{
"uniprot_canonical_ac": "P04049-1",
"uniprot_ac": "P04049",
"uniprot_id": "RAF1_HUMAN",
"mass": {
"chemical_mass": 73052.0,
"monoisotopic_mass": 73052.0
},
"refseq": {
"ac": "NP_002871",
"name": "RAF proto-oncogene serine/threonine-protein kinase isoform b",
"summary": "This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
},
"gene_names": [
{
"name": "RAF1",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P04049",
"id": "P04049"
},
{
"name": "RAF1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871",
"id": "NP_002871"
},
{
"name": "RAF",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/P04049",
"id": "P04049"
},
{
"name": "c-Raf; CMD1NN; CRAF; NS5; Raf-1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871",
"id": "NP_002871"
}
],
"protein_names": [
{
"name": "RAF proto-oncogene serine/threonine-protein kinase",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P04049"
},
{
"name": "2.7.11.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P04049"
},
{
"name": "Proto-oncogene c-RAF",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P04049"
},
{
"name": "RAF proto-oncogene serine/threonine-protein kinase isoform b",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871",
"id": "NP_002871"
},
{
"name": "Raf-1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P04049"
},
{
"name": "cRaf",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P04049"
},
{
"name": "raf proto-oncogene serine/threonine protein kinase; Oncogene RAF1; RAF proto-oncogene serine/threonine-protein kinase; proto-oncogene c-RAF; v-raf-1 murine leukemia viral oncogene homolog 1; C-Raf proto-oncogene, serine/threonine kinase; v-raf-1 murine leukemia viral oncogene-like protein 1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871",
"id": "NP_002871"
}
],
"function": [
{
"annotation": "Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
},
{
"database": "PubMed",
"id": "37344639",
"url": "https://glygen.org/publication/PubMed/37344639"
}
]
},
{
"annotation": "PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
},
{
"database": "PubMed",
"id": "38136612",
"url": "https://glygen.org/publication/PubMed/38136612"
}
]
},
{
"annotation": "Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
},
{
"database": "PubMed",
"id": "37399073",
"url": "https://glygen.org/publication/PubMed/37399073"
}
]
},
{
"annotation": "Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049#function"
},
{
"database": "PubMed",
"id": "11427728",
"url": "https://glygen.org/publication/PubMed/11427728"
},
{
"database": "PubMed",
"id": "16924233",
"url": "https://glygen.org/publication/PubMed/16924233"
},
{
"database": "PubMed",
"id": "15618521",
"url": "https://glygen.org/publication/PubMed/15618521"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
},
{
"database": "PubMed",
"id": "9360956",
"url": "https://glygen.org/publication/PubMed/9360956"
},
{
"database": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
},
{
"database": "PubMed",
"id": "15385642",
"url": "https://glygen.org/publication/PubMed/15385642"
},
{
"database": "PubMed",
"id": "11719507",
"url": "https://glygen.org/publication/PubMed/11719507"
}
]
},
{
"annotation": "TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
},
{
"database": "PubMed",
"id": "37258577",
"url": "https://glygen.org/publication/PubMed/37258577"
}
]
},
{
"annotation": "This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
}
]
}
],
"disease": [
{
"disease_id": "DOID:0060583",
"recommended_name": {
"id": "DOID:0060583",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0060583",
"name": "Noonan syndrome 5",
"description": "A Noonan syndrome that has_material_basis_in mutation in the RAF1 gene."
},
"synonyms": [
{
"id": "DOID:0060583",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0060583",
"name": "NS5",
"description": ""
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "Noonan syndrome 5",
"description": "Any Noonan syndrome in which the cause of the disease is a mutation in the RAF1 gene."
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "NS5",
"description": ""
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "Noonan syndrome 5",
"description": ""
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "Noonan syndrome caused by mutation in RAF1",
"description": ""
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "Noonan syndrome type 5",
"description": ""
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "RAF1 Noonan syndrome",
"description": ""
},
{
"id": "MONDO:0012690",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012690",
"name": "RAF1 gene related Noonan syndrome",
"description": ""
},
{
"id": "MIM:611553",
"resource": "MIM",
"url": "https://www.omim.org/entry/611553",
"name": "Noonan syndrome 5",
"description": "Noonan syndrome 5"
}
],
"evidence": [
{
"id": "611553",
"database": "MIM",
"url": "https://www.omim.org/entry/611553"
}
]
},
{
"disease_id": "DOID:0080549",
"recommended_name": {
"id": "DOID:0080549",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0080549",
"name": "Noonan syndrome with multiple lentigines 2",
"description": "A Noonan syndrome with multiple lentigines that has_material_basis_in heterozygous mutation in the RAF1 gene on chromosome 3p25."
},
"synonyms": [
{
"id": "DOID:0080549",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0080549",
"name": "LEOPARD syndrome 2",
"description": ""
},
{
"id": "MONDO:0012691",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012691",
"name": "LEOPARD syndrome 2",
"description": "Any Noonan syndrome with multiple lentigines in which the cause of the disease is a mutation in the RAF1 gene."
},
{
"id": "MONDO:0012691",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012691",
"name": "LEOPARD syndrome 2",
"description": ""
},
{
"id": "MONDO:0012691",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012691",
"name": "Leopard syndrome type 2",
"description": ""
},
{
"id": "MONDO:0012691",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012691",
"name": "leopard syndrome 2",
"description": ""
},
{
"id": "MONDO:0012691",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012691",
"name": "LPRD2",
"description": ""
},
{
"id": "MIM:611554",
"resource": "MIM",
"url": "https://www.omim.org/entry/611554",
"name": "LEOPARD syndrome 2",
"description": "LEOPARD syndrome 2"
}
],
"evidence": [
{
"id": "611554",
"database": "MIM",
"url": "https://www.omim.org/entry/611554"
}
]
},
{
"disease_id": "DOID:0110432",
"recommended_name": {
"id": "DOID:0110432",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0110432",
"name": "dilated cardiomyopathy 1NN",
"description": "A dilated cardiomyopathy that has_material_basis_in mutation in the RAF1 gene on chromosome 3p25."
},
"synonyms": [
{
"id": "DOID:0110432",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0110432",
"name": "CMD1NN",
"description": ""
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "dilated cardiomyopathy 1NN",
"description": "Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the RAF1 gene."
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "CMD1NN",
"description": ""
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "RAF1 familial isolated dilated cardiomyopathy",
"description": ""
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "cardiomyopathy, dilated, type 1Nn",
"description": ""
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "dilated cardiomyopathy type 1NN",
"description": ""
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "familial isolated dilated cardiomyopathy caused by mutation in RAF1",
"description": ""
},
{
"id": "MONDO:0014396",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0014396",
"name": "cardiomyopathy, dilated, 1NN",
"description": ""
},
{
"id": "MIM:615916",
"resource": "MIM",
"url": "https://www.omim.org/entry/615916",
"name": "Cardiomyopathy, dilated, 1NN",
"description": "Cardiomyopathy, dilated, 1NN"
}
],
"evidence": [
{
"id": "615916",
"database": "MIM",
"url": "https://www.omim.org/entry/615916"
}
]
}
],
"snv": [
{
"evidence": [
{
"id": "rs1553614748",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1553614748"
},
{
"id": "rs1553614748",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs1553614748"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 142,
"end_pos": 142,
"sequence_org": "A",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFA->NFS).",
"chr_id": "3",
"chr_pos": "12608923",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "A142",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs138119947",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138119947"
},
{
"id": "rs138119947",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs138119947#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 175,
"end_pos": 175,
"sequence_org": "H",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HCS->NCS).",
"chr_id": "3",
"chr_pos": "12585142",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "H175",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P04049",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04049"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 186,
"end_pos": 186,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DWS->NWS).",
"chr_id": "3",
"chr_pos": "12608791",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "D186",
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs730881001",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs730881001"
},
{
"id": "rs730881001",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs730881001"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 227,
"end_pos": 227,
"sequence_org": "S",
"sequence_mut": "G",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->G).",
"chr_id": "3",
"chr_pos": "12606202",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S227",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs2059451949",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2059451949"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 23,
"end_pos": 23,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGS->NGS).",
"chr_id": "3",
"chr_pos": "12618655",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D23",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1575565653",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1575565653"
},
{
"id": "rs1575565653",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs1575565653"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 250,
"end_pos": 250,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SLS->NLS).",
"chr_id": "3",
"chr_pos": "12600402",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S250",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "P04049",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04049"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 257,
"end_pos": 257,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "S",
"sequence_mut": "L",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).",
"chr_id": "3",
"chr_pos": "12604200",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "S257",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
},
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
},
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
},
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs1575565653",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1575565653"
},
{
"id": "rs1575565653",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs1575565653"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 283,
"end_pos": 283,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SHS->NHS).",
"chr_id": "3",
"chr_pos": "12600402",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S283",
"keywords": [
"ebi",
"germline"
]
}
],
"mutagenesis": [
{
"start_pos": 338,
"end_pos": 339,
"sequence_org": "SS",
"sequence_mut": "AA",
"comment": "Reduced kinase activity; when associated with 340-D-D-341.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
]
},
{
"start_pos": 338,
"end_pos": 339,
"sequence_org": "SS",
"sequence_mut": "DE",
"comment": "Non-inhibited by PPP5C. Constitutively active and non-inhibited by PPP5C; when associated with 340-D-D-341.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
]
},
{
"start_pos": 340,
"end_pos": 341,
"sequence_org": "YY",
"sequence_mut": "DD",
"comment": "Constitutively active and highly phosphorylated on S-338, inhibited by PPP5C. Reduced kinase activity; when associated with 338-A-A-339. Constitutively active and non-inhibited by PPP5C; when associated with 338-D-E-339.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
]
},
{
"start_pos": 375,
"end_pos": 375,
"sequence_org": "K",
"sequence_mut": "W",
"comment": "Catalytically inactive.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "20956560",
"url": "https://glygen.org/publication/PubMed/20956560"
}
]
},
{
"start_pos": 491,
"end_pos": 491,
"sequence_org": "T",
"sequence_mut": "D",
"comment": "Increased kinase activity but can still be inhibited by PPP5C; when associated with D-494.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
]
},
{
"start_pos": 494,
"end_pos": 494,
"sequence_org": "S",
"sequence_mut": "D",
"comment": "Increased kinase activity but can still be inhibited by PPP5C; when associated with D-491.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
]
},
{
"start_pos": 563,
"end_pos": 563,
"sequence_org": "R",
"sequence_mut": "K",
"comment": "Loss of methylation. Increased stability and catalytic activity in response to EGF treatment.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
}
]
}
],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "93.51",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "92.83",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "95.21",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "89.68",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "96.91",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "97.23",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "90.78",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "93.42",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "97.35",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "92.85",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "95.48",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "97.33",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "96.34",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155"
}
]
}
],
"expression_disease": [
{
"significant": "No",
"trend": "down",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P04049"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
]
}
],
"species": [
{
"name": "Homo sapiens",
"taxid": 9606,
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"common_name": "Human"
}
],
"gene": [
{
"name": "RAF1",
"url": "https://www.uniprot.org/uniprot/P04049",
"locus": {
"chromosome": "3",
"start_pos": 12582101,
"end_pos": 12664201,
"strand": "+",
"evidence": [
{
"database": "Ensembl Gene",
"id": "ENSG00000132155",
"url": "https://www.ensembl.org/id/ENSG00000132155"
}
]
}
}
],
"crossref": [
{
"id": "ENSG00000132155",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000132155",
"database": "Bgee",
"categories": [
"Gene Expression"
]
},
{
"id": "P04049",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P04049",
"database": "BioMuta",
"categories": [
"Variation"
]
},
{
"id": "2.7.10.2",
"url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.10.2&UniProtAcc=P04049",
"database": "BRENDA",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "cd14062",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14062",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd14149",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14149",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd17135",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17135",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd20870",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20870",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "CHEMBL1906",
"url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL1906",
"database": "ChEMBL",
"categories": [
"Other"
]
},
{
"id": "RAF1",
"url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=RAF1",
"database": "GeneCards",
"categories": [
"Gene Annotation",
"Organism-specific"
]
},
{
"id": "5894",
"url": "https://www.ncbi.nlm.nih.gov/gene/5894",
"database": "GeneID",
"categories": [
"Genome Annotation"
]
},
{
"id": "9829",
"url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9829",
"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "P04049",
"url": "https://www.ebi.ac.uk/intact/interactors/id:P04049*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR000719",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000719",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001245",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001245",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR002219",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR002219",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR003116",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR003116",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR008271",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR008271",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR011009",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR011009",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR017441",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR017441",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR020454",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR020454",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR029071",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR029071",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR046349",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR046349",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:5894",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5894",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "164760",
"url": "http://www.omim.org/entry/164760",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "611553",
"url": "http://www.omim.org/entry/611553",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "611554",
"url": "http://www.omim.org/entry/611554",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "615916",
"url": "http://www.omim.org/entry/615916",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_P04049",
"url": "https://www.nextprot.org/entry/NX_P04049",
"database": "neXtProt",
"categories": [
"Protein",
"Organism-specific"
]
},
{
"id": "P04049",
"url": "https://oglcnac.org/atlas/detail/P04049",
"database": "O-GlcNAc Atlas",
"categories": [
"Glycoproteomics"
]
},
{
"id": "P04049",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04049",
"database": "O-GlcNAc Database",
"categories": [
"Glycoproteomics"
]
},
{
"id": "SPSSWCH",
"url": "https://omabrowser.org/oma/group/SPSSWCH/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "4560496at2759",
"url": "http://www.orthodb.org/?query=4560496at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR44329",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44329",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR44329:SF22",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44329:SF22",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "1C1Y",
"url": "https://www.rcsb.org/structure/1C1Y",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1FAQ",
"url": "https://www.rcsb.org/structure/1FAQ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1FAR",
"url": "https://www.rcsb.org/structure/1FAR",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1GUA",
"url": "https://www.rcsb.org/structure/1GUA",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "1RFA",
"url": "https://www.rcsb.org/structure/1RFA",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3CU8",
"url": "https://www.rcsb.org/structure/3CU8",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3IQJ",
"url": "https://www.rcsb.org/structure/3IQJ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3IQU",
"url": "https://www.rcsb.org/structure/3IQU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3IQV",
"url": "https://www.rcsb.org/structure/3IQV",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KUC",
"url": "https://www.rcsb.org/structure/3KUC",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3KUD",
"url": "https://www.rcsb.org/structure/3KUD",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3NKX",
"url": "https://www.rcsb.org/structure/3NKX",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3O8I",
"url": "https://www.rcsb.org/structure/3O8I",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3OMV",
"url": "https://www.rcsb.org/structure/3OMV",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4FJ3",
"url": "https://www.rcsb.org/structure/4FJ3",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4G0N",
"url": "https://www.rcsb.org/structure/4G0N",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4G3X",
"url": "https://www.rcsb.org/structure/4G3X",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4IEA",
"url": "https://www.rcsb.org/structure/4IEA",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4IHL",
"url": "https://www.rcsb.org/structure/4IHL",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6NTC",
"url": "https://www.rcsb.org/structure/6NTC",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6NTD",
"url": "https://www.rcsb.org/structure/6NTD",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6PTS",
"url": "https://www.rcsb.org/structure/6PTS",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6PTW",
"url": "https://www.rcsb.org/structure/6PTW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6VJJ",
"url": "https://www.rcsb.org/structure/6VJJ",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6XGU",
"url": "https://www.rcsb.org/structure/6XGU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6XGV",
"url": "https://www.rcsb.org/structure/6XGV",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6XHA",
"url": "https://www.rcsb.org/structure/6XHA",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6XHB",
"url": "https://www.rcsb.org/structure/6XHB",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6XI7",
"url": "https://www.rcsb.org/structure/6XI7",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7JHP",
"url": "https://www.rcsb.org/structure/7JHP",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7Z37",
"url": "https://www.rcsb.org/structure/7Z37",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "7Z38",
"url": "https://www.rcsb.org/structure/7Z38",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8A68",
"url": "https://www.rcsb.org/structure/8A68",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8A6F",
"url": "https://www.rcsb.org/structure/8A6F",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8A6H",
"url": "https://www.rcsb.org/structure/8A6H",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8ATR",
"url": "https://www.rcsb.org/structure/8ATR",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8ATS",
"url": "https://www.rcsb.org/structure/8ATS",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8AV0",
"url": "https://www.rcsb.org/structure/8AV0",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8EPW",
"url": "https://www.rcsb.org/structure/8EPW",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8GAE",
"url": "https://www.rcsb.org/structure/8GAE",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "8GFT",
"url": "https://www.rcsb.org/structure/8GFT",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00069",
"url": "http://pfam.xfam.org/family/PF00069",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00130",
"url": "http://pfam.xfam.org/family/PF00130",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF02196",
"url": "http://pfam.xfam.org/family/PF02196",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF07714",
"url": "http://pfam.xfam.org/family/PF07714",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "P04049",
"url": "https://pharos.nih.gov/targets/P04049",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR_P04049",
"url": "http://purl.obolibrary.org/obo/PR_P04049",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5674499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674499",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-6802946",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-6802955",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9726840",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726840",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9726842",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9732724",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9732724",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "17989",
"url": "https://www.rhea-db.org/rhea/17989",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "46608",
"url": "https://www.rhea-db.org/rhea/46608",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "A0A0B4J1W9",
"url": "https://www.uniprot.org/uniprot/A0A0B4J1W9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A0B4J1W9-1",
"url": "https://www.uniprot.org/uniprot/A0A0B4J1W9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A0S2Z4L5",
"url": "https://www.uniprot.org/uniprot/A0A0S2Z4L5",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A0S2Z4L5-1",
"url": "https://www.uniprot.org/uniprot/A0A0S2Z4L5-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KQ33",
"url": "https://www.uniprot.org/uniprot/A0A8I5KQ33",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KQ33-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KQ33-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KQV4",
"url": "https://www.uniprot.org/uniprot/A0A8I5KQV4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KQV4-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KQV4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KR46",
"url": "https://www.uniprot.org/uniprot/A0A8I5KR46",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KR46-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KR46-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KRD1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KRD1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KRD1-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KRD1-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KS16",
"url": "https://www.uniprot.org/uniprot/A0A8I5KS16",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KS16-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KS16-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSB0",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSB0",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSB0-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSB0-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSI1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSI1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSI1-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSI1-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSM4",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSM4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSM4-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSM4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSV6",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSV6",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KSV6-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KSV6-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KT32",
"url": "https://www.uniprot.org/uniprot/A0A8I5KT32",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KT32-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KT32-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KTA5",
"url": "https://www.uniprot.org/uniprot/A0A8I5KTA5",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KTA5-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KTA5-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KTK4",
"url": "https://www.uniprot.org/uniprot/A0A8I5KTK4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KTK4-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KTK4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KUW4",
"url": "https://www.uniprot.org/uniprot/A0A8I5KUW4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KUW4-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KUW4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KW44",
"url": "https://www.uniprot.org/uniprot/A0A8I5KW44",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KW44-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KW44-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KWA9",
"url": "https://www.uniprot.org/uniprot/A0A8I5KWA9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KWA9-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KWA9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KWF7",
"url": "https://www.uniprot.org/uniprot/A0A8I5KWF7",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KWF7-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KWF7-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KWS9",
"url": "https://www.uniprot.org/uniprot/A0A8I5KWS9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KWS9-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KWS9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KX50",
"url": "https://www.uniprot.org/uniprot/A0A8I5KX50",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KX50-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KX50-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KYC4",
"url": "https://www.uniprot.org/uniprot/A0A8I5KYC4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KYC4-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KYC4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KYP5",
"url": "https://www.uniprot.org/uniprot/A0A8I5KYP5",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5KYP5-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5KYP5-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5QJG5",
"url": "https://www.uniprot.org/uniprot/A0A8I5QJG5",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5QJG5-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5QJG5-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5QKU8",
"url": "https://www.uniprot.org/uniprot/A0A8I5QKU8",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5QKU8-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5QKU8-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5QKZ6",
"url": "https://www.uniprot.org/uniprot/A0A8I5QKZ6",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8I5QKZ6-1",
"url": "https://www.uniprot.org/uniprot/A0A8I5QKZ6-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H7C155",
"url": "https://www.uniprot.org/uniprot/H7C155",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H7C155-1",
"url": "https://www.uniprot.org/uniprot/H7C155-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P04049-1",
"url": "https://www.uniprot.org/uniprot/P04049-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "P04049-2",
"url": "https://www.uniprot.org/uniprot/P04049-2",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 648,
"header": "sp|P04049-1|RAF1_HUMAN Isoform 1 of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"isoforms": [
{
"isoform_ac": "A0A0B4J1W9-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALK",
"length": 87,
"header": "tr|A0A0B4J1W9-1|A0A0B4J1W9_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=2 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12612009,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000416093.2",
"url": "https://www.ensembl.org/id/ENST00000416093.2"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000391265.2",
"url": "https://www.ensembl.org/id/ENSP00000391265.2"
}
]
}
},
{
"isoform_ac": "A0A0S2Z4L5-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLFSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 615,
"header": "tr|A0A0S2Z4L5-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000688543.1",
"url": "https://www.ensembl.org/id/ENST00000688543.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509612.1",
"url": "https://www.ensembl.org/id/ENSP00000509612.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KQ33-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIASWTERFKLLLGNRSQ",
"length": 346,
"header": "tr|A0A8I5KQ33-1|A0A8I5KQ33_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12599759,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000691724.1",
"url": "https://www.ensembl.org/id/ENST00000691724.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509255.1",
"url": "https://www.ensembl.org/id/ENSP00000509255.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KQV4-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLFSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 611,
"header": "tr|A0A8I5KQV4-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000690397.1",
"url": "https://www.ensembl.org/id/ENST00000690397.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000508730.1",
"url": "https://www.ensembl.org/id/ENSP00000508730.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KR46-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQL",
"length": 193,
"header": "tr|A0A8I5KR46-1|A0A8I5KR46_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12608768,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000685740.1",
"url": "https://www.ensembl.org/id/ENST00000685740.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510566.1",
"url": "https://www.ensembl.org/id/ENSP00000510566.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KRD1-1",
"url": "",
"sequence": {
"sequence": "XKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLMQFEVTANQPHLQPCPVAPTI",
"length": 109,
"header": "tr|A0A8I5KRD1-1|A0A8I5KRD1_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12609335,
"end_pos": 12600242,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000691268.1",
"url": "https://www.ensembl.org/id/ENST00000691268.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509128.1",
"url": "https://www.ensembl.org/id/ENSP00000509128.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KS16-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNMPELESFGGKAMWGLKNGLIHN",
"length": 494,
"header": "tr|A0A8I5KS16-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12585342,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000689876.1",
"url": "https://www.ensembl.org/id/ENST00000689876.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000508535.1",
"url": "https://www.ensembl.org/id/ENSP00000508535.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KSB0-1",
"url": "",
"sequence": {
"sequence": "MSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 573,
"header": "tr|A0A8I5KSB0-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12612044,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000693312.1",
"url": "https://www.ensembl.org/id/ENST00000693312.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000508686.1",
"url": "https://www.ensembl.org/id/ENSP00000508686.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KSI1-1",
"url": "",
"sequence": {
"sequence": "XSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGLAVGVPIKQGRH",
"length": 156,
"header": "tr|A0A8I5KSI1-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12604289,
"end_pos": 12599186,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000688326.1",
"url": "https://www.ensembl.org/id/ENST00000688326.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509907.1",
"url": "https://www.ensembl.org/id/ENSP00000509907.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KSM4-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFVSCRSLLFLAC",
"length": 152,
"header": "tr|A0A8I5KSM4-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12609200,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000687348.1",
"url": "https://www.ensembl.org/id/ENST00000687348.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509787.1",
"url": "https://www.ensembl.org/id/ENSP00000509787.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KSV6-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 644,
"header": "tr|A0A8I5KSV6-1|A0A8I5KSV6_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000690460.1",
"url": "https://www.ensembl.org/id/ENST00000690460.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509106.1",
"url": "https://www.ensembl.org/id/ENSP00000509106.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KT32-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLFSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGYLKD",
"length": 341,
"header": "tr|A0A8I5KT32-1|A0A8I5KT32_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12591838,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000693069.1",
"url": "https://www.ensembl.org/id/ENST00000693069.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510072.1",
"url": "https://www.ensembl.org/id/ENSP00000510072.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KTA5-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLFSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 611,
"header": "tr|A0A8I5KTA5-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000687923.1",
"url": "https://www.ensembl.org/id/ENST00000687923.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510255.1",
"url": "https://www.ensembl.org/id/ENSP00000510255.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KTK4-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGYLKD",
"length": 374,
"header": "tr|A0A8I5KTK4-1|A0A8I5KTK4_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12591838,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000687326.1",
"url": "https://www.ensembl.org/id/ENST00000687326.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509665.1",
"url": "https://www.ensembl.org/id/ENSP00000509665.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KUW4-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVPVLVLKVVLCL",
"length": 80,
"header": "tr|A0A8I5KUW4-1|A0A8I5KUW4_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12612066,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000691396.1",
"url": "https://www.ensembl.org/id/ENST00000691396.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510712.1",
"url": "https://www.ensembl.org/id/ENSP00000510712.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KW44-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIE",
"length": 278,
"header": "tr|A0A8I5KW44-1|A0A8I5KW44_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12604136,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000689033.1",
"url": "https://www.ensembl.org/id/ENST00000689033.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000508983.1",
"url": "https://www.ensembl.org/id/ENSP00000508983.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KWA9-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVRKGRNFCLWTCRSYILESDFDCSFFCYHSIFLNMSLHFKELEILLSSVCTEFNLNGKGPKT",
"length": 287,
"header": "tr|A0A8I5KWA9-1|A0A8I5KWA9_HUMAN Computationally mapped isoform of Raf-1 proto-oncogene, serine/threonine kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12605868,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000689226.1",
"url": "https://www.ensembl.org/id/ENST00000689226.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510613.1",
"url": "https://www.ensembl.org/id/ENSP00000510613.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KWF7-1",
"url": "",
"sequence": {
"sequence": "XDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNSLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 273,
"header": "tr|A0A8I5KWF7-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12591792,
"end_pos": 12584516,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000691888.1",
"url": "https://www.ensembl.org/id/ENST00000691888.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510730.1",
"url": "https://www.ensembl.org/id/ENSP00000510730.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KWS9-1",
"url": "",
"sequence": {
"sequence": "XDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMEPQR",
"length": 91,
"header": "tr|A0A8I5KWS9-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12591792,
"end_pos": 12585243,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000690585.1",
"url": "https://www.ensembl.org/id/ENST00000690585.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510641.1",
"url": "https://www.ensembl.org/id/ENSP00000510641.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KX50-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTV",
"length": 69,
"header": "tr|A0A8I5KX50-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12618515,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000692773.1",
"url": "https://www.ensembl.org/id/ENST00000692773.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509055.1",
"url": "https://www.ensembl.org/id/ENSP00000509055.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KYC4-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNKSLTSIEIYFSMKA",
"length": 486,
"header": "tr|A0A8I5KYC4-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12585779,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000686762.1",
"url": "https://www.ensembl.org/id/ENST00000686762.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509767.1",
"url": "https://www.ensembl.org/id/ENSP00000509767.1"
}
]
}
},
{
"isoform_ac": "A0A8I5KYP5-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGLAVGVPIKQGRH",
"length": 382,
"header": "tr|A0A8I5KYP5-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12599188,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000685738.1",
"url": "https://www.ensembl.org/id/ENST00000685738.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510156.1",
"url": "https://www.ensembl.org/id/ENSP00000510156.1"
}
]
}
},
{
"isoform_ac": "A0A8I5QJG5-1",
"url": "",
"sequence": {
"sequence": "XSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESEASWTERFKLLLGNRSQ",
"length": 78,
"header": "tr|A0A8I5QJG5-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12604289,
"end_pos": 12599757,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000687486.1",
"url": "https://www.ensembl.org/id/ENST00000687486.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509469.1",
"url": "https://www.ensembl.org/id/ENSP00000509469.1"
}
]
}
},
{
"isoform_ac": "A0A8I5QKU8-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNILILKSLSGTDSSEEFLTTTLNTQPQR",
"length": 499,
"header": "tr|A0A8I5QKU8-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12585244,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000693664.1",
"url": "https://www.ensembl.org/id/ENST00000693664.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509614.1",
"url": "https://www.ensembl.org/id/ENSP00000509614.1"
}
]
}
},
{
"isoform_ac": "A0A8I5QKZ6-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 589,
"header": "tr|A0A8I5QKZ6-1|A0A8I5QKZ6_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000689389.1",
"url": "https://www.ensembl.org/id/ENST00000689389.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000510213.1",
"url": "https://www.ensembl.org/id/ENSP00000510213.1"
}
]
}
},
{
"isoform_ac": "H7C155-1",
"url": "",
"sequence": {
"sequence": "XSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 421,
"header": "tr|H7C155-1|RAF1_HUMAN Computationally mapped isoform of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=2 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12604289,
"end_pos": 12584515,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000432427.3",
"url": "https://www.ensembl.org/id/ENST00000432427.3"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000398591.3",
"url": "https://www.ensembl.org/id/ENSP00000398591.3"
}
]
}
},
{
"isoform_ac": "P04049-1",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 648,
"header": "sp|P04049-1|RAF1_HUMAN Isoform 1 of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000685653.1",
"url": "https://www.ensembl.org/id/ENST00000685653.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000509968.1",
"url": "https://www.ensembl.org/id/ENSP00000509968.1"
}
]
}
},
{
"isoform_ac": "P04049-2",
"url": "",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 668,
"header": "sp|P04049-2|RAF1_HUMAN Isoform 2 of RAF proto-oncogene serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=RAF1 PE=1 SV=1 CANONICAL=P04049-1"
},
"locus": {
"chromosome": "3",
"start_pos": 12618721,
"end_pos": 12584517,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000442415.7",
"url": "https://www.ensembl.org/id/ENST00000442415.7"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000401888.2",
"url": "https://www.ensembl.org/id/ENSP00000401888.2"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 227,
"start_aa": "Ser",
"end_pos": 227,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser227",
"evidence": [
{
"id": "P04049",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04049"
},
{
"id": "31521821",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/31521821"
},
{
"id": "33909326",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/33909326"
},
{
"id": "P04049",
"database": "O-GlcNAc Atlas",
"url": "https://oglcnac.org/atlas/detail/P04049"
}
]
}
],
"phosphorylation": [
{
"start_pos": 233,
"end_pos": 233,
"kinase_uniprot_canonical_ac": "P17252-1",
"kinase_gene_name": "PRKCA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "12551925",
"url": "https://glygen.org/publication/PubMed/12551925"
}
],
"site_lbl": "Ser233"
},
{
"start_pos": 233,
"end_pos": 233,
"kinase_uniprot_canonical_ac": "P17612-1",
"kinase_gene_name": "PRKACA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11997508",
"url": "https://glygen.org/publication/PubMed/11997508"
}
],
"site_lbl": "Ser233"
},
{
"start_pos": 233,
"end_pos": 233,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "32387766",
"url": ""
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "12801936",
"url": "https://glygen.org/publication/PubMed/12801936"
},
{
"database": "PubMed",
"id": "22922483",
"url": "https://glygen.org/publication/PubMed/22922483"
}
],
"site_lbl": "Ser233"
},
{
"start_pos": 244,
"end_pos": 244,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser244"
},
{
"start_pos": 252,
"end_pos": 252,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "17525332",
"url": "https://glygen.org/publication/PubMed/17525332"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
}
],
"site_lbl": "Ser252"
},
{
"start_pos": 257,
"end_pos": 257,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "18220336",
"url": "https://glygen.org/publication/PubMed/18220336"
},
{
"database": "PubMed",
"id": "26659599",
"url": "https://glygen.org/publication/PubMed/26659599"
}
],
"site_lbl": "Ser257"
},
{
"start_pos": 258,
"end_pos": 258,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "18220336",
"url": "https://glygen.org/publication/PubMed/18220336"
},
{
"database": "PubMed",
"id": "26659599",
"url": "https://glygen.org/publication/PubMed/26659599"
}
],
"site_lbl": "Thr258"
},
{
"start_pos": 259,
"end_pos": 259,
"kinase_uniprot_canonical_ac": "P17612-1",
"kinase_gene_name": "PRKACA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10576742",
"url": "https://glygen.org/publication/PubMed/10576742"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "11997508",
"url": "https://glygen.org/publication/PubMed/11997508"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "18767875",
"url": "https://glygen.org/publication/PubMed/18767875"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20230923",
"url": "https://glygen.org/publication/PubMed/20230923"
}
],
"site_lbl": "Ser259"
},
{
"start_pos": 259,
"end_pos": 259,
"kinase_uniprot_canonical_ac": "P31749-1",
"kinase_gene_name": "AKT1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10576742",
"url": "https://glygen.org/publication/PubMed/10576742"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "11997508",
"url": "https://glygen.org/publication/PubMed/11997508"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "18767875",
"url": "https://glygen.org/publication/PubMed/18767875"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20230923",
"url": "https://glygen.org/publication/PubMed/20230923"
},
{
"database": "PubMed",
"id": "12087097",
"url": "https://glygen.org/publication/PubMed/12087097"
},
{
"database": "PubMed",
"id": "10576741",
"url": "https://glygen.org/publication/PubMed/10576741"
},
{
"database": "PubMed",
"id": "16854453",
"url": "https://glygen.org/publication/PubMed/16854453"
}
],
"site_lbl": "Ser259"
},
{
"start_pos": 259,
"end_pos": 259,
"kinase_uniprot_canonical_ac": "Q13131-1",
"kinase_gene_name": "PRKAA1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
}
],
"site_lbl": "Ser259"
},
{
"start_pos": 259,
"end_pos": 259,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by PKA, PKC and PKB/AKT1",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10576742",
"url": "https://glygen.org/publication/PubMed/10576742"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "11997508",
"url": "https://glygen.org/publication/PubMed/11997508"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "18767875",
"url": "https://glygen.org/publication/PubMed/18767875"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20230923",
"url": "https://glygen.org/publication/PubMed/20230923"
},
{
"database": "IntAct",
"id": "P04049",
"url": "https://www.ebi.ac.uk/intact/interactors/id:P04049*"
},
{
"database": "PubMed",
"id": "35044719",
"url": ""
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "18220336",
"url": "https://glygen.org/publication/PubMed/18220336"
},
{
"database": "PubMed",
"id": "12801936",
"url": "https://glygen.org/publication/PubMed/12801936"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "14688280",
"url": "https://glygen.org/publication/PubMed/14688280"
},
{
"database": "PubMed",
"id": "10801873",
"url": "https://glygen.org/publication/PubMed/10801873"
},
{
"database": "PubMed",
"id": "11041243",
"url": "https://glygen.org/publication/PubMed/11041243"
},
{
"database": "PubMed",
"id": "11341776",
"url": "https://glygen.org/publication/PubMed/11341776"
},
{
"database": "PubMed",
"id": "11782426",
"url": "https://glygen.org/publication/PubMed/11782426"
},
{
"database": "PubMed",
"id": "12083801",
"url": "https://glygen.org/publication/PubMed/12083801"
},
{
"database": "PubMed",
"id": "12087097",
"url": "https://glygen.org/publication/PubMed/12087097"
},
{
"database": "PubMed",
"id": "12181740",
"url": "https://glygen.org/publication/PubMed/12181740"
},
{
"database": "PubMed",
"id": "12225966",
"url": "https://glygen.org/publication/PubMed/12225966"
},
{
"database": "PubMed",
"id": "12691603",
"url": "https://glygen.org/publication/PubMed/12691603"
},
{
"database": "PubMed",
"id": "14755538",
"url": "https://glygen.org/publication/PubMed/14755538"
},
{
"database": "PubMed",
"id": "14992682",
"url": "https://glygen.org/publication/PubMed/14992682"
},
{
"database": "PubMed",
"id": "15047712",
"url": "https://glygen.org/publication/PubMed/15047712"
},
{
"database": "PubMed",
"id": "15280158",
"url": "https://glygen.org/publication/PubMed/15280158"
},
{
"database": "PubMed",
"id": "15534860",
"url": "https://glygen.org/publication/PubMed/15534860"
},
{
"database": "PubMed",
"id": "15772344",
"url": "https://glygen.org/publication/PubMed/15772344"
},
{
"database": "PubMed",
"id": "15899852",
"url": "https://glygen.org/publication/PubMed/15899852"
},
{
"database": "PubMed",
"id": "16239230",
"url": "https://glygen.org/publication/PubMed/16239230"
},
{
"database": "PubMed",
"id": "16760675",
"url": "https://glygen.org/publication/PubMed/16760675"
},
{
"database": "PubMed",
"id": "17031853",
"url": "https://glygen.org/publication/PubMed/17031853"
},
{
"database": "PubMed",
"id": "17064357",
"url": "https://glygen.org/publication/PubMed/17064357"
},
{
"database": "PubMed",
"id": "17785857",
"url": "https://glygen.org/publication/PubMed/17785857"
},
{
"database": "PubMed",
"id": "18055485",
"url": "https://glygen.org/publication/PubMed/18055485"
},
{
"database": "PubMed",
"id": "18374541",
"url": "https://glygen.org/publication/PubMed/18374541"
},
{
"database": "PubMed",
"id": "20052757",
"url": "https://glygen.org/publication/PubMed/20052757"
},
{
"database": "PubMed",
"id": "20149136",
"url": "https://glygen.org/publication/PubMed/20149136"
},
{
"database": "PubMed",
"id": "20161842",
"url": "https://glygen.org/publication/PubMed/20161842"
},
{
"database": "PubMed",
"id": "20212043",
"url": "https://glygen.org/publication/PubMed/20212043"
},
{
"database": "PubMed",
"id": "20688159",
"url": "https://glygen.org/publication/PubMed/20688159"
},
{
"database": "PubMed",
"id": "20868520",
"url": "https://glygen.org/publication/PubMed/20868520"
},
{
"database": "PubMed",
"id": "20934465",
"url": "https://glygen.org/publication/PubMed/20934465"
},
{
"database": "PubMed",
"id": "21734462",
"url": "https://glygen.org/publication/PubMed/21734462"
},
{
"database": "PubMed",
"id": "22182854",
"url": "https://glygen.org/publication/PubMed/22182854"
},
{
"database": "PubMed",
"id": "22487193",
"url": "https://glygen.org/publication/PubMed/22487193"
},
{
"database": "PubMed",
"id": "23487407",
"url": "https://glygen.org/publication/PubMed/23487407"
},
{
"database": "PubMed",
"id": "23529931",
"url": "https://glygen.org/publication/PubMed/23529931"
},
{
"database": "PubMed",
"id": "23554907",
"url": "https://glygen.org/publication/PubMed/23554907"
},
{
"database": "PubMed",
"id": "24625973",
"url": "https://glygen.org/publication/PubMed/24625973"
},
{
"database": "PubMed",
"id": "24732797",
"url": "https://glygen.org/publication/PubMed/24732797"
},
{
"database": "PubMed",
"id": "24853429",
"url": "https://glygen.org/publication/PubMed/24853429"
},
{
"database": "PubMed",
"id": "24922062",
"url": "https://glygen.org/publication/PubMed/24922062"
},
{
"database": "PubMed",
"id": "24929361",
"url": "https://glygen.org/publication/PubMed/24929361"
},
{
"database": "PubMed",
"id": "26442853",
"url": "https://glygen.org/publication/PubMed/26442853"
},
{
"database": "PubMed",
"id": "26659599",
"url": "https://glygen.org/publication/PubMed/26659599"
},
{
"database": "PubMed",
"id": "27527217",
"url": "https://glygen.org/publication/PubMed/27527217"
},
{
"database": "PubMed",
"id": "27534532",
"url": "https://glygen.org/publication/PubMed/27534532"
},
{
"database": "PubMed",
"id": "29097117",
"url": "https://glygen.org/publication/PubMed/29097117"
},
{
"database": "PubMed",
"id": "29515772",
"url": "https://glygen.org/publication/PubMed/29515772"
},
{
"database": "PubMed",
"id": "29545175",
"url": "https://glygen.org/publication/PubMed/29545175"
},
{
"database": "PubMed",
"id": "29917268",
"url": "https://glygen.org/publication/PubMed/29917268"
},
{
"database": "PubMed",
"id": "30368668",
"url": "https://glygen.org/publication/PubMed/30368668"
},
{
"database": "PubMed",
"id": "30909892",
"url": "https://glygen.org/publication/PubMed/30909892"
},
{
"database": "PubMed",
"id": "31285551",
"url": "https://glygen.org/publication/PubMed/31285551"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
},
{
"database": "PubMed",
"id": "11756411",
"url": "https://glygen.org/publication/PubMed/11756411"
},
{
"database": "PubMed",
"id": "16630891",
"url": "https://glygen.org/publication/PubMed/16630891"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
],
"site_lbl": "Ser259"
},
{
"start_pos": 260,
"end_pos": 260,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "20230923",
"url": "https://glygen.org/publication/PubMed/20230923"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "18220336",
"url": "https://glygen.org/publication/PubMed/18220336"
}
],
"site_lbl": "Thr260"
},
{
"start_pos": 268,
"end_pos": 268,
"kinase_uniprot_canonical_ac": "P04049-1",
"kinase_gene_name": "RAF1",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
},
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"site_lbl": "Thr268"
},
{
"start_pos": 268,
"end_pos": 268,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "Phosphothreonine; by autocatalysis",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15642359",
"url": "https://glygen.org/publication/PubMed/15642359"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
}
],
"site_lbl": "Thr268"
},
{
"start_pos": 269,
"end_pos": 269,
"kinase_uniprot_canonical_ac": "Q8IVT5-1",
"kinase_gene_name": "KSR1",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "19766101",
"url": "https://glygen.org/publication/PubMed/19766101"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "11134016",
"url": "https://glygen.org/publication/PubMed/11134016"
},
{
"database": "PubMed",
"id": "7477354",
"url": "https://glygen.org/publication/PubMed/7477354"
}
],
"site_lbl": "Thr269"
},
{
"start_pos": 269,
"end_pos": 269,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "Phosphothreonine; by PKA",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "7477354",
"url": "https://glygen.org/publication/PubMed/7477354"
},
{
"database": "PubMed",
"id": "15642359",
"url": "https://glygen.org/publication/PubMed/15642359"
},
{
"database": "PubMed",
"id": "19766101",
"url": "https://glygen.org/publication/PubMed/19766101"
}
],
"site_lbl": "Thr269"
},
{
"start_pos": 289,
"end_pos": 289,
"kinase_uniprot_canonical_ac": "P27361-1",
"kinase_gene_name": "MAPK3",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "16407412",
"url": "https://glygen.org/publication/PubMed/16407412"
}
],
"site_lbl": "Ser289"
},
{
"start_pos": 289,
"end_pos": 289,
"kinase_uniprot_canonical_ac": "P28482-1",
"kinase_gene_name": "MAPK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
],
"site_lbl": "Ser289"
},
{
"start_pos": 289,
"end_pos": 289,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by MAPK1",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PubMed",
"id": "20149136",
"url": "https://glygen.org/publication/PubMed/20149136"
},
{
"database": "PubMed",
"id": "23554907",
"url": "https://glygen.org/publication/PubMed/23554907"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
},
{
"database": "PubMed",
"id": "19690332",
"url": "https://glygen.org/publication/PubMed/19690332"
}
],
"site_lbl": "Ser289"
},
{
"start_pos": 291,
"end_pos": 291,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
],
"site_lbl": "Ser291"
},
{
"start_pos": 294,
"end_pos": 294,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
}
],
"site_lbl": "Ser294"
},
{
"start_pos": 295,
"end_pos": 295,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
],
"site_lbl": "Ser295"
},
{
"start_pos": 296,
"end_pos": 296,
"kinase_uniprot_canonical_ac": "P27361-1",
"kinase_gene_name": "MAPK3",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "16407412",
"url": "https://glygen.org/publication/PubMed/16407412"
}
],
"site_lbl": "Ser296"
},
{
"start_pos": 296,
"end_pos": 296,
"kinase_uniprot_canonical_ac": "P28482-1",
"kinase_gene_name": "MAPK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser296"
},
{
"start_pos": 296,
"end_pos": 296,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "15642359",
"url": "https://glygen.org/publication/PubMed/15642359"
},
{
"database": "PubMed",
"id": "20149136",
"url": "https://glygen.org/publication/PubMed/20149136"
},
{
"database": "PubMed",
"id": "31541179",
"url": "https://glygen.org/publication/PubMed/31541179"
}
],
"site_lbl": "Ser296"
},
{
"start_pos": 29,
"end_pos": 29,
"kinase_uniprot_canonical_ac": "P28482-1",
"kinase_gene_name": "MAPK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
],
"site_lbl": "Ser29"
},
{
"start_pos": 29,
"end_pos": 29,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by MAPK1",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
}
],
"site_lbl": "Ser29"
},
{
"start_pos": 301,
"end_pos": 301,
"kinase_uniprot_canonical_ac": "P27361-1",
"kinase_gene_name": "MAPK3",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "16407412",
"url": "https://glygen.org/publication/PubMed/16407412"
}
],
"site_lbl": "Ser301"
},
{
"start_pos": 301,
"end_pos": 301,
"kinase_uniprot_canonical_ac": "P28482-1",
"kinase_gene_name": "MAPK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser301"
},
{
"start_pos": 301,
"end_pos": 301,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by MAPK1",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "15642359",
"url": "https://glygen.org/publication/PubMed/15642359"
},
{
"database": "PubMed",
"id": "20149136",
"url": "https://glygen.org/publication/PubMed/20149136"
},
{
"database": "PubMed",
"id": "31541179",
"url": "https://glygen.org/publication/PubMed/31541179"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "PubMed",
"id": "19690332",
"url": "https://glygen.org/publication/PubMed/19690332"
}
],
"site_lbl": "Ser301"
},
{
"start_pos": 303,
"end_pos": 303,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18767875",
"url": "https://glygen.org/publication/PubMed/18767875"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
}
],
"site_lbl": "Thr303"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "O75914-1",
"kinase_gene_name": "PAK3",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
},
{
"database": "PubMed",
"id": "11733498",
"url": "https://glygen.org/publication/PubMed/11733498"
},
{
"database": "PubMed",
"id": "9234708",
"url": "https://glygen.org/publication/PubMed/9234708"
},
{
"database": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "P12931-1",
"kinase_gene_name": "SRC",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "17097642",
"url": "https://glygen.org/publication/PubMed/17097642"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "P53350-1",
"kinase_gene_name": "PLK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "27003818",
"url": "https://glygen.org/publication/PubMed/27003818"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "Q13153-1",
"kinase_gene_name": "PAK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
},
{
"database": "PubMed",
"id": "11733498",
"url": "https://glygen.org/publication/PubMed/11733498"
},
{
"database": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
},
{
"database": "PubMed",
"id": "9234708",
"url": "https://glygen.org/publication/PubMed/9234708"
},
{
"database": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "10801448",
"url": "https://glygen.org/publication/PubMed/10801448"
},
{
"database": "PubMed",
"id": "18775988",
"url": "https://glygen.org/publication/PubMed/18775988"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "Q15382-1",
"kinase_gene_name": "RHEB",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "16803888",
"url": "https://glygen.org/publication/PubMed/16803888"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "Q16512-1",
"kinase_gene_name": "PKN1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11733498",
"url": "https://glygen.org/publication/PubMed/11733498"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 338,
"end_pos": 338,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by PAK1, PAK2, PAK3 and PAK5",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18465753",
"url": "https://glygen.org/publication/PubMed/18465753"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "12719581",
"url": "https://glygen.org/publication/PubMed/12719581"
},
{
"database": "PubMed",
"id": "11376654",
"url": "https://glygen.org/publication/PubMed/11376654"
},
{
"database": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
},
{
"database": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
},
{
"database": "PubMed",
"id": "10712905",
"url": "https://glygen.org/publication/PubMed/10712905"
},
{
"database": "PubMed",
"id": "10801448",
"url": "https://glygen.org/publication/PubMed/10801448"
},
{
"database": "PubMed",
"id": "11259591",
"url": "https://glygen.org/publication/PubMed/11259591"
},
{
"database": "PubMed",
"id": "11274179",
"url": "https://glygen.org/publication/PubMed/11274179"
},
{
"database": "PubMed",
"id": "11782426",
"url": "https://glygen.org/publication/PubMed/11782426"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "12446733",
"url": "https://glygen.org/publication/PubMed/12446733"
},
{
"database": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
},
{
"database": "PubMed",
"id": "15280158",
"url": "https://glygen.org/publication/PubMed/15280158"
},
{
"database": "PubMed",
"id": "15470067",
"url": "https://glygen.org/publication/PubMed/15470067"
},
{
"database": "PubMed",
"id": "15601627",
"url": "https://glygen.org/publication/PubMed/15601627"
},
{
"database": "PubMed",
"id": "15705600",
"url": "https://glygen.org/publication/PubMed/15705600"
},
{
"database": "PubMed",
"id": "15899852",
"url": "https://glygen.org/publication/PubMed/15899852"
},
{
"database": "PubMed",
"id": "16129686",
"url": "https://glygen.org/publication/PubMed/16129686"
},
{
"database": "PubMed",
"id": "16405965",
"url": "https://glygen.org/publication/PubMed/16405965"
},
{
"database": "PubMed",
"id": "17055484",
"url": "https://glygen.org/publication/PubMed/17055484"
},
{
"database": "PubMed",
"id": "17064357",
"url": "https://glygen.org/publication/PubMed/17064357"
},
{
"database": "PubMed",
"id": "17277048",
"url": "https://glygen.org/publication/PubMed/17277048"
},
{
"database": "PubMed",
"id": "17428866",
"url": "https://glygen.org/publication/PubMed/17428866"
},
{
"database": "PubMed",
"id": "17785857",
"url": "https://glygen.org/publication/PubMed/17785857"
},
{
"database": "PubMed",
"id": "18064632",
"url": "https://glygen.org/publication/PubMed/18064632"
},
{
"database": "PubMed",
"id": "18775988",
"url": "https://glygen.org/publication/PubMed/18775988"
},
{
"database": "PubMed",
"id": "18821707",
"url": "https://glygen.org/publication/PubMed/18821707"
},
{
"database": "PubMed",
"id": "19133285",
"url": "https://glygen.org/publication/PubMed/19133285"
},
{
"database": "PubMed",
"id": "19288477",
"url": "https://glygen.org/publication/PubMed/19288477"
},
{
"database": "PubMed",
"id": "19710016",
"url": "https://glygen.org/publication/PubMed/19710016"
},
{
"database": "PubMed",
"id": "19717011",
"url": "https://glygen.org/publication/PubMed/19717011"
},
{
"database": "PubMed",
"id": "20015475",
"url": "https://glygen.org/publication/PubMed/20015475"
},
{
"database": "PubMed",
"id": "20141835",
"url": "https://glygen.org/publication/PubMed/20141835"
},
{
"database": "PubMed",
"id": "20509944",
"url": "https://glygen.org/publication/PubMed/20509944"
},
{
"database": "PubMed",
"id": "20685651",
"url": "https://glygen.org/publication/PubMed/20685651"
},
{
"database": "PubMed",
"id": "20868520",
"url": "https://glygen.org/publication/PubMed/20868520"
},
{
"database": "PubMed",
"id": "21596018",
"url": "https://glygen.org/publication/PubMed/21596018"
},
{
"database": "PubMed",
"id": "22096607",
"url": "https://glygen.org/publication/PubMed/22096607"
},
{
"database": "PubMed",
"id": "22158035",
"url": "https://glygen.org/publication/PubMed/22158035"
},
{
"database": "PubMed",
"id": "22592532",
"url": "https://glygen.org/publication/PubMed/22592532"
},
{
"database": "PubMed",
"id": "22880011",
"url": "https://glygen.org/publication/PubMed/22880011"
},
{
"database": "PubMed",
"id": "23653349",
"url": "https://glygen.org/publication/PubMed/23653349"
},
{
"database": "PubMed",
"id": "23987506",
"url": "https://glygen.org/publication/PubMed/23987506"
},
{
"database": "PubMed",
"id": "24023871",
"url": "https://glygen.org/publication/PubMed/24023871"
},
{
"database": "PubMed",
"id": "24568222",
"url": "https://glygen.org/publication/PubMed/24568222"
},
{
"database": "PubMed",
"id": "24853429",
"url": "https://glygen.org/publication/PubMed/24853429"
},
{
"database": "PubMed",
"id": "25204017",
"url": "https://glygen.org/publication/PubMed/25204017"
},
{
"database": "PubMed",
"id": "26058013",
"url": "https://glygen.org/publication/PubMed/26058013"
},
{
"database": "PubMed",
"id": "26100670",
"url": "https://glygen.org/publication/PubMed/26100670"
},
{
"database": "PubMed",
"id": "26154409",
"url": "https://glygen.org/publication/PubMed/26154409"
},
{
"database": "PubMed",
"id": "26242183",
"url": "https://glygen.org/publication/PubMed/26242183"
},
{
"database": "PubMed",
"id": "26333361",
"url": "https://glygen.org/publication/PubMed/26333361"
},
{
"database": "PubMed",
"id": "26442853",
"url": "https://glygen.org/publication/PubMed/26442853"
},
{
"database": "PubMed",
"id": "26565813",
"url": "https://glygen.org/publication/PubMed/26565813"
},
{
"database": "PubMed",
"id": "27527217",
"url": "https://glygen.org/publication/PubMed/27527217"
},
{
"database": "PubMed",
"id": "27534532",
"url": "https://glygen.org/publication/PubMed/27534532"
},
{
"database": "PubMed",
"id": "27999210",
"url": "https://glygen.org/publication/PubMed/27999210"
},
{
"database": "PubMed",
"id": "28694330",
"url": "https://glygen.org/publication/PubMed/28694330"
},
{
"database": "PubMed",
"id": "28947956",
"url": "https://glygen.org/publication/PubMed/28947956"
},
{
"database": "PubMed",
"id": "29662630",
"url": "https://glygen.org/publication/PubMed/29662630"
},
{
"database": "PubMed",
"id": "30586319",
"url": "https://glygen.org/publication/PubMed/30586319"
},
{
"database": "PubMed",
"id": "30971268",
"url": "https://glygen.org/publication/PubMed/30971268"
},
{
"database": "PubMed",
"id": "31091164",
"url": "https://glygen.org/publication/PubMed/31091164"
},
{
"database": "PubMed",
"id": "31213532",
"url": "https://glygen.org/publication/PubMed/31213532"
},
{
"database": "PubMed",
"id": "31285551",
"url": "https://glygen.org/publication/PubMed/31285551"
},
{
"database": "PubMed",
"id": "31541179",
"url": "https://glygen.org/publication/PubMed/31541179"
},
{
"database": "PubMed",
"id": "31638257",
"url": "https://glygen.org/publication/PubMed/31638257"
},
{
"database": "PubMed",
"id": "31883527",
"url": "https://glygen.org/publication/PubMed/31883527"
},
{
"database": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
},
{
"database": "PubMed",
"id": "11733498",
"url": "https://glygen.org/publication/PubMed/11733498"
}
],
"site_lbl": "Ser338"
},
{
"start_pos": 339,
"end_pos": 339,
"kinase_uniprot_canonical_ac": "O75914-1",
"kinase_gene_name": "PAK3",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
}
],
"site_lbl": "Ser339"
},
{
"start_pos": 339,
"end_pos": 339,
"kinase_uniprot_canonical_ac": "P12931-1",
"kinase_gene_name": "SRC",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "17097642",
"url": "https://glygen.org/publication/PubMed/17097642"
}
],
"site_lbl": "Ser339"
},
{
"start_pos": 339,
"end_pos": 339,
"kinase_uniprot_canonical_ac": "P53350-1",
"kinase_gene_name": "PLK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "27003818",
"url": "https://glygen.org/publication/PubMed/27003818"
}
],
"site_lbl": "Ser339"
},
{
"start_pos": 339,
"end_pos": 339,
"kinase_uniprot_canonical_ac": "Q13153-1",
"kinase_gene_name": "PAK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
},
{
"database": "PubMed",
"id": "18775988",
"url": "https://glygen.org/publication/PubMed/18775988"
}
],
"site_lbl": "Ser339"
},
{
"start_pos": 339,
"end_pos": 339,
"kinase_uniprot_canonical_ac": "Q16512-1",
"kinase_gene_name": "PKN1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
}
],
"site_lbl": "Ser339"
},
{
"start_pos": 339,
"end_pos": 339,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by PAK1, PAK2 and PAK3",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "9234708",
"url": "https://glygen.org/publication/PubMed/9234708"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
},
{
"database": "PubMed",
"id": "17428866",
"url": "https://glygen.org/publication/PubMed/17428866"
},
{
"database": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
},
{
"database": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
}
],
"site_lbl": "Ser339"
},
{
"start_pos": 340,
"end_pos": 340,
"kinase_uniprot_canonical_ac": "O60674-1",
"kinase_gene_name": "JAK2",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11134016",
"url": "https://glygen.org/publication/PubMed/11134016"
},
{
"database": "PubMed",
"id": "8876196",
"url": "https://glygen.org/publication/PubMed/8876196"
},
{
"database": "PubMed",
"id": "9689060",
"url": "https://glygen.org/publication/PubMed/9689060"
}
],
"site_lbl": "Tyr340"
},
{
"start_pos": 340,
"end_pos": 340,
"kinase_uniprot_canonical_ac": "P12931-1",
"kinase_gene_name": "SRC",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "17097642",
"url": "https://glygen.org/publication/PubMed/17097642"
},
{
"database": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
},
{
"database": "PubMed",
"id": "10998357",
"url": "https://glygen.org/publication/PubMed/10998357"
},
{
"database": "PubMed",
"id": "7692235",
"url": "https://glygen.org/publication/PubMed/7692235"
}
],
"site_lbl": "Tyr340"
},
{
"start_pos": 340,
"end_pos": 340,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "Phosphotyrosine; by SRC",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11134016",
"url": "https://glygen.org/publication/PubMed/11134016"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
},
{
"database": "PubMed",
"id": "14688280",
"url": "https://glygen.org/publication/PubMed/14688280"
},
{
"database": "PubMed",
"id": "17064357",
"url": "https://glygen.org/publication/PubMed/17064357"
},
{
"database": "PubMed",
"id": "17492661",
"url": "https://glygen.org/publication/PubMed/17492661"
},
{
"database": "PubMed",
"id": "18064632",
"url": "https://glygen.org/publication/PubMed/18064632"
},
{
"database": "PubMed",
"id": "23905676",
"url": "https://glygen.org/publication/PubMed/23905676"
},
{
"database": "PubMed",
"id": "26565813",
"url": "https://glygen.org/publication/PubMed/26565813"
},
{
"database": "PubMed",
"id": "7542586",
"url": "https://glygen.org/publication/PubMed/7542586"
},
{
"database": "PubMed",
"id": "9020159",
"url": "https://glygen.org/publication/PubMed/9020159"
},
{
"database": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
],
"site_lbl": "Tyr340"
},
{
"start_pos": 341,
"end_pos": 341,
"kinase_uniprot_canonical_ac": "O60674-1",
"kinase_gene_name": "JAK2",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
},
{
"database": "PubMed",
"id": "8876196",
"url": "https://glygen.org/publication/PubMed/8876196"
}
],
"site_lbl": "Tyr341"
},
{
"start_pos": 341,
"end_pos": 341,
"kinase_uniprot_canonical_ac": "P12931-1",
"kinase_gene_name": "SRC",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
},
{
"database": "PubMed",
"id": "17097642",
"url": "https://glygen.org/publication/PubMed/17097642"
},
{
"database": "PubMed",
"id": "8876196",
"url": "https://glygen.org/publication/PubMed/8876196"
},
{
"database": "PubMed",
"id": "11376654",
"url": "https://glygen.org/publication/PubMed/11376654"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
}
],
"site_lbl": "Tyr341"
},
{
"start_pos": 341,
"end_pos": 341,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "Phosphotyrosine; by SRC",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
},
{
"database": "PubMed",
"id": "11259591",
"url": "https://glygen.org/publication/PubMed/11259591"
},
{
"database": "PubMed",
"id": "11376654",
"url": "https://glygen.org/publication/PubMed/11376654"
},
{
"database": "PubMed",
"id": "12446733",
"url": "https://glygen.org/publication/PubMed/12446733"
},
{
"database": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
},
{
"database": "PubMed",
"id": "14688280",
"url": "https://glygen.org/publication/PubMed/14688280"
},
{
"database": "PubMed",
"id": "17064357",
"url": "https://glygen.org/publication/PubMed/17064357"
},
{
"database": "PubMed",
"id": "17492661",
"url": "https://glygen.org/publication/PubMed/17492661"
},
{
"database": "PubMed",
"id": "22592532",
"url": "https://glygen.org/publication/PubMed/22592532"
},
{
"database": "PubMed",
"id": "23905676",
"url": "https://glygen.org/publication/PubMed/23905676"
},
{
"database": "PubMed",
"id": "26565813",
"url": "https://glygen.org/publication/PubMed/26565813"
},
{
"database": "PubMed",
"id": "28694330",
"url": "https://glygen.org/publication/PubMed/28694330"
},
{
"database": "PubMed",
"id": "31213532",
"url": "https://glygen.org/publication/PubMed/31213532"
},
{
"database": "PubMed",
"id": "7542586",
"url": "https://glygen.org/publication/PubMed/7542586"
},
{
"database": "PubMed",
"id": "9020159",
"url": "https://glygen.org/publication/PubMed/9020159"
},
{
"database": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
],
"site_lbl": "Tyr341"
},
{
"start_pos": 43,
"end_pos": 43,
"kinase_uniprot_canonical_ac": "P17252-1",
"kinase_gene_name": "PRKCA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "7935389",
"url": "https://glygen.org/publication/PubMed/7935389"
}
],
"site_lbl": "Ser43"
},
{
"start_pos": 43,
"end_pos": 43,
"kinase_uniprot_canonical_ac": "P17612-1",
"kinase_gene_name": "PRKACA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "11997508",
"url": "https://glygen.org/publication/PubMed/11997508"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "PubMed",
"id": "10862777",
"url": "https://glygen.org/publication/PubMed/10862777"
}
],
"site_lbl": "Ser43"
},
{
"start_pos": 43,
"end_pos": 43,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by PKA and MAPK1",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "11027949",
"url": "https://glygen.org/publication/PubMed/11027949"
},
{
"database": "PubMed",
"id": "12801936",
"url": "https://glygen.org/publication/PubMed/12801936"
},
{
"database": "PubMed",
"id": "15280158",
"url": "https://glygen.org/publication/PubMed/15280158"
},
{
"database": "PubMed",
"id": "15899852",
"url": "https://glygen.org/publication/PubMed/15899852"
},
{
"database": "PubMed",
"id": "21734462",
"url": "https://glygen.org/publication/PubMed/21734462"
},
{
"database": "PubMed",
"id": "24853429",
"url": "https://glygen.org/publication/PubMed/24853429"
},
{
"database": "PubMed",
"id": "7694366",
"url": "https://glygen.org/publication/PubMed/7694366"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
},
{
"database": "PubMed",
"id": "8607981",
"url": "https://glygen.org/publication/PubMed/8607981"
},
{
"database": "PubMed",
"id": "9001246",
"url": "https://glygen.org/publication/PubMed/9001246"
},
{
"database": "PubMed",
"id": "9272646",
"url": "https://glygen.org/publication/PubMed/9272646"
}
],
"site_lbl": "Ser43"
},
{
"start_pos": 471,
"end_pos": 471,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "16093354",
"url": "https://glygen.org/publication/PubMed/16093354"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"site_lbl": "Ser471"
},
{
"start_pos": 491,
"end_pos": 491,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "Phosphothreonine",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "11447113",
"url": "https://glygen.org/publication/PubMed/11447113"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "15258589",
"url": "https://glygen.org/publication/PubMed/15258589"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
}
],
"site_lbl": "Thr491"
},
{
"start_pos": 494,
"end_pos": 494,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "11447113",
"url": "https://glygen.org/publication/PubMed/11447113"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "15258589",
"url": "https://glygen.org/publication/PubMed/15258589"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
}
],
"site_lbl": "Ser494"
},
{
"start_pos": 497,
"end_pos": 497,
"kinase_uniprot_canonical_ac": "P05129-1",
"kinase_gene_name": "PRKCG",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
}
],
"site_lbl": "Ser497"
},
{
"start_pos": 497,
"end_pos": 497,
"kinase_uniprot_canonical_ac": "P05771-1",
"kinase_gene_name": "PRKCB",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
}
],
"site_lbl": "Ser497"
},
{
"start_pos": 497,
"end_pos": 497,
"kinase_uniprot_canonical_ac": "P17252-1",
"kinase_gene_name": "PRKCA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
},
{
"database": "PubMed",
"id": "12551925",
"url": "https://glygen.org/publication/PubMed/12551925"
}
],
"site_lbl": "Ser497"
},
{
"start_pos": 497,
"end_pos": 497,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
}
],
"site_lbl": "Ser497"
},
{
"start_pos": 499,
"end_pos": 499,
"kinase_uniprot_canonical_ac": "P17252-1",
"kinase_gene_name": "PRKCA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8321321",
"url": "https://glygen.org/publication/PubMed/8321321"
},
{
"database": "PubMed",
"id": "12551925",
"url": "https://glygen.org/publication/PubMed/12551925"
}
],
"site_lbl": "Ser499"
},
{
"start_pos": 499,
"end_pos": 499,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by PKC",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8321321",
"url": "https://glygen.org/publication/PubMed/8321321"
},
{
"database": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
}
],
"site_lbl": "Ser499"
},
{
"start_pos": 619,
"end_pos": 619,
"kinase_uniprot_canonical_ac": "P05129-1",
"kinase_gene_name": "PRKCG",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
}
],
"site_lbl": "Ser619"
},
{
"start_pos": 619,
"end_pos": 619,
"kinase_uniprot_canonical_ac": "P05771-1",
"kinase_gene_name": "PRKCB",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
}
],
"site_lbl": "Ser619"
},
{
"start_pos": 619,
"end_pos": 619,
"kinase_uniprot_canonical_ac": "P17252-1",
"kinase_gene_name": "PRKCA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
},
{
"database": "PubMed",
"id": "12551925",
"url": "https://glygen.org/publication/PubMed/12551925"
}
],
"site_lbl": "Ser619"
},
{
"start_pos": 619,
"end_pos": 619,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser619"
},
{
"start_pos": 621,
"end_pos": 621,
"kinase_uniprot_canonical_ac": "P04049-1",
"kinase_gene_name": "RAF1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "19007248",
"url": "https://glygen.org/publication/PubMed/19007248"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
},
{
"database": "PubMed",
"id": "9091312",
"url": "https://glygen.org/publication/PubMed/9091312"
},
{
"database": "PubMed",
"id": "9710607",
"url": "https://glygen.org/publication/PubMed/9710607"
}
],
"site_lbl": "Ser621"
},
{
"start_pos": 621,
"end_pos": 621,
"kinase_uniprot_canonical_ac": "P17612-1",
"kinase_gene_name": "PRKACA",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "19007248",
"url": "https://glygen.org/publication/PubMed/19007248"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
},
{
"database": "PubMed",
"id": "9091312",
"url": "https://glygen.org/publication/PubMed/9091312"
},
{
"database": "PubMed",
"id": "9710607",
"url": "https://glygen.org/publication/PubMed/9710607"
}
],
"site_lbl": "Ser621"
},
{
"start_pos": 621,
"end_pos": 621,
"kinase_uniprot_canonical_ac": "Q13131-1",
"kinase_gene_name": "PRKAA1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PubMed",
"id": "19007248",
"url": "https://glygen.org/publication/PubMed/19007248"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
},
{
"database": "PubMed",
"id": "9091312",
"url": "https://glygen.org/publication/PubMed/9091312"
},
{
"database": "PubMed",
"id": "9710607",
"url": "https://glygen.org/publication/PubMed/9710607"
}
],
"site_lbl": "Ser621"
},
{
"start_pos": 621,
"end_pos": 621,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
},
{
"database": "PubMed",
"id": "10801873",
"url": "https://glygen.org/publication/PubMed/10801873"
},
{
"database": "IntAct",
"id": "P04049",
"url": "https://www.ebi.ac.uk/intact/interactors/id:P04049*"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "24330068",
"url": "https://glygen.org/publication/PubMed/24330068"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "PubMed",
"id": "9091312",
"url": "https://glygen.org/publication/PubMed/9091312"
},
{
"database": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "14688280",
"url": "https://glygen.org/publication/PubMed/14688280"
},
{
"database": "PubMed",
"id": "11041243",
"url": "https://glygen.org/publication/PubMed/11041243"
},
{
"database": "PubMed",
"id": "19298812",
"url": "https://glygen.org/publication/PubMed/19298812"
},
{
"database": "PubMed",
"id": "19595761",
"url": "https://glygen.org/publication/PubMed/19595761"
},
{
"database": "PubMed",
"id": "22182854",
"url": "https://glygen.org/publication/PubMed/22182854"
},
{
"database": "PubMed",
"id": "23554907",
"url": "https://glygen.org/publication/PubMed/23554907"
},
{
"database": "PubMed",
"id": "24922062",
"url": "https://glygen.org/publication/PubMed/24922062"
},
{
"database": "PubMed",
"id": "26295714",
"url": "https://glygen.org/publication/PubMed/26295714"
},
{
"database": "PubMed",
"id": "27003818",
"url": "https://glygen.org/publication/PubMed/27003818"
},
{
"database": "PubMed",
"id": "27331409",
"url": "https://glygen.org/publication/PubMed/27331409"
},
{
"database": "PubMed",
"id": "29515772",
"url": "https://glygen.org/publication/PubMed/29515772"
}
],
"site_lbl": "Ser621"
},
{
"start_pos": 624,
"end_pos": 624,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser624"
},
{
"start_pos": 641,
"end_pos": 641,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
],
"site_lbl": "Thr641"
},
{
"start_pos": 642,
"end_pos": 642,
"kinase_uniprot_canonical_ac": "P28482-1",
"kinase_gene_name": "MAPK1",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "18767875",
"url": "https://glygen.org/publication/PubMed/18767875"
}
],
"site_lbl": "Ser642"
},
{
"start_pos": 642,
"end_pos": 642,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine; by MAPK1",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "phospho.ELM",
"id": "P04049",
"url": "http://phospho.elm.eu.org/byAccession/P04049.html"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PRO",
"id": "P04049",
"url": "http://purl.obolibrary.org/obo/P04049"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
}
],
"site_lbl": "Ser642"
}
],
"glycation": [],
"keywords": [
"enzyme",
"glycoprotein",
"glycoprotein_reported_with_glycan"
],
"publication": [
{
"title": "Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.",
"journal": "The EMBO journal",
"date": "1999",
"authors": "Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "10205168",
"url": "https://glygen.org/publication/PubMed/10205168"
}
]
},
{
"title": "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "10206983",
"url": "https://glygen.org/publication/PubMed/10206983"
}
]
},
{
"title": "Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.",
"journal": "Current biology : CB",
"date": "1999",
"authors": "Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "10209122",
"url": "https://glygen.org/publication/PubMed/10209122"
}
]
},
{
"title": "Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.",
"journal": "Molecular and cellular biology",
"date": "1999",
"authors": "Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "10409742",
"url": "https://glygen.org/publication/PubMed/10409742"
}
]
},
{
"title": "Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "1999",
"authors": "Oh-hora M, Ogata M, Mori Y, Adachi M, Imai K, Kosugi A, Hamaoka T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "10415025",
"url": "https://glygen.org/publication/PubMed/10415025"
}
]
},
{
"title": "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.",
"journal": "Nature",
"date": "1999",
"authors": "Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "10490027",
"url": "https://glygen.org/publication/PubMed/10490027"
}
]
},
{
"title": "Identification of an acid-activated Cl(-) channel from human skeletal muscles.",
"journal": "The American journal of physiology",
"date": "1999",
"authors": "Kawasaki M, Fukuma T, Yamauchi K, Sakamoto H, Marumo F, Sasaki S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "10564087",
"url": "https://glygen.org/publication/PubMed/10564087"
}
]
},
{
"title": "The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Xu Be, Wilsbacher JL, Collisson T, Cobb MH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10567369",
"url": "https://glygen.org/publication/PubMed/10567369"
}
]
},
{
"title": "Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.",
"journal": "Science (New York, N.Y.)",
"date": "1999",
"authors": "Rommel C, Clarke BA, Zimmermann S, Nunez L, Rossman R, Reid K, Moelling K, Yancopoulos GD, Glass DJ",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "10576741",
"url": "https://glygen.org/publication/PubMed/10576741"
}
]
},
{
"title": "Phosphorylation and regulation of Raf by Akt (protein kinase B).",
"journal": "Science (New York, N.Y.)",
"date": "1999",
"authors": "Zimmermann S, Moelling K",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "10576742",
"url": "https://glygen.org/publication/PubMed/10576742"
}
]
},
{
"title": "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V.",
"journal": "Blood",
"date": "2000",
"authors": "Feng S, Christodoulides N, Resendiz JC, Berndt MC, Kroll MH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "10627461",
"url": "https://glygen.org/publication/PubMed/10627461"
}
]
},
{
"title": "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits.",
"journal": "The Biochemical journal",
"date": "2000",
"authors": "Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "10642508",
"url": "https://glygen.org/publication/PubMed/10642508"
}
]
},
{
"title": "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP.",
"journal": "Oncogene",
"date": "2000",
"authors": "Pettiford SM, Herbst R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "10702794",
"url": "https://glygen.org/publication/PubMed/10702794"
}
]
},
{
"title": "Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak.",
"journal": "Current biology : CB",
"date": "2000",
"authors": "Sun H, King AJ, Diaz HB, Marshall MS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "10712905",
"url": "https://glygen.org/publication/PubMed/10712905"
}
]
},
{
"title": "Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.",
"journal": "Kidney international",
"date": "2000",
"authors": "Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "10720933",
"url": "https://glygen.org/publication/PubMed/10720933"
}
]
},
{
"title": "Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.",
"journal": "Cell",
"date": "2000",
"authors": "Geijtenbeek TB, Torensma R, van Vliet SJ, van Duijnhoven GC, Adema GJ, van Kooyk Y, Figdor CG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "10721994",
"url": "https://glygen.org/publication/PubMed/10721994"
}
]
},
{
"title": "beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.",
"journal": "The Journal of cell biology",
"date": "2000",
"authors": "DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, Bunnett NW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "10725339",
"url": "https://glygen.org/publication/PubMed/10725339"
}
]
},
{
"title": "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.",
"journal": "Molecular and cellular biology",
"date": "2000",
"authors": "Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "10757792",
"url": "https://glygen.org/publication/PubMed/10757792"
}
]
},
{
"title": "Molecular cloning, functional expression and chromosomal localization of an amiloride-sensitive Na(+) channel from human small intestine.",
"journal": "FEBS letters",
"date": "2000",
"authors": "Schaefer L, Sakai H, Mattei M, Lazdunski M, Lingueglia E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "10767424",
"url": "https://glygen.org/publication/PubMed/10767424"
}
]
},
{
"title": "Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338.",
"journal": "Current biology : CB",
"date": "2000",
"authors": "Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "10801448",
"url": "https://glygen.org/publication/PubMed/10801448"
}
]
},
{
"title": "Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.",
"journal": "The Journal of biological chemistry",
"date": "2000",
"authors": "Abraham D, Podar K, Pacher M, Kubicek M, Welzel N, Hemmings BA, Dilworth SM, Mischak H, Kolch W, Baccarini M",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "10801873",
"url": "https://glygen.org/publication/PubMed/10801873"
}
]
},
{
"title": "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.",
"journal": "Cell",
"date": "2000",
"authors": "Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "10830164",
"url": "https://glygen.org/publication/PubMed/10830164"
}
]
},
{
"title": "Functional and structural analysis of ClC-K chloride channels involved in renal disease.",
"journal": "The Journal of biological chemistry",
"date": "2000",
"authors": "Waldegger S, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "10831588",
"url": "https://glygen.org/publication/PubMed/10831588"
}
]
},
{
"title": "Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase.",
"journal": "The Journal of biological chemistry",
"date": "2000",
"authors": "Sidovar MF, Kozlowski P, Lee JW, Collins MA, He Y, Graves LM",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "10862777",
"url": "https://glygen.org/publication/PubMed/10862777"
}
]
},
{
"title": "Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3zeta.",
"journal": "Blood",
"date": "2000",
"authors": "Munday AD, Berndt MC, Mitchell CA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "10887121",
"url": "https://glygen.org/publication/PubMed/10887121"
}
]
},
{
"title": "Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling.",
"journal": "Molecular and cellular biology",
"date": "2000",
"authors": "Muller J, Cacace AM, Lyons WE, McGill CB, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "10891492",
"url": "https://glygen.org/publication/PubMed/10891492"
}
]
},
{
"title": "Regulation of the Raf-1 kinase domain by phosphorylation and 14-3-3 association.",
"journal": "The Biochemical journal",
"date": "2000",
"authors": "Yip-Schneider MT, Miao W, Lin A, Barnard DS, Tzivion G, Marshall MS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "10998357",
"url": "https://glygen.org/publication/PubMed/10998357"
}
]
},
{
"title": "DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking.",
"journal": "Nature immunology",
"date": "2000",
"authors": "Geijtenbeek TB, Krooshoop DJ, Bleijs DA, van Vliet SJ, van Duijnhoven GC, Grabovsky V, Alon R, Figdor CG, van Kooyk Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "11017109",
"url": "https://glygen.org/publication/PubMed/11017109"
}
]
},
{
"title": "cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway.",
"journal": "Cellular signalling",
"date": "2000",
"authors": "Ramstad C, Sundvold V, Johansen HK, Lea T",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11027949",
"url": "https://glygen.org/publication/PubMed/11027949"
}
]
},
{
"title": "Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.",
"journal": "The EMBO journal",
"date": "2000",
"authors": "Zhang BH, Guan KL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "11032810",
"url": "https://glygen.org/publication/PubMed/11032810"
}
]
},
{
"title": "Detection of kinases that phosphorylate 14-3-3 binding sites of Raf-1 using in situ gel kinase assay.",
"journal": "Biological & pharmaceutical bulletin",
"date": "2000",
"authors": "Kinuya M, Takishima K, Mamiya G",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11041243",
"url": "https://glygen.org/publication/PubMed/11041243"
}
]
},
{
"title": "Kinase suppressor of Ras signals through Thr269 of c-Raf-1.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Xing HR, Kolesnick R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "11134016",
"url": "https://glygen.org/publication/PubMed/11134016"
}
]
},
{
"title": "Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus.",
"journal": "Neuron",
"date": "2001",
"authors": "Stobrawa SM, Breiderhoff T, Takamori S, Engel D, Schweizer M, Zdebik AA, Bosl MR, Ruether K, Jahn H, Draguhn A, Jahn R, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11182090",
"url": "https://glygen.org/publication/PubMed/11182090"
}
]
},
{
"title": "S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.",
"journal": "Molecular and cellular biology",
"date": "2001",
"authors": "Chiloeches A, Mason CS, Marais R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11259591",
"url": "https://glygen.org/publication/PubMed/11259591"
}
]
},
{
"title": "Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Zang M, Waelde CA, Xiang X, Rana A, Wen R, Luo Z",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11274179",
"url": "https://glygen.org/publication/PubMed/11274179"
}
]
},
{
"title": "Active Ras induces heterodimerization of cRaf and BRaf.",
"journal": "Cancer research",
"date": "2001",
"authors": "Weber CK, Slupsky JR, Kalmes HA, Rapp UR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "11325826",
"url": "https://glygen.org/publication/PubMed/11325826"
}
]
},
{
"title": "Nongenomic estrogen action in human lung myofibroblasts.",
"journal": "Biochemical and biophysical research communications",
"date": "2001",
"authors": "Flores-Delgado G, Bringas P, Buckley S, Anderson KD, Warburton D",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11341776",
"url": "https://glygen.org/publication/PubMed/11341776"
}
]
},
{
"title": "Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src.",
"journal": "FEBS letters",
"date": "2001",
"authors": "King AJ, Wireman RS, Hamilton M, Marshall MS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11376654",
"url": "https://glygen.org/publication/PubMed/11376654"
}
]
},
{
"title": "Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2001-07-03",
"authors": "Chen J, Fujii K, Zhang L, Roberts T, Fu H",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11427728",
"url": "https://glygen.org/publication/PubMed/11427728"
}
]
},
{
"title": "Positive and negative regulation of Raf kinase activity and function by phosphorylation.",
"journal": "The EMBO journal",
"date": "2001",
"authors": "Chong H, Lee J, Guan KL",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "11447113",
"url": "https://glygen.org/publication/PubMed/11447113"
}
]
},
{
"title": "Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions.",
"journal": "Oncogene",
"date": "2001",
"authors": "Jaumot M, Hancock JF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "11494123",
"url": "https://glygen.org/publication/PubMed/11494123"
}
]
},
{
"title": "Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.",
"journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
"date": "2001",
"authors": "Voilley N, de Weille J, Mamet J, Lazdunski M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11588175",
"url": "https://glygen.org/publication/PubMed/11588175"
}
]
},
{
"title": "Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure.",
"journal": "Nature genetics",
"date": "2001",
"authors": "Birkenhager R, Otto E, Schurmann MJ, Vollmer M, Ruf EM, Maier-Lutz I, Beekmann F, Fekete A, Omran H, Feldmann D, Milford DV, Jeck N, Konrad M, Landau D, Knoers NV, Antignac C, Sudbrak R, Kispert A, Hildebrandt F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11687798",
"url": "https://glygen.org/publication/PubMed/11687798"
}
]
},
{
"title": "Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Williamson D, Pikovski I, Cranmer SL, Mangin P, Mistry N, Domagala T, Chehab S, Lanza F, Salem HH, Jackson SP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "11700320",
"url": "https://glygen.org/publication/PubMed/11700320"
}
]
},
{
"title": "Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Broustas CG, Grammatikakis N, Eto M, Dent P, Brautigan DL, Kasid U",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11719507",
"url": "https://glygen.org/publication/PubMed/11719507"
}
]
},
{
"title": "Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Zang M, Hayne C, Luo Z",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "11733498",
"url": "https://glygen.org/publication/PubMed/11733498"
}
]
},
{
"title": "Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.",
"journal": "Nature",
"date": "2001",
"authors": "Estevez R, Boettger T, Stein V, Birkenhager R, Otto E, Hildebrandt F, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11734858",
"url": "https://glygen.org/publication/PubMed/11734858"
}
]
},
{
"title": "C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.",
"journal": "Molecular cell",
"date": "2001",
"authors": "Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "11741534",
"url": "https://glygen.org/publication/PubMed/11741534"
}
]
},
{
"title": "Dephosphorylation of Ser-259 regulates Raf-1 membrane association.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Kubicek M, Pacher M, Abraham D, Podar K, Eulitz M, Baccarini M",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11756411",
"url": "https://glygen.org/publication/PubMed/11756411"
}
]
},
{
"title": "Regulation of Raf-1 activation and signalling by dephosphorylation.",
"journal": "The EMBO journal",
"date": "2002",
"authors": "Dhillon AS, Meikle S, Yazici Z, Eulitz M, Kolch W",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11782426",
"url": "https://glygen.org/publication/PubMed/11782426"
}
]
},
{
"title": "The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.",
"journal": "Mol. Cell. Biol.",
"date": "2002",
"authors": "Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, Colicelli J",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "11784866",
"url": "https://glygen.org/publication/PubMed/11784866"
}
]
},
{
"title": "Identification of Sef, a novel modulator of FGF signalling.",
"journal": "Nature cell biology",
"date": "2002",
"authors": "Tsang M, Friesel R, Kudoh T, Dawid IB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "11802164",
"url": "https://glygen.org/publication/PubMed/11802164"
}
]
},
{
"title": "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.",
"journal": "Nature cell biology",
"date": "2002",
"authors": "Furthauer M, Lin W, Ang SL, Thisse B, Thisse C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "11802165",
"url": "https://glygen.org/publication/PubMed/11802165"
}
]
},
{
"title": "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.",
"journal": "The Journal of allergy and clinical immunology",
"date": "2002",
"authors": "Toda M, Tulic MK, Levitt RC, Hamid Q",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11842292",
"url": "https://glygen.org/publication/PubMed/11842292"
}
]
},
{
"title": "The vitelliform macular dystrophy protein defines a new family of chloride channels.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2002",
"authors": "Sun H, Tsunenari T, Yau KW, Nathans J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11904445",
"url": "https://glygen.org/publication/PubMed/11904445"
}
]
},
{
"title": "Increased expression of the human Ca2+-activated Cl- channel 1 (CaCC1) gene in the asthmatic airway.",
"journal": "American journal of respiratory and critical care medicine",
"date": "2002",
"authors": "Hoshino M, Morita S, Iwashita H, Sagiya Y, Nagi T, Nakanishi A, Ashida Y, Nishimura O, Fujisawa Y, Fujino M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "11956057",
"url": "https://glygen.org/publication/PubMed/11956057"
}
]
},
{
"title": "Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.",
"journal": "Molecular and cellular biology",
"date": "2002",
"authors": "Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "11971957",
"url": "https://glygen.org/publication/PubMed/11971957"
}
]
},
{
"title": "Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms.",
"journal": "Molecular and cellular biology",
"date": "2002",
"authors": "Dumaz N, Light Y, Marais R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "11997508",
"url": "https://glygen.org/publication/PubMed/11997508"
}
]
},
{
"title": "Mutations of the BRAF gene in human cancer.",
"journal": "Nature",
"date": "2002",
"authors": "Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "12068308",
"url": "https://glygen.org/publication/PubMed/12068308"
}
]
},
{
"title": "Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.",
"journal": "Experimental cell research",
"date": "2002",
"authors": "Huang WC, Chio CC, Chi KH, Wu HM, Lin WW",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12083801",
"url": "https://glygen.org/publication/PubMed/12083801"
}
]
},
{
"title": "Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Mabuchi S, Ohmichi M, Kimura A, Hisamoto K, Hayakawa J, Nishio Y, Adachi K, Takahashi K, Arimoto-Ishida E, Nakatsuji Y, Tasaka K, Murata Y",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12087097",
"url": "https://glygen.org/publication/PubMed/12087097"
}
]
},
{
"title": "Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.",
"journal": "Cell death and differentiation",
"date": "2002",
"authors": "Brognard J, Dennis PA",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12181740",
"url": "https://glygen.org/publication/PubMed/12181740"
}
]
},
{
"title": "Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.",
"journal": "American journal of physiology. Cell physiology",
"date": "2002",
"authors": "Gosmanov AR, Wong JA, Thomason DB",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12225966",
"url": "https://glygen.org/publication/PubMed/12225966"
}
]
},
{
"title": "Phosphorylation of 338SSYY341 regulates specific interaction between Raf-1 and MEK1.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Xiang X, Zang M, Waelde CA, Wen R, Luo Z",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "12244094",
"url": "https://glygen.org/publication/PubMed/12244094"
}
]
},
{
"title": "Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.",
"journal": "The Journal of clinical investigation",
"date": "2002",
"authors": "Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "12393854",
"url": "https://glygen.org/publication/PubMed/12393854"
}
]
},
{
"title": "The requirement of specific membrane domains for Raf-1 phosphorylation and activation.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Carey KD, Watson RT, Pessin JE, Stork PJ",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12446733",
"url": "https://glygen.org/publication/PubMed/12446733"
}
]
},
{
"title": "Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.",
"journal": "The EMBO journal",
"date": "2002",
"authors": "Chen LF, Mu Y, Greene WC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "12456660",
"url": "https://glygen.org/publication/PubMed/12456660"
}
]
},
{
"title": "The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "12473660",
"url": "https://glygen.org/publication/PubMed/12473660"
}
]
},
{
"title": "Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.",
"journal": "Developmental cell",
"date": "2002",
"authors": "Teis D, Wunderlich W, Huber LA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "12479806",
"url": "https://glygen.org/publication/PubMed/12479806"
}
]
},
{
"title": "Mycobacteria target DC-SIGN to suppress dendritic cell function.",
"journal": "The Journal of experimental medicine",
"date": "2003",
"authors": "Geijtenbeek TB, Van Vliet SJ, Koppel EA, Sanchez-Hernandez M, Vandenbroucke-Grauls CM, Appelmelk B, Van Kooyk Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "12515809",
"url": "https://glygen.org/publication/PubMed/12515809"
}
]
},
{
"title": "Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Tran NH, Frost JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "12551923",
"url": "https://glygen.org/publication/PubMed/12551923"
}
]
},
{
"title": "Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Corbit KC, Trakul N, Eves EM, Diaz B, Marshall M, Rosner MR",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12551925",
"url": "https://glygen.org/publication/PubMed/12551925"
}
]
},
{
"title": "Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents.",
"journal": "The Biochemical journal",
"date": "2003",
"authors": "Munoz JJ, Tarrega C, Blanco-Aparicio C, Pulido R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "12583813",
"url": "https://glygen.org/publication/PubMed/12583813"
}
]
},
{
"title": "Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).",
"journal": "The EMBO journal",
"date": "2003",
"authors": "Vermeulen L, De Wilde G, Van Damme P, Vanden Berghe W, Haegeman G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "12628924",
"url": "https://glygen.org/publication/PubMed/12628924"
}
]
},
{
"title": "A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling.",
"journal": "The Biochemical journal",
"date": "2003",
"authors": "Hatakeyama M, Kimura S, Naka T, Kawasaki T, Yumoto N, Ichikawa M, Kim JH, Saito K, Saeki M, Shirouzu M, Yokoyama S, Konagaya A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12691603",
"url": "https://glygen.org/publication/PubMed/12691603"
}
]
},
{
"title": "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.",
"journal": "Nat. Cell Biol.",
"date": "2003",
"authors": "Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12717443",
"url": "https://glygen.org/publication/PubMed/12717443"
}
]
},
{
"title": "Role of the serine-threonine kinase PAK-1 in myxoma virus replication.",
"journal": "Journal of virology",
"date": "2003",
"authors": "Johnston JB, Barrett JW, Chang W, Chung CS, Zeng W, Masters J, Mann M, Wang F, Cao J, McFadden G",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12719581",
"url": "https://glygen.org/publication/PubMed/12719581"
}
]
},
{
"title": "Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Dumaz N, Marais R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "12801936",
"url": "https://glygen.org/publication/PubMed/12801936"
}
]
},
{
"title": "Mek2 is dispensable for mouse growth and development.",
"journal": "Molecular and cellular biology",
"date": "2003",
"authors": "Belanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "12832465",
"url": "https://glygen.org/publication/PubMed/12832465"
}
]
},
{
"title": "Structure-function analysis of the bestrophin family of anion channels.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Tsunenari T, Sun H, Williams J, Cahill H, Smallwood P, Yau KW, Nathans J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "12907679",
"url": "https://glygen.org/publication/PubMed/12907679"
}
]
},
{
"title": "Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.",
"journal": "Current biology : CB",
"date": "2003",
"authors": "Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "12932319",
"url": "https://glygen.org/publication/PubMed/12932319"
}
]
},
{
"title": "Ras signaling: PP2A puts Ksr and Raf in the right place.",
"journal": "Current biology : CB",
"date": "2003",
"authors": "Raabe T, Rapp UR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "12932339",
"url": "https://glygen.org/publication/PubMed/12932339"
}
]
},
{
"title": "The skeletal muscle chloride channel in dominant and recessive human myotonia.",
"journal": "Science (New York, N.Y.)",
"date": "1992",
"authors": "Koch MC, Steinmeyer K, Lorenz C, Ricker K, Wolf F, Otto M, Zoll B, Lehmann-Horn F, Grzeschik KH, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "1379744",
"url": "https://glygen.org/publication/PubMed/1379744"
}
]
},
{
"title": "Membrane localization, oligomerization, and phosphorylation are required for optimal raf activation.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Goetz CA, O'Neil JJ, Farrar MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "14530258",
"url": "https://glygen.org/publication/PubMed/14530258"
}
]
},
{
"title": "Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis.",
"journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research",
"date": "2003",
"authors": "Frattini A, Pangrazio A, Susani L, Sobacchi C, Mirolo M, Abinun M, Andolina M, Flanagan A, Horwitz EM, Mihci E, Notarangelo LD, Ramenghi U, Teti A, Van Hove J, Vujic D, Young T, Albertini A, Orchard PJ, Vezzoni P, Villa A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "14584882",
"url": "https://glygen.org/publication/PubMed/14584882"
}
]
},
{
"title": "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility.",
"journal": "Nature cell biology",
"date": "2003",
"authors": "Wang D, King SM, Quill TA, Doolittle LK, Garbers DL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "14634667",
"url": "https://glygen.org/publication/PubMed/14634667"
}
]
},
{
"title": "Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.",
"journal": "Molecular cell",
"date": "2003",
"authors": "Ishibe S, Joly D, Zhu X, Cantley LG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "14636584",
"url": "https://glygen.org/publication/PubMed/14636584"
}
]
},
{
"title": "Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf.",
"journal": "Oncogene",
"date": "2003",
"authors": "Brummer T, Naegele H, Reth M, Misawa Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674499"
}
],
"reference": [
{
"type": "PubMed",
"id": "14654779",
"url": "https://glygen.org/publication/PubMed/14654779"
}
]
},
{
"title": "Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Hekman M, Wiese S, Metz R, Albert S, Troppmair J, Nickel J, Sendtner M, Rapp UR",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "14688280",
"url": "https://glygen.org/publication/PubMed/14688280"
}
]
},
{
"title": "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.",
"journal": "Nature",
"date": "2004",
"authors": "Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "14724641",
"url": "https://glygen.org/publication/PubMed/14724641"
}
]
},
{
"title": "Kinase suppressor of RAS (KSR) amplifies the differentiation signal provided by low concentrations 1,25-dihydroxyvitamin D3.",
"journal": "Journal of cellular physiology",
"date": "2004",
"authors": "Wang X, Studzinski GP",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "14755538",
"url": "https://glygen.org/publication/PubMed/14755538"
}
]
},
{
"title": "IQGAP1 binds ERK2 and modulates its activity.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Roy M, Li Z, Sacks DB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "14970219",
"url": "https://glygen.org/publication/PubMed/14970219"
}
]
},
{
"title": "Role of cyclins in cAMP inhibition of glomerular mesangial cell proliferation.",
"journal": "Clinical science (London, England : 1979)",
"date": "2004",
"authors": "Ito C, Yamamoto H, Furukawa Y, Takeda S, Akimoto T, Iimura O, Ando Y, Asano Y, Kusano E",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "14992682",
"url": "https://glygen.org/publication/PubMed/14992682"
}
]
},
{
"title": "A novel human Cl(-) channel family related to Drosophila flightless locus.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Suzuki M, Mizuno A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15010458",
"url": "https://glygen.org/publication/PubMed/15010458"
}
]
},
{
"title": "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.",
"journal": "Cell",
"date": "2004",
"authors": "Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "15035987",
"url": "https://glygen.org/publication/PubMed/15035987"
}
]
},
{
"title": "Salt wasting and deafness resulting from mutations in two chloride channels.",
"journal": "The New England journal of medicine",
"date": "2004",
"authors": "Schlingmann KP, Konrad M, Jeck N, Waldegger P, Reinalter SC, Holder M, Seyberth HW, Waldegger S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15044642",
"url": "https://glygen.org/publication/PubMed/15044642"
}
]
},
{
"title": "LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15047712",
"url": "https://glygen.org/publication/PubMed/15047712"
}
]
},
{
"title": "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2004",
"authors": "Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "15118098",
"url": "https://glygen.org/publication/PubMed/15118098"
}
]
},
{
"title": "CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.",
"journal": "The international journal of biochemistry & cell biology",
"date": "2004",
"authors": "Board PG, Coggan M, Watson S, Gage PW, Dulhunty AF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15147738",
"url": "https://glygen.org/publication/PubMed/15147738"
}
]
},
{
"title": "Sef is a spatial regulator for Ras/MAP kinase signaling.",
"journal": "Developmental cell",
"date": "2004",
"authors": "Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "15239952",
"url": "https://glygen.org/publication/PubMed/15239952"
}
]
},
{
"title": "MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.",
"journal": "Nature cell biology",
"date": "2004",
"authors": "Chadee DN, Kyriakis JM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15258589",
"url": "https://glygen.org/publication/PubMed/15258589"
}
]
},
{
"title": "Sef: a MEK/ERK catcher on the Golgi.",
"journal": "Molecular cell",
"date": "2004",
"authors": "Philips MR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "15260967",
"url": "https://glygen.org/publication/PubMed/15260967"
}
]
},
{
"title": "Differential regulation of mesangial cell mitogenesis by cAMP phosphodiesterase isozymes 3 and 4.",
"journal": "American journal of physiology. Renal physiology",
"date": "2004",
"authors": "Cheng J, Thompson MA, Walker HJ, Gray CE, Diaz Encarnacion MM, Warner GM, Grande JP",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15280158",
"url": "https://glygen.org/publication/PubMed/15280158"
}
]
},
{
"title": "Association of the hCLCA1 gene with childhood and adult asthma.",
"journal": "Genes and immunity",
"date": "2004",
"authors": "Kamada F, Suzuki Y, Shao C, Tamari M, Hasegawa K, Hirota T, Shimizu M, Takahashi N, Mao XQ, Doi S, Fujiwara H, Miyatake A, Fujita K, Chiba Y, Aoki Y, Kure S, Tamura G, Shirakawa T, Matsubara Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15318163",
"url": "https://glygen.org/publication/PubMed/15318163"
}
]
},
{
"title": "Raf kinase activation of adenylyl cyclases: isoform-selective regulation.",
"journal": "Molecular pharmacology",
"date": "2004",
"authors": "Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15385642",
"url": "https://glygen.org/publication/PubMed/15385642"
}
]
},
{
"title": "A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.",
"journal": "Cell cycle (Georgetown, Tex.)",
"date": "2004",
"authors": "Chadee DN, Kyriakis JM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "15467451",
"url": "https://glygen.org/publication/PubMed/15467451"
}
]
},
{
"title": "Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2004",
"authors": "Chen BC, Yu CC, Lei HC, Chang MS, Hsu MJ, Huang CL, Chen MC, Sheu JR, Chen TF, Chen TL, Inoue H, Lin CH",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15470067",
"url": "https://glygen.org/publication/PubMed/15470067"
}
]
},
{
"title": "ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15504734",
"url": "https://glygen.org/publication/PubMed/15504734"
}
]
},
{
"title": "NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic.",
"journal": "Journal of inherited metabolic disease",
"date": "2004",
"authors": "Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, Verheijen F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15505377",
"url": "https://glygen.org/publication/PubMed/15505377"
}
]
},
{
"title": "The RAF proteins take centre stage.",
"journal": "Nature reviews. Molecular cell biology",
"date": "2004",
"authors": "Wellbrock C, Karasarides M, Marais R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "15520807",
"url": "https://glygen.org/publication/PubMed/15520807"
}
]
},
{
"title": "Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway.",
"journal": "Journal of cellular physiology",
"date": "2005",
"authors": "Wang Z, Wang M, Carr BI",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15534860",
"url": "https://glygen.org/publication/PubMed/15534860"
}
]
},
{
"title": "Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.",
"journal": "Nature structural & molecular biology",
"date": "2004",
"authors": "Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "15543157",
"url": "https://glygen.org/publication/PubMed/15543157"
}
]
},
{
"title": "MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling.",
"journal": "Journal of cellular biochemistry",
"date": "2005",
"authors": "Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "15547943",
"url": "https://glygen.org/publication/PubMed/15547943"
}
]
},
{
"title": "SDF-1 synergistically enhances IL-3-induced activation of the Raf-1/MEK/Erk signaling pathway through activation of Rac and its effector Pak kinases to promote hematopoiesis and chemotaxis.",
"journal": "Cellular signalling",
"date": "2005",
"authors": "Arai A, Jin A, Yan W, Mizuchi D, Yamamoto K, Nanki T, Miura O",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15601627",
"url": "https://glygen.org/publication/PubMed/15601627"
}
]
},
{
"title": "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.",
"journal": "Science (New York, N.Y.)",
"date": "2004",
"authors": "O'Neill E, Rushworth L, Baccarini M, Kolch W",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15618521",
"url": "https://glygen.org/publication/PubMed/15618521"
}
]
},
{
"title": "Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.",
"journal": "The Journal of clinical investigation",
"date": "2005",
"authors": "Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA, Nikiforov YE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "15630448",
"url": "https://glygen.org/publication/PubMed/15630448"
}
]
},
{
"title": "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets.",
"journal": "Blood",
"date": "2005",
"authors": "Schultess J, Danielewski O, Smolenski AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "15632203",
"url": "https://glygen.org/publication/PubMed/15632203"
}
]
},
{
"title": "Novel C-Raf phosphorylation sites: serine 296 and 301 participate in Raf regulation.",
"journal": "FEBS letters",
"date": "2005",
"authors": "Hekman M, Fischer A, Wennogle LP, Wang YK, Campbell SL, Rapp UR",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15642359",
"url": "https://glygen.org/publication/PubMed/15642359"
}
]
},
{
"title": "Regulation of Raf-1 by direct feedback phosphorylation.",
"journal": "Molecular cell",
"date": "2005",
"authors": "Dougherty MK, Muller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674499"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "15664191",
"url": "https://glygen.org/publication/PubMed/15664191"
}
]
},
{
"title": "Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo.",
"journal": "Carcinogenesis",
"date": "2005",
"authors": "Liao CH, Pan SL, Guh JH, Chang YL, Pai HC, Lin CH, Teng CM",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15705600",
"url": "https://glygen.org/publication/PubMed/15705600"
}
]
},
{
"title": "B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Tran NH, Wu X, Frost JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "15710605",
"url": "https://glygen.org/publication/PubMed/15710605"
}
]
},
{
"title": "Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase.",
"journal": "EMBO reports",
"date": "2005",
"authors": "Terai K, Matsuda M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "15711535",
"url": "https://glygen.org/publication/PubMed/15711535"
}
]
},
{
"title": "Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway.",
"journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
"date": "2005",
"authors": "Subramaniam S, Shahani N, Strelau J, Laliberte C, Brandt R, Kaplan D, Unsicker K",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15772344",
"url": "https://glygen.org/publication/PubMed/15772344"
}
]
},
{
"title": "p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Jin S, Zhuo Y, Guo W, Field J",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
}
]
},
{
"title": "Essential role of p38gamma in K-Ras transformation independent of phosphorylation.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Tang J, Qi X, Mercola D, Han J, Chen G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "15851477",
"url": "https://glygen.org/publication/PubMed/15851477"
}
]
},
{
"title": "Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor.",
"journal": "Molecular and cellular biology",
"date": "2005",
"authors": "Edin ML, Juliano RL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15899852",
"url": "https://glygen.org/publication/PubMed/15899852"
}
]
},
{
"title": "A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.",
"journal": "The Biochemical journal",
"date": "2005",
"authors": "Dulhunty AF, Pouliquin P, Coggan M, Gage PW, Board PG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15916532",
"url": "https://glygen.org/publication/PubMed/15916532"
}
]
},
{
"title": "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Gibson A, Lewis AP, Affleck K, Aitken AJ, Meldrum E, Thompson N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "15919655",
"url": "https://glygen.org/publication/PubMed/15919655"
}
]
},
{
"title": "Raf-1 is a binding partner of DSCR1.",
"journal": "Arch. Biochem. Biophys.",
"date": "2005",
"authors": "Cho Young-Jin, Abe Mayumi, Kim Seong Yun, Sato Yasufumi",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15935327",
"url": "https://glygen.org/publication/PubMed/15935327"
}
]
},
{
"title": "Second nature: biological functions of the Raf-1 'kinase'.",
"journal": "FEBS Lett.",
"date": "2005",
"authors": "Baccarini Manuela",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "15943972",
"url": "https://glygen.org/publication/PubMed/15943972"
}
]
},
{
"title": "Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.",
"journal": "Nature cell biology",
"date": "2005",
"authors": "Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "16041367",
"url": "https://glygen.org/publication/PubMed/16041367"
}
]
},
{
"title": "Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.",
"journal": "Molecular biology of the cell",
"date": "2005",
"authors": "Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16093354",
"url": "https://glygen.org/publication/PubMed/16093354"
}
]
},
{
"title": "Platelet GPIb-IX-V-dependent signaling.",
"journal": "Journal of thrombosis and haemostasis : JTH",
"date": "2005",
"authors": "Ozaki Y, Asazuma N, Suzuki-Inoue K, Berndt MC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "16102041",
"url": "https://glygen.org/publication/PubMed/16102041"
}
]
},
{
"title": "Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Beeser A, Jaffer ZM, Hofmann C, Chernoff J",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16129686",
"url": "https://glygen.org/publication/PubMed/16129686"
}
]
},
{
"title": "IQGAP1 is a scaffold for mitogen-activated protein kinase signaling.",
"journal": "Molecular and cellular biology",
"date": "2005",
"authors": "Roy M, Li Z, Sacks DB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "16135787",
"url": "https://glygen.org/publication/PubMed/16135787"
}
]
},
{
"title": "NF-kappaB RelA phosphorylation regulates RelA acetylation.",
"journal": "Molecular and cellular biology",
"date": "2005",
"authors": "Chen LF, Williams SA, Mu Y, Nakano H, Duerr JM, Buckbinder L, Greene WC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "16135789",
"url": "https://glygen.org/publication/PubMed/16135789"
}
]
},
{
"title": "The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels.",
"journal": "Experimental physiology",
"date": "2006",
"authors": "Suzuki M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "16219661",
"url": "https://glygen.org/publication/PubMed/16219661"
}
]
},
{
"title": "Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Adams DG, Coffee RL Jr, Zhang H, Pelech S, Strack S, Wadzinski BE",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16239230",
"url": "https://glygen.org/publication/PubMed/16239230"
}
]
},
{
"title": "Ras-Raf signaling needs prohibitin.",
"journal": "Cell cycle (Georgetown, Tex.)",
"date": "2005",
"authors": "Rajalingam K, Rudel T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "16294014",
"url": "https://glygen.org/publication/PubMed/16294014"
}
]
},
{
"title": "Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.",
"journal": "Molecular cell",
"date": "2005",
"authors": "Garnett MJ, Rana S, Paterson H, Barford D, Marais R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "16364920",
"url": "https://glygen.org/publication/PubMed/16364920"
}
]
},
{
"title": "Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication.",
"journal": "FEBS letters",
"date": "2006",
"authors": "Burckstummer T, Kriegs M, Lupberger J, Pauli EK, Schmittel S, Hildt E",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16405965",
"url": "https://glygen.org/publication/PubMed/16405965"
}
]
},
{
"title": "Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase.",
"journal": "Molecular biology of the cell",
"date": "2006",
"authors": "Balan V, Leicht DT, Zhu J, Balan K, Kaplun A, Singh-Gupta V, Qin J, Ruan H, Comb MJ, Tzivion G",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16407412",
"url": "https://glygen.org/publication/PubMed/16407412"
}
]
},
{
"title": "DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production.",
"journal": "Blood",
"date": "2006",
"authors": "Caparros E, Munoz P, Sierra-Filardi E, Serrano-Gomez D, Puig-Kroger A, Rodriguez-Fernandez JL, Mellado M, Sancho J, Zubiaur M, Corbi AL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "16434485",
"url": "https://glygen.org/publication/PubMed/16434485"
}
]
},
{
"title": "Regulation and role of Raf-1/B-Raf heterodimerization.",
"journal": "Mol. Cell. Biol.",
"date": "2006",
"authors": "Rushworth LK, Hindley AD, O'Neill E, Kolch W",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "16508002",
"url": "https://glygen.org/publication/PubMed/16508002"
}
]
},
{
"title": "Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2006",
"authors": "Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "16537381",
"url": "https://glygen.org/publication/PubMed/16537381"
}
]
},
{
"title": "A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.",
"journal": "Molecular cell",
"date": "2006",
"authors": "Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16630891",
"url": "https://glygen.org/publication/PubMed/16630891"
}
]
},
{
"title": "Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.",
"journal": "Oncogene",
"date": "2006",
"authors": "Brummer T, Martin P, Herzog S, Misawa Y, Daly RJ, Reth M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "16702958",
"url": "https://glygen.org/publication/PubMed/16702958"
}
]
},
{
"title": "Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A(2) inhibitor.",
"journal": "Cancer biology & therapy",
"date": "2006",
"authors": "Xie Y, Yu Z, Liu L, Guo Y, Lou L",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16760675",
"url": "https://glygen.org/publication/PubMed/16760675"
}
]
},
{
"title": "Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.",
"journal": "The Journal of biological chemistry",
"date": "2006",
"authors": "Karbowniczek M, Robertson GP, Henske EP",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "16803888",
"url": "https://glygen.org/publication/PubMed/16803888"
}
]
},
{
"title": "Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement.",
"journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research",
"date": "2006",
"authors": "Pangrazio A, Poliani PL, Megarbane A, Lefranc G, Lanino E, Di Rocco M, Rucci F, Lucchini F, Ravanini M, Facchetti F, Abinun M, Vezzoni P, Villa A, Frattini A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "16813530",
"url": "https://glygen.org/publication/PubMed/16813530"
}
]
},
{
"title": "Barttin modulates trafficking and function of ClC-K channels.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2006",
"authors": "Scholl U, Hebeisen S, Janssen AG, Muller-Newen G, Alekov A, Fahlke C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "16849430",
"url": "https://glygen.org/publication/PubMed/16849430"
}
]
},
{
"title": "Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis.",
"journal": "Molecular biology reports",
"date": "2006",
"authors": "Ye G, Chen C, Han D, Xiong X, Kong Y, Wan B, Yu L",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "16850186",
"url": "https://glygen.org/publication/PubMed/16850186"
}
]
},
{
"title": "Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance.",
"journal": "Advances in enzyme regulation",
"date": "2006",
"authors": "McCubrey JA, Steelman LS, Abrams SL, Lee JT, Chang F, Bertrand FE, Navolanic PM, Terrian DM, Franklin RA, D'Assoro AB, Salisbury JL, Mazzarino MC, Stivala F, Libra M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16854453",
"url": "https://glygen.org/publication/PubMed/16854453"
}
]
},
{
"title": "Distinct functions for ERKs?",
"journal": "Journal of biology",
"date": "2006",
"authors": "Lloyd AC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "16879721",
"url": "https://glygen.org/publication/PubMed/16879721"
}
]
},
{
"title": "Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.",
"journal": "Nature cell biology",
"date": "2006",
"authors": "von Kriegsheim A, Pitt A, Grindlay GJ, Kolch W, Dhillon AS",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
}
]
},
{
"title": "Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug.",
"journal": "Oncogene",
"date": "2007-02-22",
"authors": "Wang Z, Wade P, Mandell K J, Akyildiz A, Parkos C A, Mrsny R J, Nusrat A",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "16924233",
"url": "https://glygen.org/publication/PubMed/16924233"
}
]
},
{
"title": "In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.",
"journal": "Cancer research",
"date": "2006",
"authors": "Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA, Bastian BC, Springer C, Marais R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "17018604",
"url": "https://glygen.org/publication/PubMed/17018604"
}
]
},
{
"title": "Prostaglandin E2 downregulates TNF-alpha-induced production of matrix metalloproteinase-1 in HCS-2/8 chondrocytes by inhibiting Raf-1/MEK/ERK cascade through EP4 prostanoid receptor activation.",
"journal": "Journal of cellular biochemistry",
"date": "2007",
"authors": "Fushimi K, Nakashima S, You F, Takigawa M, Shimizu K",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17031853",
"url": "https://glygen.org/publication/PubMed/17031853"
}
]
},
{
"title": "c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells.",
"journal": "Experimental cell research",
"date": "2007",
"authors": "Rush S, Khan G, Bamisaiye A, Bidwell P, Leaver HA, Rizzo MT",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17055484",
"url": "https://glygen.org/publication/PubMed/17055484"
}
]
},
{
"title": "Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.",
"journal": "Journal of neurochemistry",
"date": "2006",
"authors": "Mei M, Su B, Harrison K, Chao M, Siedlak SL, Previll LA, Jackson L, Cai DX, Zhu X",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17064357",
"url": "https://glygen.org/publication/PubMed/17064357"
}
]
},
{
"title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.",
"journal": "Cell",
"date": "2006",
"authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
}
]
},
{
"title": "Regulation of RKIP binding to the N-region of the Raf-1 kinase.",
"journal": "FEBS letters",
"date": "2006",
"authors": "Park S, Rath O, Beach S, Xiang X, Kelly SM, Luo Z, Kolch W, Yeung KC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "17097642",
"url": "https://glygen.org/publication/PubMed/17097642"
}
]
},
{
"title": "Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.",
"journal": "Cancer research",
"date": "2006",
"authors": "King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "17145850",
"url": "https://glygen.org/publication/PubMed/17145850"
}
]
},
{
"title": "p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.",
"journal": "The Journal of cell biology",
"date": "2006",
"authors": "Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "17178906",
"url": "https://glygen.org/publication/PubMed/17178906"
}
]
},
{
"title": "Phosphatase and feedback regulation of Raf-1 signaling.",
"journal": "Cell Cycle",
"date": "2007",
"authors": "Dhillon Amardeep S, von Kriegsheim Alex, Grindlay Joan, Kolch Walter",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17218791",
"url": "https://glygen.org/publication/PubMed/17218791"
}
]
},
{
"title": "Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells.",
"journal": "American journal of physiology. Lung cellular and molecular physiology",
"date": "2007",
"authors": "Osawa Y, Yim PD, Xu D, Panettieri RA, Emala CW",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17277048",
"url": "https://glygen.org/publication/PubMed/17277048"
}
]
},
{
"title": "Patterns of somatic mutation in human cancer genomes.",
"journal": "Nature",
"date": "2007",
"authors": "Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17344846",
"url": "https://glygen.org/publication/PubMed/17344846"
}
]
},
{
"title": "Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface.",
"journal": "The Biochemical journal",
"date": "2007",
"authors": "Wiemuth D, Ke Y, Rohlfs M, McDonald FJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "17381423",
"url": "https://glygen.org/publication/PubMed/17381423"
}
]
},
{
"title": "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress.",
"journal": "Journal of virology",
"date": "2007",
"authors": "Chen J, Siddiqui A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17428866",
"url": "https://glygen.org/publication/PubMed/17428866"
}
]
},
{
"title": "The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm.",
"journal": "Cell",
"date": "2007",
"authors": "Lu B, Su Y, Das S, Liu J, Xia J, Ren D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "17448995",
"url": "https://glygen.org/publication/PubMed/17448995"
}
]
},
{
"title": "C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.",
"journal": "Immunity",
"date": "2007",
"authors": "Gringhuis SI, den Dunnen J, Litjens M, van Het Hof B, van Kooyk Y, Geijtenbeek TB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "17462920",
"url": "https://glygen.org/publication/PubMed/17462920"
}
]
},
{
"title": "Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation.",
"journal": "Journal of cellular biochemistry",
"date": "2007",
"authors": "Belot MP, Abdennebi-Najar L, Gaudin F, Emilie D, Machelon V",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17492661",
"url": "https://glygen.org/publication/PubMed/17492661"
}
]
},
{
"title": "KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.",
"journal": "Oncogene",
"date": "2007",
"authors": "Claperon A, Therrien M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "17496912",
"url": "https://glygen.org/publication/PubMed/17496912"
}
]
},
{
"title": "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.",
"journal": "Science (New York, N.Y.)",
"date": "2007",
"authors": "Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "17525332",
"url": "https://glygen.org/publication/PubMed/17525332"
}
]
},
{
"title": "IQGAP1 modulates activation of B-Raf.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2007",
"authors": "Ren JG, Li Z, Sacks DB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "17563371",
"url": "https://glygen.org/publication/PubMed/17563371"
}
]
},
{
"title": "Germline gain-of-function mutations in RAF1 cause Noonan syndrome.",
"journal": "Nature genetics",
"date": "2007",
"authors": "Razzaque MA, Nishizawa T, Komoike Y, Yagi H, Furutani M, Amo R, Kamisago M, Momma K, Katayama H, Nakagawa M, Fujiwara Y, Matsushima M, Mizuno K, Tokuyama M, Hirota H, Muneuchi J, Higashinakagawa T, Matsuoka R",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "17603482",
"url": "https://glygen.org/publication/PubMed/17603482"
}
]
},
{
"title": "Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.",
"journal": "Nature genetics",
"date": "2007",
"authors": "Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Landstrom A, Bos JM, Ommen SR, Esposito G, Lepri F, Faul C, Mundel P, Lopez Siguero JP, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Torrente I, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "17603483",
"url": "https://glygen.org/publication/PubMed/17603483"
}
]
},
{
"title": "Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor.",
"journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
"date": "2008",
"authors": "Franceschini S, Ilari A, Verzili D, Zamparelli C, Antaramian A, Rueda A, Valdivia HH, Chiancone E, Colotti G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "17699613",
"url": "https://glygen.org/publication/PubMed/17699613"
}
]
},
{
"title": "Spatial regulation of Raf kinase signaling by RKTG.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2007",
"authors": "Feng L, Xie X, Ding Q, Luo X, He J, Fan F, Liu W, Wang Z, Chen Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "17724343",
"url": "https://glygen.org/publication/PubMed/17724343"
}
]
},
{
"title": "Zinc-dependent suppression of TNF-alpha production is mediated by protein kinase A-induced inhibition of Raf-1, I kappa B kinase beta, and NF-kappa B.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "2007",
"authors": "von Bulow V, Dubben S, Engelhardt G, Hebel S, Plumakers B, Heine H, Rink L, Haase H",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "17785857",
"url": "https://glygen.org/publication/PubMed/17785857"
}
]
},
{
"title": "Characterization of human cardiac calsequestrin and its deleterious mutants.",
"journal": "Journal of molecular biology",
"date": "2007",
"authors": "Kim E, Youn B, Kemper L, Campbell C, Milting H, Varsanyi M, Kang C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "17881003",
"url": "https://glygen.org/publication/PubMed/17881003"
}
]
},
{
"title": "A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2007",
"authors": "Xiang M, Feng M, Muend S, Rao R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18000046",
"url": "https://glygen.org/publication/PubMed/18000046"
}
]
},
{
"title": "Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets.",
"journal": "The Journal of biological chemistry",
"date": "2008",
"authors": "Hoffmeister M, Riha P, Neumuller O, Danielewski O, Schultess J, Smolenski AP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "18039662",
"url": "https://glygen.org/publication/PubMed/18039662"
}
]
},
{
"title": "Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers.",
"journal": "Journal of molecular endocrinology",
"date": "2007",
"authors": "Nakamura M, Han B, Nishishita T, Bai Y, Kakudo K",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18055485",
"url": "https://glygen.org/publication/PubMed/18055485"
}
]
},
{
"title": "Determinants of anion-proton coupling in mammalian endosomal CLC proteins.",
"journal": "The Journal of biological chemistry",
"date": "2008",
"authors": "Zdebik AA, Zifarelli G, Bergsdorf EY, Soliani P, Scheel O, Jentsch TJ, Pusch M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18063579",
"url": "https://glygen.org/publication/PubMed/18063579"
}
]
},
{
"title": "GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.",
"journal": "Journal of cellular physiology",
"date": "2008",
"authors": "Shu CW, Sun FC, Cho JH, Lin CC, Liu PF, Chen PY, Chang MD, Fu HW, Lai YK",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18064632",
"url": "https://glygen.org/publication/PubMed/18064632"
}
]
},
{
"title": "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.",
"journal": "J. Proteome Res.",
"date": "2008",
"authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd",
"evidence": [
{
"database": "UniProtKB",
"id": "H7C155",
"url": "https://www.uniprot.org/uniprot/H7C155"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18220336",
"url": "https://glygen.org/publication/PubMed/18220336"
}
]
},
{
"title": "Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2008",
"authors": "Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim SH, Schlessinger J, Zhang KY, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "18287029",
"url": "https://glygen.org/publication/PubMed/18287029"
}
]
},
{
"title": "The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.",
"journal": "Cell. Signal.",
"date": "2008",
"authors": "Rath O, Park S, Tang HH, Banfield MJ, Brady RL, Lee YC, Dignam JD, Sedivy JM, Kolch W, Yeung KC",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "18294816",
"url": "https://glygen.org/publication/PubMed/18294816"
}
]
},
{
"title": "Molecular analysis of digenic inheritance in Bartter syndrome with sensorineural deafness.",
"journal": "Journal of medical genetics",
"date": "2008",
"authors": "Nozu K, Inagaki T, Fu XJ, Nozu Y, Kaito H, Kanda K, Sekine T, Igarashi T, Nakanishi K, Yoshikawa N, Iijima K, Matsuo M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18310267",
"url": "https://glygen.org/publication/PubMed/18310267"
}
]
},
{
"title": "IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds.",
"journal": "The Journal of biological chemistry",
"date": "2008",
"authors": "Chen C, Lewis RE, White MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "18332145",
"url": "https://glygen.org/publication/PubMed/18332145"
}
]
},
{
"title": "Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases.",
"journal": "Cellular signalling",
"date": "2008",
"authors": "Pan MR, Chang HC, Hung WC",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18374541",
"url": "https://glygen.org/publication/PubMed/18374541"
}
]
},
{
"title": "Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype.",
"journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
"date": "2008",
"authors": "Yoon C, Korade Z, Carter BD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "18385332",
"url": "https://glygen.org/publication/PubMed/18385332"
}
]
},
{
"title": "Bestrophin Cl- channels are highly permeable to HCO3-.",
"journal": "American journal of physiology. Cell physiology",
"date": "2008",
"authors": "Qu Z, Hartzell HC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18400985",
"url": "https://glygen.org/publication/PubMed/18400985"
}
]
},
{
"title": "The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes.",
"journal": "Nature",
"date": "2008",
"authors": "Graves AR, Curran PK, Smith CL, Mindell JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18449189",
"url": "https://glygen.org/publication/PubMed/18449189"
}
]
},
{
"title": "Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1991",
"authors": "Polakis PG, Rubinfeld B, Evans T, McCormick F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "1846040",
"url": "https://glygen.org/publication/PubMed/1846040"
}
]
},
{
"title": "p21 activated kinase 5 activates Raf-1 and targets it to mitochondria.",
"journal": "Journal of cellular biochemistry",
"date": "2008",
"authors": "Wu X, Carr HS, Dan I, Ruvolo PP, Frost JA",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18465753",
"url": "https://glygen.org/publication/PubMed/18465753"
}
]
},
{
"title": "Characterization of the sodium/hydrogen exchanger NHA2.",
"journal": "Journal of the American Society of Nephrology : JASN",
"date": "2008",
"authors": "Fuster DG, Zhang J, Shi M, Bobulescu IA, Andersson S, Moe OW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18508966",
"url": "https://glygen.org/publication/PubMed/18508966"
}
]
},
{
"title": "RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.",
"journal": "Carcinogenesis",
"date": "2008",
"authors": "Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, Wang Z, Chen Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "18515281",
"url": "https://glygen.org/publication/PubMed/18515281"
}
]
},
{
"title": "Characterization of the topology and functional domains of RKTG.",
"journal": "The Biochemical journal",
"date": "2008",
"authors": "Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "18547165",
"url": "https://glygen.org/publication/PubMed/18547165"
}
]
},
{
"title": "Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.",
"journal": "Cancer research",
"date": "2008",
"authors": "Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "18559533",
"url": "https://glygen.org/publication/PubMed/18559533"
}
]
},
{
"title": "The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells.",
"journal": "The international journal of biochemistry & cell biology",
"date": "2008",
"authors": "Ramos JW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "18562239",
"url": "https://glygen.org/publication/PubMed/18562239"
}
]
},
{
"title": "Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.",
"journal": "The European journal of neuroscience",
"date": "2008",
"authors": "Donier E, Rugiero F, Jacob C, Wood JN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18662336",
"url": "https://glygen.org/publication/PubMed/18662336"
}
]
},
{
"title": "Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.",
"journal": "The Journal of biological chemistry",
"date": "2008",
"authors": "Baljuls A, Schmitz W, Mueller T, Zahedi RP, Sickmann A, Hekman M, Rapp UR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "18662992",
"url": "https://glygen.org/publication/PubMed/18662992"
}
]
},
{
"title": "A quantitative atlas of mitotic phosphorylation.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2008",
"authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
}
]
},
{
"title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.",
"journal": "Mol. Cell",
"date": "2008",
"authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M",
"evidence": [
{
"database": "UniProtKB",
"id": "A0A0B4J1W9",
"url": "https://www.uniprot.org/uniprot/A0A0B4J1W9"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
]
},
{
"title": "TMEM16A confers receptor-activated calcium-dependent chloride conductance.",
"journal": "Nature",
"date": "2008",
"authors": "Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "18724360",
"url": "https://glygen.org/publication/PubMed/18724360"
}
]
},
{
"title": "Successive and selective release of phosphorylated peptides captured by hydroxy acid-modified metal oxide chromatography.",
"journal": "Journal of proteome research",
"date": "2008",
"authors": "Kyono Y, Sugiyama N, Imami K, Tomita M, Ishihama Y",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "18767875",
"url": "https://glygen.org/publication/PubMed/18767875"
}
]
},
{
"title": "Characterization of Ser338 phosphorylation for Raf-1 activation.",
"journal": "The Journal of biological chemistry",
"date": "2008",
"authors": "Zang M, Gong J, Luo L, Zhou J, Xiang X, Huang W, Huang Q, Luo X, Olbrot M, Peng Y, Chen C, Luo Z",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18775988",
"url": "https://glygen.org/publication/PubMed/18775988"
}
]
},
{
"title": "Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis.",
"journal": "Arthritis and rheumatism",
"date": "2008",
"authors": "Lin SK, Chang HH, Chen YJ, Wang CC, Galson DL, Hong CY, Kok SH",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "18821707",
"url": "https://glygen.org/publication/PubMed/18821707"
}
]
},
{
"title": "An alternatively spliced c-mil/raf mRNA is predominantly expressed in chicken muscular tissues and conserved among vertebrate species.",
"journal": "Oncogene",
"date": "1991",
"authors": "Dozier C, Ansieau S, Ferreira E, Coll J, Stehelin D",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "1886707",
"url": "https://glygen.org/publication/PubMed/1886707"
}
]
},
{
"title": "Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.",
"journal": "Cancer research",
"date": "2008",
"authors": "Jones DT, Kocialkowski S, Liu L, Pearson DM, Backlund LM, Ichimura K, Collins VP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "18974108",
"url": "https://glygen.org/publication/PubMed/18974108"
}
]
},
{
"title": "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.",
"journal": "Analytical chemistry",
"date": "2008",
"authors": "Wang B, Malik R, Nigg EA, Korner R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "19007248",
"url": "https://glygen.org/publication/PubMed/19007248"
}
]
},
{
"title": "Regulation of RAF activity by 14-3-3 proteins: RAF kinases associate functionally with both homo- and heterodimeric forms of 14-3-3 proteins.",
"journal": "The Journal of biological chemistry",
"date": "2009",
"authors": "Fischer A, Baljuls A, Reinders J, Nekhoroshkova E, Sibilski C, Metz R, Albert S, Rajalingam K, Hekman M, Rapp UR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "19049963",
"url": "https://glygen.org/publication/PubMed/19049963"
}
]
},
{
"title": "Protein scaffolds in MAP kinase signalling.",
"journal": "Cellular signalling",
"date": "2009",
"authors": "Brown MD, Sacks DB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "19091303",
"url": "https://glygen.org/publication/PubMed/19091303"
}
]
},
{
"title": "Signaling threshold regulation by the Ras effector IMP.",
"journal": "The Journal of biological chemistry",
"date": "2009",
"authors": "Matheny SA, White MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "19091743",
"url": "https://glygen.org/publication/PubMed/19091743"
}
]
},
{
"title": "Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.",
"journal": "Nature immunology",
"date": "2009",
"authors": "Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "19122653",
"url": "https://glygen.org/publication/PubMed/19122653"
}
]
},
{
"title": "Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.",
"journal": "Toxicology and applied pharmacology",
"date": "2009",
"authors": "Wang CY, Wang YT, Tzeng DW, Yang JL",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19133285",
"url": "https://glygen.org/publication/PubMed/19133285"
}
]
},
{
"title": "Voltage-dependent and -independent titration of specific residues accounts for complex gating of a ClC chloride channel by extracellular protons.",
"journal": "The Journal of physiology",
"date": "2009",
"authors": "Niemeyer MI, Cid LP, Yusef YR, Briones R, Sepulveda FV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19153159",
"url": "https://glygen.org/publication/PubMed/19153159"
}
]
},
{
"title": "Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway.",
"journal": "Journal of cell science",
"date": "2009",
"authors": "Shin SY, Rath O, Choo SM, Fee F, McFerran B, Kolch W, Cho KH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "19158341",
"url": "https://glygen.org/publication/PubMed/19158341"
}
]
},
{
"title": "Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.",
"journal": "PloS one",
"date": "2009",
"authors": "Reber L, Vermeulen L, Haegeman G, Frossard N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "19197368",
"url": "https://glygen.org/publication/PubMed/19197368"
}
]
},
{
"title": "A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.",
"journal": "Nature structural & molecular biology",
"date": "2009",
"authors": "Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O, Baccarini M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "19219045",
"url": "https://glygen.org/publication/PubMed/19219045"
}
]
},
{
"title": "Total ERK1/2 activity regulates cell proliferation.",
"journal": "Cell cycle (Georgetown, Tex.)",
"date": "2009",
"authors": "Lefloch R, Pouyssegur J, Lenormand P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "19242111",
"url": "https://glygen.org/publication/PubMed/19242111"
}
]
},
{
"title": "ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.",
"journal": "Cell cycle (Georgetown, Tex.)",
"date": "2009",
"authors": "Casar B, Pinto A, Crespo P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "19279408",
"url": "https://glygen.org/publication/PubMed/19279408"
}
]
},
{
"title": "Ultrasound stimulates NF-kappaB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts.",
"journal": "Journal of cellular physiology",
"date": "2009",
"authors": "Hou CH, Lin J, Huang SC, Hou SM, Tang CH",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19288477",
"url": "https://glygen.org/publication/PubMed/19288477"
}
]
},
{
"title": "Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells.",
"journal": "Exp. Cell Res.",
"date": "2009",
"authors": "Smith J, Bunaciu RP, Reiterer G, Coder D, George T, Asaly M, Yen A",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19298812",
"url": "https://glygen.org/publication/PubMed/19298812"
}
]
},
{
"title": "Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents.",
"journal": "The Journal of physiology",
"date": "2009",
"authors": "Hamann M, Gibson A, Davies N, Jowett A, Walhin JP, Partington L, Affleck K, Trezise D, Main M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19307298",
"url": "https://glygen.org/publication/PubMed/19307298"
}
]
},
{
"title": "Epithelial sodium channel regulated by differential composition of a signaling complex.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2009",
"authors": "Soundararajan R, Melters D, Shih IC, Wang J, Pearce D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19380724",
"url": "https://glygen.org/publication/PubMed/19380724"
}
]
},
{
"title": "NAADP mobilizes calcium from acidic organelles through two-pore channels.",
"journal": "Nature",
"date": "2009",
"authors": "Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19387438",
"url": "https://glygen.org/publication/PubMed/19387438"
}
]
},
{
"title": "von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.",
"journal": "The Journal of clinical investigation",
"date": "1991",
"authors": "Kroll MH, Harris TS, Moake JL, Handin RI, Schafer AI",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "1939645",
"url": "https://glygen.org/publication/PubMed/1939645"
}
]
},
{
"title": "The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation.",
"journal": "Current opinion in genetics & development",
"date": "2009",
"authors": "Tidyman WE, Rauen KA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "19467855",
"url": "https://glygen.org/publication/PubMed/19467855"
}
]
},
{
"title": "Signaling dynamics of the KSR1 scaffold complex.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2009",
"authors": "McKay MM, Ritt DA, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "19541618",
"url": "https://glygen.org/publication/PubMed/19541618"
}
]
},
{
"title": "The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch.",
"journal": "Cellular signalling",
"date": "2009",
"authors": "Dhillon AS, Yip YY, Grindlay GJ, Pakay JL, Dangers M, Hillmann M, Clark W, Pitt A, Mischak H, Kolch W",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19595761",
"url": "https://glygen.org/publication/PubMed/19595761"
}
]
},
{
"title": "Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.",
"journal": "The Journal of cell biology",
"date": "2009",
"authors": "Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19620632",
"url": "https://glygen.org/publication/PubMed/19620632"
}
]
},
{
"title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.",
"journal": "Molecular & cellular proteomics : MCP",
"date": "2009",
"authors": "Pan C, Olsen JV, Daub H, Mann M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
}
]
},
{
"title": "Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.",
"journal": "Nature genetics",
"date": "2009",
"authors": "Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "19684605",
"url": "https://glygen.org/publication/PubMed/19684605"
}
]
},
{
"title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.",
"journal": "Science signaling",
"date": "2009",
"authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19690332",
"url": "https://glygen.org/publication/PubMed/19690332"
}
]
},
{
"title": "Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.",
"journal": "J. Biol. Chem.",
"date": "2009",
"authors": "Yasuda S, Kai M, Imai S, Takeishi K, Taketomi A, Toyota M, Kanoh H, Sakane F",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19710016",
"url": "https://glygen.org/publication/PubMed/19710016"
}
]
},
{
"title": "Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells.",
"journal": "Pharmacological research",
"date": "2009",
"authors": "Chang MS, Chen BC, Weng CM, Lee WS, Lin CH",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19717011",
"url": "https://glygen.org/publication/PubMed/19717011"
}
]
},
{
"title": "A dimerization-dependent mechanism drives RAF catalytic activation.",
"journal": "Nature",
"date": "2009",
"authors": "Rajakulendran T, Sahmi M, Lefrancois M, Sicheri F, Therrien M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "19727074",
"url": "https://glygen.org/publication/PubMed/19727074"
}
]
},
{
"title": "Kinase suppressor of Ras transphosphorylates c-Raf-1.",
"journal": "Biochemical and biophysical research communications",
"date": "2009",
"authors": "Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "19766101",
"url": "https://glygen.org/publication/PubMed/19766101"
}
]
},
{
"title": "Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels.",
"journal": "Molecular pharmacology",
"date": "2010",
"authors": "Tradtrantip L, Namkung W, Verkman AS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19808995",
"url": "https://glygen.org/publication/PubMed/19808995"
}
]
},
{
"title": "Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.",
"journal": "Molecular and cellular biology",
"date": "2010",
"authors": "Ritt DA, Monson DM, Specht SI, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "19933846",
"url": "https://glygen.org/publication/PubMed/19933846"
}
]
},
{
"title": "Molecular and clinical heterogeneity in CLCN7-dependent osteopetrosis: report of 20 novel mutations.",
"journal": "Human mutation",
"date": "2010",
"authors": "Pangrazio A, Pusch M, Caldana E, Frattini A, Lanino E, Tamhankar PM, Phadke S, Lopez AG, Orchard P, Mihci E, Abinun M, Wright M, Vettenranta K, Bariae I, Melis D, Tezcan I, Baumann C, Locatelli F, Zecca M, Horwitz E, Mansour LS, Van Roij M, Vezzoni P, Villa A, Sobacchi C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "19953639",
"url": "https://glygen.org/publication/PubMed/19953639"
}
]
},
{
"title": "Prostaglandin E2 activates cAMP response element-binding protein in glioma cells via a signaling pathway involving PKA-dependent inhibition of ERK.",
"journal": "Prostaglandins & other lipid mediators",
"date": "2010",
"authors": "Bidwell P, Joh K, Leaver HA, Rizzo MT",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20015475",
"url": "https://glygen.org/publication/PubMed/20015475"
}
]
},
{
"title": "Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.",
"journal": "Human mutation",
"date": "2010",
"authors": "Kobayashi T, Aoki Y, Niihori T, Cave H, Verloes A, Okamoto N, Kawame H, Fujiwara I, Takada F, Ohata T, Sakazume S, Ando T, Nakagawa N, Lapunzina P, Meneses AG, Gillessen-Kaesbach G, Wieczorek D, Kurosawa K, Mizuno S, Ohashi H, David A, Philip N, Guliyeva A, Narumi Y, Kure S, Tsuchiya S, Matsubara Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20052757",
"url": "https://glygen.org/publication/PubMed/20052757"
}
]
},
{
"title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.",
"journal": "Science signaling",
"date": "2010",
"authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
]
},
{
"title": "The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress.",
"journal": "The Journal of clinical investigation",
"date": "1991",
"authors": "Ikeda Y, Handa M, Kawano K, Kamata T, Murata M, Araki Y, Anbo H, Kawai Y, Watanabe K, Itagaki I, et al.",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "2010539",
"url": "https://glygen.org/publication/PubMed/2010539"
}
]
},
{
"title": "RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.",
"journal": "Nature",
"date": "2010",
"authors": "Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "20130576",
"url": "https://glygen.org/publication/PubMed/20130576"
}
]
},
{
"title": "Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.",
"journal": "Cell",
"date": "2010",
"authors": "Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis-Filho JS, Springer CJ, Pritchard C, Marais R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20141835",
"url": "https://glygen.org/publication/PubMed/20141835"
}
]
},
{
"title": "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.",
"journal": "Pigment cell & melanoma research",
"date": "2010",
"authors": "Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20149136",
"url": "https://glygen.org/publication/PubMed/20149136"
}
]
},
{
"title": "A homogenous luminescent proximity assay for 14-3-3 interactions with both phosphorylated and nonphosphorylated client peptides.",
"journal": "Current chemical genomics",
"date": "2008",
"authors": "Du Y, Khuri FR, Fu H",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20161842",
"url": "https://glygen.org/publication/PubMed/20161842"
}
]
},
{
"title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.",
"journal": "Electrophoresis",
"date": "2010",
"authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "20166139",
"url": "https://glygen.org/publication/PubMed/20166139"
}
]
},
{
"title": "RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.",
"journal": "Nature",
"date": "2010",
"authors": "Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "20179705",
"url": "https://glygen.org/publication/PubMed/20179705"
}
]
},
{
"title": "Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation.",
"journal": "The Journal of biological chemistry",
"date": "2010",
"authors": "Kilili GK, Kyriakis JM",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20212043",
"url": "https://glygen.org/publication/PubMed/20212043"
}
]
},
{
"title": "Phosphoproteomic analysis of primary human multiple myeloma cells.",
"journal": "Journal of proteomics",
"date": "2010",
"authors": "Ge F, Xiao CL, Yin XF, Lu CH, Zeng HL, He QY",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "20230923",
"url": "https://glygen.org/publication/PubMed/20230923"
}
]
},
{
"title": "PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.",
"journal": "Cancer research",
"date": "2010",
"authors": "Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "20332238",
"url": "https://glygen.org/publication/PubMed/20332238"
}
]
},
{
"title": "C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity.",
"journal": "Cellular signalling",
"date": "2010",
"authors": "Svajger U, Anderluh M, Jeras M, Obermajer N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "20363321",
"url": "https://glygen.org/publication/PubMed/20363321"
}
]
},
{
"title": "Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.",
"journal": "Cardiovascular research",
"date": "2010",
"authors": "Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "20388639",
"url": "https://glygen.org/publication/PubMed/20388639"
}
]
},
{
"title": "The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression.",
"journal": "The Journal of biological chemistry",
"date": "2010",
"authors": "Neagoe I, Stauber T, Fidzinski P, Bergsdorf EY, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "20466723",
"url": "https://glygen.org/publication/PubMed/20466723"
}
]
},
{
"title": "Mechanical signals control SOX-9, VEGF, and c-Myc expression and cell proliferation during inflammation via integrin-linked kinase, B-Raf, and ERK1/2-dependent signaling in articular chondrocytes.",
"journal": "Arthritis research & therapy",
"date": "2010",
"authors": "Perera PM, Wypasek E, Madhavan S, Rath-Deschner B, Liu J, Nam J, Rath B, Huang Y, Deschner J, Piesco N, Wu C, Agarwal S",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20509944",
"url": "https://glygen.org/publication/PubMed/20509944"
}
]
},
{
"title": "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.",
"journal": "The Journal of biological chemistry",
"date": "2010",
"authors": "Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "20525693",
"url": "https://glygen.org/publication/PubMed/20525693"
}
]
},
{
"title": "Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.",
"journal": "Nature medicine",
"date": "2010",
"authors": "Palanisamy N, Ateeq B, Kalyana-Sundaram S, Pflueger D, Ramnarayanan K, Shankar S, Han B, Cao Q, Cao X, Suleman K, Kumar-Sinha C, Dhanasekaran SM, Chen YB, Esgueva R, Banerjee S, LaFargue CJ, Siddiqui J, Demichelis F, Moeller P, Bismar TA, Kuefer R, Fullen DR, Johnson TM, Greenson JK, Giordano TJ, Tan P, Tomlins SA, Varambally S, Rubin MA, Maher CA, Chinnaiyan AM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "20526349",
"url": "https://glygen.org/publication/PubMed/20526349"
}
]
},
{
"title": "Barttin activates ClC-K channel function by modulating gating.",
"journal": "Journal of the American Society of Nephrology : JASN",
"date": "2010",
"authors": "Fischer M, Janssen AG, Fahlke C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "20538786",
"url": "https://glygen.org/publication/PubMed/20538786"
}
]
},
{
"title": "RAF protein-serine/threonine kinases: structure and regulation.",
"journal": "Biochem. Biophys. Res. Commun.",
"date": "2010",
"authors": "Roskoski R Jr",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "20674547",
"url": "https://glygen.org/publication/PubMed/20674547"
}
]
},
{
"title": "Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations.",
"journal": "American journal of medical genetics. Part A",
"date": "2010",
"authors": "Longoni M, Moncini S, Cisternino M, Morella IM, Ferraiuolo S, Russo S, Mannarino S, Brazzelli V, Coi P, Zippel R, Venturin M, Riva P",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20683980",
"url": "https://glygen.org/publication/PubMed/20683980"
}
]
},
{
"title": "Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.",
"journal": "The Journal of biological chemistry",
"date": "2010",
"authors": "Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, Heumann R, Stoll R",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20685651",
"url": "https://glygen.org/publication/PubMed/20685651"
}
]
},
{
"title": "Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.",
"journal": "Cellular signalling",
"date": "2011",
"authors": "Yang W, Ju JH, Lee KM, Shin I",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20688159",
"url": "https://glygen.org/publication/PubMed/20688159"
}
]
},
{
"title": "Inhibition of mutated, activated BRAF in metastatic melanoma.",
"journal": "The New England journal of medicine",
"date": "2010",
"authors": "Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "20818844",
"url": "https://glygen.org/publication/PubMed/20818844"
}
]
},
{
"title": "Mechanistic principles of RAF kinase signaling.",
"journal": "Cellular and molecular life sciences : CMLS",
"date": "2011",
"authors": "Udell CM, Rajakulendran T, Sicheri F, Therrien M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "20820846",
"url": "https://glygen.org/publication/PubMed/20820846"
}
]
},
{
"title": "Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.",
"journal": "Science signaling",
"date": "2010",
"authors": "Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, Bastiaens PI",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "20858867",
"url": "https://glygen.org/publication/PubMed/20858867"
}
]
},
{
"title": "Regulation of Erk1/2 activation by osteopontin in PC3 human prostate cancer cells.",
"journal": "Molecular cancer",
"date": "2010",
"authors": "Robertson BW, Bonsal L, Chellaiah MA",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20868520",
"url": "https://glygen.org/publication/PubMed/20868520"
}
]
},
{
"title": "Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42.",
"journal": "Biochimica et biophysica acta",
"date": "2011",
"authors": "Zhang B, Li S, Harbrecht BG",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20934465",
"url": "https://glygen.org/publication/PubMed/20934465"
}
]
},
{
"title": "Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.",
"journal": "Molecular and cellular biology",
"date": "2011",
"authors": "Moniz LS, Stambolic V",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "20956560",
"url": "https://glygen.org/publication/PubMed/20956560"
}
]
},
{
"title": "Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.",
"journal": "Neuron",
"date": "2010",
"authors": "Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "21040849",
"url": "https://glygen.org/publication/PubMed/21040849"
}
]
},
{
"title": "Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.",
"journal": "Nature",
"date": "2010",
"authors": "Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "21107323",
"url": "https://glygen.org/publication/PubMed/21107323"
}
]
},
{
"title": "Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.",
"journal": "Acta neuropathologica",
"date": "2011",
"authors": "Cin H, Meyer C, Herr R, Janzarik WG, Lambert S, Jones DT, Jacob K, Benner A, Witt H, Remke M, Bender S, Falkenstein F, Van Anh TN, Olbrich H, von Deimling A, Pekrun A, Kulozik AE, Gnekow A, Scheurlen W, Witt O, Omran H, Jabado N, Collins VP, Brummer T, Marschalek R, Lichter P, Korshunov A, Pfister SM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "21424530",
"url": "https://glygen.org/publication/PubMed/21424530"
}
]
},
{
"title": "Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2011",
"authors": "Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "21441104",
"url": "https://glygen.org/publication/PubMed/21441104"
}
]
},
{
"title": "A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.",
"journal": "Nature",
"date": "2011",
"authors": "Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "21441910",
"url": "https://glygen.org/publication/PubMed/21441910"
}
]
},
{
"title": "c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.",
"journal": "Cancer cell",
"date": "2011",
"authors": "Blasco RB, Francoz S, Santamaria D, Canamero M, Dubus P, Charron J, Baccarini M, Barbacid M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "21514245",
"url": "https://glygen.org/publication/PubMed/21514245"
}
]
},
{
"title": "ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity.",
"journal": "The EMBO journal",
"date": "2011",
"authors": "Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "21527911",
"url": "https://glygen.org/publication/PubMed/21527911"
}
]
},
{
"title": "Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway.",
"journal": "Biochemical and biophysical research communications",
"date": "2011",
"authors": "D'Ambrosio SM, Han C, Pan L, Kinghorn AD, Ding H",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "21596018",
"url": "https://glygen.org/publication/PubMed/21596018"
}
]
},
{
"title": "Improved survival with vemurafenib in melanoma with BRAF V600E mutation.",
"journal": "The New England journal of medicine",
"date": "2011",
"authors": "Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "21639808",
"url": "https://glygen.org/publication/PubMed/21639808"
}
]
},
{
"title": "c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.",
"journal": "Cancer biology & therapy",
"date": "2011",
"authors": "Carr BI, Wang Z, Wang M, Cavallini A, D'Alessandro R, Refolo MG",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "21734462",
"url": "https://glygen.org/publication/PubMed/21734462"
}
]
},
{
"title": "Raf family kinases: old dogs have learned new tricks.",
"journal": "Genes Cancer",
"date": "2011",
"authors": "Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "21779496",
"url": "https://glygen.org/publication/PubMed/21779496"
}
]
},
{
"title": "Spectrum of mutations in Noonan syndrome and their correlation with phenotypes.",
"journal": "The Journal of pediatrics",
"date": "2011",
"authors": "Lee BH, Kim JM, Jin HY, Kim GH, Choi JH, Yoo HW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "21784453",
"url": "https://glygen.org/publication/PubMed/21784453"
}
]
},
{
"title": "Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.",
"journal": "Science signaling",
"date": "2011",
"authors": "Andreu-Perez P, Esteve-Puig R, de Torre-Minguela C, Lopez-Fauqued M, Bech-Serra JJ, Tenbaum S, Garcia-Trevijano ER, Canals F, Merlino G, Avila MA, Recio JA",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
}
]
},
{
"title": "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.",
"journal": "Experimental physiology",
"date": "2012",
"authors": "Scudieri P, Sondo E, Ferrera L, Galietta LJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "21984732",
"url": "https://glygen.org/publication/PubMed/21984732"
}
]
},
{
"title": "RAS oncogenes: weaving a tumorigenic web.",
"journal": "Nature reviews. Cancer",
"date": "2011",
"authors": "Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "21993244",
"url": "https://glygen.org/publication/PubMed/21993244"
}
]
},
{
"title": "C-Raf is required for the initiation of lung cancer by K-Ras(G12D).",
"journal": "Cancer discovery",
"date": "2011",
"authors": "Karreth FA, Frese KK, DeNicola GM, Baccarini M, Tuveson DA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22043453",
"url": "https://glygen.org/publication/PubMed/22043453"
}
]
},
{
"title": "p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112.",
"journal": "PloS one",
"date": "2011",
"authors": "Ye DZ, Jin S, Zhuo Y, Field J",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22096607",
"url": "https://glygen.org/publication/PubMed/22096607"
}
]
},
{
"title": "RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).",
"journal": "Nature",
"date": "2011",
"authors": "Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22113612",
"url": "https://glygen.org/publication/PubMed/22113612"
}
]
},
{
"title": "Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells.",
"journal": "Oncogene",
"date": "2012",
"authors": "Khanal P, Yun HJ, Lim SC, Ahn SG, Yoon HE, Kang KW, Hong R, Choi HS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22158035",
"url": "https://glygen.org/publication/PubMed/22158035"
}
]
},
{
"title": "MEK1/2 dual-specificity protein kinases: structure and regulation.",
"journal": "Biochemical and biophysical research communications",
"date": "2012",
"authors": "Roskoski R Jr",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "22177953",
"url": "https://glygen.org/publication/PubMed/22177953"
}
]
},
{
"title": "Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells.",
"journal": "Leukemia",
"date": "2012",
"authors": "Congleton J, MacDonald R, Yen A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22182854",
"url": "https://glygen.org/publication/PubMed/22182854"
}
]
},
{
"title": "Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma.",
"journal": "Small GTPases",
"date": "2011",
"authors": "Dumaz N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22292133",
"url": "https://glygen.org/publication/PubMed/22292133"
}
]
},
{
"title": "Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.",
"journal": "The New England journal of medicine",
"date": "2012",
"authors": "Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Hersey P, Kefford R, Lawrence D, Puzanov I, Lewis KD, Amaravadi RK, Chmielowski B, Lawrence HJ, Shyr Y, Ye F, Li J, Nolop KB, Lee RJ, Joe AK, Ribas A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22356324",
"url": "https://glygen.org/publication/PubMed/22356324"
}
]
},
{
"title": "Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance.",
"journal": "Nature communications",
"date": "2012",
"authors": "Shi H, Moriceau G, Kong X, Lee MK, Lee H, Koya RC, Ng C, Chodon T, Scolyer RA, Dahlman KB, Sosman JA, Kefford RF, Long GV, Nelson SF, Ribas A, Lo RS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22395615",
"url": "https://glygen.org/publication/PubMed/22395615"
}
]
},
{
"title": "Hybrid cells derived from breast epithelial cell/breast cancer cell fusion events show a differential RAF-AKT crosstalk.",
"journal": "Cell communication and signaling : CCS",
"date": "2012",
"authors": "Ozel C, Seidel J, Meyer-Staeckling S, Brandt BH, Niggemann B, Zanker KS, Dittmar T",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22487193",
"url": "https://glygen.org/publication/PubMed/22487193"
}
]
},
{
"title": "Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.",
"journal": "The EMBO journal",
"date": "2012",
"authors": "Roring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22510884",
"url": "https://glygen.org/publication/PubMed/22510884"
}
]
},
{
"title": "Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "2012",
"authors": "Thangavelu K, Pan CQ, Karlberg T, Balaji G, Uttamchandani M, Suresh V, Schuler H, Low BC, Sivaraman J",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22538822",
"url": "https://glygen.org/publication/PubMed/22538822"
}
]
},
{
"title": "ERK1/2 MAP kinases: structure, function, and regulation.",
"journal": "Pharmacological research",
"date": "2012",
"authors": "Roskoski R Jr",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "22569528",
"url": "https://glygen.org/publication/PubMed/22569528"
}
]
},
{
"title": "A comprehensive survey of Ras mutations in cancer.",
"journal": "Cancer research",
"date": "2012",
"authors": "Prior IA, Lewis PD, Mattos C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "22589270",
"url": "https://glygen.org/publication/PubMed/22589270"
}
]
},
{
"title": "Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation.",
"journal": "Cell cycle (Georgetown, Tex.)",
"date": "2012",
"authors": "Salzano M, Rusciano MR, Russo E, Bifulco M, Postiglione L, Vitale M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22592532",
"url": "https://glygen.org/publication/PubMed/22592532"
}
]
},
{
"title": "p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response.",
"journal": "The Journal of biological chemistry",
"date": "2012",
"authors": "Hou S, Suresh PS, Qi X, Lepp A, Mirza SP, Chen G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "22730326",
"url": "https://glygen.org/publication/PubMed/22730326"
}
]
},
{
"title": "A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation.",
"journal": "PloS one",
"date": "2012",
"authors": "Lee NV, Lira ME, Pavlicek A, Ye J, Buckman D, Bagrodia S, Srinivasa SP, Zhao Y, Aparicio S, Rejto PA, Christensen JG, Ching KA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "22745804",
"url": "https://glygen.org/publication/PubMed/22745804"
}
]
},
{
"title": "Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.",
"journal": "Open biology",
"date": "2012",
"authors": "Lapatsina L, Jira JA, Smith ES, Poole K, Kozlenkov A, Bilbao D, Lewin GR, Heppenstall PA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "22773952",
"url": "https://glygen.org/publication/PubMed/22773952"
}
]
},
{
"title": "Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.",
"journal": "Molecular and cellular biology",
"date": "2012",
"authors": "Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "22826437",
"url": "https://glygen.org/publication/PubMed/22826437"
}
]
},
{
"title": "Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling.",
"journal": "PloS one",
"date": "2012",
"authors": "Hough C, Radu M, Dore JJ",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22880011",
"url": "https://glygen.org/publication/PubMed/22880011"
}
]
},
{
"title": "FAM83B mediates EGFR- and RAS-driven oncogenic transformation.",
"journal": "J. Clin. Invest.",
"date": "2012",
"authors": "Cipriano R, Graham J, Miskimen KL, Bryson BL, Bruntz RC, Scott SA, Brown HA, Stark GR, Jackson MW",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22886302",
"url": "https://glygen.org/publication/PubMed/22886302"
}
]
},
{
"title": "Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3zeta dimer.",
"journal": "Journal of molecular biology",
"date": "2012",
"authors": "Molzan M, Ottmann C",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "22922483",
"url": "https://glygen.org/publication/PubMed/22922483"
}
]
},
{
"title": "Anoctamins are a family of Ca2+-activated Cl- channels.",
"journal": "Journal of cell science",
"date": "2012",
"authors": "Tian Y, Schreiber R, Kunzelmann K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "22946059",
"url": "https://glygen.org/publication/PubMed/22946059"
}
]
},
{
"title": "Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.",
"journal": "The Journal of biological chemistry",
"date": "1990",
"authors": "Zorzato F, Fujii J, Otsu K, Phillips M, Green NM, Lai FA, Meissner G, MacLennan DH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "2298749",
"url": "https://glygen.org/publication/PubMed/2298749"
}
]
},
{
"title": "Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.",
"journal": "The Journal of biological chemistry",
"date": "2012",
"authors": "Hayes SD, Liu H, MacDonald E, Sanderson CM, Coulson JM, Clague MJ, Urbe S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "23105109",
"url": "https://glygen.org/publication/PubMed/23105109"
}
]
},
{
"title": "Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.",
"journal": "The Journal of biological chemistry",
"date": "2012",
"authors": "Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "23112050",
"url": "https://glygen.org/publication/PubMed/23112050"
}
]
},
{
"title": "Elucidating distinct roles for NF1 in melanomagenesis.",
"journal": "Cancer discovery",
"date": "2013",
"authors": "Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "23171796",
"url": "https://glygen.org/publication/PubMed/23171796"
}
]
},
{
"title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.",
"journal": "Journal of proteome research",
"date": "2013",
"authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
}
]
},
{
"title": "Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene.",
"journal": "Somatic cell and molecular genetics",
"date": "1990",
"authors": "Fujii J, Willard HF, MacLennan DH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "2321095",
"url": "https://glygen.org/publication/PubMed/2321095"
}
]
},
{
"title": "A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.",
"journal": "Cancer discovery",
"date": "2013",
"authors": "Whittaker SR, Theurillat JP, Van Allen E, Wagle N, Hsiao J, Cowley GS, Schadendorf D, Root DE, Garraway LA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "23288408",
"url": "https://glygen.org/publication/PubMed/23288408"
}
]
},
{
"title": "MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.",
"journal": "Blood",
"date": "2013",
"authors": "Kumkhaek C, Aerbajinai W, Liu W, Zhu J, Uchida N, Kurlander R, Hsieh MM, Tisdale JF, Rodgers GP",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23327923",
"url": "https://glygen.org/publication/PubMed/23327923"
}
]
},
{
"title": "Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.",
"journal": "Molecular cell",
"date": "2013",
"authors": "Freeman AK, Ritt DA, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "23352452",
"url": "https://glygen.org/publication/PubMed/23352452"
}
]
},
{
"title": "MEK-1 activates C-Raf through a Ras-independent mechanism.",
"journal": "Biochimica et biophysica acta",
"date": "2013",
"authors": "Leicht DT, Balan V, Zhu J, Kaplun A, Bronisz A, Rana A, Tzivion G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "23360980",
"url": "https://glygen.org/publication/PubMed/23360980"
}
]
},
{
"title": "Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.",
"journal": "Cancer cell",
"date": "2013",
"authors": "Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "23453624",
"url": "https://glygen.org/publication/PubMed/23453624"
}
]
},
{
"title": "Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.",
"journal": "Circulation research",
"date": "2013",
"authors": "Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Volkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Muller OJ, Uchida T, Sussman MA",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23487407",
"url": "https://glygen.org/publication/PubMed/23487407"
}
]
},
{
"title": "Phosphodiesterase-8A binds to and regulates Raf-1 kinase.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "2013",
"authors": "Brown KM, Day JP, Huston E, Zimmermann B, Hampel K, Christian F, Romano D, Terhzaz S, Lee LC, Willis MJ, Morton DB, Beavo JA, Shimizu-Albergine M, Davies SA, Kolch W, Houslay MD, Baillie GS",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23509299",
"url": "https://glygen.org/publication/PubMed/23509299"
}
]
},
{
"title": "Endothelial RAF1/ERK activation regulates arterial morphogenesis.",
"journal": "Blood",
"date": "2013",
"authors": "Deng Y, Larrivee B, Zhuang ZW, Atri D, Moraes F, Prahst C, Eichmann A, Simons M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23529931",
"url": "https://glygen.org/publication/PubMed/23529931"
}
]
},
{
"title": "The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells.",
"journal": "PloS one",
"date": "2013",
"authors": "Jensen HA, Styskal LE, Tasseff R, Bunaciu RP, Congleton J, Varner JD, Yen A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23554907",
"url": "https://glygen.org/publication/PubMed/23554907"
}
]
},
{
"title": "Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.",
"journal": "Nature genetics",
"date": "2013",
"authors": "Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C, Parker M, Qaddoumi I, Boop FA, Lu C, Kandoth C, Ding L, Lee R, Huether R, Chen X, Hedlund E, Nagahawatte P, Rusch M, Boggs K, Cheng J, Becksfort J, Ma J, Song G, Li Y, Wei L, Wang J, Shurtleff S, Easton J, Zhao D, Fulton RS, Fulton LL, Dooling DJ, Vadodaria B, Mulder HL, Tang C, Ochoa K, Mullighan CG, Gajjar A, Kriwacki R, Sheer D, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Baker SJ, Ellison DW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "23583981",
"url": "https://glygen.org/publication/PubMed/23583981"
}
]
},
{
"title": "Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.",
"journal": "Cancer discovery",
"date": "2013",
"authors": "Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, Long B, Liu J, Dinunzio E, Windsor W, Zhang R, Zhao S, Angagaw MH, Pinheiro EM, Desai J, Xiao L, Shipps G, Hruza A, Wang J, Kelly J, Paliwal S, Gao X, Babu BS, Zhu L, Daublain P, Zhang L, Lutterbach BA, Pelletier MR, Philippar U, Siliphaivanh P, Witter D, Kirschmeier P, Bishop WR, Hicklin D, Gilliland DG, Jayaraman L, Zawel L, Fawell S, Samatar AA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "23614898",
"url": "https://glygen.org/publication/PubMed/23614898"
}
]
},
{
"title": "Crofelemer, a novel antisecretory agent approved for the treatment of HIV-associated diarrhea.",
"journal": "Drugs of today (Barcelona, Spain : 1998)",
"date": "2013",
"authors": "Yeo QM, Crutchley R, Cottreau J, Tucker A, Garey KW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "23616951",
"url": "https://glygen.org/publication/PubMed/23616951"
}
]
},
{
"title": "p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner.",
"journal": "The Journal of biological chemistry",
"date": "2013",
"authors": "Wang Z, Fu M, Wang L, Liu J, Li Y, Brakebusch C, Mei Q",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23653349",
"url": "https://glygen.org/publication/PubMed/23653349"
}
]
},
{
"title": "Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.",
"journal": "Cancer research",
"date": "2013",
"authors": "Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "23667175",
"url": "https://glygen.org/publication/PubMed/23667175"
}
]
},
{
"title": "RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.",
"journal": "Cancer cell",
"date": "2013",
"authors": "Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, Tellew J, Hardy S, Hekmat-Nejad M, Stuart DD, McCormick F, Nagel TE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802955",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955"
}
],
"reference": [
{
"type": "PubMed",
"id": "23680146",
"url": "https://glygen.org/publication/PubMed/23680146"
}
]
},
{
"title": "The dual function of KSR1: a pseudokinase and beyond.",
"journal": "Biochemical Society transactions",
"date": "2013",
"authors": "Zhang H, Koo CY, Stebbing J, Giamas G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "23863182",
"url": "https://glygen.org/publication/PubMed/23863182"
}
]
},
{
"title": "The RASopathies.",
"journal": "Annual review of genomics and human genetics",
"date": "2013",
"authors": "Rauen KA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "23875798",
"url": "https://glygen.org/publication/PubMed/23875798"
}
]
},
{
"title": "Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.",
"journal": "Journal of cellular and molecular medicine",
"date": "2013",
"authors": "Luo W, Wang X, Zheng L, Zhan Y, Zhang D, Zhang J, Zhang Y",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23905676",
"url": "https://glygen.org/publication/PubMed/23905676"
}
]
},
{
"title": "Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.",
"journal": "Journal of medicinal chemistry",
"date": "2013",
"authors": "Okaniwa M, Hirose M, Arita T, Yabuki M, Nakamura A, Takagi T, Kawamoto T, Uchiyama N, Sumita A, Tsutsumi S, Tottori T, Inui Y, Sang BC, Yano J, Aertgeerts K, Yoshida S, Ishikawa T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "23906342",
"url": "https://glygen.org/publication/PubMed/23906342"
}
]
},
{
"title": "Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.",
"journal": "Nature",
"date": "2013",
"authors": "Hatzivassiliou G, Haling JR, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "23934108",
"url": "https://glygen.org/publication/PubMed/23934108"
}
]
},
{
"title": "Hierarchical scaffolding of an ERK1/2 activation pathway.",
"journal": "Cell communication and signaling : CCS",
"date": "2013",
"authors": "Vetterkind S, Poythress RH, Lin QQ, Morgan KG",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "23987506",
"url": "https://glygen.org/publication/PubMed/23987506"
}
]
},
{
"title": "Allosteric activation of functionally asymmetric RAF kinase dimers.",
"journal": "Cell",
"date": "2013",
"authors": "Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJS, Kornev AP, Taylor SS, Shaw AS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "23993095",
"url": "https://glygen.org/publication/PubMed/23993095"
}
]
},
{
"title": "The HDAC inhibitor LBH589 induces ERK-dependent prometaphase arrest in prostate cancer via HDAC6 inactivation and down-regulation.",
"journal": "PloS one",
"date": "2013",
"authors": "Chuang MJ, Wu ST, Tang SH, Lai XM, Lai HC, Hsu KH, Sun KH, Sun GH, Chang SY, Yu DS, Hsiao PW, Huang SM, Cha TL",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24023871",
"url": "https://glygen.org/publication/PubMed/24023871"
}
]
},
{
"title": "MEK in cancer and cancer therapy.",
"journal": "Pharmacology & therapeutics",
"date": "2014",
"authors": "Neuzillet C, Tijeras-Raballand A, de Mestier L, Cros J, Faivre S, Raymond E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "24121058",
"url": "https://glygen.org/publication/PubMed/24121058"
}
]
},
{
"title": "Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma.",
"journal": "Cancer research",
"date": "2013",
"authors": "Nakamura A, Arita T, Tsuchiya S, Donelan J, Chouitar J, Carideo E, Galvin K, Okaniwa M, Ishikawa T, Yoshida S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "24121489",
"url": "https://glygen.org/publication/PubMed/24121489"
}
]
},
{
"title": "Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.",
"journal": "The Journal of clinical investigation",
"date": "2013",
"authors": "Ricarte-Filho JC, Li S, Garcia-Rendueles ME, Montero-Conde C, Voza F, Knauf JA, Heguy A, Viale A, Bogdanova T, Thomas GA, Mason CE, Fagin JA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "24135138",
"url": "https://glygen.org/publication/PubMed/24135138"
}
]
},
{
"title": "Tumor adaptation and resistance to RAF inhibitors.",
"journal": "Nature medicine",
"date": "2013",
"authors": "Lito P, Rosen N, Solit DB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "24202393",
"url": "https://glygen.org/publication/PubMed/24202393"
}
]
},
{
"title": "An MRAS, SHOC2, and SCRIB complex coordinates ERK pathway activation with polarity and tumorigenic growth.",
"journal": "Molecular cell",
"date": "2013",
"authors": "Young LC, Hartig N, Munoz-Alegre M, Oses-Prieto JA, Durdu S, Bender S, Vijayakumar V, Vietri Rudan M, Gewinner C, Henderson S, Jathoul AP, Ghatrora R, Lythgoe MF, Burlingame AL, Rodriguez-Viciana P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "24211266",
"url": "https://glygen.org/publication/PubMed/24211266"
}
]
},
{
"title": "Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation.",
"journal": "The FEBS journal",
"date": "2014-02",
"authors": "Geil Wendy M, Yen Andrew",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24330068",
"url": "https://glygen.org/publication/PubMed/24330068"
}
]
},
{
"title": "BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition.",
"journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
"date": "2013",
"authors": "Hutchinson KE, Lipson D, Stephens PJ, Otto G, Lehmann BD, Lyle PL, Vnencak-Jones CL, Ross JS, Pietenpol JA, Sosman JA, Puzanov I, Miller VA, Pao W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "24345920",
"url": "https://glygen.org/publication/PubMed/24345920"
}
]
},
{
"title": "Prohibitins role in cellular survival through Ras-Raf-MEK-ERK pathway.",
"journal": "Journal of cellular physiology",
"date": "2014",
"authors": "Chowdhury I, Thompson WE, Thomas K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "24347342",
"url": "https://glygen.org/publication/PubMed/24347342"
}
]
},
{
"title": "Targeting the prohibitin scaffold-CRAF kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma.",
"journal": "Molecular cancer",
"date": "2014",
"authors": "Luan Z, He Y, Alattar M, Chen Z, He F",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24568222",
"url": "https://glygen.org/publication/PubMed/24568222"
}
]
},
{
"title": "Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.",
"journal": "Cell death & disease",
"date": "2014",
"authors": "Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24625973",
"url": "https://glygen.org/publication/PubMed/24625973"
}
]
},
{
"title": "Dragging ras back in the ring.",
"journal": "Cancer cell",
"date": "2014",
"authors": "Stephen AG, Esposito D, Bagni RK, McCormick F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9649948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948"
}
],
"reference": [
{
"type": "PubMed",
"id": "24651010",
"url": "https://glygen.org/publication/PubMed/24651010"
}
]
},
{
"title": "RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression.",
"journal": "Molecular and cellular biology",
"date": "2014",
"authors": "Ram RR, Mendiratta S, Bodemann BO, Torres MJ, Eskiocak U, White MA",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24732797",
"url": "https://glygen.org/publication/PubMed/24732797"
}
]
},
{
"title": "Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.",
"journal": "Cancer cell",
"date": "2014",
"authors": "Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "24746704",
"url": "https://glygen.org/publication/PubMed/24746704"
}
]
},
{
"title": "RAF1 mutations in childhood-onset dilated cardiomyopathy.",
"journal": "Nature genetics",
"date": "2014",
"authors": "Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, Nishizawa T, Nakanishi T, Robbins J, Limongelli G, Hajjar RJ, Lebeche D, Bahl A, Khullar M, Rathinavel A, Sadler KC, Tartaglia M, Matsuoka R, Thangaraj K, Gelb BD",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24777450",
"url": "https://glygen.org/publication/PubMed/24777450"
}
]
},
{
"title": "Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling.",
"journal": "Cell death & disease",
"date": "2014",
"authors": "Liu D, Huang Y, Bu D, Liu AD, Holmberg L, Jia Y, Tang C, Du J, Jin H",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24853429",
"url": "https://glygen.org/publication/PubMed/24853429"
}
]
},
{
"title": "Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts.",
"journal": "PloS one",
"date": "2014",
"authors": "Jensen HA, Bunaciu RP, Ibabao CN, Myers R, Varner JD, Yen A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24922062",
"url": "https://glygen.org/publication/PubMed/24922062"
}
]
},
{
"title": "Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.",
"journal": "Nature cell biology",
"date": "2014",
"authors": "Romano D, Nguyen LK, Matallanas D, Halasz M, Doherty C, Kholodenko BN, Kolch W",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "24929361",
"url": "https://glygen.org/publication/PubMed/24929361"
}
]
},
{
"title": "`RAF` neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway.",
"journal": "FEBS letters",
"date": "2014",
"authors": "Cseh B, Doma E, Baccarini M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "24937142",
"url": "https://glygen.org/publication/PubMed/24937142"
}
]
},
{
"title": "Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.",
"journal": "Nature reviews. Cancer",
"date": "2014",
"authors": "Holderfield M, Deuker MM, McCormick F, McMahon M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802946",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946"
}
],
"reference": [
{
"type": "PubMed",
"id": "24957944",
"url": "https://glygen.org/publication/PubMed/24957944"
}
]
},
{
"title": "A Novel SHOC2 Variant in Rasopathy.",
"journal": "Human mutation",
"date": "2014",
"authors": "Hannig V, Jeoung M, Jang ER, Phillips JA 3rd, Galperin E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9726840",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726840"
}
],
"reference": [
{
"type": "PubMed",
"id": "25137548",
"url": "https://glygen.org/publication/PubMed/25137548"
}
]
},
{
"title": "A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.",
"journal": "Nature chemical biology",
"date": "2014",
"authors": "Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "25195011",
"url": "https://glygen.org/publication/PubMed/25195011"
}
]
},
{
"title": "Protein microarray for complex apoptosis monitoring of dysplastic oral keratinocytes in experimental photodynamic therapy.",
"journal": "Biological research",
"date": "2014",
"authors": "Matei C, Tampa M, Caruntu C, Ion RM, Georgescu SR, Dumitrascu GR, Constantin C, Neagu M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "25204017",
"url": "https://glygen.org/publication/PubMed/25204017"
}
]
},
{
"title": "The landscape of kinase fusions in cancer.",
"journal": "Nature communications",
"date": "2014",
"authors": "Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802952",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952"
}
],
"reference": [
{
"type": "PubMed",
"id": "25204415",
"url": "https://glygen.org/publication/PubMed/25204415"
}
]
},
{
"title": "Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.",
"journal": "Journal of medicinal chemistry",
"date": "2014",
"authors": "Deng Y, Shipps GW Jr, Cooper A, English JM, Annis DA, Carr D, Nan Y, Wang T, Zhu HY, Chuang CC, Dayananth P, Hruza AW, Xiao L, Jin W, Kirschmeier P, Windsor WT, Samatar AA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "25313996",
"url": "https://glygen.org/publication/PubMed/25313996"
}
]
},
{
"title": "Reciprocal allosteric regulation of p38gamma and PTPN3 involves a PDZ domain-modulated complex formation.",
"journal": "Science signaling",
"date": "2014",
"authors": "Chen KE, Lin SY, Wu MJ, Ho MR, Santhanam A, Chou CC, Meng TC, Wang AH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "25314968",
"url": "https://glygen.org/publication/PubMed/25314968"
}
]
},
{
"title": "Calmodulin modulation of single sarcoplasmic reticulum Ca2+-release channels from cardiac and skeletal muscle.",
"journal": "Circulation research",
"date": "1989",
"authors": "Smith JS, Rousseau E, Meissner G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "2536303",
"url": "https://glygen.org/publication/PubMed/2536303"
}
]
},
{
"title": "Targeting RAS-ERK signalling in cancer: promises and challenges.",
"journal": "Nature reviews. Drug discovery",
"date": "2014",
"authors": "Samatar AA, Poulikakos PI",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802946",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946"
}
],
"reference": [
{
"type": "PubMed",
"id": "25435214",
"url": "https://glygen.org/publication/PubMed/25435214"
}
]
},
{
"title": "RKIP: a governor of intracellular signaling.",
"journal": "Critical reviews in oncogenesis",
"date": "2014",
"authors": "Lorenz K, Schmid E, Deiss K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5675221",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221"
}
],
"reference": [
{
"type": "PubMed",
"id": "25597358",
"url": "https://glygen.org/publication/PubMed/25597358"
}
]
},
{
"title": "Regulation of RAF protein kinases in ERK signalling.",
"journal": "Nature reviews. Molecular cell biology",
"date": "2015",
"authors": "Lavoie H, Therrien M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-6802948",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948"
}
],
"reference": [
{
"type": "PubMed",
"id": "25907612",
"url": "https://glygen.org/publication/PubMed/25907612"
}
]
},
{
"title": "Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.",
"journal": "Journal of medicinal chemistry",
"date": "2015",
"authors": "Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "25965804",
"url": "https://glygen.org/publication/PubMed/25965804"
}
]
},
{
"title": "Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation.",
"journal": "Marine drugs",
"date": "2015",
"authors": "Josse R, Zhang YW, Giroux V, Ghosh AK, Luo J, Pommier Y",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26058013",
"url": "https://glygen.org/publication/PubMed/26058013"
}
]
},
{
"title": "Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy.",
"journal": "Cancer research",
"date": "2015",
"authors": "Tsai YT, Chuang MJ, Tang SH, Wu ST, Chen YC, Sun GH, Hsiao PW, Huang SM, Lee HJ, Yu CP, Ho JY, Lin HK, Chen MR, Lin CC, Chang SY, Lin VC, Yu DS, Cha TL",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26100670",
"url": "https://glygen.org/publication/PubMed/26100670"
}
]
},
{
"title": "IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.",
"journal": "Scientific reports",
"date": "2015",
"authors": "Mombelli S, Cochaud S, Merrouche Y, Garbar C, Antonicelli F, Laprevotte E, Alberici G, Bonnefoy N, Eliaou JF, Bastid J, Bensussan A, Giustiniani J",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26154409",
"url": "https://glygen.org/publication/PubMed/26154409"
}
]
},
{
"title": "Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.",
"journal": "Nature genetics",
"date": "2015",
"authors": "Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9656223",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223"
}
],
"reference": [
{
"type": "PubMed",
"id": "26214590",
"url": "https://glygen.org/publication/PubMed/26214590"
}
]
},
{
"title": "Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells.",
"journal": "Respiratory research",
"date": "2015",
"authors": "Jiang S, Tang DD",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26242183",
"url": "https://glygen.org/publication/PubMed/26242183"
}
]
},
{
"title": "Biophysical Characterization of Essential Phosphorylation at the Flexible C-Terminal Region of C-Raf with 14-3-3zeta Protein.",
"journal": "PloS one",
"date": "2015",
"authors": "Ghosh A, Ratha BN, Gayen N, Mroue KH, Kar RK, Mandal AK, Bhunia A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26295714",
"url": "https://glygen.org/publication/PubMed/26295714"
}
]
},
{
"title": "Kinase-independent role for CRAF-driving tumour radioresistance via CHK2.",
"journal": "Nature communications",
"date": "2015",
"authors": "Advani SJ, Camargo MF, Seguin L, Mielgo A, Anand S, Hicks AM, Aguilera J, Franovic A, Weis SM, Cheresh DA",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26333361",
"url": "https://glygen.org/publication/PubMed/26333361"
}
]
},
{
"title": "Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.",
"journal": "Cancer cell",
"date": "2015",
"authors": "Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y, Van Horn RD, Yin T, Zhang X, Yadav V, Chen SH, Gong X, Ma X, Webster Y, Buchanan S, Mochalkin I, Huber L, Kays L, Donoho GP, Walgren J, McCann D, Patel P, Conti I, Plowman GD, Starling JJ, Flynn DL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "26343583",
"url": "https://glygen.org/publication/PubMed/26343583"
}
]
},
{
"title": "A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.",
"journal": "American journal of physiology. Gastrointestinal and liver physiology",
"date": "2015",
"authors": "Strege PR, Bernard CE, Mazzone A, Linden DR, Beyder A, Gibbons SJ, Farrugia G",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "26359375",
"url": "https://glygen.org/publication/PubMed/26359375"
}
]
},
{
"title": "Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion.",
"journal": "ASN neuro",
"date": "2015",
"authors": "Zhou J, Du T, Li B, Rong Y, Verkhratsky A, Peng L",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26442853",
"url": "https://glygen.org/publication/PubMed/26442853"
}
]
},
{
"title": "Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker.",
"journal": "British journal of pharmacology",
"date": "2016",
"authors": "Ta CM, Adomaviciene A, Rorsman NJ, Garnett H, Tammaro P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "26562072",
"url": "https://glygen.org/publication/PubMed/26562072"
}
]
},
{
"title": "Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway.",
"journal": "Oncotarget",
"date": "2016",
"authors": "Wang T, Seah S, Loh X, Chan CW, Hartman M, Goh BC, Lee SC",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26565813",
"url": "https://glygen.org/publication/PubMed/26565813"
}
]
},
{
"title": "Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.",
"journal": "PloS one",
"date": "2015",
"authors": "Holehouse AS, Naegle KM",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "26659599",
"url": "https://glygen.org/publication/PubMed/26659599"
}
]
},
{
"title": "Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.",
"journal": "Cell",
"date": "2016",
"authors": "Yang Xinping, Coulombe-Huntington Jasmin, Kang Shuli, Sheynkman Gloria M, Hao Tong, Richardson Aaron, Sun Song, Yang Fan, Shen Yun A, Murray Ryan R, Spirohn Kerstin, Begg Bridget E, Duran-Frigola Miquel, MacWilliams Andrew, Pevzner Samuel J, Zhong Quan, Trigg Shelly A, Tam Stanley, Ghamsari Lila, Sahni Nidhi, Yi Song, Rodriguez Maria D, Balcha Dawit, Tan Guihong, Costanzo Michael, Andrews Brenda, Boone Charles, Zhou Xianghong J, Salehi-Ashtiani Kourosh, Charloteaux Benoit, Chen Alyce A, Calderwood Michael A, Aloy Patrick, Roth Frederick P, Hill David E, Iakoucheva Lilia M, Xia Yu, Vidal Marc",
"evidence": [
{
"database": "UniProtKB",
"id": "A0A0S2Z4L5",
"url": "https://www.uniprot.org/uniprot/A0A0S2Z4L5"
}
],
"reference": [
{
"type": "PubMed",
"id": "26871637",
"url": "https://glygen.org/publication/PubMed/26871637"
}
]
},
{
"title": "Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling.",
"journal": "eLife",
"date": "2016",
"authors": "Wu J, Ivanov AI, Fisher PB, Fu Z",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "27003818",
"url": "https://glygen.org/publication/PubMed/27003818"
}
]
},
{
"title": "Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-y l)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.",
"journal": "Journal of medicinal chemistry",
"date": "2016",
"authors": "Blake JF, Burkard M, Chan J, Chen H, Chou KJ, Diaz D, Dudley DA, Gaudino JJ, Gould SE, Grina J, Hunsaker T, Liu L, Martinson M, Moreno D, Mueller L, Orr C, Pacheco P, Qin A, Rasor K, Ren L, Robarge K, Shahidi-Latham S, Stults J, Sullivan F, Wang W, Yin J, Zhou A, Belvin M, Merchant M, Moffat J, Schwarz JB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "27227380",
"url": "https://glygen.org/publication/PubMed/27227380"
}
]
},
{
"title": "A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.",
"journal": "American journal of medical genetics. Part A",
"date": "2016",
"authors": "Gripp KW, Aldinger KA, Bennett JT, Baker L, Tusi J, Powell-Hamilton N, Stabley D, Sol-Church K, Timms AE, Dobyns WB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "27264673",
"url": "https://glygen.org/publication/PubMed/27264673"
}
]
},
{
"title": "RRD-251 enhances all-trans retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells.",
"journal": "Oncotarget",
"date": "2016",
"authors": "Wallace AS, Supnick HT, Bunaciu RP, Yen A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "27331409",
"url": "https://glygen.org/publication/PubMed/27331409"
}
]
},
{
"title": "SHOC2 subcellular shuttling requires the KEKE motif-rich region and N-terminal leucine-rich repeat domain and impacts on ERK signalling.",
"journal": "Human molecular genetics",
"date": "2016",
"authors": "Motta M, Chillemi G, Fodale V, Cecchetti S, Coppola S, Stipo S, Cordeddu V, Macioce P, Gelb BD, Tartaglia M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9726842",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842"
}
],
"reference": [
{
"type": "PubMed",
"id": "27466182",
"url": "https://glygen.org/publication/PubMed/27466182"
}
]
},
{
"title": "Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis.",
"journal": "Genes",
"date": "2016",
"authors": "Shin SY, Nguyen LK",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "27527217",
"url": "https://glygen.org/publication/PubMed/27527217"
}
]
},
{
"title": "Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERK signaling via PKA and Epac pathways in human lung cancer cells.",
"journal": "Experimental & molecular medicine",
"date": "2016",
"authors": "Lim JA, Juhnn YS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "27534532",
"url": "https://glygen.org/publication/PubMed/27534532"
}
]
},
{
"title": "LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.",
"journal": "Oncotarget",
"date": "2017",
"authors": "Vakana E, Pratt S, Blosser W, Dowless M, Simpson N, Yuan XJ, Jaken S, Manro J, Stephens J, Zhang Y, Huber L, Peng SB, Stancato LF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "27999210",
"url": "https://glygen.org/publication/PubMed/27999210"
}
]
},
{
"title": "Integrating mass spectrometry with MD simulations reveals the role of lipids in Na(+)/H(+) antiporters.",
"journal": "Nature communications",
"date": "2017",
"authors": "Landreh M, Marklund EG, Uzdavinys P, Degiacomi MT, Coincon M, Gault J, Gupta K, Liko I, Benesch JL, Drew D, Robinson CV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "28071645",
"url": "https://glygen.org/publication/PubMed/28071645"
}
]
},
{
"title": "A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.",
"journal": "Neuro-oncology",
"date": "2017",
"authors": "Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "28082416",
"url": "https://glygen.org/publication/PubMed/28082416"
}
]
},
{
"title": "Dissecting the proton transport pathway in electrogenic Na(+)/H(+) antiporters.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2017",
"authors": "Uzdavinys P, Coincon M, Nji E, Ndi M, Winkelmann I, von Ballmoos C, Drew D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "28154142",
"url": "https://glygen.org/publication/PubMed/28154142"
}
]
},
{
"title": "Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.",
"journal": "JCI insight",
"date": "2017",
"authors": "Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "28289718",
"url": "https://glygen.org/publication/PubMed/28289718"
}
]
},
{
"title": "RAS Proteins and Their Regulators in Human Disease.",
"journal": "Cell",
"date": "2017",
"authors": "Simanshu DK, Nissley DV, McCormick F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "28666118",
"url": "https://glygen.org/publication/PubMed/28666118"
}
]
},
{
"title": "Phosphorylation of the C-Raf N Region Promotes Raf Dimerization.",
"journal": "Molecular and cellular biology",
"date": "2017-10-01",
"authors": "Takahashi Maho, Li Yanping, Dillon Tara J, Kariya Yumi, Stork Philip J S",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "28694330",
"url": "https://glygen.org/publication/PubMed/28694330"
}
]
},
{
"title": "Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells.",
"journal": "Scientific reports",
"date": "2017",
"authors": "Xu JJ, Elkaddi N, Garcia-Blanco A, Spielman AI, Bachmanov AA, Chung HY, Ozdener MH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "28790369",
"url": "https://glygen.org/publication/PubMed/28790369"
}
]
},
{
"title": "Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).",
"journal": "Molecular cancer therapeutics",
"date": "2017",
"authors": "Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "28939558",
"url": "https://glygen.org/publication/PubMed/28939558"
}
]
},
{
"title": "Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib.",
"journal": "Oncotarget",
"date": "2017",
"authors": "Noeparast A, Teugels E, Giron P, Verschelden G, De Brakeleer S, Decoster L, De Greve J",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "28947956",
"url": "https://glygen.org/publication/PubMed/28947956"
}
]
},
{
"title": "New perspectives for targeting RAF kinase in human cancer.",
"journal": "Nature reviews. Cancer",
"date": "2017",
"authors": "Karoulia Z, Gavathiotis E, Poulikakos PI",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "28984291",
"url": "https://glygen.org/publication/PubMed/28984291"
}
]
},
{
"title": "Dasatinib synergizes with ATRA to trigger granulocytic differentiation in ATRA resistant acute promyelocytic leukemia cell lines via Lyn inhibition-mediated activation of RAF-1/MEK/ERK.",
"journal": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association",
"date": "2018-09",
"authors": "Ding Ming, Weng Xiang-Qin, Sheng Yan, Wu Jing, Liang Cui, Cai Xun",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "29097117",
"url": "https://glygen.org/publication/PubMed/29097117"
}
]
},
{
"title": "Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.",
"journal": "EMBO J.",
"date": "2017",
"authors": "Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "29127155",
"url": "https://glygen.org/publication/PubMed/29127155"
}
]
},
{
"title": "The novel RAF1 mutation p.(Gly361Ala) located outside the kinase domain of the CR3 region in two patients with Noonan syndrome, including one with a rare brain tumor.",
"journal": "American journal of medical genetics. Part A",
"date": "2018",
"authors": "Harms FL, Alawi M, Amor DJ, Tan TY, Cuturilo G, Lissewski C, Brinkmann J, Schanze D, Kutsche K, Zenker M",
"evidence": [
{
"database": "Entrez",
"id": "5894",
"url": "https://www.ncbi.nlm.nih.gov/gene/5894"
}
],
"reference": [
{
"type": "PubMed",
"id": "29271604",
"url": "https://glygen.org/publication/PubMed/29271604"
}
]
},
{
"title": "Current Insights of BRAF Inhibitors in Cancer.",
"journal": "Journal of medicinal chemistry",
"date": "2018",
"authors": "Agianian B, Gavathiotis E",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "29461827",
"url": "https://glygen.org/publication/PubMed/29461827"
}
]
},
{
"title": "Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.",
"journal": "JCI insight",
"date": "2018",
"authors": "Moschos SJ, Sullivan RJ, Hwu WJ, Ramanathan RK, Adjei AA, Fong PC, Shapira-Frommer R, Tawbi HA, Rubino J, Rush TS 3rd, Zhang D, Miselis NR, Samatar AA, Chun P, Rubin EH, Schiller J, Long BJ, Dayananth P, Carr D, Kirschmeier P, Bishop WR, Deng Y, Cooper A, Shipps GW, Moreno BH, Robert L, Ribas A, Flaherty KT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "29467321",
"url": "https://glygen.org/publication/PubMed/29467321"
}
]
},
{
"title": "The c-Raf modulator RRD-251 enhances nuclear c-Raf/GSK-3/VDR axis signaling and augments 1,25-dihydroxyvitamin D3-induced differentiation of HL-60 myeloblastic leukemia cells.",
"journal": "Oncotarget",
"date": "2018",
"authors": "Supnick HT, Bunaciu RP, Yen A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "29515772",
"url": "https://glygen.org/publication/PubMed/29515772"
}
]
},
{
"title": "RUVBL1, a novel C-RAF-binding protein, activates the RAF/MEK/ERK pathway to promote lung cancer tumorigenesis.",
"journal": "Biochemical and biophysical research communications",
"date": "2018",
"authors": "Guo H, Zhang XY, Peng J, Huang Y, Yang Y, Liu Y, Guo XX, Hao Q, An S, Xu TR",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "29545175",
"url": "https://glygen.org/publication/PubMed/29545175"
}
]
},
{
"title": "Type II RAF inhibitor causes superior ERK pathway suppression compared to type I RAF inhibitor in cells expressing different BRAF mutant types recurrently found in lung cancer.",
"journal": "Oncotarget",
"date": "2018",
"authors": "Noeparast A, Giron P, De Brakeleer S, Eggermont C, De Ridder U, Teugels E, De Greve J",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "29662630",
"url": "https://glygen.org/publication/PubMed/29662630"
}
]
},
{
"title": "KAP1 inhibits the Raf-MEK-ERK pathway to promote tumorigenesis in A549 lung cancer cells.",
"journal": "Molecular carcinogenesis",
"date": "2018",
"authors": "Wu GJ, Pen J, Huang Y, An S, Liu Y, Yang Y, Hao Q, Guo XX, Xu TR",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "29917268",
"url": "https://glygen.org/publication/PubMed/29917268"
}
]
},
{
"title": "Structure and biological activity of human homologs of the raf/mil oncogene.",
"journal": "Mol. Cell. Biol.",
"date": "1985",
"authors": "Bonner T I, Kerby S B, Sutrave P, Gunnell M A, Mark G, Rapp U R",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "2993863",
"url": "https://glygen.org/publication/PubMed/2993863"
}
]
},
{
"title": "MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.",
"journal": "ACS medicinal chemistry letters",
"date": "2018",
"authors": "Boga SB, Deng Y, Zhu L, Nan Y, Cooper AB, Shipps GW Jr, Doll R, Shih NY, Zhu H, Sun R, Wang T, Paliwal S, Tsui HC, Gao X, Yao X, Desai J, Wang J, Alhassan AB, Kelly J, Patel M, Muppalla K, Gudipati S, Zhang LK, Buevich A, Hesk D, Carr D, Dayananth P, Black S, Mei H, Cox K, Sherborne B, Hruza AW, Xiao L, Jin W, Long B, Liu G, Taylor SA, Kirschmeier P, Windsor WT, Bishop R, Samatar AA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "30034615",
"url": "https://glygen.org/publication/PubMed/30034615"
}
]
},
{
"title": "The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene.",
"journal": "Nucleic Acids Res.",
"date": "1986",
"authors": "Bonner T I, Oppermann H, Seeburg P, Kerby S B, Gunnell M A, Young A C, Rapp U R",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "3003687",
"url": "https://glygen.org/publication/PubMed/3003687"
}
]
},
{
"title": "SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2018",
"authors": "Young LC, Hartig N, Boned Del Rio I, Sari S, Ringham-Terry B, Wainwright JR, Jones GG, McCormick F, Rodriguez-Viciana P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9726842",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842"
}
],
"reference": [
{
"type": "PubMed",
"id": "30348783",
"url": "https://glygen.org/publication/PubMed/30348783"
}
]
},
{
"title": "Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.",
"journal": "Hum. Genet.",
"date": "2019",
"authors": "Umeki I, Niihori T, Abe T, Kanno SI, Okamoto N, Mizuno S, Kurosawa K, Nagasaki K, Yoshida M, Ohashi H, Inoue SI, Matsubara Y, Fujiwara I, Kure S, Aoki Y",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "30368668",
"url": "https://glygen.org/publication/PubMed/30368668"
}
]
},
{
"title": "Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells.",
"journal": "Molecular biology of the cell",
"date": "2019",
"authors": "Surve SV, Myers PJ, Clayton SA, Watkins SC, Lazzara MJ, Sorkin A",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "30586319",
"url": "https://glygen.org/publication/PubMed/30586319"
}
]
},
{
"title": "Targeting ERK1/2 protein-serine/threonine kinases in human cancers.",
"journal": "Pharmacological research",
"date": "2019",
"authors": "Roskoski R Jr",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "30794926",
"url": "https://glygen.org/publication/PubMed/30794926"
}
]
},
{
"title": "Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A - C-Raf.",
"journal": "BMC cancer",
"date": "2019",
"authors": "Blair CM, Walsh NM, Littman BH, Marcoux FW, Baillie GS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "30909892",
"url": "https://glygen.org/publication/PubMed/30909892"
}
]
},
{
"title": "Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells.",
"journal": "Cell communication and signaling : CCS",
"date": "2019",
"authors": "Chen L, Bi S, Hou J, Zhao Z, Wang C, Xie S",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "30971268",
"url": "https://glygen.org/publication/PubMed/30971268"
}
]
},
{
"title": "A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway.",
"journal": "Front. Physiol.",
"date": "2019",
"authors": "Popov IK, Hiatt SM, Whalen S, Keren B, Ruivenkamp C, van Haeringen A, Chen MJ, Cooper GM, Korf BR, Chang C",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31024343",
"url": "https://glygen.org/publication/PubMed/31024343"
}
]
},
{
"title": "Clinical and functional characterization of a novel RASopathy-causing SHOC2 mutation associated with prenatal-onset hypertrophic cardiomyopathy.",
"journal": "Human mutation",
"date": "2019",
"authors": "Motta M, Giancotti A, Mastromoro G, Chandramouli B, Pinna V, Pantaleoni F, Di Giosaffatte N, Petrini S, Mazza T, D'Ambrosio V, Versacci P, Ventriglia F, Chillemi G, Pizzuti A, Tartaglia M, De Luca A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9726842",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842"
}
],
"reference": [
{
"type": "PubMed",
"id": "31059601",
"url": "https://glygen.org/publication/PubMed/31059601"
}
]
},
{
"title": "VCP/p97 controls signals of the ERK1/2 pathway transmitted via the Shoc2 scaffolding complex: novel insights into IBMPFD pathology.",
"journal": "Molecular biology of the cell",
"date": "2019",
"authors": "Jang H, Jang ER, Wilson PG, Anderson D, Galperin E",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31091164",
"url": "https://glygen.org/publication/PubMed/31091164"
}
]
},
{
"title": "Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.",
"journal": "Human molecular genetics",
"date": "2020",
"authors": "Motta M, Sagi-Dain L, Krumbach OHF, Hahn A, Peleg A, German A, Lissewski C, Coppola S, Pantaleoni F, Kocherscheid L, Altmuller F, Schanze D, Logeswaran T, Chahrokh-Zadeh S, Munzig A, Nakhaei-Rad S, Cave H, Ahmadian MR, Tartaglia M, Zenker M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9726842",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842"
}
],
"reference": [
{
"type": "PubMed",
"id": "31108500",
"url": "https://glygen.org/publication/PubMed/31108500"
}
]
},
{
"title": "SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2019",
"authors": "Boned Del Rio I, Young LC, Sari S, Jones GG, Ringham-Terry B, Hartig N, Rejnowicz E, Lei W, Bhamra A, Surinova S, Rodriguez-Viciana P",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31213532",
"url": "https://glygen.org/publication/PubMed/31213532"
}
]
},
{
"title": "CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition.",
"journal": "Oncogene",
"date": "2019",
"authors": "Noeparast A, Giron P, Noor A, Bahadur Shahi R, De Brakeleer S, Eggermont C, Vandenplas H, Boeckx B, Lambrechts D, De Greve J, Teugels E",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31285551",
"url": "https://glygen.org/publication/PubMed/31285551"
}
]
},
{
"title": "O-GlcNAcylation of RAF1 increases its stabilization and induces the renal fibrosis.",
"journal": "Biochimica et biophysica acta. Molecular basis of disease",
"date": "2020",
"authors": "Feng D, Sheng-Dong L, Tong W, Zhen-Xian D",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "P04049",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04049"
},
{
"database": "O-GlcNAc Atlas",
"id": "P04049",
"url": "https://oglcnac.org/atlas/detail/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31521821",
"url": "https://glygen.org/publication/PubMed/31521821"
}
]
},
{
"title": "RAF kinases are stabilized and required for dendritic cell differentiation and function.",
"journal": "Cell death and differentiation",
"date": "2020-04",
"authors": "Riegel Kristina, Schl\u00f6der Janine, Sobczak Marco, Jonuleit Helmut, Thiede Bernd, Schild Hansj\u00f6rg, Rajalingam Krishnaraj",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31541179",
"url": "https://glygen.org/publication/PubMed/31541179"
}
]
},
{
"title": "On the association of glycoprotein Ib and actin-binding protein in human platelets.",
"journal": "The Journal of cell biology",
"date": "1985",
"authors": "Okita JR, Pidard D, Newman PJ, Montgomery RR, Kunicki TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "3155520",
"url": "https://glygen.org/publication/PubMed/3155520"
}
]
},
{
"title": "miR489 promotes apoptosis and inhibits invasiveness of glioma cells by targeting PAK5/RAF1 signaling pathways.",
"journal": "Oncology reports",
"date": "2019",
"authors": "Wang W, Zhang L, Gao W, Zhang D, Zhao Z, Bao Y",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31638257",
"url": "https://glygen.org/publication/PubMed/31638257"
}
]
},
{
"title": "Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer.",
"journal": "BMC cancer",
"date": "2019",
"authors": "Kizilboga T, Baskale EA, Yildiz J, Akcay IM, Zemheri E, Can ND, Ozden C, Demir S, Ezberci F, Dinler-Doganay G",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "31883527",
"url": "https://glygen.org/publication/PubMed/31883527"
}
]
},
{
"title": "Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1988",
"authors": "Ray LB, Sturgill TW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "3287375",
"url": "https://glygen.org/publication/PubMed/3287375"
}
]
},
{
"title": "The crosstalk network of XIST/miR-424-5p/OGT mediates RAF1 glycosylation and participates in the progression of liver cancer.",
"journal": "Liver international : official journal of the International Association for the Study of the Liver",
"date": "2021",
"authors": "Ning D, Chen J, Du P, Liu Q, Cheng Q, Li X, Zhang B, Chen X, Jiang L",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "P04049",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "33909326",
"url": "https://glygen.org/publication/PubMed/33909326"
}
]
},
{
"title": "TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1.",
"journal": "Experimental & molecular medicine",
"date": "2023-06",
"authors": "Fei Xiaowei, Dou Ya-Nan, Sun Kai, Wei Jialiang, Guo Qingdong, Wang Li, Wu Xiuquan, Lv Weihao, Jiang Xiaofan, Fei Zhou",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
}
],
"reference": [
{
"type": "PubMed",
"id": "37258577",
"url": "https://glygen.org/publication/PubMed/37258577"
}
]
},
{
"title": "Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues.",
"journal": "Communications biology",
"date": "2023-06-21",
"authors": "Nakhaei-Rad Saeideh, Haghighi Fereshteh, Bazgir Farhad, Dahlmann Julia, Busley Alexandra Viktoria, Buchholzer Marcel, Kleemann Karolin, Sch\u00e4nzer Anne, Borchardt Andrea, Hahn Andreas, K\u00f6tter Sebastian, Schanze Denny, Anand Ruchika, Funk Florian, Kronenbitter Annette Vera, Scheller J\u00fcrgen, Piekorz Roland P, Reichert Andreas S, Volleth Marianne, Wolf Matthew J, Cirstea Ion Cristian, Gelb Bruce D, Tartaglia Marco, Schmitt Joachim P, Kr\u00fcger Martina, Kutschka Ingo, Cyganek Lukas, Zenker Martin, Kensah George, Ahmadian Mohammad R",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
}
],
"reference": [
{
"type": "PubMed",
"id": "37344639",
"url": "https://glygen.org/publication/PubMed/37344639"
}
]
},
{
"title": "Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.",
"journal": "Brain pathology (Zurich, Switzerland)",
"date": "2023-09",
"authors": "Benhamida Jamal K, Harmsen Hannah J, Ma Deqin, William Christopher M, Li Bryan K, Villafania Liliana, Sukhadia Purvil, Mullaney Kerry A, Dewan Michael C, Vakiani Efsevia, Karajannis Matthias A, Snuderl Matija, Zagzag David, Ladanyi Marc, Rosenblum Marc K, Bale Tejus A",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
}
],
"reference": [
{
"type": "PubMed",
"id": "37399073",
"url": "https://glygen.org/publication/PubMed/37399073"
}
]
},
{
"title": "PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis.",
"journal": "Biomolecules",
"date": "2023-12-04",
"authors": "Kirkbride Jason A, Nilsson Garbo Young, Kim Jee In, Takeya Kosuke, Tanaka Yoshinori, Tokumitsu Hiroshi, Suizu Futoshi, Eto Masumi",
"evidence": [
{
"database": "RefSeq",
"id": "NP_002871",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_002871"
}
],
"reference": [
{
"type": "PubMed",
"id": "38136612",
"url": "https://glygen.org/publication/PubMed/38136612"
}
]
},
{
"title": "Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion.",
"journal": "Blood",
"date": "1985",
"authors": "Turitto VT, Weiss HJ, Zimmerman TS, Sussman II",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "3872140",
"url": "https://glygen.org/publication/PubMed/3872140"
}
]
},
{
"title": "Phosphorylation of Raf by ceramide-activated protein kinase.",
"journal": "Nature",
"date": "1995",
"authors": "Yao B, Zhang Y, Delikat S, Mathias S, Basu S, Kolesnick R",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "7477354",
"url": "https://glygen.org/publication/PubMed/7477354"
}
]
},
{
"title": "Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Cleghon V, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "7517401",
"url": "https://glygen.org/publication/PubMed/7517401"
}
]
},
{
"title": "Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.",
"journal": "The EMBO journal",
"date": "1995",
"authors": "Marais R, Light Y, Paterson HF, Marshall CJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "7542586",
"url": "https://glygen.org/publication/PubMed/7542586"
}
]
},
{
"title": "A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.",
"journal": "Molecular and cellular biology",
"date": "1995",
"authors": "Catling AD, Schaeffer HJ, Reuter CW, Reddy GR, Weber MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "7565670",
"url": "https://glygen.org/publication/PubMed/7565670"
}
]
},
{
"title": "Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells.",
"journal": "Molecular and cellular biology",
"date": "1995",
"authors": "Pritchard CA, Samuels ML, Bosch E, McMahon M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "7565795",
"url": "https://glygen.org/publication/PubMed/7565795"
}
]
},
{
"title": "Molecular cloning of the cDNA encoding human skeletal muscle triadin and its localisation to chromosome 6q22-6q23.",
"journal": "European journal of biochemistry",
"date": "1995",
"authors": "Taske NL, Eyre HJ, O'Brien RO, Sutherland GR, Denborough MA, Foster PS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "7588753",
"url": "https://glygen.org/publication/PubMed/7588753"
}
]
},
{
"title": "Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein.",
"journal": "Genomics",
"date": "1995",
"authors": "Borsani G, Rugarli EI, Taglialatela M, Wong C, Ballabio A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "7665160",
"url": "https://glygen.org/publication/PubMed/7665160"
}
]
},
{
"title": "Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.",
"journal": "Molecular and cellular biology",
"date": "1993",
"authors": "Fabian JR, Daar IO, Morrison DK",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "7692235",
"url": "https://glygen.org/publication/PubMed/7692235"
}
]
},
{
"title": "Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate.",
"journal": "Science (New York, N.Y.)",
"date": "1993",
"authors": "Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "7694366",
"url": "https://glygen.org/publication/PubMed/7694366"
}
]
},
{
"title": "B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.",
"journal": "Oncogene",
"date": "1995",
"authors": "Papin C, Eychene A, Brunet A, Pages G, Pouyssegur J, Calothy G, Barnier JV",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "7731720",
"url": "https://glygen.org/publication/PubMed/7731720"
}
]
},
{
"title": "Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Yamamori B, Kuroda S, Shimizu K, Fukui K, Ohtsuka T, Takai Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "7744815",
"url": "https://glygen.org/publication/PubMed/7744815"
}
]
},
{
"title": "Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface.",
"journal": "Biochemistry",
"date": "1995",
"authors": "Emerson S D, Madison V S, Palermo R E, Waugh D S, Scheffler J E, Tsao K L, Kiefer S E, Liu S P, Fry D C",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "7766599",
"url": "https://glygen.org/publication/PubMed/7766599"
}
]
},
{
"title": "The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.",
"journal": "Nature",
"date": "1995",
"authors": "Nassar N, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "7791872",
"url": "https://glygen.org/publication/PubMed/7791872"
}
]
},
{
"title": "Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues.",
"journal": "Human molecular genetics",
"date": "1995",
"authors": "Cid LP, Montrose-Rafizadeh C, Smith DI, Guggino WB, Cutting GR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "7795595",
"url": "https://glygen.org/publication/PubMed/7795595"
}
]
},
{
"title": "Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Seger R, Seger D, Reszka AA, Munar ES, Eldar-Finkelman H, Dobrowolska G, Jensen AM, Campbell JS, Fischer EH, Krebs EG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "7929275",
"url": "https://glygen.org/publication/PubMed/7929275"
}
]
},
{
"title": "Mechanism of inhibition of Raf-1 by protein kinase A.",
"journal": "Molecular and cellular biology",
"date": "1994",
"authors": "Hafner S, Adler HS, Mischak H, Janosch P, Heidecker G, Wolfman A, Pippig S, Lohse M, Ueffing M, Kolch W",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "7935389",
"url": "https://glygen.org/publication/PubMed/7935389"
}
]
},
{
"title": "The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.",
"journal": "Molecular and cellular biology",
"date": "1994",
"authors": "Jaiswal RK, Moodie SA, Wolfman A, Landreth GE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "7935411",
"url": "https://glygen.org/publication/PubMed/7935411"
}
]
},
{
"title": "Activation of Raf-1 by 14-3-3 proteins.",
"journal": "Nature",
"date": "1994",
"authors": "Fantl WJ, Muslin AJ, Kikuchi A, Martin JA, MacNicol AM, Gross RW, Williams LT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "7935795",
"url": "https://glygen.org/publication/PubMed/7935795"
}
]
},
{
"title": "Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1).",
"journal": "FEBS letters",
"date": "1994",
"authors": "Brunet A, Pages G, Pouyssegur J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674499"
}
],
"reference": [
{
"type": "PubMed",
"id": "8013650",
"url": "https://glygen.org/publication/PubMed/8013650"
}
]
},
{
"title": "Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "8034572",
"url": "https://glygen.org/publication/PubMed/8034572"
}
]
},
{
"title": "Two highly homologous members of the ClC chloride channel family in both rat and human kidney.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1994",
"authors": "Kieferle S, Fong P, Bens M, Vandewalle A, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8041726",
"url": "https://glygen.org/publication/PubMed/8041726"
}
]
},
{
"title": "Cytoplasmic localization of the mitogen-activated protein kinase activator MEK.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Zheng CF, Guan KL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "8051079",
"url": "https://glygen.org/publication/PubMed/8051079"
}
]
},
{
"title": "Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).",
"journal": "The EMBO journal",
"date": "1994",
"authors": "Steinmeyer K, Lorenz C, Pusch M, Koch MC, Jentsch TJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8112288",
"url": "https://glygen.org/publication/PubMed/8112288"
}
]
},
{
"title": "Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.",
"journal": "The EMBO journal",
"date": "1994",
"authors": "Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "8157000",
"url": "https://glygen.org/publication/PubMed/8157000"
}
]
},
{
"title": "RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.",
"journal": "The EMBO journal",
"date": "1993",
"authors": "Cook SJ, Rubinfeld B, Albert I, McCormick F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "8253074",
"url": "https://glygen.org/publication/PubMed/8253074"
}
]
},
{
"title": "Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Carroll MP, May WS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "8288587",
"url": "https://glygen.org/publication/PubMed/8288587"
}
]
},
{
"title": "Protein kinase C alpha activates RAF-1 by direct phosphorylation.",
"journal": "Nature",
"date": "1993",
"authors": "Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, Rapp UR",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "8321321",
"url": "https://glygen.org/publication/PubMed/8321321"
}
]
},
{
"title": "Identification of the major phosphorylation sites of the Raf-1 kinase.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Morrison DK, Heidecker G, Rapp UR, Copeland TD",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
}
]
},
{
"title": "Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Taglicht D, Padan E, Schuldiner S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8383669",
"url": "https://glygen.org/publication/PubMed/8383669"
}
]
},
{
"title": "KSR, a novel protein kinase required for RAS signal transduction.",
"journal": "Cell",
"date": "1995",
"authors": "Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "8521512",
"url": "https://glygen.org/publication/PubMed/8521512"
}
]
},
{
"title": "The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.",
"journal": "Cell",
"date": "1995",
"authors": "Sundaram M, Han M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "8521513",
"url": "https://glygen.org/publication/PubMed/8521513"
}
]
},
{
"title": "The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.",
"journal": "Cell",
"date": "1995",
"authors": "Kornfeld K, Hom DB, Horvitz HR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "8521514",
"url": "https://glygen.org/publication/PubMed/8521514"
}
]
},
{
"title": "Spectrum of mutations in the major human skeletal muscle chloride channel gene (CLCN1) leading to myotonia.",
"journal": "American journal of human genetics",
"date": "1995",
"authors": "Meyer-Kleine C, Steinmeyer K, Ricker K, Jentsch TJ, Koch MC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8533761",
"url": "https://glygen.org/publication/PubMed/8533761"
}
]
},
{
"title": "Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.",
"journal": "Kidney international",
"date": "1995",
"authors": "Takeuchi Y, Uchida S, Marumo F, Sasaki S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8544406",
"url": "https://glygen.org/publication/PubMed/8544406"
}
]
},
{
"title": "Interactions between Ras and Raf: key regulatory proteins in cellular transformation.",
"journal": "Molecular reproduction and development",
"date": "1995-12",
"authors": "Marshall M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "8607981",
"url": "https://glygen.org/publication/PubMed/8607981"
}
]
},
{
"title": "Cloning and expression of a novel human brain Na+ channel.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Price MP, Snyder PM, Welsh MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8626462",
"url": "https://glygen.org/publication/PubMed/8626462"
}
]
},
{
"title": "Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Du X, Fox JE, Pei S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "8631758",
"url": "https://glygen.org/publication/PubMed/8631758"
}
]
},
{
"title": "Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1.",
"journal": "Oncogene",
"date": "1996",
"authors": "Rommel C, Radziwill G, Lovric J, Noeldeke J, Heinicke T, Jones D, Aitken A, Moelling K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "8637718",
"url": "https://glygen.org/publication/PubMed/8637718"
}
]
},
{
"title": "The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.",
"journal": "Proc. Natl. Acad. Sci. U.S.A.",
"date": "1996",
"authors": "Mott H R, Carpenter J W, Zhong S, Ghosh S, Bell R M, Campbell S L",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "8710867",
"url": "https://glygen.org/publication/PubMed/8710867"
}
]
},
{
"title": "Ras/Rap effector specificity determined by charge reversal.",
"journal": "Nat. Struct. Biol.",
"date": "1996",
"authors": "Nassar N, Horn G, Herrmann C, Block C, Janknecht R, Wittinghofer A",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "8756332",
"url": "https://glygen.org/publication/PubMed/8756332"
}
]
},
{
"title": "The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis.",
"journal": "The Biochemical journal",
"date": "1996",
"authors": "Tunwell RE, Wickenden C, Bertrand BM, Shevchenko VI, Walsh MB, Allen PD, Lai FA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "8809036",
"url": "https://glygen.org/publication/PubMed/8809036"
}
]
},
{
"title": "The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1996",
"authors": "Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "8876196",
"url": "https://glygen.org/publication/PubMed/8876196"
}
]
},
{
"title": "KSR modulates signal propagation within the MAPK cascade.",
"journal": "Genes & development",
"date": "1996",
"authors": "Therrien M, Michaud NR, Rubin GM, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "8946910",
"url": "https://glygen.org/publication/PubMed/8946910"
}
]
},
{
"title": "Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.",
"journal": "Molecular and cellular biology",
"date": "1997",
"authors": "Yee WM, Worley PF",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "9001246",
"url": "https://glygen.org/publication/PubMed/9001246"
}
]
},
{
"title": "Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "9020159",
"url": "https://glygen.org/publication/PubMed/9020159"
}
]
},
{
"title": "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1997",
"authors": "Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9037075",
"url": "https://glygen.org/publication/PubMed/9037075"
}
]
},
{
"title": "Identification of Raf-1 Ser621 kinase activity from NIH 3T3 cells as AMP-activated protein kinase.",
"journal": "FEBS letters",
"date": "1997",
"authors": "Sprenkle AB, Davies SP, Carling D, Hardie DG, Sturgill TW",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "9091312",
"url": "https://glygen.org/publication/PubMed/9091312"
}
]
},
{
"title": "Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Hu CD, Kariya Ki, Kotani G, Shirouzu M, Yokoyama S, Kataoka T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "9115221",
"url": "https://glygen.org/publication/PubMed/9115221"
}
]
},
{
"title": "Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling.",
"journal": "Molecular and cellular biology",
"date": "1997",
"authors": "Diaz B, Barnard D, Filson A, MacDonald S, King A, Marshall M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "9234708",
"url": "https://glygen.org/publication/PubMed/9234708"
}
]
},
{
"title": "cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways.",
"journal": "Journal of neuroscience research",
"date": "1997",
"authors": "Kim HA, DeClue JE, Ratner N",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "9272646",
"url": "https://glygen.org/publication/PubMed/9272646"
}
]
},
{
"title": "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "9346962",
"url": "https://glygen.org/publication/PubMed/9346962"
}
]
},
{
"title": "14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Dubois T, Rommel C, Howell S, Steinhussen U, Soneji Y, Morrice N, Moelling K, Aitken A",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "9360956",
"url": "https://glygen.org/publication/PubMed/9360956"
}
]
},
{
"title": "Molecular cloning and characterization of a human brain ryanodine receptor.",
"journal": "FEBS letters",
"date": "1997",
"authors": "Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9395096",
"url": "https://glygen.org/publication/PubMed/9395096"
}
]
},
{
"title": "Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex.",
"journal": "Biochemistry",
"date": "1998",
"authors": "Andrews RK, Harris SJ, McNally T, Berndt MC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-430116",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116"
}
],
"reference": [
{
"type": "PubMed",
"id": "9425086",
"url": "https://glygen.org/publication/PubMed/9425086"
}
]
},
{
"title": "Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent.",
"journal": "The Journal of biological chemistry",
"date": "1998-01-30",
"authors": "Sakatsume M, Stancato L F, David M, Silvennoinen O, Saharinen P, Pierce J, Larner A C, Finbloom D S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9732724",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9732724"
}
],
"reference": [
{
"type": "PubMed",
"id": "9446616",
"url": "https://glygen.org/publication/PubMed/9446616"
}
]
},
{
"title": "Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis.",
"journal": "Biochemical and biophysical research communications",
"date": "1998",
"authors": "Ishibashi K, Marumo F",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9571199",
"url": "https://glygen.org/publication/PubMed/9571199"
}
]
},
{
"title": "Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300.",
"journal": "Molecular cell",
"date": "1998",
"authors": "Zhong H, Voll RE, Ghosh S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5621575",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575"
}
],
"reference": [
{
"type": "PubMed",
"id": "9660950",
"url": "https://glygen.org/publication/PubMed/9660950"
}
]
},
{
"title": "Identification of the gene responsible for Best macular dystrophy.",
"journal": "Nature genetics",
"date": "1998",
"authors": "Petrukhin K, Koisti MJ, Bakall B, Li W, Xie G, Marknell T, Sandgren O, Forsman K, Holmgren G, Andreasson S, Vujic M, Bergen AA, McGarty-Dugan V, Figueroa D, Austin CP, Metzker ML, Caskey CT, Wadelius C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9662395",
"url": "https://glygen.org/publication/PubMed/9662395"
}
]
},
{
"title": "Autoregulation of the Raf-1 serine/threonine kinase.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1998",
"authors": "Cutler RE Jr, Stephens RM, Saracino MR, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "9689060",
"url": "https://glygen.org/publication/PubMed/9689060"
}
]
},
{
"title": "Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease).",
"journal": "Human molecular genetics",
"date": "1998",
"authors": "Marquardt A, Stohr H, Passmore LA, Kramer F, Rivera A, Weber BH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9700209",
"url": "https://glygen.org/publication/PubMed/9700209"
}
]
},
{
"title": "14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.",
"journal": "Molecular and cellular biology",
"date": "1998",
"authors": "Thorson JA, Yu LW, Hsu AL, Shih NY, Graves PR, Tanner JW, Allen PM, Piwnica-Worms H, Shaw AS",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "9710607",
"url": "https://glygen.org/publication/PubMed/9710607"
}
]
},
{
"title": "Amiloride-sensitive Na channels.",
"journal": "Current opinion in cell biology",
"date": "1998",
"authors": "Horisberger JD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9719863",
"url": "https://glygen.org/publication/PubMed/9719863"
}
]
},
{
"title": "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.",
"journal": "Science (New York, N.Y.)",
"date": "1998",
"authors": "Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5674135",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135"
}
],
"reference": [
{
"type": "PubMed",
"id": "9733512",
"url": "https://glygen.org/publication/PubMed/9733512"
}
]
},
{
"title": "Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel.",
"journal": "FEBS letters",
"date": "1998",
"authors": "de Weille JR, Bassilana F, Lazdunski M, Waldmann R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-2672351",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351"
}
],
"reference": [
{
"type": "PubMed",
"id": "9744806",
"url": "https://glygen.org/publication/PubMed/9744806"
}
]
},
{
"title": "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1998",
"authors": "Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-392517",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517"
}
],
"reference": [
{
"type": "PubMed",
"id": "9789079",
"url": "https://glygen.org/publication/PubMed/9789079"
}
]
},
{
"title": "Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms.",
"journal": "Oncogene",
"date": "1998",
"authors": "Barnard D, Diaz B, Clawson D, Marshall M",
"evidence": [
{
"database": "iPTMnet",
"id": "P04049",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049"
}
],
"reference": [
{
"type": "PubMed",
"id": "9794231",
"url": "https://glygen.org/publication/PubMed/9794231"
}
]
},
{
"title": "The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338.",
"journal": "Nature",
"date": "1998",
"authors": "King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, Marshall MS",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
},
{
"database": "iPTMnet",
"id": "P04049-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P04049-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
}
]
},
{
"title": "Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.",
"journal": "Molecular and cellular biology",
"date": "1999",
"authors": "Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-5673000",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000"
}
],
"reference": [
{
"type": "PubMed",
"id": "9858547",
"url": "https://glygen.org/publication/PubMed/9858547"
}
]
}
],
"pathway": [
{
"id": "hsa:5894",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5894",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-2672351",
"name": "Stimuli-sensing channels",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2672351",
"resource": "Reactome",
"description": "Stimuli-sensing channels"
},
{
"id": "R-HSA-392517",
"name": "Rap1 signalling",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392517",
"resource": "Reactome",
"description": "Rap1 signalling"
},
{
"id": "R-HSA-430116",
"name": "GP1b-IX-V activation signalling",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-430116",
"resource": "Reactome",
"description": "GP1b-IX-V activation signalling"
},
{
"id": "R-HSA-5621575",
"name": "CD209 (DC-SIGN) signaling",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575",
"resource": "Reactome",
"description": "CD209 (DC-SIGN) signaling"
},
{
"id": "R-HSA-5673000",
"name": "RAF activation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000",
"resource": "Reactome",
"description": "RAF activation"
},
{
"id": "R-HSA-5674135",
"name": "MAP2K and MAPK activation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135",
"resource": "Reactome",
"description": "MAP2K and MAPK activation"
},
{
"id": "R-HSA-5674499",
"name": "Negative feedback regulation of MAPK pathway",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674499",
"resource": "Reactome",
"description": "Negative feedback regulation of MAPK pathway"
},
{
"id": "R-HSA-5675221",
"name": "Negative regulation of MAPK pathway",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221",
"resource": "Reactome",
"description": "Negative regulation of MAPK pathway"
},
{
"id": "R-HSA-6802946",
"name": "Signaling by moderate kinase activity BRAF mutants",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946",
"resource": "Reactome",
"description": "Signaling by moderate kinase activity BRAF mutants"
},
{
"id": "R-HSA-6802948",
"name": "Signaling by high-kinase activity BRAF mutants",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948",
"resource": "Reactome",
"description": "Signaling by high-kinase activity BRAF mutants"
},
{
"id": "R-HSA-6802952",
"name": "Signaling by BRAF and RAF1 fusions",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952",
"resource": "Reactome",
"description": "Signaling by BRAF and RAF1 fusions"
},
{
"id": "R-HSA-6802955",
"name": "Paradoxical activation of RAF signaling by kinase inactive BRAF",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955",
"resource": "Reactome",
"description": "Paradoxical activation of RAF signaling by kinase inactive BRAF"
},
{
"id": "R-HSA-9649948",
"name": "Signaling downstream of RAS mutants",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948",
"resource": "Reactome",
"description": "Signaling downstream of RAS mutants"
},
{
"id": "R-HSA-9656223",
"name": "Signaling by RAF1 mutants",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223",
"resource": "Reactome",
"description": "Signaling by RAF1 mutants"
},
{
"id": "R-HSA-9726840",
"name": "SHOC2 M1731 mutant abolishes MRAS complex function",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726840",
"resource": "Reactome",
"description": "SHOC2 M1731 mutant abolishes MRAS complex function"
},
{
"id": "R-HSA-9726842",
"name": "Gain-of-function MRAS complexes activate RAF signaling",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9726842",
"resource": "Reactome",
"description": "Gain-of-function MRAS complexes activate RAF signaling"
},
{
"id": "R-HSA-9732724",
"name": "IFNG signaling activates MAPKs",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9732724",
"resource": "Reactome",
"description": "IFNG signaling activates MAPKs"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "P11345-1",
"protein_name": "RAF proto-oncogene serine/threonine-protein kinase",
"gene_name": "Raf1",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTASDSGVPAPPSFTMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 648
},
"evidence": [
{
"id": "45917798",
"url": "http://www.informatics.jax.org/homology/45917798",
"database": "MGI"
}
],
"common_name": "Rat"
},
{
"uniprot_canonical_ac": "Q99N57-1",
"protein_name": "RAF proto-oncogene serine/threonine-protein kinase",
"gene_name": "Raf1",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF",
"length": 648
},
"evidence": [
{
"id": "45917798",
"url": "http://www.informatics.jax.org/homology/45917798",
"database": "MGI"
},
{
"id": "P04049",
"url": "https://omabrowser.org/oma/group/P04049/",
"database": "OMA"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Biological Process",
"total": 41,
"go_terms": [
{
"name": "protein modification process",
"id": "GO:0036211",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "positive regulation of protein phosphorylation",
"id": "GO:0001934",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "signal transduction",
"id": "GO:0007165",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "negative regulation of apoptotic process",
"id": "GO:0043066",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "regulation of intracellular signal transduction",
"id": "GO:1902531",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902531",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "positive regulation of macromolecule metabolic process",
"id": "GO:0010604",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010604",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "positive regulation of nitrogen compound metabolic process",
"id": "GO:0051173",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051173",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "regulation of protein modification process",
"id": "GO:0031399",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031399",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "thyroid gland development",
"id": "GO:0030878",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030878",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "protein phosphorylation",
"id": "GO:0006468",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "activation of adenylate cyclase activity",
"id": "GO:0007190",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007190",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "negative regulation of cell population proliferation",
"id": "GO:0008285",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "positive regulation of peptidyl-serine phosphorylation",
"id": "GO:0033138",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033138",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "positive regulation of MAPK cascade",
"id": "GO:0043410",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "positive regulation of transcription by RNA polymerase II",
"id": "GO:0045944",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "regulation of cell motility",
"id": "GO:2000145",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000145",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "MAPK cascade",
"id": "GO:0000165",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "apoptotic process",
"id": "GO:0006915",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "myelination",
"id": "GO:0042552",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "negative regulation of cysteine-type endopeptidase activity involved in apoptotic process",
"id": "GO:0043154",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043154",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "type II interferon-mediated signaling pathway",
"id": "GO:0060333",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060333",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "regulation of Rho protein signal transduction",
"id": "GO:0035023",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "thymus development",
"id": "GO:0048538",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048538",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "face development",
"id": "GO:0060324",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060324",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "insulin receptor signaling pathway",
"id": "GO:0008286",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "negative regulation of protein-containing complex assembly",
"id": "GO:0031333",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031333",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "regulation of apoptotic process",
"id": "GO:0042981",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "regulation of cell differentiation",
"id": "GO:0045595",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045595",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "response to muscle stretch",
"id": "GO:0035994",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035994",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "neurotrophin TRK receptor signaling pathway",
"id": "GO:0048011",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048011",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "insulin-like growth factor receptor signaling pathway",
"id": "GO:0048009",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048009",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors",
"id": "GO:1902042",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902042",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "wound healing",
"id": "GO:0042060",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "somatic stem cell population maintenance",
"id": "GO:0035019",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035019",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "extrinsic apoptotic signaling pathway via death domain receptors",
"id": "GO:0008625",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008625",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "death-inducing signaling complex assembly",
"id": "GO:0071550",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071550",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "intermediate filament cytoskeleton organization",
"id": "GO:0045104",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045104",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "Schwann cell development",
"id": "GO:0014044",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014044",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "type B pancreatic cell proliferation",
"id": "GO:0044342",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044342",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "ERBB2-ERBB3 signaling pathway",
"id": "GO:0038133",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038133",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "insulin secretion involved in cellular response to glucose stimulus",
"id": "GO:0035773",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035773",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 8,
"go_terms": [
{
"name": "protein kinase activity",
"id": "GO:0004672",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "ATP binding",
"id": "GO:0005524",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "metal ion binding",
"id": "GO:0046872",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "protein serine/threonine kinase activity",
"id": "GO:0004674",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "enzyme binding",
"id": "GO:0019899",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "identical protein binding",
"id": "GO:0042802",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "MAP kinase kinase kinase activity",
"id": "GO:0004709",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004709",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "protein serine kinase activity",
"id": "GO:0106310",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106310",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 8,
"go_terms": [
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "mitochondrion",
"id": "GO:0005739",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "mitochondrial outer membrane",
"id": "GO:0005741",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "Golgi apparatus",
"id": "GO:0005794",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
},
{
"name": "pseudopodium",
"id": "GO:0031143",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031143",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 198,
"end_pos": 200,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 241,
"end_pos": 243,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 299,
"end_pos": 301,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 617,
"end_pos": 619,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Methylated at Arg-563 in response to EGF treatment. This modification leads to destabilization of the protein, possibly through proteasomal degradation.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
}
]
},
{
"annotation": "Phosphorylation at Thr-269, Ser-338, Tyr-341, Thr-491 and Ser-494 results in its activation. Phosphorylation at Ser-29, Ser-43, Ser-289, Ser-296, Ser-301 and Ser-642 by MAPK1/ERK2 results in its inactivation. Phosphorylation at Ser-259 induces the interaction with YWHAZ and inactivates kinase activity. Dephosphorylation of Ser-259 by the complex containing protein phosphatase 1, SHOC2 and M-Ras/MRAS relieves inactivation, leading to stimulate RAF1 activity. Phosphorylation at Ser-338 by PAK1 and PAK5 and Ser-339 by PAK1 is required for its mitochondrial localization. Phosphorylation at Ser-621 in response to growth factor treatment stabilizes the protein, possibly by preventing proteasomal degradation. Phosphorylation at Ser-289, Ser-296, Ser-301, Ser-338 and Ser-621 are somehow linked to the methylation potential of cells. Treatment of cells with HGF in the presence of the methylation inhibitor 5'-methylthioadenosine (MTA) results in increased phosphorylation at Ser-338 and Ser-621 and decreased phosphorylation at Ser-296, Ser-301 and Ser-338. Dephosphorylation at Ser-338 by PPP5C results in an activity decrease.",
"evidence": [
{
"database": "UniProtKB",
"id": "P04049",
"url": "https://www.uniprot.org/uniprot/P04049"
},
{
"database": "PubMed",
"id": "7477354",
"url": "https://glygen.org/publication/PubMed/7477354"
},
{
"database": "PubMed",
"id": "11447113",
"url": "https://glygen.org/publication/PubMed/11447113"
},
{
"database": "PubMed",
"id": "16630891",
"url": "https://glygen.org/publication/PubMed/16630891"
},
{
"database": "PubMed",
"id": "18465753",
"url": "https://glygen.org/publication/PubMed/18465753"
},
{
"database": "PubMed",
"id": "21917714",
"url": "https://glygen.org/publication/PubMed/21917714"
},
{
"database": "PubMed",
"id": "10576742",
"url": "https://glygen.org/publication/PubMed/10576742"
},
{
"database": "PubMed",
"id": "16892053",
"url": "https://glygen.org/publication/PubMed/16892053"
},
{
"database": "PubMed",
"id": "9823899",
"url": "https://glygen.org/publication/PubMed/9823899"
},
{
"database": "PubMed",
"id": "8349614",
"url": "https://glygen.org/publication/PubMed/8349614"
},
{
"database": "PubMed",
"id": "16093354",
"url": "https://glygen.org/publication/PubMed/16093354"
},
{
"database": "PubMed",
"id": "11756411",
"url": "https://glygen.org/publication/PubMed/11756411"
},
{
"database": "PubMed",
"id": "15849194",
"url": "https://glygen.org/publication/PubMed/15849194"
},
{
"database": "PubMed",
"id": "11733498",
"url": "https://glygen.org/publication/PubMed/11733498"
},
{
"database": "PubMed",
"id": "10801873",
"url": "https://glygen.org/publication/PubMed/10801873"
},
{
"database": "PubMed",
"id": "15047712",
"url": "https://glygen.org/publication/PubMed/15047712"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "17989",
"name": "",
"equation": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"B2DD29-1",
"D3ZML2-1",
"O08875-1",
"O35831-1",
"D3ZHP7-1",
"D4A280-1",
"E9PTG8-1",
"O35832-1",
"O54748-1",
"P57760-1",
"Q62868-1",
"D3ZBE5-1",
"P59895-1",
"O55099-1",
"O88764-1",
"P59241-1",
"Q91XS8-1",
"Q63644-1",
"Q7TQP6-1",
"Q9Z2P5-1",
"P11345-1",
"P11275-1",
"F1LYY7-1",
"Q9JIH7-1",
"P14056-1",
"P35426-1",
"P51952-1",
"P63086-1",
"Q5U2X5-1",
"Q5XIT0-1",
"Q63117-1",
"F1M7Y5-1",
"P47196-1",
"P47197-1",
"P97874-1",
"Q03114-1",
"Q3MJK5-1",
"Q09137-1",
"Q4V8A3-1",
"P54645-1",
"Q63686-1",
"P08413-1",
"P0C1X8-1",
"P19139-1",
"D4A7V9-1",
"Q63184-1",
"Q63484-1",
"Q9Z1Z1-1",
"Q4KM34-1",
"Q4KM47-1",
"O08874-1",
"O70444-1",
"O88831-1",
"P0C0R5-1",
"P26794-1",
"P46892-1",
"Q66HE7-1",
"Q6XUX2-1",
"Q62915-1",
"Q63185-1",
"Q63470-1",
"Q62673-1",
"Q63433-1",
"P53669-1",
"P53670-1",
"Q63699-1",
"Q641Z4-1",
"Q91ZN7-1",
"A0A0G2K344-1",
"P18265-1",
"P39951-1",
"B2GUY1-1",
"B0LT89-1",
"A1A5Q6-1",
"F1LP90-1",
"O08815-1",
"O88850-1",
"P00539-1",
"P0C865-1",
"P27791-1",
"P63319-1",
"P68182-1",
"P97924-1",
"Q01986-1",
"Q06226-1",
"Q53UA7-1",
"Q62862-1",
"Q63454-1",
"Q63531-1",
"Q63562-1",
"Q63572-1",
"Q64617-1",
"Q66HA1-1",
"Q7TNL4-1",
"P09215-1",
"O55173-1",
"O70150-1",
"P05696-1",
"P09216-1",
"P11730-1",
"P13234-1",
"P15791-1",
"P68403-1",
"P97633-1",
"P97756-1",
"Q62761-1",
"Q62762-1",
"Q62763-1",
"B1WBU5-1",
"D3ZGQ5-1",
"D4AE59-1",
"F1M0Z1-1",
"P13286-1",
"P49187-1",
"Q5RKH1-1",
"Q62829-1",
"Q63638-1",
"Q9JLS3-1",
"Q9JM01-1",
"Q9R011-1",
"Q9R012-1",
"D3ZSZ3-1",
"Q06486-1",
"Q62726-1",
"Q63450-1",
"Q4KSH7-1",
"Q5XIS9-1",
"Q63285-1",
"Q63553-1",
"P67999-1",
"O88664-1",
"O08678-1",
"O08679-1",
"Q99J82-1",
"Q7TNJ7-1",
"Q64303-1",
"Q66HE5-1",
"Q7TPK6-1",
"Q64595-1",
"P49185-1",
"P09217-1",
"P36506-1",
"P35465-1",
"P20793-1",
"O88506-1",
"Q9Z335-1",
"Q8R4U9-1",
"Q8R4V0-1",
"Q924U5-1",
"Q9WTQ1-1",
"Q9Z2A6-1",
"D3ZG83-1",
"P21708-1",
"P27704-1",
"Q4V793-1",
"Q5MPA9-1",
"Q5U2N4-1",
"Q62925-1",
"Q63538-1",
"Q66H84-1",
"Q9WTY9-1",
"O54874-1",
"Q8VHF0-1",
"P42346-1",
"P49186-1",
"Q4G050-1",
"P70618-1",
"Q925B3-1",
"Q63796-1",
"Q7TT49-1",
"Q810W7-1",
"Q924I2-1",
"Q9R1U5-1",
"Q9WTQ0-1",
"P0C8E4-1",
"P18266-1",
"D4AE24-1",
"D3ZSB7-1",
"A4L9P5-1",
"D4A6T9-1",
"E9PSL7-1",
"F1LXF1-1",
"D3Z822-1",
"A0A8I6AQN6-1",
"D3Z8E0-1",
"F1M7N7-1",
"A0A8I6AWX7-1",
"Q9QY78-1",
"E9PSK5-1",
"A0A0G2JZW9-1",
"A0A0G2KB60-1",
"D3ZHL6-1",
"Q63945-1",
"F1LNN8-1",
"A0A0G2K5L3-1",
"F7FMK8-1",
"A0A8I5ZMP0-1",
"M0RD40-1",
"A0A0G2JVL3-1",
"F1LRA7-1",
"A0A8I5ZP97-1",
"D3Z837-1",
"D3ZL21-1",
"A0A8I6AUJ4-1",
"F1M7G0-1",
"D4A355-1",
"D4A454-1",
"D3ZCD7-1",
"D3ZFL3-1",
"D3ZXB1-1",
"A0A8I5ZZZ6-1",
"A0A0G2JUP3-1",
"D3Z8I4-1",
"A0A8I5ZNK2-1",
"D3ZRJ7-1",
"D4AD76-1",
"F1M419-1",
"A0A8I6ANX6-1",
"A0A8I6A165-1",
"B5DFG1-1",
"A0A8I6A0F8-1",
"F1LNJ1-1",
"A0A8I6AEL0-1",
"A0A8I6ATH0-1",
"D3ZTD1-1",
"M0RBT0-1",
"A0A8I5Y8C3-1",
"A0A8I6GK52-1",
"D4A6T6-1",
"A0A8I6ATM1-1",
"A0A8I6G1H3-1",
"D3ZMG0-1",
"F1LUY7-1",
"A0A8I6A7D1-1",
"A0A8J8XEH6-1",
"A0A8I6AD01-1",
"A0A8I6AJX5-1",
"A6KB61-1",
"Q9Z1L0-1",
"G3V783-1",
"Q6V9V9-1",
"A0A8I5ZUS1-1",
"A0A0G2K578-1",
"A0A0G2K6V9-1",
"D4A9H8-1",
"D3ZJ84-1",
"A0A8I5ZV60-1",
"B1WBT4-1",
"A0A8I6A574-1",
"Q4KLN3-1",
"A0A8I6AHQ6-1",
"A0A0G2K5C7-1",
"M0RDM0-1",
"Q6V9Y3-1",
"M0R777-1",
"D3ZDM6-1",
"D3ZD18-1",
"Q5PQT0-1",
"Q6V9Y2-1",
"D3ZQN8-1",
"F1LWF2-1",
"F1M9D0-1",
"A0A8I5ZUX6-1",
"A0A8I5ZT61-1",
"A0A8I5ZN46-1",
"A0A8I5Y7S3-1",
"A0A0G2K2T8-1",
"A0A0G2JWX7-1",
"A0A0G2JXR8-1",
"D3ZSY9-1",
"D4A3H8-1",
"D4A3D9-1",
"D3ZZK7-1",
"A0A8I5ZLV4-1",
"A0A0G2KAH6-1",
"A0A0G2QC55-1",
"A0A8I5ZR62-1",
"A0A8I6A1U5-1",
"A0A8I6A8U4-1",
"A0A8I6A9X0-1",
"A0A8I6ACE8-1",
"D3ZBS8-1",
"A0A8I6GI15-1",
"D3ZEK4-1",
"A0A8I6GM03-1",
"Q4KSH6-1",
"F1LWJ6-1",
"F1LTP9-1",
"E9PSM2-1",
"M0RD88-1",
"D4A949-1",
"A0A8I6A7V5-1",
"A0A8I5ZSS7-1",
"A0A8I6GBQ0-1",
"A0A8I6AAX5-1",
"A0A8I6ACR1-1",
"A0A8I6GDY5-1",
"A0A8I6GJV1-1",
"A0A8I6G980-1",
"A0A8I5ZS27-1",
"A0A8I5ZYM4-1",
"A6HK01-1",
"A0A0G2K490-1",
"M0R7E7-1",
"A0A8I6AJD2-1",
"A0A8I6GK16-1",
"A0A8I6GKS8-1",
"A0A8I6G5Z0-1",
"Q925D6-1",
"Q00972-1",
"A0A8I5ZKJ9-1",
"Q9HCP0-1",
"P0C263-1",
"Q6ZMQ8-1",
"Q2M2I8-1",
"P31751-1",
"Q07912-1",
"Q5VT25-1",
"O43293-1",
"P53779-1",
"Q9P0L2-1",
"Q13164-1",
"P21127-1",
"Q9BWU1-1",
"Q9UQ88-1",
"Q00537-1",
"Q8IZL9-1",
"Q9UQB9-1",
"Q8IWQ3-1",
"Q9NYV4-1",
"Q13315-1",
"Q96GD4-1",
"P06493-1",
"Q00526-1",
"O60566-1",
"O76039-2",
"O94921-1",
"Q00535-1",
"Q8IVW4-1",
"Q9Y243-1",
"Q07002-2",
"P50613-1",
"Q92772-1",
"P10398-1",
"Q8NFD2-1",
"O43683-1",
"O14965-1",
"P24941-1",
"Q15131-1",
"Q9NSY1-1",
"P33076-1",
"Q86TB3-1",
"P50750-1",
"Q14004-1",
"P11802-1",
"Q8TDC3-1",
"O00311-1",
"Q00536-1",
"P11274-1",
"P49336-1",
"Q96QP1-1",
"Q96L96-1",
"Q13131-1",
"P31749-1",
"Q13535-1",
"P54646-1",
"O96017-1",
"P49760-1",
"Q5MAI5-1",
"Q00532-1",
"Q00534-1",
"P49761-4",
"Q9HAZ1-1",
"P49759-1",
"Q96Q40-1",
"P41279-1",
"P15056-1",
"O14757-1",
"P68400-1",
"Q6XUX3-1",
"Q9Y463-1",
"Q76MJ5-1",
"Q9P2K8-1",
"P19525-1",
"Q8N568-1",
"Q09013-9",
"Q9NR20-1",
"Q9NZJ5-1",
"O15075-1",
"Q9C098-1",
"O14578-1",
"P53355-1",
"O14936-1",
"Q8IXL6-1",
"Q13627-1",
"Q9Y4B6-1",
"Q9BQI3-1",
"Q9UIK4-1",
"Q92630-1",
"Q8NEV1-1",
"O43781-1",
"O75460-1",
"P19784-1",
"Q13557-1",
"Q13976-1",
"P17252-1",
"P41743-1",
"Q15418-1",
"P51617-1",
"Q15349-1",
"Q9UQM7-1",
"Q13554-1",
"Q9NRM7-1",
"O95835-1",
"Q9H2X6-1",
"P49674-1",
"Q86Z02-1",
"Q16566-1",
"Q6P2M8-1",
"P78368-1",
"Q96NX5-1",
"Q9Y6M4-1",
"P22612-1",
"P57058-1",
"Q9H422-1",
"Q9NWZ3-1",
"Q8IWU2-1",
"Q8N5S9-1",
"O14976-1",
"Q8NE63-1",
"Q13555-1",
"Q96RR4-1",
"Q15139-1",
"P11801-1",
"O94806-1",
"Q13237-1",
"Q96S38-1",
"Q9UK32-1",
"Q8N752-1",
"Q14012-1",
"P05129-1",
"Q9UBS0-1",
"O60229-1",
"P51812-1",
"P05771-1",
"Q05655-1",
"Q02156-1",
"P53667-1",
"Q9UPZ9-1",
"Q13418-1",
"P23443-1",
"Q8TF76-1",
"Q04759-1",
"Q9BZL6-1",
"Q05513-1",
"Q6VAB6-1",
"P49840-1",
"P49841-1",
"P48730-1",
"O75676-1",
"O75582-1",
"P24723-1",
"Q8IVT5-1",
"Q8IU85-1",
"Q96GX5-1",
"P22694-1",
"P48729-1",
"P17612-1",
"Q16659-1",
"Q02750-1",
"O14733-1",
"Q8TD08-1",
"Q9Y2U5-1",
"Q6P0Q8-1",
"P46734-1",
"P51957-1",
"Q6DT37-1",
"Q5VST9-1",
"Q9Y5S2-1",
"Q9UQ07-1",
"P28482-1",
"P00540-1",
"O75914-1",
"Q99759-1",
"Q99558-1",
"P51955-1",
"Q8IW41-1",
"Q9Y6R4-1",
"P51956-1",
"Q6P3R8-1",
"Q13163-1",
"Q13233-1",
"O60307-1",
"Q56UN5-1",
"O95382-1",
"Q02779-1",
"O15021-5",
"P45985-1",
"Q86SG6-1",
"Q6ZWH5-1",
"Q86YV6-1",
"Q8WXR4-1",
"Q8NEV4-1",
"Q6A1A2-1",
"P80192-1",
"P31152-1",
"O15264-1",
"P52564-1",
"Q96QS6-1",
"O60285-1",
"Q7Z2Y5-1",
"Q15759-1",
"P49137-1",
"Q16644-1",
"Q96L34-1",
"P53778-1",
"Q9UBE8-1",
"O95819-1",
"Q8N4C8-1",
"P36507-1",
"Q96Q04-1",
"P53671-1",
"Q8NG66-1",
"Q9Y4K4-1",
"Q9HBH9-1",
"Q96PY6-1",
"Q9H093-1",
"O43318-1",
"Q16584-1",
"Q7KZI7-1",
"Q9BUB5-1",
"Q8IY84-1",
"P45984-1",
"Q99683-1",
"O43283-1",
"Q12852-1",
"Q16539-1",
"Q38SD2-1",
"Q92918-1",
"Q9Y2H9-1",
"Q8TD19-1",
"Q5TCX8-1",
"Q9NYL2-1",
"P20794-1",
"Q8IVH8-1",
"Q12851-1",
"Q14680-1",
"P45983-1",
"Q13153-1",
"Q5S007-1",
"Q6ZN16-1",
"P42345-1",
"P27448-5",
"P27361-1",
"Q9NYY3-1",
"Q96RG2-1",
"Q9Y6S9-1",
"Q15772-5",
"Q16816-1",
"Q16513-1",
"Q99570-1",
"Q86V86-1",
"Q16512-1",
"P57059-1",
"Q9BXM7-1",
"Q13464-1",
"Q9P286-1",
"Q8N165-1",
"Q99640-1",
"P57078-1",
"O14730-1",
"O96013-1",
"Q9H4B4-1",
"O43930-1",
"Q13523-1",
"Q9HBY8-2",
"O75116-1",
"Q52WX2-1",
"O00141-1",
"P0C264-1",
"Q96BR1-1",
"Q9P1W9-1",
"Q6P5Z2-1",
"Q96LW2-1",
"O15530-1",
"Q9NQU5-1",
"Q13177-1",
"Q9BRS2-1",
"P48736-1",
"P11309-1",
"Q13546-1",
"Q9NRH2-1",
"Q9H0K1-1",
"P42336-1",
"P51817-1",
"P04049-1",
"O00444-1",
"P78527-1",
"Q96Q15-1",
"Q96S44-1",
"Q9Y572-1",
"Q9BVS4-1",
"O43353-1",
"P53350-1",
"O95747-1",
"O00506-1",
"Q15208-1",
"Q8N2I9-1",
"Q9BXU1-1",
"Q9BYT3-1",
"Q9UEE5-1",
"Q9UEW8-1",
"O94768-1",
"Q8TDR2-1",
"Q9BX84-1",
"Q96QT4-1",
"Q96KB5-1",
"A0A0B4J2F2-1",
"Q9NRP7-1",
"P78362-1",
"Q9BXA7-1",
"O75385-1",
"Q5TCY1-1",
"Q9Y3S1-1",
"Q8WZ42-1",
"O75716-1",
"Q13188-1",
"Q13043-1",
"Q96PN8-1",
"Q9Y2H1-1",
"O75962-1",
"Q9UPE1-1",
"Q15569-1",
"Q8IYT8-1",
"Q6PHR2-1",
"Q96C45-1",
"Q9H2K8-1",
"Q9Y6E0-1",
"Q9H2G2-1",
"Q96S53-1",
"P21675-2",
"Q7L7X3-1",
"Q9UL54-1",
"Q9UKE5-1",
"Q96SB4-2",
"Q15831-1",
"Q96J92-1",
"Q9BXA6-1",
"Q96PF2-1",
"Q59H18-2",
"Q6SA08-1",
"Q6IQ55-1",
"Q8TAS1-1",
"P33981-1",
"Q99986-1",
"O94804-1",
"Q9P289-1",
"Q8WU08-1",
"Q9NY57-1",
"Q86UX6-1",
"Q9UKI8-1",
"Q86UE8-1",
"Q86Y07-1",
"Q9BYP7-1",
"Q9Y2K2-5",
"Q9H4A3-1",
"Q9UHD2-1",
"Q9HC98-1",
"Q8TDX7-1",
"Q9Y2I7-1",
"O14920-1",
"P42338-1",
"Q14296-1",
"O14874-1",
"Q5SYL1-1",
"E9Q3S4-1",
"Q62070-1",
"Q91Y86-1",
"Q9Z188-1",
"Q9JKK8-1",
"Q8R4K2-1",
"Q05512-1",
"Q66L42-1",
"Q9Z1B7-1",
"Q8C050-1",
"Q3UHJ0-1",
"Q7TT50-1",
"O70405-1",
"Q61831-1",
"Q99MQ3-1",
"P49025-1",
"Q03141-1",
"Q9Z0R0-1",
"Q69ZM6-1",
"Q9WVS8-1",
"Q9WVC6-1",
"P04627-1",
"Q60823-1",
"O54967-1",
"Q924C5-1",
"Q8BRK8-1",
"Q91ZB0-1",
"P31750-1",
"Q5EG47-1",
"O88445-1",
"Q5RJI5-1",
"Q9Z1S0-1",
"O08901-1",
"P49615-1",
"Q04899-1",
"Q3TZA2-1",
"Q8BLF2-1",
"Q8R3L8-1",
"Q9WUA6-1",
"P24788-1",
"O35495-1",
"Q14AX6-1",
"Q3UMM4-1",
"Q64261-1",
"Q8BWD8-1",
"Q3UTQ8-1",
"Q8CEQ0-1",
"Q03147-1",
"Q8K0D0-1",
"Q8BZ25-1",
"O35491-1",
"O35493-1",
"Q9Z265-1",
"Q69ZA1-1",
"Q80YP0-1",
"Q9JHU3-1",
"Q9QUK0-1",
"P11440-1",
"Q62388-1",
"Q91Z96-1",
"O35280-1",
"O35492-1",
"P28028-3",
"Q99J95-1",
"P30285-1",
"P97377-1",
"Q9Z0H0-1",
"O70126-1",
"O70589-1",
"P97477-1",
"P79621-1",
"Q04735-1",
"Q3V3A1-1",
"Q69Z98-1",
"Q6PAJ1-1",
"Q9CXB8-1",
"P22518-1",
"P54265-1",
"Q6XUX1-1",
"Q03963-1",
"O54833-1",
"Q80TR8-1",
"Q60737-1",
"Q80YE7-1",
"Q8BWQ5-1",
"Q9JLM8-1",
"Q6PGN3-1",
"Q99KY4-1",
"Q61214-1",
"Q8VDF3-1",
"Q922Y0-1",
"O54784-1",
"Q9EQY0-1",
"Q8BI55-1",
"Q9Z2E3-1",
"Q5U4C9-1",
"Q5MJS3-1",
"Q9Z2R9-1",
"Q9QZ05-1",
"Q9Z2B5-1",
"Q91YS8-1",
"P68404-1",
"Q91YA2-1",
"P68181-1",
"Q7TPS0-1",
"Q8BTH8-1",
"Q8C4X2-1",
"Q8K1Y2-1",
"P16054-1",
"P28867-1",
"O88904-1",
"Q9ERH7-1",
"Q3V016-1",
"Q8BVP5-1",
"Q8BW96-1",
"Q9QYK9-1",
"P08414-1",
"Q8C078-1",
"P53349-1",
"Q3U1V8-1",
"Q80XI6-1",
"Q80YE4-1",
"Q3TYD6-1",
"O08648-1",
"Q07174-1",
"Q1HKZ5-1",
"Q61083-1",
"Q3U214-1",
"Q8VBY2-1",
"P49138-1",
"Q02111-1",
"P53668-1",
"Q9Z2B9-1",
"P70218-1",
"Q62406-1",
"Q61084-1",
"O88866-1",
"Q61410-1",
"P20444-1",
"Q62074-1",
"Q9WUT3-1",
"P0C605-1",
"P23298-1",
"P63318-1",
"P18653-1",
"Q8BLK9-1",
"Q9WUL6-1",
"Q9Z1M4-1",
"Q8C0P0-1",
"P28652-1",
"Q8BZ03-1",
"Q60700-1",
"Q61161-1",
"Q923T9-1",
"Q91VB2-1",
"Q8VHJ5-1",
"Q9QZR5-1",
"O55222-1",
"Q9JMK2-1",
"O54785-1",
"O35099-1",
"O54992-1",
"Q5S006-1",
"P18654-1",
"Q8BSK8-1",
"Q8CIP4-1",
"Q811L6-1",
"Q8BPM2-1",
"Q62101-1",
"A2CG49-1",
"Q6PHZ2-1",
"Q62073-1",
"Q8BYR2-1",
"Q9R1L5-1",
"Q9WTR2-1",
"A2AQW0-1",
"Q8VDG6-1",
"P11798-1",
"Q02956-1",
"Q04859-1",
"Q99JP0-1",
"P97820-1",
"Q2NL51-1",
"Q61097-1",
"Q3UHC2-1",
"Q3UVC0-1",
"Q5XJV6-1",
"Q60592-1",
"Q7TSJ6-1",
"Q9DC28-1",
"Q9JKV2-1",
"Q9ESL4-1",
"Q8BK63-1",
"Q9WV60-1",
"P05132-1",
"P63085-1",
"P31938-1",
"Q9WVS7-1",
"P00536-1",
"Q3UMW7-1",
"Q61532-1",
"Q61846-1",
"Q6P5G0-1",
"Q1EG27-1",
"Q8K3H5-1",
"Q5SUV5-1",
"Q9Z2A0-1",
"Q8VD65-1",
"Q8C015-1",
"P47809-1",
"Q3UU96-1",
"P70236-1",
"Q91ZR4-1",
"Q7TSC3-1",
"Q9R0A5-1",
"Q641K5-1",
"Q9R0G8-1",
"Q3ULB5-1",
"Q61036-1",
"Q8BTW9-1",
"Q8CEE6-1",
"P58750-1",
"P06803-1",
"P53351-1",
"Q60806-1",
"Q8K045-1",
"P07934-1",
"P70268-1",
"O08911-1",
"Q63844-1",
"Q80Y86-1",
"Q9WUI1-1",
"O35942-1",
"Q8QZR7-1",
"Q8BWW9-1",
"Q8K1R7-1",
"Q63932-1",
"Q8BHI9-1",
"O09110-1",
"O54949-1",
"P42337-1",
"Q8CE90-1",
"Q8C0Q4-1",
"O08605-1",
"A2AAJ9-1",
"P47811-1",
"Q8CDB0-1",
"P51954-1",
"Q8CIN4-1",
"Q80UW5-1",
"Q8BZN4-1",
"Q9WVS4-1",
"Q9WTU6-1",
"Q9Z1J2-1",
"Q9JLN9-1",
"O88643-1",
"Q07832-1",
"Q3UGM2-1",
"Q9JHG7-1",
"Q9JM52-1",
"Q6P9R2-1",
"Q64702-1",
"Q61136-1",
"Q922R0-1",
"P70336-1",
"Q8R2S1-1",
"P0C5K0-1",
"P0C5K1-1",
"Q9Z0G2-1",
"Q8C0X8-1",
"Q9QYZ4-1",
"Q62407-1",
"Q8C0V7-1",
"O54988-1",
"Q9JJ78-1",
"Q3UVR3-1",
"Q9D2E1-1",
"Q6PCN3-1",
"Q9ESG9-1",
"A2KF29-1",
"Q8BKX6-1",
"A0AUV4-1",
"Q7TSE6-1",
"Q9JI10-1",
"Q0KL02-1",
"Q3U3Q1-1",
"Q3V129-1",
"Q9QY01-1",
"P70335-1",
"Q8CFH6-1",
"Q9WUN2-1",
"Q8QZX0-1",
"Q8C0N0-1",
"Q9ERE3-1",
"Q9QZS5-1",
"O88697-1",
"Q80ZW0-1",
"O55098-1",
"Q924X7-1",
"Q99KH8-1",
"Q99MW1-1",
"Q9Z2W1-1",
"Q7TNL3-1",
"Q91VJ4-1",
"Q9JI11-1",
"Q9DBU3-1",
"Q9ERK0-1",
"Q9QYZ6-1",
"Q5F2E8-1",
"Q6ZQ29-1",
"Q8BYC6-1",
"Q80UV9-1",
"O70146-1",
"Q8VCT9-1",
"Q9QZL0-1",
"Q61241-1",
"Q99JT2-1",
"Q8QZV4-1",
"O54781-1",
"O55047-1",
"Q99N57-1",
"Q60855-1",
"Q8C0V0-1",
"Q8BGW6-1",
"Q8C1R0-1",
"A2ASS6-1",
"P35761-1",
"Q8BG48-1",
"C0HKC8-1",
"Q9QYZ3-1",
"Q922Q2-1",
"Q8VDU5-1",
"O70551-1",
"P97313-1",
"P83510-1",
"P97343-1",
"Q60670-1",
"Q5GIG6-1",
"Q6P4S6-1",
"Q99PW4-1",
"Q9CQS5-1",
"Q9WTK7-1",
"Q9D411-1",
"C0HKC9-1",
"Q9JJX8-1",
"P58801-1",
"Q9Z1W9-1",
"Q80UE6-1",
"Q923J1-1",
"Q8CIR4-1",
"Q925K9-1",
"O54863-1",
"Q8BN21-1",
"Q80X41-1",
"Q80XP9-1",
"P83741-1",
"Q3UH66-1",
"O88351-1",
"Q5U452-1",
"Q9Z1T6-2",
"Q9ES70-1",
"Q9ES74-1",
"Q9JIX9-1",
"Q8BTI9-1",
"A2AQX6-1",
"J3QK59-1",
"Q3UT86-1",
"A0A087WRH8-1",
"A0A087WSA6-1",
"A0A140LI04-1",
"Q8BWE1-1",
"J3KMT3-1",
"A0A087WSF2-1",
"Q3UTA8-1",
"A0A140LJ87-1",
"A0A3B2WD63-1",
"O55028-1",
"P32490-1",
"P13185-1",
"P13186-1",
"P14680-1",
"P15442-1",
"P15790-1",
"P18961-1",
"P19454-1",
"P21965-1",
"P22204-1",
"P22216-1",
"P22517-1",
"P23292-1",
"P23293-1",
"P23561-1",
"P25333-1",
"P25341-1",
"P25389-1",
"P27466-1",
"P27636-1",
"P29295-1",
"P32600-1",
"P32944-1",
"P35169-1",
"P36003-1",
"P38615-1",
"P40494-1",
"P41695-1",
"P43565-1",
"P53894-1",
"P53974-1",
"Q03497-1",
"Q12263-1",
"P06784-1",
"P00546-1",
"P05986-1",
"P06243-1",
"P06244-1",
"P06245-1",
"P06782-1",
"P08018-1",
"P08458-1",
"P11792-1",
"P12688-1",
"P14681-1",
"P16892-1",
"P17157-1",
"P22211-1",
"P23291-1",
"P24583-1",
"P32485-1",
"P32562-1",
"P39009-1",
"P40160-1",
"P41808-1",
"P43568-1",
"P48562-1",
"P53233-1",
"P53739-1",
"Q00772-1",
"Q03407-1",
"P32491-1",
"P32581-1",
"P28708-1",
"P31374-1",
"P32328-1",
"P32350-1",
"P32361-1",
"P32789-1",
"P32801-1",
"P22219-1",
"P22209-1",
"P24719-1",
"P25390-1",
"P36002-1",
"P36004-1",
"P38147-1",
"P38622-1",
"Q01919-1",
"P39073-1",
"P38692-1",
"P38970-1",
"P38990-1",
"P38991-1",
"P39962-1",
"P43633-1",
"P47116-1",
"P53599-1",
"P34244-1",
"P36005-1",
"P38070-1",
"P38080-1",
"P38110-1",
"P38111-1",
"P38623-1",
"P38691-1",
"P53104-1",
"P53323-1",
"P54199-1",
"Q01389-1",
"Q03656-1",
"Q08217-1",
"Q03306-1",
"Q03533-1",
"Q03785-1",
"Q12003-1",
"Q12100-1",
"Q12196-1",
"Q12236-1",
"Q12469-1",
"Q12505-1",
"P43637-1",
"P47042-1",
"P50873-1",
"Q03002-1",
"Q06098-1",
"Q08732-1",
"Q12152-1",
"Q12222-1",
"Q12310-1",
"Q54HS0-1",
"Q54R98-1",
"Q54FH3-1",
"Q54RP7-1",
"Q54P26-1",
"Q54PK8-1",
"Q54VV7-1",
"Q54XZ5-1",
"Q54Y90-1",
"Q55A09-1",
"Q55BA0-1",
"Q86HW6-1",
"Q54C38-1",
"Q54DY0-1",
"Q54E34-1",
"Q54EM1-1",
"Q54ER4-1",
"Q54ET3-1",
"Q54F40-1",
"Q54FR9-1",
"Q54G43-1",
"Q54H05-1",
"Q54HD2-1",
"Q54IF2-1",
"Q54IH8-1",
"Q54IP4-1",
"Q54JQ1-1",
"Q54L00-1",
"Q54L81-1",
"Q54LH8-1",
"Q54LU8-1",
"Q54MH0-1",
"Q54MV2-1",
"Q54PX0-1",
"Q54QD5-1",
"Q54R95-1",
"Q54RB2-1",
"Q54RJ4-1",
"Q54RR9-1",
"Q54RV3-1",
"Q54RZ7-1",
"Q54SC4-1",
"Q54SK3-1",
"Q54TA3-1",
"Q54TH6-1",
"Q54TN4-1",
"Q54U31-1",
"Q54U65-1",
"Q54UA9-1",
"Q54UZ1-1",
"Q54V35-1",
"Q54V83-1",
"Q54VC0-1",
"Q54VU4-1",
"Q54WC0-1",
"Q54WD7-1",
"Q54WE5-1",
"Q54WW7-1",
"Q54XJ4-1",
"Q54XX5-1",
"Q54XY6-1",
"Q54Y06-1",
"Q54Y55-1",
"Q54YZ5-1",
"Q54ZN3-1",
"Q552C1-1",
"Q552E9-1",
"Q552Z2-1",
"Q553E9-1",
"Q556J6-1",
"Q559A2-1",
"Q559T8-1",
"Q55A55-1",
"Q55CA6-1",
"Q55CE0-1",
"Q55CW2-1",
"Q55CW3-1",
"Q55DJ9-1",
"Q55DK2-1",
"Q55DU7-1",
"Q55EI8-1",
"Q55F45-1",
"Q55FJ6-1",
"Q55FV4-1",
"Q55FV5-1",
"Q55GC2-1",
"Q55GE6-1",
"Q55GG4-1",
"Q55GS4-1",
"Q55GU0-1",
"Q6XHA7-1",
"Q75JN1-1",
"Q76P07-1",
"Q869L4-1",
"Q869T7-1",
"Q869X3-1",
"Q86A12-1",
"Q86HG9-1",
"Q86I06-1",
"Q8MYF1-1",
"Q8SSV3-1",
"Q9NGW9-1",
"P34099-1",
"Q1ZXI5-1",
"Q54D75-1",
"Q54EY4-1",
"Q54UL8-1",
"Q558U1-1",
"Q5VJL3-1",
"B0G126-1",
"O61122-1",
"O61125-1",
"P0CD62-1",
"P28178-1",
"P34100-1",
"P34101-1",
"P34102-1",
"P34103-1",
"P34112-1",
"P34117-1",
"P42525-1",
"P54644-1",
"P54685-1",
"Q02720-1",
"Q1ZXC8-1",
"Q1ZXD6-1",
"Q1ZXH2-1",
"Q1ZXR2-1",
"Q23915-1",
"Q54B33-1",
"Q54B48-1",
"Q54BC9-1",
"Q54BF0-1",
"Q54C18-1",
"Q54C71-1",
"Q54DC8-1",
"Q54DF2-1",
"Q54DK3-1",
"Q54EG9-1",
"Q54GY6-1",
"Q54H45-1",
"Q54H46-1",
"Q54HC6-1",
"Q54I36-1",
"Q54IE8-1",
"Q54JC7-1",
"Q54JG7-1",
"Q54LR6-1",
"Q54M77-1",
"Q54MY9-1",
"Q54P47-1",
"Q54PK9-1",
"Q54Q69-1",
"Q54QB1-1",
"Q54QI2-1",
"Q54QQ1-1",
"Q54QV3-1",
"Q54R82-1",
"Q54RB7-1",
"Q54S77-1",
"Q54T05-1",
"Q54TA1-1",
"Q54TM7-1",
"Q54TW2-1",
"Q54UC0-1",
"Q54VD8-1",
"Q54VI1-1",
"Q54W07-1",
"Q54WJ0-1",
"Q54WS5-1",
"Q54WX4-1",
"Q54XL6-1",
"Q54XQ2-1",
"Q54Y26-1",
"Q54YF2-1",
"Q550K8-1",
"Q550L8-1",
"Q551H4-1",
"Q552C6-1",
"Q556Q3-1",
"Q556S2-1",
"Q556Y4-1",
"Q557G1-1",
"Q55BN8-1",
"Q55CL6-1",
"Q55CY9-1",
"Q55CZ1-1",
"Q55D99-1",
"Q55DD4-1",
"Q55DJ8-1",
"Q55E58-1",
"Q55EC7-1",
"Q55FS2-1",
"Q55FT4-1",
"Q55GJ2-1",
"Q55GV3-1",
"Q6B9X6-1",
"Q6XHA5-1",
"Q6XHB2-1",
"Q75JK0-1",
"Q76NV1-1",
"Q869N2-1",
"Q86AE1-1",
"Q86AT8-1",
"Q86C65-1",
"Q86CS2-1",
"Q86HN7-1",
"Q86IX1-1",
"Q8MVR1-1",
"Q8SSS9-1",
"Q8SSY6-1",
"Q8T2I8-1",
"Q95YH0-1",
"O61267-1",
"P13677-1",
"P23573-1",
"P51123-1",
"Q00168-1",
"Q23977-1",
"Q24210-3",
"Q9VKN7-1",
"O62618-1",
"P10676-1",
"P18431-2",
"P23647-1",
"P52304-1",
"P83098-1",
"P83104-1",
"Q03042-1",
"Q70PP2-1",
"Q8T0S6-1",
"P12370-1",
"Q05652-1",
"Q9VXE5-1",
"P83103-1",
"Q7KRY6-1",
"Q95UN8-1",
"Q8INB9-1",
"A0A0B4KHX7-1",
"A1Z9X0-1",
"P08181-1",
"P11346-1",
"M9PI41-1",
"Q9VM90-1",
"Q9VXE3-1",
"A1ZBH7-1",
"Q9W002-1",
"P83099-1",
"Q9NIV1-1",
"O76324-1",
"P13678-1",
"P16912-1",
"P23572-1",
"P40417-3",
"P48609-1",
"P49071-1",
"P49762-1",
"P54367-1",
"P83100-1",
"P83102-1",
"P92208-1",
"Q03043-1",
"Q0KHT7-1",
"Q24324-1",
"Q5EAK6-1",
"Q9VPC0-1",
"Q9VXG8-1",
"Q9W354-1",
"A1Z7T0-1",
"O61443-1",
"O97143-1",
"P05130-1",
"P16911-1",
"P49657-1",
"Q9NI63-1",
"Q9V3Q6-1",
"Q9VA38-1",
"Q9VK45-1",
"Q9W0V1-4",
"P54360-1",
"Q9VT57-1",
"Q9VI13-1",
"A1ZBC4-1",
"Q8IMC6-1",
"Q8IR79-1",
"Q9V3D5-1",
"Q0KHQ5-1",
"Q0KHV6-1",
"Q9NBK5-1",
"Q7PLI7-1",
"X2JAG8-1",
"O61661-1",
"A4VCL2-2",
"A0A0B4KHT3-1",
"A0A4D6K823-1",
"A1ZBL9-1",
"Q9VP22-1",
"Q9W1B0-1",
"Q9V3I5-1",
"Q9VRJ6-1",
"Q8T9L5-1",
"Q94533-1",
"Q9VUQ9-1",
"Q9VGF9-1",
"Q9VBU2-1",
"Q9VR42-1",
"Q9VL34-1",
"Q9VTL5-1",
"Q95TN8-1",
"Q9VCV0-1",
"Q8MSQ4-1",
"Q9VE06-1",
"Q9VJ30-1",
"Q9VXN5-1",
"M9PGC5-1",
"Q9VN23-1",
"M9NGC6-1",
"O61444-1",
"O62602-1",
"Q9VUV4-1",
"Q9VMY8-1",
"Q9VD82-1",
"A0A6M3Q7C8-1",
"Q9W3N8-1",
"Q95SH0-1",
"Q9VI84-1",
"Q9VEN3-1"
],
"evidence": [
{
"id": "17989",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17989"
}
]
},
{
"id": "46608",
"name": "",
"equation": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"B2DD29-1",
"D3ZML2-1",
"O08875-1",
"O35831-1",
"P57760-1",
"D3ZHP7-1",
"D4A280-1",
"E9PTG8-1",
"O35832-1",
"O54748-1",
"Q62868-1",
"D3ZBE5-1",
"P59895-1",
"O55099-1",
"O88764-1",
"P59241-1",
"Q91XS8-1",
"Q63644-1",
"Q7TQP6-1",
"Q9Z2P5-1",
"P11345-1",
"P11275-1",
"F1LYY7-1",
"Q9JIH7-1",
"Q5XIT0-1",
"P14056-1",
"P35426-1",
"P51952-1",
"P63086-1",
"Q5U2X5-1",
"Q63117-1",
"F1M7Y5-1",
"P08413-1",
"P47196-1",
"P47197-1",
"P97874-1",
"Q03114-1",
"Q3MJK5-1",
"Q09137-1",
"Q4V8A3-1",
"P54645-1",
"Q63686-1",
"P0C1X8-1",
"P19139-1",
"D4A7V9-1",
"Q62915-1",
"Q63184-1",
"Q63484-1",
"Q9Z1Z1-1",
"O70444-1",
"P0C0R5-1",
"O08874-1",
"O88831-1",
"P18265-1",
"P26794-1",
"P46892-1",
"Q4KM34-1",
"Q4KM47-1",
"Q66HE7-1",
"Q6XUX2-1",
"Q63185-1",
"Q63470-1",
"Q62673-1",
"Q63433-1",
"P53669-1",
"P53670-1",
"Q63699-1",
"Q641Z4-1",
"Q91ZN7-1",
"P39951-1",
"B2GUY1-1",
"A1A5Q6-1",
"B0LT89-1",
"F1LP90-1",
"O08815-1",
"O88850-1",
"P00539-1",
"P0C865-1",
"P27791-1",
"P63319-1",
"P68182-1",
"P97924-1",
"Q01986-1",
"Q06226-1",
"Q53UA7-1",
"Q62862-1",
"Q63454-1",
"Q63531-1",
"Q63562-1",
"Q63572-1",
"Q64617-1",
"Q66HA1-1",
"Q7TNL4-1",
"Q62762-1",
"O55173-1",
"O70150-1",
"P05696-1",
"P09216-1",
"P11730-1",
"P13234-1",
"P15791-1",
"P68403-1",
"P97633-1",
"P97756-1",
"Q62761-1",
"Q62763-1",
"D4AE59-1",
"B1WBU5-1",
"D3ZGQ5-1",
"F1M0Z1-1",
"P13286-1",
"P49187-1",
"Q5RKH1-1",
"Q62829-1",
"Q63638-1",
"Q9JLS3-1",
"Q9JM01-1",
"Q9R011-1",
"Q9R012-1",
"D3ZSZ3-1",
"Q06486-1",
"Q62726-1",
"Q63450-1",
"Q4KSH7-1",
"Q5XIS9-1",
"Q63285-1",
"Q63553-1",
"P67999-1",
"O88664-1",
"O08678-1",
"O08679-1",
"Q99J82-1",
"Q7TNJ7-1",
"Q64303-1",
"Q66HE5-1",
"Q64595-1",
"P09215-1",
"P49185-1",
"P09217-1",
"P36506-1",
"P35465-1",
"P20793-1",
"Q7TPK6-1",
"O88506-1",
"D4A229-1",
"Q8R4V0-1",
"Q8R4U9-1",
"Q924U5-1",
"Q9WTQ0-1",
"Q9WTQ1-1",
"Q9Z2A6-1",
"Q9Z335-1",
"D3ZG83-1",
"P21708-1",
"P27704-1",
"Q4V793-1",
"Q5MPA9-1",
"Q5U2N4-1",
"Q62925-1",
"Q63538-1",
"Q66H84-1",
"Q9WTY9-1",
"O54874-1",
"Q8VHF0-1",
"A0A0G2JZW9-1",
"Q924I2-1",
"P42346-1",
"P49186-1",
"Q4G050-1",
"P70618-1",
"Q925B3-1",
"Q63796-1",
"Q7TT49-1",
"Q810W7-1",
"Q9R1U5-1",
"F1LRA7-1",
"D3ZHL6-1",
"D4A454-1",
"D3ZXB1-1",
"P0C8E4-1",
"P18266-1",
"D3Z8I4-1",
"D3ZY07-1",
"D4AE24-1",
"F1M419-1",
"D3ZSB7-1",
"A0A0G2K5L3-1",
"A0A8I6A165-1",
"A4L9P5-1",
"D4A6T9-1",
"E9PSL7-1",
"D4ACL8-1",
"F1LXF1-1",
"D3Z822-1",
"A0A8I6AQN6-1",
"D3Z8E0-1",
"F1M7N7-1",
"A0A8I6AWX7-1",
"A0A8I5ZZZ6-1",
"D3ZMG0-1",
"Q9QY78-1",
"E9PSK5-1",
"A0A0G2KB60-1",
"Q63945-1",
"F1LNN8-1",
"A0A8I5ZMP0-1",
"M0RD40-1",
"A0A0G2JVL3-1",
"A0A8I5ZP97-1",
"D3Z837-1",
"D3ZL21-1",
"A0A8I6AUJ4-1",
"F1M7G0-1",
"D4A355-1",
"D3ZCD7-1",
"D3ZFL3-1",
"A0A0G2JUP3-1",
"A0A8I5ZNK2-1",
"D3ZRJ7-1",
"D4AD76-1",
"A0A8I6ANX6-1",
"B5DFG1-1",
"A0A8I6A0F8-1",
"F1LNJ1-1",
"A0A8I6AEL0-1",
"A0A8I6G1H3-1",
"A0A8I6ATH0-1",
"D3ZTD1-1",
"M0RBT0-1",
"A0A8I5Y8C3-1",
"F7FMK8-1",
"A0A0G2K578-1",
"A0A8I6GK52-1",
"D4A6T6-1",
"A0A8I6ATM1-1",
"F1LUY7-1",
"A0A8I6AJD2-1",
"M0RDM0-1",
"M0RD88-1",
"A0A8I6A7D1-1",
"A0A8J8XEH6-1",
"A0A8I6AD01-1",
"A0A8I6AJX5-1",
"A6KB61-1",
"A0A8I6ACR1-1",
"P11980-1",
"A0A8I5ZUX6-1",
"A0A8I5ZSS7-1",
"G3V783-1",
"A0A8I6GI15-1",
"M0R777-1",
"Q6V9V9-1",
"A0A8I5ZUS1-1",
"A0A0G2K6V9-1",
"D4A9H8-1",
"D3ZJ84-1",
"A0A8I5ZV60-1",
"B1WBT4-1",
"A0A8I6A574-1",
"Q4KLN3-1",
"A0A8I6AHQ6-1",
"A0A0G2K5C7-1",
"Q6V9Y3-1",
"D3ZDM6-1",
"D3ZD18-1",
"Q5PQT0-1",
"Q6V9Y2-1",
"D3ZQN8-1",
"F1LWF2-1",
"F1M9D0-1",
"A0A8I5ZT61-1",
"A0A8I5ZN46-1",
"A0A8I5Y7S3-1",
"A0A0G2K2T8-1",
"A0A0G2JWX7-1",
"A0A0G2JXR8-1",
"D3ZSY9-1",
"D4A3H8-1",
"D4A3D9-1",
"D3ZZK7-1",
"A0A8I5ZLV4-1",
"A0A0G2KAH6-1",
"A0A0G2QC55-1",
"A0A8I5ZR62-1",
"A0A8I6A1U5-1",
"A0A8I6A8U4-1",
"A0A8I6A9X0-1",
"A0A8I6ACE8-1",
"D3ZBS8-1",
"D3ZEK4-1",
"A0A8I6GM03-1",
"Q4KSH6-1",
"F1LWJ6-1",
"F1LTP9-1",
"E9PSM2-1",
"D4A949-1",
"A0A8I6A7V5-1",
"A0A8I6GBQ0-1",
"A0A8I6AAX5-1",
"A0A8I6GDY5-1",
"A0A8I6GJV1-1",
"A0A8I6G980-1",
"A0A8I5ZS27-1",
"A0A8I5ZYM4-1",
"A6HK01-1",
"A0A0G2K490-1",
"M0R7E7-1",
"A0A8I6GK16-1",
"A0A8I6GKS8-1",
"A0A8I6G5Z0-1",
"Q925D6-1",
"A0A8I5ZKJ9-1",
"Q9HCP0-1",
"P0C263-1",
"Q6ZMQ8-1",
"Q2M2I8-1",
"P80192-1",
"P31751-1",
"Q07912-1",
"Q5VT25-1",
"O43293-1",
"P53779-1",
"Q9P0L2-1",
"Q13164-1",
"Q13131-1",
"P21127-1",
"Q9BWU1-1",
"Q9UQ88-1",
"Q00537-1",
"Q8IZL9-1",
"Q9UQB9-1",
"Q8IWQ3-1",
"Q9NYV4-1",
"Q13315-1",
"Q96GD4-1",
"P06493-1",
"Q00526-1",
"O60566-1",
"O76039-2",
"O94921-1",
"Q00535-1",
"Q8IVW4-1",
"Q9Y243-1",
"Q07002-2",
"P50613-1",
"Q92772-1",
"P10398-1",
"Q8NFD2-1",
"O43683-1",
"O14965-1",
"P24941-1",
"Q15131-1",
"Q9NSY1-1",
"P33076-1",
"Q86TB3-1",
"P50750-1",
"Q14004-1",
"P11802-1",
"Q8TDC3-1",
"P54646-1",
"O00311-1",
"Q00536-1",
"P11274-1",
"P49336-1",
"Q96QP1-1",
"Q96L96-1",
"P31749-1",
"Q13535-1",
"O96017-1",
"P49760-1",
"Q5MAI5-1",
"Q00532-1",
"Q00534-1",
"P49761-4",
"Q9HAZ1-1",
"P49759-1",
"Q96Q40-1",
"P41279-1",
"P15056-1",
"O14757-1",
"P68400-1",
"O14936-1",
"Q6XUX3-1",
"Q9Y463-1",
"Q76MJ5-1",
"Q9P2K8-1",
"P19525-1",
"Q8N568-1",
"Q09013-9",
"Q9NR20-1",
"Q9NZJ5-1",
"O15075-1",
"Q9C098-1",
"O14578-1",
"P53355-1",
"Q8IXL6-1",
"Q13627-1",
"Q9Y4B6-1",
"Q9BQI3-1",
"Q9UIK4-1",
"Q92630-1",
"Q8NEV1-1",
"O43781-1",
"O75460-1",
"P19784-1",
"Q13557-1",
"Q13976-1",
"P41743-1",
"P48729-1",
"Q15418-1",
"P51617-1",
"Q15349-1",
"Q9UQM7-1",
"Q9NRM7-1",
"O95835-1",
"Q9H2X6-1",
"Q86Z02-1",
"Q16566-1",
"Q6P2M8-1",
"P78368-1",
"Q96NX5-1",
"Q9Y6M4-1",
"P22612-1",
"P57058-1",
"Q13554-1",
"Q9H422-1",
"Q9NWZ3-1",
"Q8IWU2-1",
"Q8N5S9-1",
"O14976-1",
"Q8NE63-1",
"Q13555-1",
"Q96RR4-1",
"Q15139-1",
"P11801-1",
"O94806-1",
"Q13237-1",
"Q96S38-1",
"Q9UK32-1",
"Q8N752-1",
"Q14012-1",
"P05129-1",
"P51812-1",
"Q9UBS0-1",
"O60229-1",
"Q05655-1",
"Q02156-1",
"P17252-1",
"P05771-1",
"P53667-1",
"Q9UPZ9-1",
"Q13418-1",
"P23443-1",
"P49674-1",
"Q8TF76-1",
"Q04759-1",
"Q9BZL6-1",
"Q05513-1",
"Q6VAB6-1",
"P49840-1",
"P49841-1",
"P48730-1",
"O75676-1",
"O75582-1",
"P24723-1",
"Q8IVT5-1",
"Q8IU85-1",
"Q96GX5-1",
"P22694-1",
"P17612-1",
"Q16659-1",
"Q9UBE8-1",
"Q02750-1",
"O14733-1",
"Q8TD08-1",
"Q9Y2U5-1",
"Q6P0Q8-1",
"P46734-1",
"P51957-1",
"Q6ZN16-1",
"Q6DT37-1",
"Q5VST9-1",
"Q9Y5S2-1",
"Q9UQ07-1",
"P28482-1",
"P27361-1",
"P00540-1",
"O75914-1",
"Q99759-1",
"Q99558-1",
"P51955-1",
"Q8IW41-1",
"Q9Y6R4-1",
"P51956-1",
"Q6P3R8-1",
"Q13163-1",
"Q13233-1",
"O60307-1",
"Q56UN5-1",
"O95382-1",
"Q02779-1",
"O15021-5",
"P45985-1",
"Q86SG6-1",
"Q6ZWH5-1",
"Q86YV6-1",
"Q8WXR4-1",
"Q8NEV4-1",
"Q6A1A2-1",
"P31152-1",
"O15264-1",
"P52564-1",
"Q96QS6-1",
"O60285-1",
"Q7Z2Y5-1",
"Q15759-1",
"P49137-1",
"Q16644-1",
"Q96L34-1",
"P53778-1",
"O95819-1",
"Q8N4C8-1",
"P36507-1",
"Q96Q04-1",
"P53671-1",
"Q8NG66-1",
"Q9Y4K4-1",
"Q9HBH9-1",
"Q96PY6-1",
"Q9H093-1",
"O43318-1",
"P45983-1",
"Q16584-1",
"Q7KZI7-1",
"Q9BUB5-1",
"Q8IY84-1",
"P45984-1",
"Q99683-1",
"O43283-1",
"Q12852-1",
"Q16539-1",
"Q38SD2-1",
"Q92918-1",
"Q9Y2H9-1",
"Q8TD19-1",
"Q5TCX8-1",
"Q13153-1",
"Q9NYL2-1",
"P20794-1",
"Q8IVH8-1",
"Q12851-1",
"Q14680-1",
"Q5S007-1",
"P42345-1",
"P27448-5",
"Q9NYY3-1",
"Q96RG2-1",
"Q9Y6S9-1",
"Q15772-5",
"Q16816-1",
"Q16513-1",
"Q99570-1",
"Q86V86-1",
"Q16512-1",
"P57059-1",
"Q13464-1",
"Q9P286-1",
"Q8N165-1",
"Q99640-1",
"P57078-1",
"O14730-1",
"O43353-1",
"O96013-1",
"Q9H4B4-1",
"O43930-1",
"Q13523-1",
"Q9HBY8-2",
"O75116-1",
"Q52WX2-1",
"O00141-1",
"P0C264-1",
"Q96BR1-1",
"Q9P1W9-1",
"Q6P5Z2-1",
"Q96LW2-1",
"O15530-1",
"Q9NQU5-1",
"Q9BRS2-1",
"Q13546-1",
"P11309-1",
"Q9NRH2-1",
"Q9H0K1-1",
"Q13177-1",
"P51817-1",
"P04049-1",
"O00444-1",
"P78527-1",
"Q96Q15-1",
"Q96S44-1",
"Q9Y572-1",
"Q9BVS4-1",
"Q9BXM7-1",
"P53350-1",
"O95747-1",
"O00506-1",
"Q15208-1",
"Q8N2I9-1",
"Q9BXU1-1",
"Q9BYT3-1",
"Q9UEE5-1",
"O94768-1",
"Q8TDR2-1",
"Q9BX84-1",
"Q96QT4-1",
"Q96KB5-1",
"A0A0B4J2F2-1",
"Q9NRP7-1",
"P78362-1",
"Q9BXA7-1",
"O75385-1",
"Q5TCY1-1",
"Q9Y3S1-1",
"Q8WZ42-1",
"O75716-1",
"Q13188-1",
"Q13043-1",
"Q96PN8-1",
"Q9Y2H1-1",
"O75962-1",
"Q9UPE1-1",
"Q15569-1",
"Q8IYT8-1",
"Q6PHR2-1",
"Q96C45-1",
"Q9H2K8-1",
"Q9Y6E0-1",
"Q9H2G2-1",
"Q96S53-1",
"P21675-2",
"Q7L7X3-1",
"Q9UL54-1",
"Q9UKE5-1",
"Q96SB4-2",
"Q9UEW8-1",
"Q15831-1",
"Q9BXA6-1",
"Q96PF2-1",
"Q59H18-2",
"Q6SA08-1",
"Q6IQ55-1",
"Q8TAS1-1",
"P33981-1",
"Q99986-1",
"O94804-1",
"Q9P289-1",
"Q8WU08-1",
"Q9NY57-1",
"Q9UHD2-1",
"Q86UX6-1",
"Q9UKI8-1",
"Q86UE8-1",
"Q86Y07-1",
"Q9BYP7-1",
"Q9Y2K2-5",
"Q96J92-1",
"Q9H4A3-1",
"Q9HC98-1",
"Q8TDX7-1",
"O14920-1",
"P14618-1",
"Q14296-1",
"Q5SYL1-1",
"E9Q3S4-1",
"Q62070-1",
"Q91Y86-1",
"Q9Z188-1",
"Q9JKK8-1",
"Q05512-1",
"Q66L42-1",
"Q9Z1B7-1",
"Q8C050-1",
"Q3UHJ0-1",
"Q7TT50-1",
"Q61831-1",
"Q99MQ3-1",
"P49025-1",
"Q03141-1",
"Q9Z0R0-1",
"Q69ZM6-1",
"Q9WVS8-1",
"Q7TSJ6-1",
"A0A3B2WD63-1",
"Q8VDU5-1",
"A0A087WSA6-1",
"Q9WVC6-1",
"P04627-1",
"Q60823-1",
"O54967-1",
"Q924C5-1",
"Q8BRK8-1",
"Q91ZB0-1",
"P31750-1",
"Q5EG47-1",
"O88445-1",
"Q5RJI5-1",
"Q9Z1S0-1",
"O08901-1",
"P49615-1",
"Q04899-1",
"Q3TZA2-1",
"Q8BLF2-1",
"Q8R3L8-1",
"Q9WUA6-1",
"P24788-1",
"O35495-1",
"Q14AX6-1",
"Q3UMM4-1",
"Q64261-1",
"Q8BWD8-1",
"Q3UTQ8-1",
"Q8CEQ0-1",
"Q03147-1",
"Q8K0D0-1",
"O70589-1",
"Q8BZ25-1",
"O35491-1",
"O35493-1",
"Q9Z265-1",
"Q69ZA1-1",
"Q80YP0-1",
"Q9JHU3-1",
"Q9QUK0-1",
"P11440-1",
"Q62388-1",
"Q91Z96-1",
"O35280-1",
"O35492-1",
"P28028-3",
"Q99J95-1",
"P30285-1",
"P97377-1",
"Q9Z0H0-1",
"O70126-1",
"P97477-1",
"P79621-1",
"Q04735-1",
"Q3V3A1-1",
"Q69Z98-1",
"Q6PAJ1-1",
"Q9CXB8-1",
"P22518-1",
"P54265-1",
"Q6XUX1-1",
"Q03963-1",
"Q9Z2B5-1",
"O54833-1",
"Q80TR8-1",
"Q60737-1",
"Q80YE7-1",
"Q8BWQ5-1",
"Q9JLM8-1",
"Q6PGN3-1",
"Q99KY4-1",
"Q61214-1",
"Q8VDF3-1",
"Q922Y0-1",
"O54784-1",
"Q9EQY0-1",
"Q8BI55-1",
"Q9Z2E3-1",
"Q5U4C9-1",
"Q5MJS3-1",
"Q9Z2R9-1",
"Q9QZ05-1",
"Q6PHZ2-1",
"Q91YS8-1",
"Q923T9-1",
"P68404-1",
"Q91YA2-1",
"P68181-1",
"Q7TPS0-1",
"Q8BK63-1",
"Q8BTH8-1",
"Q8C4X2-1",
"Q62101-1",
"Q8K1Y2-1",
"P16054-1",
"O88904-1",
"Q9ERH7-1",
"Q3V016-1",
"Q8R4K2-1",
"Q8BVP5-1",
"Q8BW96-1",
"Q9QYK9-1",
"P08414-1",
"Q8C078-1",
"P53349-1",
"Q3U1V8-1",
"Q80XI6-1",
"Q80YE4-1",
"Q3TYD6-1",
"O08648-1",
"Q07174-1",
"Q1HKZ5-1",
"Q61083-1",
"Q3U214-1",
"Q2NL51-1",
"Q8VBY2-1",
"P49138-1",
"P53668-1",
"Q9Z2B9-1",
"P70218-1",
"Q62406-1",
"Q61084-1",
"O88866-1",
"Q61410-1",
"P20444-1",
"Q62074-1",
"Q9WUT3-1",
"P0C605-1",
"P23298-1",
"P63318-1",
"P18653-1",
"P18654-1",
"Q02111-1",
"Q8BLK9-1",
"Q9WUL6-1",
"Q9Z1M4-1",
"Q8C0P0-1",
"P28652-1",
"Q9WV60-1",
"Q8BZ03-1",
"Q60700-1",
"Q61161-1",
"Q91VB2-1",
"Q8VHJ5-1",
"Q9QZR5-1",
"O55222-1",
"Q9JMK2-1",
"O54785-1",
"O35099-1",
"O54992-1",
"Q5S006-1",
"P28867-1",
"Q8BSK8-1",
"Q8CIP4-1",
"Q811L6-1",
"Q8BPM2-1",
"A2CG49-1",
"Q62073-1",
"Q8BYR2-1",
"Q9R1L5-1",
"Q9WTR2-1",
"A2AQW0-1",
"Q8VDG6-1",
"P11798-1",
"Q02956-1",
"Q04859-1",
"Q99JP0-1",
"P97820-1",
"Q61097-1",
"Q3UHC2-1",
"Q3UVC0-1",
"Q5XJV6-1",
"Q60592-1",
"Q9DC28-1",
"Q9JKV2-1",
"Q9ESL4-1",
"P05132-1",
"P63085-1",
"P31938-1",
"Q9WVS7-1",
"P00536-1",
"Q3UMW7-1",
"Q61532-1",
"Q61846-1",
"Q6P5G0-1",
"Q1EG27-1",
"Q8K3H5-1",
"Q5SUV5-1",
"Q9Z2A0-1",
"Q8VD65-1",
"Q8C015-1",
"P47809-1",
"Q3UU96-1",
"P70236-1",
"Q91ZR4-1",
"Q7TSC3-1",
"Q9R0A5-1",
"Q641K5-1",
"Q9R0G8-1",
"Q3ULB5-1",
"Q61036-1",
"Q8BTW9-1",
"Q8CEE6-1",
"P58750-1",
"P06803-1",
"P53351-1",
"Q60806-1",
"Q8K045-1",
"P07934-1",
"P70268-1",
"O08911-1",
"Q63844-1",
"Q80Y86-1",
"Q9WUI1-1",
"O35942-1",
"Q8QZR7-1",
"Q8BWW9-1",
"Q8K1R7-1",
"Q63932-1",
"Q8BHI9-1",
"O09110-1",
"O54949-1",
"Q8CE90-1",
"Q8C0Q4-1",
"O08605-1",
"A2AAJ9-1",
"P47811-1",
"Q8CDB0-1",
"P51954-1",
"Q8CIN4-1",
"Q80UW5-1",
"Q8BZN4-1",
"Q9WVS4-1",
"Q9WTU6-1",
"Q9Z1J2-1",
"Q9JLN9-1",
"O88643-1",
"Q07832-1",
"Q3UGM2-1",
"Q9JM52-1",
"Q6P9R2-1",
"Q64702-1",
"Q61136-1",
"Q922R0-1",
"P70336-1",
"Q8R2S1-1",
"P0C5K0-1",
"P0C5K1-1",
"Q9Z0G2-1",
"Q8C0X8-1",
"Q9QYZ4-1",
"Q62407-1",
"Q8C0V7-1",
"O54988-1",
"Q9JJ78-1",
"Q3UVR3-1",
"Q9D2E1-1",
"Q6PCN3-1",
"Q9ESG9-1",
"A2KF29-1",
"Q8BKX6-1",
"A0AUV4-1",
"Q7TSE6-1",
"Q9JI10-1",
"Q0KL02-1",
"Q3U3Q1-1",
"Q3V129-1",
"Q9QY01-1",
"P70335-1",
"Q8CFH6-1",
"Q9WUN2-1",
"Q8QZX0-1",
"Q8C0N0-1",
"Q9ERE3-1",
"Q9QZS5-1",
"O88697-1",
"Q80ZW0-1",
"O55098-1",
"Q924X7-1",
"Q99KH8-1",
"Q99MW1-1",
"Q9Z2W1-1",
"Q7TNL3-1",
"Q91VJ4-1",
"Q9JI11-1",
"Q9DBU3-1",
"Q9ERK0-1",
"Q9QYZ6-1",
"Q5F2E8-1",
"Q6ZQ29-1",
"Q8BYC6-1",
"Q80UV9-1",
"O70146-1",
"Q8VCT9-1",
"Q9QZL0-1",
"Q61241-1",
"Q99JT2-1",
"Q8QZV4-1",
"O54781-1",
"O55047-1",
"Q99N57-1",
"Q60855-1",
"Q8C0V0-1",
"Q8BGW6-1",
"Q8C1R0-1",
"A2ASS6-1",
"P35761-1",
"Q8BG48-1",
"C0HKC8-1",
"Q9QYZ3-1",
"Q922Q2-1",
"O70551-1",
"O70405-1",
"P97313-1",
"P83510-1",
"P97343-1",
"Q60670-1",
"Q5GIG6-1",
"Q6P4S6-1",
"Q99PW4-1",
"Q9CQS5-1",
"Q9WTK7-1",
"Q9D411-1",
"C0HKC9-1",
"Q9JJX8-1",
"P58801-1",
"Q9Z1W9-1",
"Q923J1-1",
"Q8CIR4-1",
"Q925K9-1",
"O54863-1",
"Q8BN21-1",
"Q80X41-1",
"Q80XP9-1",
"Q4FZD7-1",
"P83741-1",
"Q3UH66-1",
"Q80UE6-1",
"O88351-1",
"Q5U452-1",
"Q9ES70-1",
"Q9ES74-1",
"P52480-1",
"Q9JIX9-1",
"A2AQX6-1",
"J3QK59-1",
"Q3UT86-1",
"A0A087WRH8-1",
"A0A140LI04-1",
"Q8BWE1-1",
"J3KMT3-1",
"A0A087WSF2-1",
"Q3UTA8-1",
"A0A140LJ87-1",
"P13185-1",
"P13186-1",
"P14680-1",
"P15442-1",
"P15790-1",
"P18961-1",
"P19454-1",
"P21965-1",
"P22204-1",
"P22216-1",
"P22517-1",
"P23292-1",
"P23293-1",
"P23561-1",
"P25333-1",
"P25341-1",
"P25389-1",
"P27466-1",
"P27636-1",
"P29295-1",
"P32490-1",
"P32600-1",
"P32944-1",
"P35169-1",
"P36003-1",
"P38615-1",
"P40494-1",
"P41695-1",
"P43565-1",
"P53894-1",
"P53974-1",
"Q03497-1",
"Q12263-1",
"P00546-1",
"P05986-1",
"P06243-1",
"P06244-1",
"P06245-1",
"P06782-1",
"P06784-1",
"P08018-1",
"P08458-1",
"P11792-1",
"P12688-1",
"P14681-1",
"P16892-1",
"P17157-1",
"P22211-1",
"P23291-1",
"P24583-1",
"P32485-1",
"P32562-1",
"P39009-1",
"P40160-1",
"P41808-1",
"P43568-1",
"P48562-1",
"P53233-1",
"P53739-1",
"Q00772-1",
"Q03407-1",
"P28708-1",
"P31374-1",
"P32328-1",
"P32350-1",
"P32361-1",
"P32491-1",
"P32581-1",
"P32789-1",
"P32801-1",
"P22219-1",
"P22209-1",
"P24719-1",
"P25390-1",
"P36002-1",
"P36004-1",
"P38147-1",
"P38622-1",
"Q01919-1",
"P43633-1",
"P38692-1",
"P38970-1",
"P38990-1",
"P38991-1",
"P39073-1",
"P39962-1",
"P47116-1",
"P53599-1",
"P34244-1",
"P36005-1",
"P38070-1",
"P38080-1",
"P38110-1",
"P38111-1",
"P38623-1",
"P38691-1",
"P53104-1",
"P53323-1",
"P54199-1",
"Q01389-1",
"Q03656-1",
"Q08217-1",
"Q03306-1",
"Q03533-1",
"Q03785-1",
"Q12003-1",
"Q12100-1",
"Q12196-1",
"Q12236-1",
"Q12469-1",
"Q12505-1",
"P43637-1",
"P47042-1",
"P50873-1",
"Q03002-1",
"Q06098-1",
"Q08732-1",
"Q12152-1",
"Q12222-1",
"Q12310-1",
"Q54FH3-1",
"Q54R98-1",
"Q54RP7-1",
"Q55FJ6-1",
"Q55GG4-1",
"Q54C38-1",
"Q54DY0-1",
"Q54E34-1",
"Q54EM1-1",
"Q54ER4-1",
"Q54ET3-1",
"Q54F40-1",
"Q54FR9-1",
"Q54G43-1",
"Q54H05-1",
"Q54HD2-1",
"Q54IF2-1",
"Q54IH8-1",
"Q54IP4-1",
"Q54JQ1-1",
"Q54L00-1",
"Q54L81-1",
"Q54LH8-1",
"Q54LU8-1",
"Q54MH0-1",
"Q54MV2-1",
"Q54P26-1",
"Q54PK8-1",
"Q54PX0-1",
"Q54QD5-1",
"Q54R95-1",
"Q54RB2-1",
"Q54RJ4-1",
"Q54RR9-1",
"Q54RV3-1",
"Q54RZ7-1",
"Q54SC4-1",
"Q54SK3-1",
"Q54TA3-1",
"Q54TH6-1",
"Q54TN4-1",
"Q54U31-1",
"Q54U65-1",
"Q54UA9-1",
"Q54UZ1-1",
"Q54V35-1",
"Q54V83-1",
"Q54VC0-1",
"Q54VU4-1",
"Q54VV7-1",
"Q54WC0-1",
"Q54WD7-1",
"Q54WE5-1",
"Q54WW7-1",
"Q54XJ4-1",
"Q54XX5-1",
"Q54XY6-1",
"Q54XZ5-1",
"Q54Y06-1",
"Q54Y55-1",
"Q54Y90-1",
"Q54YZ5-1",
"Q54ZN3-1",
"Q552C1-1",
"Q552E9-1",
"Q552Z2-1",
"Q553E9-1",
"Q556J6-1",
"Q559A2-1",
"Q559T8-1",
"Q55A09-1",
"Q55A55-1",
"Q55BA0-1",
"Q55CA6-1",
"Q55CE0-1",
"Q55CW2-1",
"Q55CW3-1",
"Q55DJ9-1",
"Q55DK2-1",
"Q55DU7-1",
"Q55EI8-1",
"Q55F45-1",
"Q55FV4-1",
"Q55FV5-1",
"Q55GC2-1",
"Q55GE6-1",
"Q55GS4-1",
"Q55GU0-1",
"Q6XHA7-1",
"Q75JN1-1",
"Q76P07-1",
"Q869L4-1",
"Q869T7-1",
"Q869X3-1",
"Q86A12-1",
"Q86HG9-1",
"Q86HW6-1",
"Q86I06-1",
"Q8MYF1-1",
"Q8SSV3-1",
"Q9NGW9-1",
"P0CD62-1",
"P34100-1",
"P34102-1",
"P34103-1",
"Q1ZXC8-1",
"Q1ZXH2-1",
"Q1ZXI5-1",
"Q1ZXR2-1",
"Q23915-1",
"Q54HS0-1",
"O61122-1",
"O61125-1",
"P28178-1",
"P34099-1",
"P34101-1",
"P34112-1",
"P34117-1",
"P42525-1",
"P54644-1",
"P54685-1",
"Q02720-1",
"Q1ZXD6-1",
"Q54B33-1",
"Q54B48-1",
"Q54BC9-1",
"Q54BF0-1",
"Q54C18-1",
"Q54C71-1",
"Q54D75-1",
"Q54DC8-1",
"Q54DF2-1",
"Q54DK3-1",
"Q54EG9-1",
"Q54EY4-1",
"Q54GY6-1",
"Q54H45-1",
"Q54H46-1",
"Q54HC6-1",
"Q54I36-1",
"Q54IE8-1",
"Q54JC7-1",
"Q54JG7-1",
"Q54LR6-1",
"Q54M77-1",
"Q54MY9-1",
"Q54P47-1",
"Q54PK9-1",
"Q54Q69-1",
"Q54QB1-1",
"Q54QI2-1",
"Q54QQ1-1",
"Q54QV3-1",
"Q54R82-1",
"Q54RB7-1",
"Q54S77-1",
"Q54T05-1",
"Q54TA1-1",
"Q54TM7-1",
"Q54TW2-1",
"Q54UC0-1",
"Q54UL8-1",
"Q54VD8-1",
"Q54VI1-1",
"Q54W07-1",
"Q54WJ0-1",
"Q54WS5-1",
"Q54WX4-1",
"Q54XL6-1",
"Q54XQ2-1",
"Q54Y26-1",
"Q54YF2-1",
"Q550K8-1",
"Q550L8-1",
"Q551H4-1",
"Q552C6-1",
"Q556Q3-1",
"Q556S2-1",
"Q556Y4-1",
"Q557G1-1",
"Q558U1-1",
"Q55BN8-1",
"Q55CL6-1",
"Q55CY9-1",
"Q55CZ1-1",
"Q55D99-1",
"Q55DD4-1",
"Q55DJ8-1",
"Q55E58-1",
"Q55EC7-1",
"Q55FS2-1",
"Q55FT4-1",
"Q55GJ2-1",
"Q55GV3-1",
"Q5VJL3-1",
"Q6B9X6-1",
"Q6XHA5-1",
"Q6XHB2-1",
"Q75JK0-1",
"Q76NV1-1",
"Q869N2-1",
"Q86AE1-1",
"Q86AT8-1",
"Q86C65-1",
"Q86CS2-1",
"Q86HN7-1",
"Q86IX1-1",
"Q8MVR1-1",
"Q8SSS9-1",
"Q8SSY6-1",
"Q8T2I8-1",
"Q95YH0-1",
"O61267-1",
"P13677-1",
"P23573-1",
"P51123-1",
"Q00168-1",
"Q23977-1",
"Q24210-3",
"Q9VKN7-1",
"O62618-1",
"P10676-1",
"P18431-2",
"P23647-1",
"P52304-1",
"P83098-1",
"P83104-1",
"Q03042-1",
"Q70PP2-1",
"Q8T0S6-1",
"P12370-1",
"Q05652-1",
"Q9VXE5-1",
"P83103-1",
"Q7KRY6-1",
"Q95UN8-1",
"Q8INB9-1",
"A0A0B4KHX7-1",
"A1Z9X0-1",
"P08181-1",
"P11346-1",
"M9PI41-1",
"Q9VM90-1",
"A1ZBL9-1",
"O76324-1",
"P13678-1",
"P16912-1",
"P23572-1",
"P40417-3",
"P48609-1",
"P49071-1",
"P49762-1",
"P54367-1",
"P83099-1",
"P83100-1",
"P83102-1",
"P92208-1",
"Q03043-1",
"Q0KHT7-1",
"Q24324-1",
"Q5EAK6-1",
"Q9NIV1-1",
"Q9VPC0-1",
"Q9VXG8-1",
"Q9W354-1",
"A1Z7T0-1",
"O61443-1",
"O97143-1",
"P05130-1",
"P16911-1",
"P49657-1",
"Q9NI63-1",
"Q9V3Q6-1",
"Q9VA38-1",
"Q9VK45-1",
"Q9W0V1-4",
"P54360-1",
"Q9VT57-1",
"Q9VI13-1",
"A1ZBC4-1",
"Q8IMC6-1",
"Q8IR79-1",
"Q9V3D5-1",
"Q0KHQ5-1",
"Q0KHV6-1",
"Q9NBK5-1",
"Q7PLI7-1",
"X2JAG8-1",
"O61661-1",
"A4VCL2-2",
"A0A0B4KHT3-1",
"A0A4D6K823-1",
"Q9VP22-1",
"Q9VZI2-1",
"Q9W1B0-1",
"Q9V3I5-1",
"A1ZBH7-1",
"Q9W002-1",
"Q9VRJ6-1",
"Q8T9L5-1",
"Q94533-1",
"Q9VUQ9-1",
"Q9VXE3-1",
"Q9VGF9-1",
"Q9VBU2-1",
"Q9VR42-1",
"Q9VW24-1",
"A0A0B4KHC3-1",
"Q9VL34-1",
"Q9VTL5-1",
"Q95TN8-1",
"Q9VCV0-1",
"Q8MSQ4-1",
"Q9VE06-1",
"Q9VJ30-1",
"Q9VXN5-1",
"M9PGC5-1",
"Q9VN23-1",
"M9NGC6-1",
"O61444-1",
"O62602-1",
"Q9VUV4-1",
"Q9VMY8-1",
"Q9VD82-1",
"A0A6M3Q7C8-1",
"Q9W3N8-1",
"Q95SH0-1",
"Q9VJC2-1",
"Q9VI84-1",
"Q9VEN3-1"
],
"evidence": [
{
"id": "46608",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/46608"
}
]
},
{
"id": "R-HSA-2682349",
"name": "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels",
"equation": "",
"summary": "Amiloride-sensitive sodium channels (SCNNs, aka ENaCs, epithelial Na+ channels, non voltage-gated sodium channels) comprises three subunits (alpha, beta and gamma) and plays an essential role in Na+ and fluid absorption in the kidney, colon and lung. The number of channels at the cell's surface (consequently its function) can be regulated. This is achieved by ubiquitination of SCNN via E3 ubiquitin-protein ligases (NED4L and WPP1) (Staub et al. 2000, Farr et al. 2000). NED4L/WPP1 is found in a signaling complex including Raf1 (RAF proto-oncogene serine/threonine-protein kinase), SGK (serum/glucocorticoid-regulated kinase) and GILZ (glucocorticoid-induced leucine zipper protein, TSC22D3) (Soundararajan et al. 2009). Ubiquitinated SCNN (Ub-SCNN) is targeted for degradation so a lesser number of channels are present at the cell surface, reducing the amount of Na+ absorption. Proline-rich sequences at the C-terminus of SCNNs include the PY motif containing a PPxY sequence. PY motifs bind WW domains of NED4L/WPP1. Protein kinases with no lysine K (WNKs) can activate SCNN activity by interacting non-enzymatically with the signaling complex, specifically SGK although the mechanism is unknown (Heise et al. 2010).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [
"R-HSA-2672342"
],
"output_participant_list": [
"R-ALL-947590"
],
"enzyme_list": [
"Q96PU5-1",
"Q9HBY8-2",
"P04049-1",
"Q9BYP7-1",
"Q9H0M0-1",
"O00141-1",
"Q9Y3S1-1",
"Q96J92-1",
"Q9H4A3-1",
"Q96BR1-1"
],
"evidence": [
{
"id": "R-HSA-2682349",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2682349"
}
]
},
{
"id": "R-HSA-392835",
"name": "Rap1 sequesters Raf1 to inhibit ERK cascade",
"equation": "",
"summary": "Active Rap1 binds but does not activate Raf-1, preventing Raf-1 from participating in the Ras/ERK pathway.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P61224-1",
"P62834-1",
"P04049-1"
],
"evidence": [
{
"id": "R-HSA-392835",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392835"
}
]
},
{
"id": "R-HSA-443439",
"name": "c-Src binds Raf1",
"equation": "",
"summary": "c-Src binds to Raf1, the interaction involves the SH2 and SH3 domains of c-Src and requires serine phosphorylation of Raf1. Coexpression of Raf1 and c-Src in Sf9 cells results in c-Src/Raf-1 complexes, tyrosine phosphorylation of Raf-1, and stimulation of Raf-1 kinase activity. Tyr-340 and Tyr-341 were found to be the major tyrosine phosphorylation sites of Raf1 when coexpressed with activated tyrosine kinases. However, the significance of tyrosine phosphorylation under physiological conditions remains unclear, as tyrosine phosphorylation of endogenous Raf-1 following activation has been disputed and may be limited to cells of hematopoietic origin.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1"
],
"evidence": [
{
"id": "R-HSA-443439",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-443439"
}
]
},
{
"id": "R-HSA-443831",
"name": "14-3-3-zeta binds Raf1",
"equation": "",
"summary": "14-3-3 family proteins can bind Raf1 and have been suggested to activate Raf1, but this has been refuted.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1"
],
"evidence": [
{
"id": "R-HSA-443831",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-443831"
}
]
},
{
"id": "R-HSA-5624486",
"name": "SFKs phosphorylates RAF1 on Y340,Y341",
"equation": "",
"summary": "Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P06241-1",
"P04049-1",
"P07948-1",
"P01112-1"
],
"evidence": [
{
"id": "R-HSA-5624486",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5624486"
}
]
},
{
"id": "R-HSA-5624492",
"name": "PAK phosphorylates p21 RAF1 on S338",
"equation": "",
"summary": "RAF regulation is highly complex and is not solely mediated by conformational changes but also requires phosphorylation. Several phosphorylation sites on RAF1 have been identified that are involved in its kinase activity. Two of these phosphorylation sites are serine 338 (S338) and tyrosine 340 and 341 (Y340/341). Gringhuis et al. demonstrated that ManLAM activation of CD209 (DC-SIGN) results in induced phosphorylation of RAF1 on S338 and Y340/341. The phosphorylation of S338 is mediated by p21-activated kinases (PAK). Inhibition of Rho GTPases with toxin B blocks CD209 induced phosphorylation of RAF1on S338 (Gringhuis et al. 2007, Wellbrock et al. 2004).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"Q13153-1",
"Q13177-1",
"P01112-1",
"O75914-1"
],
"evidence": [
{
"id": "R-HSA-5624492",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5624492"
}
]
},
{
"id": "R-HSA-5624494",
"name": "RAF1 binds p21 RAS:GTP",
"equation": "",
"summary": "Upon CLEC7A (Dectin-1) and CD209 (DC-SIGN) activation, RAF1 translocates to the membrane through interaction with the active form of RAS. This interaction induces a conformational change in RAF1 and is required for RAF1 activation (Gringhuis et al. 2007, Wellbrock et al. 2004).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P01112-1"
],
"evidence": [
{
"id": "R-HSA-5624494",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5624494"
}
]
},
{
"id": "R-HSA-5672950",
"name": "Activator\" RAF:YWHAB dimer binds RAS:GTP\"",
"equation": "",
"summary": "Activation of RAS downstream of extracellular signals allows RAS:GTP to recruit BRAF to the plasma membrane, disrupting the pre-existing inactivating interaction between BRAF and the 14-3-3 protein YWHAB (Marais et al, 1997; Yamamori et al, 1995; reviewed in Cseh et al, 2014). BRAF, unique of the three mammalian RAF proteins, is constitutively phosphorylated on the conserved serine residue (446 in BRAF) in the N-terminal acidic motif (NtA). Constitutive negative charge in this region is critical for BRAF to function as an activator of other RAF molecules, allowing signal amplification (Marais et al, 1997; Mason et al, 1999; Wan et al, 2004; Garnett et al, 2005; Hu et al, 2013; reviewed in Cseh et al, 2014). RAS:GTP-bound BRAF heterodimerizes with additional RAF monomers, allowing cis-autophosphorylation in the activation loop of the second RAF protein. Once activated by BRAF in this manner, the 'receiver' kinase monomer is competent to dimerize with and transactivate other monomers in turn (Weber et al, 2001; Garnett et al, 2005; Hu et al, 2013; reviewed in Cseh et al, 2014). Intruigingly, the scaffold protein KSR1 is activated by BRAF in a manner analogous to other RAF monomers and can similarly act as a RAF activator once it is itself activated (Brennan et al, 2011; Ory et al, 2003; reviewed in Raabe and Rapp, 2003; Cseh et al, 2014).
Although this pathway shows PP2A-mediated dephosphorylation of RAF and transient displacement of 14-3-3 proteins as preceding RAS and plasma membrane binding of RAF proteins, the order and dependency of these events is not clear. Both membrane binding and 14-3-3 displacement also appear to be facilitated by an interaction between RAF and the cell cycle protein Prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P01112-1",
"Q8IVT5-1"
],
"evidence": [
{
"id": "R-HSA-5672950",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672950"
}
]
},
{
"id": "R-HSA-5672951",
"name": "Inactive RAFs bind YWHAB",
"equation": "",
"summary": "In quiescent cells, RAF is maintained in a closed state in which the N-terminal regulatory region sterically blocks the catalytic region (Cutler et al, 1998; Tran et al, 2003; Terai et al, 2005; Tran et al, 2005; reviewed in Udell et al, 2011). This closed state is mediated in part by the intramolecular binding of YWHAB/14-3-3 dimers to two phosphorylated serine residues (S259 and S621 in RAF1, S214 and S582 in ARAF and S365 and S729 in BRAF) (Ory et al, 2003; Jaumot et al, 2001; Fischer et al, 2009; reviewed in Udell et al, 2011).
",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1"
],
"evidence": [
{
"id": "R-HSA-5672951",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672951"
}
]
},
{
"id": "R-HSA-5672960",
"name": "YWHAB dimer dissociates from dephosphorylated RAF",
"equation": "",
"summary": "Dephosphorylation of S259 (S365/S214) by PP2A promotes the transient dissociation of 14-3-3 dimers from this site (Ory et al, 2003; Jaumot et al, 2001; Rommel et al, 1996; reviewed in Raabe and Raap, 2003; Matallanas et al, 2011). In the case of RAF1, displacement of 14-3-3 has also been shown to be promoted by a direct interaction between RAF1 and the cell cycle protein prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).
",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1"
],
"evidence": [
{
"id": "R-HSA-5672960",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672960"
}
]
},
{
"id": "R-HSA-5672961",
"name": "PP2A dephosphorylates inactive RAFs",
"equation": "",
"summary": "Upon growth factor stimulation, RAF1 S259 (or S365 and S214 in BRAF and ARAF respectively) is dephosphorylated by PP2A and/or PP1, abrogating one of the YWHAB/14-3-3 binding sites (Terai et al, 2005; Ory et al, 2003; Kubicek et al, 2002; Jaumot et al, 2001; Rommel et al, 1996; reviewed in Roskoski, 2010; Matallanas et al, 2011). Release of 14-3-3 binding from the N-terminal site promotes a conformational change that exposes the membrane and RAS interacting RBD and CRD and facilitates recruitment of RAF to the plasma membrane where it binds RAS:GTP (Kubicek et al, 2002; Goetz et al, 2003; Ory et al, 2003). Dephosphorylation of S259/S365/S214 may also promote dimerization of RAF monomers by replacing the intramolecular 14-3-3 binding interaction with an intermolecular one (Rushworth et al, 2006; Weber et al, 2001; Ritt et al, 2010; reviewed in Matallanas et al, 2011). Although the PP2A-mediated dephosphorylation is shown as occurring before both YWHAB displacement and recruitment of RAF to the plasma membrane, the order of and relationship between these events is not completely clear. In addition, the displacement of 14-3-3 and recruitment of RAF1 to the membrane is also promoted by a direct interaction with cell cycle protein Prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1",
"P67775-1",
"P62714-1"
],
"evidence": [
{
"id": "R-HSA-5672961",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672961"
}
]
},
{
"id": "R-HSA-5672966",
"name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers",
"equation": "",
"summary": "RAF activation depends on the formation of a side-by-side asymmetric homo- or heterodimer (formed from either 2 RAF monomers or a RAF monomer and KSR1) (Weber et al, 2001; Garnett et al, 2005; Rushworth et al, 2006; Rajakulendran et al, 2009; Hu et al, 2013). Dimerization is mediated by cluster of basic residues in the kinase domain, and mutation of these critical residues abrogates RAF activation (Rajakulendran et al, 2009). Dimerization is required for the 'activator' monomer to induce an allosteric change in the 'receiver' monomer that, in conjunction with activation loop phosphorylation, activates the kinase activity of the receiver (Hu et al, 2013). BRAF, by virtue of its constitutive negative charge in the NtA region, is uniquely able to function as an activator RAF without further modification, while RAF1, ARAF and KSR1 can function as activators only after being phosphorylated in the NtA region downstream of RAF pathway activation (Hu et al, 2013; Leicht et al, 2013; reviewed in Cseh et al, 2014). Homo and heterodimerization of RAF monomers may be promoted by association with MAP3K11, which interacts with BRAF and RAF1 in vitro and in vivo and which is required for RAF activation (Chadee et al, 2004a, Chadee et al, 2004b; Chadee et al, 2006).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"Q7Z569-1",
"P01112-1",
"Q8IVT5-1",
"Q16584-1"
],
"evidence": [
{
"id": "R-HSA-5672966",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672966"
}
]
},
{
"id": "R-HSA-5672969",
"name": "Phosphorylation of RAF",
"equation": "",
"summary": "Downstream of RAF dimerization and allosteric activation, RAF monomers and KSR1 undergo a series of activating phosphorylations in both the activation loop (AL) and, in the case of ARAF, RAF1 and KSR1, in the NtA . Phosphorylation of the activation loop residues (T491, S494 in RAF1, T452, T455 in ARAF and T599, S602 in BRAF) contributes to full kinase activity, although this may be less critical for ARAF, and RAFs in general, than for other kinases due to their regulation by 14-3-3 binding (Zhu et al, 2005; Zhang et al, 2000; Baljuls et al, 2008, reviewed in Matallanas et al, 2011; Udell et al, 2011). AL phosphorylation may occur through cis-autophosphorylation within the RAF dimer, although phosphorylation by other kinases is also possible (Hu et al, 2013; reviewed in Matallanas et al, 2011).
Phosphorylation in the RAF NtA region is required for full kinase activity, for interaction with MAP2K substrates and for the ability of activated RAF to act as an allosteric activator of other RAF monomers (Marais et al, 1995; Diaz et al, 1997; Xiang et al, 2002; Edin et al, 2005; Hu et al, 2013; Mason et al, 1999). Phosphorylation of these residues (S338 and Y441 in RAF1, S299 and Y302 in ARAF and Y602 in KSR1) may be mediated by a kinase of the SRC, JAK or PAK family kinases, by MAP2K kinases, calmodulin kinase CaMKII or through autophosphorylation by RAF itself (Marais et al, 1995; Xia et al, 1996; King et al, 1998; Sun et al, 2000; Tran et al, 2003; Tran et al, 2005; Salzano et al. 2012, Hu et al, 2013; reviewed in Matallanas et al, 2011). The phosphorylated NtA of RAF1 is also the binding site for the negative regulator PEPB1, also known as RKIP. PEBP1 binding to RAF1 prevents phosphorylation of the MAP2K substrates (Park et al, 2006; Rath et al, 2008; reviewed in Shin et al, 2009).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"O60674-1",
"Q9UQM7-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"Q13554-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q13557-1",
"Q13555-1"
],
"evidence": [
{
"id": "R-HSA-5672969",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672969"
}
]
},
{
"id": "R-HSA-5672972",
"name": "MAP2Ks and MAPKs bind to the activated RAF complex",
"equation": "",
"summary": "RAF kinases have restricted substrate specificity and have as their primary substrates the two MAP2K proteins MAP2K1 and MAP2K2 (also known as MEK1 and 2). MAP2K1 knockout is embryonic lethal in mice, while MAP2K2 knockouts have no apparent abnormalities, suggesting that MAP2K1 can compensate for MAP2K2 in vivo (Giroux et al, 1999; Belanger et al, 2003). MAP2K proteins exist as stable homo- and heterodimers independent of growth factor stimulation and are generally recruited to activated RAF proteins in conjunction with a scaffolding protein and the MAP2K substrates, MAPK1 and 3 (also known as ERK1 and 2) (Ohren et al, 2004; Catalanotti et al, 2009; Catling et al, 1995; reviewed in Matallanas et al, 2011; Roskoski et al, 2012a; Roskoski et al, 2012b).
Scaffolding proteins promote signaling by providing a docking platform that colocalizes components of the signaling cascade, and provide specificity by controlling the spatial and temporal regulation of the pathway (reviewed in Brown and Sacks, 2009; Matallanas et al, 2011). KSR1 and 2, CNKSR1 and 2, IQGAP1 and the beta arrestins are among the known MAPK scaffold proteins that act at the plasma membrane upon MAPK pathway activation; in addition, paxillin localizes MAPK pathway components to focal adhesion sites in the plasma membrane (Roy et al, 2005; Ren et al, 2007; DeFea et al, 2000; Togho et al, 2003; Ishibe et al, 2003; reviewed in Claperon and Therrien, 2007; Brown and Sacks, 2009; Matallanas et al, 2011). Although this reaction depicts these scaffolding proteins acting equivalently, the details of how they promote pathway activation vary. For instance, KSR1 and 2 are constitutively bound to MAP2K dimers but recruit MAPKs only upon pathway stimulation, while IQGAP1 associates constitutively with both MAP2K and MAPK proteins in unstimulated cells and shows increased interaction with MAP2K1 upon pathway activation by EGF (Stewart et al, 1999; Cacace et al, 2000; Muller et al, 2000; Roy et al, 2004; Roy et al, 2005; reviewed in Brown and Sacks, 2009). Scaffolding complexes may be particularly important for the phosphorylation of cytosolic MAPK targets (reviewed in Casar et al, 2009).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-5672972",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672972"
}
]
},
{
"id": "R-HSA-5672973",
"name": "MAP2Ks phosphorylate MAPKs",
"equation": "",
"summary": "Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-5672973",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672973"
}
]
},
{
"id": "R-HSA-5672978",
"name": "RAF phosphorylates MAP2K dimer",
"equation": "",
"summary": "Activated RAF phosphorylates the MEK kinases MAP2K1 and MAP2K2 on 2 serine residues in the MAP2K activation loop (S218 and S222 in MAP2K1 and S222 and S226 in MAP2K2 (Zheng and Guan, 1994; Alessi et al, 1994; Catling et al, 1995; Papin et al, 1995; Seger et al, 1994; reviewed in Roskoski, 2012a). Although all three RAF kinases can phosphorylate MAP2K1 and MAP2K2, BRAF appears to be the primary activator in vivo (Marais et al, 1997; Jaiswal et al, 1994; Pritchard et al, 1995; reviewed in Welbrock et al, 2004)",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-5672978",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672978"
}
]
},
{
"id": "R-HSA-5672980",
"name": "Dissociation of RAS:RAF complex",
"equation": "",
"summary": "The mechanisms governing the dissociation or trafficking of activated MAPK signaling complexes at the plasma membrane are not fully worked out. Some active complexes may be endocytosed and targeted to other cellular locations, for example the Golgi complex (Lorentzen et al, 2010). Activated RAF monomers may dissociate and homo- or heterodimerize with additional inactive RAF monomers and in this way amplify the signal (reviewed in Matallanas et al, 2011; Cseh et al, 2014).
Ultimately, active RAF complexes are subject to PP5- and PP2A-mediated dephosphorylation, which promotes a return to the inactive state. Hydrolysis of RAS-bound GTP by the intrinsic GTPase activity, stimulated by association with RAS GAP proteins, ultimately promotes dissociation of RAS from RAF allowing a return to the quiescent state (reviewed in Wellbrock et al, 2004; Matallanas et al, 2011).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-5672980",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672980"
}
]
},
{
"id": "R-HSA-5674130",
"name": "MAP2Ks and MAPKs are phosphorylated at the endosome membrane",
"equation": "",
"summary": "Interaction of MAPK pathway components with LAMTOR2, 3 and MORG1 facilitates pathway activation in response to varied stimuli, resulting in the phosphorylation of MAP2K and MAPK proteins at conserved sites in their activation loops (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).",
"cellular_location": "endosome membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P27361-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P28482-1",
"P36507-1",
"Q02750-1"
],
"evidence": [
{
"id": "R-HSA-5674130",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674130"
}
]
},
{
"id": "R-HSA-5674132",
"name": "WDR83:LAMTOR2:LAMTOR3 binds MAPK components",
"equation": "",
"summary": "LAMTOR3 (also known as MEK partner 1, MP1) exists in an obligatory complex with LAMTOR2 (p14) at the endosomal membrane where they act as a scaffold and promote MAPK activation (Schaeffer et al, 1998; Teis et al, 2002; Teis et al, 2006; Sharma et al, 2005). The LAMTOR2/LAMTOR3 complex may also be part of a larger molecular weight complex at the endosome that includes the MAPK organizer protein MORG1 (Vomastek et al, 2004; Sharma et al, 2005; reviewed in Matallanas et al, 2011).",
"cellular_location": "endosome membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P27361-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P28482-1",
"P36507-1",
"Q02750-1"
],
"evidence": [
{
"id": "R-HSA-5674132",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674132"
}
]
},
{
"id": "R-HSA-5674140",
"name": "PAQR3 binds inactive RAFs",
"equation": "",
"summary": "PAQR3, also known as RKTG (Raf kinase trapping to Golgi) is a multi-pass transmembrane protein that binds to RAF1 and BRAF and sequesters them in the Golgi. This inhibits the interaction of RAF with activated RAS and the plasma membrane and inhibits RAF signaling (Feng et al, 2007; Fan et al, 2008; Luo et al, 2008).",
"cellular_location": "Golgi membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1"
],
"evidence": [
{
"id": "R-HSA-5674140",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674140"
}
]
},
{
"id": "R-HSA-5675194",
"name": "Activated MAPK phosphorylates RAF1",
"equation": "",
"summary": "RAF1 is phosphorylated by activated MAPK at 6 serine residues (S29, S43, S289, S296, S301 and S642). MAPK-dependent hyperphosphorylation of RAF1 abrogates the ability of activated RAF1 to interact with RAS and is coincident with inactivation of RAF1. RAF1 proteins containing mutation of these phosphorylation sites persist at the plasma membrane, show sustained S338 phosphorylation and persistent activation relative to WT RAF1 protein. In wild type cells, PP2A and the prolyl-isomerase PIN1 contribute to the dephosphorylation of hyperphosphorylated RAF1, allowing subsequent cycles of activation to occur (Dougherty et al, 2005; reviewed in Roskoski, 2010)",
"cellular_location": "plasma membrane",
"input_participant_list": [
"R-HSA-5672665"
],
"output_participant_list": [
"R-HSA-5675193"
],
"enzyme_list": [
"P27361-1",
"P04049-1",
"P28482-1"
],
"evidence": [
{
"id": "R-HSA-5675194",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675194"
}
]
},
{
"id": "R-HSA-5675417",
"name": "PEBP1 binds activated RAF1",
"equation": "",
"summary": "PEBP1, also known as RKIP (Raf kinase inhibitor protein), is a negative regulator of RAF1 that binds to the phosphorylated NtA region and prevents activation of MAP2K substrates (Yeung et al, 1999; Yeung et al, 2000; Rath et al, 2008; Park et al, 2006; reviewed in Lorenz et al, 2014). Relief of this PEBP1 repression of RAF1 activity is stimulated by phosphorylation of PEBP1, which promotes it dissociation from RAF1. Candidate kinases for phosphorylation of PEBP1 include PKC and the MAPKs themselves, which would establish a positive feedback loop stimulating MAPK pathway activity (Corbit et al, 2003; Cho et al, 2003; Shin et al, 2009).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P01112-1",
"Q8IVT5-1"
],
"evidence": [
{
"id": "R-HSA-5675417",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675417"
}
]
},
{
"id": "R-HSA-5675431",
"name": "PP2A dephosphorylates RAF1",
"equation": "",
"summary": "Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P67775-1",
"P01112-1",
"Q8IVT5-1",
"P62714-1"
],
"evidence": [
{
"id": "R-HSA-5675431",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675431"
}
]
},
{
"id": "R-HSA-5675433",
"name": "PP5 dephosphorylates RAF1 S338",
"equation": "",
"summary": "PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P53041-1",
"P01112-1",
"Q8IVT5-1"
],
"evidence": [
{
"id": "R-HSA-5675433",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675433"
}
]
},
{
"id": "R-HSA-6802908",
"name": "RAS mutants bind inactive RAF",
"equation": "",
"summary": "Downstream of oncogenic RAS, a number of pathways are activated in a cancer- and tissue-specific manner. Common effectors include the PI3K/AKT pathway, the RAL GDS pathway and the canonical RAF/MEK/ERK pathway (reviewed in Prior et al, 2012; Pylayeva-Gupta et al, 2011; Stephen et al, 2014). Activation of the RAF/MEK/ERK pathway depends on the recruitment and activation of RAF downstream of oncogenic RAS, although the extent of pathway activation and the importance of the different RAF genes varies among cancer types. For instance, RAF1 (also known as CRAF) is necessary for onset of RAS-driven non-small cell lung cancer and melanoma, but is dispensable in RAS-driven pancreatic ductal adenocarcinoma (Dumaz et al, 2006; Heidorn et al, 2010; Blasco et al, 2011; Karreth et al, 2011; Eser et al, 2013). And although BRAF activity is not required in RAS-driven melanoma as assessed by siRNA knockdown, in the presence of BRAF inhibitors, BRAF paradoxically contributes to pathway activation through dimerization-dependent activation of RAF1 (Dumaz et al, 2006; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Dumaz, 2011; Lito et al, 2013).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P15056-1",
"P01112-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802908",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802908"
}
]
},
{
"id": "R-HSA-6802912",
"name": "High kinase activity BRAF mutants bind MAP2Ks and MAPKs",
"equation": "",
"summary": "High-kinase activity BRAF mutants such as the prevalent V600E mutant bind MAP2K and MAPK proteins to activate signaling in a constitutive, RAS-independent manner (Wan et al, 2004; Garnett et al, 2005; Ritt et al, 2010; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015). These highly active BRAF mutations are thought to disrupt interactions between the DFG motif and the P loop that are required to hold RAF in the inactive, \\DFG out\\ conformation. In this way, BRAF V600E and other highly active BRAF mutations render the protein constitutively active (Wan et al, 2004; reviewed in Lito et al, 2013; Lavoie and Therrien, 2015). Although highly active BRAF mutants can heterodimerize with and signal through RAF1, V600E BRAF is resistant to disruptions in the dimerization interface, has relaxed requirements for RAF1 activation loop phosphorylation, and is able to signal as a monomer (Garnett et al, 2005; Ritt et al, 2010; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015; Lito et al, 2013).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-6802912",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802912"
}
]
},
{
"id": "R-HSA-6802914",
"name": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs",
"equation": "",
"summary": "RAF dimerization and phosphorylation downstream of moderately activating BRAF mutations is associated with increased MAP2K and MAPK phosphorylation (Wan et al, 2004; Freeman et al, 2013; Roring et al, 2012; reviewed in Holderfield et al, 2014; Lavoie and Therrien, 2015). Although the interactions between oncogenic RAS or RAFs and downstream effectors hasn't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802914",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802914"
}
]
},
{
"id": "R-HSA-6802916",
"name": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants",
"equation": "",
"summary": "Homo- or heterodimerization (with RAF1, also known as CRAF) downstream of moderate kinase activity BRAF mutants leads to phosphorylation and activation of the 'receiver' kinase. Unlike the case for the highly active V600E BRAF mutation, pathway activation downstream of moderately activated BRAF mutants depends both on RAS binding and on dimerization (Wan et al, 2004; Roring et al, 2012; Freeman et al, 2013; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015)
",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"O60674-1",
"Q9UQM7-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"Q13554-1",
"P01112-1",
"P36507-1",
"Q02750-1",
"Q13557-1",
"Q13555-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802916",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802916"
}
]
},
{
"id": "R-HSA-6802918",
"name": "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants",
"equation": "",
"summary": "Downstream of kinase-dead or inhibited forms of BRAF, activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassilliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802918",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802918"
}
]
},
{
"id": "R-HSA-6802919",
"name": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks",
"equation": "",
"summary": "Recruitment of MAP2Ks and MAPKs downstream of moderately activated BRAF mutants leads to phosphorylation and activation of MAP2Ks, as in the WT pathway (Wan et al, 2004; Freeman et al, 2013; Roring et al, 2012; reviewed in Lavoie and Therrien, 2015).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802919",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802919"
}
]
},
{
"id": "R-HSA-6802921",
"name": "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants",
"equation": "",
"summary": "MAPKs are phosphorylated downstream of moderately activated BRAF mutants in a MAP2K-dependent manner (Wan et al, 2004; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802921",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802921"
}
]
},
{
"id": "R-HSA-6802922",
"name": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS",
"equation": "",
"summary": "MAPK proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802922",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802922"
}
]
},
{
"id": "R-HSA-6802924",
"name": "RAF is phosphorylated downstream of oncogenic RAS",
"equation": "",
"summary": "In many cancer types, RAF1 (also known as CRAF) appears to be a critical initial effector of the ERK pathway downstream of activated RAS and also mediates pathway activation in the presence of WT BRAF plus BRAF inhibitors (Rushworth et al, 2006; Dumaz et al, 2006; Garnett et al, 2005; Karreth et al, 2011; Poulikakos et al, 2010; Heidorn et al, 2010; Roring et al, 2012; reviewed in Samatar et al, 2014; Lito et al, 2013). This activation depends largely on heterodimerization with BRAF, although homodimers also contribute (Weber et al, 2001; Rushworth et al, 2006). Activation of RAF downstream of mutant RAS appears to require full phosphorylation of the N-region and the activation loop, unlike the case in BRAF mutant cells, where RAF N-loop phosphorylation is dispensable (Garnett et al, 2005).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"O60674-1",
"Q9UQM7-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"Q13554-1",
"P01112-1",
"P36507-1",
"Q02750-1",
"Q13557-1",
"Q13555-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802924",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802924"
}
]
},
{
"id": "R-HSA-6802925",
"name": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs",
"equation": "",
"summary": "RAF dimerization and phosphorylation downstream of oncogenic RAS and RAF mutations is associated with increased MAP2K and MAPK phosphorylation (Wan et al, 2004; Garnett et al, 2005; reviewed in Holderfield et al, 2014). Although the interactions between oncogenic RAS or RAFs and downstream effectors hasn't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802925",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802925"
}
]
},
{
"id": "R-HSA-6802926",
"name": "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks",
"equation": "",
"summary": "MAP2K proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802926",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802926"
}
]
},
{
"id": "R-HSA-6802927",
"name": "BRAF and RAF fusion mutant dimers are phosphorylated",
"equation": "",
"summary": "Fusion mutants of BRAF and RAF1 are believed to form constitutive dimers and activate downstream signaling independent of RAS and external stimuli (Jones et al, 2008; Cin et al, 2011; Palanisamy et al, 2010; Ciampi et al, 2005; Stransky et al, 2014; Hutchinson et al, 2013; Zhang et al, 2013; Lee et al, 2012; Ricarte-Filho et al, 2013; reviewed in Lavoie and Therrien et al, 2015). The RAF portion of the fusion mutants may undergo phosphorylation of the N-region and activation loops similar to WT as shown in this reaction, although this has not been studied in detail. While WT RAF phosphorylation happens in the context of a complex with with RAS, this is unlikely to be the case for the fusion mutants, as many of these proteins lack the N-terminal RAS binding domain (reviewed in Lavoie and Therrien, 2015).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O15164-1",
"Q6ZMT4-1",
"O60674-1",
"Q9UQM7-1",
"P12931-1",
"Q53H12-1",
"P04049-1",
"P10398-1",
"P15056-1",
"Q13554-1",
"P36507-1",
"Q7KZF4-1",
"Q02750-1",
"Q13557-1",
"Q5XG87-1",
"Q13555-1"
],
"evidence": [
{
"id": "R-HSA-6802927",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802927"
}
]
},
{
"id": "R-HSA-6802934",
"name": "p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs",
"equation": "",
"summary": "BRAF and RAF fusion proteins expressed in cancer constitutively activate downstream signaling and promote cellular transformation (Jones et al, 2008; Cin et al, 2011; Palanisamy et al, 2010; Ciampi et al, 2005; Stransky et al, 2014; Hutchinson et al, 2013; Zhang et al, 2013; Lee et al, 2012; Ricarte-Filho et al, 2013; reviewed in Lavoie and Therrien et al, 2015). Recruitment of MAP2Ks and MAPKs to the fusion dimers may occur in conjunction with scaffold proteins as is the case for WT RAF dimers, however this has not been studied in detail.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"O15164-1",
"Q6ZMT4-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"Q53H12-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q7KZF4-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"Q5XG87-1"
],
"evidence": [
{
"id": "R-HSA-6802934",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802934"
}
]
},
{
"id": "R-HSA-6802941",
"name": "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF",
"equation": "",
"summary": "The enhanced dimerization of inhibited or kinase dead versions of BRAF to RAF1/CRAF stimulates the phosphorylation and transactivation of RAF1 (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015). Other evidence suggests that paradoxical activation of RAF1 by inhibited or inactive BRAF may result from relief of an inhibitory CRAF autophosphorylation event (Holderfield et al, 2013; reviewed in Holderfield, 2014).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"O60674-1",
"Q9UQM7-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"Q13554-1",
"P01112-1",
"P36507-1",
"Q02750-1",
"Q13557-1",
"Q13555-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802941",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802941"
}
]
},
{
"id": "R-HSA-6802942",
"name": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs",
"equation": "",
"summary": "Dimerization of kinase-dead or inhibited versions of BRAF to RAF1/CRAF leads to the recruitment and phosphorylation of MAP2Ks and MAPKs (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015). Although the interactions haven't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802942",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802942"
}
]
},
{
"id": "R-HSA-6802943",
"name": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks",
"equation": "",
"summary": "As in the WT pathway, activation of ERK signaling downstream of kinase-dead or inhibited forms of BRAF depends on phosphorylation of two serine residues in the activation loop of the MAP2K proteins (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6802943",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802943"
}
]
},
{
"id": "R-HSA-6803230",
"name": "Dissociation of moderate activity BRAF complexes",
"equation": "",
"summary": "After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by moderately active BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6803230",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803230"
}
]
},
{
"id": "R-HSA-6803233",
"name": "Dissociation of oncogenic RAS:RAF complex",
"equation": "",
"summary": "After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by oncogenic RAS presumably dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015; Stephen et al, 2014).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6803233",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803233"
}
]
},
{
"id": "R-HSA-6803234",
"name": "Dissociation of paradoxically activated RAS:BRAF complexes",
"equation": "",
"summary": "After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by kinase dead or inhibited BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6803234",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803234"
}
]
},
{
"id": "R-HSA-6803240",
"name": "Homo- or heterodimerization of RAF downstream of mutant RAS",
"equation": "",
"summary": "Similar to the WT pathway, activation of RAF downstream of oncogenic RAS depends on homo- or heterodimerization of RAF, although the importance of RAF proteins varies among cancer types (Dumaz et al, 2006; Heidorn et al, 2010; Blasco et al, 2011; Karreth et al, 2011; Eser et al, 2013; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Lito et al, 2013). A notable exception to this requirement for RAF dimerization is BRAF V600E, which is RAS-independent and constitutively active as a monomer (Roring et al, 2012; Brummer et al, 2006; Freeman et al, 2013; Garnett et al, 2005).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P15056-1",
"P27448-5",
"Q7Z569-1",
"P01112-1",
"Q8IVT5-1",
"Q16584-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-6803240",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803240"
}
]
},
{
"id": "R-HSA-8936676",
"name": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize",
"equation": "",
"summary": "In addition to the prevalent and highly activating V600E mutation, a large number of rare, moderately activating BRAF mutations are also found in human cancers (Wan et al, 2004; Davies et al, 2002). Unlike the V600E mutant, these forms of BRAF require both RAS binding and dimerization to activate MAPK/ERK signaling (Wan et al, 2004; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P15056-1",
"P27448-5",
"Q7Z569-1",
"P01112-1",
"Q8IVT5-1",
"Q16584-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-8936676",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8936676"
}
]
},
{
"id": "R-HSA-8936731",
"name": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1",
"equation": "",
"summary": "The paradoxical activation of ERK signaling downstream of kinase-dead or inhibited forms of BRAF appears to result from enhanced dimerization with RAF1/CRAF (Wan et al, 2004; Poulikakos et al, 2010; Heidorn et al, 2010; Hatzivassilliou et al, 2010; Freeman et al, 2013). The propensity to dimerize may be promoted by conformational changes in the BRAF monomer as a result of mutation or inhibitor binding (reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).
",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P15056-1",
"P27448-5",
"Q7Z569-1",
"P01112-1",
"Q8IVT5-1",
"Q16584-1",
"P01116-1"
],
"evidence": [
{
"id": "R-HSA-8936731",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8936731"
}
]
},
{
"id": "R-HSA-9653108",
"name": "Raf dimer inhibitors bind RAF heterodimers",
"equation": "",
"summary": "LY3009120, TAK-580 and TAK-632 are pan-RAF inhibitors that binds to all 3 RAF isoforms as well as to RAF dimers to inhibit phosphorylation of MAP2K and MAPK proteins (Nakamura et al, 2013; Okaniwa et al, 2013; Sun et al, 2017; Peng et al, 2015; Henry et al, 2015; Vakana et al, 2017). Because they inhibit the kinase activity of RAF homo- and heterodimers, treatment with pan-RAF dimer inhibitors generates minimal paradoxical RAF activation and inhibits cellular proliferation in a number of tumor models (Peng et al, 2015; Henry et al, 2015, Vakana et al, 2017; reviewed in Karoulia et al, 2017; Agianian and Gavathiotis, 2018; ).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P01112-1",
"Q8IVT5-1"
],
"evidence": [
{
"id": "R-HSA-9653108",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9653108"
}
]
},
{
"id": "R-HSA-9656207",
"name": "CR2 RAF1 mutants don't bind YWHAB",
"equation": "",
"summary": "RAF1 mutants have been identified in both RASopathies and various cancers that show elevated levels of signaling through MAP2K and MAPK (Kobayashi et al, 2010; Razzaque et al, 2007; Krauthammer et al, 2015; Pandit et al, 2007; Lee et al, 2011). RAF1 proteins with mutations that cluster in the conserved region 2 (CR2) domain of RAF1 show decreased levels of phosphorylation on S259, which is required for the interaction of RAF1 with the YWHAB 14-3-3 proteins (Kobayashi et al, 2010). Consistent with this CR2 RAF1 mutants show decreased interaction with YWHAB and increased downstream signaling (Kobayashi et al, 2010; Pandit et al, 2007; Lee et al, 2011).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1"
],
"evidence": [
{
"id": "R-HSA-9656207",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656207"
}
]
},
{
"id": "R-HSA-9656209",
"name": "Dissociation of RAS:RAF1 mutant complex",
"equation": "",
"summary": "After phosphorylation of MAPKs by complexes containing RAF1 mutants, activated MAPK signaling complexes dissociate in a manner similar to wildtype, although this has not been explicitly demonstrated in all cases. Active complexes may signal from other cellular locations or may amplify signaling through rounds of heterodimerization with other inactive RAF monomers (reviewed in Matallanas et al, 2011; Cseh et al, 2014).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9656209",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656209"
}
]
},
{
"id": "R-HSA-9656211",
"name": "MAP2Ks and MAPKs bind to the activated mutant RAF1 complex",
"equation": "",
"summary": "MAP2K and MAPK proteins are likely recruited to complexes containing mutant versions of RAF1 proteins, analagous to the wild type pathway, although this has not been explicitly demonstrated in all cases (reviewed in Rauen, 2013).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9656211",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656211"
}
]
},
{
"id": "R-HSA-9656212",
"name": "Phosphorylation of RAF1 mutants",
"equation": "",
"summary": "RAF1 mutants in cancer and germline disorders such as Noonan syndrome undergo enhanced dimerization and activation with BRAF, leading to high levels of downstream signaling. This has been observed even in cases of RAF1 mutations with abrogated or impaired kinase activity (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012; Krauthammer et al, 2015; reviewed in Rauen, 2013).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"O60674-1",
"Q9UQM7-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"Q13554-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q13557-1",
"Q13555-1"
],
"evidence": [
{
"id": "R-HSA-9656212",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656212"
}
]
},
{
"id": "R-HSA-9656213",
"name": "RAF1 mutants show enhanced heterodimerization with BRAF",
"equation": "",
"summary": "Mutations in RAF1 are common in RASopathies such as Noonan Syndrome, Costello Syndrome, LEOPARD Syndrome and others, and also occur at low frequency in some cancers (reviewed in Rauen, 2013; Samatar and Poulikakos, 2014). Germline mutations of RAF1 cluster in three regions: conserved region 2 (CR2) surrounding phosphorylation site S259, the activation segment, or conserved region 3 (CR3). Mutations in CR2 abrogate binding with 14-3-3 proteins and relieve this inhibitory interaction, increasing the downstream signaling presumably through increased availability of RAF1 for heterodimerization with BRAF (Kobayashi et al, 2010; Pandit et al, 2007; Razzaque et al, 2007; Krauthammer et al, 2015). Increased heterodimerization with BRAF has also been demonstrated for RAF1 proteins with mutations in CR3 and the activation domain, including for RAF1 mutants with decreased or absent kinase activity (Pandit et al, 2007; Wu et al, 2012).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P01112-1",
"Q8IVT5-1"
],
"evidence": [
{
"id": "R-HSA-9656213",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656213"
}
]
},
{
"id": "R-HSA-9656214",
"name": "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants",
"equation": "",
"summary": "MAPK proteins are phosphorylated downstream of RAF1 mutants (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9656214",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656214"
}
]
},
{
"id": "R-HSA-9656215",
"name": "RAF1 mutant complexes phosphorylate MAP2K dimer",
"equation": "",
"summary": "MAPK2Ks are phosphorylated downstream of mutant RAF1 proteins (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9656215",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656215"
}
]
},
{
"id": "R-HSA-9657599",
"name": "Dual mechanism MAP2K inhibitors bind MAP2Ks",
"equation": "",
"summary": "Although mutations in MAP2K proteins are infrequent in human cancers, the position of these kinases downstream of RAS and RAF make them good candidates for therapeutic targeting. Dual mechanism inhibitors such as trametinib bind to non-phosphorylated MAP2K proteins, inhibiting their MAPK-directed kinase activity as well as preventing their phosphorylation by RAF proteins (Hatzivassiliou et al, 2013; Lito et al, 2014; Ishii et al, 2013; reviewed in Samatar and Poulikakos, 2014).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9657599",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657599"
}
]
},
{
"id": "R-HSA-9657603",
"name": "Dual mechanism MAPK inhibitors bind MAPKs",
"equation": "",
"summary": "A number of 'dual mechanism' MAPK inhibitors are in preclinical or clinical trials (reviewed in Roskoski, 2019). Dual mechanism inhibitors, including the ATP-competitive inhibitors SCH772984 and MK-8353, bind to the unphosphorylated MAPK and prevent both its own kinase activity and its phosphorylation by MAP2Ks (Morris et al, 2013; Deng et al 2014; Chaikuad et al, 2014; Boga et al, 2018; Moschos et al, 2019; reviewed in Samatar and Poulikakos, 2014). MAPK inhibitors offer the potential to mitigate the development of resistance to RAF and MAP2K inhibitors, which often involves reactivation of MAPK-dependent signaling. As a result, MAPK inhibitors are frequently used in combination with RAF and MAP2K-directed therapeutics (reviewed in Samatar and Poulikakos, 2014; Roskoski, 2019).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9657603",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657603"
}
]
},
{
"id": "R-HSA-9657606",
"name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks",
"equation": "",
"summary": "Single mechanism MAP2K inhibitors bind to phosphorylated forms of MAP2K 1 and 2 and prevent their phosphorylation of MAPK proteins (Hatzivassiliou et al, 2013; reviewed in Samatar and Poulikakos, 2014).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9657606",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657606"
}
]
},
{
"id": "R-HSA-9657608",
"name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK",
"equation": "",
"summary": "Single mechanism MAPK inhibitors such as ulixertinib and ravoxertinib bind to the activated forms of MAPK proteins and inhibit their intrinsic target-directed kinase activity (Germann et al, 2017; Blake et al, 2016; reviewed in Samatar and Poulikakos, 2014).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P01111-1",
"P27361-1",
"P41240-1",
"P61224-1",
"P62834-1",
"P12931-1",
"P04049-1",
"P10398-1",
"P15056-1",
"P27448-5",
"P60709-1",
"P63261-1",
"P28482-1",
"P01112-1",
"P36507-1",
"Q8IVT5-1",
"Q02750-1",
"Q6VAB6-1"
],
"evidence": [
{
"id": "R-HSA-9657608",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657608"
}
]
},
{
"id": "R-HSA-9658445",
"name": "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs",
"equation": "",
"summary": "Activation of RAF upon growth factor stimulation depends on many factors including dephosphorylation, conformational change, dimerization, membrane recruitment and protein-protein interactions, among others (reviewed in Lavoie and Therien, 2015). In the inactive state, RAF1/CRAF is phosphorylated at S259 and S621 (corresponding to S365 and S729 in BRAF, and S214 and S582 in ARAF). These sites mediate the interaction with YWHAB/14-3-3 proteins (reviewed in Matallanas et al, 2011; Lavoie and Therien, 2015). Dephosphorylation of the S259 site by PP2A and or PP1 (also known as PPP1CC) disrupts interaction with 14-3-3 proteins and promotes a conformational change that exposes the membrane and RAS interacting RBD and CRD, facilitating recruitment of RAF to the plasma membrane (Kubicek et al, 2002; Goetz et al, 2003; Ory et al, 2003). PP1-mediated dephosphorylation occurs in the context of a ternary complex consisting of SHOC2 and the RAS protein family member MRAS in its GTP bound form (Rodriguez-Viciano et al, 2006; Young et al, 2013; reviewed in Simanshu et al, 2017). Consistent with a role of this ternary complex in activating RAF signaling, mutations in SHOC2, MRAS and PP1 are associated with increased RAF pathway activity in Noonan syndrome (Cordeddu et al, 2009; Gripp et al, 2016; Higgin et al, 2017; Young et al 2018).
Although S259 dephosphorylation is shown as occurring before both YWHAB displacement and recruitment of RAF to the plasma membrane, the order of and relationship between these events is not completely clear. In addition, the displacement of 14-3-3 and recruitment of RAF1 to the membrane is also promoted by a direct interaction with cell cycle protein Prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1",
"P62140-1",
"P36873-1",
"O14807-1"
],
"evidence": [
{
"id": "R-HSA-9658445",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9658445"
}
]
},
{
"id": "R-HSA-9660536",
"name": "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex",
"equation": "",
"summary": "A loss-of-function mutation in SHOC2 has been identified in a patient with a Noonan-related syndrome (Hannig et al, 2014). SHOC2 M173I has impaired ability to interact with PPP1CC and reduces the MRAS-SHOC2-PP1-dependent dephosphorylation of RAF, which is required for RAF pathway activation (Rodriguez-Viciano et al, 2006; Hannig et al, 2014). How both loss and gain-of-function SHOC2 mutants can contribute to RAF pathway activation remains to be elucidated.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1",
"P62140-1",
"P36873-1",
"O14807-1"
],
"evidence": [
{
"id": "R-HSA-9660536",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660536"
}
]
},
{
"id": "R-HSA-9660538",
"name": "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs",
"equation": "",
"summary": "PP1-mediated dephosphorylation of RAF occurs in the context of a ternary complex consisting of SHOC2 and the RAS protein family member MRAS in its GTP-bound form (Rodriguez-Viciano et al, 2006; Young et al, 2013; reviewed in Simanshu et al, 2017). Consistent with a role of this ternary complex in promoting RAF signaling, activating mutations in SHOC2, MRAS and PP1 are associated with increased RAF pathway activity in Noonan syndrome (Cordeddu et al, 2009; Gripp et al, 2016; Motta et al, 2016; Higgin et al, 2017; Motta et al, 2019a,b; Young et al, 2018).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P04049-1",
"P10398-1",
"P15056-1",
"P62140-1",
"P36873-1",
"O14807-1"
],
"evidence": [
{
"id": "R-HSA-9660538",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660538"
}
]
},
{
"id": "R-HSA-9732729",
"name": "Activated JAK1 binds RAF1",
"equation": "",
"summary": "In response to IFNG (interferon-gamma) stimulation, RAF1 forms a complex with JAK1 in a RAS-independent manner (Sakatsume et al. 1998).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O60674-1",
"P04049-1",
"P23458-1"
],
"evidence": [
{
"id": "R-HSA-9732729",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9732729"
}
]
},
{
"id": "R-HSA-9732738",
"name": "JAK1-mediated phosphorylation of RAF1",
"equation": "",
"summary": "In response to IFNG (interferon-gamma) treatment, JAK1 mediates phosphorylation of RAF1 on an unknown tyrosine residue. As there is direct binding between JAK1 and RAF1, and as JAK1 tyrosine kinase activity is necessary, it is plausible that JAK1 is the tyrosine kinase that acts on RAF1, but indirect JAK1-mediated phosphorylation of RAF1 has not been excluded (Sakatsume et al. 1998).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O60674-1",
"P04049-1",
"P23458-1"
],
"evidence": [
{
"id": "R-HSA-9732738",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9732738"
}
]
},
{
"id": "R-HSA-9732753",
"name": "JAK1-activated RAF1 phosphorylates MAPKs",
"equation": "",
"summary": "RAF1, activated downstream of IFNG (interferon-gamma) in a JAK1-dependent and RAS-independent manner, phosphorylates ERKs: MAPK1 (ERK2) and MAPK3 (ERK1) (Sakatsume et al. 1998). IFNG-mediated activation of ERKs may contribute to transient attenuation of TGF-beta signaling through ERK-mediated phosphorylation of SMAD2 and SMAD3, but a long-term effect depends on IFNG-mediated transcription of SMAD7, an inhibitor of TGF-beta signaling (Ulloa et al. 1999).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P27361-1",
"O60674-1",
"P04049-1",
"P28482-1",
"P23458-1"
],
"evidence": [
{
"id": "R-HSA-9732753",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9732753"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-947590",
"participant_name": "Pi [plasma membrane]",
"crossref": [
{
"id": "C00009",
"database": "COMPOUND",
"url": ""
},
{
"id": "43474",
"database": "ChEBI",
"url": ""
},
{
"id": "C00009",
"database": "COMPOUND",
"url": ""
},
{
"id": "43474",
"database": "ChEBI",
"url": ""
},
{
"id": "C00009",
"database": "COMPOUND",
"url": ""
},
{
"id": "43474",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-HSA-2672342",
"participant_name": "SCNN channels [plasma membrane]",
"crossref": [
{
"id": "CPX-312",
"database": "ComplexPortal",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5672665",
"participant_name": "p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]",
"crossref": [
{
"id": "P04049",
"database": "UniProt",
"url": ""
},
{
"id": "8GFT",
"database": "PDB",
"url": ""
},
{
"id": "3CU8",
"database": "PDB",
"url": ""
},
{
"id": "P04049",
"database": "PRO",
"url": ""
},
{
"id": "6PTS",
"database": "PDB",
"url": ""
},
{
"id": "3OMV",
"database": "PDB",
"url": ""
},
{
"id": "7JHP",
"database": "PDB",
"url": ""
},
{
"id": "3IQJ",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "6PTW",
"database": "PDB",
"url": ""
},
{
"id": "P04049",
"database": "GeneCards",
"url": ""
},
{
"id": "4FJ3",
"database": "PDB",
"url": ""
},
{
"id": "2.7.11.1",
"database": "IntEnz",
"url": ""
},
{
"id": "HMDBP01153",
"database": "HMDB Protein",
"url": ""
},
{
"id": "7Z37",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "XP_011532276.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3IQU",
"database": "PDB",
"url": ""
},
{
"id": "4G0N",
"database": "PDB",
"url": ""
},
{
"id": "XP_005265412.1",
"database": "RefSeq",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "6VJJ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000132155",
"database": "OpenTargets",
"url": ""
},
{
"id": "7Z38",
"database": "PDB",
"url": ""
},
{
"id": "NP_002871.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3IQV",
"database": "PDB",
"url": ""
},
{
"id": "1C1Y",
"database": "PDB",
"url": ""
},
{
"id": "16828",
"database": "Orphanet",
"url": ""
},
{
"id": "4G3X",
"database": "PDB",
"url": ""
},
{
"id": "6XGU",
"database": "PDB",
"url": ""
},
{
"id": "8A68",
"database": "PDB",
"url": ""
},
{
"id": "3KUC",
"database": "PDB",
"url": ""
},
{
"id": "8EPW",
"database": "PDB",
"url": ""
},
{
"id": "P04049",
"database": "ZINC target",
"url": ""
},
{
"id": "6XI7",
"database": "PDB",
"url": ""
},
{
"id": "3O8I",
"database": "PDB",
"url": ""
},
{
"id": "6NTD",
"database": "PDB",
"url": ""
},
{
"id": "8GAE",
"database": "PDB",
"url": ""
},
{
"id": "1RFA",
"database": "PDB",
"url": ""
},
{
"id": "2184",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "8AV0",
"database": "PDB",
"url": ""
},
{
"id": "6XHB",
"database": "PDB",
"url": ""
},
{
"id": "3NKX",
"database": "PDB",
"url": ""
},
{
"id": "6NTC",
"database": "PDB",
"url": ""
},
{
"id": "1GUA",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000508763",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000442415",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000685653",
"database": "Ensembl",
"url": ""
},
{
"id": "8A6H",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000251849",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000691899",
"database": "Ensembl",
"url": ""
},
{
"id": "6XHA",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000132155",
"database": "Ensembl",
"url": ""
},
{
"id": "4IHL",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "ENSG00000132155-RAF1",
"database": "HPA",
"url": ""
},
{
"id": "ENSP00000251849",
"database": "Ensembl",
"url": ""
},
{
"id": "3KUD",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000401888",
"database": "Ensembl",
"url": ""
},
{
"id": "1FAR",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000509968",
"database": "Ensembl",
"url": ""
},
{
"id": "8A6F",
"database": "PDB",
"url": ""
},
{
"id": "6XGV",
"database": "PDB",
"url": ""
},
{
"id": "4IEA",
"database": "PDB",
"url": ""
},
{
"id": "P04049",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "1FAQ",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-5675193",
"participant_name": "hyperphosphorylated RAF1 [plasma membrane]",
"crossref": [
{
"id": "6XGU",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "ENSP00000508763",
"database": "Ensembl",
"url": ""
},
{
"id": "3IQJ",
"database": "PDB",
"url": ""
},
{
"id": "8GAE",
"database": "PDB",
"url": ""
},
{
"id": "4IHL",
"database": "PDB",
"url": ""
},
{
"id": "6VJJ",
"database": "PDB",
"url": ""
},
{
"id": "8A6F",
"database": "PDB",
"url": ""
},
{
"id": "3IQV",
"database": "PDB",
"url": ""
},
{
"id": "3KUD",
"database": "PDB",
"url": ""
},
{
"id": "4FJ3",
"database": "PDB",
"url": ""
},
{
"id": "6XHB",
"database": "PDB",
"url": ""
},
{
"id": "P04049",
"database": "PRO",
"url": ""
},
{
"id": "P04049",
"database": "ZINC target",
"url": ""
},
{
"id": "ENST00000251849",
"database": "Ensembl",
"url": ""
},
{
"id": "4G0N",
"database": "PDB",
"url": ""
},
{
"id": "1FAQ",
"database": "PDB",
"url": ""
},
{
"id": "16828",
"database": "Orphanet",
"url": ""
},
{
"id": "1FAR",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP01153",
"database": "HMDB Protein",
"url": ""
},
{
"id": "6NTC",
"database": "PDB",
"url": ""
},
{
"id": "3OMV",
"database": "PDB",
"url": ""
},
{
"id": "3O8I",
"database": "PDB",
"url": ""
},
{
"id": "6XHA",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "8GFT",
"database": "PDB",
"url": ""
},
{
"id": "2184",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "6PTW",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000132155-RAF1",
"database": "HPA",
"url": ""
},
{
"id": "7Z38",
"database": "PDB",
"url": ""
},
{
"id": "4IEA",
"database": "PDB",
"url": ""
},
{
"id": "3KUC",
"database": "PDB",
"url": ""
},
{
"id": "XP_011532276.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000685653",
"database": "Ensembl",
"url": ""
},
{
"id": "P04049",
"database": "UniProt",
"url": ""
},
{
"id": "6XI7",
"database": "PDB",
"url": ""
},
{
"id": "6PTS",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000691899",
"database": "Ensembl",
"url": ""
},
{
"id": "XP_005265412.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000401888",
"database": "Ensembl",
"url": ""
},
{
"id": "1C1Y",
"database": "PDB",
"url": ""
},
{
"id": "2.7.11.1",
"database": "IntEnz",
"url": ""
},
{
"id": "3NKX",
"database": "PDB",
"url": ""
},
{
"id": "6XGV",
"database": "PDB",
"url": ""
},
{
"id": "8A68",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "ENST00000442415",
"database": "Ensembl",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "1RFA",
"database": "PDB",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "ENSG00000132155",
"database": "OpenTargets",
"url": ""
},
{
"id": "P04049",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "4G3X",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000509968",
"database": "Ensembl",
"url": ""
},
{
"id": "7Z37",
"database": "PDB",
"url": ""
},
{
"id": "1GUA",
"database": "PDB",
"url": ""
},
{
"id": "7JHP",
"database": "PDB",
"url": ""
},
{
"id": "6NTD",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000132155",
"database": "Ensembl",
"url": ""
},
{
"id": "RAF1_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "3CU8",
"database": "PDB",
"url": ""
},
{
"id": "8EPW",
"database": "PDB",
"url": ""
},
{
"id": "8A6H",
"database": "PDB",
"url": ""
},
{
"id": "3IQU",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000251849",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_002871.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P04049",
"database": "GeneCards",
"url": ""
},
{
"id": "8AV0",
"database": "PDB",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "A0A087WRH8",
"gene_name": "Gm5157",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A087WRH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WRH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A087WRH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WRH8"
}
]
}
]
},
{
"uniprot_ac": "A0A087WSA6",
"gene_name": "Gm7358",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A087WSA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WSA6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A087WSA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WSA6"
}
]
}
]
},
{
"uniprot_ac": "A0A087WSF2",
"gene_name": "Smok3c",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A087WSF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WSF2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A087WSF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WSF2"
}
]
}
]
},
{
"uniprot_ac": "A0A0B4J2F2",
"gene_name": "SIK1B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0B4J2F2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4J2F2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0B4J2F2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4J2F2"
}
]
}
]
},
{
"uniprot_ac": "A0A0B4KHC3",
"gene_name": "PKD",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0B4KHC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4KHC3"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "A0A0B4KHC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4KHC3"
}
]
}
]
},
{
"uniprot_ac": "A0A0B4KHT3",
"gene_name": "Lrrk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0B4KHT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4KHT3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0B4KHT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4KHT3"
}
]
}
]
},
{
"uniprot_ac": "A0A0B4KHX7",
"gene_name": "Gcn2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0B4KHX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4KHX7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0B4KHX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0B4KHX7"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2JUP3",
"gene_name": "Obscn",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2JUP3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JUP3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2JUP3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JUP3"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2JVL3",
"gene_name": "Mast3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2JVL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JVL3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2JVL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JVL3"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2JWX7",
"gene_name": "Stk32b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2JWX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JWX7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2JWX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JWX7"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2JXR8",
"gene_name": "LOC100911229",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2JXR8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JXR8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2JXR8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JXR8"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2JZW9",
"gene_name": "ENSRNOG00000068522",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2JZW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JZW9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2JZW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2JZW9"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K2T8",
"gene_name": "RGD1565143",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K2T8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K2T8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2K2T8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K2T8"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K344",
"gene_name": "Pik3ca",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K344",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K344"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "A0A0G2K344",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K344"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "A0A0G2K344",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K344"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "A0A0G2K344",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K344"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "A0A0G2K344",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K344"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K490",
"gene_name": "Tnik",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K490"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2K490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K490"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K578",
"gene_name": "AABR07068650.1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K578",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K578"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2K578",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K578"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K5C7",
"gene_name": "Nek1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K5C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K5C7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2K5C7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K5C7"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K5L3",
"gene_name": "Riok1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K5L3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K5L3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2K5L3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K5L3"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2K6V9",
"gene_name": "RGD1564409",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2K6V9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K6V9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2K6V9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2K6V9"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2KAH6",
"gene_name": "Srpk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2KAH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2KAH6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2KAH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2KAH6"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2KB60",
"gene_name": "Rps6kc1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2KB60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2KB60"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2KB60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2KB60"
}
]
}
]
},
{
"uniprot_ac": "A0A0G2QC55",
"gene_name": "Tssk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A0G2QC55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2QC55"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A0G2QC55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A0G2QC55"
}
]
}
]
},
{
"uniprot_ac": "A0A140LI04",
"gene_name": "Gm5890",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A140LI04",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A140LI04"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A140LI04",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A140LI04"
}
]
}
]
},
{
"uniprot_ac": "A0A140LJ87",
"gene_name": "Gm4565",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A140LJ87",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A140LJ87"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A140LJ87",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A140LJ87"
}
]
}
]
},
{
"uniprot_ac": "A0A3B2WD63",
"gene_name": "Gm7356",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A3B2WD63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A3B2WD63"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A3B2WD63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A3B2WD63"
}
]
}
]
},
{
"uniprot_ac": "A0A4D6K823",
"gene_name": "nmo",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A4D6K823",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A4D6K823"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "A0A4D6K823",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A4D6K823"
}
]
}
]
},
{
"uniprot_ac": "A0A6M3Q7C8",
"gene_name": "SRPK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A6M3Q7C8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A6M3Q7C8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A6M3Q7C8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A6M3Q7C8"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5Y7S3",
"gene_name": "LOC120097771",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5Y7S3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5Y7S3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5Y7S3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5Y7S3"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5Y8C3",
"gene_name": "Stk36",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5Y8C3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5Y8C3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5Y8C3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5Y8C3"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZKJ9",
"gene_name": "ENSRNOG00000070867",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZKJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKJ9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZKJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZKJ9"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZLV4",
"gene_name": "Map4k4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZLV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZLV4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZLV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZLV4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZMP0",
"gene_name": "Mast2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZMP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZMP0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZMP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZMP0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZN46",
"gene_name": "LOC108353138",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZN46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZN46"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZN46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZN46"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZNK2",
"gene_name": "Oxsr1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZNK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZNK2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZNK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZNK2"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZP97",
"gene_name": "Dyrk1b",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZP97",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZP97"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZP97",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZP97"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZR62",
"gene_name": "RGD1565071",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZR62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZR62"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "A0A8I5ZR62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZR62"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZR62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZR62"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZR62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZR62"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZS27",
"gene_name": "LOC102555239",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZS27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZS27"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZS27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZS27"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZSS7",
"gene_name": "LOC102546375",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZSS7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZSS7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZSS7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZSS7"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZT61",
"gene_name": "LOC300308",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZT61",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZT61"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZT61",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZT61"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZUS1",
"gene_name": "Map3k4",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZUS1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZUS1"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZUS1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZUS1"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZUX6",
"gene_name": "RGD1566007",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZUX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZUX6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZUX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZUX6"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZV60",
"gene_name": "Hunk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZV60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZV60"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZV60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZV60"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZYM4",
"gene_name": "Cdk8",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZYM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "A0A8I5ZYM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZYM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZYM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZYM4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I5ZZZ6",
"gene_name": "Riok3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I5ZZZ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I5ZZZ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ6"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A0F8",
"gene_name": "Stk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A0F8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A0F8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A0F8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A0F8"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A165",
"gene_name": "LOC120093114",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A165",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A165"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A165",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A165"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A1U5",
"gene_name": "LOC120093094",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A1U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A1U5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A1U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A1U5"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A574",
"gene_name": "Nek4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A574",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A574"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A574",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A574"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A7D1",
"gene_name": "Rps6ka5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A7D1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A7D1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A7D1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A7D1"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A7V5",
"gene_name": "Cdk14",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A7V5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A7V5"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "A0A8I6A7V5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A7V5"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A8U4",
"gene_name": "ENSRNOG00000066428",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A8U4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A8U4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A8U4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A8U4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6A9X0",
"gene_name": "LOC120100104",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6A9X0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A9X0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6A9X0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A9X0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AAX5",
"gene_name": "LOC120099682",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AAX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AAX5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AAX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AAX5"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6ACE8",
"gene_name": "LOC100910657",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6ACE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ACE8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6ACE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ACE8"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6ACR1",
"gene_name": "ENSRNOG00000067256",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6ACR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ACR1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6ACR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ACR1"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AD01",
"gene_name": "Rps6kl1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AD01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AD01"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AD01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AD01"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AEL0",
"gene_name": "Map3k5",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AEL0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AEL0"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "A0A8I6AEL0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AEL0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AHQ6",
"gene_name": "Nek2l1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AHQ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AHQ6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AHQ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AHQ6"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AJD2",
"gene_name": "LOC103690174",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AJD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AJD2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AJD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AJD2"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AJX5",
"gene_name": "RGD1561440",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AJX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AJX5"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "A0A8I6AJX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AJX5"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6ANX6",
"gene_name": "Dmpk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6ANX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ANX6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6ANX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ANX6"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AQN6",
"gene_name": "Rps6ka6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AQN6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AQN6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AQN6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AQN6"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6ATH0",
"gene_name": "Braf",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6ATH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ATH0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6ATH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ATH0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6ATM1",
"gene_name": "Prkg1",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6ATM1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ATM1"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "A0A8I6ATM1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6ATM1"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AUJ4",
"gene_name": "Mast4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AUJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AUJ4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AUJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AUJ4"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6AWX7",
"gene_name": "Dyrk4",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6AWX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AWX7"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6AWX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6AWX7"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6G1H3",
"gene_name": "Irak4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6G1H3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6G1H3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6G1H3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6G1H3"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6G5Z0",
"gene_name": "AABR07072539.5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6G5Z0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6G5Z0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6G5Z0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6G5Z0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6G980",
"gene_name": "LOC100911984",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6G980",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6G980"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6G980",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6G980"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GBQ0",
"gene_name": "Stk26",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GBQ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GBQ0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GBQ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GBQ0"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GDY5",
"gene_name": "RGD1564651",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GDY5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GDY5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GDY5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GDY5"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GI15",
"gene_name": "RGD1560718",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GI15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GI15"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GI15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GI15"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GJV1",
"gene_name": "ENSRNOG00000069390",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GJV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GJV1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GJV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GJV1"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GK16",
"gene_name": "LOC102549716",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GK16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GK16"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GK16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GK16"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GK52",
"gene_name": "Smg1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GK52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GK52"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GK52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GK52"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GKS8",
"gene_name": "LOC120093063",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GKS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GKS8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GKS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GKS8"
}
]
}
]
},
{
"uniprot_ac": "A0A8I6GM03",
"gene_name": "LOC685793",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8I6GM03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GM03"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8I6GM03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6GM03"
}
]
}
]
},
{
"uniprot_ac": "A0A8J8XEH6",
"gene_name": "ENSRNOG00000067334",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A8J8XEH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8J8XEH6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A8J8XEH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8J8XEH6"
}
]
}
]
},
{
"uniprot_ac": "A0AUV4",
"gene_name": "Gm7168",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0AUV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0AUV4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0AUV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0AUV4"
}
]
}
]
},
{
"uniprot_ac": "A1A5Q6",
"gene_name": "Smok",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A1A5Q6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1A5Q6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A1A5Q6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1A5Q6"
}
]
}
]
},
{
"uniprot_ac": "A1Z7T0",
"gene_name": "Pkn",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A1Z7T0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z7T0"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "A1Z7T0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z7T0"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "A1Z7T0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z7T0"
}
]
}
]
},
{
"uniprot_ac": "A1Z9X0",
"gene_name": "aPKC",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A1Z9X0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z9X0"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "A1Z9X0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1Z9X0"
}
]
}
]
},
{
"uniprot_ac": "A1ZBC4",
"gene_name": "Sik3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A1ZBC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBC4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A1ZBC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBC4"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "A1ZBC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBC4"
}
]
}
]
},
{
"uniprot_ac": "A1ZBH7",
"gene_name": "hppy",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A1ZBH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBH7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A1ZBH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBH7"
}
]
}
]
},
{
"uniprot_ac": "A1ZBL9",
"gene_name": "par-1",
"activity": [
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "A1ZBL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBL9"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "A1ZBL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBL9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A1ZBL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBL9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A1ZBL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A1ZBL9"
}
]
}
]
},
{
"uniprot_ac": "A2AAJ9",
"gene_name": "Obscn",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A2AAJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AAJ9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A2AAJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AAJ9"
}
]
}
]
},
{
"uniprot_ac": "A2AQW0",
"gene_name": "Map3k15",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A2AQW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AQW0"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "A2AQW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AQW0"
}
]
}
]
},
{
"uniprot_ac": "A2AQX6",
"gene_name": "Gm14151",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A2AQX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AQX6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A2AQX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2AQX6"
}
]
}
]
},
{
"uniprot_ac": "A2ASS6",
"gene_name": "Ttn",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A2ASS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2ASS6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A2ASS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2ASS6"
}
]
}
]
},
{
"uniprot_ac": "A2CG49",
"gene_name": "Kalrn",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A2CG49",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2CG49"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A2CG49",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2CG49"
}
]
}
]
},
{
"uniprot_ac": "A2KF29",
"gene_name": "Smoktcr",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A2KF29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2KF29"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A2KF29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A2KF29"
}
]
}
]
},
{
"uniprot_ac": "A4L9P5",
"gene_name": "Hipk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A4L9P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A4L9P5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A4L9P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A4L9P5"
}
]
}
]
},
{
"uniprot_ac": "A4VCL2",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A4VCL2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A4VCL2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A4VCL2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A4VCL2"
}
]
}
]
},
{
"uniprot_ac": "A6HK01",
"gene_name": "Map3k3",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A6HK01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6HK01"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "A6HK01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6HK01"
}
]
}
]
},
{
"uniprot_ac": "A6KB61",
"gene_name": "Riok2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A6KB61",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6KB61"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A6KB61",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A6KB61"
}
]
}
]
},
{
"uniprot_ac": "B0G126",
"gene_name": "pip5k3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B0G126",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G126"
}
]
},
{
"ec_number": "2.7.1.150",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "B0G126",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G126"
}
]
},
{
"ec_number": "2.7.1.150",
"activity": "",
"evidence": [
{
"id": "B0G126",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G126"
}
]
}
]
},
{
"uniprot_ac": "B0LT89",
"gene_name": "Stk24",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B0LT89",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0LT89"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "B0LT89",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0LT89"
}
]
}
]
},
{
"uniprot_ac": "B1WBT4",
"gene_name": "Srpk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B1WBT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B1WBT4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "B1WBT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B1WBT4"
}
]
}
]
},
{
"uniprot_ac": "B1WBU5",
"gene_name": "Sbk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B1WBU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B1WBU5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "B1WBU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B1WBU5"
}
]
}
]
},
{
"uniprot_ac": "B2DD29",
"gene_name": "Brsk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B2DD29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2DD29"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "B2DD29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2DD29"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "B2DD29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2DD29"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "B2DD29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2DD29"
}
]
}
]
},
{
"uniprot_ac": "B2GUY1",
"gene_name": "Plk4",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B2GUY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2GUY1"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "B2GUY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B2GUY1"
}
]
}
]
},
{
"uniprot_ac": "B5DFG1",
"gene_name": "Pink1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "B5DFG1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B5DFG1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "B5DFG1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B5DFG1"
}
]
}
]
},
{
"uniprot_ac": "C0HKC8",
"gene_name": "Smok3a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "C0HKC8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/C0HKC8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "C0HKC8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/C0HKC8"
}
]
}
]
},
{
"uniprot_ac": "C0HKC9",
"gene_name": "Smok3b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "C0HKC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/C0HKC9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "C0HKC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/C0HKC9"
}
]
}
]
},
{
"uniprot_ac": "D3Z822",
"gene_name": "Atr",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3Z822",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z822"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3Z822",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z822"
}
]
}
]
},
{
"uniprot_ac": "D3Z837",
"gene_name": "Cdc42bpg",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3Z837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z837"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3Z837",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z837"
}
]
}
]
},
{
"uniprot_ac": "D3Z8E0",
"gene_name": "Rps6ka3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3Z8E0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z8E0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3Z8E0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z8E0"
}
]
}
]
},
{
"uniprot_ac": "D3Z8I4",
"gene_name": "Map4k1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3Z8I4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z8I4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3Z8I4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3Z8I4"
}
]
}
]
},
{
"uniprot_ac": "D3ZBE5",
"gene_name": "Nek7",
"activity": [
{
"ec_number": "2.7.11.34",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZBE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZBE5"
}
]
},
{
"ec_number": "2.7.11.34",
"activity": "",
"evidence": [
{
"id": "D3ZBE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZBE5"
}
]
}
]
},
{
"uniprot_ac": "D3ZBS8",
"gene_name": "LOC690235",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZBS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZBS8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZBS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZBS8"
}
]
}
]
},
{
"uniprot_ac": "D3ZCD7",
"gene_name": "Tp53rkb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZCD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZCD7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZCD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZCD7"
}
]
}
]
},
{
"uniprot_ac": "D3ZD18",
"gene_name": "Stk32a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZD18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD18"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZD18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZD18"
}
]
}
]
},
{
"uniprot_ac": "D3ZDM6",
"gene_name": "Cdk19",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZDM6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZDM6"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "D3ZDM6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZDM6"
}
]
}
]
},
{
"uniprot_ac": "D3ZEK4",
"gene_name": "Tssk6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZEK4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZEK4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZEK4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZEK4"
}
]
}
]
},
{
"uniprot_ac": "D3ZFL3",
"gene_name": "Map3k6",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZFL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZFL3"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "D3ZFL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZFL3"
}
]
}
]
},
{
"uniprot_ac": "D3ZG83",
"gene_name": "Map3k10",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZG83",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZG83"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "D3ZG83",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZG83"
}
]
}
]
},
{
"uniprot_ac": "D3ZGQ5",
"gene_name": "Nek8",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZGQ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGQ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZGQ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGQ5"
}
]
}
]
},
{
"uniprot_ac": "D3ZHL6",
"gene_name": "Map4k5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZHL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZHL6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZHL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZHL6"
}
]
}
]
},
{
"uniprot_ac": "D3ZHP7",
"gene_name": "Ulk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZHP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZHP7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZHP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZHP7"
}
]
}
]
},
{
"uniprot_ac": "D3ZJ84",
"gene_name": "Tssk5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZJ84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZJ84"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZJ84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZJ84"
}
]
}
]
},
{
"uniprot_ac": "D3ZL21",
"gene_name": "Tp53rka",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZL21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZL21"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZL21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZL21"
}
]
}
]
},
{
"uniprot_ac": "D3ZMG0",
"gene_name": "Ulk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZMG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZMG0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZMG0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZMG0"
}
]
}
]
},
{
"uniprot_ac": "D3ZML2",
"gene_name": "Brsk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZML2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZML2"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "D3ZML2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZML2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZML2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZML2"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "D3ZML2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZML2"
}
]
}
]
},
{
"uniprot_ac": "D3ZQN8",
"gene_name": "Nuak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZQN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZQN8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZQN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZQN8"
}
]
}
]
},
{
"uniprot_ac": "D3ZRJ7",
"gene_name": "Lrrk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZRJ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZRJ7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZRJ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZRJ7"
}
]
}
]
},
{
"uniprot_ac": "D3ZSB7",
"gene_name": "Rps6ka4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZSB7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSB7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZSB7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSB7"
}
]
}
]
},
{
"uniprot_ac": "D3ZSY9",
"gene_name": "Nek5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZSY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSY9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZSY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSY9"
}
]
}
]
},
{
"uniprot_ac": "D3ZSZ3",
"gene_name": "Nlk",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZSZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSZ3"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "D3ZSZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZSZ3"
}
]
}
]
},
{
"uniprot_ac": "D3ZTD1",
"gene_name": "Map3k14",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZTD1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZTD1"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "D3ZTD1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZTD1"
}
]
}
]
},
{
"uniprot_ac": "D3ZXB1",
"gene_name": "Map4k2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZXB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZXB1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZXB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZXB1"
}
]
}
]
},
{
"uniprot_ac": "D3ZY07",
"gene_name": "Plk5",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZY07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZY07"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "D3ZY07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZY07"
}
]
}
]
},
{
"uniprot_ac": "D3ZZK7",
"gene_name": "Myo3a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D3ZZK7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZZK7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D3ZZK7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZZK7"
}
]
}
]
},
{
"uniprot_ac": "D4A229",
"gene_name": "Prkd3",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A229",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A229"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "D4A229",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A229"
}
]
}
]
},
{
"uniprot_ac": "D4A280",
"gene_name": "Pak5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A280"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A280"
}
]
}
]
},
{
"uniprot_ac": "D4A355",
"gene_name": "Mastl",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A355",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A355"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A355",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A355"
}
]
}
]
},
{
"uniprot_ac": "D4A3D9",
"gene_name": "Stk32c",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A3D9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A3D9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A3D9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A3D9"
}
]
}
]
},
{
"uniprot_ac": "D4A3H8",
"gene_name": "Nek11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A3H8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A3H8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A3H8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A3H8"
}
]
}
]
},
{
"uniprot_ac": "D4A454",
"gene_name": "Map3k21",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A454"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "D4A454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A454"
}
]
}
]
},
{
"uniprot_ac": "D4A6T6",
"gene_name": "Melk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A6T6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A6T6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A6T6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A6T6"
}
]
}
]
},
{
"uniprot_ac": "D4A6T9",
"gene_name": "Mark4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A6T9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A6T9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A6T9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A6T9"
}
]
}
]
},
{
"uniprot_ac": "D4A7V9",
"gene_name": "Eif2ak4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A7V9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A7V9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A7V9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A7V9"
}
]
}
]
},
{
"uniprot_ac": "D4A949",
"gene_name": "Smokl1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A949",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A949"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A949",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A949"
}
]
}
]
},
{
"uniprot_ac": "D4A9H8",
"gene_name": "Nim1k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4A9H8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A9H8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4A9H8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4A9H8"
}
]
}
]
},
{
"uniprot_ac": "D4ACL8",
"gene_name": "Atm",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4ACL8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4ACL8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4ACL8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4ACL8"
}
]
}
]
},
{
"uniprot_ac": "D4AD76",
"gene_name": "Aurkc",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4AD76",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AD76"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4AD76",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AD76"
}
]
}
]
},
{
"uniprot_ac": "D4AE24",
"gene_name": "Rps6kb2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4AE24",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AE24"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4AE24",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AE24"
}
]
}
]
},
{
"uniprot_ac": "D4AE59",
"gene_name": "Stk11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "D4AE59",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AE59"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "D4AE59",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D4AE59"
}
]
}
]
},
{
"uniprot_ac": "E9PSK5",
"gene_name": "Sik2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "E9PSK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PSK5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "E9PSK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PSK5"
}
]
}
]
},
{
"uniprot_ac": "E9PSL7",
"gene_name": "Cit",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "E9PSL7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PSL7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "E9PSL7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PSL7"
}
]
}
]
},
{
"uniprot_ac": "E9PSM2",
"gene_name": "LOC301165",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "E9PSM2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PSM2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "E9PSM2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PSM2"
}
]
}
]
},
{
"uniprot_ac": "E9PTG8",
"gene_name": "Stk10",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "E9PTG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PTG8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "E9PTG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9PTG8"
}
]
}
]
},
{
"uniprot_ac": "E9Q3S4",
"gene_name": "Map3k19",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "E9Q3S4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q3S4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "E9Q3S4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/E9Q3S4"
}
]
}
]
},
{
"uniprot_ac": "F1LNJ1",
"gene_name": "Lrrk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LNJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LNJ1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LNJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LNJ1"
}
]
}
]
},
{
"uniprot_ac": "F1LNN8",
"gene_name": "Dapk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LNN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LNN8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LNN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LNN8"
}
]
}
]
},
{
"uniprot_ac": "F1LP90",
"gene_name": "Mink1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LP90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LP90"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LP90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LP90"
}
]
}
]
},
{
"uniprot_ac": "F1LRA7",
"gene_name": "Map3k9",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LRA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LRA7"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "F1LRA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LRA7"
}
]
}
]
},
{
"uniprot_ac": "F1LTP9",
"gene_name": "LOC120093110",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LTP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LTP9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LTP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LTP9"
}
]
}
]
},
{
"uniprot_ac": "F1LUY7",
"gene_name": "Map3k15",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LUY7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LUY7"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "F1LUY7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LUY7"
}
]
}
]
},
{
"uniprot_ac": "F1LWF2",
"gene_name": "Dclk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LWF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LWF2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LWF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LWF2"
}
]
}
]
},
{
"uniprot_ac": "F1LWJ6",
"gene_name": "Myo3b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LWJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LWJ6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LWJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LWJ6"
}
]
}
]
},
{
"uniprot_ac": "F1LXF1",
"gene_name": "Bcr",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LXF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LXF1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1LXF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LXF1"
}
]
}
]
},
{
"uniprot_ac": "F1LYY7",
"gene_name": "Dyrk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1LYY7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LYY7"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "F1LYY7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1LYY7"
}
]
}
]
},
{
"uniprot_ac": "F1M0Z1",
"gene_name": "Trio",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1M0Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M0Z1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1M0Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M0Z1"
}
]
}
]
},
{
"uniprot_ac": "F1M419",
"gene_name": "Pim2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1M419",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M419"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1M419",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M419"
}
]
}
]
},
{
"uniprot_ac": "F1M7G0",
"gene_name": "Trpm6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1M7G0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M7G0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1M7G0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M7G0"
}
]
}
]
},
{
"uniprot_ac": "F1M7N7",
"gene_name": "Rps6ka2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1M7N7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M7N7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "F1M7N7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M7N7"
}
]
}
]
},
{
"uniprot_ac": "F1M7Y5",
"gene_name": "Prkci",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1M7Y5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M7Y5"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "F1M7Y5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M7Y5"
}
]
}
]
},
{
"uniprot_ac": "F1M9D0",
"gene_name": "Map3k2",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F1M9D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M9D0"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "F1M9D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F1M9D0"
}
]
}
]
},
{
"uniprot_ac": "F7FMK8",
"gene_name": "Map3k13",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "F7FMK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F7FMK8"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "F7FMK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/F7FMK8"
}
]
}
]
},
{
"uniprot_ac": "G3V783",
"gene_name": "Ripk2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "G3V783",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V783"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "G3V783",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V783"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "G3V783",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V783"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "G3V783",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/G3V783"
}
]
}
]
},
{
"uniprot_ac": "J3KMT3",
"gene_name": "Gm6882",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "J3KMT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/J3KMT3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "J3KMT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/J3KMT3"
}
]
}
]
},
{
"uniprot_ac": "J3QK59",
"gene_name": "Gm6176",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "J3QK59",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/J3QK59"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "J3QK59",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/J3QK59"
}
]
}
]
},
{
"uniprot_ac": "M0R777",
"gene_name": "LOC102551633",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M0R777",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0R777"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M0R777",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0R777"
}
]
}
]
},
{
"uniprot_ac": "M0R7E7",
"gene_name": "Map2k3",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M0R7E7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0R7E7"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "M0R7E7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0R7E7"
}
]
}
]
},
{
"uniprot_ac": "M0RBT0",
"gene_name": "Haspin",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M0RBT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RBT0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M0RBT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RBT0"
}
]
}
]
},
{
"uniprot_ac": "M0RD40",
"gene_name": "Sik3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M0RD40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RD40"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M0RD40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RD40"
}
]
}
]
},
{
"uniprot_ac": "M0RD88",
"gene_name": "Smok2a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M0RD88",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RD88"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M0RD88",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RD88"
}
]
}
]
},
{
"uniprot_ac": "M0RDM0",
"gene_name": "LOC103689976",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M0RDM0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RDM0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M0RDM0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0RDM0"
}
]
}
]
},
{
"uniprot_ac": "M9NGC6",
"gene_name": "Srpk79D",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M9NGC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M9NGC6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M9NGC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M9NGC6"
}
]
}
]
},
{
"uniprot_ac": "M9PGC5",
"gene_name": "Wnk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M9PGC5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M9PGC5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M9PGC5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M9PGC5"
}
]
}
]
},
{
"uniprot_ac": "M9PI41",
"gene_name": "sti",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "M9PI41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M9PI41"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "M9PI41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M9PI41"
}
]
}
]
},
{
"uniprot_ac": "O00141",
"gene_name": "SGK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O00141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00141"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O00141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00141"
}
]
}
]
},
{
"uniprot_ac": "O00311",
"gene_name": "CDC7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O00311",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00311"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O00311",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00311"
}
]
}
]
},
{
"uniprot_ac": "O00444",
"gene_name": "PLK4",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O00444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00444"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "O00444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00444"
}
]
}
]
},
{
"uniprot_ac": "O00506",
"gene_name": "STK25",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O00506",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00506"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O00506",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00506"
}
]
}
]
},
{
"uniprot_ac": "O08605",
"gene_name": "Mknk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08605",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08605"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O08605",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08605"
}
]
}
]
},
{
"uniprot_ac": "O08648",
"gene_name": "Map3k4",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08648",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08648"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "O08648",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08648"
}
]
}
]
},
{
"uniprot_ac": "O08678",
"gene_name": "Mark1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08678"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O08678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08678"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "O08678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08678"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "O08678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08678"
}
]
}
]
},
{
"uniprot_ac": "O08679",
"gene_name": "Mark2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08679",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08679"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O08679",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08679"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "O08679",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08679"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "O08679",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08679"
}
]
}
]
},
{
"uniprot_ac": "O08815",
"gene_name": "Slk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08815",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08815"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O08815",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08815"
}
]
}
]
},
{
"uniprot_ac": "O08874",
"gene_name": "Pkn2",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08874"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "O08874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08874"
}
]
}
]
},
{
"uniprot_ac": "O08875",
"gene_name": "Dclk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08875",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08875"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O08875",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08875"
}
]
}
]
},
{
"uniprot_ac": "O08901",
"gene_name": "Bub1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08901",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08901"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O08901",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08901"
}
]
}
]
},
{
"uniprot_ac": "O08911",
"gene_name": "Mapk12",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O08911",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08911"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "O08911",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O08911"
}
]
}
]
},
{
"uniprot_ac": "O09110",
"gene_name": "Map2k3",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O09110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09110"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "O09110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O09110"
}
]
}
]
},
{
"uniprot_ac": "O14578",
"gene_name": "CIT",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14578",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14578"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14578",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14578"
}
]
}
]
},
{
"uniprot_ac": "O14730",
"gene_name": "RIOK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14730"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14730"
}
]
}
]
},
{
"uniprot_ac": "O14733",
"gene_name": "MAP2K7",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14733",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14733"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "O14733",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14733"
}
]
}
]
},
{
"uniprot_ac": "O14757",
"gene_name": "CHEK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14757",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14757"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14757",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14757"
}
]
}
]
},
{
"uniprot_ac": "O14807",
"gene_name": "MRAS",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "O14807",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14807"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "O14807",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14807"
}
]
}
]
},
{
"uniprot_ac": "O14874",
"gene_name": "BCKDK",
"activity": [
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "O14874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14874"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14874"
}
]
},
{
"ec_number": "2.7.11.4",
"activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].",
"evidence": [
{
"id": "O14874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14874"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14874"
}
]
}
]
},
{
"uniprot_ac": "O14920",
"gene_name": "IKBKB",
"activity": [
{
"ec_number": "2.7.11.10",
"activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].",
"evidence": [
{
"id": "O14920",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14920"
}
]
},
{
"ec_number": "2.7.11.10",
"activity": "",
"evidence": [
{
"id": "O14920",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14920"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14920",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14920"
}
]
}
]
},
{
"uniprot_ac": "O14936",
"gene_name": "CASK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14936",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14936"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14936",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14936"
}
]
}
]
},
{
"uniprot_ac": "O14965",
"gene_name": "AURKA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14965"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14965"
}
]
}
]
},
{
"uniprot_ac": "O14976",
"gene_name": "GAK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14976"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14976"
}
]
}
]
},
{
"uniprot_ac": "O15021",
"gene_name": "MAST4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O15021",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15021"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O15021",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15021"
}
]
}
]
},
{
"uniprot_ac": "O15075",
"gene_name": "DCLK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O15075",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15075"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O15075",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15075"
}
]
}
]
},
{
"uniprot_ac": "O15164",
"gene_name": "TRIM24",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "O15164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15164"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "O15164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15164"
}
]
}
]
},
{
"uniprot_ac": "O15264",
"gene_name": "MAPK13",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O15264",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15264"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "O15264",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15264"
}
]
}
]
},
{
"uniprot_ac": "O15530",
"gene_name": "PDPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O15530",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15530"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O15530",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15530"
}
]
}
]
},
{
"uniprot_ac": "O35099",
"gene_name": "Map3k5",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35099"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "O35099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35099"
}
]
}
]
},
{
"uniprot_ac": "O35280",
"gene_name": "Chek1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35280"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O35280",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35280"
}
]
}
]
},
{
"uniprot_ac": "O35491",
"gene_name": "Clk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35491"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "O35491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35491"
}
]
}
]
},
{
"uniprot_ac": "O35492",
"gene_name": "Clk3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35492",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35492"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "O35492",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35492"
}
]
}
]
},
{
"uniprot_ac": "O35493",
"gene_name": "Clk4",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35493"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "O35493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35493"
}
]
}
]
},
{
"uniprot_ac": "O35495",
"gene_name": "Cdk14",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35495",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35495"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "O35495",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35495"
}
]
}
]
},
{
"uniprot_ac": "O35831",
"gene_name": "Cdk17",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35831"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "O35831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35831"
}
]
}
]
},
{
"uniprot_ac": "O35832",
"gene_name": "Cdk18",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35832"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "O35832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35832"
}
]
}
]
},
{
"uniprot_ac": "O35942",
"gene_name": "Nek2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O35942",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35942"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O35942",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35942"
}
]
}
]
},
{
"uniprot_ac": "O43283",
"gene_name": "MAP3K13",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43283"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "O43283",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43283"
}
]
}
]
},
{
"uniprot_ac": "O43293",
"gene_name": "DAPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43293",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43293"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O43293",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43293"
}
]
}
]
},
{
"uniprot_ac": "O43318",
"gene_name": "MAP3K7",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43318",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43318"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "O43318",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43318"
}
]
}
]
},
{
"uniprot_ac": "O43353",
"gene_name": "RIPK2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "O43353",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43353"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43353",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43353"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O43353",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43353"
}
]
}
]
},
{
"uniprot_ac": "O43683",
"gene_name": "BUB1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43683"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O43683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43683"
}
]
}
]
},
{
"uniprot_ac": "O43781",
"gene_name": "DYRK3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43781",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43781"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "O43781",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43781"
}
]
}
]
},
{
"uniprot_ac": "O43930",
"gene_name": "PRKY",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O43930",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43930"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O43930",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43930"
}
]
}
]
},
{
"uniprot_ac": "O54748",
"gene_name": "Stk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54748",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54748"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54748",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54748"
}
]
}
]
},
{
"uniprot_ac": "O54781",
"gene_name": "Srpk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54781",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54781"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54781",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54781"
}
]
}
]
},
{
"uniprot_ac": "O54784",
"gene_name": "Dapk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54784"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54784"
}
]
}
]
},
{
"uniprot_ac": "O54785",
"gene_name": "Limk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54785",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54785"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54785",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54785"
}
]
}
]
},
{
"uniprot_ac": "O54833",
"gene_name": "Csnk2a2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54833",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54833"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54833",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54833"
}
]
}
]
},
{
"uniprot_ac": "O54863",
"gene_name": "Tssk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54863",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54863"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54863",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54863"
}
]
}
]
},
{
"uniprot_ac": "O54874",
"gene_name": "Cdc42bpa",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54874"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54874"
}
]
}
]
},
{
"uniprot_ac": "O54949",
"gene_name": "Nlk",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54949",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54949"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "O54949",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54949"
}
]
}
]
},
{
"uniprot_ac": "O54967",
"gene_name": "Tnk2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "O54967",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54967"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "O54967",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54967"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54967",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54967"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54967",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54967"
}
]
}
]
},
{
"uniprot_ac": "O54988",
"gene_name": "Slk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54988",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54988"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54988",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54988"
}
]
}
]
},
{
"uniprot_ac": "O54992",
"gene_name": "Mapkapk5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O54992",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54992"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O54992",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54992"
}
]
}
]
},
{
"uniprot_ac": "O55028",
"gene_name": "Bckdk",
"activity": [
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "O55028",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55028"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O55028",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55028"
}
]
},
{
"ec_number": "2.7.11.4",
"activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].",
"evidence": [
{
"id": "O55028",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55028"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O55028",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55028"
}
]
}
]
},
{
"uniprot_ac": "O55047",
"gene_name": "Tlk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O55047",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55047"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O55047",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55047"
}
]
}
]
},
{
"uniprot_ac": "O55098",
"gene_name": "Stk10",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O55098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55098"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O55098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55098"
}
]
}
]
},
{
"uniprot_ac": "O55099",
"gene_name": "Aurkb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O55099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55099"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O55099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55099"
}
]
}
]
},
{
"uniprot_ac": "O55173",
"gene_name": "Pdpk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O55173",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55173"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O55173",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55173"
}
]
}
]
},
{
"uniprot_ac": "O55222",
"gene_name": "Ilk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O55222",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55222"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O55222",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O55222"
}
]
}
]
},
{
"uniprot_ac": "O60229",
"gene_name": "KALRN",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O60229",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60229"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O60229",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60229"
}
]
}
]
},
{
"uniprot_ac": "O60285",
"gene_name": "NUAK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O60285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60285"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O60285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60285"
}
]
}
]
},
{
"uniprot_ac": "O60307",
"gene_name": "MAST3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O60307",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60307"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O60307",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60307"
}
]
}
]
},
{
"uniprot_ac": "O60566",
"gene_name": "BUB1B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O60566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60566"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O60566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60566"
}
]
}
]
},
{
"uniprot_ac": "O60674",
"gene_name": "JAK2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "O60674",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60674"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "O60674",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60674"
}
]
}
]
},
{
"uniprot_ac": "O61122",
"gene_name": "svkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O61122",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61122"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O61122",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61122"
}
]
}
]
},
{
"uniprot_ac": "O61125",
"gene_name": "krsA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O61125",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61125"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O61125",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61125"
}
]
}
]
},
{
"uniprot_ac": "O61267",
"gene_name": "lok",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O61267",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61267"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O61267",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61267"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "O61267",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61267"
}
]
}
]
},
{
"uniprot_ac": "O61443",
"gene_name": "p38b",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O61443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61443"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "O61443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61443"
}
]
}
]
},
{
"uniprot_ac": "O61444",
"gene_name": "Mkk4",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O61444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61444"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "O61444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61444"
}
]
}
]
},
{
"uniprot_ac": "O61661",
"gene_name": "grp",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O61661",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61661"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O61661",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O61661"
}
]
}
]
},
{
"uniprot_ac": "O62602",
"gene_name": "lic",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O62602",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O62602"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "O62602",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O62602"
}
]
}
]
},
{
"uniprot_ac": "O62618",
"gene_name": "p38a",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O62618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O62618"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "O62618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O62618"
}
]
}
]
},
{
"uniprot_ac": "O70126",
"gene_name": "Aurkb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70126",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70126"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O70126",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70126"
}
]
}
]
},
{
"uniprot_ac": "O70146",
"gene_name": "Tesk1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70146",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70146"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "O70146",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70146"
}
]
}
]
},
{
"uniprot_ac": "O70150",
"gene_name": "Pnck",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70150",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70150"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "O70150",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70150"
}
]
}
]
},
{
"uniprot_ac": "O70405",
"gene_name": "Ulk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70405",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70405"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O70405",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70405"
}
]
}
]
},
{
"uniprot_ac": "O70444",
"gene_name": "Pim3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70444"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O70444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70444"
}
]
}
]
},
{
"uniprot_ac": "O70551",
"gene_name": "Srpk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70551",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70551"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O70551",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70551"
}
]
}
]
},
{
"uniprot_ac": "O70589",
"gene_name": "Cask",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O70589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70589"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O70589",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70589"
}
]
}
]
},
{
"uniprot_ac": "O75116",
"gene_name": "ROCK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75116"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75116"
}
]
}
]
},
{
"uniprot_ac": "O75385",
"gene_name": "ULK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75385",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75385"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75385",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75385"
}
]
}
]
},
{
"uniprot_ac": "O75460",
"gene_name": "ERN1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75460",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75460"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75460",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75460"
}
]
},
{
"ec_number": "3.1.26.-",
"activity": "",
"evidence": [
{
"id": "O75460",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75460"
}
]
}
]
},
{
"uniprot_ac": "O75582",
"gene_name": "RPS6KA5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75582",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75582"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75582",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75582"
}
]
}
]
},
{
"uniprot_ac": "O75676",
"gene_name": "RPS6KA4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75676",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75676"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75676",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75676"
}
]
}
]
},
{
"uniprot_ac": "O75716",
"gene_name": "STK16",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75716",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75716"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75716",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75716"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "O75716",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75716"
}
]
}
]
},
{
"uniprot_ac": "O75914",
"gene_name": "PAK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75914",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75914"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75914",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75914"
}
]
}
]
},
{
"uniprot_ac": "O75962",
"gene_name": "TRIO",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75962",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75962"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75962",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75962"
}
]
}
]
},
{
"uniprot_ac": "O76039",
"gene_name": "CDKL5",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O76039",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76039"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "O76039",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76039"
}
]
}
]
},
{
"uniprot_ac": "O76324",
"gene_name": "dco",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O76324",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76324"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O76324",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76324"
}
]
}
]
},
{
"uniprot_ac": "O88351",
"gene_name": "Ikbkb",
"activity": [
{
"ec_number": "2.7.11.10",
"activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].",
"evidence": [
{
"id": "O88351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88351"
}
]
},
{
"ec_number": "2.7.11.10",
"activity": "",
"evidence": [
{
"id": "O88351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88351"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88351"
}
]
}
]
},
{
"uniprot_ac": "O88445",
"gene_name": "Aurkc",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88445",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88445"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88445",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88445"
}
]
}
]
},
{
"uniprot_ac": "O88506",
"gene_name": "Stk39",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88506",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88506"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88506",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88506"
}
]
}
]
},
{
"uniprot_ac": "O88643",
"gene_name": "Pak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88643",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88643"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88643",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88643"
}
]
}
]
},
{
"uniprot_ac": "O88664",
"gene_name": "Taok1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88664",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88664"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88664",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88664"
}
]
}
]
},
{
"uniprot_ac": "O88697",
"gene_name": "Stk16",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88697",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88697"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88697",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88697"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "O88697",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88697"
}
]
}
]
},
{
"uniprot_ac": "O88764",
"gene_name": "Dapk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88764",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88764"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88764",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88764"
}
]
}
]
},
{
"uniprot_ac": "O88831",
"gene_name": "Camkk2",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88831"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "O88831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88831"
}
]
}
]
},
{
"uniprot_ac": "O88850",
"gene_name": "Hipk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88850",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88850"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88850",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88850"
}
]
}
]
},
{
"uniprot_ac": "O88866",
"gene_name": "Hunk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88866",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88866"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88866",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88866"
}
]
}
]
},
{
"uniprot_ac": "O88904",
"gene_name": "Hipk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O88904",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88904"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O88904",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O88904"
}
]
}
]
},
{
"uniprot_ac": "O94768",
"gene_name": "STK17B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O94768",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94768"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O94768",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94768"
}
]
}
]
},
{
"uniprot_ac": "O94804",
"gene_name": "STK10",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O94804",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94804"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O94804",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94804"
}
]
}
]
},
{
"uniprot_ac": "O94806",
"gene_name": "PRKD3",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O94806",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94806"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "O94806",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94806"
}
]
}
]
},
{
"uniprot_ac": "O94921",
"gene_name": "CDK14",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O94921",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94921"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "O94921",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O94921"
}
]
}
]
},
{
"uniprot_ac": "O95382",
"gene_name": "MAP3K6",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O95382",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95382"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "O95382",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95382"
}
]
}
]
},
{
"uniprot_ac": "O95747",
"gene_name": "OXSR1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O95747",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95747"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O95747",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95747"
}
]
}
]
},
{
"uniprot_ac": "O95819",
"gene_name": "MAP4K4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O95819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95819"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O95819",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95819"
}
]
}
]
},
{
"uniprot_ac": "O95835",
"gene_name": "LATS1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O95835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95835"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O95835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95835"
}
]
}
]
},
{
"uniprot_ac": "O96013",
"gene_name": "PAK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O96013",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O96013"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O96013",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O96013"
}
]
}
]
},
{
"uniprot_ac": "O96017",
"gene_name": "CHEK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O96017",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O96017"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O96017",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O96017"
}
]
}
]
},
{
"uniprot_ac": "O97143",
"gene_name": "SAK",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O97143",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O97143"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "O97143",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O97143"
}
]
}
]
},
{
"uniprot_ac": "P00536",
"gene_name": "Mos",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P00536",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00536"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P00536",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00536"
}
]
}
]
},
{
"uniprot_ac": "P00539",
"gene_name": "Mos",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P00539",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00539"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P00539",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00539"
}
]
}
]
},
{
"uniprot_ac": "P00540",
"gene_name": "MOS",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P00540",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00540"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P00540",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00540"
}
]
}
]
},
{
"uniprot_ac": "P00546",
"gene_name": "CDC28",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P00546",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00546"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P00546",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00546"
}
]
}
]
},
{
"uniprot_ac": "P01111",
"gene_name": "NRAS",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P01111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P01111"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P01111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P01111"
}
]
}
]
},
{
"uniprot_ac": "P01112",
"gene_name": "HRAS",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P01112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P01112"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P01112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P01112"
}
]
}
]
},
{
"uniprot_ac": "P01116",
"gene_name": "KRAS",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P01116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P01116"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P01116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P01116"
}
]
}
]
},
{
"uniprot_ac": "P04049",
"gene_name": "RAF1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P04049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04049"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P04049",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04049"
}
]
}
]
},
{
"uniprot_ac": "P04627",
"gene_name": "Araf",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P04627",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04627"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P04627",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04627"
}
]
}
]
},
{
"uniprot_ac": "P05129",
"gene_name": "PRKCG",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P05129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05129"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P05129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05129"
}
]
}
]
},
{
"uniprot_ac": "P05130",
"gene_name": "Pkc53E",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P05130",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05130"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P05130",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05130"
}
]
}
]
},
{
"uniprot_ac": "P05132",
"gene_name": "Prkaca",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P05132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05132"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P05132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05132"
}
]
}
]
},
{
"uniprot_ac": "P05696",
"gene_name": "Prkca",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P05696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05696"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P05696",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05696"
}
]
}
]
},
{
"uniprot_ac": "P05771",
"gene_name": "PRKCB",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P05771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05771"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P05771",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05771"
}
]
}
]
},
{
"uniprot_ac": "P05986",
"gene_name": "TPK3",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P05986",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05986"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P05986",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P05986"
}
]
}
]
},
{
"uniprot_ac": "P06241",
"gene_name": "FYN",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P06241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06241"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P06241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06241"
}
]
}
]
},
{
"uniprot_ac": "P06243",
"gene_name": "CDC7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06243",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06243"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P06243",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06243"
}
]
}
]
},
{
"uniprot_ac": "P06244",
"gene_name": "TPK1",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06244",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06244"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P06244",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06244"
}
]
}
]
},
{
"uniprot_ac": "P06245",
"gene_name": "TPK2",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06245",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06245"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P06245",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06245"
}
]
}
]
},
{
"uniprot_ac": "P06493",
"gene_name": "CDK1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P06493",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06493"
}
]
}
]
},
{
"uniprot_ac": "P06782",
"gene_name": "SNF1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06782",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06782"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P06782",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06782"
}
]
}
]
},
{
"uniprot_ac": "P06784",
"gene_name": "STE7",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06784"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P06784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06784"
}
]
}
]
},
{
"uniprot_ac": "P06803",
"gene_name": "Pim1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P06803",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06803"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P06803",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06803"
}
]
}
]
},
{
"uniprot_ac": "P07934",
"gene_name": "Phkg1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P07934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07934"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P07934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07934"
}
]
},
{
"ec_number": "2.7.11.19",
"activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.",
"evidence": [
{
"id": "P07934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07934"
}
]
},
{
"ec_number": "2.7.11.19",
"activity": "",
"evidence": [
{
"id": "P07934",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07934"
}
]
}
]
},
{
"uniprot_ac": "P07948",
"gene_name": "LYN",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P07948",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07948"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P07948",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07948"
}
]
}
]
},
{
"uniprot_ac": "P08018",
"gene_name": "PBS2",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P08018",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08018"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P08018",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08018"
}
]
}
]
},
{
"uniprot_ac": "P08181",
"gene_name": "CkIIalpha",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P08181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08181"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P08181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08181"
}
]
}
]
},
{
"uniprot_ac": "P08413",
"gene_name": "Camk2b",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P08413",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08413"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P08413",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08413"
}
]
}
]
},
{
"uniprot_ac": "P08414",
"gene_name": "Camk4",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P08414",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08414"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P08414",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08414"
}
]
}
]
},
{
"uniprot_ac": "P08458",
"gene_name": "SPS1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P08458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08458"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P08458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08458"
}
]
}
]
},
{
"uniprot_ac": "P09215",
"gene_name": "Prkcd",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P09215",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09215"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P09215",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09215"
}
]
}
]
},
{
"uniprot_ac": "P09216",
"gene_name": "Prkce",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P09216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09216"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P09216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09216"
}
]
}
]
},
{
"uniprot_ac": "P09217",
"gene_name": "Prkcz",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P09217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09217"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P09217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09217"
}
]
}
]
},
{
"uniprot_ac": "P0C0R5",
"gene_name": "Pik3r4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C0R5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C0R5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0C0R5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C0R5"
}
]
}
]
},
{
"uniprot_ac": "P0C1X8",
"gene_name": "Aak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C1X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1X8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0C1X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1X8"
}
]
}
]
},
{
"uniprot_ac": "P0C263",
"gene_name": "SBK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C263",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C263"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0C263",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C263"
}
]
}
]
},
{
"uniprot_ac": "P0C264",
"gene_name": "SBK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C264",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C264"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0C264",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C264"
}
]
}
]
},
{
"uniprot_ac": "P0C5K0",
"gene_name": "Sbk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C5K0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C5K0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0C5K0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C5K0"
}
]
}
]
},
{
"uniprot_ac": "P0C5K1",
"gene_name": "Sbk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C5K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C5K1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0C5K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C5K1"
}
]
}
]
},
{
"uniprot_ac": "P0C605",
"gene_name": "Prkg1",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C605",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C605"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "P0C605",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C605"
}
]
}
]
},
{
"uniprot_ac": "P0C865",
"gene_name": "Mapk7",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C865",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C865"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P0C865",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C865"
}
]
}
]
},
{
"uniprot_ac": "P0C8E4",
"gene_name": "Map3k7",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0C8E4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C8E4"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P0C8E4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C8E4"
}
]
}
]
},
{
"uniprot_ac": "P0CD62",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P0CD62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CD62"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P0CD62",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0CD62"
}
]
}
]
},
{
"uniprot_ac": "P10398",
"gene_name": "ARAF",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P10398",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10398"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P10398",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10398"
}
]
}
]
},
{
"uniprot_ac": "P10676",
"gene_name": "ninaC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P10676",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10676"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P10676",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P10676"
}
]
}
]
},
{
"uniprot_ac": "P11274",
"gene_name": "BCR",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11274",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11274"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P11274",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11274"
}
]
}
]
},
{
"uniprot_ac": "P11275",
"gene_name": "Camk2a",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11275",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11275"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P11275",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11275"
}
]
}
]
},
{
"uniprot_ac": "P11309",
"gene_name": "PIM1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11309",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11309"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P11309",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11309"
}
]
}
]
},
{
"uniprot_ac": "P11345",
"gene_name": "Raf1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11345",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11345"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P11345",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11345"
}
]
}
]
},
{
"uniprot_ac": "P11346",
"gene_name": "Raf",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11346",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11346"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P11346",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11346"
}
]
}
]
},
{
"uniprot_ac": "P11440",
"gene_name": "Cdk1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11440",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11440"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P11440",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11440"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P11440",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11440"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P11440",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11440"
}
]
}
]
},
{
"uniprot_ac": "P11730",
"gene_name": "Camk2g",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11730"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P11730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11730"
}
]
}
]
},
{
"uniprot_ac": "P11792",
"gene_name": "SCH9",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11792",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11792"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P11792",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11792"
}
]
}
]
},
{
"uniprot_ac": "P11798",
"gene_name": "Camk2a",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11798"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P11798",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11798"
}
]
}
]
},
{
"uniprot_ac": "P11801",
"gene_name": "PSKH1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11801"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P11801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11801"
}
]
}
]
},
{
"uniprot_ac": "P11802",
"gene_name": "CDK4",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11802",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11802"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P11802",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11802"
}
]
}
]
},
{
"uniprot_ac": "P11980",
"gene_name": "Pkm",
"activity": [
{
"ec_number": "2.7.1.40",
"activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.",
"evidence": [
{
"id": "P11980",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11980"
}
]
},
{
"ec_number": "2.7.1.40",
"activity": "",
"evidence": [
{
"id": "P11980",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11980"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P11980",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11980"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P11980",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11980"
}
]
}
]
},
{
"uniprot_ac": "P12370",
"gene_name": "Pka-C1",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P12370",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12370"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P12370",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12370"
}
]
}
]
},
{
"uniprot_ac": "P12688",
"gene_name": "YPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P12688",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12688"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P12688",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12688"
}
]
}
]
},
{
"uniprot_ac": "P12931",
"gene_name": "SRC",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P12931",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12931"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P12931",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12931"
}
]
}
]
},
{
"uniprot_ac": "P13185",
"gene_name": "KIN1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P13185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13185"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P13185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13185"
}
]
}
]
},
{
"uniprot_ac": "P13186",
"gene_name": "KIN2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P13186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13186"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P13186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13186"
}
]
}
]
},
{
"uniprot_ac": "P13234",
"gene_name": "Camk4",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P13234",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13234"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P13234",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13234"
}
]
}
]
},
{
"uniprot_ac": "P13286",
"gene_name": "Phkg1",
"activity": [
{
"ec_number": "2.7.11.19",
"activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.",
"evidence": [
{
"id": "P13286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13286"
}
]
},
{
"ec_number": "2.7.11.19",
"activity": "",
"evidence": [
{
"id": "P13286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13286"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P13286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13286"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P13286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13286"
}
]
}
]
},
{
"uniprot_ac": "P13677",
"gene_name": "inaC",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P13677",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13677"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P13677",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13677"
}
]
}
]
},
{
"uniprot_ac": "P13678",
"gene_name": "Pkc98E",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P13678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13678"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P13678",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13678"
}
]
}
]
},
{
"uniprot_ac": "P14056",
"gene_name": "Araf",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P14056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14056"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P14056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14056"
}
]
}
]
},
{
"uniprot_ac": "P14618",
"gene_name": "PKM",
"activity": [
{
"ec_number": "2.7.1.40",
"activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
},
{
"ec_number": "2.7.1.40",
"activity": "",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P14618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14618"
}
]
}
]
},
{
"uniprot_ac": "P14680",
"gene_name": "YAK1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P14680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14680"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P14680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14680"
}
]
}
]
},
{
"uniprot_ac": "P14681",
"gene_name": "KSS1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P14681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14681"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P14681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P14681"
}
]
}
]
},
{
"uniprot_ac": "P15056",
"gene_name": "BRAF",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P15056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15056"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P15056",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15056"
}
]
}
]
},
{
"uniprot_ac": "P15442",
"gene_name": "GCN2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P15442",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15442"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P15442",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15442"
}
]
}
]
},
{
"uniprot_ac": "P15790",
"gene_name": "CKA1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P15790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15790"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P15790",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15790"
}
]
}
]
},
{
"uniprot_ac": "P15791",
"gene_name": "Camk2d",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P15791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15791"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P15791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P15791"
}
]
}
]
},
{
"uniprot_ac": "P16054",
"gene_name": "Prkce",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P16054",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16054"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P16054",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16054"
}
]
}
]
},
{
"uniprot_ac": "P16892",
"gene_name": "FUS3",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P16892",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16892"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P16892",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16892"
}
]
}
]
},
{
"uniprot_ac": "P16911",
"gene_name": "Pka-C2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P16911",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16911"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P16911",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16911"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P16911",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16911"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "P16911",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16911"
}
]
}
]
},
{
"uniprot_ac": "P16912",
"gene_name": "Pka-C3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P16912",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16912"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P16912",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16912"
}
]
}
]
},
{
"uniprot_ac": "P17157",
"gene_name": "PHO85",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P17157",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17157"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P17157",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17157"
}
]
}
]
},
{
"uniprot_ac": "P17252",
"gene_name": "PRKCA",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P17252",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17252"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P17252",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17252"
}
]
}
]
},
{
"uniprot_ac": "P17612",
"gene_name": "PRKACA",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P17612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17612"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P17612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P17612"
}
]
}
]
},
{
"uniprot_ac": "P18265",
"gene_name": "Gsk3a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P18265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18265"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P18265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18265"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "P18265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18265"
}
]
}
]
},
{
"uniprot_ac": "P18266",
"gene_name": "Gsk3b",
"activity": [
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P18266",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18266"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "P18266",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18266"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P18266",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18266"
}
]
}
]
},
{
"uniprot_ac": "P18431",
"gene_name": "sgg",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P18431",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18431"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P18431",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18431"
}
]
}
]
},
{
"uniprot_ac": "P18653",
"gene_name": "Rps6ka1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P18653",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18653"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P18653",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18653"
}
]
}
]
},
{
"uniprot_ac": "P18654",
"gene_name": "Rps6ka3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P18654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18654"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P18654",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18654"
}
]
}
]
},
{
"uniprot_ac": "P18961",
"gene_name": "YPK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P18961",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18961"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P18961",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P18961"
}
]
}
]
},
{
"uniprot_ac": "P19139",
"gene_name": "Csnk2a1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P19139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19139"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P19139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19139"
}
]
}
]
},
{
"uniprot_ac": "P19454",
"gene_name": "CKA2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P19454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19454"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P19454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19454"
}
]
}
]
},
{
"uniprot_ac": "P19525",
"gene_name": "EIF2AK2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P19525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19525"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P19525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19525"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P19525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19525"
}
]
}
]
},
{
"uniprot_ac": "P19784",
"gene_name": "CSNK2A2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P19784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19784"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P19784",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19784"
}
]
}
]
},
{
"uniprot_ac": "P20444",
"gene_name": "Prkca",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P20444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20444"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P20444",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20444"
}
]
}
]
},
{
"uniprot_ac": "P20793",
"gene_name": "Mak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P20793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20793"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P20793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20793"
}
]
}
]
},
{
"uniprot_ac": "P20794",
"gene_name": "MAK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P20794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20794"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P20794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P20794"
}
]
}
]
},
{
"uniprot_ac": "P21127",
"gene_name": "CDK11B",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P21127",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21127"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P21127",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21127"
}
]
}
]
},
{
"uniprot_ac": "P21675",
"gene_name": "TAF1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P21675",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21675"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].",
"evidence": [
{
"id": "P21675",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21675"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P21675",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21675"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "",
"evidence": [
{
"id": "P21675",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21675"
}
]
}
]
},
{
"uniprot_ac": "P21708",
"gene_name": "Mapk3",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P21708",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21708"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P21708",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21708"
}
]
}
]
},
{
"uniprot_ac": "P21965",
"gene_name": "MCK1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P21965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21965"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P21965",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P21965"
}
]
}
]
},
{
"uniprot_ac": "P22204",
"gene_name": "DBF2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22204",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22204"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P22204",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22204"
}
]
}
]
},
{
"uniprot_ac": "P22209",
"gene_name": "KIN3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22209",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22209"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P22209",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22209"
}
]
}
]
},
{
"uniprot_ac": "P22211",
"gene_name": "NPR1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22211",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22211"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P22211",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22211"
}
]
}
]
},
{
"uniprot_ac": "P22216",
"gene_name": "RAD53",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22216"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P22216",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22216"
}
]
}
]
},
{
"uniprot_ac": "P22219",
"gene_name": "VPS15",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22219",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22219"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P22219",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22219"
}
]
}
]
},
{
"uniprot_ac": "P22517",
"gene_name": "CMK2",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22517",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22517"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P22517",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22517"
}
]
}
]
},
{
"uniprot_ac": "P22518",
"gene_name": "Clk1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22518",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22518"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P22518",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22518"
}
]
}
]
},
{
"uniprot_ac": "P22612",
"gene_name": "PRKACG",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22612"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P22612",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22612"
}
]
}
]
},
{
"uniprot_ac": "P22694",
"gene_name": "PRKACB",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P22694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22694"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P22694",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22694"
}
]
}
]
},
{
"uniprot_ac": "P23291",
"gene_name": "YCK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23291"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P23291",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23291"
}
]
}
]
},
{
"uniprot_ac": "P23292",
"gene_name": "YCK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23292",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23292"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P23292",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23292"
}
]
}
]
},
{
"uniprot_ac": "P23293",
"gene_name": "SGV1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23293",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23293"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P23293",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23293"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P23293",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23293"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P23293",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23293"
}
]
}
]
},
{
"uniprot_ac": "P23298",
"gene_name": "Prkch",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23298",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23298"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P23298",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23298"
}
]
}
]
},
{
"uniprot_ac": "P23443",
"gene_name": "RPS6KB1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23443"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P23443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23443"
}
]
}
]
},
{
"uniprot_ac": "P23458",
"gene_name": "JAK1",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P23458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23458"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P23458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23458"
}
]
}
]
},
{
"uniprot_ac": "P23561",
"gene_name": "STE11",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23561",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23561"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P23561",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23561"
}
]
}
]
},
{
"uniprot_ac": "P23572",
"gene_name": "Cdk1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23572"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P23572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23572"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P23572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23572"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P23572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23572"
}
]
}
]
},
{
"uniprot_ac": "P23573",
"gene_name": "Cdk2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23573"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P23573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23573"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P23573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23573"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P23573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23573"
}
]
}
]
},
{
"uniprot_ac": "P23647",
"gene_name": "fu",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P23647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23647"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P23647",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23647"
}
]
}
]
},
{
"uniprot_ac": "P24583",
"gene_name": "PKC1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24583"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P24583",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24583"
}
]
}
]
},
{
"uniprot_ac": "P24719",
"gene_name": "MEK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24719",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24719"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P24719",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24719"
}
]
}
]
},
{
"uniprot_ac": "P24723",
"gene_name": "PRKCH",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24723",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24723"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P24723",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24723"
}
]
}
]
},
{
"uniprot_ac": "P24788",
"gene_name": "Cdk11b",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24788",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24788"
}
]
}
]
},
{
"uniprot_ac": "P24941",
"gene_name": "CDK2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P24941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24941"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P24941",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P24941"
}
]
}
]
},
{
"uniprot_ac": "P25333",
"gene_name": "SAT4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P25333",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25333"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P25333",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25333"
}
]
}
]
},
{
"uniprot_ac": "P25341",
"gene_name": "KIN82",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P25341",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25341"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P25341",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25341"
}
]
}
]
},
{
"uniprot_ac": "P25389",
"gene_name": "KCC4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P25389",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25389"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P25389",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25389"
}
]
}
]
},
{
"uniprot_ac": "P25390",
"gene_name": "SSK22",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P25390",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25390"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P25390",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P25390"
}
]
}
]
},
{
"uniprot_ac": "P26794",
"gene_name": "Pim1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P26794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26794"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P26794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P26794"
}
]
}
]
},
{
"uniprot_ac": "P27361",
"gene_name": "MAPK3",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P27361",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27361"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P27361",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27361"
}
]
}
]
},
{
"uniprot_ac": "P27448",
"gene_name": "MARK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P27448",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27448"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P27448",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27448"
}
]
}
]
},
{
"uniprot_ac": "P27466",
"gene_name": "CMK1",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P27466",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27466"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P27466",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27466"
}
]
}
]
},
{
"uniprot_ac": "P27636",
"gene_name": "CDC15",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P27636",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27636"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P27636",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27636"
}
]
}
]
},
{
"uniprot_ac": "P27704",
"gene_name": "Mapk6",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P27704",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27704"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P27704",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27704"
}
]
}
]
},
{
"uniprot_ac": "P27791",
"gene_name": "Prkaca",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P27791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27791"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P27791",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P27791"
}
]
}
]
},
{
"uniprot_ac": "P28028",
"gene_name": "Braf",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28028",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28028"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P28028",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28028"
}
]
}
]
},
{
"uniprot_ac": "P28178",
"gene_name": "pkgB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28178"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P28178",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28178"
}
]
}
]
},
{
"uniprot_ac": "P28482",
"gene_name": "MAPK1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28482",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28482"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P28482",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28482"
}
]
}
]
},
{
"uniprot_ac": "P28652",
"gene_name": "Camk2b",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28652",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28652"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P28652",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28652"
}
]
}
]
},
{
"uniprot_ac": "P28708",
"gene_name": "PRR1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28708",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28708"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P28708",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28708"
}
]
}
]
},
{
"uniprot_ac": "P28867",
"gene_name": "Prkcd",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P28867",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28867"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P28867",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28867"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P28867",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P28867"
}
]
}
]
},
{
"uniprot_ac": "P29295",
"gene_name": "HRR25",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P29295",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29295"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P29295",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29295"
}
]
}
]
},
{
"uniprot_ac": "P30285",
"gene_name": "Cdk4",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P30285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30285"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P30285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P30285"
}
]
}
]
},
{
"uniprot_ac": "P31152",
"gene_name": "MAPK4",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P31152",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31152"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P31152",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31152"
}
]
}
]
},
{
"uniprot_ac": "P31374",
"gene_name": "PSK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P31374",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31374"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P31374",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31374"
}
]
}
]
},
{
"uniprot_ac": "P31749",
"gene_name": "AKT1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P31749",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31749"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P31749",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31749"
}
]
}
]
},
{
"uniprot_ac": "P31750",
"gene_name": "Akt1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P31750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31750"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P31750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31750"
}
]
}
]
},
{
"uniprot_ac": "P31751",
"gene_name": "AKT2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P31751",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31751"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P31751",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31751"
}
]
}
]
},
{
"uniprot_ac": "P31938",
"gene_name": "Map2k1",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P31938",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31938"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P31938",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P31938"
}
]
}
]
},
{
"uniprot_ac": "P32328",
"gene_name": "DBF20",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32328",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32328"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P32328",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32328"
}
]
}
]
},
{
"uniprot_ac": "P32350",
"gene_name": "KNS1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32350"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P32350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32350"
}
]
}
]
},
{
"uniprot_ac": "P32361",
"gene_name": "IRE1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32361",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32361"
}
]
},
{
"ec_number": "3.1.26.-",
"activity": "",
"evidence": [
{
"id": "P32361",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32361"
}
]
}
]
},
{
"uniprot_ac": "P32485",
"gene_name": "HOG1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32485",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32485"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P32485",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32485"
}
]
}
]
},
{
"uniprot_ac": "P32490",
"gene_name": "MKK1",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32490"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P32490",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32490"
}
]
}
]
},
{
"uniprot_ac": "P32491",
"gene_name": "MKK2",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32491"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P32491",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32491"
}
]
}
]
},
{
"uniprot_ac": "P32562",
"gene_name": "CDC5",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32562"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "P32562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32562"
}
]
}
]
},
{
"uniprot_ac": "P32581",
"gene_name": "IME2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32581"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P32581",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32581"
}
]
}
]
},
{
"uniprot_ac": "P32600",
"gene_name": "TOR2",
"activity": [
{
"ec_number": "2.7.1.67",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P32600",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32600"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32600",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32600"
}
]
},
{
"ec_number": "2.7.1.67",
"activity": "",
"evidence": [
{
"id": "P32600",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32600"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P32600",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32600"
}
]
}
]
},
{
"uniprot_ac": "P32789",
"gene_name": "ALK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32789",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32789"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P32789",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32789"
}
]
}
]
},
{
"uniprot_ac": "P32801",
"gene_name": "ELM1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32801"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P32801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32801"
}
]
}
]
},
{
"uniprot_ac": "P32944",
"gene_name": "SWE1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P32944",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32944"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P32944",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P32944"
}
]
}
]
},
{
"uniprot_ac": "P33076",
"gene_name": "CIITA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P33076",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33076"
}
]
},
{
"ec_number": "2.3.1.-",
"activity": "",
"evidence": [
{
"id": "P33076",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33076"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P33076",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33076"
}
]
}
]
},
{
"uniprot_ac": "P33981",
"gene_name": "TTK",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P33981",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33981"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P33981",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P33981"
}
]
}
]
},
{
"uniprot_ac": "P34099",
"gene_name": "pkaC",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34099"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P34099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34099"
}
]
}
]
},
{
"uniprot_ac": "P34100",
"gene_name": "pkaD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34100"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P34100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34100"
}
]
}
]
},
{
"uniprot_ac": "P34101",
"gene_name": "fhkC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34101",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34101"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P34101",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34101"
}
]
}
]
},
{
"uniprot_ac": "P34102",
"gene_name": "pkgC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34102",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34102"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P34102",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34102"
}
]
}
]
},
{
"uniprot_ac": "P34103",
"gene_name": "pkgD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34103",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34103"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P34103",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34103"
}
]
}
]
},
{
"uniprot_ac": "P34112",
"gene_name": "cdk1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34112"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P34112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34112"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P34112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34112"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P34112",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34112"
}
]
}
]
},
{
"uniprot_ac": "P34117",
"gene_name": "cdk5",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34117",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34117"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P34117",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34117"
}
]
}
]
},
{
"uniprot_ac": "P34244",
"gene_name": "HSL1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P34244",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34244"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P34244",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P34244"
}
]
}
]
},
{
"uniprot_ac": "P35169",
"gene_name": "TOR1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P35169",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35169"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P35169",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35169"
}
]
}
]
},
{
"uniprot_ac": "P35426",
"gene_name": "Cdk4",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P35426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35426"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P35426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35426"
}
]
}
]
},
{
"uniprot_ac": "P35465",
"gene_name": "Pak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P35465",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35465"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P35465",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35465"
}
]
}
]
},
{
"uniprot_ac": "P35761",
"gene_name": "Ttk",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P35761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35761"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P35761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P35761"
}
]
}
]
},
{
"uniprot_ac": "P36002",
"gene_name": "PTK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P36002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36002"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P36002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36002"
}
]
}
]
},
{
"uniprot_ac": "P36003",
"gene_name": "NNK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P36003",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36003"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P36003",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36003"
}
]
}
]
},
{
"uniprot_ac": "P36004",
"gene_name": "KKQ8",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P36004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36004"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P36004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36004"
}
]
}
]
},
{
"uniprot_ac": "P36005",
"gene_name": "KDX1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P36005",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36005"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P36005",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36005"
}
]
}
]
},
{
"uniprot_ac": "P36506",
"gene_name": "Map2k2",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P36506",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36506"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P36506",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36506"
}
]
}
]
},
{
"uniprot_ac": "P36507",
"gene_name": "MAP2K2",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P36507",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36507"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P36507",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36507"
}
]
}
]
},
{
"uniprot_ac": "P36873",
"gene_name": "PPP1CC",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P36873",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36873"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P36873",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P36873"
}
]
}
]
},
{
"uniprot_ac": "P38070",
"gene_name": "YPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38070"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38070"
}
]
}
]
},
{
"uniprot_ac": "P38080",
"gene_name": "AKL1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38080",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38080"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38080",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38080"
}
]
}
]
},
{
"uniprot_ac": "P38110",
"gene_name": "TEL1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38110"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38110",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38110"
}
]
}
]
},
{
"uniprot_ac": "P38111",
"gene_name": "MEC1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38111"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38111"
}
]
}
]
},
{
"uniprot_ac": "P38147",
"gene_name": "CHK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38147"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38147"
}
]
}
]
},
{
"uniprot_ac": "P38615",
"gene_name": "RIM11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38615",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38615"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38615",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38615"
}
]
}
]
},
{
"uniprot_ac": "P38622",
"gene_name": "RCK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38622",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38622"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38622",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38622"
}
]
}
]
},
{
"uniprot_ac": "P38623",
"gene_name": "RCK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38623",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38623"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38623",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38623"
}
]
}
]
},
{
"uniprot_ac": "P38691",
"gene_name": "KSP1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38691",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38691"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38691",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38691"
}
]
}
]
},
{
"uniprot_ac": "P38692",
"gene_name": "KIC1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38692",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38692"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38692",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38692"
}
]
}
]
},
{
"uniprot_ac": "P38970",
"gene_name": "HAL5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38970",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38970"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38970",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38970"
}
]
}
]
},
{
"uniprot_ac": "P38990",
"gene_name": "SAK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38990",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38990"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38990",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38990"
}
]
}
]
},
{
"uniprot_ac": "P38991",
"gene_name": "IPL1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P38991",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38991"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P38991",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38991"
}
]
}
]
},
{
"uniprot_ac": "P39009",
"gene_name": "DUN1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P39009",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39009"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P39009",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39009"
}
]
}
]
},
{
"uniprot_ac": "P39073",
"gene_name": "SSN3",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P39073",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39073"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P39073",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39073"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P39073",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39073"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P39073",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39073"
}
]
}
]
},
{
"uniprot_ac": "P39951",
"gene_name": "Cdk1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P39951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39951"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P39951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39951"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P39951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39951"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P39951",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39951"
}
]
}
]
},
{
"uniprot_ac": "P39962",
"gene_name": "YCK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P39962",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39962"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P39962",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P39962"
}
]
}
]
},
{
"uniprot_ac": "P40160",
"gene_name": "RIO2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P40160",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40160"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P40160",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40160"
}
]
}
]
},
{
"uniprot_ac": "P40417",
"gene_name": "rl",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P40417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40417"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P40417",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40417"
}
]
}
]
},
{
"uniprot_ac": "P40494",
"gene_name": "PRK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P40494",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40494"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P40494",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P40494"
}
]
}
]
},
{
"uniprot_ac": "P41240",
"gene_name": "CSK",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P41240",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41240"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P41240",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41240"
}
]
}
]
},
{
"uniprot_ac": "P41279",
"gene_name": "MAP3K8",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P41279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41279"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P41279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41279"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P41279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41279"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P41279",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41279"
}
]
}
]
},
{
"uniprot_ac": "P41695",
"gene_name": "BUB1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P41695",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41695"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P41695",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41695"
}
]
}
]
},
{
"uniprot_ac": "P41743",
"gene_name": "PRKCI",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P41743",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41743"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P41743",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41743"
}
]
}
]
},
{
"uniprot_ac": "P41808",
"gene_name": "SMK1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P41808",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41808"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P41808",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P41808"
}
]
}
]
},
{
"uniprot_ac": "P42336",
"gene_name": "PIK3CA",
"activity": [
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
}
]
},
{
"uniprot_ac": "P42337",
"gene_name": "Pik3ca",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42337"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42337"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42337"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P42337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42337"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P42337",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42337"
}
]
}
]
},
{
"uniprot_ac": "P42338",
"gene_name": "PIK3CB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
}
]
},
{
"uniprot_ac": "P42345",
"gene_name": "MTOR",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42345",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42345"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P42345",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42345"
}
]
}
]
},
{
"uniprot_ac": "P42346",
"gene_name": "Mtor",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42346",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42346"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P42346",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42346"
}
]
}
]
},
{
"uniprot_ac": "P42525",
"gene_name": "erkA",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42525"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P42525",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42525"
}
]
}
]
},
{
"uniprot_ac": "P43565",
"gene_name": "RIM15",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P43565",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43565"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P43565",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43565"
}
]
}
]
},
{
"uniprot_ac": "P43568",
"gene_name": "CAK1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P43568",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43568"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P43568",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43568"
}
]
}
]
},
{
"uniprot_ac": "P43633",
"gene_name": "ALK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P43633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43633"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P43633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43633"
}
]
}
]
},
{
"uniprot_ac": "P43637",
"gene_name": "TOS3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P43637",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43637"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P43637",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P43637"
}
]
}
]
},
{
"uniprot_ac": "P45983",
"gene_name": "MAPK8",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P45983",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45983"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P45983",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45983"
}
]
}
]
},
{
"uniprot_ac": "P45984",
"gene_name": "MAPK9",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P45984",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45984"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P45984",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45984"
}
]
}
]
},
{
"uniprot_ac": "P45985",
"gene_name": "MAP2K4",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P45985",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45985"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P45985",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P45985"
}
]
}
]
},
{
"uniprot_ac": "P46734",
"gene_name": "MAP2K3",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P46734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46734"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P46734",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46734"
}
]
}
]
},
{
"uniprot_ac": "P46892",
"gene_name": "Cdk11b",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P46892",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P46892"
}
]
}
]
},
{
"uniprot_ac": "P47042",
"gene_name": "IKS1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P47042",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47042"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P47042",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47042"
}
]
}
]
},
{
"uniprot_ac": "P47116",
"gene_name": "PTK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P47116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47116"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P47116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47116"
}
]
}
]
},
{
"uniprot_ac": "P47196",
"gene_name": "Akt1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P47196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47196"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P47196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47196"
}
]
}
]
},
{
"uniprot_ac": "P47197",
"gene_name": "Akt2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P47197",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47197"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P47197",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47197"
}
]
}
]
},
{
"uniprot_ac": "P47809",
"gene_name": "Map2k4",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P47809",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47809"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P47809",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47809"
}
]
}
]
},
{
"uniprot_ac": "P47811",
"gene_name": "Mapk14",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P47811",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47811"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P47811",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P47811"
}
]
}
]
},
{
"uniprot_ac": "P48562",
"gene_name": "CLA4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P48562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48562"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P48562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48562"
}
]
}
]
},
{
"uniprot_ac": "P48609",
"gene_name": "Cdk5",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P48609",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48609"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P48609",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48609"
}
]
}
]
},
{
"uniprot_ac": "P48729",
"gene_name": "CSNK1A1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P48729",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48729"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P48729",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48729"
}
]
}
]
},
{
"uniprot_ac": "P48730",
"gene_name": "CSNK1D",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P48730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48730"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P48730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48730"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "P48730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48730"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P48730",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48730"
}
]
}
]
},
{
"uniprot_ac": "P48736",
"gene_name": "PIK3CG",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
}
]
},
{
"uniprot_ac": "P49025",
"gene_name": "Cit",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49025",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49025"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P49025",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49025"
}
]
}
]
},
{
"uniprot_ac": "P49071",
"gene_name": "MAPk-Ak2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49071",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49071"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P49071",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49071"
}
]
}
]
},
{
"uniprot_ac": "P49137",
"gene_name": "MAPKAPK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49137"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P49137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49137"
}
]
}
]
},
{
"uniprot_ac": "P49138",
"gene_name": "Mapkapk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49138",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49138"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P49138",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49138"
}
]
}
]
},
{
"uniprot_ac": "P49185",
"gene_name": "Mapk8",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49185"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P49185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49185"
}
]
}
]
},
{
"uniprot_ac": "P49186",
"gene_name": "Mapk9",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49186"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P49186",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49186"
}
]
}
]
},
{
"uniprot_ac": "P49187",
"gene_name": "Mapk10",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49187"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P49187",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49187"
}
]
}
]
},
{
"uniprot_ac": "P49336",
"gene_name": "CDK8",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49336"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P49336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49336"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P49336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49336"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P49336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49336"
}
]
}
]
},
{
"uniprot_ac": "P49615",
"gene_name": "Cdk5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49615",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49615"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P49615",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49615"
}
]
}
]
},
{
"uniprot_ac": "P49657",
"gene_name": "mnb",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49657",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49657"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P49657",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49657"
}
]
}
]
},
{
"uniprot_ac": "P49674",
"gene_name": "CSNK1E",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49674",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49674"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P49674",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49674"
}
]
}
]
},
{
"uniprot_ac": "P49759",
"gene_name": "CLK1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49759"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P49759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49759"
}
]
}
]
},
{
"uniprot_ac": "P49760",
"gene_name": "CLK2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49760",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49760"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P49760",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49760"
}
]
}
]
},
{
"uniprot_ac": "P49761",
"gene_name": "CLK3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49761"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P49761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49761"
}
]
}
]
},
{
"uniprot_ac": "P49762",
"gene_name": "Doa",
"activity": [
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "P49762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49762"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49762"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P49762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49762"
}
]
}
]
},
{
"uniprot_ac": "P49840",
"gene_name": "GSK3A",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49840",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49840"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P49840",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49840"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "P49840",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49840"
}
]
}
]
},
{
"uniprot_ac": "P49841",
"gene_name": "GSK3B",
"activity": [
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P49841",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49841"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "P49841",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49841"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P49841",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P49841"
}
]
}
]
},
{
"uniprot_ac": "P50613",
"gene_name": "CDK7",
"activity": [
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P50613",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50613"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P50613",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50613"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P50613",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50613"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P50613",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50613"
}
]
}
]
},
{
"uniprot_ac": "P50750",
"gene_name": "CDK9",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P50750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50750"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P50750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50750"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P50750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50750"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P50750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50750"
}
]
}
]
},
{
"uniprot_ac": "P50873",
"gene_name": "MRK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P50873",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50873"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P50873",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50873"
}
]
}
]
},
{
"uniprot_ac": "P51123",
"gene_name": "Taf1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51123",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51123"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51123",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51123"
}
]
}
]
},
{
"uniprot_ac": "P51617",
"gene_name": "IRAK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51617",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51617"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51617",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51617"
}
]
}
]
},
{
"uniprot_ac": "P51812",
"gene_name": "RPS6KA3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51812",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51812"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51812",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51812"
}
]
}
]
},
{
"uniprot_ac": "P51817",
"gene_name": "PRKX",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51817",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51817"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51817",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51817"
}
]
}
]
},
{
"uniprot_ac": "P51952",
"gene_name": "Cdk7",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51952",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51952"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P51952",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51952"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P51952",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51952"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P51952",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51952"
}
]
}
]
},
{
"uniprot_ac": "P51954",
"gene_name": "Nek1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51954",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51954"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51954",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51954"
}
]
}
]
},
{
"uniprot_ac": "P51955",
"gene_name": "NEK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51955",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51955"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51955",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51955"
}
]
}
]
},
{
"uniprot_ac": "P51956",
"gene_name": "NEK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51956",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51956"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51956",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51956"
}
]
}
]
},
{
"uniprot_ac": "P51957",
"gene_name": "NEK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P51957",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51957"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P51957",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51957"
}
]
}
]
},
{
"uniprot_ac": "P52304",
"gene_name": "polo",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P52304",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52304"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "P52304",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52304"
}
]
}
]
},
{
"uniprot_ac": "P52480",
"gene_name": "Pkm",
"activity": [
{
"ec_number": "2.7.1.40",
"activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.",
"evidence": [
{
"id": "P52480",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52480"
}
]
},
{
"ec_number": "2.7.1.40",
"activity": "",
"evidence": [
{
"id": "P52480",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52480"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P52480",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52480"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P52480",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52480"
}
]
}
]
},
{
"uniprot_ac": "P52564",
"gene_name": "MAP2K6",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P52564",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52564"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P52564",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52564"
}
]
}
]
},
{
"uniprot_ac": "P53041",
"gene_name": "PPP5C",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P53041",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53041"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P53041",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53041"
}
]
}
]
},
{
"uniprot_ac": "P53104",
"gene_name": "ATG1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53104",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53104"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53104",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53104"
}
]
}
]
},
{
"uniprot_ac": "P53233",
"gene_name": "FMP48",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53233",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53233"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53233",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53233"
}
]
}
]
},
{
"uniprot_ac": "P53323",
"gene_name": "BUD32",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53323",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53323"
}
]
},
{
"ec_number": "3.6.-.-",
"activity": "",
"evidence": [
{
"id": "P53323",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53323"
}
]
}
]
},
{
"uniprot_ac": "P53349",
"gene_name": "Map3k1",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53349",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53349"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P53349",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53349"
}
]
}
]
},
{
"uniprot_ac": "P53350",
"gene_name": "PLK1",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53350"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "P53350",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53350"
}
]
}
]
},
{
"uniprot_ac": "P53351",
"gene_name": "Plk2",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53351"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "P53351",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53351"
}
]
}
]
},
{
"uniprot_ac": "P53355",
"gene_name": "DAPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53355",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53355"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53355",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53355"
}
]
}
]
},
{
"uniprot_ac": "P53599",
"gene_name": "SSK2",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53599",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53599"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P53599",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53599"
}
]
}
]
},
{
"uniprot_ac": "P53667",
"gene_name": "LIMK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53667",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53667"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53667",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53667"
}
]
}
]
},
{
"uniprot_ac": "P53668",
"gene_name": "Limk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53668"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53668",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53668"
}
]
}
]
},
{
"uniprot_ac": "P53669",
"gene_name": "Limk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53669"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53669",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53669"
}
]
}
]
},
{
"uniprot_ac": "P53670",
"gene_name": "Limk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53670"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53670"
}
]
}
]
},
{
"uniprot_ac": "P53671",
"gene_name": "LIMK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53671",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53671"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53671",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53671"
}
]
}
]
},
{
"uniprot_ac": "P53739",
"gene_name": "FPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53739",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53739"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53739",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53739"
}
]
}
]
},
{
"uniprot_ac": "P53778",
"gene_name": "MAPK12",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53778",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53778"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P53778",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53778"
}
]
}
]
},
{
"uniprot_ac": "P53779",
"gene_name": "MAPK10",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53779",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53779"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P53779",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53779"
}
]
}
]
},
{
"uniprot_ac": "P53894",
"gene_name": "CBK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53894",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53894"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53894",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53894"
}
]
}
]
},
{
"uniprot_ac": "P53974",
"gene_name": "ARK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P53974",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53974"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P53974",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P53974"
}
]
}
]
},
{
"uniprot_ac": "P54199",
"gene_name": "MPS1",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54199",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54199"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P54199",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54199"
}
]
}
]
},
{
"uniprot_ac": "P54265",
"gene_name": "Dmpk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54265"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54265"
}
]
}
]
},
{
"uniprot_ac": "P54360",
"gene_name": "fj",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54360",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54360"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54360",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54360"
}
]
}
]
},
{
"uniprot_ac": "P54367",
"gene_name": "CkIalpha",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54367",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54367"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54367",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54367"
}
]
}
]
},
{
"uniprot_ac": "P54644",
"gene_name": "pkbA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54644"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54644"
}
]
}
]
},
{
"uniprot_ac": "P54645",
"gene_name": "Prkaa1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54645",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54645"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "P54645",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54645"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54645",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54645"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "",
"evidence": [
{
"id": "P54645",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54645"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "P54645",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54645"
}
]
}
]
},
{
"uniprot_ac": "P54646",
"gene_name": "PRKAA2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54646"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "P54646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54646"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P54646",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54646"
}
]
}
]
},
{
"uniprot_ac": "P54685",
"gene_name": "cdk7",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P54685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54685"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "P54685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54685"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "P54685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54685"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P54685",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P54685"
}
]
}
]
},
{
"uniprot_ac": "P57058",
"gene_name": "HUNK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P57058",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57058"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P57058",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57058"
}
]
}
]
},
{
"uniprot_ac": "P57059",
"gene_name": "SIK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P57059",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57059"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P57059",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57059"
}
]
}
]
},
{
"uniprot_ac": "P57078",
"gene_name": "RIPK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P57078",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57078"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P57078",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57078"
}
]
}
]
},
{
"uniprot_ac": "P57760",
"gene_name": "Stk16",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P57760",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57760"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P57760",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57760"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P57760",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P57760"
}
]
}
]
},
{
"uniprot_ac": "P58750",
"gene_name": "Pim3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P58750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58750"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P58750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58750"
}
]
}
]
},
{
"uniprot_ac": "P58801",
"gene_name": "Ripk2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P58801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58801"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P58801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58801"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P58801",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P58801"
}
]
}
]
},
{
"uniprot_ac": "P59241",
"gene_name": "Aurka",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P59241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P59241"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P59241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P59241"
}
]
}
]
},
{
"uniprot_ac": "P59895",
"gene_name": "Nek6",
"activity": [
{
"ec_number": "2.7.11.34",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P59895",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P59895"
}
]
},
{
"ec_number": "2.7.11.34",
"activity": "",
"evidence": [
{
"id": "P59895",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P59895"
}
]
}
]
},
{
"uniprot_ac": "P60709",
"gene_name": "ACTB",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P60709",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P60709"
}
]
}
]
},
{
"uniprot_ac": "P61224",
"gene_name": "RAP1B",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P61224",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61224"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P61224",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P61224"
}
]
}
]
},
{
"uniprot_ac": "P62140",
"gene_name": "PPP1CB",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P62140",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62140"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P62140",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62140"
}
]
},
{
"ec_number": "3.1.3.53",
"activity": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate.",
"evidence": [
{
"id": "P62140",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62140"
}
]
},
{
"ec_number": "3.1.3.53",
"activity": "",
"evidence": [
{
"id": "P62140",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62140"
}
]
}
]
},
{
"uniprot_ac": "P62714",
"gene_name": "PPP2CB",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P62714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62714"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P62714",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62714"
}
]
}
]
},
{
"uniprot_ac": "P62834",
"gene_name": "RAP1A",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P62834",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62834"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P62834",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62834"
}
]
}
]
},
{
"uniprot_ac": "P63085",
"gene_name": "Mapk1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P63085",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63085"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P63085",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63085"
}
]
}
]
},
{
"uniprot_ac": "P63086",
"gene_name": "Mapk1",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P63086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63086"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P63086",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63086"
}
]
}
]
},
{
"uniprot_ac": "P63261",
"gene_name": "ACTG1",
"activity": [
{
"ec_number": "3.6.4.-",
"activity": "",
"evidence": [
{
"id": "P63261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63261"
}
]
}
]
},
{
"uniprot_ac": "P63318",
"gene_name": "Prkcg",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P63318",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63318"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P63318",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63318"
}
]
}
]
},
{
"uniprot_ac": "P63319",
"gene_name": "Prkcg",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P63319",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63319"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P63319",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P63319"
}
]
}
]
},
{
"uniprot_ac": "P67775",
"gene_name": "PPP2CA",
"activity": [
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "P67775",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P67775"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "",
"evidence": [
{
"id": "P67775",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P67775"
}
]
}
]
},
{
"uniprot_ac": "P67999",
"gene_name": "Rps6kb1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P67999",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P67999"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P67999",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P67999"
}
]
}
]
},
{
"uniprot_ac": "P68181",
"gene_name": "Prkacb",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P68181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68181"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P68181",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68181"
}
]
}
]
},
{
"uniprot_ac": "P68182",
"gene_name": "Prkacb",
"activity": [
{
"ec_number": "2.7.11.11",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P68182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68182"
}
]
},
{
"ec_number": "2.7.11.11",
"activity": "",
"evidence": [
{
"id": "P68182",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68182"
}
]
}
]
},
{
"uniprot_ac": "P68400",
"gene_name": "CSNK2A1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P68400",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68400"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P68400",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68400"
}
]
}
]
},
{
"uniprot_ac": "P68403",
"gene_name": "Prkcb",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P68403",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68403"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P68403",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68403"
}
]
}
]
},
{
"uniprot_ac": "P68404",
"gene_name": "Prkcb",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P68404",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68404"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P68404",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P68404"
}
]
}
]
},
{
"uniprot_ac": "P70218",
"gene_name": "Map4k1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P70218",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70218"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P70218",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70218"
}
]
}
]
},
{
"uniprot_ac": "P70236",
"gene_name": "Map2k6",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P70236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70236"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "P70236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70236"
}
]
}
]
},
{
"uniprot_ac": "P70268",
"gene_name": "Pkn1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P70268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70268"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P70268",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70268"
}
]
}
]
},
{
"uniprot_ac": "P70335",
"gene_name": "Rock1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P70335",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70335"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P70335",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70335"
}
]
}
]
},
{
"uniprot_ac": "P70336",
"gene_name": "Rock2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P70336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70336"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P70336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70336"
}
]
}
]
},
{
"uniprot_ac": "P70618",
"gene_name": "Mapk14",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P70618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70618"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P70618",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P70618"
}
]
}
]
},
{
"uniprot_ac": "P78362",
"gene_name": "SRPK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P78362",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78362"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P78362",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78362"
}
]
}
]
},
{
"uniprot_ac": "P78368",
"gene_name": "CSNK1G2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P78368",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78368"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P78368",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78368"
}
]
}
]
},
{
"uniprot_ac": "P78527",
"gene_name": "PRKDC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P78527",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78527"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P78527",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P78527"
}
]
}
]
},
{
"uniprot_ac": "P79621",
"gene_name": "Ciita",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P79621",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P79621"
}
]
},
{
"ec_number": "2.3.1.-",
"activity": "",
"evidence": [
{
"id": "P79621",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P79621"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P79621",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P79621"
}
]
}
]
},
{
"uniprot_ac": "P80192",
"gene_name": "MAP3K9",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P80192",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P80192"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P80192",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P80192"
}
]
}
]
},
{
"uniprot_ac": "P83098",
"gene_name": "Stlk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83098"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P83098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83098"
}
]
}
]
},
{
"uniprot_ac": "P83099",
"gene_name": "Pkcdelta",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83099"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "P83099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83099"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "P83099",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83099"
}
]
}
]
},
{
"uniprot_ac": "P83100",
"gene_name": "p38c",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83100"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P83100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83100"
}
]
}
]
},
{
"uniprot_ac": "P83102",
"gene_name": "Dyrk3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83102",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83102"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "P83102",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83102"
}
]
}
]
},
{
"uniprot_ac": "P83103",
"gene_name": "Haspin",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83103",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83103"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P83103",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83103"
}
]
}
]
},
{
"uniprot_ac": "P83104",
"gene_name": "Takl1",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83104",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83104"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "P83104",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83104"
}
]
}
]
},
{
"uniprot_ac": "P83510",
"gene_name": "Tnik",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83510"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P83510",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83510"
}
]
}
]
},
{
"uniprot_ac": "P83741",
"gene_name": "Wnk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P83741",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83741"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P83741",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P83741"
}
]
}
]
},
{
"uniprot_ac": "P92208",
"gene_name": "bsk",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P92208",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P92208"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "P92208",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P92208"
}
]
}
]
},
{
"uniprot_ac": "P97313",
"gene_name": "Prkdc",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97313",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97313"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97313",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97313"
}
]
}
]
},
{
"uniprot_ac": "P97343",
"gene_name": "Uhmk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97343",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97343"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97343",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97343"
}
]
}
]
},
{
"uniprot_ac": "P97377",
"gene_name": "Cdk2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97377",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97377"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "P97377",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97377"
}
]
}
]
},
{
"uniprot_ac": "P97477",
"gene_name": "Aurka",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97477"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97477",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97477"
}
]
}
]
},
{
"uniprot_ac": "P97633",
"gene_name": "Csnk1a1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97633"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97633",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97633"
}
]
}
]
},
{
"uniprot_ac": "P97756",
"gene_name": "Camkk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97756",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97756"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97756",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97756"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97756",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97756"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "P97756",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97756"
}
]
}
]
},
{
"uniprot_ac": "P97820",
"gene_name": "Map4k4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97820",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97820"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97820",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97820"
}
]
}
]
},
{
"uniprot_ac": "P97874",
"gene_name": "Gak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97874"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97874",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97874"
}
]
}
]
},
{
"uniprot_ac": "P97924",
"gene_name": "Kalrn",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P97924",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97924"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "P97924",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97924"
}
]
}
]
},
{
"uniprot_ac": "Q00168",
"gene_name": "CaMKII",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00168",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00168"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q00168",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00168"
}
]
}
]
},
{
"uniprot_ac": "Q00526",
"gene_name": "CDK3",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00526",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00526"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q00526",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00526"
}
]
}
]
},
{
"uniprot_ac": "Q00532",
"gene_name": "CDKL1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00532"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q00532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00532"
}
]
}
]
},
{
"uniprot_ac": "Q00534",
"gene_name": "CDK6",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00534",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00534"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q00534",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00534"
}
]
}
]
},
{
"uniprot_ac": "Q00535",
"gene_name": "CDK5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00535"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q00535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00535"
}
]
}
]
},
{
"uniprot_ac": "Q00536",
"gene_name": "CDK16",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00536",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00536"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q00536",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00536"
}
]
}
]
},
{
"uniprot_ac": "Q00537",
"gene_name": "CDK17",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00537",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00537"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q00537",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00537"
}
]
}
]
},
{
"uniprot_ac": "Q00772",
"gene_name": "SLT2",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00772"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q00772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00772"
}
]
}
]
},
{
"uniprot_ac": "Q00972",
"gene_name": "Bckdk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q00972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00972"
}
]
},
{
"ec_number": "2.7.11.4",
"activity": "ATP + L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = ADP + H(+) + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase].",
"evidence": [
{
"id": "Q00972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00972"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q00972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00972"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].",
"evidence": [
{
"id": "Q00972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00972"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "",
"evidence": [
{
"id": "Q00972",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q00972"
}
]
}
]
},
{
"uniprot_ac": "Q01389",
"gene_name": "BCK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q01389",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01389"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q01389",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01389"
}
]
}
]
},
{
"uniprot_ac": "Q01919",
"gene_name": "KIN4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q01919",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01919"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q01919",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01919"
}
]
}
]
},
{
"uniprot_ac": "Q01986",
"gene_name": "Map2k1",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q01986",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01986"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q01986",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01986"
}
]
}
]
},
{
"uniprot_ac": "Q02111",
"gene_name": "Prkcq",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q02111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02111"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q02111",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02111"
}
]
}
]
},
{
"uniprot_ac": "Q02156",
"gene_name": "PRKCE",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q02156",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02156"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q02156",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02156"
}
]
}
]
},
{
"uniprot_ac": "Q02720",
"gene_name": "casK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q02720",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02720"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q02720",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02720"
}
]
}
]
},
{
"uniprot_ac": "Q02750",
"gene_name": "MAP2K1",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q02750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02750"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q02750",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02750"
}
]
}
]
},
{
"uniprot_ac": "Q02779",
"gene_name": "MAP3K10",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q02779",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02779"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q02779",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02779"
}
]
}
]
},
{
"uniprot_ac": "Q02956",
"gene_name": "Prkcz",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q02956",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02956"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q02956",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q02956"
}
]
}
]
},
{
"uniprot_ac": "Q03002",
"gene_name": "FRK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03002"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03002"
}
]
}
]
},
{
"uniprot_ac": "Q03042",
"gene_name": "Pkg21D",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03042",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03042"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q03042",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03042"
}
]
}
]
},
{
"uniprot_ac": "Q03043",
"gene_name": "for",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03043",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03043"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q03043",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03043"
}
]
}
]
},
{
"uniprot_ac": "Q03114",
"gene_name": "Cdk5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03114",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03114"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03114",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03114"
}
]
}
]
},
{
"uniprot_ac": "Q03141",
"gene_name": "Mark3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03141"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03141",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03141"
}
]
}
]
},
{
"uniprot_ac": "Q03147",
"gene_name": "Cdk7",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03147"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q03147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03147"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q03147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03147"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q03147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03147"
}
]
}
]
},
{
"uniprot_ac": "Q03306",
"gene_name": "PKH3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03306",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03306"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03306",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03306"
}
]
}
]
},
{
"uniprot_ac": "Q03407",
"gene_name": "PKH1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03407",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03407"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03407",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03407"
}
]
}
]
},
{
"uniprot_ac": "Q03497",
"gene_name": "STE20",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03497",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03497"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03497",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03497"
}
]
}
]
},
{
"uniprot_ac": "Q03533",
"gene_name": "TDA1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03533",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03533"
}
]
}
]
},
{
"uniprot_ac": "Q03656",
"gene_name": "SKY1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03656"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03656",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03656"
}
]
}
]
},
{
"uniprot_ac": "Q03785",
"gene_name": "VHS1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03785",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03785"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03785",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03785"
}
]
}
]
},
{
"uniprot_ac": "Q03963",
"gene_name": "Eif2ak2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q03963",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03963"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q03963",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03963"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q03963",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q03963"
}
]
}
]
},
{
"uniprot_ac": "Q04735",
"gene_name": "Cdk16",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q04735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04735"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q04735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04735"
}
]
}
]
},
{
"uniprot_ac": "Q04759",
"gene_name": "PRKCQ",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q04759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04759"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q04759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04759"
}
]
}
]
},
{
"uniprot_ac": "Q04859",
"gene_name": "Mak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q04859",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04859"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q04859",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04859"
}
]
}
]
},
{
"uniprot_ac": "Q04899",
"gene_name": "Cdk18",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q04899",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04899"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q04899",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q04899"
}
]
}
]
},
{
"uniprot_ac": "Q05512",
"gene_name": "Mark2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q05512",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05512"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q05512",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05512"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q05512",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05512"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q05512",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05512"
}
]
}
]
},
{
"uniprot_ac": "Q05513",
"gene_name": "PRKCZ",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q05513",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05513"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q05513",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05513"
}
]
}
]
},
{
"uniprot_ac": "Q05652",
"gene_name": "pll",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q05652",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05652"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q05652",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05652"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "Q05652",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05652"
}
]
}
]
},
{
"uniprot_ac": "Q05655",
"gene_name": "PRKCD",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q05655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05655"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q05655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05655"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q05655",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q05655"
}
]
}
]
},
{
"uniprot_ac": "Q06098",
"gene_name": "ISR1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q06098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06098"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q06098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06098"
}
]
}
]
},
{
"uniprot_ac": "Q06226",
"gene_name": "Sgk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q06226",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06226"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q06226",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06226"
}
]
}
]
},
{
"uniprot_ac": "Q06486",
"gene_name": "Csnk1d",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q06486",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06486"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q06486",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06486"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q06486",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06486"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q06486",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06486"
}
]
}
]
},
{
"uniprot_ac": "Q07002",
"gene_name": "CDK18",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q07002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07002"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q07002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07002"
}
]
}
]
},
{
"uniprot_ac": "Q07174",
"gene_name": "Map3k8",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q07174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07174"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q07174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07174"
}
]
}
]
},
{
"uniprot_ac": "Q07832",
"gene_name": "Plk1",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q07832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07832"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q07832",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07832"
}
]
}
]
},
{
"uniprot_ac": "Q07912",
"gene_name": "TNK2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q07912",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07912"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "Q07912",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07912"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q07912",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07912"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q07912",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07912"
}
]
}
]
},
{
"uniprot_ac": "Q08217",
"gene_name": "PSK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q08217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08217"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q08217",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08217"
}
]
}
]
},
{
"uniprot_ac": "Q08732",
"gene_name": "HRK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q08732",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08732"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q08732",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q08732"
}
]
}
]
},
{
"uniprot_ac": "Q09013",
"gene_name": "DMPK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q09013",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09013"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q09013",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09013"
}
]
}
]
},
{
"uniprot_ac": "Q09137",
"gene_name": "Prkaa2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q09137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09137"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "Q09137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09137"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q09137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09137"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "",
"evidence": [
{
"id": "Q09137",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q09137"
}
]
}
]
},
{
"uniprot_ac": "Q0KHQ5",
"gene_name": "Tao",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q0KHQ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KHQ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q0KHQ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KHQ5"
}
]
}
]
},
{
"uniprot_ac": "Q0KHT7",
"gene_name": "Drak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q0KHT7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KHT7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q0KHT7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KHT7"
}
]
}
]
},
{
"uniprot_ac": "Q0KHV6",
"gene_name": "Pink1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q0KHV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KHV6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q0KHV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KHV6"
}
]
}
]
},
{
"uniprot_ac": "Q0KL02",
"gene_name": "Trio",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q0KL02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KL02"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q0KL02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q0KL02"
}
]
}
]
},
{
"uniprot_ac": "Q12003",
"gene_name": "ENV7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12003",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12003"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12003",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12003"
}
]
}
]
},
{
"uniprot_ac": "Q12100",
"gene_name": "RTK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12100"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12100",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12100"
}
]
}
]
},
{
"uniprot_ac": "Q12152",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12152",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12152"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12152",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12152"
}
]
}
]
},
{
"uniprot_ac": "Q12196",
"gene_name": "RIO1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12196"
}
]
},
{
"ec_number": "3.6.3.-",
"activity": "",
"evidence": [
{
"id": "Q12196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12196"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12196",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12196"
}
]
}
]
},
{
"uniprot_ac": "Q12222",
"gene_name": "YGK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12222",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12222"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12222",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12222"
}
]
}
]
},
{
"uniprot_ac": "Q12236",
"gene_name": "PKH2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12236"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12236",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12236"
}
]
}
]
},
{
"uniprot_ac": "Q12263",
"gene_name": "GIN4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12263",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12263"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12263",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12263"
}
]
}
]
},
{
"uniprot_ac": "Q12310",
"gene_name": "PRR2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12310",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12310"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12310",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12310"
}
]
}
]
},
{
"uniprot_ac": "Q12469",
"gene_name": "SKM1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12469",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12469"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12469",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12469"
}
]
}
]
},
{
"uniprot_ac": "Q12505",
"gene_name": "SKS1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12505",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12505"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12505",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12505"
}
]
}
]
},
{
"uniprot_ac": "Q12851",
"gene_name": "MAP4K2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12851",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12851"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q12851",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12851"
}
]
}
]
},
{
"uniprot_ac": "Q12852",
"gene_name": "MAP3K12",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q12852",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12852"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q12852",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q12852"
}
]
}
]
},
{
"uniprot_ac": "Q13043",
"gene_name": "STK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13043",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13043"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13043",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13043"
}
]
}
]
},
{
"uniprot_ac": "Q13131",
"gene_name": "PRKAA1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13131"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "Q13131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13131"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "",
"evidence": [
{
"id": "Q13131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13131"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13131"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q13131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13131"
}
]
}
]
},
{
"uniprot_ac": "Q13153",
"gene_name": "PAK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13153",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13153"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13153",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13153"
}
]
}
]
},
{
"uniprot_ac": "Q13163",
"gene_name": "MAP2K5",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13163",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13163"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q13163",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13163"
}
]
}
]
},
{
"uniprot_ac": "Q13164",
"gene_name": "MAPK7",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13164"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q13164",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13164"
}
]
}
]
},
{
"uniprot_ac": "Q13177",
"gene_name": "PAK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13177"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13177",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13177"
}
]
}
]
},
{
"uniprot_ac": "Q13188",
"gene_name": "STK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13188",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13188"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13188",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13188"
}
]
}
]
},
{
"uniprot_ac": "Q13233",
"gene_name": "MAP3K1",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q13233",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13233"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13233",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13233"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q13233",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13233"
}
]
}
]
},
{
"uniprot_ac": "Q13237",
"gene_name": "PRKG2",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13237",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13237"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q13237",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13237"
}
]
}
]
},
{
"uniprot_ac": "Q13315",
"gene_name": "ATM",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13315"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13315",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13315"
}
]
}
]
},
{
"uniprot_ac": "Q13418",
"gene_name": "ILK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13418",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13418"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13418",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13418"
}
]
}
]
},
{
"uniprot_ac": "Q13464",
"gene_name": "ROCK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13464"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13464",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13464"
}
]
}
]
},
{
"uniprot_ac": "Q13523",
"gene_name": "PRPF4B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13523",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13523"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13523",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13523"
}
]
}
]
},
{
"uniprot_ac": "Q13535",
"gene_name": "ATR",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13535"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13535",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13535"
}
]
}
]
},
{
"uniprot_ac": "Q13546",
"gene_name": "RIPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13546",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13546"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q13546",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13546"
}
]
}
]
},
{
"uniprot_ac": "Q13554",
"gene_name": "CAMK2B",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13554",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13554"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q13554",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13554"
}
]
}
]
},
{
"uniprot_ac": "Q13555",
"gene_name": "CAMK2G",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13555",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13555"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q13555",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13555"
}
]
}
]
},
{
"uniprot_ac": "Q13557",
"gene_name": "CAMK2D",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13557",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13557"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q13557",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13557"
}
]
}
]
},
{
"uniprot_ac": "Q13627",
"gene_name": "DYRK1A",
"activity": [
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q13627",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13627"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13627",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13627"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q13627",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13627"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q13627",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13627"
}
]
}
]
},
{
"uniprot_ac": "Q13976",
"gene_name": "PRKG1",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q13976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13976"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q13976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13976"
}
]
}
]
},
{
"uniprot_ac": "Q14004",
"gene_name": "CDK13",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q14004",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14004"
}
]
}
]
},
{
"uniprot_ac": "Q14012",
"gene_name": "CAMK1",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q14012",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14012"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q14012",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14012"
}
]
}
]
},
{
"uniprot_ac": "Q14296",
"gene_name": "FASTK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q14296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14296"
}
]
},
{
"ec_number": "2.7.11.8",
"activity": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein].",
"evidence": [
{
"id": "Q14296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14296"
}
]
},
{
"ec_number": "2.7.11.8",
"activity": "",
"evidence": [
{
"id": "Q14296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14296"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q14296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14296"
}
]
}
]
},
{
"uniprot_ac": "Q14680",
"gene_name": "MELK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q14680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14680"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q14680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14680"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q14680",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14680"
}
]
}
]
},
{
"uniprot_ac": "Q14AX6",
"gene_name": "Cdk12",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q14AX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14AX6"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q14AX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14AX6"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q14AX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14AX6"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q14AX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14AX6"
}
]
}
]
},
{
"uniprot_ac": "Q15131",
"gene_name": "CDK10",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15131"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q15131",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15131"
}
]
}
]
},
{
"uniprot_ac": "Q15139",
"gene_name": "PRKD1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15139"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q15139",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15139"
}
]
}
]
},
{
"uniprot_ac": "Q15208",
"gene_name": "STK38",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15208",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15208"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q15208",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15208"
}
]
}
]
},
{
"uniprot_ac": "Q15349",
"gene_name": "RPS6KA2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15349",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15349"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q15349",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15349"
}
]
}
]
},
{
"uniprot_ac": "Q15418",
"gene_name": "RPS6KA1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15418",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15418"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q15418",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15418"
}
]
}
]
},
{
"uniprot_ac": "Q15569",
"gene_name": "TESK1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15569",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15569"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q15569",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15569"
}
]
}
]
},
{
"uniprot_ac": "Q15759",
"gene_name": "MAPK11",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15759"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q15759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15759"
}
]
}
]
},
{
"uniprot_ac": "Q15772",
"gene_name": "SPEG",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15772"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q15772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15772"
}
]
}
]
},
{
"uniprot_ac": "Q15831",
"gene_name": "STK11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q15831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15831"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q15831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15831"
}
]
}
]
},
{
"uniprot_ac": "Q16512",
"gene_name": "PKN1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16512",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16512"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q16512",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16512"
}
]
}
]
},
{
"uniprot_ac": "Q16513",
"gene_name": "PKN2",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16513",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16513"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q16513",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16513"
}
]
}
]
},
{
"uniprot_ac": "Q16539",
"gene_name": "MAPK14",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16539",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16539"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q16539",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16539"
}
]
}
]
},
{
"uniprot_ac": "Q16566",
"gene_name": "CAMK4",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16566"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q16566",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16566"
}
]
}
]
},
{
"uniprot_ac": "Q16584",
"gene_name": "MAP3K11",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16584"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q16584",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16584"
}
]
}
]
},
{
"uniprot_ac": "Q16644",
"gene_name": "MAPKAPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16644"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q16644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16644"
}
]
}
]
},
{
"uniprot_ac": "Q16659",
"gene_name": "MAPK6",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16659",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16659"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q16659",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16659"
}
]
}
]
},
{
"uniprot_ac": "Q16816",
"gene_name": "PHKG1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q16816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16816"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q16816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16816"
}
]
},
{
"ec_number": "2.7.11.19",
"activity": "2 ATP + phosphorylase b = 2 ADP + phosphorylase a.",
"evidence": [
{
"id": "Q16816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16816"
}
]
},
{
"ec_number": "2.7.11.19",
"activity": "",
"evidence": [
{
"id": "Q16816",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16816"
}
]
}
]
},
{
"uniprot_ac": "Q1EG27",
"gene_name": "Myo3b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1EG27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1EG27"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q1EG27",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1EG27"
}
]
}
]
},
{
"uniprot_ac": "Q1HKZ5",
"gene_name": "Map3k13",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1HKZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1HKZ5"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q1HKZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1HKZ5"
}
]
}
]
},
{
"uniprot_ac": "Q1ZXC8",
"gene_name": "pXi",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1ZXC8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXC8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q1ZXC8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXC8"
}
]
}
]
},
{
"uniprot_ac": "Q1ZXD6",
"gene_name": "roco5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1ZXD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXD6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q1ZXD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXD6"
}
]
}
]
},
{
"uniprot_ac": "Q1ZXH2",
"gene_name": "fhkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1ZXH2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXH2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q1ZXH2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXH2"
}
]
}
]
},
{
"uniprot_ac": "Q1ZXI5",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1ZXI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXI5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q1ZXI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXI5"
}
]
}
]
},
{
"uniprot_ac": "Q1ZXR2",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q1ZXR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXR2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q1ZXR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q1ZXR2"
}
]
}
]
},
{
"uniprot_ac": "Q23915",
"gene_name": "kinX",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q23915",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q23915"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q23915",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q23915"
}
]
}
]
},
{
"uniprot_ac": "Q23977",
"gene_name": "hep",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q23977",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q23977"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q23977",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q23977"
}
]
}
]
},
{
"uniprot_ac": "Q24210",
"gene_name": "CASK",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q24210",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q24210"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q24210",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q24210"
}
]
}
]
},
{
"uniprot_ac": "Q24324",
"gene_name": "Dsor1",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q24324",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q24324"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q24324",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q24324"
}
]
}
]
},
{
"uniprot_ac": "Q2M2I8",
"gene_name": "AAK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q2M2I8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2M2I8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q2M2I8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2M2I8"
}
]
}
]
},
{
"uniprot_ac": "Q2NL51",
"gene_name": "Gsk3a",
"activity": [
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q2NL51",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2NL51"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q2NL51",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2NL51"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q2NL51",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q2NL51"
}
]
}
]
},
{
"uniprot_ac": "Q38SD2",
"gene_name": "LRRK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q38SD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q38SD2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q38SD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q38SD2"
}
]
}
]
},
{
"uniprot_ac": "Q3MJK5",
"gene_name": "Cdk12",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3MJK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3MJK5"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q3MJK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3MJK5"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q3MJK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3MJK5"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q3MJK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3MJK5"
}
]
}
]
},
{
"uniprot_ac": "Q3TYD6",
"gene_name": "Lmtk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3TYD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TYD6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3TYD6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TYD6"
}
]
}
]
},
{
"uniprot_ac": "Q3TZA2",
"gene_name": "Cdkl4",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3TZA2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TZA2"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q3TZA2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3TZA2"
}
]
}
]
},
{
"uniprot_ac": "Q3U1V8",
"gene_name": "Map3k9",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3U1V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U1V8"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q3U1V8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U1V8"
}
]
}
]
},
{
"uniprot_ac": "Q3U214",
"gene_name": "Mast3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3U214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U214"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3U214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U214"
}
]
}
]
},
{
"uniprot_ac": "Q3U3Q1",
"gene_name": "Ulk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3U3Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U3Q1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3U3Q1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3U3Q1"
}
]
}
]
},
{
"uniprot_ac": "Q3UGM2",
"gene_name": "Nek10",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UGM2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UGM2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UGM2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UGM2"
}
]
}
]
},
{
"uniprot_ac": "Q3UH66",
"gene_name": "Wnk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UH66",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UH66"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UH66",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UH66"
}
]
}
]
},
{
"uniprot_ac": "Q3UHC2",
"gene_name": "Lrrk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UHC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UHC2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UHC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UHC2"
}
]
}
]
},
{
"uniprot_ac": "Q3UHJ0",
"gene_name": "Aak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UHJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UHJ0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UHJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UHJ0"
}
]
}
]
},
{
"uniprot_ac": "Q3ULB5",
"gene_name": "Pak6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3ULB5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3ULB5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3ULB5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3ULB5"
}
]
}
]
},
{
"uniprot_ac": "Q3UMM4",
"gene_name": "Cdk10",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UMM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMM4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q3UMM4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMM4"
}
]
}
]
},
{
"uniprot_ac": "Q3UMW7",
"gene_name": "Mapkapk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UMW7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMW7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UMW7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UMW7"
}
]
}
]
},
{
"uniprot_ac": "Q3UT86",
"gene_name": "Gm5891",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UT86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UT86"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UT86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UT86"
}
]
}
]
},
{
"uniprot_ac": "Q3UTA8",
"gene_name": "Gm4567",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UTA8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UTA8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UTA8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UTA8"
}
]
}
]
},
{
"uniprot_ac": "Q3UTQ8",
"gene_name": "Cdkl5",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UTQ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UTQ8"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q3UTQ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UTQ8"
}
]
}
]
},
{
"uniprot_ac": "Q3UU96",
"gene_name": "Cdc42bpa",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UU96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UU96"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UU96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UU96"
}
]
}
]
},
{
"uniprot_ac": "Q3UVC0",
"gene_name": "Ksr2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UVC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UVC0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UVC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UVC0"
}
]
}
]
},
{
"uniprot_ac": "Q3UVR3",
"gene_name": "Ttbk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3UVR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UVR3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3UVR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3UVR3"
}
]
}
]
},
{
"uniprot_ac": "Q3V016",
"gene_name": "Hipk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3V016",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V016"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3V016",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V016"
}
]
}
]
},
{
"uniprot_ac": "Q3V129",
"gene_name": "Ulk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3V129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V129"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q3V129",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V129"
}
]
}
]
},
{
"uniprot_ac": "Q3V3A1",
"gene_name": "Cdk15",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q3V3A1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V3A1"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q3V3A1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V3A1"
}
]
}
]
},
{
"uniprot_ac": "Q4FZD7",
"gene_name": "Plk5",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4FZD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4FZD7"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q4FZD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4FZD7"
}
]
}
]
},
{
"uniprot_ac": "Q4G050",
"gene_name": "Mknk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4G050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4G050"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q4G050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4G050"
}
]
}
]
},
{
"uniprot_ac": "Q4KLN3",
"gene_name": "Srpk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4KLN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KLN3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q4KLN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KLN3"
}
]
}
]
},
{
"uniprot_ac": "Q4KM34",
"gene_name": "Cdk20",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4KM34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KM34"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q4KM34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KM34"
}
]
}
]
},
{
"uniprot_ac": "Q4KM47",
"gene_name": "Cdk10",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4KM47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KM47"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q4KM47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KM47"
}
]
}
]
},
{
"uniprot_ac": "Q4KSH6",
"gene_name": "Map2k4",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4KSH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KSH6"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q4KSH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KSH6"
}
]
}
]
},
{
"uniprot_ac": "Q4KSH7",
"gene_name": "Map2k7",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4KSH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KSH7"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q4KSH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4KSH7"
}
]
}
]
},
{
"uniprot_ac": "Q4V793",
"gene_name": "Hipk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4V793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4V793"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q4V793",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4V793"
}
]
}
]
},
{
"uniprot_ac": "Q4V8A3",
"gene_name": "Dyrk3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q4V8A3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4V8A3"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q4V8A3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q4V8A3"
}
]
}
]
},
{
"uniprot_ac": "Q52WX2",
"gene_name": "SBK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q52WX2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q52WX2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q52WX2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q52WX2"
}
]
}
]
},
{
"uniprot_ac": "Q53H12",
"gene_name": "AGK",
"activity": [
{
"ec_number": "2.7.1.107",
"activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).",
"evidence": [
{
"id": "Q53H12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53H12"
}
]
},
{
"ec_number": "2.7.1.94",
"activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.",
"evidence": [
{
"id": "Q53H12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53H12"
}
]
},
{
"ec_number": "2.7.1.138",
"activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).",
"evidence": [
{
"id": "Q53H12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53H12"
}
]
},
{
"ec_number": "2.7.1.107",
"activity": "",
"evidence": [
{
"id": "Q53H12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53H12"
}
]
},
{
"ec_number": "2.7.1.138",
"activity": "",
"evidence": [
{
"id": "Q53H12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53H12"
}
]
},
{
"ec_number": "2.7.1.94",
"activity": "",
"evidence": [
{
"id": "Q53H12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53H12"
}
]
}
]
},
{
"uniprot_ac": "Q53UA7",
"gene_name": "Taok3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q53UA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53UA7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q53UA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q53UA7"
}
]
}
]
},
{
"uniprot_ac": "Q54B33",
"gene_name": "pakE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54B33",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54B33"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54B33",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54B33"
}
]
}
]
},
{
"uniprot_ac": "Q54B48",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54B48",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54B48"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54B48",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54B48"
}
]
}
]
},
{
"uniprot_ac": "Q54BC9",
"gene_name": "dyrk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54BC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54BC9"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q54BC9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54BC9"
}
]
}
]
},
{
"uniprot_ac": "Q54BF0",
"gene_name": "fhkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54BF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54BF0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54BF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54BF0"
}
]
}
]
},
{
"uniprot_ac": "Q54C18",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54C18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C18"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54C18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C18"
}
]
}
]
},
{
"uniprot_ac": "Q54C38",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54C38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C38"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54C38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C38"
}
]
}
]
},
{
"uniprot_ac": "Q54C71",
"gene_name": "kxcB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54C71",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C71"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54C71",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C71"
}
]
}
]
},
{
"uniprot_ac": "Q54D75",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54D75",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54D75"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q54D75",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54D75"
}
]
}
]
},
{
"uniprot_ac": "Q54DC8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54DC8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DC8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54DC8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DC8"
}
]
}
]
},
{
"uniprot_ac": "Q54DF2",
"gene_name": "mrkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54DF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DF2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54DF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DF2"
}
]
}
]
},
{
"uniprot_ac": "Q54DK3",
"gene_name": "cdc7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54DK3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DK3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54DK3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DK3"
}
]
}
]
},
{
"uniprot_ac": "Q54DY0",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54DY0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DY0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54DY0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54DY0"
}
]
}
]
},
{
"uniprot_ac": "Q54E34",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54E34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54E34"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54E34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54E34"
}
]
}
]
},
{
"uniprot_ac": "Q54EG9",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54EG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EG9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54EG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EG9"
}
]
}
]
},
{
"uniprot_ac": "Q54EM1",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54EM1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EM1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54EM1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EM1"
}
]
}
]
},
{
"uniprot_ac": "Q54ER4",
"gene_name": "atr1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54ER4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ER4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54ER4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ER4"
}
]
}
]
},
{
"uniprot_ac": "Q54ET3",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54ET3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ET3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54ET3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ET3"
}
]
}
]
},
{
"uniprot_ac": "Q54EY4",
"gene_name": "dst3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54EY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EY4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54EY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54EY4"
}
]
}
]
},
{
"uniprot_ac": "Q54F40",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54F40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54F40"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54F40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54F40"
}
]
}
]
},
{
"uniprot_ac": "Q54FH3",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54FH3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54FH3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54FH3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54FH3"
}
]
}
]
},
{
"uniprot_ac": "Q54FR9",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54FR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54FR9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54FR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54FR9"
}
]
}
]
},
{
"uniprot_ac": "Q54G43",
"gene_name": "shkE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54G43",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54G43"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54G43",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54G43"
}
]
}
]
},
{
"uniprot_ac": "Q54GY6",
"gene_name": "kxcA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54GY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54GY6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54GY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54GY6"
}
]
}
]
},
{
"uniprot_ac": "Q54H05",
"gene_name": "kinY",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54H05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54H05"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54H05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54H05"
}
]
}
]
},
{
"uniprot_ac": "Q54H45",
"gene_name": "drkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54H45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54H45"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54H45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54H45"
}
]
}
]
},
{
"uniprot_ac": "Q54H46",
"gene_name": "drkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54H46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54H46"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54H46",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54H46"
}
]
}
]
},
{
"uniprot_ac": "Q54HC6",
"gene_name": "arkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54HC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HC6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54HC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HC6"
}
]
}
]
},
{
"uniprot_ac": "Q54HD2",
"gene_name": "ndrD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54HD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HD2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54HD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HD2"
}
]
}
]
},
{
"uniprot_ac": "Q54HS0",
"gene_name": "nek4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54HS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HS0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54HS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54HS0"
}
]
}
]
},
{
"uniprot_ac": "Q54I36",
"gene_name": "pyk3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54I36",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54I36"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q54I36",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54I36"
}
]
}
]
},
{
"uniprot_ac": "Q54IE8",
"gene_name": "irlE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54IE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IE8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54IE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IE8"
}
]
}
]
},
{
"uniprot_ac": "Q54IF2",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54IF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IF2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54IF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IF2"
}
]
}
]
},
{
"uniprot_ac": "Q54IH8",
"gene_name": "ndrB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54IH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54IH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IH8"
}
]
}
]
},
{
"uniprot_ac": "Q54IP4",
"gene_name": "shkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54IP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IP4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54IP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54IP4"
}
]
}
]
},
{
"uniprot_ac": "Q54JC7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54JC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54JC7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54JC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54JC7"
}
]
}
]
},
{
"uniprot_ac": "Q54JG7",
"gene_name": "dst4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54JG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54JG7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54JG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54JG7"
}
]
}
]
},
{
"uniprot_ac": "Q54JQ1",
"gene_name": "mkcC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54JQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54JQ1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54JQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54JQ1"
}
]
}
]
},
{
"uniprot_ac": "Q54L00",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54L00",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54L00"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54L00",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54L00"
}
]
}
]
},
{
"uniprot_ac": "Q54L81",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54L81",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54L81"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54L81",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54L81"
}
]
}
]
},
{
"uniprot_ac": "Q54LH8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54LH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54LH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LH8"
}
]
}
]
},
{
"uniprot_ac": "Q54LR6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54LR6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LR6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54LR6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LR6"
}
]
}
]
},
{
"uniprot_ac": "Q54LU8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54LU8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LU8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54LU8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54LU8"
}
]
}
]
},
{
"uniprot_ac": "Q54M77",
"gene_name": "roco8",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54M77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54M77"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54M77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54M77"
}
]
}
]
},
{
"uniprot_ac": "Q54MH0",
"gene_name": "fhkD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54MH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MH0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54MH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MH0"
}
]
}
]
},
{
"uniprot_ac": "Q54MV2",
"gene_name": "mrkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54MV2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MV2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54MV2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MV2"
}
]
}
]
},
{
"uniprot_ac": "Q54MY9",
"gene_name": "mkcA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54MY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MY9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54MY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54MY9"
}
]
}
]
},
{
"uniprot_ac": "Q54P26",
"gene_name": "samkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54P26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54P26"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54P26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54P26"
}
]
}
]
},
{
"uniprot_ac": "Q54P47",
"gene_name": "ndrC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54P47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54P47"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54P47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54P47"
}
]
}
]
},
{
"uniprot_ac": "Q54PK8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54PK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PK8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54PK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PK8"
}
]
}
]
},
{
"uniprot_ac": "Q54PK9",
"gene_name": "pdkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54PK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PK9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54PK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PK9"
}
]
}
]
},
{
"uniprot_ac": "Q54PX0",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54PX0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PX0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54PX0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54PX0"
}
]
}
]
},
{
"uniprot_ac": "Q54Q69",
"gene_name": "dhkG",
"activity": [
{
"ec_number": "2.7.13.3",
"activity": "ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.",
"evidence": [
{
"id": "Q54Q69",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Q69"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54Q69",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Q69"
}
]
}
]
},
{
"uniprot_ac": "Q54QB1",
"gene_name": "erkB",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54QB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QB1"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q54QB1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QB1"
}
]
}
]
},
{
"uniprot_ac": "Q54QD5",
"gene_name": "nek1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54QD5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QD5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54QD5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QD5"
}
]
}
]
},
{
"uniprot_ac": "Q54QI2",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54QI2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QI2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54QI2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QI2"
}
]
}
]
},
{
"uniprot_ac": "Q54QQ1",
"gene_name": "phg2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54QQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QQ1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54QQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QQ1"
}
]
}
]
},
{
"uniprot_ac": "Q54QV3",
"gene_name": "yakA",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54QV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QV3"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q54QV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54QV3"
}
]
}
]
},
{
"uniprot_ac": "Q54R82",
"gene_name": "mkkA",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54R82",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54R82"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q54R82",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54R82"
}
]
}
]
},
{
"uniprot_ac": "Q54R95",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54R95",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54R95"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54R95",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54R95"
}
]
}
]
},
{
"uniprot_ac": "Q54R98",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54R98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54R98"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54R98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54R98"
}
]
}
]
},
{
"uniprot_ac": "Q54RB2",
"gene_name": "cdk11",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RB2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RB2"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q54RB2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RB2"
}
]
}
]
},
{
"uniprot_ac": "Q54RB7",
"gene_name": "shkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RB7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RB7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54RB7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RB7"
}
]
}
]
},
{
"uniprot_ac": "Q54RJ4",
"gene_name": "iksA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RJ4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54RJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RJ4"
}
]
}
]
},
{
"uniprot_ac": "Q54RP7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RP7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54RP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RP7"
}
]
}
]
},
{
"uniprot_ac": "Q54RR9",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RR9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54RR9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RR9"
}
]
}
]
},
{
"uniprot_ac": "Q54RV3",
"gene_name": "pakG",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RV3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54RV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RV3"
}
]
}
]
},
{
"uniprot_ac": "Q54RZ7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54RZ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RZ7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54RZ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54RZ7"
}
]
}
]
},
{
"uniprot_ac": "Q54S77",
"gene_name": "vps15",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54S77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54S77"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54S77",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54S77"
}
]
}
]
},
{
"uniprot_ac": "Q54SC4",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54SC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54SC4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54SC4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54SC4"
}
]
}
]
},
{
"uniprot_ac": "Q54SK3",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54SK3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54SK3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54SK3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54SK3"
}
]
}
]
},
{
"uniprot_ac": "Q54T05",
"gene_name": "rio2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54T05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54T05"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54T05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54T05"
}
]
}
]
},
{
"uniprot_ac": "Q54TA1",
"gene_name": "drkC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54TA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TA1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54TA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TA1"
}
]
}
]
},
{
"uniprot_ac": "Q54TA3",
"gene_name": "mrkC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54TA3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TA3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54TA3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TA3"
}
]
}
]
},
{
"uniprot_ac": "Q54TH6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54TH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TH6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54TH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TH6"
}
]
}
]
},
{
"uniprot_ac": "Q54TM7",
"gene_name": "drkD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54TM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TM7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54TM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TM7"
}
]
}
]
},
{
"uniprot_ac": "Q54TN4",
"gene_name": "mkcE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54TN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TN4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54TN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TN4"
}
]
}
]
},
{
"uniprot_ac": "Q54TW2",
"gene_name": "pdkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54TW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TW2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54TW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54TW2"
}
]
}
]
},
{
"uniprot_ac": "Q54U31",
"gene_name": "shkD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54U31",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54U31"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54U31",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54U31"
}
]
}
]
},
{
"uniprot_ac": "Q54U65",
"gene_name": "7tmk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54U65",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54U65"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54U65",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54U65"
}
]
}
]
},
{
"uniprot_ac": "Q54UA9",
"gene_name": "clkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54UA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UA9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54UA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UA9"
}
]
}
]
},
{
"uniprot_ac": "Q54UC0",
"gene_name": "dnapkcs",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54UC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UC0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54UC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UC0"
}
]
}
]
},
{
"uniprot_ac": "Q54UL8",
"gene_name": "mps1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54UL8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UL8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54UL8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UL8"
}
]
}
]
},
{
"uniprot_ac": "Q54UZ1",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54UZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UZ1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54UZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54UZ1"
}
]
}
]
},
{
"uniprot_ac": "Q54V35",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54V35",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54V35"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54V35",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54V35"
}
]
}
]
},
{
"uniprot_ac": "Q54V83",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54V83",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54V83"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54V83",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54V83"
}
]
}
]
},
{
"uniprot_ac": "Q54VC0",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54VC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VC0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54VC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VC0"
}
]
}
]
},
{
"uniprot_ac": "Q54VD8",
"gene_name": "rio1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54VD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VD8"
}
]
},
{
"ec_number": "3.6.3.-",
"activity": "",
"evidence": [
{
"id": "Q54VD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VD8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54VD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VD8"
}
]
}
]
},
{
"uniprot_ac": "Q54VI1",
"gene_name": "fhkE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54VI1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VI1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54VI1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VI1"
}
]
}
]
},
{
"uniprot_ac": "Q54VU4",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54VU4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VU4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54VU4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VU4"
}
]
}
]
},
{
"uniprot_ac": "Q54VV7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54VV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VV7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54VV7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54VV7"
}
]
}
]
},
{
"uniprot_ac": "Q54W07",
"gene_name": "bud32",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54W07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54W07"
}
]
},
{
"ec_number": "3.6.-.-",
"activity": "",
"evidence": [
{
"id": "Q54W07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54W07"
}
]
}
]
},
{
"uniprot_ac": "Q54WC0",
"gene_name": "STK19",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WC0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WC0"
}
]
}
]
},
{
"uniprot_ac": "Q54WD7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WD7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WD7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WD7"
}
]
}
]
},
{
"uniprot_ac": "Q54WE5",
"gene_name": "prpf4B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WE5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WE5"
}
]
}
]
},
{
"uniprot_ac": "Q54WJ0",
"gene_name": "lkb1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WJ0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WJ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WJ0"
}
]
}
]
},
{
"uniprot_ac": "Q54WS5",
"gene_name": "roco6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WS5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WS5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WS5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WS5"
}
]
}
]
},
{
"uniprot_ac": "Q54WW7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WW7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WW7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WW7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WW7"
}
]
}
]
},
{
"uniprot_ac": "Q54WX4",
"gene_name": "aurK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54WX4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WX4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54WX4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54WX4"
}
]
}
]
},
{
"uniprot_ac": "Q54XJ4",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54XJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XJ4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54XJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XJ4"
}
]
}
]
},
{
"uniprot_ac": "Q54XL6",
"gene_name": "fray1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54XL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XL6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54XL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XL6"
}
]
}
]
},
{
"uniprot_ac": "Q54XQ2",
"gene_name": "rckA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XQ2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54XQ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XQ2"
}
]
}
]
},
{
"uniprot_ac": "Q54XX5",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54XX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XX5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54XX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XX5"
}
]
}
]
},
{
"uniprot_ac": "Q54XY6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54XY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XY6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54XY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XY6"
}
]
}
]
},
{
"uniprot_ac": "Q54XZ5",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54XZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XZ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54XZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54XZ5"
}
]
}
]
},
{
"uniprot_ac": "Q54Y06",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54Y06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y06"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q54Y06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y06"
}
]
}
]
},
{
"uniprot_ac": "Q54Y26",
"gene_name": "ndrA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54Y26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y26"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54Y26",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y26"
}
]
}
]
},
{
"uniprot_ac": "Q54Y55",
"gene_name": "shkC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54Y55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y55"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54Y55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y55"
}
]
}
]
},
{
"uniprot_ac": "Q54Y90",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54Y90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y90"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54Y90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54Y90"
}
]
}
]
},
{
"uniprot_ac": "Q54YF2",
"gene_name": "snfA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54YF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54YF2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54YF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54YF2"
}
]
}
]
},
{
"uniprot_ac": "Q54YZ5",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54YZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54YZ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54YZ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54YZ5"
}
]
}
]
},
{
"uniprot_ac": "Q54ZN3",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q54ZN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ZN3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q54ZN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54ZN3"
}
]
}
]
},
{
"uniprot_ac": "Q550K8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q550K8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q550K8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q550K8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q550K8"
}
]
}
]
},
{
"uniprot_ac": "Q550L8",
"gene_name": "ifkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q550L8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q550L8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q550L8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q550L8"
}
]
}
]
},
{
"uniprot_ac": "Q551H4",
"gene_name": "fray2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q551H4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q551H4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q551H4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q551H4"
}
]
}
]
},
{
"uniprot_ac": "Q552C1",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q552C1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552C1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q552C1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552C1"
}
]
}
]
},
{
"uniprot_ac": "Q552C6",
"gene_name": "zak2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q552C6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552C6"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q552C6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552C6"
}
]
}
]
},
{
"uniprot_ac": "Q552E9",
"gene_name": "pkgA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q552E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552E9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q552E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552E9"
}
]
}
]
},
{
"uniprot_ac": "Q552Z2",
"gene_name": "fnkE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q552Z2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552Z2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q552Z2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q552Z2"
}
]
}
]
},
{
"uniprot_ac": "Q553E9",
"gene_name": "smg1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q553E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q553E9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q553E9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q553E9"
}
]
}
]
},
{
"uniprot_ac": "Q556J6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q556J6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556J6"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q556J6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556J6"
}
]
}
]
},
{
"uniprot_ac": "Q556Q3",
"gene_name": "irlF-2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q556Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556Q3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q556Q3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556Q3"
}
]
}
]
},
{
"uniprot_ac": "Q556S2",
"gene_name": "pakH-2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q556S2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556S2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q556S2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556S2"
}
]
}
]
},
{
"uniprot_ac": "Q556Y4",
"gene_name": "cak1-1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q556Y4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556Y4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q556Y4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q556Y4"
}
]
}
]
},
{
"uniprot_ac": "Q557G1",
"gene_name": "irlB-1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q557G1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q557G1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q557G1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q557G1"
}
]
}
]
},
{
"uniprot_ac": "Q558U1",
"gene_name": "ifkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q558U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q558U1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q558U1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q558U1"
}
]
}
]
},
{
"uniprot_ac": "Q559A2",
"gene_name": "irlA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q559A2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q559A2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q559A2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q559A2"
}
]
}
]
},
{
"uniprot_ac": "Q559T8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q559T8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q559T8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q559T8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q559T8"
}
]
}
]
},
{
"uniprot_ac": "Q55A09",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55A09",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55A09"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55A09",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55A09"
}
]
}
]
},
{
"uniprot_ac": "Q55A55",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55A55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55A55"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55A55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55A55"
}
]
}
]
},
{
"uniprot_ac": "Q55BA0",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55BA0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55BA0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55BA0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55BA0"
}
]
}
]
},
{
"uniprot_ac": "Q55BN8",
"gene_name": "nek2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55BN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55BN8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55BN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55BN8"
}
]
}
]
},
{
"uniprot_ac": "Q55CA6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CA6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55CA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CA6"
}
]
}
]
},
{
"uniprot_ac": "Q55CE0",
"gene_name": "mkcF",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CE0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55CE0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CE0"
}
]
}
]
},
{
"uniprot_ac": "Q55CL6",
"gene_name": "mekA",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CL6"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q55CL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CL6"
}
]
}
]
},
{
"uniprot_ac": "Q55CW2",
"gene_name": "samkC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CW2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55CW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CW2"
}
]
}
]
},
{
"uniprot_ac": "Q55CW3",
"gene_name": "samkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CW3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CW3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55CW3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CW3"
}
]
}
]
},
{
"uniprot_ac": "Q55CY9",
"gene_name": "gdt8",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CY9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55CY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CY9"
}
]
}
]
},
{
"uniprot_ac": "Q55CZ1",
"gene_name": "gdt2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55CZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CZ1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55CZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55CZ1"
}
]
}
]
},
{
"uniprot_ac": "Q55D99",
"gene_name": "pakA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55D99",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55D99"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55D99",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55D99"
}
]
}
]
},
{
"uniprot_ac": "Q55DD4",
"gene_name": "pakD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55DD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DD4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55DD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DD4"
}
]
}
]
},
{
"uniprot_ac": "Q55DJ8",
"gene_name": "irlC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55DJ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DJ8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55DJ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DJ8"
}
]
}
]
},
{
"uniprot_ac": "Q55DJ9",
"gene_name": "irlD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55DJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DJ9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55DJ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DJ9"
}
]
}
]
},
{
"uniprot_ac": "Q55DK2",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55DK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DK2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55DK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DK2"
}
]
}
]
},
{
"uniprot_ac": "Q55DU7",
"gene_name": "gdt4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55DU7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DU7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55DU7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55DU7"
}
]
}
]
},
{
"uniprot_ac": "Q55E58",
"gene_name": "pats1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55E58",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55E58"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55E58",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55E58"
}
]
}
]
},
{
"uniprot_ac": "Q55EC7",
"gene_name": "gefX",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55EC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55EC7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55EC7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55EC7"
}
]
}
]
},
{
"uniprot_ac": "Q55EI8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55EI8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55EI8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55EI8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55EI8"
}
]
}
]
},
{
"uniprot_ac": "Q55F45",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55F45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55F45"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55F45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55F45"
}
]
}
]
},
{
"uniprot_ac": "Q55FJ6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55FJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FJ6"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q55FJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FJ6"
}
]
}
]
},
{
"uniprot_ac": "Q55FS2",
"gene_name": "krsB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55FS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FS2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55FS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FS2"
}
]
}
]
},
{
"uniprot_ac": "Q55FT4",
"gene_name": "tsuA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55FT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FT4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55FT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FT4"
}
]
}
]
},
{
"uniprot_ac": "Q55FV4",
"gene_name": "fnkB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55FV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FV4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55FV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FV4"
}
]
}
]
},
{
"uniprot_ac": "Q55FV5",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55FV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FV5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55FV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55FV5"
}
]
}
]
},
{
"uniprot_ac": "Q55GC2",
"gene_name": "dst2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GC2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55GC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GC2"
}
]
}
]
},
{
"uniprot_ac": "Q55GE6",
"gene_name": "roco7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GE6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55GE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GE6"
}
]
}
]
},
{
"uniprot_ac": "Q55GG4",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GG4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GG4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55GG4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GG4"
}
]
}
]
},
{
"uniprot_ac": "Q55GJ2",
"gene_name": "ireA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GJ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GJ2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55GJ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GJ2"
}
]
}
]
},
{
"uniprot_ac": "Q55GS4",
"gene_name": "cdk10",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GS4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q55GS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GS4"
}
]
}
]
},
{
"uniprot_ac": "Q55GU0",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GU0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55GU0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GU0"
}
]
}
]
},
{
"uniprot_ac": "Q55GV3",
"gene_name": "pakC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q55GV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GV3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q55GV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q55GV3"
}
]
}
]
},
{
"uniprot_ac": "Q56UN5",
"gene_name": "MAP3K19",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q56UN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q56UN5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q56UN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q56UN5"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q56UN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q56UN5"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q56UN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q56UN5"
}
]
}
]
},
{
"uniprot_ac": "Q59H18",
"gene_name": "TNNI3K",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q59H18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q59H18"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q59H18",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q59H18"
}
]
}
]
},
{
"uniprot_ac": "Q5EAK6",
"gene_name": "tefu",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5EAK6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EAK6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5EAK6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EAK6"
}
]
}
]
},
{
"uniprot_ac": "Q5EG47",
"gene_name": "Prkaa1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5EG47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EG47"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "Q5EG47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EG47"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "",
"evidence": [
{
"id": "Q5EG47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EG47"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5EG47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EG47"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q5EG47",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5EG47"
}
]
}
]
},
{
"uniprot_ac": "Q5F2E8",
"gene_name": "Taok1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5F2E8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5F2E8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5F2E8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5F2E8"
}
]
}
]
},
{
"uniprot_ac": "Q5GIG6",
"gene_name": "Tnni3k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5GIG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5GIG6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5GIG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5GIG6"
}
]
}
]
},
{
"uniprot_ac": "Q5MAI5",
"gene_name": "CDKL4",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5MAI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5MAI5"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q5MAI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5MAI5"
}
]
}
]
},
{
"uniprot_ac": "Q5MJS3",
"gene_name": "Fam20c",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5MJS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5MJS3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5MJS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5MJS3"
}
]
}
]
},
{
"uniprot_ac": "Q5MPA9",
"gene_name": "Dclk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5MPA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5MPA9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5MPA9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5MPA9"
}
]
}
]
},
{
"uniprot_ac": "Q5PQT0",
"gene_name": "Pask",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5PQT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5PQT0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5PQT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5PQT0"
}
]
}
]
},
{
"uniprot_ac": "Q5RJI5",
"gene_name": "Brsk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5RJI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RJI5"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q5RJI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RJI5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5RJI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RJI5"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q5RJI5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RJI5"
}
]
}
]
},
{
"uniprot_ac": "Q5RKH1",
"gene_name": "Prpf4b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5RKH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKH1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5RKH1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5RKH1"
}
]
}
]
},
{
"uniprot_ac": "Q5S006",
"gene_name": "Lrrk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5S006",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5S006"
}
]
},
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "Q5S006",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5S006"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5S006",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5S006"
}
]
}
]
},
{
"uniprot_ac": "Q5S007",
"gene_name": "LRRK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5S007",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5S007"
}
]
},
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "Q5S007",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5S007"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5S007",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5S007"
}
]
}
]
},
{
"uniprot_ac": "Q5SUV5",
"gene_name": "Mylk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5SUV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5SUV5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5SUV5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5SUV5"
}
]
}
]
},
{
"uniprot_ac": "Q5SYL1",
"gene_name": "Rskr",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5SYL1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5SYL1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5SYL1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5SYL1"
}
]
}
]
},
{
"uniprot_ac": "Q5TCX8",
"gene_name": "MAP3K21",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5TCX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5TCX8"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q5TCX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5TCX8"
}
]
}
]
},
{
"uniprot_ac": "Q5TCY1",
"gene_name": "TTBK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5TCY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5TCY1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5TCY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5TCY1"
}
]
}
]
},
{
"uniprot_ac": "Q5U2N4",
"gene_name": "Mknk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5U2N4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U2N4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5U2N4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U2N4"
}
]
}
]
},
{
"uniprot_ac": "Q5U2X5",
"gene_name": "Tnk2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q5U2X5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U2X5"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "Q5U2X5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U2X5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5U2X5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U2X5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5U2X5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U2X5"
}
]
}
]
},
{
"uniprot_ac": "Q5U452",
"gene_name": "Trp53rka",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5U452",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U452"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5U452",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U452"
}
]
}
]
},
{
"uniprot_ac": "Q5U4C9",
"gene_name": "Dyrk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5U4C9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U4C9"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q5U4C9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5U4C9"
}
]
}
]
},
{
"uniprot_ac": "Q5VJL3",
"gene_name": "gdt9",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5VJL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VJL3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5VJL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VJL3"
}
]
}
]
},
{
"uniprot_ac": "Q5VST9",
"gene_name": "OBSCN",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5VST9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VST9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5VST9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VST9"
}
]
}
]
},
{
"uniprot_ac": "Q5VT25",
"gene_name": "CDC42BPA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5VT25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VT25"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5VT25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5VT25"
}
]
}
]
},
{
"uniprot_ac": "Q5XG87",
"gene_name": "TENT4A",
"activity": [
{
"ec_number": "2.7.7.-",
"activity": "",
"evidence": [
{
"id": "Q5XG87",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XG87"
}
]
},
{
"ec_number": "2.7.7.19",
"activity": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide.",
"evidence": [
{
"id": "Q5XG87",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XG87"
}
]
}
]
},
{
"uniprot_ac": "Q5XIS9",
"gene_name": "Prkd2",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5XIS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XIS9"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q5XIS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XIS9"
}
]
}
]
},
{
"uniprot_ac": "Q5XIT0",
"gene_name": "Cdkl2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5XIT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XIT0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q5XIT0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XIT0"
}
]
}
]
},
{
"uniprot_ac": "Q5XJV6",
"gene_name": "Lmtk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q5XJV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XJV6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q5XJV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q5XJV6"
}
]
}
]
},
{
"uniprot_ac": "Q60592",
"gene_name": "Mast2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60592",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60592"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q60592",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60592"
}
]
}
]
},
{
"uniprot_ac": "Q60670",
"gene_name": "Sik1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60670"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q60670",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60670"
}
]
}
]
},
{
"uniprot_ac": "Q60700",
"gene_name": "Map3k12",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60700",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60700"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q60700",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60700"
}
]
}
]
},
{
"uniprot_ac": "Q60737",
"gene_name": "Csnk2a1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60737",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60737"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q60737",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60737"
}
]
}
]
},
{
"uniprot_ac": "Q60806",
"gene_name": "Plk3",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60806",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60806"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q60806",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60806"
}
]
}
]
},
{
"uniprot_ac": "Q60823",
"gene_name": "Akt2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60823",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60823"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q60823",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60823"
}
]
}
]
},
{
"uniprot_ac": "Q60855",
"gene_name": "Ripk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q60855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60855"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q60855",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q60855"
}
]
}
]
},
{
"uniprot_ac": "Q61036",
"gene_name": "Pak3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61036",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61036"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q61036",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61036"
}
]
}
]
},
{
"uniprot_ac": "Q61083",
"gene_name": "Map3k2",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61083",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61083"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q61083",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61083"
}
]
}
]
},
{
"uniprot_ac": "Q61084",
"gene_name": "Map3k3",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61084",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61084"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q61084",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61084"
}
]
}
]
},
{
"uniprot_ac": "Q61097",
"gene_name": "Ksr1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61097",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61097"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q61097",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61097"
}
]
}
]
},
{
"uniprot_ac": "Q61136",
"gene_name": "Prpf4b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61136",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61136"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q61136",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61136"
}
]
}
]
},
{
"uniprot_ac": "Q61161",
"gene_name": "Map4k2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61161",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61161"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q61161",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61161"
}
]
}
]
},
{
"uniprot_ac": "Q61214",
"gene_name": "Dyrk1a",
"activity": [
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q61214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61214"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61214"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q61214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61214"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q61214",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61214"
}
]
}
]
},
{
"uniprot_ac": "Q61241",
"gene_name": "Tssk1b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61241"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q61241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61241"
}
]
}
]
},
{
"uniprot_ac": "Q61410",
"gene_name": "Prkg2",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61410",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61410"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q61410",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61410"
}
]
}
]
},
{
"uniprot_ac": "Q61532",
"gene_name": "Mapk6",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61532"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q61532",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61532"
}
]
}
]
},
{
"uniprot_ac": "Q61831",
"gene_name": "Mapk10",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61831"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q61831",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61831"
}
]
}
]
},
{
"uniprot_ac": "Q61846",
"gene_name": "Melk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q61846",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61846"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q61846",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61846"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q61846",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61846"
}
]
}
]
},
{
"uniprot_ac": "Q62070",
"gene_name": "Pim2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62070"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62070"
}
]
}
]
},
{
"uniprot_ac": "Q62073",
"gene_name": "Map3k7",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62073",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62073"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q62073",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62073"
}
]
}
]
},
{
"uniprot_ac": "Q62074",
"gene_name": "Prkci",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62074"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q62074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62074"
}
]
}
]
},
{
"uniprot_ac": "Q62101",
"gene_name": "Prkd1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62101",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62101"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q62101",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62101"
}
]
}
]
},
{
"uniprot_ac": "Q62388",
"gene_name": "Atm",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62388",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62388"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62388",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62388"
}
]
}
]
},
{
"uniprot_ac": "Q62406",
"gene_name": "Irak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62406",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62406"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62406",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62406"
}
]
}
]
},
{
"uniprot_ac": "Q62407",
"gene_name": "Speg",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62407",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62407"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62407",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62407"
}
]
}
]
},
{
"uniprot_ac": "Q62673",
"gene_name": "Plk1",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62673",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62673"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q62673",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62673"
}
]
}
]
},
{
"uniprot_ac": "Q62726",
"gene_name": "Cilk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62726",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62726"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62726",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62726"
}
]
}
]
},
{
"uniprot_ac": "Q62761",
"gene_name": "Csnk1g1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62761"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62761",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62761"
}
]
}
]
},
{
"uniprot_ac": "Q62762",
"gene_name": "Csnk1g2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62762"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62762",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62762"
}
]
}
]
},
{
"uniprot_ac": "Q62763",
"gene_name": "Csnk1g3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62763",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62763"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62763",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62763"
}
]
}
]
},
{
"uniprot_ac": "Q62829",
"gene_name": "Pak3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62829",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62829"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62829",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62829"
}
]
}
]
},
{
"uniprot_ac": "Q62862",
"gene_name": "Map2k5",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62862",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62862"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q62862",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62862"
}
]
}
]
},
{
"uniprot_ac": "Q62868",
"gene_name": "Rock2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62868",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62868"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62868",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62868"
}
]
}
]
},
{
"uniprot_ac": "Q62915",
"gene_name": "Cask",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62915",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62915"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q62915",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62915"
}
]
}
]
},
{
"uniprot_ac": "Q62925",
"gene_name": "Map3k1",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q62925",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62925"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q62925",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q62925"
}
]
}
]
},
{
"uniprot_ac": "Q63117",
"gene_name": "Clk3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63117",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63117"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q63117",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63117"
}
]
}
]
},
{
"uniprot_ac": "Q63184",
"gene_name": "Eif2ak2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q63184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63184"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63184"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63184",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63184"
}
]
}
]
},
{
"uniprot_ac": "Q63185",
"gene_name": "Eif2ak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63185"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63185",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63185"
}
]
}
]
},
{
"uniprot_ac": "Q63285",
"gene_name": "Uhmk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63285"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63285",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63285"
}
]
}
]
},
{
"uniprot_ac": "Q63433",
"gene_name": "Pkn1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63433",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63433"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q63433",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63433"
}
]
}
]
},
{
"uniprot_ac": "Q63450",
"gene_name": "Camk1",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63450",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63450"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q63450",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63450"
}
]
}
]
},
{
"uniprot_ac": "Q63454",
"gene_name": "Mapk4",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63454"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q63454",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63454"
}
]
}
]
},
{
"uniprot_ac": "Q63470",
"gene_name": "Dyrk1a",
"activity": [
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q63470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63470"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63470"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q63470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63470"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q63470",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63470"
}
]
}
]
},
{
"uniprot_ac": "Q63484",
"gene_name": "Akt3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63484",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63484"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63484",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63484"
}
]
}
]
},
{
"uniprot_ac": "Q63531",
"gene_name": "Rps6ka1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63531",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63531"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63531",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63531"
}
]
}
]
},
{
"uniprot_ac": "Q63538",
"gene_name": "Mapk12",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63538"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q63538",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63538"
}
]
}
]
},
{
"uniprot_ac": "Q63553",
"gene_name": "Snrk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63553",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63553"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63553",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63553"
}
]
}
]
},
{
"uniprot_ac": "Q63562",
"gene_name": "Map3k8",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63562"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q63562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63562"
}
]
}
]
},
{
"uniprot_ac": "Q63572",
"gene_name": "Tesk1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63572"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q63572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63572"
}
]
}
]
},
{
"uniprot_ac": "Q63638",
"gene_name": "Speg",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63638",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63638"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63638",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63638"
}
]
}
]
},
{
"uniprot_ac": "Q63644",
"gene_name": "Rock1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63644"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q63644",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63644"
}
]
}
]
},
{
"uniprot_ac": "Q63686",
"gene_name": "Cdk16",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63686",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63686"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q63686",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63686"
}
]
}
]
},
{
"uniprot_ac": "Q63699",
"gene_name": "Cdk2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63699",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63699"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q63699",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63699"
}
]
}
]
},
{
"uniprot_ac": "Q63796",
"gene_name": "Map3k12",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63796",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63796"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q63796",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63796"
}
]
}
]
},
{
"uniprot_ac": "Q63844",
"gene_name": "Mapk3",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63844"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q63844",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63844"
}
]
}
]
},
{
"uniprot_ac": "Q63932",
"gene_name": "Map2k2",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63932",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63932"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q63932",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63932"
}
]
}
]
},
{
"uniprot_ac": "Q63945",
"gene_name": "Set",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q63945",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63945"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q63945",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63945"
}
]
}
]
},
{
"uniprot_ac": "Q641K5",
"gene_name": "Nuak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q641K5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641K5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q641K5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641K5"
}
]
}
]
},
{
"uniprot_ac": "Q641Z4",
"gene_name": "Cdk9",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q641Z4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641Z4"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q641Z4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641Z4"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q641Z4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641Z4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q641Z4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q641Z4"
}
]
}
]
},
{
"uniprot_ac": "Q64261",
"gene_name": "Cdk6",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q64261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64261"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q64261",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64261"
}
]
}
]
},
{
"uniprot_ac": "Q64303",
"gene_name": "Pak2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q64303",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64303"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q64303",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64303"
}
]
}
]
},
{
"uniprot_ac": "Q64595",
"gene_name": "Prkg2",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q64595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64595"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q64595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64595"
}
]
}
]
},
{
"uniprot_ac": "Q64617",
"gene_name": "Prkch",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q64617",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64617"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q64617",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64617"
}
]
}
]
},
{
"uniprot_ac": "Q64702",
"gene_name": "Plk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q64702",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64702"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q64702",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64702"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q64702",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64702"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q64702",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q64702"
}
]
}
]
},
{
"uniprot_ac": "Q66H84",
"gene_name": "Mapkapk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q66H84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66H84"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q66H84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66H84"
}
]
}
]
},
{
"uniprot_ac": "Q66HA1",
"gene_name": "Map3k11",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q66HA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HA1"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q66HA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HA1"
}
]
}
]
},
{
"uniprot_ac": "Q66HE5",
"gene_name": "Nuak2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q66HE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HE5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q66HE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HE5"
}
]
}
]
},
{
"uniprot_ac": "Q66HE7",
"gene_name": "Cdkl1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q66HE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HE7"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q66HE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66HE7"
}
]
}
]
},
{
"uniprot_ac": "Q66L42",
"gene_name": "Map3k10",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q66L42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66L42"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q66L42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q66L42"
}
]
}
]
},
{
"uniprot_ac": "Q69Z98",
"gene_name": "Brsk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q69Z98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69Z98"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q69Z98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69Z98"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q69Z98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69Z98"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q69Z98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69Z98"
}
]
}
]
},
{
"uniprot_ac": "Q69ZA1",
"gene_name": "Cdk13",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q69ZA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZA1"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q69ZA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZA1"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q69ZA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZA1"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q69ZA1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZA1"
}
]
}
]
},
{
"uniprot_ac": "Q69ZM6",
"gene_name": "Stk36",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q69ZM6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZM6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q69ZM6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q69ZM6"
}
]
}
]
},
{
"uniprot_ac": "Q6A1A2",
"gene_name": "PDPK2P",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6A1A2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6A1A2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6A1A2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6A1A2"
}
]
}
]
},
{
"uniprot_ac": "Q6B9X6",
"gene_name": "vwkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6B9X6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6B9X6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6B9X6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6B9X6"
}
]
}
]
},
{
"uniprot_ac": "Q6DT37",
"gene_name": "CDC42BPG",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6DT37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6DT37"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6DT37",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6DT37"
}
]
}
]
},
{
"uniprot_ac": "Q6IQ55",
"gene_name": "TTBK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6IQ55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6IQ55"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6IQ55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6IQ55"
}
]
}
]
},
{
"uniprot_ac": "Q6P0Q8",
"gene_name": "MAST2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P0Q8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P0Q8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6P0Q8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P0Q8"
}
]
}
]
},
{
"uniprot_ac": "Q6P2M8",
"gene_name": "PNCK",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P2M8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P2M8"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q6P2M8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P2M8"
}
]
}
]
},
{
"uniprot_ac": "Q6P3R8",
"gene_name": "NEK5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P3R8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3R8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6P3R8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P3R8"
}
]
}
]
},
{
"uniprot_ac": "Q6P4S6",
"gene_name": "Sik3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P4S6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P4S6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6P4S6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P4S6"
}
]
}
]
},
{
"uniprot_ac": "Q6P5G0",
"gene_name": "Mapk4",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P5G0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5G0"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q6P5G0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5G0"
}
]
}
]
},
{
"uniprot_ac": "Q6P5Z2",
"gene_name": "PKN3",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P5Z2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5Z2"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q6P5Z2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P5Z2"
}
]
}
]
},
{
"uniprot_ac": "Q6P9R2",
"gene_name": "Oxsr1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6P9R2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P9R2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6P9R2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P9R2"
}
]
}
]
},
{
"uniprot_ac": "Q6PAJ1",
"gene_name": "Bcr",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6PAJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PAJ1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6PAJ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PAJ1"
}
]
}
]
},
{
"uniprot_ac": "Q6PCN3",
"gene_name": "Ttbk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6PCN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PCN3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6PCN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PCN3"
}
]
}
]
},
{
"uniprot_ac": "Q6PGN3",
"gene_name": "Dclk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6PGN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PGN3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6PGN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PGN3"
}
]
}
]
},
{
"uniprot_ac": "Q6PHR2",
"gene_name": "ULK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6PHR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PHR2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6PHR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PHR2"
}
]
}
]
},
{
"uniprot_ac": "Q6PHZ2",
"gene_name": "Camk2d",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6PHZ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PHZ2"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q6PHZ2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6PHZ2"
}
]
}
]
},
{
"uniprot_ac": "Q6SA08",
"gene_name": "TSSK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6SA08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6SA08"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6SA08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6SA08"
}
]
}
]
},
{
"uniprot_ac": "Q6V9V9",
"gene_name": "Stk25",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6V9V9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V9V9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6V9V9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V9V9"
}
]
}
]
},
{
"uniprot_ac": "Q6V9Y2",
"gene_name": "Tssk1b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6V9Y2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V9Y2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6V9Y2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V9Y2"
}
]
}
]
},
{
"uniprot_ac": "Q6V9Y3",
"gene_name": "Tssk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6V9Y3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V9Y3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6V9Y3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6V9Y3"
}
]
}
]
},
{
"uniprot_ac": "Q6VAB6",
"gene_name": "KSR2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6VAB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6VAB6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6VAB6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6VAB6"
}
]
}
]
},
{
"uniprot_ac": "Q6XHA5",
"gene_name": "roco11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6XHA5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XHA5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6XHA5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XHA5"
}
]
}
]
},
{
"uniprot_ac": "Q6XHA7",
"gene_name": "roco9",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6XHA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XHA7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6XHA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XHA7"
}
]
}
]
},
{
"uniprot_ac": "Q6XHB2",
"gene_name": "roco4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6XHB2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XHB2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6XHB2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XHB2"
}
]
}
]
},
{
"uniprot_ac": "Q6XUX1",
"gene_name": "Dstyk",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6XUX1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XUX1"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q6XUX1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XUX1"
}
]
}
]
},
{
"uniprot_ac": "Q6XUX2",
"gene_name": "Dstyk",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6XUX2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XUX2"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q6XUX2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XUX2"
}
]
}
]
},
{
"uniprot_ac": "Q6XUX3",
"gene_name": "DSTYK",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6XUX3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XUX3"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q6XUX3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6XUX3"
}
]
}
]
},
{
"uniprot_ac": "Q6ZMQ8",
"gene_name": "AATK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6ZMQ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZMQ8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6ZMQ8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZMQ8"
}
]
}
]
},
{
"uniprot_ac": "Q6ZMT4",
"gene_name": "KDM7A",
"activity": [
{
"ec_number": "1.14.11.65",
"activity": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate.",
"evidence": [
{
"id": "Q6ZMT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZMT4"
}
]
}
]
},
{
"uniprot_ac": "Q6ZN16",
"gene_name": "MAP3K15",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6ZN16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZN16"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q6ZN16",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZN16"
}
]
}
]
},
{
"uniprot_ac": "Q6ZQ29",
"gene_name": "Taok2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6ZQ29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZQ29"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6ZQ29",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZQ29"
}
]
}
]
},
{
"uniprot_ac": "Q6ZWH5",
"gene_name": "NEK10",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q6ZWH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZWH5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q6ZWH5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6ZWH5"
}
]
}
]
},
{
"uniprot_ac": "Q70PP2",
"gene_name": "nonC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q70PP2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q70PP2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q70PP2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q70PP2"
}
]
}
]
},
{
"uniprot_ac": "Q75JK0",
"gene_name": "zakA",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q75JK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JK0"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q75JK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JK0"
}
]
}
]
},
{
"uniprot_ac": "Q75JN1",
"gene_name": "ifkC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q75JN1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JN1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q75JN1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q75JN1"
}
]
}
]
},
{
"uniprot_ac": "Q76MJ5",
"gene_name": "ERN2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q76MJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76MJ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q76MJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76MJ5"
}
]
},
{
"ec_number": "3.1.26.-",
"activity": "",
"evidence": [
{
"id": "Q76MJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76MJ5"
}
]
}
]
},
{
"uniprot_ac": "Q76NV1",
"gene_name": "dyrk1",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q76NV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76NV1"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q76NV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76NV1"
}
]
}
]
},
{
"uniprot_ac": "Q76P07",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q76P07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76P07"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q76P07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q76P07"
}
]
}
]
},
{
"uniprot_ac": "Q7KRY6",
"gene_name": "ball",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7KRY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KRY6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7KRY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KRY6"
}
]
}
]
},
{
"uniprot_ac": "Q7KZF4",
"gene_name": "SND1",
"activity": [
{
"ec_number": "3.1.31.1",
"activity": "Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.",
"evidence": [
{
"id": "Q7KZF4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KZF4"
}
]
},
{
"ec_number": "3.1.31.1",
"activity": "",
"evidence": [
{
"id": "Q7KZF4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KZF4"
}
]
}
]
},
{
"uniprot_ac": "Q7KZI7",
"gene_name": "MARK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7KZI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KZI7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7KZI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KZI7"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q7KZI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KZI7"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q7KZI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KZI7"
}
]
}
]
},
{
"uniprot_ac": "Q7L7X3",
"gene_name": "TAOK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7L7X3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L7X3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7L7X3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7L7X3"
}
]
}
]
},
{
"uniprot_ac": "Q7PLI7",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7PLI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7PLI7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7PLI7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7PLI7"
}
]
}
]
},
{
"uniprot_ac": "Q7TNJ7",
"gene_name": "Camk1g",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TNJ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TNJ7"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q7TNJ7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TNJ7"
}
]
}
]
},
{
"uniprot_ac": "Q7TNL3",
"gene_name": "Stk40",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TNL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TNL3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TNL3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TNL3"
}
]
}
]
},
{
"uniprot_ac": "Q7TNL4",
"gene_name": "Stk40",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TNL4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TNL4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TNL4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TNL4"
}
]
}
]
},
{
"uniprot_ac": "Q7TPK6",
"gene_name": "Wnk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TPK6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TPK6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TPK6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TPK6"
}
]
}
]
},
{
"uniprot_ac": "Q7TPS0",
"gene_name": "Rps6ka6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TPS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TPS0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TPS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TPS0"
}
]
}
]
},
{
"uniprot_ac": "Q7TQP6",
"gene_name": "Tnni3k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TQP6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TQP6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TQP6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TQP6"
}
]
}
]
},
{
"uniprot_ac": "Q7TSC3",
"gene_name": "Nek5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TSC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TSC3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TSC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TSC3"
}
]
}
]
},
{
"uniprot_ac": "Q7TSE6",
"gene_name": "Stk38l",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TSE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TSE6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TSE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TSE6"
}
]
}
]
},
{
"uniprot_ac": "Q7TSJ6",
"gene_name": "Lats2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TSJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TSJ6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TSJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TSJ6"
}
]
}
]
},
{
"uniprot_ac": "Q7TT49",
"gene_name": "Cdc42bpb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TT49",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TT49"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TT49",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TT49"
}
]
}
]
},
{
"uniprot_ac": "Q7TT50",
"gene_name": "Cdc42bpb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7TT50",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TT50"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7TT50",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7TT50"
}
]
}
]
},
{
"uniprot_ac": "Q7Z2Y5",
"gene_name": "NRK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q7Z2Y5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z2Y5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q7Z2Y5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z2Y5"
}
]
}
]
},
{
"uniprot_ac": "Q7Z569",
"gene_name": "BRAP",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q7Z569",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z569"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "Q7Z569",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7Z569"
}
]
}
]
},
{
"uniprot_ac": "Q80TR8",
"gene_name": "Dcaf1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80TR8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80TR8"
}
]
}
]
},
{
"uniprot_ac": "Q80UE6",
"gene_name": "Wnk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80UE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UE6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80UE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UE6"
}
]
}
]
},
{
"uniprot_ac": "Q80UV9",
"gene_name": "Taf1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80UV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UV9"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].",
"evidence": [
{
"id": "Q80UV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UV9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80UV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UV9"
}
]
},
{
"ec_number": "2.3.1.48",
"activity": "",
"evidence": [
{
"id": "Q80UV9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UV9"
}
]
}
]
},
{
"uniprot_ac": "Q80UW5",
"gene_name": "Cdc42bpg",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80UW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UW5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80UW5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80UW5"
}
]
}
]
},
{
"uniprot_ac": "Q80X41",
"gene_name": "Vrk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80X41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80X41"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80X41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80X41"
}
]
}
]
},
{
"uniprot_ac": "Q80XI6",
"gene_name": "Map3k11",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80XI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80XI6"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q80XI6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80XI6"
}
]
}
]
},
{
"uniprot_ac": "Q80XP9",
"gene_name": "Wnk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80XP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80XP9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80XP9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80XP9"
}
]
}
]
},
{
"uniprot_ac": "Q80Y86",
"gene_name": "Mapk15",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80Y86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80Y86"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q80Y86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80Y86"
}
]
}
]
},
{
"uniprot_ac": "Q80YE4",
"gene_name": "Aatk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80YE4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YE4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80YE4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YE4"
}
]
}
]
},
{
"uniprot_ac": "Q80YE7",
"gene_name": "Dapk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80YE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YE7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q80YE7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YE7"
}
]
}
]
},
{
"uniprot_ac": "Q80YP0",
"gene_name": "Cdk3",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80YP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YP0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q80YP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80YP0"
}
]
}
]
},
{
"uniprot_ac": "Q80ZW0",
"gene_name": "Stk35",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q80ZW0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q80ZW0"
}
]
}
]
},
{
"uniprot_ac": "Q810W7",
"gene_name": "Mast1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q810W7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q810W7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q810W7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q810W7"
}
]
}
]
},
{
"uniprot_ac": "Q811L6",
"gene_name": "Mast4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q811L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q811L6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q811L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q811L6"
}
]
}
]
},
{
"uniprot_ac": "Q869L4",
"gene_name": "fnkA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q869L4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869L4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q869L4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869L4"
}
]
}
]
},
{
"uniprot_ac": "Q869N2",
"gene_name": "pakB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q869N2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869N2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q869N2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869N2"
}
]
}
]
},
{
"uniprot_ac": "Q869T7",
"gene_name": "pakF",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q869T7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869T7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q869T7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869T7"
}
]
}
]
},
{
"uniprot_ac": "Q869X3",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q869X3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869X3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q869X3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q869X3"
}
]
}
]
},
{
"uniprot_ac": "Q86A12",
"gene_name": "sky1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86A12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86A12"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86A12",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86A12"
}
]
}
]
},
{
"uniprot_ac": "Q86AE1",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86AE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86AE1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86AE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86AE1"
}
]
}
]
},
{
"uniprot_ac": "Q86AT8",
"gene_name": "spkA-1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86AT8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86AT8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86AT8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86AT8"
}
]
}
]
},
{
"uniprot_ac": "Q86C65",
"gene_name": "tor",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86C65",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86C65"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86C65",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86C65"
}
]
}
]
},
{
"uniprot_ac": "Q86CS2",
"gene_name": "atg1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86CS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86CS2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86CS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86CS2"
}
]
}
]
},
{
"uniprot_ac": "Q86HG9",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86HG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86HG9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86HG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86HG9"
}
]
}
]
},
{
"uniprot_ac": "Q86HN7",
"gene_name": "PLK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86HN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86HN7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86HN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86HN7"
}
]
}
]
},
{
"uniprot_ac": "Q86HW6",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86HW6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86HW6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86HW6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86HW6"
}
]
}
]
},
{
"uniprot_ac": "Q86I06",
"gene_name": "nek3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86I06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86I06"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86I06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86I06"
}
]
}
]
},
{
"uniprot_ac": "Q86IX1",
"gene_name": "dst1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86IX1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86IX1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86IX1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86IX1"
}
]
}
]
},
{
"uniprot_ac": "Q86SG6",
"gene_name": "NEK8",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86SG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86SG6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86SG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86SG6"
}
]
}
]
},
{
"uniprot_ac": "Q86TB3",
"gene_name": "ALPK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86TB3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86TB3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86TB3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86TB3"
}
]
}
]
},
{
"uniprot_ac": "Q86UE8",
"gene_name": "TLK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86UE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86UE8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86UE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86UE8"
}
]
}
]
},
{
"uniprot_ac": "Q86UX6",
"gene_name": "STK32C",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86UX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86UX6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86UX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86UX6"
}
]
}
]
},
{
"uniprot_ac": "Q86V86",
"gene_name": "PIM3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86V86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86V86"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86V86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86V86"
}
]
}
]
},
{
"uniprot_ac": "Q86Y07",
"gene_name": "VRK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86Y07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Y07"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86Y07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Y07"
}
]
}
]
},
{
"uniprot_ac": "Q86YV6",
"gene_name": "MYLK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86YV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86YV6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86YV6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86YV6"
}
]
}
]
},
{
"uniprot_ac": "Q86Z02",
"gene_name": "HIPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q86Z02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Z02"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q86Z02",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q86Z02"
}
]
}
]
},
{
"uniprot_ac": "Q8BG48",
"gene_name": "Stk17b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BG48",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BG48"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BG48",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BG48"
}
]
}
]
},
{
"uniprot_ac": "Q8BGW6",
"gene_name": "Stk32a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BGW6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BGW6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BGW6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BGW6"
}
]
}
]
},
{
"uniprot_ac": "Q8BHI9",
"gene_name": "Nim1k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BHI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BHI9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BHI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BHI9"
}
]
}
]
},
{
"uniprot_ac": "Q8BI55",
"gene_name": "Dyrk4",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BI55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BI55"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q8BI55",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BI55"
}
]
}
]
},
{
"uniprot_ac": "Q8BK63",
"gene_name": "Csnk1a1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BK63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BK63"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BK63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BK63"
}
]
}
]
},
{
"uniprot_ac": "Q8BKX6",
"gene_name": "Smg1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BKX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BKX6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BKX6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BKX6"
}
]
}
]
},
{
"uniprot_ac": "Q8BLF2",
"gene_name": "Cdkl3",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BLF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BLF2"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8BLF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BLF2"
}
]
}
]
},
{
"uniprot_ac": "Q8BLK9",
"gene_name": "Rps6kc1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BLK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BLK9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BLK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BLK9"
}
]
}
]
},
{
"uniprot_ac": "Q8BN21",
"gene_name": "Vrk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BN21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BN21"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BN21",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BN21"
}
]
}
]
},
{
"uniprot_ac": "Q8BPM2",
"gene_name": "Map4k5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BPM2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BPM2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BPM2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BPM2"
}
]
}
]
},
{
"uniprot_ac": "Q8BRK8",
"gene_name": "Prkaa2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BRK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BRK8"
}
]
},
{
"ec_number": "2.7.11.31",
"activity": "ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O-phospho-L-seryl-[acetyl-CoA carboxylase].",
"evidence": [
{
"id": "Q8BRK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BRK8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BRK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BRK8"
}
]
}
]
},
{
"uniprot_ac": "Q8BSK8",
"gene_name": "Rps6kb1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BSK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BSK8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BSK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BSK8"
}
]
}
]
},
{
"uniprot_ac": "Q8BTH8",
"gene_name": "Csnk1g1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BTH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BTH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTH8"
}
]
}
]
},
{
"uniprot_ac": "Q8BTI9",
"gene_name": "Pik3cb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BTI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTI9"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q8BTI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTI9"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "Q8BTI9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTI9"
}
]
}
]
},
{
"uniprot_ac": "Q8BTW9",
"gene_name": "Pak4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BTW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTW9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BTW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BTW9"
}
]
}
]
},
{
"uniprot_ac": "Q8BVP5",
"gene_name": "Csnk1g2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BVP5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BVP5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BVP5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BVP5"
}
]
}
]
},
{
"uniprot_ac": "Q8BW96",
"gene_name": "Camk1d",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BW96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BW96"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q8BW96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BW96"
}
]
}
]
},
{
"uniprot_ac": "Q8BWD8",
"gene_name": "Cdk19",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BWD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWD8"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8BWD8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWD8"
}
]
}
]
},
{
"uniprot_ac": "Q8BWE1",
"gene_name": "1810024B03Rik",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BWE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWE1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BWE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWE1"
}
]
}
]
},
{
"uniprot_ac": "Q8BWQ5",
"gene_name": "Dclk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BWQ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWQ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BWQ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWQ5"
}
]
}
]
},
{
"uniprot_ac": "Q8BWW9",
"gene_name": "Pkn2",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BWW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWW9"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q8BWW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BWW9"
}
]
}
]
},
{
"uniprot_ac": "Q8BYC6",
"gene_name": "Taok3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BYC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BYC6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BYC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BYC6"
}
]
}
]
},
{
"uniprot_ac": "Q8BYR2",
"gene_name": "Lats1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BYR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BYR2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BYR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BYR2"
}
]
}
]
},
{
"uniprot_ac": "Q8BZ03",
"gene_name": "Prkd2",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BZ03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZ03"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q8BZ03",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZ03"
}
]
}
]
},
{
"uniprot_ac": "Q8BZ25",
"gene_name": "Ankk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BZ25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZ25"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BZ25",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZ25"
}
]
}
]
},
{
"uniprot_ac": "Q8BZN4",
"gene_name": "Nuak2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8BZN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZN4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8BZN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8BZN4"
}
]
}
]
},
{
"uniprot_ac": "Q8C015",
"gene_name": "Pak5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C015",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C015"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C015",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C015"
}
]
}
]
},
{
"uniprot_ac": "Q8C050",
"gene_name": "Rps6ka5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C050"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C050",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C050"
}
]
}
]
},
{
"uniprot_ac": "Q8C078",
"gene_name": "Camkk2",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C078",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C078"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q8C078",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C078"
}
]
}
]
},
{
"uniprot_ac": "Q8C0N0",
"gene_name": "Gm4922",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C0N0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0N0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C0N0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0N0"
}
]
}
]
},
{
"uniprot_ac": "Q8C0P0",
"gene_name": "Mastl",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C0P0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0P0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C0P0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0P0"
}
]
}
]
},
{
"uniprot_ac": "Q8C0Q4",
"gene_name": "Nek11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C0Q4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0Q4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C0Q4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0Q4"
}
]
}
]
},
{
"uniprot_ac": "Q8C0V0",
"gene_name": "Tlk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C0V0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0V0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C0V0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0V0"
}
]
}
]
},
{
"uniprot_ac": "Q8C0V7",
"gene_name": "Stk-ps2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C0V7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0V7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C0V7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0V7"
}
]
}
]
},
{
"uniprot_ac": "Q8C0X8",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C0X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0X8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C0X8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C0X8"
}
]
}
]
},
{
"uniprot_ac": "Q8C1R0",
"gene_name": "Tssk5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C1R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C1R0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C1R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C1R0"
}
]
}
]
},
{
"uniprot_ac": "Q8C4X2",
"gene_name": "Csnk1g3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8C4X2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C4X2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8C4X2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C4X2"
}
]
}
]
},
{
"uniprot_ac": "Q8CDB0",
"gene_name": "Mknk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CDB0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CDB0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8CDB0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CDB0"
}
]
}
]
},
{
"uniprot_ac": "Q8CE90",
"gene_name": "Map2k7",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CE90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CE90"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q8CE90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CE90"
}
]
}
]
},
{
"uniprot_ac": "Q8CEE6",
"gene_name": "Pask",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CEE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CEE6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8CEE6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CEE6"
}
]
}
]
},
{
"uniprot_ac": "Q8CEQ0",
"gene_name": "Cdkl1",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CEQ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CEQ0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8CEQ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CEQ0"
}
]
}
]
},
{
"uniprot_ac": "Q8CFH6",
"gene_name": "Sik2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CFH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CFH6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8CFH6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CFH6"
}
]
}
]
},
{
"uniprot_ac": "Q8CIN4",
"gene_name": "Pak2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CIN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIN4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8CIN4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIN4"
}
]
}
]
},
{
"uniprot_ac": "Q8CIP4",
"gene_name": "Mark4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CIP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIP4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8CIP4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIP4"
}
]
}
]
},
{
"uniprot_ac": "Q8CIR4",
"gene_name": "Trpm6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8CIR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIR4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8CIR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8CIR4"
}
]
}
]
},
{
"uniprot_ac": "Q8IMC6",
"gene_name": "Asator",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IMC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IMC6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IMC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IMC6"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "Q8IMC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IMC6"
}
]
}
]
},
{
"uniprot_ac": "Q8INB9",
"gene_name": "Akt",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8INB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8INB9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8INB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8INB9"
}
]
}
]
},
{
"uniprot_ac": "Q8IR79",
"gene_name": "LIMK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IR79",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IR79"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IR79",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IR79"
}
]
},
{
"ec_number": "2.7.11.-",
"activity": "",
"evidence": [
{
"id": "Q8IR79",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IR79"
}
]
}
]
},
{
"uniprot_ac": "Q8IU85",
"gene_name": "CAMK1D",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IU85",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IU85"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q8IU85",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IU85"
}
]
}
]
},
{
"uniprot_ac": "Q8IVH8",
"gene_name": "MAP4K3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IVH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IVH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVH8"
}
]
}
]
},
{
"uniprot_ac": "Q8IVT5",
"gene_name": "KSR1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IVT5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVT5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IVT5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVT5"
}
]
}
]
},
{
"uniprot_ac": "Q8IVW4",
"gene_name": "CDKL3",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IVW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVW4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8IVW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IVW4"
}
]
}
]
},
{
"uniprot_ac": "Q8IW41",
"gene_name": "MAPKAPK5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IW41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IW41"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IW41",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IW41"
}
]
}
]
},
{
"uniprot_ac": "Q8IWQ3",
"gene_name": "BRSK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IWQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWQ3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IWQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWQ3"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q8IWQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWQ3"
}
]
}
]
},
{
"uniprot_ac": "Q8IWU2",
"gene_name": "LMTK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IWU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWU2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IWU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IWU2"
}
]
}
]
},
{
"uniprot_ac": "Q8IXL6",
"gene_name": "FAM20C",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IXL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IXL6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IXL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IXL6"
}
]
}
]
},
{
"uniprot_ac": "Q8IY84",
"gene_name": "NIM1K",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IY84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IY84"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IY84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IY84"
}
]
}
]
},
{
"uniprot_ac": "Q8IYT8",
"gene_name": "ULK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IYT8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYT8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IYT8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IYT8"
}
]
}
]
},
{
"uniprot_ac": "Q8IZL9",
"gene_name": "CDK20",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IZL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IZL9"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8IZL9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IZL9"
}
]
}
]
},
{
"uniprot_ac": "Q8K045",
"gene_name": "Pkn3",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8K045",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K045"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q8K045",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K045"
}
]
}
]
},
{
"uniprot_ac": "Q8K0D0",
"gene_name": "Cdk17",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8K0D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K0D0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8K0D0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K0D0"
}
]
}
]
},
{
"uniprot_ac": "Q8K1R7",
"gene_name": "Nek9",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8K1R7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K1R7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8K1R7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K1R7"
}
]
}
]
},
{
"uniprot_ac": "Q8K1Y2",
"gene_name": "Prkd3",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8K1Y2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K1Y2"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q8K1Y2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K1Y2"
}
]
}
]
},
{
"uniprot_ac": "Q8K3H5",
"gene_name": "Myo3a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8K3H5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K3H5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8K3H5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8K3H5"
}
]
}
]
},
{
"uniprot_ac": "Q8MSQ4",
"gene_name": "Mekk1",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8MSQ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8MSQ4"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q8MSQ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8MSQ4"
}
]
}
]
},
{
"uniprot_ac": "Q8MVR1",
"gene_name": "gbpC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8MVR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8MVR1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8MVR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8MVR1"
}
]
}
]
},
{
"uniprot_ac": "Q8MYF1",
"gene_name": "",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8MYF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8MYF1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8MYF1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8MYF1"
}
]
}
]
},
{
"uniprot_ac": "Q8N165",
"gene_name": "PDIK1L",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8N165",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N165"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8N165",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N165"
}
]
}
]
},
{
"uniprot_ac": "Q8N2I9",
"gene_name": "STK40",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8N2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N2I9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8N2I9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N2I9"
}
]
}
]
},
{
"uniprot_ac": "Q8N4C8",
"gene_name": "MINK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8N4C8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N4C8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8N4C8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N4C8"
}
]
}
]
},
{
"uniprot_ac": "Q8N568",
"gene_name": "DCLK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8N568",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N568"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8N568",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N568"
}
]
}
]
},
{
"uniprot_ac": "Q8N5S9",
"gene_name": "CAMKK1",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8N5S9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N5S9"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q8N5S9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N5S9"
}
]
}
]
},
{
"uniprot_ac": "Q8N752",
"gene_name": "CSNK1A1L",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8N752",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N752"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8N752",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N752"
}
]
}
]
},
{
"uniprot_ac": "Q8NE63",
"gene_name": "HIPK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8NE63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NE63"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8NE63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NE63"
}
]
}
]
},
{
"uniprot_ac": "Q8NEV1",
"gene_name": "CSNK2A3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8NEV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEV1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8NEV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEV1"
}
]
}
]
},
{
"uniprot_ac": "Q8NEV4",
"gene_name": "MYO3A",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8NEV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEV4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8NEV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NEV4"
}
]
}
]
},
{
"uniprot_ac": "Q8NFD2",
"gene_name": "ANKK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8NFD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFD2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8NFD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NFD2"
}
]
}
]
},
{
"uniprot_ac": "Q8NG66",
"gene_name": "NEK11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8NG66",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG66"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8NG66",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NG66"
}
]
}
]
},
{
"uniprot_ac": "Q8QZR7",
"gene_name": "Pdik1l",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8QZR7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8QZR7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8QZR7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8QZR7"
}
]
}
]
},
{
"uniprot_ac": "Q8QZV4",
"gene_name": "Stk32c",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8QZV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8QZV4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8QZV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8QZV4"
}
]
}
]
},
{
"uniprot_ac": "Q8QZX0",
"gene_name": "Sbk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8QZX0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8QZX0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8QZX0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8QZX0"
}
]
}
]
},
{
"uniprot_ac": "Q8R2S1",
"gene_name": "Rps6kl1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8R2S1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R2S1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8R2S1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R2S1"
}
]
}
]
},
{
"uniprot_ac": "Q8R3L8",
"gene_name": "Cdk8",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8R3L8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R3L8"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q8R3L8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R3L8"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q8R3L8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R3L8"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q8R3L8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R3L8"
}
]
}
]
},
{
"uniprot_ac": "Q8R4K2",
"gene_name": "Irak4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8R4K2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4K2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8R4K2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4K2"
}
]
}
]
},
{
"uniprot_ac": "Q8R4U9",
"gene_name": "Sgk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8R4U9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4U9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8R4U9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4U9"
}
]
}
]
},
{
"uniprot_ac": "Q8R4V0",
"gene_name": "Sgk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8R4V0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4V0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8R4V0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8R4V0"
}
]
}
]
},
{
"uniprot_ac": "Q8SSS9",
"gene_name": "qkgA-2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8SSS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SSS9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8SSS9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SSS9"
}
]
}
]
},
{
"uniprot_ac": "Q8SSV3",
"gene_name": "mkcD",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8SSV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SSV3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8SSV3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SSV3"
}
]
}
]
},
{
"uniprot_ac": "Q8SSY6",
"gene_name": "",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q8SSY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SSY6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8SSY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8SSY6"
}
]
}
]
},
{
"uniprot_ac": "Q8T0S6",
"gene_name": "hpo",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8T0S6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T0S6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8T0S6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T0S6"
}
]
}
]
},
{
"uniprot_ac": "Q8T2I8",
"gene_name": "sepA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8T2I8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T2I8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8T2I8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T2I8"
}
]
}
]
},
{
"uniprot_ac": "Q8T9L5",
"gene_name": "Lkb1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8T9L5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9L5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8T9L5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8T9L5"
}
]
}
]
},
{
"uniprot_ac": "Q8TAS1",
"gene_name": "UHMK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TAS1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TAS1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8TAS1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TAS1"
}
]
}
]
},
{
"uniprot_ac": "Q8TD08",
"gene_name": "MAPK15",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TD08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TD08"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q8TD08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TD08"
}
]
}
]
},
{
"uniprot_ac": "Q8TD19",
"gene_name": "NEK9",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TD19",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TD19"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8TD19",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TD19"
}
]
}
]
},
{
"uniprot_ac": "Q8TDC3",
"gene_name": "BRSK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TDC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDC3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8TDC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDC3"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q8TDC3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDC3"
}
]
}
]
},
{
"uniprot_ac": "Q8TDR2",
"gene_name": "STK35",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TDR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDR2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8TDR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDR2"
}
]
}
]
},
{
"uniprot_ac": "Q8TDX7",
"gene_name": "NEK7",
"activity": [
{
"ec_number": "2.7.11.34",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TDX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDX7"
}
]
},
{
"ec_number": "2.7.11.34",
"activity": "",
"evidence": [
{
"id": "Q8TDX7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TDX7"
}
]
}
]
},
{
"uniprot_ac": "Q8TF76",
"gene_name": "HASPIN",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8TF76",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TF76"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8TF76",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8TF76"
}
]
}
]
},
{
"uniprot_ac": "Q8VBY2",
"gene_name": "Camkk1",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VBY2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VBY2"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q8VBY2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VBY2"
}
]
}
]
},
{
"uniprot_ac": "Q8VCT9",
"gene_name": "Tesk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VCT9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VCT9"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q8VCT9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VCT9"
}
]
}
]
},
{
"uniprot_ac": "Q8VD65",
"gene_name": "Pik3r4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VD65",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VD65"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8VD65",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VD65"
}
]
}
]
},
{
"uniprot_ac": "Q8VDF3",
"gene_name": "Dapk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VDF3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDF3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8VDF3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDF3"
}
]
}
]
},
{
"uniprot_ac": "Q8VDG6",
"gene_name": "Map3k21",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VDG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDG6"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q8VDG6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDG6"
}
]
}
]
},
{
"uniprot_ac": "Q8VDU5",
"gene_name": "Snrk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VDU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDU5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8VDU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VDU5"
}
]
}
]
},
{
"uniprot_ac": "Q8VHF0",
"gene_name": "Mark3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VHF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHF0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8VHF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHF0"
}
]
}
]
},
{
"uniprot_ac": "Q8VHJ5",
"gene_name": "Mark1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8VHJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHJ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8VHJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHJ5"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q8VHJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHJ5"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q8VHJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8VHJ5"
}
]
}
]
},
{
"uniprot_ac": "Q8WU08",
"gene_name": "STK32A",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8WU08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WU08"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8WU08",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WU08"
}
]
}
]
},
{
"uniprot_ac": "Q8WXR4",
"gene_name": "MYO3B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8WXR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WXR4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8WXR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WXR4"
}
]
}
]
},
{
"uniprot_ac": "Q8WZ42",
"gene_name": "TTN",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8WZ42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WZ42"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8WZ42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8WZ42"
}
]
}
]
},
{
"uniprot_ac": "Q91VB2",
"gene_name": "Camk1g",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91VB2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VB2"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q91VB2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VB2"
}
]
}
]
},
{
"uniprot_ac": "Q91VJ4",
"gene_name": "Stk38",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91VJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VJ4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91VJ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91VJ4"
}
]
}
]
},
{
"uniprot_ac": "Q91XS8",
"gene_name": "Stk17b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91XS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XS8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91XS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91XS8"
}
]
}
]
},
{
"uniprot_ac": "Q91Y86",
"gene_name": "Mapk8",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91Y86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91Y86"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q91Y86",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91Y86"
}
]
}
]
},
{
"uniprot_ac": "Q91YA2",
"gene_name": "Pskh1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91YA2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91YA2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91YA2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91YA2"
}
]
}
]
},
{
"uniprot_ac": "Q91YS8",
"gene_name": "Camk1",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91YS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91YS8"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q91YS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91YS8"
}
]
}
]
},
{
"uniprot_ac": "Q91Z96",
"gene_name": "Bmp2k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91Z96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91Z96"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91Z96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91Z96"
}
]
}
]
},
{
"uniprot_ac": "Q91ZB0",
"gene_name": "Alpk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91ZB0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZB0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91ZB0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZB0"
}
]
}
]
},
{
"uniprot_ac": "Q91ZN7",
"gene_name": "Chek1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91ZN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZN7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91ZN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZN7"
}
]
},
{
"ec_number": "2.4.99.18",
"activity": "a dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = a dolichyl diphosphate + H(+) + N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginy-[protein].",
"evidence": [
{
"id": "Q91ZN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZN7"
}
]
},
{
"ec_number": "2.4.99.18",
"activity": "",
"evidence": [
{
"id": "Q91ZN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZN7"
}
]
}
]
},
{
"uniprot_ac": "Q91ZR4",
"gene_name": "Nek8",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q91ZR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZR4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q91ZR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91ZR4"
}
]
}
]
},
{
"uniprot_ac": "Q922Q2",
"gene_name": "Riok1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q922Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922Q2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q922Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922Q2"
}
]
},
{
"ec_number": "3.6.3.-",
"activity": "",
"evidence": [
{
"id": "Q922Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922Q2"
}
]
}
]
},
{
"uniprot_ac": "Q922R0",
"gene_name": "Prkx",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q922R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922R0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q922R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922R0"
}
]
}
]
},
{
"uniprot_ac": "Q922Y0",
"gene_name": "Dyrk3",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q922Y0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922Y0"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q922Y0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q922Y0"
}
]
}
]
},
{
"uniprot_ac": "Q923J1",
"gene_name": "Trpm7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q923J1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q923J1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q923J1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q923J1"
}
]
}
]
},
{
"uniprot_ac": "Q923T9",
"gene_name": "Camk2g",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q923T9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q923T9"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q923T9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q923T9"
}
]
}
]
},
{
"uniprot_ac": "Q924C5",
"gene_name": "Alpk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q924C5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924C5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q924C5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924C5"
}
]
}
]
},
{
"uniprot_ac": "Q924I2",
"gene_name": "Map4k3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q924I2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924I2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q924I2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924I2"
}
]
}
]
},
{
"uniprot_ac": "Q924U5",
"gene_name": "Tesk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q924U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924U5"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q924U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924U5"
}
]
}
]
},
{
"uniprot_ac": "Q924X7",
"gene_name": "Stk33",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q924X7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924X7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q924X7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q924X7"
}
]
}
]
},
{
"uniprot_ac": "Q925B3",
"gene_name": "Trpm7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q925B3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q925B3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q925B3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q925B3"
}
]
}
]
},
{
"uniprot_ac": "Q925D6",
"gene_name": "Map2k6",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q925D6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q925D6"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q925D6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q925D6"
}
]
}
]
},
{
"uniprot_ac": "Q925K9",
"gene_name": "Tssk6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q925K9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q925K9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q925K9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q925K9"
}
]
}
]
},
{
"uniprot_ac": "Q92630",
"gene_name": "DYRK2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q92630",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92630"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q92630",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92630"
}
]
}
]
},
{
"uniprot_ac": "Q92772",
"gene_name": "CDKL2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q92772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92772"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q92772",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92772"
}
]
}
]
},
{
"uniprot_ac": "Q92918",
"gene_name": "MAP4K1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q92918",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92918"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q92918",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92918"
}
]
}
]
},
{
"uniprot_ac": "Q94533",
"gene_name": "S6k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q94533",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q94533"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q94533",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q94533"
}
]
}
]
},
{
"uniprot_ac": "Q95SH0",
"gene_name": "Pask",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q95SH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95SH0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q95SH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95SH0"
}
]
}
]
},
{
"uniprot_ac": "Q95TN8",
"gene_name": "gwl",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q95TN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95TN8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q95TN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95TN8"
}
]
}
]
},
{
"uniprot_ac": "Q95UN8",
"gene_name": "slpr",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q95UN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95UN8"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q95UN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95UN8"
}
]
}
]
},
{
"uniprot_ac": "Q95YH0",
"gene_name": "cdk8",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q95YH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95YH0"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q95YH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95YH0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q95YH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95YH0"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q95YH0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q95YH0"
}
]
}
]
},
{
"uniprot_ac": "Q96BR1",
"gene_name": "SGK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96BR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BR1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96BR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96BR1"
}
]
}
]
},
{
"uniprot_ac": "Q96C45",
"gene_name": "ULK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96C45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96C45"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96C45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96C45"
}
]
}
]
},
{
"uniprot_ac": "Q96GD4",
"gene_name": "AURKB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96GD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GD4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96GD4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GD4"
}
]
}
]
},
{
"uniprot_ac": "Q96GX5",
"gene_name": "MASTL",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96GX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GX5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96GX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96GX5"
}
]
}
]
},
{
"uniprot_ac": "Q96J92",
"gene_name": "WNK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96J92",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96J92"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96J92",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96J92"
}
]
}
]
},
{
"uniprot_ac": "Q96KB5",
"gene_name": "PBK",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96KB5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96KB5"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q96KB5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96KB5"
}
]
}
]
},
{
"uniprot_ac": "Q96L34",
"gene_name": "MARK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96L34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96L34"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96L34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96L34"
}
]
}
]
},
{
"uniprot_ac": "Q96L96",
"gene_name": "ALPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96L96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96L96"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96L96",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96L96"
}
]
}
]
},
{
"uniprot_ac": "Q96LW2",
"gene_name": "RSKR",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96LW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96LW2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96LW2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96LW2"
}
]
}
]
},
{
"uniprot_ac": "Q96NX5",
"gene_name": "CAMK1G",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96NX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96NX5"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q96NX5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96NX5"
}
]
}
]
},
{
"uniprot_ac": "Q96PF2",
"gene_name": "TSSK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96PF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PF2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96PF2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PF2"
}
]
}
]
},
{
"uniprot_ac": "Q96PN8",
"gene_name": "TSSK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96PN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PN8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96PN8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PN8"
}
]
}
]
},
{
"uniprot_ac": "Q96PU5",
"gene_name": "NEDD4L",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.36",
"activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
},
{
"ec_number": "2.3.2.36",
"activity": "",
"evidence": [
{
"id": "Q96PU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PU5"
}
]
}
]
},
{
"uniprot_ac": "Q96PY6",
"gene_name": "NEK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96PY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PY6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96PY6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96PY6"
}
]
}
]
},
{
"uniprot_ac": "Q96Q04",
"gene_name": "LMTK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96Q04",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96Q04"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96Q04",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96Q04"
}
]
}
]
},
{
"uniprot_ac": "Q96Q15",
"gene_name": "SMG1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96Q15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96Q15"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96Q15",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96Q15"
}
]
}
]
},
{
"uniprot_ac": "Q96Q40",
"gene_name": "CDK15",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96Q40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96Q40"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q96Q40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96Q40"
}
]
}
]
},
{
"uniprot_ac": "Q96QP1",
"gene_name": "ALPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96QP1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96QP1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96QP1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96QP1"
}
]
}
]
},
{
"uniprot_ac": "Q96QS6",
"gene_name": "PSKH2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96QS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96QS6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96QS6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96QS6"
}
]
}
]
},
{
"uniprot_ac": "Q96QT4",
"gene_name": "TRPM7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96QT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96QT4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96QT4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96QT4"
}
]
}
]
},
{
"uniprot_ac": "Q96RG2",
"gene_name": "PASK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96RG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96RG2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96RG2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96RG2"
}
]
}
]
},
{
"uniprot_ac": "Q96RR4",
"gene_name": "CAMKK2",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96RR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96RR4"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q96RR4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96RR4"
}
]
}
]
},
{
"uniprot_ac": "Q96S38",
"gene_name": "RPS6KC1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96S38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S38"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96S38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S38"
}
]
}
]
},
{
"uniprot_ac": "Q96S44",
"gene_name": "TP53RK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96S44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S44"
}
]
},
{
"ec_number": "3.6.-.-",
"activity": "",
"evidence": [
{
"id": "Q96S44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S44"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96S44",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S44"
}
]
}
]
},
{
"uniprot_ac": "Q96S53",
"gene_name": "TESK2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96S53",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S53"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q96S53",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96S53"
}
]
}
]
},
{
"uniprot_ac": "Q96SB4",
"gene_name": "SRPK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q96SB4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SB4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q96SB4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96SB4"
}
]
}
]
},
{
"uniprot_ac": "Q99558",
"gene_name": "MAP3K14",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99558",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99558"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q99558",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99558"
}
]
}
]
},
{
"uniprot_ac": "Q99570",
"gene_name": "PIK3R4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99570"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99570"
}
]
}
]
},
{
"uniprot_ac": "Q99640",
"gene_name": "PKMYT1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99640",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99640"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99640",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99640"
}
]
}
]
},
{
"uniprot_ac": "Q99683",
"gene_name": "MAP3K5",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99683"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q99683",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99683"
}
]
}
]
},
{
"uniprot_ac": "Q99759",
"gene_name": "MAP3K3",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99759"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q99759",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99759"
}
]
}
]
},
{
"uniprot_ac": "Q99986",
"gene_name": "VRK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99986",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99986"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99986",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99986"
}
]
}
]
},
{
"uniprot_ac": "Q99J82",
"gene_name": "Ilk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99J82",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J82"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99J82",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J82"
}
]
}
]
},
{
"uniprot_ac": "Q99J95",
"gene_name": "Cdk9",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99J95",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J95"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q99J95",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J95"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q99J95",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J95"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q99J95",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99J95"
}
]
}
]
},
{
"uniprot_ac": "Q99JP0",
"gene_name": "Map4k3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99JP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99JP0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99JP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99JP0"
}
]
}
]
},
{
"uniprot_ac": "Q99JT2",
"gene_name": "Stk26",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99JT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99JT2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99JT2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99JT2"
}
]
}
]
},
{
"uniprot_ac": "Q99KH8",
"gene_name": "Stk24",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99KH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99KH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99KH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99KH8"
}
]
}
]
},
{
"uniprot_ac": "Q99KY4",
"gene_name": "Gak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99KY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99KY4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99KY4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99KY4"
}
]
}
]
},
{
"uniprot_ac": "Q99MQ3",
"gene_name": "Pink1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99MQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MQ3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99MQ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MQ3"
}
]
}
]
},
{
"uniprot_ac": "Q99MW1",
"gene_name": "Stk31",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99MW1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MW1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99MW1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99MW1"
}
]
}
]
},
{
"uniprot_ac": "Q99N57",
"gene_name": "Raf1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99N57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99N57"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99N57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99N57"
}
]
}
]
},
{
"uniprot_ac": "Q99PW4",
"gene_name": "Tp53rkb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q99PW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PW4"
}
]
},
{
"ec_number": "3.6.-.-",
"activity": "",
"evidence": [
{
"id": "Q99PW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PW4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q99PW4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q99PW4"
}
]
}
]
},
{
"uniprot_ac": "Q9BQI3",
"gene_name": "EIF2AK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BQI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BQI3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BQI3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BQI3"
}
]
}
]
},
{
"uniprot_ac": "Q9BRS2",
"gene_name": "RIOK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BRS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BRS2"
}
]
},
{
"ec_number": "3.6.3.-",
"activity": "",
"evidence": [
{
"id": "Q9BRS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BRS2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BRS2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BRS2"
}
]
}
]
},
{
"uniprot_ac": "Q9BUB5",
"gene_name": "MKNK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BUB5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BUB5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BUB5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BUB5"
}
]
}
]
},
{
"uniprot_ac": "Q9BVS4",
"gene_name": "RIOK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BVS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BVS4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BVS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BVS4"
}
]
}
]
},
{
"uniprot_ac": "Q9BWU1",
"gene_name": "CDK19",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BWU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BWU1"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9BWU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BWU1"
}
]
}
]
},
{
"uniprot_ac": "Q9BX84",
"gene_name": "TRPM6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BX84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BX84"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BX84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BX84"
}
]
}
]
},
{
"uniprot_ac": "Q9BXA6",
"gene_name": "TSSK6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BXA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXA6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BXA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXA6"
}
]
}
]
},
{
"uniprot_ac": "Q9BXA7",
"gene_name": "TSSK1B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BXA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXA7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BXA7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXA7"
}
]
}
]
},
{
"uniprot_ac": "Q9BXM7",
"gene_name": "PINK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BXM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXM7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BXM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXM7"
}
]
}
]
},
{
"uniprot_ac": "Q9BXU1",
"gene_name": "STK31",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BXU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXU1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BXU1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BXU1"
}
]
}
]
},
{
"uniprot_ac": "Q9BYP7",
"gene_name": "WNK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BYP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYP7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BYP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYP7"
}
]
}
]
},
{
"uniprot_ac": "Q9BYT3",
"gene_name": "STK33",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BYT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYT3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9BYT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BYT3"
}
]
}
]
},
{
"uniprot_ac": "Q9BZL6",
"gene_name": "PRKD2",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9BZL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BZL6"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q9BZL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BZL6"
}
]
}
]
},
{
"uniprot_ac": "Q9C098",
"gene_name": "DCLK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9C098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C098"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9C098",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9C098"
}
]
}
]
},
{
"uniprot_ac": "Q9CQS5",
"gene_name": "Riok2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9CQS5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CQS5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9CQS5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CQS5"
}
]
}
]
},
{
"uniprot_ac": "Q9CXB8",
"gene_name": "Alpk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9CXB8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CXB8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9CXB8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9CXB8"
}
]
}
]
},
{
"uniprot_ac": "Q9D2E1",
"gene_name": "Tssk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9D2E1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D2E1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9D2E1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D2E1"
}
]
}
]
},
{
"uniprot_ac": "Q9D411",
"gene_name": "Tssk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9D411",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D411"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9D411",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9D411"
}
]
}
]
},
{
"uniprot_ac": "Q9DBU3",
"gene_name": "Riok3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9DBU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBU3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9DBU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DBU3"
}
]
}
]
},
{
"uniprot_ac": "Q9DC28",
"gene_name": "Csnk1d",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9DC28",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DC28"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q9DC28",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DC28"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9DC28",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DC28"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q9DC28",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9DC28"
}
]
}
]
},
{
"uniprot_ac": "Q9EQY0",
"gene_name": "Ern1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9EQY0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQY0"
}
]
},
{
"ec_number": "3.1.26.-",
"activity": "",
"evidence": [
{
"id": "Q9EQY0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9EQY0"
}
]
}
]
},
{
"uniprot_ac": "Q9ERE3",
"gene_name": "Sgk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ERE3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ERE3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9ERE3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ERE3"
}
]
}
]
},
{
"uniprot_ac": "Q9ERH7",
"gene_name": "Hipk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ERH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ERH7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9ERH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ERH7"
}
]
}
]
},
{
"uniprot_ac": "Q9ERK0",
"gene_name": "Ripk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ERK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ERK0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9ERK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ERK0"
}
]
}
]
},
{
"uniprot_ac": "Q9ES70",
"gene_name": "Nek6",
"activity": [
{
"ec_number": "2.7.11.34",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ES70",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES70"
}
]
},
{
"ec_number": "2.7.11.34",
"activity": "",
"evidence": [
{
"id": "Q9ES70",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES70"
}
]
}
]
},
{
"uniprot_ac": "Q9ES74",
"gene_name": "Nek7",
"activity": [
{
"ec_number": "2.7.11.34",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ES74",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES74"
}
]
},
{
"ec_number": "2.7.11.34",
"activity": "",
"evidence": [
{
"id": "Q9ES74",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES74"
}
]
}
]
},
{
"uniprot_ac": "Q9ESG9",
"gene_name": "Pkmyt1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ESG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ESG9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9ESG9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ESG9"
}
]
}
]
},
{
"uniprot_ac": "Q9ESL4",
"gene_name": "Map3k20",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9ESL4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ESL4"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9ESL4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ESL4"
}
]
}
]
},
{
"uniprot_ac": "Q9H093",
"gene_name": "NUAK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H093",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H093"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H093",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H093"
}
]
}
]
},
{
"uniprot_ac": "Q9H0K1",
"gene_name": "SIK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H0K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0K1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H0K1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0K1"
}
]
}
]
},
{
"uniprot_ac": "Q9H0M0",
"gene_name": "WWP1",
"activity": [
{
"ec_number": "2.3.2.26",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "Q9H0M0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0M0"
}
]
},
{
"ec_number": "2.3.2.26",
"activity": "",
"evidence": [
{
"id": "Q9H0M0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H0M0"
}
]
}
]
},
{
"uniprot_ac": "Q9H2G2",
"gene_name": "SLK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H2G2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2G2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H2G2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2G2"
}
]
}
]
},
{
"uniprot_ac": "Q9H2K8",
"gene_name": "TAOK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H2K8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2K8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H2K8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2K8"
}
]
}
]
},
{
"uniprot_ac": "Q9H2X6",
"gene_name": "HIPK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H2X6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2X6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H2X6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H2X6"
}
]
}
]
},
{
"uniprot_ac": "Q9H422",
"gene_name": "HIPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H422",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H422"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H422",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H422"
}
]
}
]
},
{
"uniprot_ac": "Q9H4A3",
"gene_name": "WNK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H4A3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4A3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9H4A3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4A3"
}
]
}
]
},
{
"uniprot_ac": "Q9H4B4",
"gene_name": "PLK3",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9H4B4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4B4"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q9H4B4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9H4B4"
}
]
}
]
},
{
"uniprot_ac": "Q9HAZ1",
"gene_name": "CLK4",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9HAZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HAZ1"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q9HAZ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HAZ1"
}
]
}
]
},
{
"uniprot_ac": "Q9HBH9",
"gene_name": "MKNK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9HBH9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBH9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9HBH9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBH9"
}
]
}
]
},
{
"uniprot_ac": "Q9HBY8",
"gene_name": "SGK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9HBY8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBY8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9HBY8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HBY8"
}
]
}
]
},
{
"uniprot_ac": "Q9HC98",
"gene_name": "NEK6",
"activity": [
{
"ec_number": "2.7.11.34",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9HC98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HC98"
}
]
},
{
"ec_number": "2.7.11.34",
"activity": "",
"evidence": [
{
"id": "Q9HC98",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HC98"
}
]
}
]
},
{
"uniprot_ac": "Q9HCP0",
"gene_name": "CSNK1G1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9HCP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCP0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9HCP0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9HCP0"
}
]
}
]
},
{
"uniprot_ac": "Q9JHG7",
"gene_name": "Pik3cg",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "Q9JHG7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHG7"
}
]
}
]
},
{
"uniprot_ac": "Q9JHU3",
"gene_name": "Cdk20",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JHU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHU3"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9JHU3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JHU3"
}
]
}
]
},
{
"uniprot_ac": "Q9JI10",
"gene_name": "Stk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JI10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JI10"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JI10",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JI10"
}
]
}
]
},
{
"uniprot_ac": "Q9JI11",
"gene_name": "Stk4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JI11",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JI11"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JI11",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JI11"
}
]
}
]
},
{
"uniprot_ac": "Q9JIH7",
"gene_name": "Wnk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JIH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIH7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JIH7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIH7"
}
]
}
]
},
{
"uniprot_ac": "Q9JIX9",
"gene_name": "Fastk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JIX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIX9"
}
]
},
{
"ec_number": "2.7.11.8",
"activity": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein].",
"evidence": [
{
"id": "Q9JIX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIX9"
}
]
},
{
"ec_number": "2.7.11.8",
"activity": "",
"evidence": [
{
"id": "Q9JIX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIX9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JIX9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JIX9"
}
]
}
]
},
{
"uniprot_ac": "Q9JJ78",
"gene_name": "Pbk",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JJ78",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJ78"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q9JJ78",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJ78"
}
]
}
]
},
{
"uniprot_ac": "Q9JJX8",
"gene_name": "Stk32b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JJX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJX8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JJX8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JJX8"
}
]
}
]
},
{
"uniprot_ac": "Q9JKK8",
"gene_name": "Atr",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JKK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JKK8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JKK8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JKK8"
}
]
}
]
},
{
"uniprot_ac": "Q9JKV2",
"gene_name": "Cilk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JKV2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JKV2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JKV2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JKV2"
}
]
}
]
},
{
"uniprot_ac": "Q9JLM8",
"gene_name": "Dclk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JLM8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JLM8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JLM8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JLM8"
}
]
}
]
},
{
"uniprot_ac": "Q9JLN9",
"gene_name": "Mtor",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JLN9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JLN9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JLN9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JLN9"
}
]
}
]
},
{
"uniprot_ac": "Q9JLS3",
"gene_name": "Taok2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JLS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JLS3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JLS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JLS3"
}
]
}
]
},
{
"uniprot_ac": "Q9JM01",
"gene_name": "Cdkl3",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JM01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JM01"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9JM01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JM01"
}
]
}
]
},
{
"uniprot_ac": "Q9JM52",
"gene_name": "Mink1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JM52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JM52"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JM52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JM52"
}
]
}
]
},
{
"uniprot_ac": "Q9JMK2",
"gene_name": "Csnk1e",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9JMK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JMK2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9JMK2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JMK2"
}
]
}
]
},
{
"uniprot_ac": "Q9NBK5",
"gene_name": "trc",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NBK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NBK5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NBK5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NBK5"
}
]
}
]
},
{
"uniprot_ac": "Q9NGW9",
"gene_name": "mkcB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NGW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NGW9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NGW9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NGW9"
}
]
}
]
},
{
"uniprot_ac": "Q9NI63",
"gene_name": "Myt1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NI63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NI63"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NI63",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NI63"
}
]
}
]
},
{
"uniprot_ac": "Q9NIV1",
"gene_name": "PEK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NIV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NIV1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NIV1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NIV1"
}
]
}
]
},
{
"uniprot_ac": "Q9NQU5",
"gene_name": "PAK6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NQU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQU5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NQU5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NQU5"
}
]
}
]
},
{
"uniprot_ac": "Q9NR20",
"gene_name": "DYRK4",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NR20",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NR20"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q9NR20",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NR20"
}
]
}
]
},
{
"uniprot_ac": "Q9NRH2",
"gene_name": "SNRK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NRH2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRH2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NRH2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRH2"
}
]
}
]
},
{
"uniprot_ac": "Q9NRM7",
"gene_name": "LATS2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NRM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRM7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NRM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRM7"
}
]
}
]
},
{
"uniprot_ac": "Q9NRP7",
"gene_name": "STK36",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NRP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRP7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NRP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRP7"
}
]
}
]
},
{
"uniprot_ac": "Q9NSY1",
"gene_name": "BMP2K",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NSY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NSY1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NSY1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NSY1"
}
]
}
]
},
{
"uniprot_ac": "Q9NWZ3",
"gene_name": "IRAK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NWZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NWZ3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NWZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NWZ3"
}
]
}
]
},
{
"uniprot_ac": "Q9NY57",
"gene_name": "STK32B",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NY57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NY57"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NY57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NY57"
}
]
}
]
},
{
"uniprot_ac": "Q9NYL2",
"gene_name": "MAP3K20",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NYL2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYL2"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9NYL2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYL2"
}
]
}
]
},
{
"uniprot_ac": "Q9NYV4",
"gene_name": "CDK12",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NYV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYV4"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q9NYV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYV4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9NYV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYV4"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q9NYV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYV4"
}
]
}
]
},
{
"uniprot_ac": "Q9NYY3",
"gene_name": "PLK2",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NYY3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYY3"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q9NYY3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NYY3"
}
]
}
]
},
{
"uniprot_ac": "Q9NZJ5",
"gene_name": "EIF2AK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9NZJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NZJ5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9NZJ5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NZJ5"
}
]
}
]
},
{
"uniprot_ac": "Q9P0L2",
"gene_name": "MARK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9P0L2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P0L2"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q9P0L2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P0L2"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q9P0L2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P0L2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9P0L2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P0L2"
}
]
}
]
},
{
"uniprot_ac": "Q9P1W9",
"gene_name": "PIM2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9P1W9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P1W9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9P1W9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P1W9"
}
]
}
]
},
{
"uniprot_ac": "Q9P286",
"gene_name": "PAK5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9P286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P286"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9P286",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P286"
}
]
}
]
},
{
"uniprot_ac": "Q9P289",
"gene_name": "STK26",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9P289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P289"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9P289",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P289"
}
]
}
]
},
{
"uniprot_ac": "Q9P2K8",
"gene_name": "EIF2AK4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9P2K8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P2K8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9P2K8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9P2K8"
}
]
}
]
},
{
"uniprot_ac": "Q9QUK0",
"gene_name": "Cdkl2",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QUK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QUK0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9QUK0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QUK0"
}
]
}
]
},
{
"uniprot_ac": "Q9QY01",
"gene_name": "Ulk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QY01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY01"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QY01",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY01"
}
]
}
]
},
{
"uniprot_ac": "Q9QY78",
"gene_name": "Ikbkb",
"activity": [
{
"ec_number": "2.7.11.10",
"activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].",
"evidence": [
{
"id": "Q9QY78",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY78"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QY78",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY78"
}
]
},
{
"ec_number": "2.7.11.10",
"activity": "",
"evidence": [
{
"id": "Q9QY78",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QY78"
}
]
}
]
},
{
"uniprot_ac": "Q9QYK9",
"gene_name": "Pnck",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QYK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYK9"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q9QYK9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYK9"
}
]
}
]
},
{
"uniprot_ac": "Q9QYZ3",
"gene_name": "Smok2b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QYZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYZ3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QYZ3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYZ3"
}
]
}
]
},
{
"uniprot_ac": "Q9QYZ4",
"gene_name": "Smok1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QYZ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYZ4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QYZ4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYZ4"
}
]
}
]
},
{
"uniprot_ac": "Q9QYZ6",
"gene_name": "Smok2a",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QYZ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYZ6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QYZ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QYZ6"
}
]
}
]
},
{
"uniprot_ac": "Q9QZ05",
"gene_name": "Eif2ak4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QZ05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZ05"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QZ05",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZ05"
}
]
}
]
},
{
"uniprot_ac": "Q9QZL0",
"gene_name": "Ripk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QZL0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZL0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QZL0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZL0"
}
]
}
]
},
{
"uniprot_ac": "Q9QZR5",
"gene_name": "Hipk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QZR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZR5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QZR5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZR5"
}
]
}
]
},
{
"uniprot_ac": "Q9QZS5",
"gene_name": "Sgk2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9QZS5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZS5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9QZS5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9QZS5"
}
]
}
]
},
{
"uniprot_ac": "Q9R011",
"gene_name": "Plk3",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9R011",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R011"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q9R011",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R011"
}
]
}
]
},
{
"uniprot_ac": "Q9R012",
"gene_name": "Plk2",
"activity": [
{
"ec_number": "2.7.11.21",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9R012",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R012"
}
]
},
{
"ec_number": "2.7.11.21",
"activity": "",
"evidence": [
{
"id": "Q9R012",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R012"
}
]
}
]
},
{
"uniprot_ac": "Q9R0A5",
"gene_name": "Nek3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9R0A5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R0A5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9R0A5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R0A5"
}
]
}
]
},
{
"uniprot_ac": "Q9R0G8",
"gene_name": "Nrk",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9R0G8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R0G8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9R0G8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R0G8"
}
]
}
]
},
{
"uniprot_ac": "Q9R1L5",
"gene_name": "Mast1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9R1L5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R1L5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9R1L5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R1L5"
}
]
}
]
},
{
"uniprot_ac": "Q9R1U5",
"gene_name": "Sik1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9R1U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R1U5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9R1U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9R1U5"
}
]
}
]
},
{
"uniprot_ac": "Q9UBE8",
"gene_name": "NLK",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UBE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBE8"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9UBE8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBE8"
}
]
}
]
},
{
"uniprot_ac": "Q9UBS0",
"gene_name": "RPS6KB2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UBS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBS0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UBS0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UBS0"
}
]
}
]
},
{
"uniprot_ac": "Q9UEE5",
"gene_name": "STK17A",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UEE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UEE5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UEE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UEE5"
}
]
}
]
},
{
"uniprot_ac": "Q9UEW8",
"gene_name": "STK39",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UEW8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UEW8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UEW8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UEW8"
}
]
}
]
},
{
"uniprot_ac": "Q9UHD2",
"gene_name": "TBK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UHD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHD2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UHD2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UHD2"
}
]
}
]
},
{
"uniprot_ac": "Q9UIK4",
"gene_name": "DAPK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UIK4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UIK4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UIK4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UIK4"
}
]
}
]
},
{
"uniprot_ac": "Q9UK32",
"gene_name": "RPS6KA6",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UK32",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UK32"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UK32",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UK32"
}
]
}
]
},
{
"uniprot_ac": "Q9UKE5",
"gene_name": "TNIK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UKE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UKE5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UKE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UKE5"
}
]
}
]
},
{
"uniprot_ac": "Q9UKI8",
"gene_name": "TLK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UKI8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UKI8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UKI8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UKI8"
}
]
}
]
},
{
"uniprot_ac": "Q9UL54",
"gene_name": "TAOK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UL54",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UL54"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UL54",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UL54"
}
]
}
]
},
{
"uniprot_ac": "Q9UPE1",
"gene_name": "SRPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UPE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UPE1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UPE1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UPE1"
}
]
}
]
},
{
"uniprot_ac": "Q9UPZ9",
"gene_name": "CILK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UPZ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UPZ9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UPZ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UPZ9"
}
]
}
]
},
{
"uniprot_ac": "Q9UQ07",
"gene_name": "MOK",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UQ07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQ07"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9UQ07",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQ07"
}
]
}
]
},
{
"uniprot_ac": "Q9UQ88",
"gene_name": "CDK11A",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UQ88",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQ88"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9UQ88",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQ88"
}
]
}
]
},
{
"uniprot_ac": "Q9UQB9",
"gene_name": "AURKC",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UQB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQB9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9UQB9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQB9"
}
]
}
]
},
{
"uniprot_ac": "Q9UQM7",
"gene_name": "CAMK2A",
"activity": [
{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9UQM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQM7"
}
]
},
{
"ec_number": "2.7.11.17",
"activity": "",
"evidence": [
{
"id": "Q9UQM7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9UQM7"
}
]
}
]
},
{
"uniprot_ac": "Q9V3D5",
"gene_name": "Dyrk2",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9V3D5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3D5"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q9V3D5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3D5"
}
]
}
]
},
{
"uniprot_ac": "Q9V3I5",
"gene_name": "JIL-1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9V3I5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3I5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9V3I5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3I5"
}
]
}
]
},
{
"uniprot_ac": "Q9V3Q6",
"gene_name": "Tak1",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9V3Q6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3Q6"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9V3Q6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9V3Q6"
}
]
}
]
},
{
"uniprot_ac": "Q9VA38",
"gene_name": "wts",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VA38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VA38"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VA38",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VA38"
}
]
}
]
},
{
"uniprot_ac": "Q9VBU2",
"gene_name": "RIOK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VBU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VBU2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VBU2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VBU2"
}
]
}
]
},
{
"uniprot_ac": "Q9VCV0",
"gene_name": "Takl2",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VCV0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VCV0"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9VCV0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VCV0"
}
]
}
]
},
{
"uniprot_ac": "Q9VD82",
"gene_name": "Dmel\\CG6800",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VD82",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VD82"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9VD82",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VD82"
}
]
}
]
},
{
"uniprot_ac": "Q9VE06",
"gene_name": "cdi",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VE06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VE06"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q9VE06",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VE06"
}
]
}
]
},
{
"uniprot_ac": "Q9VEN3",
"gene_name": "GckIII",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VEN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VEN3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VEN3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VEN3"
}
]
}
]
},
{
"uniprot_ac": "Q9VGF9",
"gene_name": "aurA",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VGF9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VGF9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VGF9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VGF9"
}
]
}
]
},
{
"uniprot_ac": "Q9VI13",
"gene_name": "Pak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VI13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VI13"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VI13",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VI13"
}
]
}
]
},
{
"uniprot_ac": "Q9VI84",
"gene_name": "Dmel\\CG1227",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VI84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VI84"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VI84",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VI84"
}
]
}
]
},
{
"uniprot_ac": "Q9VJ30",
"gene_name": "Nak",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VJ30",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VJ30"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VJ30",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VJ30"
}
]
}
]
},
{
"uniprot_ac": "Q9VJC2",
"gene_name": "Dmel\\CG7094",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VJC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VJC2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VJC2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VJC2"
}
]
}
]
},
{
"uniprot_ac": "Q9VK45",
"gene_name": "mTor",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VK45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VK45"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VK45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VK45"
}
]
}
]
},
{
"uniprot_ac": "Q9VKN7",
"gene_name": "aurB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VKN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VKN7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VKN7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VKN7"
}
]
}
]
},
{
"uniprot_ac": "Q9VL34",
"gene_name": "Dmel\\CG4839",
"activity": [
{
"ec_number": "2.7.11.12",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VL34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL34"
}
]
},
{
"ec_number": "2.7.11.12",
"activity": "",
"evidence": [
{
"id": "Q9VL34",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VL34"
}
]
}
]
},
{
"uniprot_ac": "Q9VM90",
"gene_name": "meng",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VM90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VM90"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VM90",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VM90"
}
]
}
]
},
{
"uniprot_ac": "Q9VMY8",
"gene_name": "aux",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VMY8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VMY8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VMY8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VMY8"
}
]
}
]
},
{
"uniprot_ac": "Q9VN23",
"gene_name": "CG10532",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VN23",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VN23"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VN23",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VN23"
}
]
}
]
},
{
"uniprot_ac": "Q9VP22",
"gene_name": "Cdk12",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VP22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VP22"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q9VP22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VP22"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9VP22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VP22"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q9VP22",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VP22"
}
]
}
]
},
{
"uniprot_ac": "Q9VPC0",
"gene_name": "Pitslre",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VPC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VPC0"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9VPC0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VPC0"
}
]
}
]
},
{
"uniprot_ac": "Q9VR42",
"gene_name": "Dmel\\CG3008",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VR42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VR42"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VR42",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VR42"
}
]
}
]
},
{
"uniprot_ac": "Q9VRJ6",
"gene_name": "Tcs5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VRJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VRJ6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VRJ6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VRJ6"
}
]
}
]
},
{
"uniprot_ac": "Q9VT57",
"gene_name": "Cdk8",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VT57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VT57"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].",
"evidence": [
{
"id": "Q9VT57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VT57"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9VT57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VT57"
}
]
},
{
"ec_number": "2.7.11.23",
"activity": "",
"evidence": [
{
"id": "Q9VT57",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VT57"
}
]
}
]
},
{
"uniprot_ac": "Q9VTL5",
"gene_name": "RIOK1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VTL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VTL5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VTL5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VTL5"
}
]
}
]
},
{
"uniprot_ac": "Q9VUQ9",
"gene_name": "dop",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VUQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VUQ9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VUQ9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VUQ9"
}
]
}
]
},
{
"uniprot_ac": "Q9VUV4",
"gene_name": "sff",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VUV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VUV4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VUV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VUV4"
}
]
}
]
},
{
"uniprot_ac": "Q9VW24",
"gene_name": "wnd",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VW24",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VW24"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9VW24",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VW24"
}
]
}
]
},
{
"uniprot_ac": "Q9VXE3",
"gene_name": "Rok",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VXE3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXE3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VXE3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXE3"
}
]
}
]
},
{
"uniprot_ac": "Q9VXE5",
"gene_name": "mbt",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VXE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXE5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VXE5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXE5"
}
]
}
]
},
{
"uniprot_ac": "Q9VXG8",
"gene_name": "mei-41",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VXG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXG8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VXG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXG8"
}
]
}
]
},
{
"uniprot_ac": "Q9VXN5",
"gene_name": "Dmel\\CG8565",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VXN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXN5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VXN5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VXN5"
}
]
}
]
},
{
"uniprot_ac": "Q9VZI2",
"gene_name": "Ack",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "Q9VZI2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VZI2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9VZI2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VZI2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9VZI2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VZI2"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "Q9VZI2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9VZI2"
}
]
}
]
},
{
"uniprot_ac": "Q9W002",
"gene_name": "msn",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9W002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W002"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9W002",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W002"
}
]
}
]
},
{
"uniprot_ac": "Q9W0V1",
"gene_name": "Pdk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9W0V1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W0V1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9W0V1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W0V1"
}
]
}
]
},
{
"uniprot_ac": "Q9W1B0",
"gene_name": "gek",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9W1B0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W1B0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9W1B0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W1B0"
}
]
}
]
},
{
"uniprot_ac": "Q9W354",
"gene_name": "Erk7",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9W354",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W354"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9W354",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W354"
}
]
}
]
},
{
"uniprot_ac": "Q9W3N8",
"gene_name": "Nek2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9W3N8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W3N8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9W3N8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9W3N8"
}
]
}
]
},
{
"uniprot_ac": "Q9WTK7",
"gene_name": "Stk11",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WTK7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTK7"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9WTK7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTK7"
}
]
}
]
},
{
"uniprot_ac": "Q9WTQ0",
"gene_name": "Prkcq",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WTQ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTQ0"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q9WTQ0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTQ0"
}
]
}
]
},
{
"uniprot_ac": "Q9WTQ1",
"gene_name": "Prkd1",
"activity": [
{
"ec_number": "2.7.11.13",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WTQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTQ1"
}
]
},
{
"ec_number": "2.7.11.13",
"activity": "",
"evidence": [
{
"id": "Q9WTQ1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTQ1"
}
]
}
]
},
{
"uniprot_ac": "Q9WTR2",
"gene_name": "Map3k6",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WTR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTR2"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9WTR2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTR2"
}
]
}
]
},
{
"uniprot_ac": "Q9WTU6",
"gene_name": "Mapk9",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WTU6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTU6"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9WTU6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTU6"
}
]
}
]
},
{
"uniprot_ac": "Q9WTY9",
"gene_name": "Mapk13",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WTY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTY9"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9WTY9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WTY9"
}
]
}
]
},
{
"uniprot_ac": "Q9WUA6",
"gene_name": "Akt3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WUA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUA6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9WUA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUA6"
}
]
}
]
},
{
"uniprot_ac": "Q9WUI1",
"gene_name": "Mapk11",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WUI1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUI1"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9WUI1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUI1"
}
]
}
]
},
{
"uniprot_ac": "Q9WUL6",
"gene_name": "Map3k14",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WUL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUL6"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9WUL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUL6"
}
]
}
]
},
{
"uniprot_ac": "Q9WUN2",
"gene_name": "Tbk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WUN2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUN2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9WUN2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUN2"
}
]
}
]
},
{
"uniprot_ac": "Q9WUT3",
"gene_name": "Rps6ka2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WUT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUT3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9WUT3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WUT3"
}
]
}
]
},
{
"uniprot_ac": "Q9WV60",
"gene_name": "Gsk3b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WV60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV60"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl-[tau protein].",
"evidence": [
{
"id": "Q9WV60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV60"
}
]
},
{
"ec_number": "2.7.11.26",
"activity": "",
"evidence": [
{
"id": "Q9WV60",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WV60"
}
]
}
]
},
{
"uniprot_ac": "Q9WVC6",
"gene_name": "Sgk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WVC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVC6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9WVC6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVC6"
}
]
}
]
},
{
"uniprot_ac": "Q9WVS4",
"gene_name": "Mok",
"activity": [
{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WVS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVS4"
}
]
},
{
"ec_number": "2.7.11.22",
"activity": "",
"evidence": [
{
"id": "Q9WVS4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVS4"
}
]
}
]
},
{
"uniprot_ac": "Q9WVS7",
"gene_name": "Map2k5",
"activity": [
{
"ec_number": "2.7.12.2",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WVS7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVS7"
}
]
},
{
"ec_number": "2.7.12.2",
"activity": "",
"evidence": [
{
"id": "Q9WVS7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVS7"
}
]
}
]
},
{
"uniprot_ac": "Q9WVS8",
"gene_name": "Mapk7",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9WVS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVS8"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9WVS8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVS8"
}
]
}
]
},
{
"uniprot_ac": "Q9Y243",
"gene_name": "AKT3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y243",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y243"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y243",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y243"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2H1",
"gene_name": "STK38L",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y2H1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2H1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y2H1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2H1"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2H9",
"gene_name": "MAST1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y2H9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2H9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y2H9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2H9"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2I7",
"gene_name": "PIKFYVE",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y2I7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2I7"
}
]
},
{
"ec_number": "2.7.1.150",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q9Y2I7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2I7"
}
]
},
{
"ec_number": "2.7.1.150",
"activity": "",
"evidence": [
{
"id": "Q9Y2I7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2I7"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2K2",
"gene_name": "SIK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y2K2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2K2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y2K2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2K2"
}
]
}
]
},
{
"uniprot_ac": "Q9Y2U5",
"gene_name": "MAP3K2",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y2U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2U5"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9Y2U5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y2U5"
}
]
}
]
},
{
"uniprot_ac": "Q9Y3S1",
"gene_name": "WNK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y3S1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y3S1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y3S1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y3S1"
}
]
}
]
},
{
"uniprot_ac": "Q9Y463",
"gene_name": "DYRK1B",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y463",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y463"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q9Y463",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y463"
}
]
}
]
},
{
"uniprot_ac": "Q9Y4B6",
"gene_name": "DCAF1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y4B6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y4B6"
}
]
}
]
},
{
"uniprot_ac": "Q9Y4K4",
"gene_name": "MAP4K5",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y4K4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y4K4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y4K4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y4K4"
}
]
}
]
},
{
"uniprot_ac": "Q9Y572",
"gene_name": "RIPK3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y572"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y572"
}
]
}
]
},
{
"uniprot_ac": "Q9Y5S2",
"gene_name": "CDC42BPB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y5S2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y5S2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y5S2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y5S2"
}
]
}
]
},
{
"uniprot_ac": "Q9Y6E0",
"gene_name": "STK24",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y6E0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6E0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y6E0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6E0"
}
]
}
]
},
{
"uniprot_ac": "Q9Y6M4",
"gene_name": "CSNK1G3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y6M4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6M4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y6M4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6M4"
}
]
}
]
},
{
"uniprot_ac": "Q9Y6R4",
"gene_name": "MAP3K4",
"activity": [
{
"ec_number": "2.7.11.25",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y6R4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6R4"
}
]
},
{
"ec_number": "2.7.11.25",
"activity": "",
"evidence": [
{
"id": "Q9Y6R4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6R4"
}
]
}
]
},
{
"uniprot_ac": "Q9Y6S9",
"gene_name": "RPS6KL1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Y6S9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6S9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Y6S9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Y6S9"
}
]
}
]
},
{
"uniprot_ac": "Q9Z0G2",
"gene_name": "Srpk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z0G2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z0G2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z0G2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z0G2"
}
]
}
]
},
{
"uniprot_ac": "Q9Z0H0",
"gene_name": "Cdc7",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z0H0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z0H0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z0H0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z0H0"
}
]
}
]
},
{
"uniprot_ac": "Q9Z0R0",
"gene_name": "Haspin",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z0R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z0R0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z0R0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z0R0"
}
]
}
]
},
{
"uniprot_ac": "Q9Z188",
"gene_name": "Dyrk1b",
"activity": [
{
"ec_number": "2.7.12.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z188",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z188"
}
]
},
{
"ec_number": "2.7.12.1",
"activity": "",
"evidence": [
{
"id": "Q9Z188",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z188"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1B7",
"gene_name": "Mapk13",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1B7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1B7"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9Z1B7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1B7"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1J2",
"gene_name": "Nek4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1J2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1J2"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z1J2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1J2"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1L0",
"gene_name": "Pik3cb",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1L0"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q9Z1L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1L0"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "Q9Z1L0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1L0"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1M4",
"gene_name": "Rps6kb2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1M4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1M4"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z1M4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1M4"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1S0",
"gene_name": "Bub1b",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1S0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1S0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z1S0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1S0"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1T6",
"gene_name": "Pikfyve",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1T6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1T6"
}
]
},
{
"ec_number": "2.7.1.150",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "Q9Z1T6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1T6"
}
]
},
{
"ec_number": "2.7.1.150",
"activity": "",
"evidence": [
{
"id": "Q9Z1T6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1T6"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1W9",
"gene_name": "Stk39",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1W9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1W9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z1W9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1W9"
}
]
}
]
},
{
"uniprot_ac": "Q9Z1Z1",
"gene_name": "Eif2ak3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z1Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1Z1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z1Z1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z1Z1"
}
]
}
]
},
{
"uniprot_ac": "Q9Z265",
"gene_name": "Chek2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z265"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z265",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z265"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2A0",
"gene_name": "Pdpk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2A0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2A0"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2A0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2A0"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2A6",
"gene_name": "Mapk15",
"activity": [
{
"ec_number": "2.7.11.24",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2A6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2A6"
}
]
},
{
"ec_number": "2.7.11.24",
"activity": "",
"evidence": [
{
"id": "Q9Z2A6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2A6"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2B5",
"gene_name": "Eif2ak3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2B5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2B5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2B5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2B5"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2B9",
"gene_name": "Rps6ka4",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2B9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2B9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2B9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2B9"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2E3",
"gene_name": "Ern2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2E3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2E3"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2E3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2E3"
}
]
},
{
"ec_number": "3.1.26.-",
"activity": "",
"evidence": [
{
"id": "Q9Z2E3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2E3"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2P5",
"gene_name": "Ripk3",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2P5"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2P5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2P5"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2R9",
"gene_name": "Eif2ak1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2R9"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2R9"
}
]
}
]
},
{
"uniprot_ac": "Q9Z2W1",
"gene_name": "Stk25",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z2W1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2W1"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z2W1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z2W1"
}
]
}
]
},
{
"uniprot_ac": "Q9Z335",
"gene_name": "Sbk1",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q9Z335",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z335"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q9Z335",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9Z335"
}
]
}
]
},
{
"uniprot_ac": "X2JAG8",
"gene_name": "Prp4k",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "X2JAG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/X2JAG8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "X2JAG8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/X2JAG8"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [],
"cluster_types": [
{
"name": "isoformset.uniprotkb",
"label": "Isoforms"
},
{
"name": "homologset.mgi",
"label": "MGI Homologs"
},
{
"name": "homologset.oma",
"label": "OMA Homologs"
}
],
"sequence_features": {
"n_linked_sites": [],
"o_linked_sites": [
227
],
"snv_sites": [
23,
142,
175,
186,
227,
250,
257,
283
],
"glycation_sites": [],
"phosphorylation_sites": [
29,
43,
233,
244,
252,
257,
258,
259,
260,
268,
269,
289,
291,
294,
295,
296,
301,
303,
338,
339,
340,
341,
471,
491,
494,
497,
499,
619,
621,
624,
641,
642
],
"sequon_annotation_sites": [
{
"start_pos": 198,
"end_pos": 200
},
{
"start_pos": 241,
"end_pos": 243
},
{
"start_pos": 299,
"end_pos": 301
},
{
"start_pos": 617,
"end_pos": 619
}
]
},
"section_stats": [
{
"table_id": "glycosylation",
"table_stats": [
{
"field": "total",
"count": 1
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 1
},
{
"field": "o_linked_glycan_sites",
"count": 1
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_reported_with_glycan",
"table_stats": [
{
"field": "total",
"count": 1
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 1
},
{
"field": "o_linked_glycan_sites",
"count": 1
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_predicted",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_automatic_literature_mining",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "phosphorylation",
"table_stats": [
{
"field": "total",
"count": 74
},
{
"field": "total_sites",
"count": 32
}
],
"sort_fields": [
"start_pos",
"end_pos",
"kinase_uniprot_canonical_ac",
"kinase_gene_name",
"residue",
"comment",
"site_lbl"
]
},
{
"table_id": "snv",
"table_stats": [
{
"field": "total",
"count": 8
},
{
"field": "total_sites",
"count": 8
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "snv_disease",
"table_stats": [
{
"field": "total",
"count": 2
},
{
"field": "total_sites",
"count": 2
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "snv_non_disease",
"table_stats": [
{
"field": "total",
"count": 6
},
{
"field": "total_sites",
"count": 6
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "publication",
"table_stats": [
{
"field": "total",
"count": 507
}
],
"sort_fields": [
"title",
"journal",
"date",
"authors"
]
}
]
}