{ "uniprot_canonical_ac": "P04180-1", "uniprot_ac": "P04180", "uniprot_id": "LCAT_HUMAN", "mass": { "chemical_mass": 49578.0, "monoisotopic_mass": 49578.0 }, "refseq": { "ac": "NP_000220", "name": "phosphatidylcholine-sterol acyltransferase precursor", "summary": "This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" }, "gene_names": [ { "name": "LCAT", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P04180", "id": "P04180" }, { "name": "LCAT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220", "id": "NP_000220" } ], "protein_names": [ { "name": "Phosphatidylcholine-sterol acyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P04180" }, { "name": "1-alkyl-2-acetylglycerophosphocholine esterase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "2.3.1.43", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "3.1.1.47", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "Lecithin-cholesterol acyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "PAF acetylhydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "Phospholipid-cholesterol acyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "Platelet-activating factor acetylhydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P04180" }, { "name": "phosphatidylcholine-sterol acyltransferase precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220", "id": "NP_000220" }, { "name": "phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase; phosphatidylcholine--sterol O-acyltransferase; testicular secretory protein Li 24; PAF acetylhydrolase; platelet-activating factor acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220", "id": "NP_000220" } ], "function": [ { "annotation": "Altered HDL proteome predicts incident CVD in chronic kidney disease patients.", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" }, { "database": "PubMed", "id": "34634315", "url": "https://glygen.org/publication/PubMed/34634315" } ] }, { "annotation": "Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755).", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180#function" }, { "database": "PubMed", "id": "10329423", "url": "https://glygen.org/publication/PubMed/10329423" }, { "database": "PubMed", "id": "8820107", "url": "https://glygen.org/publication/PubMed/8820107" }, { "database": "PubMed", "id": "14636062", "url": "https://glygen.org/publication/PubMed/14636062" }, { "database": "PubMed", "id": "10722751", "url": "https://glygen.org/publication/PubMed/10722751" }, { "database": "PubMed", "id": "12354767", "url": "https://glygen.org/publication/PubMed/12354767" }, { "database": "PubMed", "id": "26195816", "url": "https://glygen.org/publication/PubMed/26195816" }, { "database": "PubMed", "id": "24620755", "url": "https://glygen.org/publication/PubMed/24620755" }, { "database": "PubMed", "id": "19065001", "url": "https://glygen.org/publication/PubMed/19065001" }, { "database": "PubMed", "id": "8016111", "url": "https://glygen.org/publication/PubMed/8016111" } ] }, { "annotation": "Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" }, { "database": "PubMed", "id": "33298249", "url": "https://glygen.org/publication/PubMed/33298249" } ] }, { "annotation": "LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" }, { "database": "PubMed", "id": "34256778", "url": "https://glygen.org/publication/PubMed/34256778" } ] }, { "annotation": "Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" }, { "database": "PubMed", "id": "35598637", "url": "https://glygen.org/publication/PubMed/35598637" } ] }, { "annotation": "Rapidly progressive renal failure to reveal LCAT deficiency in an Algerian family.", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" }, { "database": "PubMed", "id": "36420900", "url": "https://glygen.org/publication/PubMed/36420900" } ] }, { "annotation": "This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" } ] } ], "disease": [ { "disease_id": "DOID:1391", "recommended_name": { "id": "DOID:1391", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1391", "name": "Norum disease", "description": "" }, "synonyms": [ { "id": "DOID:1391", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1391", "name": "lecithin acyltransferase deficiency", "description": "" }, { "id": "DOID:1391", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1391", "name": "LECITHIN CHOLESTEROL ACYLTRANSFERASE DEFICIENCY", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "Norum disease", "description": "A form of lecithin-cholesterol acyltransferase deficiency (LCAT) characterized clinically by corneal opacities, hemolytic anemia, and renal failure, and biochemically by severely decreased HDL cholesterol and complete deficiency of the LCAT enzyme." }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "FLD", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "Norum disease", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "complete LCAT deficiency", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "lecithin acyltransferase deficiency", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "lecithin:cholesterol acyltransferase deficiency", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "LCAT deficiency", "description": "" }, { "id": "MONDO:0009515", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009515", "name": "familial LCAT deficiency", "description": "" }, { "id": "MIM:245900", "resource": "MIM", "url": "https://www.omim.org/entry/245900", "name": "Lecithin-cholesterol acyltransferase deficiency", "description": "Lecithin-cholesterol acyltransferase deficiency" } ], "evidence": [ { "id": "245900", "database": "MIM", "url": "https://www.omim.org/entry/245900" } ] }, { "disease_id": "MONDO:0007620", "recommended_name": { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "fish eye disease", "description": "Fish eye disease (FED) is a form of genetic LCAT (lecithin-cholesterol acyltransferase) deficiency characterized clinically by corneal opacifications, and biochemically by significantly reduced HDL cholesterol and partial LCAT enzyme deficiency." }, "synonyms": [ { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "fed", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "fish eye disease", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "partial LCAT deficiency", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "LCATA deficiency", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "alpha-LCAT deficiency", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "alpha-lecithin cholesterol acyltransferase deficiency", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "alpha-lecithin:cholesterol acyltransferase deficiency", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "dyslipoproteinemic corneal dystrophy", "description": "" }, { "id": "MONDO:0007620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007620", "name": "fish-eye disease", "description": "" }, { "id": "MIM:136120", "resource": "MIM", "url": "https://www.omim.org/entry/136120", "name": "Fish-eye disease", "description": "Fish-eye disease" } ], "evidence": [ { "id": "136120", "database": "MIM", "url": "https://www.omim.org/entry/136120" } ] } ], "snv": [ { "evidence": [ { "id": "rs538148718", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs538148718" }, { "id": "rs538148718", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs538148718" }, { "id": "rs538148718", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs538148718#frequency_tab" }, { "id": "rs538148718", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs538148718" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 101, "end_pos": 101, "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DNT->NNT).", "chr_id": "16", "chr_pos": "67943066", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D101", "keywords": [ "ebi", "somatic" ] }, { "evidence": [ { "id": "rs761902457", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761902457" }, { "id": "rs761902457", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761902457" }, { "id": "rs761902457", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs761902457" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 108, "end_pos": 108, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRS->SRS).", "chr_id": "16", "chr_pos": "67942965", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N108", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs763366383", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763366383" }, { "id": "rs763366383", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763366383" }, { "id": "rs763366383", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763366383" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 298, "end_pos": 298, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->NYR).", "chr_id": "16", "chr_pos": "67940334", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T298", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1349470729", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1349470729" }, { "id": "rs1349470729", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1349470729#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 35, "end_pos": 35, "sequence_org": "H", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HTT->NTT).", "chr_id": "16", "chr_pos": "67943999", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "H35", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1598202334", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1598202334" }, { "id": "rs1598202334", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1598202334" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 408, "end_pos": 408, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->TLT).", "chr_id": "16", "chr_pos": "67940004", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N408", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1343203166", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1343203166" }, { "id": "rs1343203166", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1343203166#frequency_tab" }, { "id": "rs1343203166", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1343203166" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 409, "end_pos": 409, "sequence_org": "L", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NPT).", "chr_id": "16", "chr_pos": "67940001", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L409", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs763505015", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763505015" }, { "id": "rs763505015", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763505015" }, { "id": "rs763505015", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763505015" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 431, "end_pos": 431, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "16", "chr_pos": "67939935", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T431", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs924584817", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs924584817" }, { "id": "rs924584817", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs924584817#frequency_tab" }, { "id": "rs924584817", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs924584817" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 433, "end_pos": 433, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->N).", "chr_id": "16", "chr_pos": "67939929", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S433", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs771517943", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771517943" }, { "id": "rs771517943", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771517943" }, { "id": "rs771517943", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs771517943#frequency_tab" }, { "id": "rs771517943", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs771517943" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 44, "end_pos": 44, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NHT->SHT).", "chr_id": "16", "chr_pos": "67942941", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N44", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1433630587", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1433630587" }, { "id": "rs1433630587", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1433630587" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 46, "end_pos": 46, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NHT->NHI).", "chr_id": "16", "chr_pos": "67943965", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T46", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 173, "end_pos": 173, "sequence_org": "E", "sequence_mut": "A", "comment": "Increased activity towards PAPC. Increased PAPC/POPC activity ratio.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" }, { "database": "PubMed", "id": "14636062", "url": "https://glygen.org/publication/PubMed/14636062" } ] }, { "start_pos": 173, "end_pos": 173, "sequence_org": "E", "sequence_mut": "D", "comment": "Little change in enzyme specific activity nor in PAPC/POPC activity ratio.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" }, { "database": "PubMed", "id": "14636062", "url": "https://glygen.org/publication/PubMed/14636062" } ] }, { "start_pos": 173, "end_pos": 173, "sequence_org": "E", "sequence_mut": "K", "comment": "Decreased enzyme specific activity. Increased PAPC/POPC activity ratio.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" }, { "database": "PubMed", "id": "14636062", "url": "https://glygen.org/publication/PubMed/14636062" } ] }, { "start_pos": 173, "end_pos": 173, "sequence_org": "E", "sequence_mut": "L", "comment": "Increased activity towards PAPC. Increased PAPC/POPC activity ratio.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" }, { "database": "PubMed", "id": "14636062", "url": "https://glygen.org/publication/PubMed/14636062" } ] }, { "start_pos": 173, "end_pos": 173, "sequence_org": "E", "sequence_mut": "Q", "comment": "Decreased enzyme specific activity. Increased PAPC/POPC activity ratio.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" }, { "database": "PubMed", "id": "14636062", "url": "https://glygen.org/publication/PubMed/14636062" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "72.85", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000213398", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000213398" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "52.95", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000213398", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000213398" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": 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"database": "Bgee", "id": "ENSG00000213398", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000213398" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000213398", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000213398" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "81.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000213398", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000213398" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "93.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000213398", "url": 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"https://www.ensembl.org/id/ENSP00000459014.1" } ] } }, { "isoform_ac": "I3L215-1", "url": "", "sequence": { "sequence": "SPRPGRTALLMASSLLGLPGVAPSSPCWSWPQECLCPGMCFTEDGSARARARPPEAPPALP", "length": 61, "header": "tr|I3L215-1|I3L215_HUMAN Computationally mapped isoform of Lecithin-cholesterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=4 SV=1 CANONICAL=P04180-1" }, "locus": { "chromosome": "16", "start_pos": 67942458, "end_pos": 67941956, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000570396.1", "url": "https://www.ensembl.org/id/ENST00000570396.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000459291.1", "url": "https://www.ensembl.org/id/ENSP00000459291.1" } ] } }, { "isoform_ac": "I3L3R0-1", "url": "", "sequence": { "sequence": "MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILARSQAGQTRCGELDVLPQDRGLLHHLAGSQHVPTPWGRLLDR", "length": 93, "header": "tr|I3L3R0-1|I3L3R0_HUMAN Computationally mapped isoform of Lecithin-cholesterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=4 SV=1 CANONICAL=P04180-1" }, "locus": { "chromosome": "16", "start_pos": 67944101, "end_pos": 67943065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000575467.5", "url": "https://www.ensembl.org/id/ENST00000575467.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000460653.1", "url": "https://www.ensembl.org/id/ENSP00000460653.1" } ] } }, { "isoform_ac": "J3QKT0-1", "url": "", "sequence": { "sequence": "VQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASETGSHCIA", "length": 138, "header": "tr|J3QKT0-1|LCAT_HUMAN Computationally mapped isoform of Phosphatidylcholine-sterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=1 SV=1 CANONICAL=P04180-1" }, "locus": { "chromosome": "16", "start_pos": 67942930, "end_pos": 67940809, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000573538.5", "url": "https://www.ensembl.org/id/ENST00000573538.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000463220.1", "url": "https://www.ensembl.org/id/ENSP00000463220.1" } ] } }, { "isoform_ac": "J3QSE5-1", "url": "", "sequence": { "sequence": "MCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAG", "length": 255, "header": "tr|J3QSE5-1|LCAT_HUMAN Computationally mapped isoform of Phosphatidylcholine-sterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=1 SV=1 CANONICAL=P04180-1" }, "locus": { "chromosome": "16", "start_pos": 67943150, "end_pos": 67940246, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000570980.1", "url": "https://www.ensembl.org/id/ENST00000570980.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000464651.1", "url": "https://www.ensembl.org/id/ENSP00000464651.1" } ] } }, { "isoform_ac": "P04180-1", "url": "", "sequence": { "sequence": "MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE", "length": 440, "header": "sp|P04180-1|LCAT_HUMAN Isoform 1 of Phosphatidylcholine-sterol acyltransferase OS=Homo sapiens OX=9606 GN=LCAT PE=1 SV=1 CANONICAL=P04180-1" }, "locus": { "chromosome": "16", "start_pos": 67944101, "end_pos": 67939907, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000264005.10", "url": "https://www.ensembl.org/id/ENST00000264005.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000264005.5", "url": "https://www.ensembl.org/id/ENSP00000264005.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine Complex", "start_pos": 108, "start_aa": "Asn", "end_pos": 108, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn108", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180#ptm_processing" }, { "id": "7613477", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7613477" }, { "id": "26195816", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26195816" }, { "id": "4X96", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4X96" }, { "id": "4XWG", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4XWG" }, { "id": "4XX1", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4XX1" }, { "id": "5BV7", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5BV7" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G22310AV", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G48414YA", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G66760KM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G81263BG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine Complex", "start_pos": 296, "start_aa": "Asn", "end_pos": 296, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn296", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180#ptm_processing" }, { "id": "16335952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16335952" }, { "id": "7613477", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7613477" }, { "id": "26195816", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26195816" }, { "id": "4X96", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4X96" }, { "id": "4XWG", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4XWG" }, { "id": "4XX1", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4XX1" }, { "id": "5BV7", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5BV7" }, { "id": "5TXF", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5TXF" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine Complex", "start_pos": 408, "start_aa": "Asn", "end_pos": 408, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn408", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180#ptm_processing" }, { "id": "7613477", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7613477" }, { "id": "26195816", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26195816" }, { "id": "4X96", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4X96" }, { "id": "4XWG", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4XWG" }, { "id": "4XX1", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/4XX1" }, { "id": "5BV7", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5BV7" }, { "id": "5TXF", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/5TXF" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "QGPPASPTASPEPPPPE", "relation": "attached", "comment": "", "start_pos": 424, "start_aa": "Gln", "end_pos": 440, "end_aa": "Glu", "evidence": [ { "id": "P04180", "database": "UniCarbKB", "url": "" }, { "id": "28035807", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28035807" }, { "id": "10.1021/acs.analchem.6b02887", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.6b02887" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "reported", "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine O-GalNAcylation", "start_pos": 431, "start_aa": "Thr", "end_pos": 431, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr431", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180#ptm_processing" }, { "id": "7613477", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7613477" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GalNAc...) serine O-GalNAcylation", "start_pos": 433, "start_aa": "Ser", "end_pos": 433, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser433", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180#ptm_processing" }, { "id": "7613477", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7613477" } ] }, { "glytoucan_ac": "G33791AF", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 44, "start_aa": "Asn", "end_pos": 44, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn44", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "Complex", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) (complex) asparagine Complex", "start_pos": 44, "start_aa": "Asn", "end_pos": 44, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn44", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180#ptm_processing" }, { "id": "16335952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16335952" }, { "id": "7613477", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7613477" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "glytoucan_ac": "G20425TQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "9555945", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9555945" } ] }, { "glytoucan_ac": "G22388FD", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "9555945", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9555945" } ] }, { "glytoucan_ac": "G23863VK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "9555945", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9555945" } ] }, { "glytoucan_ac": "G29857RC", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "9555945", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9555945" } ] }, { "glytoucan_ac": "G36191CD", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "9555945", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9555945" } ] }, { "glytoucan_ac": "G50045TK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "495", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/495" }, { "id": "9555945", 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Chem.", "date": "1987", "authors": "Yang C Y, Manoogian D, Pao Q, Lee F S, Knapp R D, Gotto A M, Pownall H J", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "2880847", "url": "https://glygen.org/publication/PubMed/2880847" } ] }, { "title": "Large-scale intact glycopeptide identification by Mascot database search.", "journal": "Scientific reports", "date": "2018", "authors": "Bollineni RC, Koehler CJ, Gislefoss RE, Anonsen JH, Thiede B", "evidence": [ { "database": "GlyConnect", "id": "495", "url": "https://glyconnect.expasy.org/browser/proteins/495" } ], "reference": [ { "type": "PubMed", "id": "29391424", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "title": "Identification of the active-site serine in human lecithin: cholesterol acyltransferase.", "journal": "Archives of biochemistry and biophysics", "date": "1988", "authors": "Farooqui JZ, Wohl RC, Kezdy FJ, Scanu AM", "evidence": [ { "database": "iPTMnet", "id": "P04180", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04180" } ], "reference": [ { "type": "PubMed", "id": "3128170", "url": "https://glygen.org/publication/PubMed/3128170" } ] }, { "title": "Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.", "journal": "BMB reports", "date": "2020", "authors": "Park HM, Kim H, Kim DW, Yoon JH, Kim BG, Cho JY", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" } ], "reference": [ { "type": "PubMed", "id": "33298249", "url": "https://glygen.org/publication/PubMed/33298249" } ] }, { "title": "LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred.", "journal": "Lipids in health and disease", "date": "2021", "authors": "Mehta R, Elias-Lopez D, Martagon AJ, Perez-Mendez OA, Sanchez MLO, Segura Y, Tusie MT, Aguilar-Salinas CA", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" } ], "reference": [ { "type": "PubMed", "id": "34256778", "url": "https://glygen.org/publication/PubMed/34256778" } ] }, { "title": "Cloning and expression of human lecithin-cholesterol acyltransferase cDNA.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1986", "authors": "McLean J, Fielding C, Drayna D, Dieplinger H, Baer B, Kohr W, Henzel W, Lawn R", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "3458198", "url": "https://glygen.org/publication/PubMed/3458198" } ] }, { "title": "Altered HDL proteome predicts incident CVD in chronic kidney disease patients.", "journal": "Journal of lipid research", "date": "2021", "authors": "Shao B, Mathew AV, Thornock C, Pennathur S", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" } ], "reference": [ { "type": "PubMed", "id": "34634315", "url": "https://glygen.org/publication/PubMed/34634315" } ] }, { "title": "Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans.", "journal": "Journal of lipid research", "date": "2022", "authors": "Pavanello C, Ossoli A, Strazzella A, Rise P, Veglia F, Lhomme M, Parini P, Calabresi L", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" } ], "reference": [ { "type": "PubMed", "id": "35598637", "url": "https://glygen.org/publication/PubMed/35598637" } ] }, { "title": "Rapidly progressive renal failure to reveal LCAT deficiency in an Algerian family.", "journal": "Clinical nephrology", "date": "2022-11-24", "authors": "Khellaf Ghalia, Benziane Ali, Kaci Louiza, Missoum Soumia, Lahmar Mourad, Benabadji Mohamed", "evidence": [ { "database": "RefSeq", "id": "NP_000220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000220" } ], "reference": [ { "type": "PubMed", "id": "36420900", "url": "https://glygen.org/publication/PubMed/36420900" } ] }, { "title": "Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression.", "journal": "Nucleic Acids Res.", "date": "1986", "authors": "McLean J, Wion K, Drayna D, Fielding C, Lawn R", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "3797244", "url": "https://glygen.org/publication/PubMed/3797244" } ] }, { "title": "A protein cofactor of lecithin:cholesterol acyltransferase.", "journal": "Biochemical and biophysical research communications", "date": "1972", "authors": "Fielding CJ, Shore VG, Fielding PE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8964058" } ], "reference": [ { "type": "PubMed", "id": "4335615", "url": "https://glygen.org/publication/PubMed/4335615" } ] }, { "title": "Lecithin: cholesterol acyltransferase: effects of substrate composition upon enzyme activity.", "journal": "Biochimica et biophysica acta", "date": "1972", "authors": "Fielding CJ, Shore VG, Fielding PE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8964058", "url": 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Six newly identified defective alleles further contribute to the structural heterogeneity in this disease.", "journal": "The Journal of clinical investigation", "date": "1993", "authors": "Funke H, von Eckardstein A, Pritchard PH, Hornby AE, Wiebusch H, Motti C, Hayden MR, Dachet C, Jacotot B, Gerdes U, et al.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "8432868", "url": "https://glygen.org/publication/PubMed/8432868" } ] }, { "title": "Two novel molecular defects in the LCAT gene are associated with fish eye disease.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "1996", "authors": "Kuivenhoven JA, Stalenhoef AF, Hill JS, Demacker PN, Errami A, Kastelein JJ, Pritchard PH", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "8620346", "url": "https://glygen.org/publication/PubMed/8620346" } ] }, { "title": "Complete deficiency of plasma lecithin-cholesterol acyltransferase (LCAT) activity due to a novel homozygous mutation (Gly-30-Ser) in the LCAT gene.", "journal": "Human mutation", "date": "1996", "authors": "Owen JS, Wiebusch H, Cullen P, Watts GF, Lima VL, Funke H, Assmann G", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "8807342", "url": "https://glygen.org/publication/PubMed/8807342" } ] }, { "title": "Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates.", "journal": "Journal of lipid research", "date": "1996-01", "authors": "Subbaiah P V, Liu M", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "8820107", "url": "https://glygen.org/publication/PubMed/8820107" } ] }, { "title": "A novel missense mutation (Asn5-->Ile) in lecithin: cholesterol acyltransferase (LCAT) gene in a Japanese patient with LCAT deficiency.", "journal": "International journal of clinical & laboratory research", "date": "1996", "authors": "Okubo M, Aoyama Y, Shio H, Albers JJ, Murase T", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "reference": [ { "type": "PubMed", "id": "9007616", "url": "https://glygen.org/publication/PubMed/9007616" } ] }, { "title": "Molecular basis of fish-eye disease in a patient from Spain. 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region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "high-density lipoprotein particle", "id": "GO:0034364", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034364", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "O-acyltransferase activity", "id": "GO:0008374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008374", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "sterol esterase activity", "id": "GO:0004771", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004771", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "platelet-activating factor acetyltransferase activity", "id": "GO:0047179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047179", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "apolipoprotein A-I binding", "id": "GO:0034186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034186", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "1-alkyl-2-acetylglycerophosphocholine esterase activity", "id": "GO:0003847", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003847", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" }, { "name": "phosphatidylcholine-sterol O-acyltransferase activity", "id": "GO:0004607", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004607", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 296, "end_pos": 298, "annotation": "n_glycosylation_sequon" }, { "start_pos": 408, "end_pos": 410, "annotation": "n_glycosylation_sequon" }, { "start_pos": 44, "end_pos": 46, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "O- and N-glycosylated. O-glycosylation on Thr-431 and Ser-433 consists of sialylated galactose beta 1-->3N-acetylgalactosamine structures. N-glycosylated sites contain sialylated triantennary and/or biantennary complex structures.", "evidence": [ { "database": "UniProtKB", "id": "P04180", "url": "https://www.uniprot.org/uniprot/P04180" }, { "database": "PubMed", "id": "16335952", "url": "https://glygen.org/publication/PubMed/16335952" }, { "database": "PubMed", "id": "7613477", "url": "https://glygen.org/publication/PubMed/7613477" } ] } ], "interactions": [], "reactions": [ { "id": "17777", "name": "", "equation": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35264-1", "O88202-1", "O35263-1", "P83006-1", "P18424-1", "A6JJ35-1", "P68402-1", "Q86U10-1", "Q13093-1", "Q99487-1", "Q15102-1", "P04180-1", "Q60963-1", "A0JNU3-1", "Q61205-1", "Q8VDG7-1", "Q61206-1", "P16301-1" ], "evidence": [ { "id": "17777", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17777" } ] }, { "id": "21204", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "21204", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21204" } ] }, { "id": "40427", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "D3ZRC4-1", "P04055-1", "P50393-1", "P18424-1", "P51433-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "P53816-1", "Q86XP0-1", "P0C869-1", "P04180-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "P04054-1", "Q3MJ16-3", "Q9UP65-1", "P39877-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q8R3U1-1", "Q50L43-1", "Q8K1N1-1", "Q9Z0Y2-1", "P97391-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q8BZT7-1", "P16301-1", "Q64GA5-1" ], "evidence": [ { "id": "40427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40427" } ] }, { "id": "40811", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "D3ZRC4-1", "O54728-1", "P50393-1", "P18424-1", "P14423-1", "P53816-1", "Q86XP0-1", "Q6P1J6-1", "P04180-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "Q9UNK4-1", "P14555-1", "Q9UP65-1", "Q9NZK7-1", "Q9NP80-1", "Q8R3U1-1", "Q50L43-1", "Q8K1N1-1", "P31482-1", "P47713-1", "Q9WVF6-1", "P97819-1", "Q50L41-1", "Q3TTY0-1", "Q9QUL3-1", "Q8BZT7-1", "P16301-1", "Q64GA5-1", "Q9VMM8-1" ], "evidence": [ { "id": "40811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40811" } ] }, { "id": "43216", "name": "", "equation": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "43216", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43216" } ] }, { "id": "43224", "name": "", "equation": "(24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "43224", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43224" } ] }, { "id": "53448", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53448", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53448" } ] }, { "id": "53456", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z-octadecenoate)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53456", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53456" } ] }, { "id": "53460", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (5Z,8Z,11Z)-eicosatrienoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53460", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53460" } ] }, { "id": "53464", "name": "", "equation": "1-hexadecanoyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (8Z,11Z,14Z)-eicosatrienoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53464", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53464" } ] }, { "id": "53468", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholine + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53468", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53468" } ] }, { "id": "53472", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + cholesterol = 1-hexadecanoyl-sn-glycero-3-phosphocholine + cholesteryl (9Z,12Z)-octadecadienoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53472", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53472" } ] }, { "id": "53476", "name": "", "equation": "1-hexadecanoyl-2-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (6Z,9Z,12Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53476", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53476" } ] }, { "id": "53516", "name": "", "equation": "1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53516", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53516" } ] }, { "id": "53520", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53520", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53520" } ] }, { "id": "53636", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + 1-O-alkyl-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P18424-1", "P04180-1", "P16301-1" ], "evidence": [ { "id": "53636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53636" } ] }, { "id": "R-HSA-264678", "name": "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex", "equation": "", "summary": "LCAT (lecithin-cholesterol acyltransferase) associates strongly but reversibly with discoidal HDL particles (Jonas 2000).", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04180-1" ], "evidence": [ { "id": "R-HSA-264678", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-264678" } ] }, { "id": "R-HSA-264689", "name": "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL", "equation": "", "summary": "The LCAT:discoidal HDL complex dissociates reversibly to yield LCAT and a discoidal HDL particle.", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04180-1" ], "evidence": [ { "id": "R-HSA-264689", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-264689" } ] }, { "id": "R-HSA-264695", "name": "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "equation": "", "summary": "LCAT activated by apoA-I catalyzes the reaction of cholesterol and phosphatidylcholine to yield cholesterol esterified with a long-chain fatty acid and 2-lysophosphatidylcholine. While this reaction was first studied in vitro using purified proteins in solution, it occurs in vivo on the surfaces of HDL particles where transiently-bound LCAT is activated by HDL-associated apoA-I protein and consumes HDL-associated cholesterol and phosphatidylcholine. The cholesterol ester reaction product is strongly associated with the HDL particle because of its increased hydrophobicity, while the 2-lysophosphatidylcholine product is released from the particle (Fielding et al. 1972 [2 references]; Adimoolam et al. 1998).", "cellular_location": "extracellular region", "input_participant_list": [ "R-ALL-382539" ], "output_participant_list": [ "R-ALL-171076", "R-ALL-194236" ], "enzyme_list": [ "P04180-1" ], "evidence": [ { "id": "R-HSA-264695", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-264695" } ] }, { "id": "R-HSA-266310", "name": "LCAT:spherical HDL complex <=> LCAT + spherical HDL", "equation": "", "summary": "The LCAT:spherical HDL complex dissociates reversibly to yield LCAT and a spherical HDL particle.", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04180-1" ], "evidence": [ { "id": "R-HSA-266310", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-266310" } ] }, { "id": "R-HSA-266315", "name": "LCAT + spherical HDL <=> LCAT:spherical HDL complex", "equation": "", "summary": "LCAT (lecithin-cholesterol acyltransferase) associates strongly but reversibly with spherical HDL particles (Jonas 2000).", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P04180-1" ], "evidence": [ { "id": "R-HSA-266315", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-266315" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-171076", "participant_name": "CHEST [extracellular region]", "crossref": [ { "id": "C02530", "database": "COMPOUND", "url": "" }, { "id": "17002", "database": "ChEBI", "url": "" }, { "id": "17002", "database": "ChEBI", "url": "" }, { "id": "C02530", "database": "COMPOUND", "url": "" }, { "id": "17002", "database": "ChEBI", "url": "" }, { "id": "C02530", "database": "COMPOUND", "url": "" }, { "id": "17002", "database": "ChEBI", "url": "" }, { "id": "C02530", "database": "COMPOUND", "url": "" }, { "id": "17002", "database": "ChEBI", "url": "" }, { "id": "C02530", "database": "COMPOUND", "url": "" }, { "id": "17002", "database": "ChEBI", "url": "" }, { "id": "C02530", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-194236", "participant_name": "1-acyl LPC [extracellular region]", "crossref": [ { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-382539", "participant_name": "PC [extracellular region]", "crossref": [ { "id": "57643", "database": "ChEBI", "url": "" }, { "id": "57643", "database": "ChEBI", "url": "" }, { "id": "57643", "database": "ChEBI", "url": "" }, { "id": "57643", "database": "ChEBI", "url": "" }, { "id": "57643", "database": "ChEBI", "url": "" }, { "id": "57643", "database": "ChEBI", "url": "" }, { "id": "57643", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0JNU3", "gene_name": "Aspg", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] } ] }, { "uniprot_ac": "A6JJ35", "gene_name": "Pla2g7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A6JJ35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6JJ35" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "A6JJ35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6JJ35" } ] } ] }, { "uniprot_ac": "D3Z9B7", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] } ] }, { "uniprot_ac": "D3ZQH6", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] } ] }, { "uniprot_ac": "D3ZRC4", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] } ] }, { "uniprot_ac": "D4A1I6", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] } ] }, { "uniprot_ac": "F1LPY6", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] } ] }, { "uniprot_ac": "O35263", "gene_name": "Pafah1b3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O35263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35263" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "O35263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35263" } ] } ] }, { "uniprot_ac": "O35264", "gene_name": "Pafah1b2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O35264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35264" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "O35264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35264" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O88202", "gene_name": "Aspg", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] } ] }, { "uniprot_ac": "P04054", "gene_name": "PLA2G1B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] } ] }, { "uniprot_ac": "P04055", "gene_name": "Pla2g1b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] } ] }, { "uniprot_ac": "P04180", "gene_name": "LCAT", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] } ] }, { "uniprot_ac": "P0C869", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] } ] }, { "uniprot_ac": "P0C871", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] } ] }, { "uniprot_ac": "P14423", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] } ] }, { "uniprot_ac": "P14555", "gene_name": "PLA2G2A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] } ] }, { "uniprot_ac": "P16301", "gene_name": "Lcat", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] } ] }, { "uniprot_ac": "P18424", "gene_name": "Lcat", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] } ] }, { "uniprot_ac": "P31482", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] } ] }, { "uniprot_ac": "P39877", "gene_name": "PLA2G5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] } ] }, { "uniprot_ac": "P47712", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] } ] }, { "uniprot_ac": "P47713", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] } ] }, { "uniprot_ac": "P50393", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] } ] }, { "uniprot_ac": "P51433", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] } ] }, { "uniprot_ac": "P53816", "gene_name": "PLAAT3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] } ] }, { "uniprot_ac": "P53817", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] } ] }, { "uniprot_ac": "P68402", "gene_name": "PAFAH1B2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68402", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68402" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68402", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68402" } ] } ] }, { "uniprot_ac": "P83006", "gene_name": "Pafah2", "activity": [ { "ec_number": "2.3.1.149", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid.", "evidence": [ { "id": "P83006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83006" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P83006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83006" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P83006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83006" } ] } ] }, { "uniprot_ac": "P97391", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "Q13093", "gene_name": "PLA2G7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q13093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13093" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q13093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13093" } ] } ] }, { "uniprot_ac": "Q15102", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q15102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15102" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q15102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15102" } ] } ] }, { "uniprot_ac": "Q3MJ16", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q50L41", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] } ] }, { "uniprot_ac": "Q50L42", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] } ] }, { "uniprot_ac": "Q50L43", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] } ] }, { "uniprot_ac": "Q60963", "gene_name": "Pla2g7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q60963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60963" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q60963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60963" } ] } ] }, { "uniprot_ac": "Q61205", "gene_name": "Pafah1b3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q61205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61205" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q61205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61205" } ] } ] }, { "uniprot_ac": "Q61206", "gene_name": "Pafah1b2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q61206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61206" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q61206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61206" } ] } ] }, { "uniprot_ac": "Q64GA5", "gene_name": "Pla2g4c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] } ] }, { "uniprot_ac": "Q68DD2", "gene_name": "PLA2G4F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] } ] }, { "uniprot_ac": "Q6P1J6", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q86U10", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] } ] }, { "uniprot_ac": "Q86XP0", "gene_name": "PLA2G4D", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q86XP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XP0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q86XP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XP0" } ] } ] }, { "uniprot_ac": "Q8BZT7", "gene_name": "Pla2g3", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZT7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8BZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZT7" } ] } ] }, { "uniprot_ac": "Q8K1N1", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] } ] }, { "uniprot_ac": "Q8R3U1", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": 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"activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] } ] }, { "uniprot_ac": "Q9NZ20", "gene_name": "PLA2G3", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ20" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ20" } ] } ] }, { "uniprot_ac": "Q9NZK7", "gene_name": "PLA2G2E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZK7" } ] }, { "ec_number": "3.1.1.4", "activity": "", 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