activity": "", "evidence": [ { "id": "P28649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28649" } ] } ] }, { "uniprot_ac": "P33260", "gene_name": "CYP2C18", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33260" } ] } ] }, { "uniprot_ac": "P33261", "gene_name": "CYP2C19", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.51", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.52", "activity": "(4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (4S)-perillyl alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.53", "activity": "(4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.75", "activity": "fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = 4'-hydroxyfenbendazole + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33261" } ] } ] }, { "uniprot_ac": "P33272", "gene_name": "Cyp2b12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33272" } ] } ] }, { "uniprot_ac": "P33273", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P33273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33273" } ] } ] }, { "uniprot_ac": "P36423", "gene_name": "Tbxas1", "activity": [ { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P36423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36423" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "P36423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36423" } ] }, { "ec_number": "5.3.99.5", "activity": "", "evidence": [ { "id": "P36423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36423" } ] } ] }, { "uniprot_ac": "P49430", "gene_name": "Tbxas1", "activity": [ { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "P49430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49430" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "P49430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49430" } ] }, { "ec_number": "5.3.99.5", "activity": "", "evidence": [ { "id": "P49430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49430" } ] } ] }, { "uniprot_ac": "P51538", "gene_name": "Cyp3a9", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51538" } ] } ] }, { "uniprot_ac": "P51589", "gene_name": "CYP2J2", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] }, { "ec_number": "5.4.4.7", "activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] }, { "ec_number": "1.14.14.73", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] }, { "ec_number": "1.14.14.74", "activity": "albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51589" } ] } ] }, { "uniprot_ac": "P51590", "gene_name": "Cyp2j3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51590" } ] } ] }, { "uniprot_ac": "P51870", "gene_name": "Cyp4f5", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51870" } ] } ] }, { "uniprot_ac": "P51871", "gene_name": "Cyp4f6", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P51871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51871" } ] } ] }, { "uniprot_ac": "P56593", "gene_name": "Cyp2a12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56593" } ] } ] }, { "uniprot_ac": "P56654", "gene_name": "Cyp2c37", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56654", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56654" } ] } ] }, { "uniprot_ac": "P56655", "gene_name": "Cyp2c38", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56655" } ] } ] }, { "uniprot_ac": "P56656", "gene_name": "Cyp2c39", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P56656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56656" } ] } ] }, { "uniprot_ac": "P56657", "gene_name": "Cyp2c40", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "P56657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56657" } ] } ] }, { "uniprot_ac": "P78329", "gene_name": "CYP4F2", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P78329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78329" } ] } ] }, { "uniprot_ac": "P98187", "gene_name": "CYP4F8", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "P98187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P98187" } ] } ] }, { "uniprot_ac": "Q02928", "gene_name": "CYP4A11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q02928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02928" } ] } ] }, { "uniprot_ac": "Q05421", "gene_name": "Cyp2e1", "activity": [ { "ec_number": "1.14.13.n7", "activity": "4-nitrophenol + H(+) + NADPH + O2 = 4-nitrocatechol + H2O + NADP(+).", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] }, { "ec_number": "1.14.13.n7", "activity": "", "evidence": [ { "id": "Q05421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05421" } ] } ] }, { "uniprot_ac": "Q08477", "gene_name": "CYP4F3", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.94", "activity": "leukotriene B4 + O2 + reduced [NADPH--hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q08477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08477" } ] } ] }, { "uniprot_ac": "Q15788", "gene_name": "NCOA1", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q15788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15788" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q15788", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15788" } ] } ] }, { "uniprot_ac": "Q16647", "gene_name": "PTGIS", "activity": [ { "ec_number": "5.3.99.4", "activity": "prostaglandin H2 = prostaglandin I2.", "evidence": [ { "id": "Q16647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16647" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q16647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16647" } ] }, { "ec_number": "5.3.99.4", "activity": "", "evidence": [ { "id": "Q16647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16647" } ] } ] }, { "uniprot_ac": "Q16678", "gene_name": "CYP1B1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16678" } ] } ] }, { "uniprot_ac": "Q16696", "gene_name": "CYP2A13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q16696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16696" } ] } ] }, { "uniprot_ac": "Q3L8U1", "gene_name": "CHD9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q3L8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3L8U1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q3L8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3L8U1" } ] } ] }, { "uniprot_ac": "Q4V8D1", "gene_name": "Cyp2u1", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q4V8D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8D1" } ] } ] }, { "uniprot_ac": "Q62969", "gene_name": "Ptgis", "activity": [ { "ec_number": "5.3.99.4", "activity": "prostaglandin H2 = prostaglandin I2.", "evidence": [ { "id": "Q62969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62969" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q62969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62969" } ] }, { "ec_number": "5.3.99.4", "activity": "", "evidence": [ { "id": "Q62969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62969" } ] }, { "ec_number": "4.2.1.152", "activity": "", "evidence": [ { "id": "Q62969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62969" } ] } ] }, { "uniprot_ac": "Q64429", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64429" } ] } ] }, { "uniprot_ac": "Q64458", "gene_name": "Cyp2c29", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64458" } ] } ] }, { "uniprot_ac": "Q64459", "gene_name": "Cyp3a11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64459" } ] } ] }, { "uniprot_ac": "Q64462", "gene_name": "Cyp4b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64462" } ] } ] }, { "uniprot_ac": "Q64464", "gene_name": "Cyp3a13", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64464" } ] } ] }, { "uniprot_ac": "Q64481", "gene_name": "Cyp3a16", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64481" } ] } ] }, { "uniprot_ac": "Q64581", "gene_name": "Cyp3a18", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64581" } ] } ] }, { "uniprot_ac": "Q64583", "gene_name": "Cyp2b15", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64583" } ] } ] }, { "uniprot_ac": "Q64678", "gene_name": "Cyp1b1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64678" } ] } ] }, { "uniprot_ac": "Q64680", "gene_name": "Cyp2d4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q64680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64680" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q64680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64680" } ] } ] }, { "uniprot_ac": "Q6V0L0", "gene_name": "CYP26C1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6V0L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6V0L0" } ] } ] }, { "uniprot_ac": "Q6XVG2", "gene_name": "Cyp2c54", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q6XVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XVG2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q6XVG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XVG2" } ] } ] }, { "uniprot_ac": "Q7Z449", "gene_name": "CYP2U1", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q7Z449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z449" } ] }, { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q7Z449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z449" } ] } ] }, { "uniprot_ac": "Q86W10", "gene_name": "CYP4Z1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] }, { "ec_number": "1.14.14.130", "activity": "dodecanoate + O2 + reduced [NADPH--hemoprotein reductase] = 7-hydroxydodecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q86W10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86W10" } ] } ] }, { "uniprot_ac": "Q86X55", "gene_name": "CARM1", "activity": [ { "ec_number": "2.1.1.319", "activity": "L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine.", "evidence": [ { "id": "Q86X55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86X55" } ] }, { "ec_number": "2.1.1.319", "activity": "", "evidence": [ { "id": "Q86X55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86X55" } ] } ] }, { "uniprot_ac": "Q8CIM7", "gene_name": "Cyp2d26", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q8CIM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIM7" } ] } ] }, { "uniprot_ac": "Q91WL5", "gene_name": "Cyp4a12a", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q91WL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WL5" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q91WL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WL5" } ] } ] }, { "uniprot_ac": "Q91X77", "gene_name": "Cyp2c50", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q91X77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X77" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q91X77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X77" } ] } ] }, { "uniprot_ac": "Q92793", "gene_name": "CREBBP", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q92793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92793" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q92793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92793" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q92793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92793" } ] } ] }, { "uniprot_ac": "Q96RS0", "gene_name": "TGS1", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q96RS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96RS0" } ] } ] }, { "uniprot_ac": "Q96SQ9", "gene_name": "CYP2S1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q96SQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96SQ9" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q96SQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96SQ9" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "Q96SQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96SQ9" } ] } ] }, { "uniprot_ac": "Q9BYJ1", "gene_name": "ALOXE3", "activity": [ { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q9BYJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYJ1" } ] }, { "ec_number": "5.4.4.7", "activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.", "evidence": [ { "id": "Q9BYJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYJ1" } ] } ] }, { "uniprot_ac": "Q9BYK8", "gene_name": "HELZ2", "activity": [ { "ec_number": "3.1.13.1", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "Q9BYK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYK8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q9BYK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYK8" } ] }, { "ec_number": "3.1.13.1", "activity": "", "evidence": [ { "id": "Q9BYK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYK8" } ] } ] }, { "uniprot_ac": "Q9CX98", "gene_name": "Cyp2u1", "activity": [ { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9CX98", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CX98" } ] } ] }, { "uniprot_ac": "Q9D816", "gene_name": "Cyp2c55", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9D816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D816" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9D816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D816" } ] } ] }, { "uniprot_ac": "Q9DBX6", "gene_name": "Cyp2s1", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "5.3.99.5", "activity": "prostaglandin H2 = thromboxane A2.", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9DBX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBX6" } ] } ] }, { "uniprot_ac": "Q9EQW4", "gene_name": "Cyp3a44", "activity": [ { "ec_number": "1.14.14.-", "activity": "", "evidence": [ { "id": "Q9EQW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQW4" } ] } ] }, { "uniprot_ac": "Q9HB55", "gene_name": "CYP3A43", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HB55" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HB55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HB55" } ] } ] }, { "uniprot_ac": "Q9HBI6", "gene_name": "CYP4F11", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.80", "activity": "O2 + octadecanoate + reduced [NADPH--hemoprotein reductase] = 18-hydroxyoctadecanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.78", "activity": "O2 + phylloquinone + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.79", "activity": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HBI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HBI6" } ] } ] }, { "uniprot_ac": "Q9HCS2", "gene_name": "CYP4F12", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9HCS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCS2" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9HCS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCS2" } ] } ] }, { "uniprot_ac": "Q9JMA7", "gene_name": "Cyp3a41a", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9JMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMA7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9JMA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMA7" } ] } ] }, { "uniprot_ac": "Q9QXF7", "gene_name": "CYP2J4", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9QXF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXF7" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9QXF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXF7" } ] } ] }, { "uniprot_ac": "Q9WV07", "gene_name": "Aloxe3", "activity": [ { "ec_number": "4.2.1.152", "activity": "(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O.", "evidence": [ { "id": "Q9WV07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV07" } ] }, { "ec_number": "5.4.4.7", "activity": "a hydroperoxyeicosatetraenoate = a hydroxy-epoxy-eicosatetraenoate.", "evidence": [ { "id": "Q9WV07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV07" } ] } ] }, { "uniprot_ac": "Q9WV19", "gene_name": "Cyp2g1", "activity": [ { "ec_number": "1.14.14.1", "activity": "an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase].", "evidence": [ { "id": "Q9WV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV19" } ] }, { "ec_number": "1.14.14.1", "activity": "", "evidence": [ { "id": "Q9WV19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WV19" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 54, 67 ], "snv_sites": [ 54, 67, 221, 224, 246, 280, 299, 377, 393, 424 ], "glycation_sites": [], "phosphorylation_sites": [ 360 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 135 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }