{ "uniprot_canonical_ac": "P01859-2", "uniprot_ac": "P01859", "uniprot_id": "IGHG2_HUMAN", "mass": { "chemical_mass": 43806.0, "monoisotopic_mass": 43806.0 }, "refseq": {}, "gene_names": [ { "name": "IGHG2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P01859", "id": "P01859" } ], "protein_names": [ { "name": "Immunoglobulin heavy constant gamma 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P01859" }, { "name": "Ig gamma-2 chain C region DOT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01859" }, { "name": "Ig gamma-2 chain C region TIL", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01859" }, { "name": "Ig gamma-2 chain C region ZIE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01859" }, { "name": "Ig gamma-2 chain C region", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01859" } ], "function": [ { "annotation": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. 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"" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P01859", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01859" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "P01859", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01859" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", 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"id": "R-HSA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029482" } ], "reference": [ { "type": "PubMed", "id": "9843499", "url": "https://glygen.org/publication/PubMed/9843499" } ] }, { "title": "Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Lupher ML Jr, Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA, Druker B, Band H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323" } ], "reference": [ { "type": "PubMed", "id": "9857068", "url": "https://glygen.org/publication/PubMed/9857068" } ] }, { "title": "EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family.", "journal": "FEBS letters", "date": "1998", "authors": "Callebaut I, Cossart P, Dehoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029482" } ], "reference": [ { "type": "PubMed", "id": "9883880", "url": "https://glygen.org/publication/PubMed/9883880" } ] }, { "title": "A contractile activity that closes phagosomes in macrophages.", "journal": "Journal of cell science", "date": "1999", "authors": "Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029482" } ], "reference": [ { "type": "PubMed", "id": "9885284", "url": "https://glygen.org/publication/PubMed/9885284" } ] }, { "title": "Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1999", "authors": "Kusner DJ, Hall CF, Jackson S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "9973503", "url": "https://glygen.org/publication/PubMed/9973503" } ] } ], "pathway": [ { "id": "R-HSA-166663", "name": "Initial triggering of complement", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166663", "resource": "Reactome", "description": "Initial triggering of complement" }, { "id": "R-HSA-173623", "name": "Classical antibody-mediated complement activation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-173623", "resource": "Reactome", "description": "Classical antibody-mediated complement activation" }, { "id": "R-HSA-2029481", "name": "FCGR activation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029481", "resource": "Reactome", "description": "FCGR activation" }, { "id": "R-HSA-2029482", "name": "Regulation of actin dynamics for phagocytic cup formation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029482", "resource": "Reactome", "description": "Regulation of actin dynamics for phagocytic cup formation" }, { "id": "R-HSA-2029485", "name": "Role of phospholipids in phagocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485", "resource": "Reactome", "description": "Role of phospholipids in phagocytosis" }, { "id": "R-HSA-9664323", "name": "FCGR3A-mediated IL10 synthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323", "resource": "Reactome", "description": "FCGR3A-mediated IL10 synthesis" }, { "id": "R-HSA-9664422", "name": "FCGR3A-mediated phagocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422", "resource": "Reactome", "description": "FCGR3A-mediated phagocytosis" }, { "id": "R-HSA-977606", "name": "Regulation of Complement cascade", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977606", "resource": "Reactome", "description": "Regulation of Complement cascade" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "immunoglobulin receptor binding", "id": "GO:0034987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034987", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "antigen binding", "id": "GO:0003823", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003823", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "blood microparticle", "id": "GO:0072562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072562", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "immunoglobulin complex, circulating", "id": "GO:0042571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042571", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "IgG immunoglobulin complex", "id": "GO:0071735", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071735", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "antibacterial humoral response", "id": "GO:0019731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019731", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "adaptive immune response", "id": "GO:0002250", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002250", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "B cell receptor signaling pathway", "id": "GO:0050853", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" }, { "name": "complement activation, classical pathway", "id": "GO:0006958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 1 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G01650EU. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G01650EU. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052129", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052129" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 2 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:21609021, PMID:24766575, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000052130", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052130" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 3 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G11254FL. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G11254FL. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052131", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052131" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 4 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G12580WI. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G12580WI. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052132", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052132" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 5 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G22674CI. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G22674CI. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052133", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052133" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 6 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G25520XG. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G25520XG. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052134", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052134" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 7 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G25987BV. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G25987BV. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052135", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052135" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 8 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G28681TP. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G28681TP. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052136", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052136" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 9 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G30159WR. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G30159WR. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052137", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052137" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 10 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G36191CD. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052138", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052138" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 11 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G36670VW. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G36670VW. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052139", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052139" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 12 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G39213VZ. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G39213VZ. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052140", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052140" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 13 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G54600FO. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G54600FO. [PRO:DNx, PMID:21609021, PMID:24766575, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000052141", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052141" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 14 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G54992WG. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G54992WG. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052142", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052142" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 15 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052143", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052143" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 16 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G59937CP. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G59937CP. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052144", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052144" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 17 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G67324HN. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G67324HN. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052145", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052145" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 18 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G68318VE. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G68318VE. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052146", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052146" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 19 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G72791KH. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G72791KH. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052147", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052147" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 20 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G78059CC. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052148", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052148" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 21 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan structure is represented by GlyTouCan:G80858MF. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G80858MF. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052149", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052149" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 22 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G83555HU. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052150", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052150" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 23 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052151", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052151" } ] }, { "name": "immunoglobulin heavy constant gamma 2 N-glycosylated 24 (human)", "definition": "An immunoglobulin heavy constant gamma 2 (human) that has been N-glycosylated at the residue equivalent to Asn-176 of the amino acid sequence represented by UniProtKB:P01859-1, in which the glycan composition is represented by GlyTouCan:G88725PI. Example: UniProtKB:P01859-1, Asn-176, MOD:00160~GNO:G88725PI. [PRO:DNx, PMID:21609021, PMID:29671580]", "evidence": [ { "id": "PR:000052152", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052152" } ] } ], "site_annotation": [ { "start_pos": 176, "end_pos": 178, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "(Microbial infection) Deglycosylation on Asn-176 by S.pyogenes EndoS or Endos2 endoglucosidases prevents interaction between immunoglobulin-gamma (IgG) and Fc receptors, impairing ability to activate the complement pathway.", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" }, { "database": "PubMed", "id": "11406581", "url": "https://glygen.org/publication/PubMed/11406581" }, { "database": "PubMed", "id": "23865566", "url": "https://glygen.org/publication/PubMed/23865566" }, { "database": "PubMed", "id": "20357243", "url": "https://glygen.org/publication/PubMed/20357243" } ] }, { "annotation": "Glycosylation on Asn-176 is required for interaction with Fc receptors and ability to activate the complement pathway.", "evidence": [ { "database": "UniProtKB", "id": "P01859", "url": "https://www.uniprot.org/uniprot/P01859" }, { "database": "PubMed", "id": "20357243", "url": "https://glygen.org/publication/PubMed/20357243" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [ 176 ], "o_linked_sites": [], "snv_sites": [ 17, 77, 78, 93, 176, 178, 206, 255, 271, 280 ], "glycation_sites": [], "phosphorylation_sites": [ 305 ], "sequon_annotation_sites": [ { "start_pos": 176, "end_pos": 178 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 214 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 151 }, { "field": "n_linked_glycan_sites", 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