{ "uniprot_canonical_ac": "P04553-1", "uniprot_ac": "P04553", "uniprot_id": "HSP1_HUMAN", "mass": { "chemical_mass": 6823.0, "monoisotopic_mass": 6823.0 }, "refseq": { "ac": "NP_002752", "name": "sperm protamine P1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" }, "gene_names": [ { "name": "PRM1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P04553", "id": "P04553" }, { "name": "CT94.1; P1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752", "id": "NP_002752" }, { "name": "PRM1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752", "id": "NP_002752" } ], "protein_names": [ { "name": "Sperm protamine P1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P04553" }, { "name": "Cysteine-rich protamine", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04553" }, { "name": "cancer/testis antigen family 94, member 1; testis specific protamine 1; cysteine-rich protamine; testicular tissue protein Li 91", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752", "id": "NP_002752" }, { "name": "sperm protamine P1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752", "id": "NP_002752" } ], "function": [ { "annotation": "Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility.", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" }, { "database": "PubMed", "id": "36217675", "url": "https://glygen.org/publication/PubMed/36217675" } ] }, { "annotation": "Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter.", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" }, { "database": "PubMed", "id": "38170186", "url": "https://glygen.org/publication/PubMed/38170186" } ] }, { "annotation": "Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions.", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" }, { "database": "PubMed", "id": "36593375", "url": "https://glygen.org/publication/PubMed/36593375" } ] }, { "annotation": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553#function" } ] }, { "annotation": "Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation.", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" }, { "database": "PubMed", "id": "37321532", "url": "https://glygen.org/publication/PubMed/37321532" } ] }, { "annotation": "Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" }, { "database": "PubMed", "id": "33440036", "url": "https://glygen.org/publication/PubMed/33440036" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "62.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "42.01", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "27.66", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "76.24", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "16.94", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "54.39", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "40.69", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "27.09", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "71.96", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "58.74", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P04553", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04553" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P04553", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04553" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P04553", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04553" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "common_name": "Human" } ], "gene": [ { "name": "PRM1", "url": "https://www.uniprot.org/uniprot/P04553", "locus": { "chromosome": "16", "start_pos": 11280841, "end_pos": 11281330, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000175646", "url": "https://www.ensembl.org/id/ENSG00000175646" } ] } } ], "crossref": [ { "id": "ENSG00000175646", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000175646", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "PRM1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRM1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "5619", "url": "https://www.ncbi.nlm.nih.gov/gene/5619", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9447", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9447", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P04553", "url": "https://www.ebi.ac.uk/intact/interactors/id:P04553*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000221", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000221", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:5619", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5619", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "182880", "url": "http://www.omim.org/entry/182880", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P04553", "url": "https://www.nextprot.org/entry/NX_P04553", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "MARYICC", "url": "https://omabrowser.org/oma/group/MARYICC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PF00260", "url": "http://pfam.xfam.org/family/PF00260", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P04553", "url": "https://pharos.nih.gov/targets/P04553", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P04553", "url": "http://purl.obolibrary.org/obo/PR_P04553", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-9821993", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821993", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P04553-1", "url": "https://www.uniprot.org/uniprot/P04553-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH", "length": 51, "header": "sp|P04553-1|HSP1_HUMAN Isoform 1 of Sperm protamine P1 OS=Homo sapiens OX=9606 GN=PRM1 PE=1 SV=2 CANONICAL=P04553-1" }, "isoforms": [ { "isoform_ac": "P04553-1", "url": "", "sequence": { "sequence": "MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH", "length": 51, "header": "sp|P04553-1|HSP1_HUMAN Isoform 1 of Sperm protamine P1 OS=Homo sapiens OX=9606 GN=PRM1 PE=1 SV=2 CANONICAL=P04553-1" }, "locus": { "chromosome": "16", "start_pos": 11281238, "end_pos": 11280995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000312511.4", "url": "https://www.ensembl.org/id/ENST00000312511.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000310515.3", "url": "https://www.ensembl.org/id/ENSP00000310515.3" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 11, "end_pos": 11, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P04553", "url": "http://phospho.elm.eu.org/byAccession/P04553.html" }, { "database": "iPTMnet", "id": "P04553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04553" }, { "database": "PubMed", "id": "8218377", "url": "https://glygen.org/publication/PubMed/8218377" } ], "site_lbl": "Ser11" }, { "start_pos": 9, "end_pos": 9, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "P04553", "url": "http://phospho.elm.eu.org/byAccession/P04553.html" }, { "database": "iPTMnet", "id": "P04553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04553" }, { "database": "PubMed", "id": "8218377", "url": "https://glygen.org/publication/PubMed/8218377" } ], "site_lbl": "Ser9" } ], "glycation": [], "keywords": [], "publication": [ { "title": "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.", "journal": "Nucleic acids research", "date": "1999", "authors": "Papoutsopoulou S, Nikolakaki E, Chalepakis G, Kruft V, Chevaillier P, Giannakouros T", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "10390541", "url": "https://glygen.org/publication/PubMed/10390541" } ] }, { "title": "Rapid evolution of male reproductive genes in the descent of man.", "journal": "Nature", "date": "2000", "authors": "Wyckoff G J, Wang W, Wu C I", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "10659848", "url": "https://glygen.org/publication/PubMed/10659848" } ] }, { "title": "Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered.", "journal": "Genomics", "date": "1990", "authors": "Domenjoud L, Nussbaum G, Adham IM, Greeske G, Engel W", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "2081589", "url": "https://glygen.org/publication/PubMed/2081589" } ] }, { "title": "Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling.", "journal": "Nucleic acids research", "date": "2012", "authors": "Okuwaki M, Sumi A, Hisaoka M, Saotome-Nakamura A, Akashi S, Nishimura Y, Nagata K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9821993", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821993" } ], "reference": [ { "type": "PubMed", "id": "22362753", "url": "https://glygen.org/publication/PubMed/22362753" } ] }, { "title": "Chromosomal localization and structure of the human P1 protamine gene.", "journal": "Genomics", "date": "1989", "authors": "Krawetz SA, Herfort MH, Hamerton JL, Pon RT, Dixon GH", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "2613245", "url": "https://glygen.org/publication/PubMed/2613245" } ] }, { "title": "Tobacco smoking and its impact on the expression level of sperm nuclear protein genes: H2BFWT, TNP1, TNP2, PRM1 and PRM2.", "journal": "Andrologia", "date": "2021", "authors": "Amor H, Zeyad A, Hammadeh ME", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" } ], "reference": [ { "type": "PubMed", "id": "33440036", "url": "https://glygen.org/publication/PubMed/33440036" } ] }, { "title": "Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2.", "journal": "Biol. Chem. Hoppe-Seyler", "date": "1986", "authors": "Ammer H, Henschen A, Lee C H", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "3527226", "url": "https://glygen.org/publication/PubMed/3527226" } ] }, { "title": "Impact of tobacco smoking in association with H2BFWT, PRM1 and PRM2 genes variants on male infertility.", "journal": "Andrologia", "date": "2022-12", "authors": "Amor Houda, Jankowski Peter Michael, Dahadhah Fatina W, Al Zoubi Mazhar Salim, Hammadeh Mohamad Eid", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" } ], "reference": [ { "type": "PubMed", "id": "36217675", "url": "https://glygen.org/publication/PubMed/36217675" } ] }, { "title": "The nucleotide sequence of a human protamine 1 cDNA.", "journal": "Nucleic Acids Res.", "date": "1987", "authors": "Lee CH, Hoyer-Fender S, Engel W", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "3658707", "url": "https://glygen.org/publication/PubMed/3658707" } ] }, { "title": "Protamine 1 as a secreted colorectal cancer-specific antigen facilitating G1/S phase transition under nutrient stress conditions.", "journal": "Cellular oncology (Dordrecht)", "date": "2023-01-03", "authors": "Ren Shengnan, Yang Dingquan, Dong Yongli, Ni Weidong, Wang Meiqi, Xing Lei, Liu Tong, Hou Wenjia, Sun Weixuan, Zhang Haolong, Yu Zhentao, Liu Yi, Cao Jingrui, Yan Hongbo, Feng Ye, Fang Xuedong, Wang Quan, Chen Fangfang", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" } ], "reference": [ { "type": "PubMed", "id": "36593375", "url": "https://glygen.org/publication/PubMed/36593375" } ] }, { "title": "Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation.", "journal": "Cancer letters", "date": "2023-07-28", "authors": "Qin Li, Dong Zizheng, Huang Caoqinglong, Liu Hao, Beebe Jenny, Subramaniyan Boopathi, Hao Yangyang, Liu Yunlong, He Zhimin, Liu Jing-Yuan, Zhang Jian-Ting", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" } ], "reference": [ { "type": "PubMed", "id": "37321532", "url": "https://glygen.org/publication/PubMed/37321532" } ] }, { "title": "Molecular and Functional Characterization of Human Sex-Determining Region on the Y Chromosome Variants Using Protamine 1 Promoter.", "journal": "DNA and cell biology", "date": "2024-01", "authors": "Pathak Deepali, Baksi Arka, Vasan S S, Dighe Rajan R", "evidence": [ { "database": "RefSeq", "id": "NP_002752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002752" } ], "reference": [ { "type": "PubMed", "id": "38170186", "url": "https://glygen.org/publication/PubMed/38170186" } ] }, { "title": "The amino acid sequence of human sperm protamine P1.", "journal": "Biosci. Rep.", "date": "1985", "authors": "McKay D J, Renaux B S, Dixon G H", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "4027356", "url": "https://glygen.org/publication/PubMed/4027356" } ] }, { "title": "Characterization of a human locus in transition.", "journal": "J. Biol. Chem.", "date": "1994", "authors": "Nelson JE, Krawetz SA", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "7983046", "url": "https://glygen.org/publication/PubMed/7983046" } ] }, { "title": "Phosphorylation of human sperm protamines HP1 and HP2: identification of phosphorylation sites.", "journal": "Biochimica et biophysica acta", "date": "1993", "authors": "Chirat F, Arkhis A, Martinage A, Jaquinod M, Chevaillier P, Sautiere P", "evidence": [ { "database": "iPTMnet", "id": "P04553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04553" } ], "reference": [ { "type": "PubMed", "id": "8218377", "url": "https://glygen.org/publication/PubMed/8218377" } ] }, { "title": "Direct sequencing of the human protamine P1 gene and application in forensic medicine.", "journal": "J. Forensic Sci.", "date": "1993", "authors": "Queralt R, de F\u00e0bregues-Boixar O, Adroer R, Gen\u00e9 M, G\u00f3mez-Catal\u00e1n J, Huguet E, Oliva R", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "reference": [ { "type": "PubMed", "id": "8263493", "url": "https://glygen.org/publication/PubMed/8263493" } ] } ], "pathway": [ { "id": "hsa:5619", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5619", "resource": "KEGG Pathway" }, { "id": "R-HSA-9821993", "name": "Replacement of protamines by nucleosomes in the male pronucleus", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821993", "resource": "Reactome", "description": "Replacement of protamines by nucleosomes in the male pronucleus" } ], "orthologs": [ { "uniprot_canonical_ac": "P02319-1", "protein_name": "Sperm protamine P1", "gene_name": "Prm1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MARYRCCRSKSRSRCRRRRRRCRRRRRRCCRRRRRRCCRRRRSYTIRCKKY", "length": 51 }, "evidence": [ { "id": "45935868", "url": "http://www.informatics.jax.org/homology/45935868", "database": "MGI" }, { "id": "P04553", "url": "https://omabrowser.org/oma/group/P04553/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P04101-1", "protein_name": "Sperm protamine P1", "gene_name": "PRM1", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MARYRCCRSHSRSRCRPRRRRCRRRRRRCCPRRRRAVCCRRYTVIRCRRC", "length": 50 }, "evidence": [ { "id": "P04553", "url": "https://omabrowser.org/oma/group/P04553/", "database": "OMA" } ], "common_name": "Pig" }, { "uniprot_canonical_ac": "P10118-1", "protein_name": "Sperm protamine P1", "gene_name": "Prm1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARYRCCRSKSRSRCRRRRRRCRRRRRRCCRRRRRRCCRRRRSYTFRCKRY", "length": 51 }, "evidence": [ { "id": "45935868", "url": "http://www.informatics.jax.org/homology/45935868", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" }, { "name": "nucleosome", "id": "GO:0000786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000786", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" }, { "name": "chromosome condensation", "id": "GO:0030261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030261", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" }, { "name": "chromosome organization", "id": "GO:0051276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051276", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" }, { "name": "sperm DNA condensation", "id": "GO:0035092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035092", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Phosphorylated by SRPK1.", "evidence": [ { "database": "UniProtKB", "id": "P04553", "url": "https://www.uniprot.org/uniprot/P04553" }, { "database": "PubMed", "id": "10390541", "url": "https://glygen.org/publication/PubMed/10390541" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 9, 11 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 16 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }