{ "uniprot_canonical_ac": "P02671-1", "uniprot_ac": "P02671", "uniprot_id": "FIBA_HUMAN", "mass": { "chemical_mass": 94973.0, "monoisotopic_mass": 94973.0 }, "refseq": { "ac": "NP_000499", "name": "fibrinogen alpha chain isoform alpha-E preproprotein", "summary": "This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" }, "gene_names": [ { "name": "FGA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P02671", "id": "P02671" }, { "name": "FGA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499", "id": "NP_000499" }, { "name": "Fib2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499", "id": "NP_000499" } ], "protein_names": [ { "name": "Fibrinogen alpha chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P02671" }, { "name": "fibrinogen alpha chain isoform alpha-E preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499", "id": "NP_000499" }, { "name": "fibrinogen, A alpha polypeptide", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499", "id": "NP_000499" } ], "function": [ { "annotation": "Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671#function" }, { "database": "UniProtKB", "id": "E9PV24", "url": "https://www.uniprot.org/uniprot/E9PV24#function" } ] }, { "annotation": "Fibrinogen-Aalpha THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey.", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" }, { "database": "PubMed", "id": "36856592", "url": "https://glygen.org/publication/PubMed/36856592" } ] }, { "annotation": "Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients.", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" }, { "database": "PubMed", "id": "36933991", "url": "https://glygen.org/publication/PubMed/36933991" } ] }, { "annotation": "Regulation of the fibrinogen genes from proximal promoters and enhancers, the influence of acute-phase stimulation, post-transcriptional regulation by miRNAs and functional regulatory variants identified in genetic studies. Review. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" }, { "database": "PubMed", "id": "22836683", "url": "https://glygen.org/publication/PubMed/22836683" } ] }, { "annotation": "This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" } ] }, { "annotation": "Two Novel Heterozygous Mutations (p.gammaPhe230Val and p.AalphaAsn839Thr) Cause Hereditary Hypodysfibrinogenemia in Two Chinese Independent Families.", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" }, { "database": "PubMed", "id": "36599322", "url": "https://glygen.org/publication/PubMed/36599322" } ] }, { "annotation": "[Genetic analysis of a Chinese pedigree affected with Congenital dysfibrinogenemia due to variant of FGG gene].", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" }, { "database": "PubMed", "id": "37906135", "url": "https://glygen.org/publication/PubMed/37906135" } ] } ], "disease": [ { "disease_id": "DOID:0050636", "recommended_name": { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "familial visceral amyloidosis", "description": "An amyloidosis that is characterized by the abnormal deposition of amyloid proteins that is located_in the visceral organs, primarily the kidneys." }, "synonyms": [ { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "AMYLOIDOSIS, FAMILIAL RENAL", "description": "" }, { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "German type amyloidosis", "description": "" }, { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "OSTERTAG TYPE AMYLOIDOSIS", "description": "" }, { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "systemic nonneuropathic amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "familial visceral amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "German type amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "Ostertag type amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, 3 or more types", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, Ostertag type", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, familial renal", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, renal", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "familial amyloid nephropathy", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "familial renal amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "hereditary amyloid nephropathy", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "hereditary renal amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "systemic nonneuropathic amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis 8", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis VIII", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis familial renal", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis familial visceral", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis systemic nonneuropathic", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, familial visceral", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, systemic Nonneuropathic", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "hereditary amyloidosis with primary renal involement", "description": "" }, { "id": "MIM:105200", "resource": "MIM", "url": "https://www.omim.org/entry/105200", "name": "Amyloidosis 8", "description": "Amyloidosis 8" } ], "evidence": [ { "id": "105200", "database": "MIM", "url": "https://www.omim.org/entry/105200" } ] }, { "disease_id": "DOID:2236", "recommended_name": { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "congenital afibrinogenemia", "description": "A blood coagulation disease that is characterized by an impaired blood clotting resulting from a lack deficiency of a the fibrinogen protein (coagulation factor I)." }, "synonyms": [ { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "Factor I deficiency", "description": "" }, { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "Fibrinogen deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "congenital afibrinogenemia", "description": "Familial afibrinogenemia is a coagulation disorder characterized by bleeding symptoms due to a complete absence of circulating fibrinogen." }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "fibrinogen deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "factor I deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia congenital", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia, congenital", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "familial afibrinogenemia", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "hypofibrinogenemia, congenital", "description": "" }, { "id": "MIM:202400", "resource": "MIM", "url": "https://www.omim.org/entry/202400", "name": "Congenital afibrinogenemia", "description": "Congenital afibrinogenemia" } ], "evidence": [ { "id": "202400", "database": "MIM", "url": "https://www.omim.org/entry/202400" } ] }, { "disease_id": "MONDO:0014452", "recommended_name": { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "familial dysfibrinogenemia", "description": "Familial dysfibrinogenemia is a coagulation disorder characterized by a bleeding tendency due to a functional anomaly of circulating fibrinogen." }, "synonyms": [ { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "dysfibrinogenemia", "description": "" }, { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "familial dysfibrinogenemia", "description": "" }, { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "hypodysfibrinogenemia", "description": "" }, { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "congenital dysfibrinogenemia", "description": "" }, { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "dysfibrinogenemia, congenital", "description": "" }, { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "dysfibrinogenemia, familial", "description": "" }, { "id": "MONDO:0014452", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014452", "name": "hypodysfibrinogenemia, congenital", "description": "" }, { "id": "MIM:616004", "resource": "MIM", "url": "https://www.omim.org/entry/616004", "name": "Dysfibrinogenemia, congenital", "description": "Dysfibrinogenemia, congenital" } ], "evidence": [ { "id": "616004", "database": "MIM", "url": "https://www.omim.org/entry/616004" } ] } ], "snv": [ { "evidence": [ { "id": "rs1045071000", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1045071000" }, { "id": "rs1045071000", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1045071000" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 110, "end_pos": 110, "sequence_org": "M", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIM->NIT).", "chr_id": "4", "chr_pos": "154588828", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "M110", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs886059153", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs886059153" }, { "id": "rs886059153", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs886059153#frequency_tab" }, { "id": "rs886059153", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs886059153" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 116, "end_pos": 116, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DFS->NFS).", "chr_id": "4", "chr_pos": "154588811", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D116", "disease": [ { "disease_id": "DOID:2236", "recommended_name": { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "congenital afibrinogenemia", "description": "A blood coagulation disease that is characterized by an impaired blood clotting resulting from a lack deficiency of a the fibrinogen protein (coagulation factor I)." }, "synonyms": [ { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "Factor I deficiency", "description": "" }, { "id": "DOID:2236", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2236", "name": "Fibrinogen deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "congenital afibrinogenemia", "description": "Familial afibrinogenemia is a coagulation disorder characterized by bleeding symptoms due to a complete absence of circulating fibrinogen." }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "fibrinogen deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "factor I deficiency", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia congenital", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "afibrinogenemia, congenital", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "familial afibrinogenemia", "description": "" }, { "id": "MONDO:0008737", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008737", "name": "hypofibrinogenemia, congenital", "description": "" }, { "id": "MIM:202400", "resource": "MIM", "url": "https://www.omim.org/entry/202400", "name": "Congenital afibrinogenemia", "description": "Congenital afibrinogenemia" } ] }, { "disease_id": "DOID:0050636", "recommended_name": { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "familial visceral amyloidosis", "description": "An amyloidosis that is characterized by the abnormal deposition of amyloid proteins that is located_in the visceral organs, primarily the kidneys." }, "synonyms": [ { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "AMYLOIDOSIS, FAMILIAL RENAL", "description": "" }, { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "German type amyloidosis", "description": "" }, { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "OSTERTAG TYPE AMYLOIDOSIS", "description": "" }, { "id": "DOID:0050636", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050636", "name": "systemic nonneuropathic amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "familial visceral amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "German type amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "Ostertag type amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, 3 or more types", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, Ostertag type", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, familial renal", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, renal", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "familial amyloid nephropathy", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "familial renal amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "hereditary amyloid nephropathy", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "hereditary renal amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "systemic nonneuropathic amyloidosis", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis 8", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis VIII", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis familial renal", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis familial visceral", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis systemic nonneuropathic", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, familial visceral", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "amyloidosis, systemic Nonneuropathic", "description": "" }, { "id": "MONDO:0007099", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007099", "name": "hereditary amyloidosis with primary renal involement", "description": "" }, { "id": "MIM:105200", "resource": "MIM", "url": "https://www.omim.org/entry/105200", "name": "Amyloidosis 8", "description": "Amyloidosis 8" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs555704618", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs555704618" }, { "id": "rs555704618", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs555704618" }, { "id": "rs555704618", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs555704618" }, { "id": "rs555704618", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs555704618#frequency_tab" }, { "id": "rs555704618", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs555704618" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 283, "end_pos": 283, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->K).", "chr_id": "4", "chr_pos": "154586581", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "T283", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs555704618", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs555704618" }, { "id": "rs555704618", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs555704618" }, { "id": "rs555704618", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs555704618" }, { "id": "rs555704618", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs555704618#frequency_tab" }, { "id": "rs555704618", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs555704618" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 283, "end_pos": 283, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->M).", "chr_id": "4", "chr_pos": "154586581", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "T283", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778270823", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778270823" }, { "id": "rs778270823", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778270823" }, { "id": "rs778270823", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778270823" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 297, "end_pos": 297, "sequence_org": "S", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->A).", "chr_id": "4", "chr_pos": "154586540", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S297", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs756998245", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756998245" }, { "id": "rs756998245", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756998245" }, { "id": "rs756998245", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756998245" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 297, "end_pos": 297, "sequence_org": "S", "sequence_mut": "C", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->C).", "chr_id": "4", "chr_pos": "154586539", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S297", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1190462482", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1190462482" }, { "id": "rs1190462482", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1190462482" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 315, "end_pos": 315, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "4", "chr_pos": "154586486", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T315", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs117761234", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs117761234" }, { "id": "rs117761234", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs117761234" }, { "id": "rs117761234", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs117761234" }, { "id": "rs117761234", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs117761234" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 315, "end_pos": 315, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "4", "chr_pos": "154586485", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "T315", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs772322188", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772322188" }, { "id": "rs772322188", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772322188" }, { "id": "rs772322188", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs772322188" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 338, "end_pos": 338, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).", "chr_id": "4", "chr_pos": "154586415", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S338", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1376400427", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1376400427" }, { "id": "rs1376400427", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1376400427#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 341, "end_pos": 341, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "4", "chr_pos": "154586408", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T341", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs534934417", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs534934417" }, { "id": "rs534934417", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs534934417" }, { "id": "rs534934417", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs534934417" }, { "id": "rs534934417", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs534934417" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 348, "end_pos": 348, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NQN->NQS).", "chr_id": "4", "chr_pos": "154586386", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "N348", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs747770355", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747770355" }, { "id": "rs747770355", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747770355" }, { "id": "rs747770355", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs747770355" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 351, "end_pos": 351, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).", "chr_id": "4", "chr_pos": "154586376", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S351", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1407449111", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1407449111" }, { "id": "rs1407449111", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1407449111#frequency_tab" }, { "id": "rs1407449111", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1407449111" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 357, "end_pos": 357, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "4", "chr_pos": "154586360", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T357", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs764131074", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs764131074" }, { "id": "rs764131074", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs764131074" }, { "id": "rs764131074", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs764131074" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 357, "end_pos": 357, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "4", "chr_pos": "154586359", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T357", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1217192306", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1217192306" }, { "id": "rs1217192306", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1217192306#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 408, "end_pos": 408, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNP->NNS).", "chr_id": "4", "chr_pos": "154586207", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P408", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs121909610", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs121909610" }, { "id": "rs121909610", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs121909610" }, { "id": "1675636", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/1675636" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 453, "end_pos": 453, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (STT->NTT).", "chr_id": "4", "chr_pos": "154586071", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S453", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1163177532", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1163177532" }, { "id": "rs1163177532", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1163177532#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 524, "end_pos": 524, "sequence_org": "S", "sequence_mut": "L", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->L).", "chr_id": "4", "chr_pos": "154585858", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S524", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765169639", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765169639" }, { "id": "rs765169639", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765169639" }, { "id": "rs765169639", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765169639" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 546, "end_pos": 546, "sequence_org": "S", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->A).", "chr_id": "4", "chr_pos": "154585793", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S546", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs765169639", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765169639" }, { "id": "rs765169639", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs765169639" }, { "id": "rs765169639", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs765169639" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 546, "end_pos": 546, "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->P).", "chr_id": "4", "chr_pos": "154585793", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S546", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs187021713", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs187021713" }, { "id": "rs187021713", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs187021713" }, { "id": "rs187021713", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs187021713" }, { "id": "rs187021713", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs187021713" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 557, "end_pos": 557, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "4", "chr_pos": "154585760", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "T557", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs976135700", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs976135700" }, { "id": "rs976135700", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs976135700#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 557, "end_pos": 557, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->R).", "chr_id": "4", "chr_pos": "154585759", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T557", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1170342579", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1170342579" }, { "id": "rs1170342579", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1170342579#frequency_tab" }, { "id": "rs1170342579", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1170342579" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 562, "end_pos": 562, "sequence_org": "S", "sequence_mut": "Y", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->Y).", "chr_id": "4", "chr_pos": "154585744", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S562", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs776656266", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776656266" }, { "id": "rs776656266", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776656266" }, { "id": "rs776656266", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs776656266" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 586, "end_pos": 586, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).", "chr_id": "4", "chr_pos": "154585671", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S586", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760669110", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760669110" }, { "id": "rs760669110", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760669110" }, { "id": "rs760669110", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760669110" }, { "id": "rs760669110", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs760669110#frequency_tab" }, { "id": "rs760669110", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760669110" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 616, "end_pos": 616, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "4", "chr_pos": "154585583", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T616", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs763664594", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs763664594" }, { "id": "rs763664594", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs763664594" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 688, "end_pos": 688, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRT->NRN).", "chr_id": "4", "chr_pos": "154584662", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T688", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs971302509", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs971302509" }, { "id": "rs971302509", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs971302509#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 783, "end_pos": 783, "sequence_org": "M", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNM->NNT).", "chr_id": "4", "chr_pos": "154584377", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "M783", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs754563069", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754563069" }, { "id": "rs754563069", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754563069" }, { "id": "rs754563069", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs754563069" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 818, "end_pos": 818, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLN->NLS).", "chr_id": "4", "chr_pos": "154584272", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N818", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "84.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "43.23", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "79.5", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "63.02", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "77.11", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "46.72", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "59.19", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "63.55", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "48.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "58.21", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "99.94", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "59.13", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "51.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "P02671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P02671" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "common_name": "Human" } ], "gene": [ { "name": "FGA", "url": "https://www.uniprot.org/uniprot/P02671", "locus": { "chromosome": "4", "start_pos": 12618, "end_pos": 5001, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "LRG_557", "url": "https://www.ensembl.org/id/LRG_557" } ] } } ], "crossref": [ { "id": "ENSG00000171560", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171560", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL2364709", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2364709", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "FGA", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=FGA", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "2243", "url": "https://www.ncbi.nlm.nih.gov/gene/2243", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1238", "url": "https://glyconnect.expasy.org/browser/proteins/1238", "database": "GlyConnect", "categories": [ "Glycoproteomics", "Glycan" ] }, { "id": "157", "url": "https://glyconnect.expasy.org/browser/proteins/157", "database": "GlyConnect", "categories": [ "Glycoproteomics", "Glycan" ] }, { "id": "3661", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3661", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "P02671", "url": "https://www.ebi.ac.uk/intact/interactors/id:P02671*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012290", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012290", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014716", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014716", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020837", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020837", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021996", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021996", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:2243", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2243", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "105200", "url": "http://www.omim.org/entry/105200", "database": "MIM", "categories": [ "Other" ] }, { "id": "134820", "url": "http://www.omim.org/entry/134820", "database": "MIM", "categories": [ "Other" ] }, { "id": "202400", "url": "http://www.omim.org/entry/202400", "database": "MIM", "categories": [ "Other" ] }, { "id": "616004", "url": "http://www.omim.org/entry/616004", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_P02671", "url": "https://www.nextprot.org/entry/NX_P02671", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "PRIVEHM", "url": "https://omabrowser.org/oma/group/PRIVEHM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3134470at2759", "url": "http://www.orthodb.org/?query=3134470at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47221:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47221:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1BBR", "url": "https://www.rcsb.org/structure/1BBR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1DM4", "url": "https://www.rcsb.org/structure/1DM4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FPH", "url": "https://www.rcsb.org/structure/1FPH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZA", "url": "https://www.rcsb.org/structure/1FZA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZB", "url": "https://www.rcsb.org/structure/1FZB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZC", "url": "https://www.rcsb.org/structure/1FZC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZD", "url": "https://www.rcsb.org/structure/1FZD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZE", "url": "https://www.rcsb.org/structure/1FZE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZF", "url": "https://www.rcsb.org/structure/1FZF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1FZG", "url": "https://www.rcsb.org/structure/1FZG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1LT9", "url": "https://www.rcsb.org/structure/1LT9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1LTJ", "url": "https://www.rcsb.org/structure/1LTJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1N86", "url": "https://www.rcsb.org/structure/1N86", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1N8E", "url": "https://www.rcsb.org/structure/1N8E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1RE3", "url": "https://www.rcsb.org/structure/1RE3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1RE4", "url": "https://www.rcsb.org/structure/1RE4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1RF0", "url": "https://www.rcsb.org/structure/1RF0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1RF1", "url": "https://www.rcsb.org/structure/1RF1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "1YCP", "url": "https://www.rcsb.org/structure/1YCP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2A45", "url": "https://www.rcsb.org/structure/2A45", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2FFD", "url": "https://www.rcsb.org/structure/2FFD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2H43", "url": "https://www.rcsb.org/structure/2H43", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2HLO", "url": "https://www.rcsb.org/structure/2HLO", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2HOD", "url": "https://www.rcsb.org/structure/2HOD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2HPC", "url": "https://www.rcsb.org/structure/2HPC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2OYH", "url": "https://www.rcsb.org/structure/2OYH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2OYI", "url": "https://www.rcsb.org/structure/2OYI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2Q9I", "url": "https://www.rcsb.org/structure/2Q9I", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2XNX", "url": "https://www.rcsb.org/structure/2XNX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2XNY", "url": "https://www.rcsb.org/structure/2XNY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2Z4E", "url": "https://www.rcsb.org/structure/2Z4E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3AT0", "url": "https://www.rcsb.org/structure/3AT0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3BVH", "url": "https://www.rcsb.org/structure/3BVH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3E1I", "url": "https://www.rcsb.org/structure/3E1I", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3GHG", "url": "https://www.rcsb.org/structure/3GHG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3H32", "url": "https://www.rcsb.org/structure/3H32", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3HUS", "url": "https://www.rcsb.org/structure/3HUS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4F27", "url": "https://www.rcsb.org/structure/4F27", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5CFA", "url": "https://www.rcsb.org/structure/5CFA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00147", "url": "http://pfam.xfam.org/family/PF00147", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08702", "url": "http://pfam.xfam.org/family/PF08702", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12160", "url": "http://pfam.xfam.org/family/PF12160", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "P02671", "url": "https://pharos.nih.gov/targets/P02671", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:000052507", "url": "https://proconsortium.org/app/entry/PR:000052507", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052508", "url": "https://proconsortium.org/app/entry/PR:000052508", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052509", "url": "https://proconsortium.org/app/entry/PR:000052509", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052510", "url": "https://proconsortium.org/app/entry/PR:000052510", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052511", "url": "https://proconsortium.org/app/entry/PR:000052511", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052512", "url": "https://proconsortium.org/app/entry/PR:000052512", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052513", "url": "https://proconsortium.org/app/entry/PR:000052513", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052514", "url": "https://proconsortium.org/app/entry/PR:000052514", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052515", "url": "https://proconsortium.org/app/entry/PR:000052515", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052516", "url": "https://proconsortium.org/app/entry/PR:000052516", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052517", "url": "https://proconsortium.org/app/entry/PR:000052517", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052518", "url": "https://proconsortium.org/app/entry/PR:000052518", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052519", "url": "https://proconsortium.org/app/entry/PR:000052519", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052520", "url": "https://proconsortium.org/app/entry/PR:000052520", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052521", "url": "https://proconsortium.org/app/entry/PR:000052521", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052522", "url": "https://proconsortium.org/app/entry/PR:000052522", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052523", "url": "https://proconsortium.org/app/entry/PR:000052523", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052524", "url": "https://proconsortium.org/app/entry/PR:000052524", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052525", "url": "https://proconsortium.org/app/entry/PR:000052525", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052526", "url": "https://proconsortium.org/app/entry/PR:000052526", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052527", "url": "https://proconsortium.org/app/entry/PR:000052527", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052528", "url": "https://proconsortium.org/app/entry/PR:000052528", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052529", "url": "https://proconsortium.org/app/entry/PR:000052529", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052530", "url": "https://proconsortium.org/app/entry/PR:000052530", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000052531", "url": "https://proconsortium.org/app/entry/PR:000052531", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_P02671", "url": "http://purl.obolibrary.org/obo/PR_P02671", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-354194", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354194", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5602498", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5602498", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5603041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5603041", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6802946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6802955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8957275", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8957275", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P02671", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P02671-1", "url": "https://www.uniprot.org/uniprot/P02671-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P02671-2", "url": "https://www.uniprot.org/uniprot/P02671-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ", "length": 866, "header": "sp|P02671-1|FIBA_HUMAN Isoform 1 of Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2 CANONICAL=P02671-1" }, "isoforms": [ { "isoform_ac": "P02671-1", "url": "", "sequence": { "sequence": "MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ", "length": 866, "header": "sp|P02671-1|FIBA_HUMAN Isoform 1 of Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2 CANONICAL=P02671-1" }, "locus": { "chromosome": "4", "start_pos": 154590687, "end_pos": 154584127, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000651975.2", "url": "https://www.ensembl.org/id/ENST00000651975.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000498441.1", "url": "https://www.ensembl.org/id/ENSP00000498441.1" } ] } }, { "isoform_ac": "P02671-2", "url": "", "sequence": { "sequence": "MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRGIHTSPLGKPSLSP", "length": 644, "header": "sp|P02671-2|FIBA_HUMAN Isoform 2 of Fibrinogen alpha chain OS=Homo sapiens OX=9606 GN=FGA PE=1 SV=2 CANONICAL=P02671-1" }, "locus": { "chromosome": "4", "start_pos": 154590687, "end_pos": 154585497, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000403106.8", "url": "https://www.ensembl.org/id/ENST00000403106.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000385981.3", "url": "https://www.ensembl.org/id/ENSP00000385981.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "DSHSLTTNIMEILR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 101, "start_aa": "Asp", "end_pos": 114, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 107, "start_aa": "Thr", "end_pos": 107, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr107", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "ALTDMPQMR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 250, "start_aa": "Ala", "end_pos": 258, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 252, "start_aa": "Thr", "end_pos": 252, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr252", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "GGSTSYGTGSETESPR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 272, "start_aa": "Gly", "end_pos": 287, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "GGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 272, "start_aa": "Gly", "end_pos": 308, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 283, "start_aa": "Thr", "end_pos": 283, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr283", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G73004SD", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 297, "start_aa": "Ser", "end_pos": 297, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser297", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 315, "start_aa": "Thr", "end_pos": 315, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr315", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 318, "start_aa": "Thr", "end_pos": 318, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr318", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 320, "start_aa": "Thr", "end_pos": 320, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr320", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "reported", "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine O-GalNAcylation", "start_pos": 320, "start_aa": "Thr", "end_pos": 320, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr320", "evidence": [ { "id": "P02671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "id": "23050552", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23050552" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 338, "start_aa": "Ser", "end_pos": 338, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser338", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 341, "start_aa": "Thr", "end_pos": 341, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr341", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 351, "start_aa": "Ser", "end_pos": 351, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser351", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 351, "start_aa": "Ser", "end_pos": 351, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser351", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "reported", "site_seq": "S", "relation": "attached", "comment": "O-linked (GalNAc...) serine O-GalNAcylation", "start_pos": 351, "start_aa": "Ser", "end_pos": 351, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser351", "evidence": [ { "id": "P02671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "id": "23050552", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23050552" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 357, "start_aa": "Thr", "end_pos": 357, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr357", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 359, "start_aa": "Thr", "end_pos": 359, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr359", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 375, "start_aa": "Ser", "end_pos": 375, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser375", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 397, "start_aa": "Ser", "end_pos": 397, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser397", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 499, "start_aa": "Thr", "end_pos": 499, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr499", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 499, "start_aa": "Thr", "end_pos": 499, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr499", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 501, "start_aa": "Ser", "end_pos": 501, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser501", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "HRHPDEAAFFDTASTGK", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 511, "start_aa": "His", "end_pos": 527, "end_aa": "Lys", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G17015OC", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 524, "start_aa": "Ser", "end_pos": 524, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser524", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "26598643", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26598643" } ] }, { "glytoucan_ac": "G17015OC", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 525, "start_aa": "Thr", "end_pos": 525, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr525", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "26598643", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26598643" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 525, "start_aa": "Thr", "end_pos": 525, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr525", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G17015OC", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 528, "start_aa": "Thr", "end_pos": 528, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr528", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" }, { "id": "26598643", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26598643" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 528, "start_aa": "Thr", "end_pos": 528, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr528", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" }, { "id": "26598643", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26598643" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 534, "start_aa": "Ser", "end_pos": 534, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser534", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 546, "start_aa": "Ser", "end_pos": 546, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser546", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 549, "start_aa": "Ser", "end_pos": 549, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser549", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 557, "start_aa": "Thr", "end_pos": 557, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr557", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "ESSSHHPGIAEFPSR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 559, "start_aa": "Glu", "end_pos": 573, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G29068FM", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 562, "start_aa": "Ser", "end_pos": 562, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser562", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 562, "start_aa": "Ser", "end_pos": 562, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser562", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 562, "start_aa": "Ser", "end_pos": 562, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser562", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "QFTSSTSYNR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 582, "start_aa": "Gln", "end_pos": 591, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 586, "start_aa": "Ser", "end_pos": 586, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser586", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "MADEAGSEADHEGTHSTK", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 603, "start_aa": "Met", "end_pos": 620, "end_aa": "Lys", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 616, "start_aa": "Thr", "end_pos": 616, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr616", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 684, "start_aa": "Asn", "end_pos": 684, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn684", "evidence": [ { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "G25418HZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 686, "start_aa": "Asn", "end_pos": 686, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn686", "evidence": [ { "id": "1238", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1238" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G39619TI", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 686, "start_aa": "Asn", "end_pos": 686, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn686", "evidence": [ { "id": "1238", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1238" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G78790NZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 686, "start_aa": "Asn", "end_pos": 686, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn686", "evidence": [ { "id": "1238", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1238" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 686, "start_aa": "Asn", "end_pos": 686, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn686", "evidence": [ { "id": "P02671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19159218" }, { "id": "16335952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16335952" }, { "id": "9689040", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/9689040" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "NNKDSHSLTTNIMEILR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 98, "start_aa": "Asn", "end_pos": 114, "end_aa": "Arg", "evidence": [ { "id": "P02671", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "glytoucan_ac": "G36191CD", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "glytoucan_ac": "G48414YA", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "glytoucan_ac": "G50045TK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "glytoucan_ac": "G75850OP", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "glytoucan_ac": "G84467IZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "glytoucan_ac": "G91365ZQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "", "evidence": [ { "id": "157", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/157" }, { "id": "7107587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/7107587" } ] } ], "phosphorylation": [ { "start_pos": 22, "end_pos": 22, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "16807684", "url": "https://glygen.org/publication/PubMed/16807684" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "12729597", "url": "https://glygen.org/publication/PubMed/12729597" }, { "database": "PubMed", "id": "19117447", "url": "https://glygen.org/publication/PubMed/19117447" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" } ], "site_lbl": "Ser22" }, { "start_pos": 277, "end_pos": 277, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" } ], "site_lbl": "Tyr277" }, { "start_pos": 281, "end_pos": 281, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Ser281" }, { "start_pos": 291, "end_pos": 291, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Ser291" }, { "start_pos": 294, "end_pos": 294, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Ser294" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ], "site_lbl": "Ser356" }, { "start_pos": 364, "end_pos": 364, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by FAM20C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "PubMed", "id": "19562805", "url": "https://glygen.org/publication/PubMed/19562805" }, { "database": "PubMed", "id": "19824718", "url": "https://glygen.org/publication/PubMed/19824718" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" }, { "database": "PubMed", "id": "6719396", "url": "https://glygen.org/publication/PubMed/6719396" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ], "site_lbl": "Ser364" }, { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "19562805", "url": "https://glygen.org/publication/PubMed/19562805" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ], "site_lbl": "Ser365" }, { "start_pos": 412, "end_pos": 412, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" } ], "site_lbl": "Thr412" }, { "start_pos": 451, "end_pos": 451, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Ser451" }, { "start_pos": 45, "end_pos": 45, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by FAM20C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ], "site_lbl": "Ser45" }, { "start_pos": 460, "end_pos": 460, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "81086167", "url": "https://glygen.org/publication/PubMed/81086167" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "6255944", "url": "https://glygen.org/publication/PubMed/6255944" } ], "site_lbl": "Ser460" }, { "start_pos": 501, "end_pos": 501, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Ser501" }, { "start_pos": 505, "end_pos": 505, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Thr505" }, { "start_pos": 50, "end_pos": 50, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "site_lbl": "Ser50" }, { "start_pos": 524, "end_pos": 524, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by FAM20C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ], "site_lbl": "Ser524" }, { "start_pos": 549, "end_pos": 549, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" } ], "site_lbl": "Ser549" }, { "start_pos": 560, "end_pos": 560, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by FAM20C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ], "site_lbl": "Ser560" }, { "start_pos": 56, "end_pos": 56, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by FAM20C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ], "site_lbl": "Ser56" }, { "start_pos": 576, "end_pos": 576, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "92065884", "url": "https://glygen.org/publication/PubMed/92065884" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "1956339", "url": "https://glygen.org/publication/PubMed/1956339" } ], "site_lbl": "Ser576" }, { "start_pos": 577, "end_pos": 577, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "92065884", "url": "https://glygen.org/publication/PubMed/92065884" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "1956339", "url": "https://glygen.org/publication/PubMed/1956339" } ], "site_lbl": "Ser577" }, { "start_pos": 578, "end_pos": 578, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "92065884", "url": "https://glygen.org/publication/PubMed/92065884" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "1956339", "url": "https://glygen.org/publication/PubMed/1956339" } ], "site_lbl": "Ser578" }, { "start_pos": 609, "end_pos": 609, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by FAM20C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ], "site_lbl": "Ser609" }, { "start_pos": 618, "end_pos": 618, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" }, { "database": "PubMed", "id": "92065884", "url": "https://glygen.org/publication/PubMed/92065884" }, { "database": "phospho.ELM", "id": "P02671", "url": "http://phospho.elm.eu.org/byAccession/P02671.html" }, { "database": "PubMed", "id": "1956339", "url": "https://glygen.org/publication/PubMed/1956339" } ], "site_lbl": "Ser618" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.", "evidence": [ { "database": "UniCarbKB", "id": "P02671", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "N-Linked glycosylation and sialylation of the acid-labile subunit. Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Janosi JB, Firth SM, Bond JJ, Baxter RC, Delhanty PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10026136", "url": "https://glygen.org/publication/PubMed/10026136" } ] }, { "title": "Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Yegneswaran S, Smirnov MD, Safa O, Esmon NL, Esmon CT, Johnson AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "10026158", "url": "https://glygen.org/publication/PubMed/10026158" } ] }, { "title": "Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.", "journal": "Biochemistry", "date": "1999", "authors": "Everse SJ, Spraggon G, Veerapandian L, Doolittle RF", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "10074346", "url": "https://glygen.org/publication/PubMed/10074346" } ] }, { "title": "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR 3rd, Conover CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10077652", "url": "https://glygen.org/publication/PubMed/10077652" } ] }, { "title": "Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10097139", "url": "https://glygen.org/publication/PubMed/10097139" } ] }, { "title": "The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Taooka Y, Chen J, Yednock T, Sheppard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10209034", "url": "https://glygen.org/publication/PubMed/10209034" } ] }, { "title": "Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.", "journal": "Current biology : CB", "date": "1999", "authors": "Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "10209122", "url": "https://glygen.org/publication/PubMed/10209122" } ] }, { "title": "The cleavage site specificity of human prostate specific antigen for insulin-like growth factor binding protein-3.", "journal": "FEBS letters", "date": "1999", "authors": "Okabe E, Kajihara J, Usami Y, Hirano K", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10218588", "url": "https://glygen.org/publication/PubMed/10218588" } ] }, { "title": "Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.", "journal": "Nature genetics", "date": "1999", "authors": "Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10319874", "url": "https://glygen.org/publication/PubMed/10319874" } ] }, { "title": "Alpha 2 beta 1 integrin mediates dermal fibroblast attachment to type VII collagen via a 158-amino-acid segment of the NC1 domain.", "journal": "Experimental cell research", "date": "1999", "authors": "Chen M, O'Toole EA, Li YY, Woodley DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10366422", "url": "https://glygen.org/publication/PubMed/10366422" } ] }, { "title": "Characterization of single-nucleotide polymorphisms in coding regions of human genes.", "journal": "Nat. Genet.", "date": "1999", "authors": "Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "10391209", "url": "https://glygen.org/publication/PubMed/10391209" } ] }, { "title": "A stop-codon mutation in the BRI gene associated with familial British dementia.", "journal": "Nature", "date": "1999", "authors": "Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, Ghiso J", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10391242", "url": "https://glygen.org/publication/PubMed/10391242" } ] }, { "title": "Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "10409742", "url": "https://glygen.org/publication/PubMed/10409742" } ] }, { "title": "Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Haggqvist B, Naslund J, Sletten K, Westermark GT, Mucchiano G, Tjernberg LO, Nordstedt C, Engstrom U, Westermark P", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10411933", "url": "https://glygen.org/publication/PubMed/10411933" } ] }, { "title": "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1999", "authors": "Van der Vieren M, Crowe DT, Hoekstra D, Vazeux R, Hoffman PA, Grayson MH, Bochner BS, Gallatin WM, Staunton DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10438935", "url": "https://glygen.org/publication/PubMed/10438935" } ] }, { "title": "Integrin signaling.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Giancotti FG, Ruoslahti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "10446041", "url": "https://glygen.org/publication/PubMed/10446041" } ] }, { "title": "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.", "journal": "Genes & development", "date": "1999", "authors": "Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "10465784", "url": "https://glygen.org/publication/PubMed/10465784" } ] }, { "title": "Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases.", "journal": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society", "date": "1999", "authors": "Gibson TL, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10512690", "url": "https://glygen.org/publication/PubMed/10512690" } ] }, { "title": "Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95.", "journal": "Biochemical and biophysical research communications", "date": "1999", "authors": "Nham SU", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10543983", "url": "https://glygen.org/publication/PubMed/10543983" } ] }, { "title": "Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth.", "journal": "European journal of biochemistry", "date": "1999", "authors": "McLaurin J, Franklin T, Zhang X, Deng J, Fraser PE", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10583407", "url": "https://glygen.org/publication/PubMed/10583407" } ] }, { "title": "The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10593924", "url": "https://glygen.org/publication/PubMed/10593924" } ] }, { "title": "Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways.", "journal": "Thrombosis and haemostasis", "date": "1999", "authors": "Shattil SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10605720", "url": "https://glygen.org/publication/PubMed/10605720" } ] }, { "title": "A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit.", "journal": "Endocrinology", "date": "2000", "authors": "Twigg SM, Kiefer MC, Zapf J, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10614670", "url": "https://glygen.org/publication/PubMed/10614670" } ] }, { "title": "Activation of integrin alpha(V)beta(3) regulates cell adhesion and migration to bone sialoprotein.", "journal": "Experimental cell research", "date": "2000", "authors": "Byzova TV, Kim W, Midura RJ, Plow EF", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10640428", "url": "https://glygen.org/publication/PubMed/10640428" } ] }, { "title": "A regulated interaction between alpha5beta1 integrin and osteopontin.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Barry ST, Ludbrook SB, Murrison E, Horgan CM", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10673366", "url": "https://glygen.org/publication/PubMed/10673366" } ] }, { "title": "Insulin-like growth factor binding protein (IGFBP)-3-bound IGF-I and IGFBP-3-bound IGF-II in growth hormone deficiency.", "journal": "Hormone research", "date": "1999", "authors": "Belgorosky A, Rivarola MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10681634", "url": "https://glygen.org/publication/PubMed/10681634" } ] }, { "title": "Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Nykvist P, Tu H, Ivaska J, Kapyla J, Pihlajaniemi T, Heino J", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10713152", "url": "https://glygen.org/publication/PubMed/10713152" } ] }, { "title": "beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.", "journal": "The Journal of cell biology", "date": "2000", "authors": "DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, Bunnett NW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "10725339", "url": "https://glygen.org/publication/PubMed/10725339" } ] }, { "title": "Crk activation of JNK via C3G and R-Ras.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Mochizuki N, Ohba Y, Kobayashi S, Otsuka N, Graybiel AM, Tanaka S, Matsuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708" } ], "reference": [ { "type": "PubMed", "id": "10777559", "url": "https://glygen.org/publication/PubMed/10777559" } ] }, { "title": "Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6.", "journal": "The Journal of endocrinology", "date": "2000", "authors": "Bond JJ, Meka S, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10810289", "url": "https://glygen.org/publication/PubMed/10810289" } ] }, { "title": "Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Muller J, Cacace AM, Lyons WE, McGill CB, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "10891492", "url": "https://glygen.org/publication/PubMed/10891492" } ] }, { "title": "Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Kirk RI, Sanderson MR, Lerea KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "10896934", "url": "https://glygen.org/publication/PubMed/10896934" } ] }, { "title": "Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease.", "journal": "Archives of biochemistry and biophysics", "date": "2000", "authors": "Qin X, Byun D, Lau KH, Baylink DJ, Mohan S", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10898936", "url": "https://glygen.org/publication/PubMed/10898936" } ] }, { "title": "Effects of IGFBP-2 overexpression in vitro and in vivo.", "journal": "Pediatric nephrology (Berlin, Germany)", "date": "2000", "authors": "Wolf E, Lahm H, Wu M, Wanke R, Hoeflich A", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10912521", "url": "https://glygen.org/publication/PubMed/10912521" } ] }, { "title": "O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis.", "journal": "European journal of biochemistry", "date": "2000", "authors": "Marinaro JA, Neumann GM, Russo VC, Leeding KS, Bach LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10951195", "url": "https://glygen.org/publication/PubMed/10951195" } ] }, { "title": "A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10956649", "url": "https://glygen.org/publication/PubMed/10956649" } ] }, { "title": "Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Cowan KJ, Law DA, Phillips DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "10964917", "url": "https://glygen.org/publication/PubMed/10964917" } ] }, { "title": "Cell contact-dependent activation of alpha3beta1 integrin modulates endothelial cell responses to thrombospondin-1.", "journal": "Molecular biology of the cell", "date": "2000", "authors": "Chandrasekaran L, He CZ, Al-Barazi H, Krutzsch HC, Iruela-Arispe ML, Roberts DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "10982388", "url": "https://glygen.org/publication/PubMed/10982388" } ] }, { "title": "Prostate carcinoma (PC-3) cell proliferation is stimulated by the 22-25-kDa proteolytic fragment (1-160) and inhibited by the 16-kDa fragment (1-95) of recombinant human insulin-like growth factor binding protein-3.", "journal": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society", "date": "1998", "authors": "Angelloz-Nicoud P, Lalou C, Binoux M", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "10990447", "url": "https://glygen.org/publication/PubMed/10990447" } ] }, { "title": "The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2000", "authors": "Kurosawa S, Esmon CT, Stearns-Kurosawa DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "11035113", "url": "https://glygen.org/publication/PubMed/11035113" } ] }, { "title": "Pregnancy-associated plasma protein-A accounts for the insulin-like growth factor (IGF)-binding protein-4 (IGFBP-4) proteolytic activity in human pregnancy serum and enhances the mitogenic activity of IGF by degrading IGFBP-4 in vitro.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2001", "authors": "Byun D, Mohan S, Yoo M, Sexton C, Baylink DJ, Qin X", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11158056", "url": "https://glygen.org/publication/PubMed/11158056" } ] }, { "title": "Interaction of endostatin with integrins implicated in angiogenesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Rehn M, Veikkola T, Kukk-Valdre E, Nakamura H, Ilmonen M, Lombardo C, Pihlajaniemi T, Alitalo K, Vuori K", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "11158588", "url": "https://glygen.org/publication/PubMed/11158588" } ] }, { "title": "Endothelial cell protein C receptor plays an important role in protein C activation in vivo.", "journal": "Blood", "date": "2001", "authors": "Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "11238108", "url": "https://glygen.org/publication/PubMed/11238108" } ] }, { "title": "Ligand-binding characteristics of recombinant amino- and carboxyl-terminal fragments of human insulin-like growth factor-binding protein-3.", "journal": "The Journal of endocrinology", "date": "2001", "authors": "Galanis M, Firth SM, Bond J, Nathanielsz A, Kortt AA, Hudson PJ, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11250653", "url": "https://glygen.org/publication/PubMed/11250653" } ] }, { "title": "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11264294", "url": "https://glygen.org/publication/PubMed/11264294" } ] }, { "title": "Phosphorylation regulates intracellular trafficking of beta-secretase.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "11278841", "url": "https://glygen.org/publication/PubMed/11278841" } ] }, { "title": "Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding.", "journal": "Endocrinology", "date": "2001", "authors": "Firth SM, Clemmons DR, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11316783", "url": "https://glygen.org/publication/PubMed/11316783" } ] }, { "title": "Active Ras induces heterodimerization of cRaf and BRaf.", "journal": "Cancer research", "date": "2001", "authors": "Weber CK, Slupsky JR, Kalmes HA, Rapp UR", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "11325826", "url": "https://glygen.org/publication/PubMed/11325826" } ] }, { "title": "A new human hereditary amyloidosis: the result of a stop-codon mutation in the apolipoprotein AII gene.", "journal": "Genomics", "date": "2001", "authors": "Benson MD, Liepnieks JJ, Yazaki M, Yamashita T, Hamidi Asl K, Guenther B, Kluve-Beckerman B", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "11401442", "url": "https://glygen.org/publication/PubMed/11401442" } ] }, { "title": "Extracellular fibrinogen-binding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding to the alpha-chain.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Palma M, Shannon O, Quezada H C, Berg A, Flock J I", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "11418620", "url": "https://glygen.org/publication/PubMed/11418620" } ] }, { "title": "Codeposition of apolipoprotein A-IV and transthyretin in senile systemic (ATTR) amyloidosis.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Bergstrom J, Murphy C, Eulitz M, Weiss DT, Westermark GT, Solomon A, Westermark P", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "11467836", "url": "https://glygen.org/publication/PubMed/11467836" } ] }, { "title": "Biochemical signals and biological responses elicited by the focal adhesion kinase.", "journal": "Biochimica et biophysica acta", "date": "2001", "authors": "Schaller MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "11476890", "url": "https://glygen.org/publication/PubMed/11476890" } ] }, { "title": "Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2001", "authors": "Smiley ST, King JA, Hancock WW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "11509636", "url": "https://glygen.org/publication/PubMed/11509636" } ] }, { "title": "alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells.", "journal": "Developmental biology", "date": "2001", "authors": "Tiger CF, Fougerousse F, Grundstrom G, Velling T, Gullberg D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "11518510", "url": "https://glygen.org/publication/PubMed/11518510" } ] }, { "title": "Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A.", "journal": "FEBS letters", "date": "2001", "authors": "Laursen LS, Overgaard MT, Soe R, Boldt HB, Sottrup-Jensen L, Giudice LC, Conover CA, Oxvig C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11522292", "url": "https://glygen.org/publication/PubMed/11522292" } ] }, { "title": "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.", "journal": "Nature", "date": "2001", "authors": "Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "11544529", "url": "https://glygen.org/publication/PubMed/11544529" } ] }, { "title": "Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Tulla M, Pentikainen OT, Viitasalo T, Kapyla J, Impola U, Nykvist P, Nissinen L, Johnson MS, Heino J", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "11572855", "url": "https://glygen.org/publication/PubMed/11572855" } ] }, { "title": "Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.", "journal": "Nature medicine", "date": "2001", "authors": "Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "11590439", "url": "https://glygen.org/publication/PubMed/11590439" } ] }, { "title": "Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Schneider MR, Zhou R, Hoeflich A, Krebs O, Schmidt J, Mohan S, Wolf E, Lahm H", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11606061", "url": "https://glygen.org/publication/PubMed/11606061" } ] }, { "title": "Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Nesbitt WS, Kulkarni S, Giuliano S, Goncalves I, Dopheide SM, Yap CL, Harper IS, Salem HH, Jackson SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "11713259", "url": "https://glygen.org/publication/PubMed/11713259" } ] }, { "title": "Surfactant protein A inhibits peptidoglycan-induced tumor necrosis factor-alpha secretion in U937 cells and alveolar macrophages by direct interaction with toll-like receptor 2.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Murakami S, Iwaki D, Mitsuzawa H, Sano H, Takahashi H, Voelker DR, Akino T, Kuroki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "11724772", "url": "https://glygen.org/publication/PubMed/11724772" } ] }, { "title": "IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2002", "authors": "Booth BA, Boes M, Dake BL, Knudtson KL, Bar RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11739083", "url": "https://glygen.org/publication/PubMed/11739083" } ] }, { "title": "Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter?", "journal": "Cancer research", "date": "2001", "authors": "Hoeflich A, Reisinger R, Lahm H, Kiess W, Blum WF, Kolb HJ, Weber MM, Wolf E", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11751371", "url": "https://glygen.org/publication/PubMed/11751371" } ] }, { "title": "Molecular distribution of IGF binding protein-5 in human serum.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2002", "authors": "Baxter RC, Meka S, Firth SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "11788658", "url": "https://glygen.org/publication/PubMed/11788658" } ] }, { "title": "Identification of Sef, a novel modulator of FGF signalling.", "journal": "Nature cell biology", "date": "2002", "authors": "Tsang M, Friesel R, Kudoh T, Dawid IB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "11802164", "url": "https://glygen.org/publication/PubMed/11802164" } ] }, { "title": "Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.", "journal": "Nature cell biology", "date": "2002", "authors": "Furthauer M, Lin W, Ang SL, Thisse B, Thisse C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "11802165", "url": "https://glygen.org/publication/PubMed/11802165" } ] }, { "title": "Binding of serum amyloid P-component (SAP) by amyloid fibrils.", "journal": "Clinical and experimental immunology", "date": "1979", "authors": "Pepys MB, Dyck RF, de Beer FC, Skinner M, Cohen AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "118839", "url": "https://glygen.org/publication/PubMed/118839" } ] }, { "title": "Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "11940607", "url": "https://glygen.org/publication/PubMed/11940607" } ] }, { "title": "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Li S, Strelow A, Fontana EJ, Wesche H", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "11960013", "url": "https://glygen.org/publication/PubMed/11960013" } ] }, { "title": "Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Li Z, Calzada MJ, Sipes JM, Cashel JA, Krutzsch HC, Annis DS, Mosher DF, Roberts DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "11980922", "url": "https://glygen.org/publication/PubMed/11980922" } ] }, { "title": "The structural basis of localization and signaling by the focal adhesion targeting domain.", "journal": "Structure (London, England : 1993)", "date": "2002", "authors": "Arold ST, Hoellerer MK, Noble ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-354194", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354194" } ], "reference": [ { "type": "PubMed", "id": "12005431", "url": "https://glygen.org/publication/PubMed/12005431" } ] }, { "title": "Activation of endothelial cell protease activated receptor 1 by the protein C pathway.", "journal": "Science (New York, N.Y.)", "date": "2002", "authors": "Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "12052963", "url": "https://glygen.org/publication/PubMed/12052963" } ] }, { "title": "Mutations of the BRAF gene in human cancer.", "journal": "Nature", "date": "2002", "authors": "Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "12068308", "url": "https://glygen.org/publication/PubMed/12068308" } ] }, { "title": "Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.", "journal": "Nature", "date": "2002", "authors": "Scaffidi P, Misteli T, Bianchi ME", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "12110890", "url": "https://glygen.org/publication/PubMed/12110890" } ] }, { "title": "Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Ross K, Yang L, Dower S, Volpe F, Guesdon F", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12138165", "url": "https://glygen.org/publication/PubMed/12138165" } ] }, { "title": "Distinct molecular mechanism for initiating TRAF6 signalling.", "journal": "Nature", "date": "2002", "authors": "Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12140561", "url": "https://glygen.org/publication/PubMed/12140561" } ] }, { "title": "Protective role of phospholipid oxidation products in endotoxin-induced tissue damage.", "journal": "Nature", "date": "2002", "authors": "Bochkov VN, Kadl A, Huber J, Gruber F, Binder BR, Leitinger N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "12214235", "url": "https://glygen.org/publication/PubMed/12214235" } ] }, { "title": "Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.", "journal": "The Biochemical journal", "date": "2002", "authors": "Laursen LS, Overgaard MT, Nielsen CG, Boldt HB, Hopmann KH, Conover CA, Sottrup-Jensen L, Giudice LC, Oxvig C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "12241545", "url": "https://glygen.org/publication/PubMed/12241545" } ] }, { "title": "IRAK-4 as the central TIR signaling mediator in innate immunity.", "journal": "Trends in immunology", "date": "2002", "authors": "Suzuki N, Suzuki S, Yeh WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12297423", "url": "https://glygen.org/publication/PubMed/12297423" } ] }, { "title": "IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms.", "journal": "The Journal of endocrinology", "date": "2002", "authors": "Mohan S, Baylink DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "12379487", "url": "https://glygen.org/publication/PubMed/12379487" } ] }, { "title": "Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.", "journal": "Nature", "date": "2002", "authors": "Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12447441", "url": "https://glygen.org/publication/PubMed/12447441" } ] }, { "title": "The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.", "journal": "Nature", "date": "2002", "authors": "Horng T, Barton GM, Flavell RA, Medzhitov R", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12447442", "url": "https://glygen.org/publication/PubMed/12447442" } ] }, { "title": "Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss.", "journal": "The Journal of comparative neurology", "date": "2003", "authors": "Geula C, Bu J, Nagykery N, Scinto LF, Chan J, Joseph J, Parker R, Wu CK", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "12454989", "url": "https://glygen.org/publication/PubMed/12454989" } ] }, { "title": "Cellular actions of the insulin-like growth factor binding proteins.", "journal": "Endocrine reviews", "date": "2002", "authors": "Firth SM, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "12466191", "url": "https://glygen.org/publication/PubMed/12466191" } ] }, { "title": "The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "12473660", "url": "https://glygen.org/publication/PubMed/12473660" } ] }, { "title": "Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.", "journal": "Developmental cell", "date": "2002", "authors": "Teis D, Wunderlich W, Huber LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "12479806", "url": "https://glygen.org/publication/PubMed/12479806" } ] }, { "title": "alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Zhang WM, Kapyla J, Puranen JS, Knight CG, Tiger CF, Pentikainen OT, Johnson MS, Farndale RW, Heino J, Gullberg D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "12496264", "url": "https://glygen.org/publication/PubMed/12496264" } ] }, { "title": "Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C.", "journal": "The Biochemical journal", "date": "2003", "authors": "Giuliano S, Nesbitt WS, Rooney M, Jackson SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708" } ], "reference": [ { "type": "PubMed", "id": "12585966", "url": "https://glygen.org/publication/PubMed/12585966" } ] }, { "title": "Pyogenic bacterial infections in humans with IRAK-4 deficiency.", "journal": "Science (New York, N.Y.)", "date": "2003", "authors": "Picard C, Puel A, Bonnet M, Ku CL, Bustamante J, Yang K, Soudais C, Dupuis S, Feinberg J, Fieschi C, Elbim C, Hitchcock R, Lammas D, Davies G, Al-Ghonaium A, Al-Rayes H, Al-Jumaah S, Al-Hajjar S, Al-Mohsen IZ, Frayha HH, Rucker R, Hawn TR, Aderem A, Tufenkeji H, Haraguchi S, Day NK, Good RA, Gougerot-Pocidalo MA, Ozinsky A, Casanova JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5603041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5603041" } ], "reference": [ { "type": "PubMed", "id": "12637671", "url": "https://glygen.org/publication/PubMed/12637671" } ] }, { "title": "Focal adhesion kinase: the first ten years.", "journal": "Journal of cell science", "date": "2003", "authors": "Parsons JT", "evidence": [ { "database": "Reactome", "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708" } ], "reference": [ { "type": "PubMed", "id": "12640026", "url": "https://glygen.org/publication/PubMed/12640026" } ] }, { "title": "Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, Kalluri R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "12682293", "url": "https://glygen.org/publication/PubMed/12682293" } ] }, { "title": "Isolation and partial characterization of SAA-an amyloid-related protein from human serum.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1976", "authors": "Rosenthal CJ, Franklin EC, Frangione B, Greenspan J", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "1270801", "url": "https://glygen.org/publication/PubMed/1270801" } ] }, { "title": "Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12724322", "url": "https://glygen.org/publication/PubMed/12724322" } ] }, { "title": "Stable isotope phospho-profiling of fibrinogen and fetuin subunits by element mass spectrometry coupled to capillary liquid chromatography.", "journal": "Analytical biochemistry", "date": "2003", "authors": "Wind M, Gosenca D, Kubler D, Lehmann WD", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "12729597", "url": "https://glygen.org/publication/PubMed/12729597" } ] }, { "title": "Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Bax DV, Bernard SE, Lomas A, Morgan A, Humphries J, Shuttleworth CA, Humphries MJ, Kielty CM", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "12807887", "url": "https://glygen.org/publication/PubMed/12807887" } ] }, { "title": "Amino- and carboxyl-terminal fragments of insulin-like growth factor (IGF) binding protein-3 cooperate to bind IGFs with high affinity and inhibit IGF receptor interactions.", "journal": "Endocrinology", "date": "2003", "authors": "Payet LD, Wang XH, Baxter RC, Firth SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "12810533", "url": "https://glygen.org/publication/PubMed/12810533" } ] }, { "title": "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2003", "authors": "Sato M, Sano H, Iwaki D, Kudo K, Konishi M, Takahashi H, Takahashi T, Imaizumi H, Asai Y, Kuroki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "12817025", "url": "https://glygen.org/publication/PubMed/12817025" } ] }, { "title": "Mek2 is dispensable for mouse growth and development.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Belanger LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "12832465", "url": "https://glygen.org/publication/PubMed/12832465" } ] }, { "title": "IGF-binding protein-4: biochemical characteristics and functional consequences.", "journal": "The Journal of endocrinology", "date": "2003", "authors": "Zhou R, Diehl D, Hoeflich A, Lahm H, Wolf E", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "12904166", "url": "https://glygen.org/publication/PubMed/12904166" } ] }, { "title": "Heparin-induced substrate behavior of antithrombin Cambridge II.", "journal": "Blood", "date": "2003", "authors": "Mushunje A, Zhou A, Carrell RW, Huntington JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "12907439", "url": "https://glygen.org/publication/PubMed/12907439" } ] }, { "title": "Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Baxter RC, Bayne ML, Cascieri MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "1370451", "url": "https://glygen.org/publication/PubMed/1370451" } ] }, { "title": "Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1992", "authors": "Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "1383255", "url": "https://glygen.org/publication/PubMed/1383255" } ] }, { "title": "Isolation of dense granules from human platelets.", "journal": "Methods in enzymology", "date": "1992", "authors": "Fukami MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608" } ], "reference": [ { "type": "PubMed", "id": "1435334", "url": "https://glygen.org/publication/PubMed/1435334" } ] }, { "title": "Siah-1 facilitates ubiquitination and degradation of synphilin-1.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "14506261", "url": "https://glygen.org/publication/PubMed/14506261" } ] }, { "title": "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.", "journal": "Biochemistry", "date": "2003", "authors": "He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "14567678", "url": "https://glygen.org/publication/PubMed/14567678" } ] }, { "title": "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits.", "journal": "Biochemistry", "date": "1992", "authors": "Fu Y, Weissbach L, Plant P W, Oddoux C, Cao Y, Liang T J, Roy S N, Redman C M, Grieninger G", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "1457396", "url": "https://glygen.org/publication/PubMed/1457396" } ] }, { "title": "Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P, Li S, Wesche H, Martin MU", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "14625308", "url": "https://glygen.org/publication/PubMed/14625308" } ] }, { "title": "Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.", "journal": "Blood", "date": "2004", "authors": "Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB", "evidence": [ { "database": "Reactome", "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608" } ], "reference": [ { "type": "PubMed", "id": "14630798", "url": "https://glygen.org/publication/PubMed/14630798" } ] }, { "title": "Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.", "journal": "Molecular cell", "date": "2003", "authors": "Ishibe S, Joly D, Zhu X, Cantley LG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "14636584", "url": "https://glygen.org/publication/PubMed/14636584" } ] }, { "title": "Integrin activation.", "journal": "Journal of cell science", "date": "2004", "authors": "Calderwood DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "14754902", "url": "https://glygen.org/publication/PubMed/14754902" } ] }, { "title": "IQGAP1 binds ERK2 and modulates its activity.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Roy M, Li Z, Sacks DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "14970219", "url": "https://glygen.org/publication/PubMed/14970219" } ] }, { "title": "The factor V activation paradox.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Orfeo T, Brufatto N, Nesheim ME, Xu H, Butenas S, Mann KG", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "14982929", "url": "https://glygen.org/publication/PubMed/14982929" } ] }, { "title": "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.", "journal": "Cell", "date": "2004", "authors": "Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "15035987", "url": "https://glygen.org/publication/PubMed/15035987" } ] }, { "title": "Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "15064394", "url": "https://glygen.org/publication/PubMed/15064394" } ] }, { "title": "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "15118098", "url": "https://glygen.org/publication/PubMed/15118098" } ] }, { "title": "The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "2004", "authors": "Payet LD, Firth SM, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "15126567", "url": "https://glygen.org/publication/PubMed/15126567" } ] }, { "title": "Structural basis for integrin alphaIIbbeta3 clustering.", "journal": "Biochemical Society transactions", "date": "2004", "authors": "Li R, Bennett JS, Degrado WF", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "15157149", "url": "https://glygen.org/publication/PubMed/15157149" } ] }, { "title": "Sef is a spatial regulator for Ras/MAP kinase signaling.", "journal": "Developmental cell", "date": "2004", "authors": "Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "15239952", "url": "https://glygen.org/publication/PubMed/15239952" } ] }, { "title": "Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.", "journal": "The Journal of cell biology", "date": "2004", "authors": "Bix G, Fu J, Gonzalez EM, Macro L, Barker A, Campbell S, Zutter MM, Santoro SA, Kim JK, Hook M, Reed CC, Iozzo RV", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15240572", "url": "https://glygen.org/publication/PubMed/15240572" } ] }, { "title": "Sef: a MEK/ERK catcher on the Golgi.", "journal": "Molecular cell", "date": "2004", "authors": "Philips MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "15260967", "url": "https://glygen.org/publication/PubMed/15260967" } ] }, { "title": "The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.", "journal": "Blood", "date": "2004", "authors": "Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK", "evidence": [ { "database": "Reactome", "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608" } ], "reference": [ { "type": "PubMed", "id": "15297306", "url": "https://glygen.org/publication/PubMed/15297306" } ] }, { "title": "C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2004", "authors": "Headey SJ, Keizer DW, Yao S, Brasier G, Kantharidis P, Bach LA, Norton RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "15308688", "url": "https://glygen.org/publication/PubMed/15308688" } ] }, { "title": "Functional assessment of alphaEbeta7/E-cadherin interactions in the steady state postnatal thymus.", "journal": "Clinical & developmental immunology", "date": "2004", "authors": "Prockop SE, Petrie HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15330449", "url": "https://glygen.org/publication/PubMed/15330449" } ] }, { "title": "CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.", "journal": "Nature medicine", "date": "2004", "authors": "Crittenden JR, Bergmeier W, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, Graybiel AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "15334074", "url": "https://glygen.org/publication/PubMed/15334074" } ] }, { "title": "Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.", "journal": "Annals of the rheumatic diseases", "date": "2005", "authors": "Neidhart M, Zaucke F, von Knoch R, Jungel A, Michel BA, Gay RE, Gay S", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15345499", "url": "https://glygen.org/publication/PubMed/15345499" } ] }, { "title": "The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kapyla J, Jaalinoja J, Tulla M, Ylostalo J, Nissinen L, Viitasalo T, Vehvilainen P, Marjomaki V, Nykvist P, Saamanen AM, Farndale RW, Birk DE, Ala-Kokko L, Heino J", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15383545", "url": "https://glygen.org/publication/PubMed/15383545" } ] }, { "title": "Characterization of insulin-like growth factor-free interaction between insulin-like growth factor binding protein 3 and acid labile subunit expressed from Xenopus oocytes.", "journal": "Journal of biochemistry and molecular biology", "date": "2004", "authors": "Choi KY, Kyung YJ, Lee CY, Lee DH", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "15469690", "url": "https://glygen.org/publication/PubMed/15469690" } ] }, { "title": "RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.", "journal": "Developmental cell", "date": "2004", "authors": "Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "15469846", "url": "https://glygen.org/publication/PubMed/15469846" } ] }, { "title": "Role of N- and C-terminal residues of insulin-like growth factor (IGF)-binding protein-3 in regulating IGF complex formation and receptor activation.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Yan X, Forbes BE, McNeil KA, Baxter RC, Firth SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "15485880", "url": "https://glygen.org/publication/PubMed/15485880" } ] }, { "title": "The RAF proteins take centre stage.", "journal": "Nature reviews. Molecular cell biology", "date": "2004", "authors": "Wellbrock C, Karasarides M, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "15520807", "url": "https://glygen.org/publication/PubMed/15520807" } ] }, { "title": "Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding.", "journal": "Journal of molecular endocrinology", "date": "2004", "authors": "Headey SJ, Leeding KS, Norton RS, Bach LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "15525596", "url": "https://glygen.org/publication/PubMed/15525596" } ] }, { "title": "Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.", "journal": "Nature structural & molecular biology", "date": "2004", "authors": "Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "15543157", "url": "https://glygen.org/publication/PubMed/15543157" } ] }, { "title": "MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling.", "journal": "Journal of cellular biochemistry", "date": "2005", "authors": "Sharma C, Vomastek T, Tarcsafalvi A, Catling AD, Schaeffer HJ, Eblen ST, Weber MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "15547943", "url": "https://glygen.org/publication/PubMed/15547943" } ] }, { "title": "Toll-like receptors in innate immunity.", "journal": "International immunology", "date": "2005", "authors": "Takeda K, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "15585605", "url": "https://glygen.org/publication/PubMed/15585605" } ] }, { "title": "The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.", "journal": "J. Biol. Chem.", "date": "1992", "authors": "Martin P D, Robertson W, Turk D, Huber R, Bode W, Edwards B F", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "1560020", "url": "https://glygen.org/publication/PubMed/1560020" } ] }, { "title": "Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.", "journal": "The Journal of clinical investigation", "date": "2005", "authors": "Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA, Nikiforov YE", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "15630448", "url": "https://glygen.org/publication/PubMed/15630448" } ] }, { "title": "Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.", "journal": "Structure (London, England : 1993)", "date": "2005", "authors": "Siwanowicz I, Popowicz GM, Wisniewska M, Huber R, Kuenkele KP, Lang K, Engh RA, Holak TA", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "15642270", "url": "https://glygen.org/publication/PubMed/15642270" } ] }, { "title": "Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.", "journal": "Journal of cell science", "date": "2005", "authors": "Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fassler R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15713743", "url": "https://glygen.org/publication/PubMed/15713743" } ] }, { "title": "VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion.", "journal": "The Journal of experimental medicine", "date": "1992", "authors": "Roldan E, Garcia-Pardo A, Brieva JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "1588291", "url": "https://glygen.org/publication/PubMed/1588291" } ] }, { "title": "Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins.", "journal": "Cancer research", "date": "2005", "authors": "Magnon C, Galaup A, Mullan B, Rouffiac V, Bouquet C, Bidart JM, Griscelli F, Opolon P, Perricaudet M", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "15899827", "url": "https://glygen.org/publication/PubMed/15899827" } ] }, { "title": "Bruton's Tyrosine Kinase is involved in innate and adaptive immunity.", "journal": "Histology and histopathology", "date": "2005", "authors": "Brunner C, Muller B, Wirth T", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "15944945", "url": "https://glygen.org/publication/PubMed/15944945" } ] }, { "title": "Senile seminal vesicle amyloid is derived from semenogelin I.", "journal": "The Journal of laboratory and clinical medicine", "date": "2005", "authors": "Linke RP, Joswig R, Murphy CL, Wang S, Zhou H, Gross U, Rocken C, Westermark P, Weiss DT, Solomon A", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "15962837", "url": "https://glygen.org/publication/PubMed/15962837" } ] }, { "title": "Critical role of the fifth domain of E-cadherin for heterophilic adhesion with alpha E beta 7, but not for homophilic adhesion.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2005", "authors": "Shiraishi K, Tsuzaka K, Yoshimoto K, Kumazawa C, Nozaki K, Abe T, Tsubota K, Takeuchi T", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16002701", "url": "https://glygen.org/publication/PubMed/16002701" } ] }, { "title": "Integrins and Src: dynamic duo of adhesion signaling.", "journal": "Trends in cell biology", "date": "2005", "authors": "Shattil SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "16005629", "url": "https://glygen.org/publication/PubMed/16005629" } ] }, { "title": "A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Rao N, Nguyen S, Ngo K, Fung-Leung WP", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "16024789", "url": "https://glygen.org/publication/PubMed/16024789" } ] }, { "title": "Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy.", "journal": "Biophysical journal", "date": "2005", "authors": "Litvinov RI, Bennett JS, Weisel JW, Shuman H", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "16040750", "url": "https://glygen.org/publication/PubMed/16040750" } ] }, { "title": "Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Chen FH, Thomas AO, Hecht JT, Goldring MB, Lawler J", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16051604", "url": "https://glygen.org/publication/PubMed/16051604" } ] }, { "title": "Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions.", "journal": "Blood", "date": "2005", "authors": "Stork PJ, Dillon TJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "16076873", "url": "https://glygen.org/publication/PubMed/16076873" } ] }, { "title": "PTP-1B is an essential positive regulator of platelet integrin signaling.", "journal": "The Journal of cell biology", "date": "2005", "authors": "Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "16115959", "url": "https://glygen.org/publication/PubMed/16115959" } ] }, { "title": "IQGAP1 is a scaffold for mitogen-activated protein kinase signaling.", "journal": "Molecular and cellular biology", "date": "2005", "authors": "Roy M, Li Z, Sacks DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "16135787", "url": "https://glygen.org/publication/PubMed/16135787" } ] }, { "title": "Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin.", "journal": "The Journal of clinical investigation", "date": "2005", "authors": "Sudhakar A, Nyberg P, Keshamouni VG, Mannam AP, Li J, Sugimoto H, Cosgrove D, Kalluri R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16151532", "url": "https://glygen.org/publication/PubMed/16151532" } ] }, { "title": "Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.", "journal": "Journal of medicinal chemistry", "date": "2005", "authors": "Roehrig S, Straub A, Pohlmann J, Lampe T, Pernerstorfer J, Schlemmer KH, Reinemer P, Perzborn E", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "16161994", "url": "https://glygen.org/publication/PubMed/16161994" } ] }, { "title": "Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, Hyman BT, Paul SM, Nykjaer A, Willnow TE", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "16174740", "url": "https://glygen.org/publication/PubMed/16174740" } ] }, { "title": "Surfactant proteins SP-A and SP-D: structure, function and receptors.", "journal": "Molecular immunology", "date": "2006", "authors": "Kishore U, Greenhough TJ, Waters P, Shrive AK, Ghai R, Kamran MF, Bernal AL, Reid KB, Madan T, Chakraborty T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "16213021", "url": "https://glygen.org/publication/PubMed/16213021" } ] }, { "title": "Integrin alphaDbeta2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties.", "journal": "Blood", "date": "2006", "authors": "Yakubenko VP, Yadav SP, Ugarova TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16239428", "url": "https://glygen.org/publication/PubMed/16239428" } ] }, { "title": "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.", "journal": "Journal of proteome research", "date": "2005", "authors": "Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "16335952", "url": "https://glygen.org/publication/PubMed/16335952" } ] }, { "title": "Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator.", "journal": "The Journal of clinical investigation", "date": "1992", "authors": "Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, Arocha-Pinango CL, Rodriguez S, Nagy H, Perez-Requejo JL, et al.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "1634621", "url": "https://glygen.org/publication/PubMed/1634621" } ] }, { "title": "Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization.", "journal": "Molecular cell", "date": "2005", "authors": "Garnett MJ, Rana S, Paterson H, Barford D, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "16364920", "url": "https://glygen.org/publication/PubMed/16364920" } ] }, { "title": "MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "16439361", "url": "https://glygen.org/publication/PubMed/16439361" } ] }, { "title": "Regulation and role of Raf-1/B-Raf heterodimerization.", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Rushworth LK, Hindley AD, O'Neill E, Kolch W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "16508002", "url": "https://glygen.org/publication/PubMed/16508002" } ] }, { "title": "p130Cas: a versatile scaffold in signaling networks.", "journal": "Trends in cell biology", "date": "2006", "authors": "Defilippi P, Di Stefano P, Cabodi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708" } ], "reference": [ { "type": "PubMed", "id": "16581250", "url": "https://glygen.org/publication/PubMed/16581250" } ] }, { "title": "Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.", "journal": "Oncogene", "date": "2006", "authors": "Brummer T, Martin P, Herzog S, Misawa Y, Daly RJ, Reth M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "16702958", "url": "https://glygen.org/publication/PubMed/16702958" } ] }, { "title": "Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16731529", "url": "https://glygen.org/publication/PubMed/16731529" } ] }, { "title": "Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.", "journal": "Cell", "date": "2006", "authors": "Kagan JC, Medzhitov R", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "16751103", "url": "https://glygen.org/publication/PubMed/16751103" } ] }, { "title": "Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Eble JA, Kassner A, Niland S, Morgelin M, Grifka J, Grassel S", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16754661", "url": "https://glygen.org/publication/PubMed/16754661" } ] }, { "title": "Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response. Importance of supratrimeric oligomerization.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Yamada C, Sano H, Shimizu T, Mitsuzawa H, Nishitani C, Himi T, Kuroki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "16754682", "url": "https://glygen.org/publication/PubMed/16754682" } ] }, { "title": "An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, de Bosch NB, Carvajal Z, Ojeda A, Arocha-Pinango CL, et al.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "dbSNP", "id": "rs121909610", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs121909610" } ], "reference": [ { "type": "PubMed", "id": "1675636", "url": "https://glygen.org/publication/PubMed/1675636" } ] }, { "title": "Rap1 regulation of RIAM and cell adhesion.", "journal": "Methods in enzymology", "date": "2006", "authors": "Lafuente E, Boussiotis VA", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "16757337", "url": "https://glygen.org/publication/PubMed/16757337" } ] }, { "title": "Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K).", "journal": "Nature structural & molecular biology", "date": "2006", "authors": "Kojetin DJ, Venters RA, Kordys DR, Thompson RJ, Kumar R, Cavanagh J", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "16799559", "url": "https://glygen.org/publication/PubMed/16799559" } ] }, { "title": "Phosphoproteomic analysis of the human pituitary.", "journal": "Pituitary", "date": "2006", "authors": "Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "reference": [ { "type": "PubMed", "id": "16807684", "url": "https://glygen.org/publication/PubMed/16807684" } ] }, { "title": "Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide.", "journal": "Biochemistry", "date": "2006", "authors": "Ohya M, Nishitani C, Sano H, Yamada C, Mitsuzawa H, Shimizu T, Saito T, Smith K, Crouch E, Kuroki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "16834340", "url": "https://glygen.org/publication/PubMed/16834340" } ] }, { "title": "The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.", "journal": "British journal of haematology", "date": "2006", "authors": "Flood VH, Al-Mondhiry HA, Farrell DH", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "16846481", "url": "https://glygen.org/publication/PubMed/16846481" } ] }, { "title": "The extracellular release of HMGB1 during apoptotic cell death.", "journal": "American journal of physiology. Cell physiology", "date": "2006", "authors": "Bell CW, Jiang W, Reich CF 3rd, Pisetsky DS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "16855214", "url": "https://glygen.org/publication/PubMed/16855214" } ] }, { "title": "HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.", "journal": "Shock (Augusta, Ga.)", "date": "2006", "authors": "Yu M, Wang H, Ding A, Golenbock DT, Latz E, Czura CJ, Fenton MJ, Tracey KJ, Yang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "16878026", "url": "https://glygen.org/publication/PubMed/16878026" } ] }, { "title": "Distinct functions for ERKs?", "journal": "Journal of biology", "date": "2006", "authors": "Lloyd AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "16879721", "url": "https://glygen.org/publication/PubMed/16879721" } ] }, { "title": "Integrin-regulated FAK-Src signaling in normal and cancer cells.", "journal": "Current opinion in cell biology", "date": "2006", "authors": "Mitra SK, Schlaepfer DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "16919435", "url": "https://glygen.org/publication/PubMed/16919435" } ] }, { "title": "The synergy site of fibronectin is required for strong interaction with the platelet integrin alphaIIbbeta3.", "journal": "Annals of biomedical engineering", "date": "2006", "authors": "Chada D, Mather T, Nollert MU", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "16933105", "url": "https://glygen.org/publication/PubMed/16933105" } ] }, { "title": "In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.", "journal": "Cancer research", "date": "2006", "authors": "Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA, Bastian BC, Springer C, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "17018604", "url": "https://glygen.org/publication/PubMed/17018604" } ] }, { "title": "The role of insulin-like growth factor binding proteins.", "journal": "Neuroendocrinology", "date": "2006", "authors": "Holly J, Perks C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "17047378", "url": "https://glygen.org/publication/PubMed/17047378" } ] }, { "title": "Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Cheng H, Addona T, Keshishian H, Dahlstrand E, Lu C, Dorsch M, Li Z, Wang A, Ocain TD, Li P, Parsons TF, Jaffee B, Xu Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "17141195", "url": "https://glygen.org/publication/PubMed/17141195" } ] }, { "title": "Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.", "journal": "Cancer research", "date": "2006", "authors": "King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "17145850", "url": "https://glygen.org/publication/PubMed/17145850" } ] }, { "title": "p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M, Offterdinger M, Villunger A, Geley S, Bohn G, Klein C, Hess MW, Huber LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "17178906", "url": "https://glygen.org/publication/PubMed/17178906" } ] }, { "title": "Structural basis of integrin activation by talin.", "journal": "Cell", "date": "2007", "authors": "Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "17218263", "url": "https://glygen.org/publication/PubMed/17218263" } ] }, { "title": "CSK: a protein-tyrosine kinase involved in regulation of src family kinases.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "1722201", "url": "https://glygen.org/publication/PubMed/1722201" } ] }, { "title": "Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A.", "journal": "Biochemistry", "date": "2007", "authors": "Gyrup C, Oxvig C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "17249697", "url": "https://glygen.org/publication/PubMed/17249697" } ] }, { "title": "Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5.", "journal": "Molecular endocrinology (Baltimore, Md.)", "date": "2007", "authors": "Laursen LS, Kjaer-Sorensen K, Andersen MH, Oxvig C", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "17312271", "url": "https://glygen.org/publication/PubMed/17312271" } ] }, { "title": "Critical residues of alphaX I-domain recognizing fibrinogen central domain.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Lee JH, Choi J, Nham SU", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "17339034", "url": "https://glygen.org/publication/PubMed/17339034" } ] }, { "title": "A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1.", "journal": "The Biochemical journal", "date": "2007", "authors": "Costantini C, Ko MH, Jonas MC, Puglielli L", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "17425515", "url": "https://glygen.org/publication/PubMed/17425515" } ] }, { "title": "Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.", "journal": "The Journal of experimental medicine", "date": "2007", "authors": "Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "17485511", "url": "https://glygen.org/publication/PubMed/17485511" } ] }, { "title": "KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.", "journal": "Oncogene", "date": "2007", "authors": "Claperon A, Therrien M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "17496912", "url": "https://glygen.org/publication/PubMed/17496912" } ] }, { "title": "IQGAP1 modulates activation of B-Raf.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Ren JG, Li Z, Sacks DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "17563371", "url": "https://glygen.org/publication/PubMed/17563371" } ] }, { "title": "Germline gain-of-function mutations in RAF1 cause Noonan syndrome.", "journal": "Nature genetics", "date": "2007", "authors": "Razzaque MA, Nishizawa T, Komoike Y, Yagi H, Furutani M, Amo R, Kamisago M, Momma K, Katayama H, Nakagawa M, Fujiwara Y, Matsushima M, Mizuno K, Tokuyama M, Hirota H, Muneuchi J, Higashinakagawa T, Matsuoka R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "17603482", "url": "https://glygen.org/publication/PubMed/17603482" } ] }, { "title": "Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.", "journal": "Nature genetics", "date": "2007", "authors": "Pandit B, Sarkozy A, Pennacchio LA, Carta C, Oishi K, Martinelli S, Pogna EA, Schackwitz W, Ustaszewska A, Landstrom A, Bos JM, Ommen SR, Esposito G, Lepri F, Faul C, Mundel P, Lopez Siguero JP, Tenconi R, Selicorni A, Rossi C, Mazzanti L, Torrente I, Marino B, Digilio MC, Zampino G, Ackerman MJ, Dallapiccola B, Tartaglia M, Gelb BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "17603483", "url": "https://glygen.org/publication/PubMed/17603483" } ] }, { "title": "Platelet integrins and immunoreceptors.", "journal": "Immunological reviews", "date": "2007", "authors": "Kasirer-Friede A, Kahn ML, Shattil SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "17624957", "url": "https://glygen.org/publication/PubMed/17624957" } ] }, { "title": "Activated protein C.", "journal": "Journal of thrombosis and haemostasis : JTH", "date": "2007", "authors": "Griffin JH, Fernandez JA, Gale AJ, Mosnier LO", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "17635713", "url": "https://glygen.org/publication/PubMed/17635713" } ] }, { "title": "A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.", "journal": "PloS one", "date": "2007", "authors": "Nunez Miguel R, Wong J, Westoll JF, Brooks HJ, O'Neill LA, Gay NJ, Bryant CE, Monie TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "17726518", "url": "https://glygen.org/publication/PubMed/17726518" } ] }, { "title": "Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.", "journal": "Nature medicine", "date": "2007", "authors": "Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "17767165", "url": "https://glygen.org/publication/PubMed/17767165" } ] }, { "title": "IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Keating SE, Maloney GM, Moran EM, Bowie AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "17878161", "url": "https://glygen.org/publication/PubMed/17878161" } ] }, { "title": "TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2007", "authors": "Hoarau C, Gerard B, Lescanne E, Henry D, Francois S, Lacapere JJ, El Benna J, Dang PM, Grandchamp B, Lebranchu Y, Gougerot-Pocidalo MA, Elbim C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5603041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5603041" } ], "reference": [ { "type": "PubMed", "id": "17878374", "url": "https://glygen.org/publication/PubMed/17878374" } ] }, { "title": "IRAK1: a critical signaling mediator of innate immunity.", "journal": "Cellular signalling", "date": "2008", "authors": "Gottipati S, Rao NL, Fung-Leung WP", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "17890055", "url": "https://glygen.org/publication/PubMed/17890055" } ] }, { "title": "Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.", "journal": "The Journal of experimental medicine", "date": "2007", "authors": "Ku CL, von Bernuth H, Picard C, Zhang SY, Chang HH, Yang K, Chrabieh M, Issekutz AC, Cunningham CK, Gallin J, Holland SM, Roifman C, Ehl S, Smart J, Tang M, Barrat FJ, Levy O, McDonald D, Day-Good NK, Miller R, Takada H, Hara T, Al-Hajjar S, Al-Ghonaium A, Speert D, Sanlaville D, Li X, Geissmann F, Vivier E, Marodi L, Garty BZ, Chapel H, Rodriguez-Gallego C, Bossuyt X, Abel L, Puel A, Casanova JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5603041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5603041" } ], "reference": [ { "type": "PubMed", "id": "17893200", "url": "https://glygen.org/publication/PubMed/17893200" } ] }, { "title": "Involvement of alpha(v)beta3 integrins in osteoclast function.", "journal": "Journal of bone and mineral metabolism", "date": "2007", "authors": "Nakamura I, Duong LT, Rodan SB, Rodan GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "17968485", "url": "https://glygen.org/publication/PubMed/17968485" } ] }, { "title": "Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding.", "journal": "Biochemistry", "date": "2007", "authors": "Kuang Z, Yao S, McNeil KA, Thompson JA, Bach LA, Forbes BE, Wallace JC, Norton RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "17985932", "url": "https://glygen.org/publication/PubMed/17985932" } ] }, { "title": "Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.", "journal": "Human molecular genetics", "date": "2008", "authors": "Lee JT, Wheeler TC, Li L, Chin LS", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "18065497", "url": "https://glygen.org/publication/PubMed/18065497" } ] }, { "title": "Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Piao W, Song C, Chen H, Wahl LM, Fitzgerald KA, O'Neill LA, Medvedev AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "18070880", "url": "https://glygen.org/publication/PubMed/18070880" } ] }, { "title": "Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "18070888", "url": "https://glygen.org/publication/PubMed/18070888" } ] }, { "title": "TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB.", "journal": "Journal of leukocyte biology", "date": "2008", "authors": "Muroi M, Tanamoto K", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "18070982", "url": "https://glygen.org/publication/PubMed/18070982" } ] }, { "title": "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.", "journal": "Cell", "date": "2007", "authors": "Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "18083107", "url": "https://glygen.org/publication/PubMed/18083107" } ] }, { "title": "Phosphoproteome of resting human platelets.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" } ] }, { "title": "Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KS, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim SH, Schlessinger J, Zhang KY, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "18287029", "url": "https://glygen.org/publication/PubMed/18287029" } ] }, { "title": "High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2008", "authors": "Youn JH, Oh YJ, Kim ES, Choi JE, Shin JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "18354232", "url": "https://glygen.org/publication/PubMed/18354232" } ] }, { "title": "Atrial amyloid deposits in the failing human heart display both atrial and brain natriuretic peptide-like immunoreactivity.", "journal": "The Journal of pathology", "date": "1991", "authors": "Pucci A, Wharton J, Arbustini E, Grasso M, Diegoli M, Needleman P, Vigano M, Polak JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "1837051", "url": "https://glygen.org/publication/PubMed/1837051" } ] }, { "title": "Talin at a glance.", "journal": "Journal of cell science", "date": "2008", "authors": "Critchley DR, Gingras AR", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "18434644", "url": "https://glygen.org/publication/PubMed/18434644" } ] }, { "title": "Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.", "journal": "Nature immunology", "date": "2008", "authors": "Kawagoe T, Sato S, Matsushita K, Kato H, Matsui K, Kumagai Y, Saitoh T, Kawai T, Takeuchi O, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "18438411", "url": "https://glygen.org/publication/PubMed/18438411" } ] }, { "title": "Leukocyte chemotactic factor 2: A novel renal amyloid protein.", "journal": "Kidney international", "date": "2008", "authors": "Benson MD, James S, Scott K, Liepnieks JJ, Kluve-Beckerman B", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "18449172", "url": "https://glygen.org/publication/PubMed/18449172" } ] }, { "title": "Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles.", "journal": "Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis", "date": "2008", "authors": "Murphy CL, Kestler DP, Foster JS, Wang S, Macy SD, Kennel SJ, Carlson ER, Hudson J, Weiss DT, Solomon A", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "18484335", "url": "https://glygen.org/publication/PubMed/18484335" } ] }, { "title": "Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin.", "journal": "The Journal of clinical investigation", "date": "1991", "authors": "Maury CP", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "1849145", "url": "https://glygen.org/publication/PubMed/1849145" } ] }, { "title": "Oxidized phospholipid inhibition of toll-like receptor (TLR) signaling is restricted to TLR2 and TLR4: roles for CD14, LPS-binding protein, and MD2 as targets for specificity of inhibition.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Erridge C, Kennedy S, Spickett CM, Webb DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "18559343", "url": "https://glygen.org/publication/PubMed/18559343" } ] }, { "title": "Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.", "journal": "Cancer research", "date": "2008", "authors": "Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman J", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "18559533", "url": "https://glygen.org/publication/PubMed/18559533" } ] }, { "title": "The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells.", "journal": "The international journal of biochemistry & cell biology", "date": "2008", "authors": "Ramos JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "18562239", "url": "https://glygen.org/publication/PubMed/18562239" } ] }, { "title": "Pyogenic bacterial infections in humans with MyD88 deficiency.", "journal": "Science (New York, N.Y.)", "date": "2008", "authors": "von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5602498", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5602498" } ], "reference": [ { "type": "PubMed", "id": "18669862", "url": "https://glygen.org/publication/PubMed/18669862" } ] }, { "title": "Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation.", "journal": "Cell", "date": "2008", "authors": "Suzuki K, Verma IM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974" } ], "reference": [ { "type": "PubMed", "id": "18692471", "url": "https://glygen.org/publication/PubMed/18692471" } ] }, { "title": "Assembly of oligomeric death domain complexes during Toll receptor signaling.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Moncrieffe MC, Grossmann JG, Gay NJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "18829464", "url": "https://glygen.org/publication/PubMed/18829464" } ] }, { "title": "Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.", "journal": "Cancer research", "date": "2008", "authors": "Jones DT, Kocialkowski S, Liu L, Pearson DM, Backlund LM, Ichimura K, Collins VP", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "18974108", "url": "https://glygen.org/publication/PubMed/18974108" } ] }, { "title": "Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Yamazoe M, Nishitani C, Takahashi M, Katoh T, Ariki S, Shimizu T, Mitsuzawa H, Sawada K, Voelker DR, Takahashi H, Kuroki Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "18990700", "url": "https://glygen.org/publication/PubMed/18990700" } ] }, { "title": "Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Ko MH, Puglielli L", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "19011241", "url": "https://glygen.org/publication/PubMed/19011241" } ] }, { "title": "Protein scaffolds in MAP kinase signalling.", "journal": "Cellular signalling", "date": "2009", "authors": "Brown MD, Sacks DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "19091303", "url": "https://glygen.org/publication/PubMed/19091303" } ] }, { "title": "Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2009", "authors": "von Schlieffen E, Oskolkova OV, Schabbauer G, Gruber F, Bluml S, Genest M, Kadl A, Marsik C, Knapp S, Chow J, Leitinger N, Binder BR, Bochkov VN", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "19112167", "url": "https://glygen.org/publication/PubMed/19112167" } ] }, { "title": "Profiling of endogenous serum phosphorylated peptides by titanium (IV) immobilized mesoporous silica particles enrichment and MALDI-TOFMS detection.", "journal": "Analytical chemistry", "date": "2009", "authors": "Hu L, Zhou H, Li Y, Sun S, Guo L, Ye M, Tian X, Gu J, Yang S, Zou H", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "19117447", "url": "https://glygen.org/publication/PubMed/19117447" } ] }, { "title": "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.", "journal": "Journal of proteome research", "date": "2009", "authors": "Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "title": "MHC molecules and microbial antigen processing in phagosomes.", "journal": "Current opinion in immunology", "date": "2009", "authors": "Ramachandra L, Simmons D, Harding CV", "evidence": [ { "database": "Reactome", "id": "R-HSA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974" } ], "reference": [ { "type": "PubMed", "id": "19217269", "url": "https://glygen.org/publication/PubMed/19217269" } ] }, { "title": "A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.", "journal": "Nature structural & molecular biology", "date": "2009", "authors": "Catalanotti F, Reyes G, Jesenberger V, Galabova-Kovacs G, de Matos Simoes R, Carugo O, Baccarini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "19219045", "url": "https://glygen.org/publication/PubMed/19219045" } ] }, { "title": "Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Wan Y, Xiao H, Affolter J, Kim TW, Bulek K, Chaudhuri S, Carlson D, Hamilton T, Mazumder B, Stark GR, Thomas J, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "19224918", "url": "https://glygen.org/publication/PubMed/19224918" } ] }, { "title": "Total ERK1/2 activity regulates cell proliferation.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2009", "authors": "Lefloch R, Pouyssegur J, Lenormand P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "19242111", "url": "https://glygen.org/publication/PubMed/19242111" } ] }, { "title": "ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2009", "authors": "Casar B, Pinto A, Crespo P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "19279408", "url": "https://glygen.org/publication/PubMed/19279408" } ] }, { "title": "Crystal structure of human fibrinogen.", "journal": "Biochemistry", "date": "2009", "authors": "Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle RF", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "19296670", "url": "https://glygen.org/publication/PubMed/19296670" } ] }, { "title": "Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenz amide, a highly potent, selective, and orally efficacious factor Xa inhibitor.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2009", "authors": "Zhang P, Huang W, Wang L, Bao L, Jia ZJ, Bauer SM, Goldman EA, Probst GD, Song Y, Su T, Fan J, Wu Y, Li W, Woolfrey J, Sinha U, Wong PW, Edwards ST, Arfsten AE, Clizbe LA, Kanter J, Pandey A, Park G, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "19297154", "url": "https://glygen.org/publication/PubMed/19297154" } ] }, { "title": "The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation.", "journal": "Current opinion in genetics & development", "date": "2009", "authors": "Tidyman WE, Rauen KA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "19467855", "url": "https://glygen.org/publication/PubMed/19467855" } ] }, { "title": "Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity.", "journal": "Journal of innate immunity", "date": "2009", "authors": "Towb P, Sun H, Wasserman SA", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "19498957", "url": "https://glygen.org/publication/PubMed/19498957" } ] }, { "title": "Molecular interplay between endostatin, integrins, and heparan sulfate.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Faye C, Moreau C, Chautard E, Jetne R, Fukai N, Ruggiero F, Humphries MJ, Olsen BR, Ricard-Blum S", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "19502598", "url": "https://glygen.org/publication/PubMed/19502598" } ] }, { "title": "Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5602498", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5602498" } ], "reference": [ { "type": "PubMed", "id": "19506249", "url": "https://glygen.org/publication/PubMed/19506249" } ] }, { "title": "A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "19509286", "url": "https://glygen.org/publication/PubMed/19509286" } ] }, { "title": "Quantitative analysis of phosphopeptides in search of the disease biomarker from the hepatocellular carcinoma specimen.", "journal": "Proteomics", "date": "2009", "authors": "Lee HJ, Na K, Kwon MS, Kim H, Kim KS, Paik YK", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "19562805", "url": "https://glygen.org/publication/PubMed/19562805" } ] }, { "title": "Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations.", "journal": "Methods in enzymology", "date": "1991", "authors": "Pearson RB, Kemp BE", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "reference": [ { "type": "PubMed", "id": "1956339", "url": "https://glygen.org/publication/PubMed/1956339" } ] }, { "title": "An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Motshwene PG, Moncrieffe MC, Grossmann JG, Kao C, Ayaluru M, Sandercock AM, Robinson CV, Latz E, Gay NJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "19592493", "url": "https://glygen.org/publication/PubMed/19592493" } ] }, { "title": "MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "19592497", "url": "https://glygen.org/publication/PubMed/19592497" } ] }, { "title": "Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry.", "journal": "Biochemistry", "date": "2009", "authors": "Hobbs CA, Deterding LJ, Perera L, Bobay BG, Thompson RJ, Darden TA, Cavanagh J, Tomer KB", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "19658395", "url": "https://glygen.org/publication/PubMed/19658395" } ] }, { "title": "Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Ono M, Matsubara J, Honda K, Sakuma T, Hashiguchi T, Nose H, Nakamori S, Okusaka T, Kosuge T, Sata N, Nagai H, Ioka T, Tanaka S, Tsuchida A, Aoki T, Shimahara M, Yasunami Y, Itoi T, Moriyasu F, Negishi A, Kuwabara H, Shoji A, Hirohashi S, Yamada T", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "19696023", "url": "https://glygen.org/publication/PubMed/19696023" } ] }, { "title": "An initial characterization of the serum phosphoproteome.", "journal": "Journal of proteome research", "date": "2009", "authors": "Zhou W, Ross MM, Tessitore A, Ornstein D, Vanmeter A, Liotta LA, Petricoin EF 3rd", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "19824718", "url": "https://glygen.org/publication/PubMed/19824718" } ] }, { "title": "gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2009", "authors": "Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "19828817", "url": "https://glygen.org/publication/PubMed/19828817" } ] }, { "title": "Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Ritt DA, Monson DM, Specht SI, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "19933846", "url": "https://glygen.org/publication/PubMed/19933846" } ] }, { "title": "Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin.", "journal": "Molecular and cellular biochemistry", "date": "2010", "authors": "Rock MJ, Holden P, Horton WA, Cohn DH", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "20033473", "url": "https://glygen.org/publication/PubMed/20033473" } ] }, { "title": "CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.", "journal": "Nature immunology", "date": "2010", "authors": "Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "20037584", "url": "https://glygen.org/publication/PubMed/20037584" } ] }, { "title": "Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.", "journal": "Human mutation", "date": "2010", "authors": "Kobayashi T, Aoki Y, Niihori T, Cave H, Verloes A, Okamoto N, Kawame H, Fujiwara I, Takada F, Ohata T, Sakazume S, Ando T, Nakagawa N, Lapunzina P, Meneses AG, Gillessen-Kaesbach G, Wieczorek D, Kurosawa K, Mizuno S, Ohashi H, David A, Philip N, Guliyeva A, Narumi Y, Kure S, Tsuchiya S, Matsubara Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "20052757", "url": "https://glygen.org/publication/PubMed/20052757" } ] }, { "title": "Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer.", "journal": "Analytical chemistry", "date": "2010", "authors": "Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "Thrombospondin-induced adhesion of human platelets.", "journal": "The Journal of clinical investigation", "date": "1991", "authors": "Tuszynski GP, Kowalska MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "2010551", "url": "https://glygen.org/publication/PubMed/2010551" } ] }, { "title": "RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.", "journal": "Nature", "date": "2010", "authors": "Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "20130576", "url": "https://glygen.org/publication/PubMed/20130576" } ] }, { "title": "Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.", "journal": "Cell", "date": "2010", "authors": "Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis-Filho JS, Springer CJ, Pritchard C, Marais R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "20141835", "url": "https://glygen.org/publication/PubMed/20141835" } ] }, { "title": "RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.", "journal": "Nature", "date": "2010", "authors": "Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "20179705", "url": "https://glygen.org/publication/PubMed/20179705" } ] }, { "title": "The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells.", "journal": "Nature medicine", "date": "2010", "authors": "Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, Klenner L, Kuhn A, Foell D, Sorokin L, Luger TA, Roth J, Beissert S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "20473308", "url": "https://glygen.org/publication/PubMed/20473308" } ] }, { "title": "Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.", "journal": "Nature", "date": "2010", "authors": "Lin SC, Lo YC, Wu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "20485341", "url": "https://glygen.org/publication/PubMed/20485341" } ] }, { "title": "Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.", "journal": "Nature medicine", "date": "2010", "authors": "Palanisamy N, Ateeq B, Kalyana-Sundaram S, Pflueger D, Ramnarayanan K, Shankar S, Han B, Cao Q, Cao X, Suleman K, Kumar-Sinha C, Dhanasekaran SM, Chen YB, Esgueva R, Banerjee S, LaFargue CJ, Siddiqui J, Demichelis F, Moeller P, Bismar TA, Kuefer R, Fullen DR, Johnson TM, Greenson JK, Giordano TJ, Tan P, Tomlins SA, Varambally S, Rubin MA, Maher CA, Chinnaiyan AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "20526349", "url": "https://glygen.org/publication/PubMed/20526349" } ] }, { "title": "ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.", "journal": "The EMBO journal", "date": "2010", "authors": "Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "20676056", "url": "https://glygen.org/publication/PubMed/20676056" } ] }, { "title": "Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine.", "journal": "Blood", "date": "1991", "authors": "Yoshida N, Okuma M, Hirata H, Matsuda M, Yamazumi K, Asakura S", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "2070049", "url": "https://glygen.org/publication/PubMed/2070049" } ] }, { "title": "Lumican inhibits cell migration through alpha2beta1 integrin.", "journal": "Experimental cell research", "date": "2010", "authors": "Zeltz C, Brezillon S, Kapyla J, Eble JA, Bobichon H, Terryn C, Perreau C, Franz CM, Heino J, Maquart FX, Wegrowski Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "20705068", "url": "https://glygen.org/publication/PubMed/20705068" } ] }, { "title": "Heparan sulfate proteoglycans in amyloidosis.", "journal": "Progress in molecular biology and translational science", "date": "2010", "authors": "Zhang X, Li JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "20807650", "url": "https://glygen.org/publication/PubMed/20807650" } ] }, { "title": "Inhibition of mutated, activated BRAF in metastatic melanoma.", "journal": "The New England journal of medicine", "date": "2010", "authors": "Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "20818844", "url": "https://glygen.org/publication/PubMed/20818844" } ] }, { "title": "Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.", "journal": "Science signaling", "date": "2010", "authors": "Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, Bastiaens PI", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "20858867", "url": "https://glygen.org/publication/PubMed/20858867" } ] }, { "title": "Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "George J, Motshwene PG, Wang H, Kubarenko AV, Rautanen A, Mills TC, Hill AV, Gay NJ, Weber AN", "evidence": [ { "database": "Reactome", "id": "R-HSA-5602498", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5602498" } ], "reference": [ { "type": "PubMed", "id": "20966070", "url": "https://glygen.org/publication/PubMed/20966070" } ] }, { "title": "Nucleotide sequences of the three genes coding for human fibrinogen.", "journal": "Adv. Exp. Med. Biol.", "date": "1990", "authors": "Chung D W, Harris J E, Davie E W", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "2102623", "url": "https://glygen.org/publication/PubMed/2102623" } ] }, { "title": "Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.", "journal": "Nature", "date": "2010", "authors": "Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "21107323", "url": "https://glygen.org/publication/PubMed/21107323" } ] }, { "title": "Immunoglobulin heavy-chain-associated amyloidosis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1990", "authors": "Eulitz M, Weiss DT, Solomon A", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "2118650", "url": "https://glygen.org/publication/PubMed/2118650" } ] }, { "title": "Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma.", "journal": "Acta neuropathologica", "date": "2011", "authors": "Cin H, Meyer C, Herr R, Janzarik WG, Lambert S, Jones DT, Jacob K, Benner A, Witt H, Remke M, Bender S, Falkenstein F, Van Anh TN, Olbrich H, von Deimling A, Pekrun A, Kulozik AE, Gnekow A, Scheurlen W, Witt O, Omran H, Jabado N, Collins VP, Brummer T, Marschalek R, Lichter P, Korshunov A, Pfister SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "21424530", "url": "https://glygen.org/publication/PubMed/21424530" } ] }, { "title": "A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.", "journal": "The Journal of biological chemistry", "date": "1990", "authors": "Kirschbaum NE, Budzynski AZ", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "2143188", "url": "https://glygen.org/publication/PubMed/2143188" } ] }, { "title": "c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.", "journal": "Cancer cell", "date": "2011", "authors": "Blasco RB, Francoz S, Santamaria D, Canamero M, Dubus P, Charron J, Baccarini M, Barbacid M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "21514245", "url": "https://glygen.org/publication/PubMed/21514245" } ] }, { "title": "Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Flannery SM, Keating SE, Szymak J, Bowie AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "21606490", "url": "https://glygen.org/publication/PubMed/21606490" } ] }, { "title": "Improved survival with vemurafenib in melanoma with BRAF V600E mutation.", "journal": "The New England journal of medicine", "date": "2011", "authors": "Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "21639808", "url": "https://glygen.org/publication/PubMed/21639808" } ] }, { "title": "Raf family kinases: old dogs have learned new tricks.", "journal": "Genes & cancer", "date": "2011", "authors": "Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "21779496", "url": "https://glygen.org/publication/PubMed/21779496" } ] }, { "title": "Spectrum of mutations in Noonan syndrome and their correlation with phenotypes.", "journal": "The Journal of pediatrics", "date": "2011", "authors": "Lee BH, Kim JM, Jin HY, Kim GH, Choi JH, Yoo HW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "21784453", "url": "https://glygen.org/publication/PubMed/21784453" } ] }, { "title": "High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.", "journal": "Arthritis research & therapy", "date": "2011", "authors": "Wahamaa H, Schierbeck H, Hreggvidsdottir HS, Palmblad K, Aveberger AC, Andersson U, Harris HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "21871094", "url": "https://glygen.org/publication/PubMed/21871094" } ] }, { "title": "Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1990", "authors": "Westermark P, Engstrom U, Johnson KH, Westermark GT, Betsholtz C", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "2195544", "url": "https://glygen.org/publication/PubMed/2195544" } ] }, { "title": "RAS oncogenes: weaving a tumorigenic web.", "journal": "Nature reviews. Cancer", "date": "2011", "authors": "Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "21993244", "url": "https://glygen.org/publication/PubMed/21993244" } ] }, { "title": "C-Raf is required for the initiation of lung cancer by K-Ras(G12D).", "journal": "Cancer discovery", "date": "2011", "authors": "Karreth FA, Frese KK, DeNicola GM, Baccarini M, Tuveson DA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "22043453", "url": "https://glygen.org/publication/PubMed/22043453" } ] }, { "title": "alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Rott R, Szargel R, Haskin J, Bandopadhyay R, Lees AJ, Shani V, Engelender S", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "22065755", "url": "https://glygen.org/publication/PubMed/22065755" } ] }, { "title": "RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).", "journal": "Nature", "date": "2011", "authors": "Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "22113612", "url": "https://glygen.org/publication/PubMed/22113612" } ] }, { "title": "Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes.", "journal": "IUBMB life", "date": "2012", "authors": "Sadowski M, Suryadinata R, Tan AR, Roesley SN, Sarcevic B", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "22131221", "url": "https://glygen.org/publication/PubMed/22131221" } ] }, { "title": "Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells.", "journal": "Cell", "date": "2011", "authors": "Cebrian I, Visentin G, Blanchard N, Jouve M, Bobard A, Moita C, Enninga J, Moita LF, Amigorena S, Savina A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974" } ], "reference": [ { "type": "PubMed", "id": "22153078", "url": "https://glygen.org/publication/PubMed/22153078" } ] }, { "title": "MEK1/2 dual-specificity protein kinases: structure and regulation.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Roskoski R Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "22177953", "url": "https://glygen.org/publication/PubMed/22177953" } ] }, { "title": "Mechanism of RAF isoform switching induced by oncogenic RAS in melanoma.", "journal": "Small GTPases", "date": "2011", "authors": "Dumaz N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "22292133", "url": "https://glygen.org/publication/PubMed/22292133" } ] }, { "title": "The extracellular release of DNA and HMGB1 from Jurkat T cells during in vitro necrotic cell death.", "journal": "Innate immunity", "date": "2012", "authors": "Beyer C, Stearns NA, Giessl A, Distler JH, Schett G, Pisetsky DS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "22344226", "url": "https://glygen.org/publication/PubMed/22344226" } ] }, { "title": "Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.", "journal": "The New England journal of medicine", "date": "2012", "authors": "Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Hersey P, Kefford R, Lawrence D, Puzanov I, Lewis KD, Amaravadi RK, Chmielowski B, Lawrence HJ, Shyr Y, Ye F, Li J, Nolop KB, Lee RJ, Joe AK, Ribas A", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "22356324", "url": "https://glygen.org/publication/PubMed/22356324" } ] }, { "title": "Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance.", "journal": "Nature communications", "date": "2012", "authors": "Shi H, Moriceau G, Kong X, Lee MK, Lee H, Koya RC, Ng C, Chodon T, Scolyer RA, Dahlman KB, Sosman JA, Kefford RF, Long GV, Nelson SF, Ribas A, Lo RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "22395615", "url": "https://glygen.org/publication/PubMed/22395615" } ] }, { "title": "Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Lee KG, Xu S, Kang ZH, Huo J, Huang M, Liu D, Takeuchi O, Akira S, Lam KP", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "22454496", "url": "https://glygen.org/publication/PubMed/22454496" } ] }, { "title": "Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes.", "journal": "International journal of molecular sciences", "date": "2012", "authors": "Vogl T, Gharibyan AL, Morozova-Roche LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "22489132", "url": "https://glygen.org/publication/PubMed/22489132" } ] }, { "title": "Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling.", "journal": "The EMBO journal", "date": "2012", "authors": "Roring M, Herr R, Fiala GJ, Heilmann K, Braun S, Eisenhardt AE, Halbach S, Capper D, von Deimling A, Schamel WW, Saunders DN, Brummer T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "22510884", "url": "https://glygen.org/publication/PubMed/22510884" } ] }, { "title": "Tetrastatin, the NC1 domain of the alpha4(IV) collagen chain: a novel potent anti-tumor matrikine.", "journal": "PloS one", "date": "2012", "authors": "Brassart-Pasco S, Senechal K, Thevenard J, Ramont L, Devy J, Di Stefano L, Dupont-Deshorgue A, Brezillon S, Feru J, Jazeron JF, Diebold MD, Ricard-Blum S, Maquart FX, Monboisse JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "22539938", "url": "https://glygen.org/publication/PubMed/22539938" } ] }, { "title": "ERK1/2 MAP kinases: structure, function, and regulation.", "journal": "Pharmacological research", "date": "2012", "authors": "Roskoski R Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "22569528", "url": "https://glygen.org/publication/PubMed/22569528" } ] }, { "title": "A comprehensive survey of Ras mutations in cancer.", "journal": "Cancer research", "date": "2012", "authors": "Prior IA, Lewis PD, Mattos C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "22589270", "url": "https://glygen.org/publication/PubMed/22589270" } ] }, { "title": "Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.", "journal": "Blood", "date": "2012", "authors": "Li W, Huntington JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "22618708", "url": "https://glygen.org/publication/PubMed/22618708" } ] }, { "title": "A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation.", "journal": "PloS one", "date": "2012", "authors": "Lee NV, Lira ME, Pavlicek A, Ye J, Buckman D, Bagrodia S, Srinivasa SP, Zhao Y, Aparicio S, Rejto PA, Christensen JG, Ching KA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "22745804", "url": "https://glygen.org/publication/PubMed/22745804" } ] }, { "title": "Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.", "journal": "Molecular and cellular biology", "date": "2012", "authors": "Wu X, Yin J, Simpson J, Kim KH, Gu S, Hong JH, Bayliss P, Backx PH, Neel BG, Araki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "22826437", "url": "https://glygen.org/publication/PubMed/22826437" } ] }, { "title": "Fibrinogen gene regulation.", "journal": "Thrombosis and haemostasis", "date": "2012", "authors": "Fish RJ, Neerman-Arbez M", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" } ], "reference": [ { "type": "PubMed", "id": "22836683", "url": "https://glygen.org/publication/PubMed/22836683" } ] }, { "title": "Target-derived matricryptins organize cerebellar synapse formation through alpha3beta1 integrins.", "journal": "Cell reports", "date": "2012", "authors": "Su J, Stenbjorn RS, Gorse K, Su K, Hauser KF, Ricard-Blum S, Pihlajaniemi T, Fox MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "22884367", "url": "https://glygen.org/publication/PubMed/22884367" } ] }, { "title": "Glycoproteomic analysis of human fibrinogen reveals novel regions of O-glycosylation.", "journal": "Journal of proteome research", "date": "2012", "authors": "Zauner G, Hoffmann M, Rapp E, Koeleman CA, Dragan I, Deelder AM, Wuhrer M, Hensbergen PJ", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "23050552", "url": "https://glygen.org/publication/PubMed/23050552" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis.", "journal": "Journal of proteome research", "date": "2013", "authors": "Adamczyk B, Struwe WB, Ercan A, Nigrovic PA, Rudd PM", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "23151259", "url": "https://glygen.org/publication/PubMed/23151259" } ] }, { "title": "Elucidating distinct roles for NF1 in melanomagenesis.", "journal": "Cancer discovery", "date": "2013", "authors": "Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "23171796", "url": "https://glygen.org/publication/PubMed/23171796" } ] }, { "title": "A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.", "journal": "Cancer discovery", "date": "2013", "authors": "Whittaker SR, Theurillat JP, Van Allen E, Wagle N, Hsiao J, Cowley GS, Schadendorf D, Root DE, Garraway LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "23288408", "url": "https://glygen.org/publication/PubMed/23288408" } ] }, { "title": "Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.", "journal": "Molecular cell", "date": "2013", "authors": "Freeman AK, Ritt DA, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "23352452", "url": "https://glygen.org/publication/PubMed/23352452" } ] }, { "title": "Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells.", "journal": "The FEBS journal", "date": "2013", "authors": "Willis CD, Poluzzi C, Mongiat M, Iozzo RV", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "23374253", "url": "https://glygen.org/publication/PubMed/23374253" } ] }, { "title": "The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.", "journal": "Journal of leukocyte biology", "date": "2013", "authors": "Yang H, Antoine DJ, Andersson U, Tracey KJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "23446148", "url": "https://glygen.org/publication/PubMed/23446148" } ] }, { "title": "Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.", "journal": "Cancer cell", "date": "2013", "authors": "Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "23453624", "url": "https://glygen.org/publication/PubMed/23453624" } ] }, { "title": "Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.", "journal": "Nature genetics", "date": "2013", "authors": "Zhang J, Wu G, Miller CP, Tatevossian RG, Dalton JD, Tang B, Orisme W, Punchihewa C, Parker M, Qaddoumi I, Boop FA, Lu C, Kandoth C, Ding L, Lee R, Huether R, Chen X, Hedlund E, Nagahawatte P, Rusch M, Boggs K, Cheng J, Becksfort J, Ma J, Song G, Li Y, Wei L, Wang J, Shurtleff S, Easton J, Zhao D, Fulton RS, Fulton LL, Dooling DJ, Vadodaria B, Mulder HL, Tang C, Ochoa K, Mullighan CG, Gajjar A, Kriwacki R, Sheer D, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Baker SJ, Ellison DW", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "23583981", "url": "https://glygen.org/publication/PubMed/23583981" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "P02671", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "IkappaB kinase phosphorylation of SNAP-23 controls platelet secretion.", "journal": "Blood", "date": "2013", "authors": "Karim ZA, Zhang J, Banerjee M, Chicka MC, Al Hawas R, Hamilton TR, Roche PA, Whiteheart SW", "evidence": [ { "database": "Reactome", "id": "R-HSA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974" } ], "reference": [ { "type": "PubMed", "id": "23613522", "url": "https://glygen.org/publication/PubMed/23613522" } ] }, { "title": "Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.", "journal": "Cancer discovery", "date": "2013", "authors": "Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, Long B, Liu J, Dinunzio E, Windsor W, Zhang R, Zhao S, Angagaw MH, Pinheiro EM, Desai J, Xiao L, Shipps G, Hruza A, Wang J, Kelly J, Paliwal S, Gao X, Babu BS, Zhu L, Daublain P, Zhang L, Lutterbach BA, Pelletier MR, Philippar U, Siliphaivanh P, Witter D, Kirschmeier P, Bishop WR, Hicklin D, Gilliland DG, Jayaraman L, Zawel L, Fawell S, Samatar AA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "23614898", "url": "https://glygen.org/publication/PubMed/23614898" } ] }, { "title": "High precision platelet releasate definition by quantitative reversed protein profiling--brief report.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2013", "authors": "Wijten P, van Holten T, Woo LL, Bleijerveld OB, Roest M, Heck AJ, Scholten A", "evidence": [ { "database": "Reactome", "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608" } ], "reference": [ { "type": "PubMed", "id": "23640497", "url": "https://glygen.org/publication/PubMed/23640497" } ] }, { "title": "Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.", "journal": "Cancer research", "date": "2013", "authors": "Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "23667175", "url": "https://glygen.org/publication/PubMed/23667175" } ] }, { "title": "RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.", "journal": "Cancer cell", "date": "2013", "authors": "Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, Tellew J, Hardy S, Hekmat-Nejad M, Stuart DD, McCormick F, Nagel TE", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955" } ], "reference": [ { "type": "PubMed", "id": "23680146", "url": "https://glygen.org/publication/PubMed/23680146" } ] }, { "title": "Efficacy and toxicity of factor Xa inhibitors.", "journal": "Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques", "date": "2013", "authors": "Bondarenko M, Curti C, Montana M, Rathelot P, Vanelle P", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "23683607", "url": "https://glygen.org/publication/PubMed/23683607" } ] }, { "title": "Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease.", "journal": "Journal of cell science", "date": "2013", "authors": "Willnow TE, Andersen OM", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "23813966", "url": "https://glygen.org/publication/PubMed/23813966" } ] }, { "title": "The RASopathies.", "journal": "Annual review of genomics and human genetics", "date": "2013", "authors": "Rauen KA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "23875798", "url": "https://glygen.org/publication/PubMed/23875798" } ] }, { "title": "Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.", "journal": "Nature", "date": "2013", "authors": "Hatzivassiliou G, Haling JR, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "23934108", "url": "https://glygen.org/publication/PubMed/23934108" } ] }, { "title": "Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis. A histochemical study.", "journal": "Laboratory investigation; a journal of technical methods and pathology", "date": "1985", "authors": "Snow AD, Kisilevsky R", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "2409350", "url": "https://glygen.org/publication/PubMed/2409350" } ] }, { "title": "MEK in cancer and cancer therapy.", "journal": "Pharmacology & therapeutics", "date": "2014", "authors": "Neuzillet C, Tijeras-Raballand A, de Mestier L, Cros J, Faivre S, Raymond E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "24121058", "url": "https://glygen.org/publication/PubMed/24121058" } ] }, { "title": "Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.", "journal": "The Journal of clinical investigation", "date": "2013", "authors": "Ricarte-Filho JC, Li S, Garcia-Rendueles ME, Montero-Conde C, Voza F, Knauf JA, Heguy A, Viale A, Bogdanova T, Thomas GA, Mason CE, Fagin JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "24135138", "url": "https://glygen.org/publication/PubMed/24135138" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Tumor adaptation and resistance to RAF inhibitors.", "journal": "Nature medicine", "date": "2013", "authors": "Lito P, Rosen N, Solit DB", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "24202393", "url": "https://glygen.org/publication/PubMed/24202393" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.", "journal": "Molecular immunology", "date": "2014", "authors": "Yamamoto T, Tsutsumi N, Tochio H, Ohnishi H, Kubota K, Kato Z, Shirakawa M, Kondo N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5603041", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5603041" } ], "reference": [ { "type": "PubMed", "id": "24316379", "url": "https://glygen.org/publication/PubMed/24316379" } ] }, { "title": "BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2013", "authors": "Hutchinson KE, Lipson D, Stephens PJ, Otto G, Lehmann BD, Lyle PL, Vnencak-Jones CL, Ross JS, Pietenpol JA, Sosman JA, Puzanov I, Miller VA, Pao W", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "24345920", "url": "https://glygen.org/publication/PubMed/24345920" } ] }, { "title": "Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface.", "journal": "PLoS Pathog.", "date": "2013", "authors": "Ko Ya-Ping, Kuipers Annemarie, Freitag Claudia M, Jongerius Ilse, Medina Eva, van Rooijen Willemien J, Spaan Andr\u00e1s N, van Kessel Kok P M, H\u00f6\u00f6k Magnus, Rooijakkers Suzan H M", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "24348255", "url": "https://glygen.org/publication/PubMed/24348255" } ] }, { "title": "The new factor Xa inhibitor: Apixaban.", "journal": "Journal of pharmacology & pharmacotherapeutics", "date": "2014", "authors": "Bhanwra S, Ahluwalia K", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "24554904", "url": "https://glygen.org/publication/PubMed/24554904" } ] }, { "title": "Dragging ras back in the ring.", "journal": "Cancer cell", "date": "2014", "authors": "Stephen AG, Esposito D, Bagni RK, McCormick F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9649948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948" } ], "reference": [ { "type": "PubMed", "id": "24651010", "url": "https://glygen.org/publication/PubMed/24651010" } ] }, { "title": "Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.", "journal": "Cancer cell", "date": "2014", "authors": "Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "24746704", "url": "https://glygen.org/publication/PubMed/24746704" } ] }, { "title": "Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1989", "authors": "Baxter RC, Martin JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "2476804", "url": "https://glygen.org/publication/PubMed/2476804" } ] }, { "title": "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2).", "journal": "The EMBO journal", "date": "1989", "authors": "Binkert C, Landwehr J, Mary JL, Schwander J, Heinrich G", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "2479552", "url": "https://glygen.org/publication/PubMed/2479552" } ] }, { "title": "The Role of SORL1 in Alzheimer's Disease.", "journal": "Molecular neurobiology", "date": "2015", "authors": "Yin RH, Yu JT, Tan L", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "24833601", "url": "https://glygen.org/publication/PubMed/24833601" } ] }, { "title": "S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.", "journal": "EMBO molecular medicine", "date": "2014", "authors": "Rohde D, Schon C, Boerries M, Didrihsone I, Ritterhoff J, Kubatzky KF, Volkers M, Herzog N, Mahler M, Tsoporis JN, Parker TG, Linke B, Giannitsis E, Gao E, Peppel K, Katus HA, Most P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "24833748", "url": "https://glygen.org/publication/PubMed/24833748" } ] }, { "title": "The normal and pathologic roles of the Alzheimer's beta-secretase, BACE1.", "journal": "Current Alzheimer research", "date": "2014", "authors": "Kandalepas PC, Vassar R", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "24893886", "url": "https://glygen.org/publication/PubMed/24893886" } ] }, { "title": "`RAF` neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway.", "journal": "FEBS letters", "date": "2014", "authors": "Cseh B, Doma E, Baccarini M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "24937142", "url": "https://glygen.org/publication/PubMed/24937142" } ] }, { "title": "Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.", "journal": "Nature reviews. Cancer", "date": "2014", "authors": "Holderfield M, Deuker MM, McCormick F, McMahon M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946" } ], "reference": [ { "type": "PubMed", "id": "24957944", "url": "https://glygen.org/publication/PubMed/24957944" } ] }, { "title": "TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.", "journal": "Cell", "date": "2014", "authors": "Nair-Gupta P, Baccarini A, Tung N, Seyffer F, Florey O, Huang Y, Banerjee M, Overholtzer M, Roche PA, Tampe R, Brown BD, Amsen D, Whiteheart SW, Blander JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1236974", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974" } ], "reference": [ { "type": "PubMed", "id": "25083866", "url": "https://glygen.org/publication/PubMed/25083866" } ] }, { "title": "A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.", "journal": "Nature chemical biology", "date": "2014", "authors": "Chaikuad A, Tacconi EM, Zimmer J, Liang Y, Gray NS, Tarsounas M, Knapp S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "25195011", "url": "https://glygen.org/publication/PubMed/25195011" } ] }, { "title": "The landscape of kinase fusions in cancer.", "journal": "Nature communications", "date": "2014", "authors": "Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802952", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952" } ], "reference": [ { "type": "PubMed", "id": "25204415", "url": "https://glygen.org/publication/PubMed/25204415" } ] }, { "title": "Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.", "journal": "Journal of medicinal chemistry", "date": "2014", "authors": "Deng Y, Shipps GW Jr, Cooper A, English JM, Annis DA, Carr D, Nan Y, Wang T, Zhu HY, Chuang CC, Dayananth P, Hruza AW, Xiao L, Jin W, Kirschmeier P, Windsor WT, Samatar AA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "25313996", "url": "https://glygen.org/publication/PubMed/25313996" } ] }, { "title": "The roles of protein C and thrombomodulin in the regulation of blood coagulation.", "journal": "The Journal of biological chemistry", "date": "1989", "authors": "Esmon CT", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "2538457", "url": "https://glygen.org/publication/PubMed/2538457" } ] }, { "title": "Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.", "journal": "Thrombosis and haemostasis", "date": "2015", "authors": "Asselta R, Plate M, Robusto M, Borhany M, Guella I, Solda G, Afrasiabi A, Menegatti M, Shamsi T, Peyvandi F, Duga S", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "25427968", "url": "https://glygen.org/publication/PubMed/25427968" } ] }, { "title": "Targeting RAS-ERK signalling in cancer: promises and challenges.", "journal": "Nature reviews. Drug discovery", "date": "2014", "authors": "Samatar AA, Poulikakos PI", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802946", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946" } ], "reference": [ { "type": "PubMed", "id": "25435214", "url": "https://glygen.org/publication/PubMed/25435214" } ] }, { "title": "Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.", "journal": "Current Alzheimer research", "date": "2015", "authors": "Baranello RJ, Bharani KL, Padmaraju V, Chopra N, Lahiri DK, Greig NH, Pappolla MA, Sambamurti K", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "25523424", "url": "https://glygen.org/publication/PubMed/25523424" } ] }, { "title": "Edoxaban, a Novel Oral Factor Xa Inhibitor.", "journal": "The Annals of pharmacotherapy", "date": "2015", "authors": "Minor C, Tellor KB, Armbruster AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "25855704", "url": "https://glygen.org/publication/PubMed/25855704" } ] }, { "title": "Role of S100A1 in hypoxia-induced inflammatory response in cardiomyocytes via TLR4/ROS/NF-kappaB pathway.", "journal": "The Journal of pharmacy and pharmacology", "date": "2015", "authors": "Yu J, Lu Y, Li Y, Xiao L, Xing Y, Li Y, Wu L", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "25880347", "url": "https://glygen.org/publication/PubMed/25880347" } ] }, { "title": "Regulation of RAF protein kinases in ERK signalling.", "journal": "Nature reviews. Molecular cell biology", "date": "2015", "authors": "Lavoie H, Therrien M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6802948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948" } ], "reference": [ { "type": "PubMed", "id": "25907612", "url": "https://glygen.org/publication/PubMed/25907612" } ] }, { "title": "Abeta42 and Abeta40: similarities and differences.", "journal": "Journal of peptide science : an official publication of the European Peptide Society", "date": "2015", "authors": "Qiu T, Liu Q, Chen YX, Zhao YF, Li YM", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "26018760", "url": "https://glygen.org/publication/PubMed/26018760" } ] }, { "title": "A Single Kinase Generates the Majority of the Secreted Phosphoproteome.", "journal": "Cell", "date": "2015", "authors": "Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" }, { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "reference": [ { "type": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ] }, { "title": "Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.", "journal": "Nature genetics", "date": "2015", "authors": "Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9656223", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223" } ], "reference": [ { "type": "PubMed", "id": "26214590", "url": "https://glygen.org/publication/PubMed/26214590" } ] }, { "title": "Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease.", "journal": "Neurobiology of aging", "date": "2015", "authors": "Ahmadian SS, Rezvanian A, Peterson M, Weintraub S, Bigio EH, Mesulam MM, Geula C", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "26417681", "url": "https://glygen.org/publication/PubMed/26417681" } ] }, { "title": "Site-specific O-Glycosylation Analysis of Human Blood Plasma Proteins.", "journal": "Molecular & cellular proteomics : MCP", "date": "2016", "authors": "Hoffmann M, Marx K, Reichl U, Wuhrer M, Rapp E", "evidence": [ { "database": "UniCarbKB", "id": "P02671", "url": "" } ], "reference": [ { "type": "PubMed", "id": "26598643", "url": "https://glygen.org/publication/PubMed/26598643" } ] }, { "title": "TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Noy PJ, Yang J, Reyat JS, Matthews AL, Charlton AE, Furmston J, Rogers DA, Rainger GE, Tomlinson MG", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "26668317", "url": "https://glygen.org/publication/PubMed/26668317" } ] }, { "title": "TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2016", "authors": "Jouannet S, Saint-Pol J, Fernandez L, Nguyen V, Charrin S, Boucheix C, Brou C, Milhiet PE, Rubinstein E", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "26686862", "url": "https://glygen.org/publication/PubMed/26686862" } ] }, { "title": "Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies.", "journal": "Neural regeneration research", "date": "2015", "authors": "Hermey G", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "26807092", "url": "https://glygen.org/publication/PubMed/26807092" } ] }, { "title": "Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-y l)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.", "journal": "Journal of medicinal chemistry", "date": "2016", "authors": "Blake JF, Burkard M, Chan J, Chen H, Chou KJ, Diaz D, Dudley DA, Gaudino JJ, Gould SE, Grina J, Hunsaker T, Liu L, Martinson M, Moreno D, Mueller L, Orr C, Pacheco P, Qin A, Rasor K, Ren L, Robarge K, Shahidi-Latham S, Stults J, Sullivan F, Wang W, Yin J, Zhou A, Belvin M, Merchant M, Moffat J, Schwarz JB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "27227380", "url": "https://glygen.org/publication/PubMed/27227380" } ] }, { "title": "High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen.", "journal": "Biochemistry", "date": "1989", "authors": "Ni F, Konishi Y, Frazier RB, Scheraga HA, Lord ST", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "2742826", "url": "https://glygen.org/publication/PubMed/2742826" } ] }, { "title": "Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1978", "authors": "Costa PP, Figueira AS, Bravo FR", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "279930", "url": "https://glygen.org/publication/PubMed/279930" } ] }, { "title": "Regulation of formation of factor XIIIa by its fibrin substrates.", "journal": "Biochemistry", "date": "1985", "authors": "Lewis SD, Janus TJ, Lorand L, Shafer JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "2866798", "url": "https://glygen.org/publication/PubMed/2866798" } ] }, { "title": "Cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.", "journal": "J. Biol. Chem.", "date": "1986", "authors": "Kimura S, Aoki N", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "2877981", "url": "https://glygen.org/publication/PubMed/2877981" } ] }, { "title": "Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).", "journal": "Molecular cancer therapeutics", "date": "2017", "authors": "Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "28939558", "url": "https://glygen.org/publication/PubMed/28939558" } ] }, { "title": "Mutation in cystatin C gene causes hereditary brain haemorrhage.", "journal": "Lancet (London, England)", "date": "1988", "authors": "Palsdottir A, Abrahamson M, Thorsteinsson L, Arnason A, Olafsson I, Grubb A, Jensson O", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "2900981", "url": "https://glygen.org/publication/PubMed/2900981" } ] }, { "title": "Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors.", "journal": "JCI insight", "date": "2018", "authors": "Moschos SJ, Sullivan RJ, Hwu WJ, Ramanathan RK, Adjei AA, Fong PC, Shapira-Frommer R, Tawbi HA, Rubino J, Rush TS 3rd, Zhang D, Miselis NR, Samatar AA, Chun P, Rubin EH, Schiller J, Long BJ, Dayananth P, Carr D, Kirschmeier P, Bishop WR, Deng Y, Cooper A, Shipps GW, Moreno BH, Robert L, Ribas A, Flaherty KT", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "29467321", "url": "https://glygen.org/publication/PubMed/29467321" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "GlyConnect", "id": "1238", "url": "https://glyconnect.expasy.org/browser/proteins/1238" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "title": "MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.", "journal": "ACS medicinal chemistry letters", "date": "2018", "authors": "Boga SB, Deng Y, Zhu L, Nan Y, Cooper AB, Shipps GW Jr, Doll R, Shih NY, Zhu H, Sun R, Wang T, Paliwal S, Tsui HC, Gao X, Yao X, Desai J, Wang J, Alhassan AB, Kelly J, Patel M, Muppalla K, Gudipati S, Zhang LK, Buevich A, Hesk D, Carr D, Dayananth P, Black S, Mei H, Cox K, Sherborne B, Hruza AW, Xiao L, Jin W, Long B, Liu G, Taylor SA, Kirschmeier P, Windsor WT, Bishop R, Samatar AA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "30034615", "url": "https://glygen.org/publication/PubMed/30034615" } ] }, { "title": "Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1987", "authors": "Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "3035556", "url": "https://glygen.org/publication/PubMed/3035556" } ] }, { "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "date": "2018", "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "P02671", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "title": "Cofactor proteins in the assembly and expression of blood clotting enzyme complexes.", "journal": "Annual review of biochemistry", "date": "1988", "authors": "Mann KG, Jenny RJ, Krishnaswamy S", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "3052293", "url": "https://glygen.org/publication/PubMed/3052293" } ] }, { "title": "An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing.", "journal": "The Journal of biological chemistry", "date": "1988", "authors": "Sanke T, Bell GI, Sample C, Rubenstein AH, Steiner DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "3053705", "url": "https://glygen.org/publication/PubMed/3053705" } ] }, { "title": "Targeting ERK1/2 protein-serine/threonine kinases in human cancers.", "journal": "Pharmacological research", "date": "2019", "authors": "Roskoski R Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "30794926", "url": "https://glygen.org/publication/PubMed/30794926" } ] }, { "title": "Serum levels of beta 2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis.", "journal": "The New England journal of medicine", "date": "1986", "authors": "Gejyo F, Homma N, Suzuki Y, Arakawa M", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "3080684", "url": "https://glygen.org/publication/PubMed/3080684" } ] }, { "title": "Assignment of the human and mouse prion protein genes to homologous chromosomes.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1986", "authors": "Sparkes RS, Simon M, Cohn VH, Fournier RE, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "3094007", "url": "https://glygen.org/publication/PubMed/3094007" } ] }, { "title": "Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.", "journal": "Biochemical and biophysical research communications", "date": "1988", "authors": "Nichols WC, Dwulet FE, Liepnieks J, Benson MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "3142462", "url": "https://glygen.org/publication/PubMed/3142462" } ] }, { "title": "Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1988", "authors": "Ray LB, Sturgill TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "3287375", "url": "https://glygen.org/publication/PubMed/3287375" } ] }, { "title": "Two novel heterozygous mutations (p.\u03b3Phe230Val and p.A\u03b1Asn839Thr) cause hereditary hypodysfibrinogenemia in two Chinese independent families.", "journal": "Acta haematologica", "date": "2023-01-04", "authors": "Ge Shengchen, Luo Yuqing, Dong Rujiao, Guo Xiaoli, Wang Mingshan, Chen Yi", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" } ], "reference": [ { "type": "PubMed", "id": "36599322", "url": "https://glygen.org/publication/PubMed/36599322" } ] }, { "title": "Serum amyloid P component is the major calcium-dependent specific DNA binding protein of the serum.", "journal": "Biochemical and biophysical research communications", "date": "1987", "authors": "Pepys MB, Butler PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "3675579", "url": "https://glygen.org/publication/PubMed/3675579" } ] }, { "title": "Fibrinogen-A\u03b1 THR312ALA Polymorphism is Associated to Chronic Thromboembolic Pulmonary Hypertension in Turkey.", "journal": "Anatolian journal of cardiology", "date": "2023-03", "authors": "\u00c7\u00f6rt\u00fck Mustafa, Y\u0131ld\u0131zeli Bedrettin, Kurar Ercan, Kay\u0131\u015f Seyit Ali, Tanr\u0131verdi Elif, \u00c7etinkaya Erdo\u011fan", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" } ], "reference": [ { "type": "PubMed", "id": "36856592", "url": "https://glygen.org/publication/PubMed/36856592" } ] }, { "title": "Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients.", "journal": "Journal of cardiothoracic and vascular anesthesia", "date": "2023-02-20", "authors": "Maslow Andrew, Cheves Tracey, Joyce Maurice Frankie, Apruzzese Patricia, Sweeney Joseph", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" } ], "reference": [ { "type": "PubMed", "id": "36933991", "url": "https://glygen.org/publication/PubMed/36933991" } ] }, { "title": "Heparin and its low molecular weight derivatives: anticoagulant and antithrombotic properties.", "journal": "Haemostasis", "date": "1986", "authors": "Holmer E, Soderberg K, Bergqvist D, Lindahl U", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "3744129", "url": "https://glygen.org/publication/PubMed/3744129" } ] }, { "title": "[Genetic analysis of a Chinese pedigree affected with Congenital dysfibrinogenemia due to variant of FGG gene].", "journal": "Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics", "date": "2023-11-10", "authors": "Shao Xiuru, Ma Jun, Wang Zhiguo, Sun Mingyan, Huang Zhan, Jiang Zhao, Liu Xiaojuan, Li Si, Liu Yu", "evidence": [ { "database": "RefSeq", "id": "NP_000499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000499" } ], "reference": [ { "type": "PubMed", "id": "37906135", "url": "https://glygen.org/publication/PubMed/37906135" } ] }, { "title": "Inhibition of chymotrypsin by heparin cofactor II.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1985", "authors": "Church FC, Noyes CM, Griffith MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "3863104", "url": "https://glygen.org/publication/PubMed/3863104" } ] }, { "title": "Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites.", "journal": "Biochemistry", "date": "1979", "authors": "Cottrell B A, Strong D D, Watt K W, Doolittle R F", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "518845", "url": "https://glygen.org/publication/PubMed/518845" } ] }, { "title": "Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence.", "journal": "Biochemistry", "date": "1979", "authors": "Watt K W, Cottrell B A, Strong D D, Doolittle R F", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "518846", "url": "https://glygen.org/publication/PubMed/518846" } ] }, { "title": "Phosphorylation of human fibrinogen in vitro with cyclic 3',5'-AMP-stimulated protein kinase and (32P)ATP.", "journal": "Biochemical and biophysical research communications", "date": "1980", "authors": "Engstrom L, Edlund B, Ragnarsson U, Dahlqvist-Edberg U, Humble E", "evidence": [ { "database": "iPTMnet", "id": "P02671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671" } ], "reference": [ { "type": "PubMed", "id": "6255944", "url": "https://glygen.org/publication/PubMed/6255944" } ] }, { "title": "Phosphorylation of fibrinogen by casein kinase 1.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1983", "authors": "Itarte E, Plana M, Guasch M D, Martos C", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "6318767", "url": "https://glygen.org/publication/PubMed/6318767" } ] }, { "title": "Localization of the alpha-chain cross-link acceptor sites of human fibrin.", "journal": "J. Biol. Chem.", "date": "1978", "authors": "Fretto L J, Ferguson E W, Steinman H M, McKee P A", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "632262", "url": "https://glygen.org/publication/PubMed/632262" } ] }, { "title": "Mechanism of inhibition of activated protein C by protein C inhibitor.", "journal": "Journal of biochemistry", "date": "1984", "authors": "Suzuki K, Nishioka J, Kusumoto H, Hashimoto S", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "6323392", "url": "https://glygen.org/publication/PubMed/6323392" } ] }, { "title": "Fibrinogen and fibrin.", "journal": "Annu. Rev. Biochem.", "date": "1984", "authors": "Doolittle RF", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "6383194", "url": "https://glygen.org/publication/PubMed/6383194" } ] }, { "title": "Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.", "journal": "Biochimica et biophysica acta", "date": "1981", "authors": "Gogstad GO, Hagen I, Korsmo R, Solum NO", "evidence": [ { "database": "Reactome", "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608" } ], "reference": [ { "type": "PubMed", "id": "6457647", "url": "https://glygen.org/publication/PubMed/6457647" } ] }, { "title": "Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1983", "authors": "Kant J A, Lord S T, Crabtree G R", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "6575389", "url": "https://glygen.org/publication/PubMed/6575389" } ] }, { "title": "Cloning of fibrinogen genes and their cDNA.", "journal": "Ann. N. Y. Acad. Sci.", "date": "1983", "authors": "Chung D W, Rixon M W, Que B G, Davie E W", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "6575700", "url": "https://glygen.org/publication/PubMed/6575700" } ] }, { "title": "Characterization of a complementary deoxyribonucleic acid coding for the alpha chain of human fibrinogen.", "journal": "Biochemistry", "date": "1983", "authors": "Rixon M W, Chan W Y, Davie E W, Chung D W", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "6688355", "url": "https://glygen.org/publication/PubMed/6688355" } ] }, { "title": "Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen.", "journal": "Nucleic Acids Res.", "date": "1983", "authors": "Imam A M, Eaton M A, Williamson R, Humphries S", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "6689067", "url": "https://glygen.org/publication/PubMed/6689067" } ] }, { "title": "The location of a second in vivo phosphorylation site in the A alpha-chain of human fibrinogen.", "journal": "Thrombosis research", "date": "1984", "authors": "Seydewitz HH, Kaiser C, Rothweiler H, Witt I", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "6719396", "url": "https://glygen.org/publication/PubMed/6719396" } ] }, { "title": "Carbohydrate structure of human fibrinogen. Use of 300-MHz 1H-NMR to characterize glycosidase-treated glycopeptides.", "journal": "The Journal of biological chemistry", "date": "1982", "authors": "Townsend RR, Hilliker E, Li YT, Laine RA, Bell WR, Lee YC", "evidence": [ { "database": "GlyConnect", "id": "157", "url": "https://glyconnect.expasy.org/browser/proteins/157" } ], "reference": [ { "type": "PubMed", "id": "7107587", "url": "https://glygen.org/publication/PubMed/7107587" } ] }, { "title": "Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences.", "journal": "Biochemistry", "date": "1980", "authors": "Laudano AP, Doolittle RF", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "7356959", "url": "https://glygen.org/publication/PubMed/7356959" } ] }, { "title": "The arrangement of disulfide bonds in fragment D from human fibrinogen.", "journal": "Thrombosis research", "date": "1978", "authors": "Bouma H, Takagi T, Doolittle RF", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "741445", "url": "https://glygen.org/publication/PubMed/741445" } ] }, { "title": "Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Rosing J, Hoekema L, Nicolaes GA, Thomassen MC, Hemker HC, Varadi K, Schwarz HP, Tans G", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "7499257", "url": "https://glygen.org/publication/PubMed/7499257" } ] }, { "title": "Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the alpha v beta 3 receptor.", "journal": "Blood", "date": "1993", "authors": "Denis C, Williams JA, Lu X, Meyer D, Baruch D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7505120", "url": "https://glygen.org/publication/PubMed/7505120" } ] }, { "title": "Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.", "journal": "The Journal of experimental medicine", "date": "1994", "authors": "Kurosaki T, Takata M, Yamanashi Y, Inazu T, Taniguchi T, Yamamoto T, Yamamura H", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "7513017", "url": "https://glygen.org/publication/PubMed/7513017" } ] }, { "title": "Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Arai T, Parker A, Busby W Jr, Clemmons DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7519608", "url": "https://glygen.org/publication/PubMed/7519608" } ] }, { "title": "Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Fowlkes JL, Enghild JJ, Suzuki K, Nagase H", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7523391", "url": "https://glygen.org/publication/PubMed/7523391" } ] }, { "title": "Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts.", "journal": "Endocrinology", "date": "1994", "authors": "Bach LA, Hsieh S, Brown AL, Rechler MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7525263", "url": "https://glygen.org/publication/PubMed/7525263" } ] }, { "title": "Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Nishimura SL, Sheppard D, Pytela R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7525578", "url": "https://glygen.org/publication/PubMed/7525578" } ] }, { "title": "Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1994", "authors": "Lee KO, Oh Y, Giudice LC, Cohen P, Peehl DM, Rosenfeld RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7525634", "url": "https://glygen.org/publication/PubMed/7525634" } ] }, { "title": "Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease.", "journal": "The Journal of endocrinology", "date": "1994", "authors": "Cohen P, Peehl DM, Graves HC, Rosenfeld RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7525824", "url": "https://glygen.org/publication/PubMed/7525824" } ] }, { "title": "Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells.", "journal": "Endocrinology", "date": "1994", "authors": "Lalou C, Silve C, Rosato R, Segovia B, Binoux M", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7527330", "url": "https://glygen.org/publication/PubMed/7527330" } ] }, { "title": "Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3.", "journal": "Growth regulation", "date": "1994", "authors": "Fielder PJ, Rosenfeld RG, Graves HC, Grandbois K, Maack CA, Sawamura S, Ogawa Y, Sommer A, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7538844", "url": "https://glygen.org/publication/PubMed/7538844" } ] }, { "title": "The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.", "journal": "Neuron", "date": "1995", "authors": "Varnum-Finney B, Venstrom K, Muller U, Kypta R, Backus C, Chiquet M, Reichardt LF", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7541634", "url": "https://glygen.org/publication/PubMed/7541634" } ] }, { "title": "CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.", "journal": "The Journal of cell biology", "date": "1995", "authors": "Piali L, Hammel P, Uherek C, Bachmann F, Gisler RH, Dunon D, Imhof BA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7542249", "url": "https://glygen.org/publication/PubMed/7542249" } ] }, { "title": "Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1995", "authors": "Juul A, Dalgaard P, Blum WF, Bang P, Hall K, Michaelsen KF, Muller J, Skakkebaek NE", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7543116", "url": "https://glygen.org/publication/PubMed/7543116" } ] }, { "title": "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7559467", "url": "https://glygen.org/publication/PubMed/7559467" } ] }, { "title": "A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Catling AD, Schaeffer HJ, Reuter CW, Reddy GR, Weber MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "7565670", "url": "https://glygen.org/publication/PubMed/7565670" } ] }, { "title": "Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells.", "journal": "Molecular and cellular biology", "date": "1995", "authors": "Pritchard CA, Samuels ML, Bosch E, McMahon M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "7565795", "url": "https://glygen.org/publication/PubMed/7565795" } ] }, { "title": "Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3).", "journal": "Endocrinology", "date": "1995", "authors": "Angelloz-Nicoud P, Binoux M", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7588299", "url": "https://glygen.org/publication/PubMed/7588299" } ] }, { "title": "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Bach LA, Hsieh S, Sakano K, Fujiwara H, Perdue JF, Rechler MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7683646", "url": "https://glygen.org/publication/PubMed/7683646" } ] }, { "title": "The alpha v beta 5 integrin receptor regulates receptor-mediated endocytosis of vitronectin.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Panetti TS, McKeown-Longo PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "7685013", "url": "https://glygen.org/publication/PubMed/7685013" } ] }, { "title": "CD36 is a receptor for oxidized low density lipoprotein.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5686938", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938" } ], "reference": [ { "type": "PubMed", "id": "7685021", "url": "https://glygen.org/publication/PubMed/7685021" } ] }, { "title": "Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting.", "journal": "Experientia", "date": "1993", "authors": "Cianfarani S, Frost VJ, Savage MO, Holly JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "7689487", "url": "https://glygen.org/publication/PubMed/7689487" } ] }, { "title": "B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.", "journal": "Oncogene", "date": "1995", "authors": "Papin C, Eychene A, Brunet A, Pages G, Pouyssegur J, Calothy G, Barnier JV", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "7731720", "url": "https://glygen.org/publication/PubMed/7731720" } ] }, { "title": "Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Seger R, Seger D, Reszka AA, Munar ES, Eldar-Finkelman H, Dobrowolska G, Jensen AM, Campbell JS, Fischer EH, Krebs EG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "7929275", "url": "https://glygen.org/publication/PubMed/7929275" } ] }, { "title": "The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.", "journal": "Molecular and cellular biology", "date": "1994", "authors": "Jaiswal RK, Moodie SA, Wolfman A, Landreth GE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "7935411", "url": "https://glygen.org/publication/PubMed/7935411" } ] }, { "title": "Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.", "journal": "Nature", "date": "1994", "authors": "Schlaepfer DD, Hanks SK, Hunter T, van der Geer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-354194", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354194" } ], "reference": [ { "type": "PubMed", "id": "7997267", "url": "https://glygen.org/publication/PubMed/7997267" } ] }, { "title": "Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli.", "journal": "Clinical and experimental immunology", "date": "1994", "authors": "Pepys MB, Booth SE, Tennent GA, Butler PJ, Williams DG", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8033412", "url": "https://glygen.org/publication/PubMed/8033412" } ] }, { "title": "Cytoplasmic localization of the mitogen-activated protein kinase activator MEK.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Zheng CF, Guan KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "8051079", "url": "https://glygen.org/publication/PubMed/8051079" } ] }, { "title": "Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain.", "journal": "Nature genetics", "date": "1993", "authors": "Benson MD, Liepnieks J, Uemichi T, Wheeler G, Correa R", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8097946", "url": "https://glygen.org/publication/PubMed/8097946" } ] }, { "title": "missing tag=TI", "journal": "missing tag=JT", "date": "missing", "authors": "author information missing", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "81086167", "url": "https://glygen.org/publication/PubMed/81086167" } ] }, { "title": "Structure of pentameric human serum amyloid P component.", "journal": "Nature", "date": "1994", "authors": "Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8114934", "url": "https://glygen.org/publication/PubMed/8114934" } ] }, { "title": "Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin).", "journal": "Blood", "date": "1994", "authors": "Saelman EU, Nieuwenhuis HK, Hese KM, de Groot PG, Heijnen HF, Sage EH, Williams S, McKeown L, Gralnick HR, Sixma JJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8118028", "url": "https://glygen.org/publication/PubMed/8118028" } ] }, { "title": "Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Regan LM, Lamphear BJ, Huggins CF, Walker FJ, Fay PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "8144529", "url": "https://glygen.org/publication/PubMed/8144529" } ] }, { "title": "Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.", "journal": "The EMBO journal", "date": "1994", "authors": "Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "8157000", "url": "https://glygen.org/publication/PubMed/8157000" } ] }, { "title": "Pathogenic potential of human monoclonal immunoglobulin light chains: relationship of in vitro aggregation to in vivo organ deposition.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1994", "authors": "Myatt EA, Westholm FA, Weiss DT, Solomon A, Schiffer M, Stevens FJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8159701", "url": "https://glygen.org/publication/PubMed/8159701" } ] }, { "title": "Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1.", "journal": "European journal of biochemistry", "date": "1993", "authors": "Kern A, Eble J, Golbik R, Kuhn K", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8344274", "url": "https://glygen.org/publication/PubMed/8344274" } ] }, { "title": "Fibrinogen Osaka IV: a congenital dysfibrinogenemia found in a patient originally reported in relation to surgery, now defined to have an A alpha arginine-16 to histidine substitution.", "journal": "Surg. Today", "date": "1993", "authors": "Yamazumi K, Terukina S, Matsuda M, Kanbayashi J, Sakon M, Tsujinaka T", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "8461606", "url": "https://glygen.org/publication/PubMed/8461606" } ] }, { "title": "Human lysozyme gene mutations cause hereditary systemic amyloidosis.", "journal": "Nature", "date": "1993", "authors": "Pepys MB, Hawkins PN, Booth DR, Vigushin DM, Tennent GA, Soutar AK, Totty N, Nguyen O, Blake CC, Terry CJ, et al.", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8464497", "url": "https://glygen.org/publication/PubMed/8464497" } ] }, { "title": "Platelet alpha-granules.", "journal": "Blood reviews", "date": "1993", "authors": "Harrison P, Cramer EM", "evidence": [ { "database": "Reactome", "id": "R-HSA-114608", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608" } ], "reference": [ { "type": "PubMed", "id": "8467233", "url": "https://glygen.org/publication/PubMed/8467233" } ] }, { "title": "Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia.", "journal": "The Journal of clinical investigation", "date": "1993", "authors": "Koopman J, Haverkate F, Grimbergen J, Lord ST, Mosesson MW, DiOrio JP, Siebenlist KS, Legrand C, Soria J, Soria C, et al.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "8473507", "url": "https://glygen.org/publication/PubMed/8473507" } ] }, { "title": "The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease.", "journal": "Biochemistry", "date": "1993", "authors": "Jarrett JT, Berger EP, Lansbury PT Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8490014", "url": "https://glygen.org/publication/PubMed/8490014" } ] }, { "title": "Receptor-ligand interaction between CD44 and osteopontin (Eta-1).", "journal": "Science (New York, N.Y.)", "date": "1996", "authors": "Weber GF, Ashkar S, Glimcher MJ, Cantor H", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8560266", "url": "https://glygen.org/publication/PubMed/8560266" } ] }, { "title": "Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Nakamoto T, Sakai R, Ozawa K, Yazaki Y, Hirai H", "evidence": [ { "database": "Reactome", "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708" } ], "reference": [ { "type": "PubMed", "id": "8621540", "url": "https://glygen.org/publication/PubMed/8621540" } ] }, { "title": "Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Law DA, Nannizzi-Alaimo L, Phillips DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "8631894", "url": "https://glygen.org/publication/PubMed/8631894" } ] }, { "title": "Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Vuori K, Hirai H, Aizawa S, Ruoslahti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-372708", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708" } ], "reference": [ { "type": "PubMed", "id": "8649368", "url": "https://glygen.org/publication/PubMed/8649368" } ] }, { "title": "Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A alpha 20 Val --> Asp).", "journal": "The Journal of clinical investigation", "date": "1995", "authors": "Brennan SO, Hammonds B, George PM", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "8675656", "url": "https://glygen.org/publication/PubMed/8675656" } ] }, { "title": "Not all Shc's roads lead to Ras.", "journal": "Trends in biochemical sciences", "date": "1996", "authors": "Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pelicci PG", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "8755247", "url": "https://glygen.org/publication/PubMed/8755247" } ] }, { "title": "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography.", "journal": "Biochimica et biophysica acta", "date": "1996", "authors": "Bach LA, Rechler MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "8781553", "url": "https://glygen.org/publication/PubMed/8781553" } ] }, { "title": "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Yokosaki Y, Monis H, Chen J, Sheppard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8798654", "url": "https://glygen.org/publication/PubMed/8798654" } ] }, { "title": "Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth.", "journal": "Progress in growth factor research", "date": "1995", "authors": "Rajah R, Katz L, Nunn S, Solberg P, Beers T, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "8817670", "url": "https://glygen.org/publication/PubMed/8817670" } ] }, { "title": "TRAF6 is a signal transducer for interleukin-1.", "journal": "Nature", "date": "1996", "authors": "Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "8837778", "url": "https://glygen.org/publication/PubMed/8837778" } ] }, { "title": "Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1.", "journal": "Journal of cell science", "date": "1996", "authors": "Buckley CD, Doyonnas R, Newton JP, Blystone SD, Brown EJ, Watt SM, Simmons DL", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8838667", "url": "https://glygen.org/publication/PubMed/8838667" } ] }, { "title": "Localized amyloidosis of the seminal vesicle: identification of lactoferrin immunoreactivity in the amyloid material.", "journal": "Pathology international", "date": "1996", "authors": "Tsutsumi Y, Serizawa A, Hori S", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "8870004", "url": "https://glygen.org/publication/PubMed/8870004" } ] }, { "title": "Recombinant human insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases.", "journal": "Growth regulation", "date": "1996", "authors": "Angelloz-Nicoud P, Harel L, Binoux M", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "8894645", "url": "https://glygen.org/publication/PubMed/8894645" } ] }, { "title": "Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Smith LL, Cheung HK, Ling LE, Chen J, Sheppard D, Pytela R, Giachelli CM", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "8910476", "url": "https://glygen.org/publication/PubMed/8910476" } ] }, { "title": "Isolation and characterization of proteolytic fragments of insulin-like growth factor-binding protein-3.", "journal": "Hormone research", "date": "1996", "authors": "Lalou C, Lassarre C, Binoux M", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "8964575", "url": "https://glygen.org/publication/PubMed/8964575" } ] }, { "title": "Prolactin-derived amyloid in the aging pituitary gland.", "journal": "The American journal of pathology", "date": "1997", "authors": "Westermark P, Eriksson L, Engstrom U, Enestrom S, Sletten K", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "9006323", "url": "https://glygen.org/publication/PubMed/9006323" } ] }, { "title": "Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway.", "journal": "Cell", "date": "1997", "authors": "Lee FS, Hagler J, Chen ZJ, Maniatis T", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "9008162", "url": "https://glygen.org/publication/PubMed/9008162" } ] }, { "title": "Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "9020159", "url": "https://glygen.org/publication/PubMed/9020159" } ] }, { "title": "Kerato-epithelin mutations in four 5q31-linked corneal dystrophies.", "journal": "Nature genetics", "date": "1997", "authors": "Munier FL, Korvatska E, Djemai A, Le Paslier D, Zografos L, Pescia G, Schorderet DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "9054935", "url": "https://glygen.org/publication/PubMed/9054935" } ] }, { "title": "missing tag=TI", "journal": "missing tag=JT", "date": "missing", "authors": "author information missing", "evidence": [ { "database": "iPTMnet", "id": "P02671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P02671-1" } ], "reference": [ { "type": "PubMed", "id": "92065884", "url": "https://glygen.org/publication/PubMed/92065884" } ] }, { "title": "Identification of functional endothelial protein C receptor in human plasma.", "journal": "The Journal of clinical investigation", "date": "1997", "authors": "Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT", "evidence": [ { "database": "Reactome", "id": "R-HSA-140875", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875" } ], "reference": [ { "type": "PubMed", "id": "9218519", "url": "https://glygen.org/publication/PubMed/9218519" } ] }, { "title": "The alpha v beta 3 integrin `vitronectin receptor`.", "journal": "The international journal of biochemistry & cell biology", "date": "1997", "authors": "Horton MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9251239", "url": "https://glygen.org/publication/PubMed/9251239" } ] }, { "title": "Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.", "journal": "Nature", "date": "1997", "authors": "Spraggon G, Everse SJ, Doolittle RF", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "9333233", "url": "https://glygen.org/publication/PubMed/9333233" } ] }, { "title": "Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3.", "journal": "The EMBO journal", "date": "1997", "authors": "Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-354192", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192" } ], "reference": [ { "type": "PubMed", "id": "9351824", "url": "https://glygen.org/publication/PubMed/9351824" } ] }, { "title": "Disulfide bridges in NH2-terminal part of human fibrinogen.", "journal": "Thromb. Res.", "date": "1976", "authors": "Blomback B, Hessel B, Hogg D", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "936108", "url": "https://glygen.org/publication/PubMed/936108" } ] }, { "title": "MyD88: an adapter that recruits IRAK to the IL-1 receptor complex.", "journal": "Immunity", "date": "1997", "authors": "Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "9430229", "url": "https://glygen.org/publication/PubMed/9430229" } ] }, { "title": "The alphavbeta5 integrin functions as an endocytic receptor for vitronectin.", "journal": "Journal of cell science", "date": "1998", "authors": "Memmo LM, McKeown-Longo P", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9443892", "url": "https://glygen.org/publication/PubMed/9443892" } ] }, { "title": "Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Twigg SM, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "9497324", "url": "https://glygen.org/publication/PubMed/9497324" } ] }, { "title": "Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, Shigeto N, Chen J, Sheppard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9565552", "url": "https://glygen.org/publication/PubMed/9565552" } ] }, { "title": "Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Schlaepfer DD, Jones KC, Hunter T", "evidence": [ { "database": "Reactome", "id": "R-HSA-354194", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354194" } ], "reference": [ { "type": "PubMed", "id": "9566877", "url": "https://glygen.org/publication/PubMed/9566877" } ] }, { "title": "Crystal structure of fragment double-D from human fibrin with two different bound ligands.", "journal": "Biochemistry", "date": "1998", "authors": "Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle RF", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "9628725", "url": "https://glygen.org/publication/PubMed/9628725" } ] }, { "title": "Crystal structure of a recombinant alphaEC domain from human fibrinogen-420.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Spraggon G, Applegate D, Everse SJ, Zhang JZ, Veerapandian L, Redman C, Doolittle RF, Grieninger G", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671#ptm_processing" }, { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "reference": [ { "type": "PubMed", "id": "9689040", "url": "https://glygen.org/publication/PubMed/9689040" } ] }, { "title": "Identification of novel high molecular weight insulin-like growth factor-binding protein-3 association proteins in human serum.", "journal": "The Journal of clinical endocrinology and metabolism", "date": "1998", "authors": "Collett-Solberg PF, Nunn SE, Gibson TB, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "9709957", "url": "https://glygen.org/publication/PubMed/9709957" } ] }, { "title": "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.", "journal": "Science (New York, N.Y.)", "date": "1998", "authors": "Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "9733512", "url": "https://glygen.org/publication/PubMed/9733512" } ] }, { "title": "The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Jansson M, Andersson G, Uhlen M, Nilsson B, Kordel J", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "9733769", "url": "https://glygen.org/publication/PubMed/9733769" } ] }, { "title": "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Twigg SM, Kiefer MC, Zapf J, Baxter RC", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "9786878", "url": "https://glygen.org/publication/PubMed/9786878" } ] }, { "title": "Effect of the interaction between fibronectin and VLA-4 on the proliferation of human B cells, especially a novel human B-cell line, OPM-3.", "journal": "British journal of haematology", "date": "1998", "authors": "Yoshida H, Nishiura T, Karasuno T, Matsumura I, Ishikawa J, Yoshimura M, Yokota T, Okajima Y, Ogawa M, Kanakura Y, Tomiyama Y, Matsuzawa Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-216083", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083" } ], "reference": [ { "type": "PubMed", "id": "9858236", "url": "https://glygen.org/publication/PubMed/9858236" } ] }, { "title": "Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Cacace AM, Michaud NR, Therrien M, Mathes K, Copeland T, Rubin GM, Morrison DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5674135", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135" } ], "reference": [ { "type": "PubMed", "id": "9858547", "url": "https://glygen.org/publication/PubMed/9858547" } ] }, { "title": "Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.", "journal": "FEBS letters", "date": "1998", "authors": "El-Agnaf OM, Jakes R, Curran MD, Wallace A", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "9862427", "url": "https://glygen.org/publication/PubMed/9862427" } ] }, { "title": "Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.", "journal": "American journal of respiratory cell and molecular biology", "date": "1999", "authors": "Rajah R, Nachajon RV, Collins MH, Hakonarson H, Grunstein MM, Cohen P", "evidence": [ { "database": "Reactome", "id": "R-HSA-381426", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426" } ], "reference": [ { "type": "PubMed", "id": "9922210", "url": "https://glygen.org/publication/PubMed/9922210" } ] } ], "pathway": [ { "id": "hsa:2243", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:2243", "resource": "KEGG Pathway" }, { "id": "R-HSA-114608", "name": "Platelet degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114608", "resource": "Reactome", "description": "Platelet degranulation" }, { "id": "R-HSA-1236974", "name": "ER-Phagosome pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1236974", "resource": "Reactome", "description": "ER-Phagosome pathway" }, { "id": "R-HSA-140875", "name": "Common Pathway of Fibrin Clot Formation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-140875", "resource": "Reactome", "description": "Common Pathway of Fibrin Clot Formation" }, { "id": "R-HSA-166058", "name": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058", "resource": "Reactome", "description": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane" }, { "id": "R-HSA-216083", "name": "Integrin cell surface interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-216083", "resource": "Reactome", "description": "Integrin cell surface interactions" }, { "id": "R-HSA-354192", "name": "Integrin signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354192", "resource": "Reactome", "description": "Integrin signaling" }, { "id": "R-HSA-354194", "name": "GRB2:SOS provides linkage to MAPK signaling for Integrins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-354194", "resource": "Reactome", "description": "GRB2:SOS provides linkage to MAPK signaling for Integrins" }, { "id": "R-HSA-372708", "name": "p130Cas linkage to MAPK signaling for integrins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-372708", "resource": "Reactome", "description": "p130Cas linkage to MAPK signaling for integrins" }, { "id": "R-HSA-381426", "name": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426", "resource": "Reactome", "description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)" }, { "id": "R-HSA-5602498", "name": "MyD88 deficiency (TLR2/4)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5602498", "resource": "Reactome", "description": "MyD88 deficiency (TLR2/4)" }, { "id": "R-HSA-5603041", "name": "IRAK4 deficiency (TLR2/4)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5603041", "resource": "Reactome", "description": "IRAK4 deficiency (TLR2/4)" }, { "id": "R-HSA-5674135", "name": "MAP2K and MAPK activation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135", "resource": "Reactome", "description": "MAP2K and MAPK activation" }, { "id": "R-HSA-5686938", "name": "Regulation of TLR by endogenous ligand", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686938", "resource": "Reactome", "description": "Regulation of TLR by endogenous ligand" }, { "id": "R-HSA-6802946", "name": "Signaling by moderate kinase activity BRAF mutants", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946", "resource": "Reactome", "description": "Signaling by moderate kinase activity BRAF mutants" }, { "id": "R-HSA-6802948", "name": "Signaling by high-kinase activity BRAF mutants", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948", "resource": "Reactome", "description": "Signaling by high-kinase activity BRAF mutants" }, { "id": "R-HSA-6802952", "name": "Signaling by BRAF and RAF1 fusions", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952", "resource": "Reactome", "description": "Signaling by BRAF and RAF1 fusions" }, { "id": "R-HSA-6802955", "name": "Paradoxical activation of RAF signaling by kinase inactive BRAF", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955", "resource": "Reactome", "description": "Paradoxical activation of RAF signaling by kinase inactive BRAF" }, { "id": "R-HSA-8957275", "name": "Post-translational protein phosphorylation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8957275", "resource": "Reactome", "description": "Post-translational protein phosphorylation" }, { "id": "R-HSA-9649948", "name": "Signaling downstream of RAS mutants", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948", "resource": "Reactome", "description": "Signaling downstream of RAS mutants" }, { "id": "R-HSA-9656223", "name": "Signaling by RAF1 mutants", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223", "resource": "Reactome", "description": "Signaling by RAF1 mutants" }, { "id": "R-HSA-977225", "name": "Amyloid fiber formation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225", "resource": "Reactome", "description": "Amyloid fiber formation" } ], "orthologs": [ { "uniprot_canonical_ac": "E9PV24-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "Fga", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLSLRVTCLILSVASTVWTTDTEDKGEFLSEGGGVRGPRVVERHQSQCKDSDWPFCSDDDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQRNNKDSNSLTRNIMEYLRGDFANANNFDNTYGQVSEDLRRRIEILRRKVIEKAQQIQALQSNVRAQLIDMKRLEVDIDIKIRSCKGSCSRAVNREINLQDYEGHQKQLQQVIAKELLPTKDRQYLPALKMSPVPDLVPGSFKSQLQEAPPEWKALTEMRQMRMELERPGKDGGSRGDSPGDSRGDSRGDFATRGPGSKAENPTNPGPGGSGYWRPGNSGSGSDGNRNPGTTGSDGTGDWGTGSPRPGSDSGNFRPANPNWGVFSEFGDSSSPATRKEYHTGKAVTSKGDKELLIGKEKVTSSGTSTTHRSCSKTITKTVTGPDGRREVVKEVITSDDGSDCGDATELDISHSFSGSLDELSERHPDLSGFFDNHFGLISPNFKEFGSKTHSDSDILTNIEDPSSHVPEFSSSSKTSTVKKQVTKTYKMADEAGSEAHREGETRNTKRGRARARPTRDCDDVLQTQTSGAQNGIFSIKPPGSSKVFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDKGEGEFWLGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYRGTAGDALVQGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPGGTYDPRNNSPYEIENGVVWVPFRGADYSLRAVRMKIRPLVGQ", "length": 789 }, "evidence": [ { "id": "45918301", "url": "http://www.informatics.jax.org/homology/45918301", "database": "MGI" }, { "id": "P02671", "url": "https://omabrowser.org/oma/group/P02671/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P06399-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "Fga", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLSLRVACLILSLASTVWTADTGTTSEFIEAGGDIRGPRIVERQPSQCKETDWPFCSDEDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQKNNKDSNSLTRNIMEYLRGDFANANNFDNTFGQVSEDLRRRIQILKRKVIEKAQQIQVLQKDVRDQLIDMKRLEVDIDIKIRSCKGSCSRSVSREINLKDYEGQQKQLEQVIAKDLLPAKDRQYLPAIKMSPVPDLVPGSFKSQLQEGPPEWKALTEMRQMRMELERPGKDGASRGDLPGDSRGDSATRGPGSKIENPMTPGHGGSGYWRPGSSGSGSDGNWGSGTTGSDDTGTWGAGSSRPSSGSGNLKPSNPDWGEFSEFGGSSSPATRKEYHTGKLVTSKGDKELLIGNEKVTSTGTSTTRRSCSKTITKTVLGNDGHREVVKEVVTSDDGSDCGDGMDLGLTHSFSGRLDELSRMHPELGSFYDSRFGSLTSNFKEFGSKTSDSDIFTDIENPSSHVPEFSSSSKTSTVRKQVTKSYKMADEAASEAHQEGDTRTTKRGRARTMRDCDDVLQTHPSGAQNGIFSIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDKGEGEFWLGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYQGTAGDALMEGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPGGTYDPRNNSPYEIENGVLWVPFRGADYSLWAVRMKIRPLVGQ", "length": 782 }, "evidence": [ { "id": "45918301", "url": "http://www.informatics.jax.org/homology/45918301", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "structural molecule activity", "id": "GO:0005198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "extracellular matrix structural constituent", "id": "GO:0005201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005201", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 14, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "platelet alpha granule lumen", "id": "GO:0031093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031093", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "blood microparticle", "id": "GO:0072562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072562", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "external side of plasma membrane", "id": "GO:0009897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "fibrinogen complex", "id": "GO:0005577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005577", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "extracellular vesicle", "id": "GO:1903561", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903561", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "platelet alpha granule", "id": "GO:0031091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031091", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "innate immune response", "id": "GO:0045087", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "response to calcium ion", "id": "GO:0051592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051592", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of protein secretion", "id": "GO:0050714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050714", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "fibrinolysis", "id": "GO:0042730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042730", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of vasoconstriction", "id": "GO:0045907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045907", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "negative regulation of endothelial cell apoptotic process", "id": "GO:2000352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000352", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "platelet aggregation", "id": "GO:0070527", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070527", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "plasminogen activation", "id": "GO:0031639", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031639", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway via death domain receptors", "id": "GO:1902042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902042", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "protein polymerization", "id": "GO:0051258", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051258", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "blood coagulation, common pathway", "id": "GO:0072377", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072377", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of peptide hormone secretion", "id": "GO:0090277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090277", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "induction of bacterial agglutination", "id": "GO:0043152", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043152", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of heterotypic cell-cell adhesion", "id": "GO:0034116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034116", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "positive regulation of exocytosis", "id": "GO:0045921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045921", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "blood coagulation, fibrin clot formation", "id": "GO:0072378", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072378", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" }, { "name": "protein-containing complex assembly", "id": "GO:0065003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0065003", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "fibrinogen alpha chain O-glycosylated 1 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-297 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G73004SD. Example: UniProtKB:P02671-1, Ser-297, MOD:00002~GNO:G73004SD. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052507", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052507" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 2 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-338 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-338, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052508", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052508" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 3 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-351 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P02671-1, Ser-351, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052509", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052509" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 4 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-351 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-351, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052510", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052510" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 5 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-375 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-375, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052511", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052511" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 6 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-397 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-397, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052512", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052512" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 7 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-501 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-501, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052513", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052513" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 8 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-524 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G17015OC. Example: UniProtKB:P02671-1, Ser-524, MOD:00002~GNO:G17015OC. [PRO:DNx, PMID:26598643]", "evidence": [ { "id": "PR:000052514", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052514" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 9 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-534 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-534, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052515", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052515" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 10 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-546 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-546, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052516", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052516" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 11 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-549 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-549, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052517", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052517" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 12 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-562 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P02671-1, Ser-562, MOD:00002~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052518", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052518" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 13 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Ser-562 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Ser-562, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052519", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052519" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 14 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-315 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-315, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052520", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052520" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 15 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-318 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-318, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052521", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052521" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 16 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-320 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-320, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052522", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052522" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 17 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-341 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-341, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052523", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052523" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 18 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-357 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-357, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052524", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052524" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 19 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-359 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-359, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052525", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052525" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 20 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-499 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P02671-1, Thr-499, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052526", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052526" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 21 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-499 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-499, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052527", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052527" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 22 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-525 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G17015OC. Example: UniProtKB:P02671-1, Thr-525, MOD:00005~GNO:G17015OC. [PRO:DNx, PMID:26598643]", "evidence": [ { "id": "PR:000052528", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052528" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 23 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-528 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G17015OC. Example: UniProtKB:P02671-1, Thr-528, MOD:00005~GNO:G17015OC. [PRO:DNx, PMID:26598643, PMID:30459171]", "evidence": [ { "id": "PR:000052529", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052529" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 24 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-528 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-528, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:26598643, PMID:30459171]", "evidence": [ { "id": "PR:000052530", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052530" } ] }, { "name": "fibrinogen alpha chain O-glycosylated 25 (human)", "definition": "A fibrinogen alpha chain (human) that has been O-glycosylated at the residue equivalent to Thr-557 of the amino acid sequence represented by UniProtKB:P02671-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P02671-1, Thr-557, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000052531", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052531" } ] } ], "site_annotation": [ { "start_pos": 419, "end_pos": 421, "annotation": "n_glycosylation_sequon" }, { "start_pos": 686, "end_pos": 688, "annotation": "n_glycosylation_sequon" }, { "start_pos": 831, "end_pos": 833, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "2143188", "url": "https://glygen.org/publication/PubMed/2143188" } ] }, { "annotation": "O-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "23050552", "url": "https://glygen.org/publication/PubMed/23050552" } ] }, { "annotation": "Phosphorylated by FAM20C in the extracellular medium.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ] }, { "annotation": "The alpha chain is normally not N-glycosylated (PubMed:23151259), even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells (PubMed:9689040). It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies (PubMed:16335952, PubMed:19159218), but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency.", "evidence": [ { "database": "UniProtKB", "id": "P02671", "url": "https://www.uniprot.org/uniprot/P02671" }, { "database": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" }, { "database": "PubMed", "id": "16335952", "url": "https://glygen.org/publication/PubMed/16335952" }, { "database": "PubMed", "id": "23151259", "url": "https://glygen.org/publication/PubMed/23151259" }, { "database": "PubMed", "id": "9689040", "url": "https://glygen.org/publication/PubMed/9689040" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 684, 686 ], "o_linked_sites": [ 98, 101, 107, 250, 252, 272, 283, 297, 315, 318, 320, 338, 341, 351, 357, 359, 375, 397, 499, 501, 511, 524, 525, 528, 534, 546, 549, 557, 559, 562, 582, 586, 603, 616 ], "snv_sites": [ 110, 116, 283, 297, 315, 338, 341, 348, 351, 357, 408, 453, 524, 546, 557, 562, 586, 616, 688, 783, 818 ], "glycation_sites": [], "phosphorylation_sites": [ 22, 45, 50, 56, 277, 281, 291, 294, 356, 364, 365, 412, 451, 460, 501, 505, 524, 549, 560, 576, 577, 578, 609, 618 ], "sequon_annotation_sites": [ { "start_pos": 419, "end_pos": 421 }, { "start_pos": 686, "end_pos": 688 }, { "start_pos": 831, "end_pos": 833 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 55 }, { "field": "total_sites", "count": 29 }, { "field": "n_linked_glycans", "count": 10 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 5 }, { "field": "o_linked_glycan_sites", "count": 29 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 51 }, { "field": "total_sites", "count": 28 }, { "field": "n_linked_glycans", "count": 10 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 5 }, { "field": "o_linked_glycan_sites", "count": 27 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 24 }, { "field": "total_sites", "count": 24 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 27 }, { "field": "total_sites", "count": 21 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 26 }, { "field": "total_sites", "count": 20 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 485 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }