{ "uniprot_canonical_ac": "P04201-1", "uniprot_ac": "P04201", "uniprot_id": "MAS_HUMAN", "mass": { "chemical_mass": 37465.0, "monoisotopic_mass": 37465.0 }, "refseq": { "ac": "NP_002368", "name": "proto-oncogene Mas", "summary": "This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" }, "gene_names": [ { "name": "MAS1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P04201", "id": "P04201" }, { "name": "MAS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368", "id": "NP_002368" }, { "name": "MAS; MGRA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368", "id": "NP_002368" }, { "name": "MAS", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P04201", "id": "P04201" } ], "protein_names": [ { "name": "Proto-oncogene Mas", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P04201" }, { "name": "Mas-related G protein-coupled receptor A; MAS1 oncogene", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368", "id": "NP_002368" }, { "name": "proto-oncogene Mas", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368", "id": "NP_002368" } ], "function": [ { "annotation": "Activation of Mas during myocardial infarction contributes to ischemia-reperfusion injury and suggest that inhibition of Mas-G(q) signaling may provide a new therapeutic strategy directed at cardioprotection.", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" }, { "database": "PubMed", "id": "22003054", "url": "https://glygen.org/publication/PubMed/22003054" } ] }, { "annotation": "Mas receptor endocytosis and signaling in health and disease.", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" }, { "database": "PubMed", "id": "36631200", "url": "https://glygen.org/publication/PubMed/36631200" } ] }, { "annotation": "Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" }, { "database": "PubMed", "id": "35328506", "url": "https://glygen.org/publication/PubMed/35328506" } ] }, { "annotation": "Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201#function" }, { "database": "PubMed", "id": "16611642", "url": "https://glygen.org/publication/PubMed/16611642" }, { "database": "PubMed", "id": "15809376", "url": "https://glygen.org/publication/PubMed/15809376" } ] }, { "annotation": "Sex Difference in MasR Expression and Functions in the Renal System. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" }, { "database": "PubMed", "id": "36148474", "url": "https://glygen.org/publication/PubMed/36148474" } ] }, { "annotation": "The function of the ACE2/Ang(1-7)/Mas receptor axis of the renin-angiotensin system in myocardial ischemia reperfusion injury.", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" }, { "database": "PubMed", "id": "35363333", "url": "https://glygen.org/publication/PubMed/35363333" } ] }, { "annotation": "This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1353685172", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1353685172" }, { "id": "rs1353685172", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1353685172" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 116, "end_pos": 116, "sequence_org": "Y", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (YNT->NNT).", "chr_id": "6", "chr_pos": "159907301", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "Y116", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs138263796", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138263796" }, { "id": "rs138263796", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138263796" }, { "id": "rs138263796", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs138263796#frequency_tab" }, { "id": "rs138263796", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs138263796" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 219, "end_pos": 219, "sequence_org": "W", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTW->NTS).", "chr_id": "6", "chr_pos": "159907611", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "W219", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs768348575", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768348575" }, { "id": "rs768348575", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768348575" }, { "id": "rs768348575", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768348575" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 24, "end_pos": 24, "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAS->NAL).", "chr_id": "6", "chr_pos": "159907026", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S24", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P04201", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04201" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 2, "end_pos": 2, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "6", "chr_pos": "159906959", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D2", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1338780580", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1338780580" }, { "id": "rs1338780580", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1338780580#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 317, "end_pos": 317, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NCN->NCS).", "chr_id": "6", "chr_pos": "159907905", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N317", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1583214984", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1583214984" }, { "id": "rs1583214984", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1583214984" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 52, "end_pos": 52, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGI->NGT).", "chr_id": "6", "chr_pos": "159907110", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I52", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1359535812", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1359535812" }, { "id": "rs1359535812", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1359535812" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 5, "end_pos": 5, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->SVT).", "chr_id": "6", "chr_pos": "159906969", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N5", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1287750706", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1287750706" }, { "id": "rs1287750706", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1287750706" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 7, "end_pos": 7, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->NVI).", "chr_id": "6", "chr_pos": "159906975", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T7", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 138, "end_pos": 138, "sequence_org": "I", "sequence_mut": "D", "comment": "Fails to activate GNA11.", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" }, { "database": "PubMed", "id": "16611642", "url": "https://glygen.org/publication/PubMed/16611642" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "26.13", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "41.27", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "42.06", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "17.43", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "43.24", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "33.71", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "36.49", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "37.88", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "40.38", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "38.49", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000130368", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000130368" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P04201", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04201" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": 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"MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P04201", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04201" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04201" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"categories": [ "Protein Classification" ] }, { "id": "CHEMBL3559701", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3559701", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "MAS1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MAS1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "4142", "url": "https://www.ncbi.nlm.nih.gov/gene/4142", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "6899", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6899", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P04201", "url": "https://www.ebi.ac.uk/intact/interactors/id:P04201*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000820", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000820", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4142", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4142", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "165180", "url": "http://www.omim.org/entry/165180", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P04201", "url": "https://www.nextprot.org/entry/NX_P04201", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "P04201", "url": "https://oglcnac.org/atlas/detail/P04201", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "DGNHCQA", "url": "https://omabrowser.org/oma/group/DGNHCQA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5320834at2759", "url": "http://www.orthodb.org/?query=5320834at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11334", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11334", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11334:SF61", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11334:SF61", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "http://pfam.xfam.org/family/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P04201", "url": "https://pharos.nih.gov/targets/P04201", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_P04201", "url": "http://purl.obolibrary.org/obo/PR_P04201", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P04201-1", "url": "https://www.uniprot.org/uniprot/P04201-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV", "length": 325, "header": "sp|P04201-1|MAS_HUMAN Isoform 1 of Proto-oncogene Mas OS=Homo sapiens OX=9606 GN=MAS1 PE=1 SV=1 CANONICAL=P04201-1" }, "isoforms": [ { "isoform_ac": "P04201-1", "url": "", "sequence": { "sequence": "MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV", "length": 325, "header": "sp|P04201-1|MAS_HUMAN Isoform 1 of Proto-oncogene Mas OS=Homo sapiens OX=9606 GN=MAS1 PE=1 SV=1 CANONICAL=P04201-1" }, "locus": { "chromosome": "6", "start_pos": 159907930, "end_pos": 159906956, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000252660.5", "url": "https://www.ensembl.org/id/ENST00000252660.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000252660.4", "url": "https://www.ensembl.org/id/ENSP00000252660.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 16, "start_aa": "Asn", "end_pos": 16, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn16", "evidence": [ { "id": "P04201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04201#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 223, "start_aa": "Ser", "end_pos": 223, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser223", "evidence": [ { "id": "P04201", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/P04201" }, { "id": "30620550", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 22, "start_aa": "Asn", "end_pos": 22, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn22", "evidence": [ { "id": "P04201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04201#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 5, "start_aa": "Asn", "end_pos": 5, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn5", "evidence": [ { "id": "P04201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04201#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.", "journal": "Circulation", "date": "2005-04-12", "authors": "Kostenis Evi, Milligan Graeme, Christopoulos Arthur, Sanchez-Ferrer Carlos F, Heringer-Walther Silvia, Sexton Patrick M, Gembardt Florian, Kellett Elaine, Martini Lene, Vanderheyden Patrick, Schultheiss Heinz-Peter, Walther Thomas", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "reference": [ { "type": "PubMed", "id": "15809376", "url": "https://glygen.org/publication/PubMed/15809376" } ] }, { "title": "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Canals M, Jenkins L, Kellett E, Milligan G", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "reference": [ { "type": "PubMed", "id": "16611642", "url": "https://glygen.org/publication/PubMed/16611642" } ] }, { "title": "Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection.", "journal": "American journal of physiology. Heart and circulatory physiology", "date": "2012", "authors": "Zhang T, Li Z, Dang H, Chen R, Liaw C, Tran TA, Boatman PD, Connolly DT, Adams JW", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" } ], "reference": [ { "type": "PubMed", "id": "22003054", "url": "https://glygen.org/publication/PubMed/22003054" } ] }, { "title": "G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.", "journal": "Biochemistry", "date": "2015", "authors": "Tirupula KC, Ithychanda SS, Mohan ML, Naga Prasad SV, Qin J, Karnik SS", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "reference": [ { "type": "PubMed", "id": "26460884", "url": "https://glygen.org/publication/PubMed/26460884" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "P04201", "url": "https://oglcnac.org/atlas/detail/P04201" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "The mas oncogene encodes an angiotensin receptor.", "journal": "Nature", "date": "1988", "authors": "Jackson T R, Blair L A, Marshall J, Goedert M, Hanley M R", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "reference": [ { "type": "PubMed", "id": "3419518", "url": "https://glygen.org/publication/PubMed/3419518" } ] }, { "title": "Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome.", "journal": "International journal of molecular sciences", "date": "2022", "authors": "Che Mohd Nassir CMN, Zolkefley MKI, Ramli MD, Norman HH, Abdul Hamid H, Mustapha M", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" } ], "reference": [ { "type": "PubMed", "id": "35328506", "url": "https://glygen.org/publication/PubMed/35328506" } ] }, { "title": "The function of the ACE2/Ang(1-7)/Mas receptor axis of the renin-angiotensin system in myocardial ischemia reperfusion injury.", "journal": "European review for medical and pharmacological sciences", "date": "2022", "authors": "Xie JX, Hu J, Cheng J, Liu C, Wei X", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" } ], "reference": [ { "type": "PubMed", "id": "35363333", "url": "https://glygen.org/publication/PubMed/35363333" } ] }, { "title": "Sex Difference in MasR Expression and Functions in the Renal System.", "journal": "Journal of the renin-angiotensin-aldosterone system : JRAAS", "date": "2022", "authors": "Choopani S, Nematbakhsh M", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" } ], "reference": [ { "type": "PubMed", "id": "36148474", "url": "https://glygen.org/publication/PubMed/36148474" } ] }, { "title": "Mas receptor endocytosis and signaling in health and disease.", "journal": "Progress in molecular biology and translational science", "date": "2023", "authors": "Rukavina Mikusic Natalia L, Gironacci Mariela M", "evidence": [ { "database": "RefSeq", "id": "NP_002368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002368" } ], "reference": [ { "type": "PubMed", "id": "36631200", "url": "https://glygen.org/publication/PubMed/36631200" } ] }, { "title": "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.", "journal": "Cell", "date": "1986", "authors": "Young D, Waitches G, Birchmeier C, Fasano O, Wigler M", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "reference": [ { "type": "PubMed", "id": "3708691", "url": "https://glygen.org/publication/PubMed/3708691" } ] } ], "pathway": [ { "id": "hsa:4142", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4142", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P12526-1", "protein_name": "Proto-oncogene Mas", "gene_name": "Mas1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSTFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV", "length": 324 }, "evidence": [ { "id": "45934553", "url": "http://www.informatics.jax.org/homology/45934553", "database": "MGI" }, { "id": "P04201", "url": "https://omabrowser.org/oma/group/P04201/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P30554-1", "protein_name": "Proto-oncogene Mas", "gene_name": "Mas1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDQSNMTSLAEEKAMNTSSRNASLGSSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHHYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSRSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSAFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV", "length": 324 }, "evidence": [ { "id": "45934553", "url": "http://www.informatics.jax.org/homology/45934553", "database": "MGI" }, { "id": "P04201", "url": "https://omabrowser.org/oma/group/P04201/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "G protein-coupled receptor activity", "id": "GO:0004930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "angiotensin type II receptor activity", "id": "GO:0004945", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004945", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "peptide binding", "id": "GO:0042277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042277", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "angiotensin receptor activity", "id": "GO:0001595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001595", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "G protein-coupled receptor signaling pathway", "id": "GO:0007186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007186", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "negative regulation of protein phosphorylation", "id": "GO:0001933", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001933", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "hippocampus development", "id": "GO:0021766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021766", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "male gonad development", "id": "GO:0008584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008584", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": 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"https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "positive regulation of DNA replication", "id": "GO:0045740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045740", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "response to gonadotropin", "id": "GO:0034698", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034698", "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprot/P04201" } ], "pmid": "" }, { "name": "positive regulation of inositol phosphate biosynthetic process", "id": "GO:0060732", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060732", "evidence": [ { "database": "UniProtKB", "id": 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