{ "uniprot_canonical_ac": "P02750-1", "uniprot_ac": "P02750", "uniprot_id": "A2GL_HUMAN", "mass": { "chemical_mass": 38178.0, "monoisotopic_mass": 38178.0 }, "refseq": { "ac": "NP_443204", "name": "leucine-rich alpha-2-glycoprotein precursor", "summary": "The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, "gene_names": [ { "name": "LRG1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P02750", "id": "P02750" }, { "name": "HMFT1766; LRG", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204", "id": "NP_443204" }, { "name": "LRG1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204", "id": "NP_443204" }, { "name": "LRG", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P02750", "id": "P02750" } ], "protein_names": [ { "name": "Leucine-rich alpha-2-glycoprotein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P02750" }, { "name": "2310031E04Rik; 1300008B03Rik; leucine rich alpha 2 glycoprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204", "id": "NP_443204" }, { "name": "LRG", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P02750" }, { "name": "leucine-rich alpha-2-glycoprotein precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204", "id": "NP_443204" } ], "function": [ { "annotation": "CDNA clones for human leucine-rich alpha2-glycoprotein were isolated. LRG expression was up-regulated during neutrophil differentiation but down-regulated during monocytic differentiation. The hLRG gene was localized to chromosome 19p13.3.", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, { "database": "PubMed", "id": "12223515", "url": "https://glygen.org/publication/PubMed/12223515" } ] }, { "annotation": "LRG1 Is Involved in the Progression of Ovarian Cancer via Modulating FAK/AKT Signaling Pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, { "database": "PubMed", "id": "37258465", "url": "https://glygen.org/publication/PubMed/37258465" } ] }, { "annotation": "LRG1 Promotes ECM Integrity by Activating the TGF-beta Signaling Pathway in Fibroblasts. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, { "database": "PubMed", "id": "37569820", "url": "https://glygen.org/publication/PubMed/37569820" } ] }, { "annotation": "Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, { "database": "PubMed", "id": "38003727", "url": "https://glygen.org/publication/PubMed/38003727" } ] }, { "annotation": "Relationship between plasma leucine-rich alpha-2-glycoprotein 1 and urinary albumin excretion in patients with type 2 diabetes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, { "database": "PubMed", "id": "37916147", "url": "https://glygen.org/publication/PubMed/37916147" } ] }, { "annotation": "Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" }, { "database": "PubMed", "id": "37089863", "url": "https://glygen.org/publication/PubMed/37089863" } ] }, { "annotation": "The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs771381352", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771381352" }, { "id": "rs771381352", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771381352" }, { "id": "rs771381352", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs771381352#frequency_tab" }, { "id": "rs771381352", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs771381352" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 186, "end_pos": 186, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NFT->SFT).", "chr_id": "19", "chr_pos": "4538427", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N186", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P02750", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P02750" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 188, "end_pos": 188, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NFT->NFI).", "chr_id": "19", "chr_pos": "4538421", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T188", "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer 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"sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKL->NKS).", "chr_id": "19", "chr_pos": "4538313", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L224", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778743033", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778743033" }, { "id": "rs778743033", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778743033" }, { "id": "rs778743033", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778743033" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 246, "end_pos": 246, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGN->NGS).", "chr_id": "19", "chr_pos": "4538247", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N246", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs561264361", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs561264361" }, { "id": "rs561264361", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs561264361" }, { "id": "rs561264361", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs561264361" }, { "id": "rs561264361", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs561264361#frequency_tab" }, { "id": "rs561264361", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs561264361" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 266, "end_pos": 266, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "19", "chr_pos": "4538188", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "D266", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs774321622", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774321622" }, { "id": "rs774321622", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774321622" }, { "id": "rs774321622", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs774321622" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 269, "end_pos": 269, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNS->SNS).", "chr_id": "19", "chr_pos": "4538178", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N269", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778270480", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778270480" }, { "id": "rs778270480", "database": "ExAC", "url": 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"https://www.ncbi.nlm.nih.gov/snp/rs751236906#frequency_tab" }, { "id": "rs751236906", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs751236906" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 306, "end_pos": 306, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->KLS).", "chr_id": "19", "chr_pos": "4538066", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N306", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "P02750", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P02750" }, { "id": "rs749415690", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749415690" }, { "id": "rs749415690", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749415690" }, { "id": "rs749415690", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749415690" }, { "id": "rs749415690", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs749415690#frequency_tab" }, { "id": "rs749415690", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs749415690" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 327, "end_pos": 327, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "M", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NDT->NDM).", "chr_id": "19", "chr_pos": "4538004", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T327", "disease": [ { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1315194303", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1315194303" }, { "id": "rs1315194303", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1315194303" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 37, "end_pos": 37, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P02750", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02750" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of 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A., Afonso L. P., Santos L. L., Pinto de Sousa J., Mandel U., Clausen H., Vakhrushev S. Y., Reis C. A.", "evidence": [ { "database": "UniCarbKB", "id": "P02750", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1074/mcp.M114.046862", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" } ] }, { "title": "Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation.", "journal": "J. Leukoc. Biol.", "date": "2002", "authors": "O'Donnell LC, Druhan LJ, Avalos BR", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" }, { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" } ], "reference": [ { "type": "PubMed", "id": "12223515", "url": "https://glygen.org/publication/PubMed/12223515" } ] }, { "title": "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.", "journal": "Proteomics", "date": "2004", "authors": "Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wisniewski JR", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750#ptm_processing" }, { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "reference": [ { "type": "PubMed", "id": "14760718", "url": "https://glygen.org/publication/PubMed/14760718" } ] }, { "title": "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.", "journal": "Journal of proteome research", "date": "2005", "authors": "Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750#ptm_processing" }, { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "reference": [ { "type": "PubMed", "id": "16335952", "url": "https://glygen.org/publication/PubMed/16335952" } ] }, { "title": "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.", "journal": "Journal of proteome research", "date": "2006", "authors": "Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750#ptm_processing" }, { "database": "UniProtKB", "id": "P02750", "url": 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Guimaraes V, Quina D, Nahas W, Schwammle V, Srougi M, Leite KRM, Thaysen-Andersen M, Larsen MR, Palmisano G", "evidence": [ { "database": "GlyConnect", "id": "676", "url": "https://glyconnect.expasy.org/browser/proteins/676" } ], "reference": [ { "type": "PubMed", "id": "30237853", "url": "https://glygen.org/publication/PubMed/30237853" } ] }, { "title": "Leucine-Rich Alpha-2-Glycoprotein 1 in Serum Is a Possible Biomarker to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer.", "journal": "Biological & pharmaceutical bulletin", "date": "2019", "authors": "Nambu M, Masuda T, Ito S, Kato K, Kojima T, Daiko H, Ito Y, Honda K, Ohtsuki S", "evidence": [ { "database": "GlyGen", "id": "A0228", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "31582665", "url": "https://glygen.org/publication/PubMed/31582665" } ] }, { "title": "Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes.", "journal": "Journal of proteome research", "date": "2020", "authors": "Zhu J, Lin YH, Dingess KA, Mank M, Stahl B, Heck AJR", "evidence": [ { "database": "GlyConnect", "id": "676", "url": "https://glyconnect.expasy.org/browser/proteins/676" } ], "reference": [ { "type": "PubMed", "id": "32125861", "url": "https://glygen.org/publication/PubMed/32125861" } ] }, { "title": "Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence.", "journal": "Cancer research communications", "date": "2023-04", "authors": "Hoefsmit Esmee P, V\u00f6llmy Franziska, Rozeman Elisa A, Reijers Irene L M, Versluis Judith M, Hoekman Liesbeth, van Akkooi Alexander C J, Long Georgina V, Schadendorf Dirk, Dummer Reinhard, Altelaar Maarten, Blank Christian U", "evidence": [ { "database": "RefSeq", "id": "NP_443204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443204" } ], "reference": [ { "type": "PubMed", "id": 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"brown fat cell differentiation", "id": "GO:0050873", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050873", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "response to bacterium", "id": "GO:0009617", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell proliferation", "id": "GO:0001938", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001938", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "wound healing, spreading of epidermal cells", "id": "GO:0035313", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035313", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "positive regulation of epithelial to mesenchymal transition", "id": "GO:0010718", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010718", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "positive regulation of keratinocyte proliferation", "id": "GO:0010838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010838", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "positive regulation of epithelial cell proliferation involved in wound healing", "id": "GO:0060054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060054", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "leukocyte adhesion to vascular endothelial cell", "id": "GO:0061756", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061756", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "ficolin-1-rich granule lumen", "id": "GO:1904813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904813", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "specific granule lumen", "id": "GO:0035580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035580", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "tertiary granule lumen", "id": "GO:1904724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904724", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "type II transforming growth factor beta receptor binding", "id": "GO:0005114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005114", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" }, { "name": "type I transforming growth factor beta receptor binding", "id": "GO:0034713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034713", "evidence": [ { "database": "UniProtKB", "id": "P02750", "url": "https://www.uniprot.org/uniprot/P02750" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "leucine-rich alpha-2-glycoprotein N-glycosylated 1 (human)", "definition": "A leucine-rich alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-186 of the amino acid sequence represented by UniProtKB:P02750-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P02750-1, Asn-186, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:19838169]", "evidence": [ { "id": "PR:000052770", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052770" } ] }, { "name": "leucine-rich alpha-2-glycoprotein N-glycosylated 2 (human)", "definition": "A leucine-rich alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-269 of the amino acid sequence represented by UniProtKB:P02750-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P02750-1, Asn-269, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000052771", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052771" } ] }, { "name": "leucine-rich alpha-2-glycoprotein N-glycosylated 3 (human)", "definition": "A leucine-rich alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-269 of the amino acid sequence represented by UniProtKB:P02750-1, in which the glycan composition is represented by GlyTouCan:G67324HN. Example: UniProtKB:P02750-1, Asn-269, MOD:00160~GNO:G67324HN. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000052772", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052772" } ] }, { "name": "leucine-rich alpha-2-glycoprotein N-glycosylated 4 (human)", "definition": "A leucine-rich alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-325 of the amino acid sequence represented by UniProtKB:P02750-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P02750-1, Asn-325, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000052773", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052773" } ] }, { "name": "leucine-rich alpha-2-glycoprotein N-glycosylated 5 (human)", "definition": "A leucine-rich alpha-2-glycoprotein (human) that has been N-glycosylated at the residue equivalent to Asn-325 of the amino acid sequence represented by UniProtKB:P02750-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P02750-1, Asn-325, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000052774", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052774" } ] } ], "site_annotation": [ { "start_pos": 186, "end_pos": 188, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 306, "end_pos": 308, "annotation": "n_glycosylation_sequon" }, { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 79, "end_pos": 81, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [ { "assessed_biomarker_entity": "Leucine-rich alpha-2-glycoprotein 1 (LRAG1)", "biomarker_id": "A0228", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "31582665", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31582665" } ], 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neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": 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"id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": 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