{ "uniprot_canonical_ac": "P01903-1", "uniprot_ac": "P01903", "uniprot_id": "DRA_HUMAN", "mass": { "chemical_mass": 28621.0, "monoisotopic_mass": 28621.0 }, "refseq": { "ac": "NP_061984", "name": "HLA class II histocompatibility antigen, DR alpha chain precursor", "summary": "HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" }, "gene_names": [ { "name": "HLA-DRA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P01903", "id": "P01903" }, { "name": "HLA-DRA1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984", "id": "NP_061984" }, { "name": "HLA-DRA1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P01903", "id": "P01903" }, { "name": "HLA-DRA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984", "id": "NP_061984" } ], "protein_names": [ { "name": "HLA class II histocompatibility antigen, DR alpha chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P01903" }, { "name": "HLA class II histocompatibility antigen, DR alpha chain precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984", "id": "NP_061984" }, { "name": "HLA class II histocompatibility antigen, DR alpha chain; histocompatibility antigen HLA-DR alpha; MHC class II antigen DRA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984", "id": "NP_061984" }, { "name": "MHC class II antigen DRA", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01903" } ], "function": [ { "annotation": "An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819).", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903#function" }, { "database": "PubMed", "id": "29884618", "url": "https://glygen.org/publication/PubMed/29884618" }, { "database": "PubMed", "id": "25413013", "url": "https://glygen.org/publication/PubMed/25413013" }, { "database": "PubMed", "id": "9075930", "url": "https://glygen.org/publication/PubMed/9075930" }, { "database": "PubMed", "id": "17334368", "url": "https://glygen.org/publication/PubMed/17334368" }, { "database": "PubMed", "id": "15322540", "url": "https://glygen.org/publication/PubMed/15322540" }, { "database": "PubMed", "id": "8145819", "url": "https://glygen.org/publication/PubMed/8145819" }, { "database": "PubMed", "id": "24190431", "url": "https://glygen.org/publication/PubMed/24190431" }, { "database": "PubMed", "id": "17182262", "url": "https://glygen.org/publication/PubMed/17182262" }, { "database": "PubMed", "id": "22327072", "url": "https://glygen.org/publication/PubMed/22327072" }, { "database": "PubMed", "id": "31495665", "url": "https://glygen.org/publication/PubMed/31495665" }, { "database": "PubMed", "id": "15265931", "url": "https://glygen.org/publication/PubMed/15265931" }, { "database": "PubMed", "id": "23783831", "url": "https://glygen.org/publication/PubMed/23783831" }, { "database": "PubMed", "id": "27591323", "url": "https://glygen.org/publication/PubMed/27591323" } ] }, { "annotation": "Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" }, { "database": "PubMed", "id": "34858413", "url": "https://glygen.org/publication/PubMed/34858413" } ] }, { "annotation": "Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" }, { "database": "PubMed", "id": "35543859", "url": "https://glygen.org/publication/PubMed/35543859" } ] }, { "annotation": "Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis development in the Korean population.", "evidence": [ { "database": "RefSeq", "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" }, { "database": "PubMed", "id": "35895219", "url": "https://glygen.org/publication/PubMed/35895219" } ] }, { "annotation": "HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" }, { "database": "PubMed", "id": "35794593", "url": "https://glygen.org/publication/PubMed/35794593" } ] }, { "annotation": "HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. This molecule is expressed on the surface of various antigen presenting cells such as B lymphocytes, dendritic cells, and monocytes/macrophages, and plays a central role in the immune system and response by presenting peptides derived from extracellular proteins, in particular, pathogen-derived peptides to T cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020].", "evidence": [ { "database": "RefSeq", "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" } ] }, { "annotation": "Identification of three novel HLA-DRA alleles by next-generation sequencing.", "evidence": [ { "database": "RefSeq", "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984" }, { "database": "PubMed", "id": "34402606", "url": "https://glygen.org/publication/PubMed/34402606" } ] } ], "disease": [ { "disease_id": "MONDO:0012488", "recommended_name": { "id": "MONDO:0012488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012488", "name": "hepatitis B virus, susceptibility to", "description": "" }, "synonyms": [ { "id": "MONDO:0012488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012488", "name": "hepatitis B virus infection, susceptibility to", "description": "" }, { "id": "MONDO:0012488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012488", "name": "hepatitis b virus, susceptibility to", "description": "" }, { "id": "MONDO:0012488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012488", "name": "HBV, resistance to", "description": "" }, { "id": "MONDO:0012488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012488", "name": "HBV, susceptibility to", "description": "" }, { "id": "MONDO:0012488", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012488", "name": "Hepatitis B Virus, resistance to", "description": "" } ], "evidence": [ { "id": "610424", "database": "MIM", "url": "https://www.omim.org/entry/610424" } ] } ], "snv": [ { "evidence": [ { "id": "rs1450907470", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1450907470" }, { "id": "rs1450907470", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1450907470#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 103, "end_pos": 103, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->SYT).", "chr_id": "6", "chr_pos": "32442673", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N103", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs983382248", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs983382248" }, { "id": "rs983382248", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs983382248#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 105, "end_pos": 105, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->NYI).", "chr_id": "6", "chr_pos": "32442679", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T105", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1422162225", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1422162225" }, { "id": "rs1422162225", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1422162225" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 145, "end_pos": 145, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->NVA).", "chr_id": "6", "chr_pos": "32443289", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T145", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs946681808", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs946681808" }, { "id": "rs946681808", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs946681808" }, { "id": "rs946681808", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs946681808" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 145, "end_pos": 145, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->NVM).", "chr_id": "6", "chr_pos": "32443290", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T145", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1484267377", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1484267377" }, { "id": "rs1484267377", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1484267377" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 248, "end_pos": 248, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAA->NAT).", "chr_id": "6", "chr_pos": "32443887", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A248", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760911515", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760911515" }, { "id": "rs760911515", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760911515" }, { "id": "rs760911515", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760911515" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 42, "end_pos": 42, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DQS->NQS).", "chr_id": "6", "chr_pos": "32442489", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D42", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 115, "end_pos": 115, "sequence_org": "T", "sequence_mut": "R", "comment": "Decreases the interaction with CD4.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "27114505", "url": "https://glygen.org/publication/PubMed/27114505" } ] }, { "start_pos": 117, "end_pos": 117, "sequence_org": "L", "sequence_mut": "R", "comment": "Decreases the interaction with CD4.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "27114505", "url": "https://glygen.org/publication/PubMed/27114505" } ] }, { "start_pos": 121, "end_pos": 121, "sequence_org": "P", "sequence_mut": "S", "comment": "Decreases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 125, "end_pos": 125, "sequence_org": "R", "sequence_mut": "A", "comment": "Impairs the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 244, "end_pos": 244, "sequence_org": "K", "sequence_mut": "R", "comment": "Almost no change in down-regulation of MHCII. No ubiquitination and complete loss of down-regulation of MHCII; when associated with 'R-254' of HLA-DRB.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "19117940", "url": "https://glygen.org/publication/PubMed/19117940" } ] }, { "start_pos": 65, "end_pos": 65, "sequence_org": "E", "sequence_mut": "K", "comment": "Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "11070170", "url": "https://glygen.org/publication/PubMed/11070170" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 68, "end_pos": 68, "sequence_org": "W", "sequence_mut": "F", "comment": "Decreases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 74, "end_pos": 74, "sequence_org": "G", "sequence_mut": "S", "comment": "Increases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 76, "end_pos": 76, "sequence_org": "F", "sequence_mut": "A", "comment": "Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "11070170", "url": "https://glygen.org/publication/PubMed/11070170" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 76, "end_pos": 76, "sequence_org": "F", "sequence_mut": "L", "comment": "Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "11070170", "url": "https://glygen.org/publication/PubMed/11070170" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 76, "end_pos": 76, "sequence_org": "F", "sequence_mut": "S", "comment": "Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "11070170", "url": "https://glygen.org/publication/PubMed/11070170" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 76, "end_pos": 76, "sequence_org": "F", "sequence_mut": "V", "comment": "Impairs the interaction with HLA-DM complex, CLIP dissociation and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "11070170", "url": "https://glygen.org/publication/PubMed/11070170" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 76, "end_pos": 76, "sequence_org": "F", "sequence_mut": "W", "comment": "Increases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 78, "end_pos": 78, "sequence_org": "S", "sequence_mut": "D", "comment": "Decreases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 78, "end_pos": 78, "sequence_org": "S", "sequence_mut": "H", "comment": "Decreases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 79, "end_pos": 79, "sequence_org": "F", "sequence_mut": "A", "comment": "Increases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 79, "end_pos": 79, "sequence_org": "F", "sequence_mut": "C", "comment": "Increases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 80, "end_pos": 80, "sequence_org": "E", "sequence_mut": "A", "comment": "Increases the interaction with HLA-DM complex and peptide exchange. Decreases the affinity of the interaction with TCR by more than five-fold.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "29884618", "url": "https://glygen.org/publication/PubMed/29884618" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 82, "end_pos": 82, "sequence_org": "Q", "sequence_mut": "A", "comment": "Decreases the interaction with HLA-DM complex and peptide exchange.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "23260142", "url": "https://glygen.org/publication/PubMed/23260142" } ] }, { "start_pos": 93, "end_pos": 93, "sequence_org": "A", "sequence_mut": "L", "comment": "Decreases the affinity of the interaction with TCR by more than five-fold.", "evidence": [ { "database": "UniProtKB", "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903" }, { "database": "PubMed", "id": "29884618", "url": "https://glygen.org/publication/PubMed/29884618" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "96.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204287", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204287" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "98.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204287", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204287" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "99.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01903" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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Classification" ] }, { "id": "R-HSA-389948", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-389948", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-877300", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-877300", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_061984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061984", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P01903", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "A0A0G2JH46", "url": "https://www.uniprot.org/uniprot/A0A0G2JH46", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JH46-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JH46-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JMH6", "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JMH6-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JMH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P01903", "url": "https://www.uniprot.org/uniprot/P01903", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P01903-1", "url": "https://www.uniprot.org/uniprot/P01903-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q30118", "url": "https://www.uniprot.org/uniprot/Q30118", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q30118-1", "url": "https://www.uniprot.org/uniprot/Q30118-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL", "length": 254, "header": "sp|P01903-1|DRA_HUMAN Isoform 1 of HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2 CANONICAL=P01903-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JH46-1", "url": "", "sequence": { "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGVRKSNAAERRGPL", "length": 229, "header": "tr|A0A0G2JH46-1|DRA_HUMAN Computationally mapped isoform of HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=1 CANONICAL=P01903-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 3784871, "end_pos": 3780917, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000418111.2", "url": "https://www.ensembl.org/id/ENST00000418111.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000412562.2", "url": "https://www.ensembl.org/id/ENSP00000412562.2" } ] } }, { "isoform_ac": "A0A0G2JMH6-1", "url": "", "sequence": { "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL", "length": 254, "header": "tr|A0A0G2JMH6-1|DRA_HUMAN Computationally mapped isoform of HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=1 CANONICAL=P01903-1" }, "locus": { "chromosome": "HSCHR6_8_CTG1", "start_pos": 14782, "end_pos": 10826, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000613328", "url": "https://www.ensembl.org/id/ENST00000613328" }, { "database": "Ensembl Peptide", "id": "ENSP00000479287", "url": "https://www.ensembl.org/id/ENSP00000479287" } ] } }, { "isoform_ac": "P01903-1", "url": "", "sequence": { "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL", "length": 254, "header": "sp|P01903-1|DRA_HUMAN Isoform 1 of HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2 CANONICAL=P01903-1" }, "locus": { "chromosome": "HSCHR6_MHC_COX_CTG1", "start_pos": 3882030, "end_pos": 3878077, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000383127.6", "url": "https://www.ensembl.org/id/ENST00000383127.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000372608.2", "url": "https://www.ensembl.org/id/ENSP00000372608.2" } ] } }, { "isoform_ac": "Q30118-1", "url": "", "sequence": { "sequence": "MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL", "length": 229, "header": "tr|Q30118-1|Q30118_HUMAN Computationally mapped isoform of HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=1 CANONICAL=P01903-1" }, "locus": { "chromosome": "6", "start_pos": 32443907, "end_pos": 32439951, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374982.5", "url": "https://www.ensembl.org/id/ENST00000374982.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000364121.5", "url": "https://www.ensembl.org/id/ENSP00000364121.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G11870QZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 103, "start_aa": 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