{ "uniprot_canonical_ac": "P01857-2", "uniprot_ac": "P01857", "uniprot_id": "IGHG1_HUMAN", "mass": { "chemical_mass": 43912.0, "monoisotopic_mass": 43912.0 }, "refseq": {}, "gene_names": [ { "name": "IGHG1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P01857", "id": "P01857" } ], "protein_names": [ { "name": "Immunoglobulin heavy constant gamma 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P01857" }, { "name": "Ig gamma-1 chain C region EU", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01857" }, { "name": "Ig gamma-1 chain C region KOL", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01857" }, { "name": "Ig gamma-1 chain C region NIE", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01857" }, { "name": "Ig gamma-1 chain C region", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01857" } ], "function": [ { "annotation": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857#function" }, { "database": "PubMed", "id": "20176268", "url": "https://glygen.org/publication/PubMed/20176268" }, { "database": "PubMed", "id": "22158414", "url": "https://glygen.org/publication/PubMed/22158414" }, { "database": "PubMed", "id": "17576170", "url": "https://glygen.org/publication/PubMed/17576170" }, { "database": "PubMed", "id": "11711607", "url": "https://glygen.org/publication/PubMed/11711607" } ] } ], "disease": [ { "disease_id": "DOID:9538", "recommended_name": { "id": "DOID:9538", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9538", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow." }, "synonyms": [ { "id": "DOID:9538", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9538", "name": "myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloma", "description": "A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Kahler disease", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Kahler's disease", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "medullary plasmacytoma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma, resistance to, Somatic mutation", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma, susceptibility to, Somatic mutation", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "multiple myeloma/plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloid neoplasm of plasma cell", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma, multiple", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma, plasma cell, malignant", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myelomatosis", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloid neoplasm", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "Al amyloidosis", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "amyloidosis, systemic", "description": "" }, { "id": "MONDO:0009693", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "name": "myeloma - multiple", "description": "" }, { "id": "MIM:254500", "resource": "MIM", "url": "https://www.omim.org/entry/254500", "name": "Multiple myeloma", "description": "Multiple myeloma" } ], "evidence": [ { "id": "254500", "database": "MIM", "url": "https://www.omim.org/entry/254500" } ] } ], "snv": [ { "evidence": [ { "id": "rs1241201658", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1241201658" }, { "id": "rs1241201658", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1241201658#frequency_tab" }, { "id": "rs1241201658", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1241201658" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 180, "end_pos": 180, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NST->SST).", "chr_id": "14", "chr_pos": "105742024", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N180", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1595825771", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1595825771" }, { "id": "rs1595825771", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1595825771" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 182, "end_pos": 182, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NST->NSA).", "chr_id": "14", "chr_pos": "105742019", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T182", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs778837724", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778837724" }, { "id": "rs778837724", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs778837724" }, { "id": "rs778837724", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs778837724" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 182, "end_pos": 182, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NST->NSM).", "chr_id": "14", "chr_pos": "105742018", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T182", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs781478879", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781478879" }, { "id": "rs781478879", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781478879" }, { "id": "rs781478879", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs781478879" }, { "id": "rs781478879", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs781478879" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 210, "end_pos": 210, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKA->NKT).", "chr_id": "14", "chr_pos": "105741935", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A210", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs761235409", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761235409" }, { "id": "rs761235409", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761235409" }, { "id": "rs761235409", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs761235409" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 218, "end_pos": 218, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TIS->NIS).", "chr_id": "14", "chr_pos": "105741910", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T218", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs587773355", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587773355" }, { "id": "rs587773355", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs587773355" }, { "id": "rs587773355", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587773355" }, { "id": "rs587773355", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs587773355#frequency_tab" }, { "id": "rs587773355", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs587773355" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 275, "end_pos": 275, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KTT->NTT).", "chr_id": "14", "chr_pos": "105741641", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "K275", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs587683303", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587683303" }, { "id": "rs587683303", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs587683303" }, { "id": "rs587683303", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587683303" }, { "id": "rs587683303", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs587683303#frequency_tab" }, { "id": "rs587683303", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs587683303" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 284, "end_pos": 284, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "14", "chr_pos": "105741616", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.000599", "site_lbl": "D284", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1205834147", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1205834147" }, { "id": "rs1205834147", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1205834147" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 296, "end_pos": 296, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DKS->NKS).", "chr_id": "14", "chr_pos": "105741580", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D296", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs745691190", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745691190" }, { "id": "rs745691190", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745691190" }, { "id": "rs745691190", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs745691190" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 86, "end_pos": 86, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVN->NVT).", "chr_id": "14", "chr_pos": "105742815", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N86", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1567318295", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1567318295" }, { "id": "rs1567318295", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1567318295" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 90, "end_pos": 90, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SNT->NNT).", "chr_id": "14", "chr_pos": "105742803", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S90", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 117, "end_pos": 117, "sequence_org": "L", "sequence_mut": "A", "comment": "Reduces the affinity for FCGR1A about 5-fold. Abolishes binding to FCGR2A and FCGR3A. Impairs ADCC of virus-infected cells by monocytes. Impairs binding to complement component C1q. Impairs complement-dependent cytotoxicity.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" }, { "database": "PubMed", "id": "11711607", "url": "https://glygen.org/publication/PubMed/11711607" } ] }, { "start_pos": 117, "end_pos": 118, "sequence_org": "LL", "sequence_mut": "AA", "comment": "Abolishes binding to FCGR1A, FCGR2A and FCGR3A. Impairs ADCC of virus-infected cells by monocytes.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" }, { "database": "PubMed", "id": "11711607", "url": "https://glygen.org/publication/PubMed/11711607" } ] }, { "start_pos": 118, "end_pos": 118, "sequence_org": "L", "sequence_mut": "E", "comment": "Reduces the affinity for FCGR1A about 40-fold. Abolishes binding to FCGR2A and FCGR3A. Impairs ADCC of virus-infected cells by monocytes. Impairs binding to complement component C1q. Impairs complement-dependent cytotoxicity.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" } ] }, { "start_pos": 120, "end_pos": 120, "sequence_org": "G", "sequence_mut": "A", "comment": "Reduces the affinity for FCGR1A about 40-fold. Abolishes binding to FCGR2A and FCGR3A. Impairs ADCC of virus-infected cells by monocytes. Decreases binding to complement component C1q. Decreases complement-dependent cytotoxicity.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" }, { "database": "PubMed", "id": "11711607", "url": "https://glygen.org/publication/PubMed/11711607" } ] }, { "start_pos": 205, "end_pos": 205, "sequence_org": "K", "sequence_mut": "A", "comment": "Does not affect binding to FCGR1A. Only slightly affects binding to FCGR2A and FCGR3A. Impairs binding to complement component C1q. Impairs complement-dependent cytotoxicity.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" }, { "database": "PubMed", "id": "11711607", "url": "https://glygen.org/publication/PubMed/11711607" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "79.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "67.79", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "99.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "82.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "98.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "74.33", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "84.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "92.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211896", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211896" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P01857", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01857" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "P01857", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01857" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P01857", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01857" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9664323", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664323", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9664422", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664422", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-977606", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977606", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "P01857", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P01857-1", "url": "https://www.uniprot.org/uniprot/P01857-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P01857-2", "url": "https://www.uniprot.org/uniprot/P01857-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA", "length": 399, "header": "sp|P01857-2|IGHG1_HUMAN Isoform 2 of Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=2 CANONICAL=P01857-2" }, "isoforms": [ { "isoform_ac": "P01857-1", "url": "", "sequence": { "sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK", "length": 330, "header": "sp|P01857-1|IGHG1_HUMAN Isoform 1 of Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=2 CANONICAL=P01857-2" }, "locus": { "chromosome": "HSCHR14_3_CTG1", "start_pos": 210840, "end_pos": 209245, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000631466.1", "url": "https://www.ensembl.org/id/ENST00000631466.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488387.1", "url": "https://www.ensembl.org/id/ENSP00000488387.1" } ] } }, { "isoform_ac": "P01857-2", "url": "", "sequence": { "sequence": "ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA", "length": 399, "header": "sp|P01857-2|IGHG1_HUMAN Isoform 2 of Immunoglobulin heavy constant gamma 1 OS=Homo sapiens OX=9606 GN=IGHG1 PE=1 SV=2 CANONICAL=P01857-2" }, "locus": { "chromosome": "14", "start_pos": 105743071, "end_pos": 105737765, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000390548.6", "url": "https://www.ensembl.org/id/ENST00000390548.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000374990.2", "url": "https://www.ensembl.org/id/ENSP00000374990.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G00420UH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "671", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/671" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" } ] }, { "glytoucan_ac": "G00912UN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "P01857", "database": "UniCarbKB", "url": "" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" }, { "id": "24841998", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24841998" } ] }, { "glytoucan_ac": "G01650EU", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "P01857@N180", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01857@N180" } ] }, { "glytoucan_ac": "G02815KT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "P01857", "database": "UniCarbKB", "url": "" }, { "id": "24841998", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24841998" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" }, { "id": "P01857@N180", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01857@N180" } ] }, { "glytoucan_ac": "G02886BB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "P01857", "database": "UniCarbKB", "url": "" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" }, { "id": "24841998", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24841998" } ] }, { "glytoucan_ac": "G03382KH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "671", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/671" }, { "id": "3661998", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3661998" }, { "id": "2363690", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/2363690" }, { "id": "3567160", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/3567160" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" }, { "id": "24530628", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24530628" }, { "id": "18514042", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18514042" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" }, { "id": "34725484", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725484" }, { "id": "23944609", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23944609" }, { "id": "21609021", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21609021" }, { "id": "31467031", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31467031" } ] }, { "glytoucan_ac": "G03574QJ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "P01857@N180", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01857@N180" } ] }, { "glytoucan_ac": "G05642HQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "671", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/671" }, { "id": "23944609", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23944609" }, { "id": "21609021", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21609021" } ] }, { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "671", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/671" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "671", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/671" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 180, "start_aa": "Asn", "end_pos": 180, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn180", "evidence": [ { "id": "671", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/671" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "31467031", "database": "PubMed", "url": 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"title": "EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family.", "journal": "FEBS letters", "date": "1998", "authors": "Callebaut I, Cossart P, Dehoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029482" } ], "reference": [ { "type": "PubMed", "id": "9883880", "url": "https://glygen.org/publication/PubMed/9883880" } ] }, { "title": "A contractile activity that closes phagosomes in macrophages.", "journal": "Journal of cell science", "date": "1999", "authors": "Swanson JA, Johnson MT, Beningo K, Post P, Mooseker M, Araki N", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029482", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029482" } ], "reference": [ { "type": "PubMed", "id": "9885284", "url": "https://glygen.org/publication/PubMed/9885284" } ] }, { "title": "Fc gamma receptor-mediated activation of phospholipase D regulates 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Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052077", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052077" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 2 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G02815KT. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G02815KT. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052078", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052078" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 3 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G02886BB. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G02886BB. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052079", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052079" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 4 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G05428EU. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G05428EU. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052080", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052080" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 5 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052081", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052081" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 6 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G09197ZW. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G09197ZW. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052082", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052082" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 7 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G10339FR. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G10339FR. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052083", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052083" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 8 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G10486CT. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052084", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052084" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 9 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G11254FL. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G11254FL. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052085", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052085" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 10 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G12580WI. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G12580WI. [PRO:DNx, PMID:30659065]", "evidence": [ { "id": "PR:000052086", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052086" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 11 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G22674CI. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G22674CI. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052087", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052087" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 12 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G25079LO. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G25079LO. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052088", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052088" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 13 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G25520XG. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G25520XG. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052089", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052089" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 14 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G25987BV. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G25987BV. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052090", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052090" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 15 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G28603RA. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G28603RA. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052091", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052091" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 16 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G30159WR. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G30159WR. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052092", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052092" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 17 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G35029YA. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G35029YA. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:30659065]", "evidence": [ { "id": "PR:000052093", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052093" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 18 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G36191CD. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052094", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052094" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 19 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G39213VZ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G39213VZ. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052095", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052095" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 20 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G40834TG. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G40834TG. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052096", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052096" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 21 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G44953PJ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G44953PJ. [PRO:DNx, PMID:30659065]", "evidence": [ { "id": "PR:000052097", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052097" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 22 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G45504EY. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G45504EY. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:30659065]", "evidence": [ { "id": "PR:000052098", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052098" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 23 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G49955PK. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G49955PK. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:30659065]", "evidence": [ { "id": "PR:000052099", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052099" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 24 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G50073PQ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G50073PQ. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052100", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052100" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 25 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G52162PS. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G52162PS. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052101", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052101" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 26 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G54600FO. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G54600FO. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052102", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052102" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 27 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G55070DG. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G55070DG. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052103", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052103" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 28 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G57317CE. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052104", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052104" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 29 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G57776ZU. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G57776ZU. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052105", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052105" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 30 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:30659065]", "evidence": [ { "id": "PR:000052106", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052106" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 31 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G59937CP. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G59937CP. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052107", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052107" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 32 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G60923RB. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G60923RB. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052108", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052108" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 33 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G61855PQ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G61855PQ. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052109", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052109" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 34 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G65184UU. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G65184UU. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052110", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052110" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 35 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G65681LR. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G65681LR. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:30659065]", "evidence": [ { "id": "PR:000052111", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052111" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 36 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G67324HN. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G67324HN. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052112", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052112" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 37 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G68318VE. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G68318VE. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052113", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052113" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 38 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G72787SB. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G72787SB. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052114", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052114" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 39 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G72790NZ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G72790NZ. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:30659065]", "evidence": [ { "id": "PR:000052115", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052115" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 40 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G72791KH. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G72791KH. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052116", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052116" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 41 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G78059CC. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052117", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052117" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 42 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G80475RE. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G80475RE. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052118", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052118" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 43 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan structure is represented by GlyTouCan:G80858MF. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G80858MF. [PRO:DNx, PMID:21609021]", "evidence": [ { "id": "PR:000052119", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052119" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 44 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G83555HU. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052120", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052120" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 45 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G83633GK. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G83633GK. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052121", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052121" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 46 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G83646BJ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G83646BJ. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052122", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052122" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 47 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G85582CB. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G85582CB. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052123", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052123" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 48 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G85740DB. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G85740DB. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052124", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052124" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 49 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:30659065]", "evidence": [ { "id": "PR:000052125", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052125" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 50 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G88725PI. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G88725PI. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580, PMID:30659065]", "evidence": [ { "id": "PR:000052126", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052126" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 51 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G90734RJ. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G90734RJ. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052127", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052127" } ] }, { "name": "immunoglobulin heavy constant gamma 1 N-glycosylated 52 (human)", "definition": "An immunoglobulin heavy constant gamma 1 (human) that has been N-glycosylated at the residue equivalent to Asn-180 of the amino acid sequence represented by UniProtKB:P01857-1, in which the glycan composition is represented by GlyTouCan:G95865ZB. Example: UniProtKB:P01857-1, Asn-180, MOD:00160~GNO:G95865ZB. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000052128", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052128" } ] } ], "site_annotation": [ { "start_pos": 180, "end_pos": 182, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "(Microbial infection) Deglycosylation on Asn-180 by S.pyogenes EndoS or Endos2 endoglucosidases prevents interaction between immunoglobulin-gamma (IgG) and Fc receptors, impairing ability to activate the complement pathway.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" }, { "database": "PubMed", "id": "11406581", "url": "https://glygen.org/publication/PubMed/11406581" }, { "database": "PubMed", "id": "23865566", "url": "https://glygen.org/publication/PubMed/23865566" }, { "database": "PubMed", "id": "20357243", "url": "https://glygen.org/publication/PubMed/20357243" } ] }, { "annotation": "Glycosylation on Asn-180 is required for interaction with Fc receptors and ability to activate the complement pathway.", "evidence": [ { "database": "UniProtKB", "id": "P01857", "url": "https://www.uniprot.org/uniprot/P01857" }, { "database": "PubMed", "id": "20357243", "url": "https://glygen.org/publication/PubMed/20357243" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 180 ], "o_linked_sites": [], "snv_sites": [ 86, 90, 180, 182, 210, 218, 275, 284, 296 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 180, "end_pos": 182 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 260 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", 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"n_linked_glycans", "count": 206 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": 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