{ "uniprot_canonical_ac": "P01854-2", "uniprot_ac": "P01854", "uniprot_id": "IGHE_HUMAN", "mass": { "chemical_mass": 59539.0, "monoisotopic_mass": 59539.0 }, "refseq": {}, "gene_names": [ { "name": "IGHE", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P01854", "id": "P01854" } ], "protein_names": [ { "name": "Immunoglobulin heavy constant epsilon", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P01854" }, { "name": "Ig epsilon chain C region ND", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01854" }, { "name": "Ig epsilon chain C region", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01854" } ], "function": [ { "annotation": "Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854#function" }, { "database": "PubMed", "id": "20176268", "url": "https://glygen.org/publication/PubMed/20176268" }, { "database": "PubMed", "id": "22158414", "url": "https://glygen.org/publication/PubMed/22158414" }, { "database": "PubMed", "id": "17576170", "url": "https://glygen.org/publication/PubMed/17576170" } ] }, { "annotation": "Constant region of membrane-bound IgE (long mIgE), part of the B cell receptor complex (BCR). Upon antigen cross-linking triggers quick BCR signaling, ensuring survival of IgE-switched B cells and differentiation into plasma cells, thus regulating both primary and memory IgE responses.", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854#function" }, { "database": "PubMed", "id": "8976175", "url": "https://glygen.org/publication/PubMed/8976175" }, { "database": "PubMed", "id": "20458139", "url": "https://glygen.org/publication/PubMed/20458139" } ] }, { "annotation": "Constant region of membrane-bound IgE (short mIgE), part of the B cell receptor complex (BCR). Upon antigen cross-linking initiates slower but sustained BCR signaling that negatively regulates mature B cell proliferation.", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854#function" }, { "database": "PubMed", "id": "8976175", "url": "https://glygen.org/publication/PubMed/8976175" } ] }, { "annotation": "Constant region of secreted IgE, also known as the Fc region of IgE antibody. Mediates IgE effector functions on myeloid and lymphoid cells primarily via two Fc receptors, the high-affinity IgE Fc receptor complex/FCER1A:MS4A2:FCGR1A and the low-affinity FCER2 receptor, which upon antigen/allergen cross-linking initiate signaling pathways that lead to immune cell activation and differentiation (PubMed:2167225, PubMed:8114916, PubMed:7544003, PubMed:8551243, PubMed:25629393, PubMed:33840121). Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions (PubMed:8114916, PubMed:7544003, PubMed:8551243, PubMed:25629393, PubMed:33840121). Stimulates the high-affinity IgE Fc receptor complex/FCER1A:MS4A2:FCGR1A on mast cells, basophils and eosinophils leading to secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes (PubMed:8114916, PubMed:8551243, PubMed:25629393). On macrophages, cross-linking of FCER2 by IgE immune complexes induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003). Activates macrophages to kill tumor cells via antigen-specific antibody-dependent cytotoxicity (ADCC). Triggers differentiation of quiescent M0 macrophages toward M1 state and reprograms M2 macrophages toward a proinflammatory state with antitumor functions (PubMed:30956175). Stimulates FCER2 on B cells and initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225).", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854#function" }, { "database": "PubMed", "id": "20176268", "url": "https://glygen.org/publication/PubMed/20176268" }, { "database": "PubMed", "id": "10917520", "url": "https://glygen.org/publication/PubMed/10917520" }, { "database": "PubMed", "id": "7995941", "url": "https://glygen.org/publication/PubMed/7995941" }, { "database": "PubMed", "id": "8551243", "url": "https://glygen.org/publication/PubMed/8551243" }, { "database": "PubMed", "id": "25629393", "url": "https://glygen.org/publication/PubMed/25629393" }, { "database": "PubMed", "id": "7544003", "url": "https://glygen.org/publication/PubMed/7544003" }, { "database": "PubMed", "id": "33840121", "url": "https://glygen.org/publication/PubMed/33840121" }, { "database": "PubMed", "id": "30956175", "url": "https://glygen.org/publication/PubMed/30956175" }, { "database": "PubMed", "id": "8114916", "url": "https://glygen.org/publication/PubMed/8114916" }, { "database": "PubMed", "id": "2167225", "url": "https://glygen.org/publication/PubMed/2167225" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "28.85", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "67.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "45.09", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "57.16", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "23.05", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "59.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "34.21", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "25.75", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "35.86", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000211891", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211891" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P01854", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01854" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", 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"ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLAGGSAQSQRAPDRVLCHSGQQQGLPRAAGGSVPHPRCHCGAGRADWPGPPELDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAAITLLMVQRFLSATRQGRPQTSLDYTNVLQPHA", "length": 546, "header": "sp|P01854-2|IGHE_HUMAN Isoform 2 of Immunoglobulin heavy constant epsilon OS=Homo sapiens OX=9606 GN=IGHE PE=1 SV=2 CANONICAL=P01854-2" }, "isoforms": [ { "isoform_ac": "P01854-1", "url": "", "sequence": { "sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK", "length": 428, "header": "sp|P01854-1|IGHE_HUMAN Isoform 1 of Immunoglobulin heavy constant epsilon OS=Homo sapiens OX=9606 GN=IGHE PE=1 SV=2 CANONICAL=P01854-2" }, "locus": { "chromosome": "HSCHR14_3_CTG1", "start_pos": 69502, "end_pos": 67843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000610670.2", "url": "https://www.ensembl.org/id/ENST00000610670.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000481089.1", "url": "https://www.ensembl.org/id/ENSP00000481089.1" } ] } }, { "isoform_ac": "P01854-2", "url": "", "sequence": { "sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLAGGSAQSQRAPDRVLCHSGQQQGLPRAAGGSVPHPRCHCGAGRADWPGPPELDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAAITLLMVQRFLSATRQGRPQTSLDYTNVLQPHA", "length": 546, "header": "sp|P01854-2|IGHE_HUMAN Isoform 2 of Immunoglobulin heavy constant epsilon OS=Homo sapiens OX=9606 GN=IGHE PE=1 SV=2 CANONICAL=P01854-2" }, "locus": {} }, { "isoform_ac": "P01854-3", "url": "", "sequence": { "sequence": "ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPELDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAAITLLMVQRFLSATRQGRPQTSLDYTNVLQPHA", "length": 494, "header": "sp|P01854-3|IGHE_HUMAN Isoform 3 of Immunoglobulin heavy constant epsilon OS=Homo sapiens OX=9606 GN=IGHE PE=1 SV=2 CANONICAL=P01854-2" }, "locus": { "chromosome": "14", "start_pos": 105601728, "end_pos": 105597694, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000641420.1", "url": "https://www.ensembl.org/id/ENST00000641420.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000492979.1", "url": "https://www.ensembl.org/id/ENSP00000492979.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G02030ZB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" }, { "id": "24308486", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24308486" } ] }, { "glytoucan_ac": "G03382KH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" }, { "id": "25824821", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25824821" } ] }, { "glytoucan_ac": "G05850WN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" }, { "id": "24308486", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24308486" } ] }, { "glytoucan_ac": "G08146BT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "P01854", "database": "UniCarbKB", "url": "" }, { "id": "24308486", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24308486" }, { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" } ] }, { "glytoucan_ac": "G11629QQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" }, { "id": "24308486", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24308486" } ] }, { "glytoucan_ac": "G22140GZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "P01854", "database": "UniCarbKB", "url": "" }, { "id": "24308486", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24308486" }, { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" } ] }, { "glytoucan_ac": "G22310AV", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": "765", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/765" }, { "id": "24308486", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24308486" } ] }, { "glytoucan_ac": "G23863VK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 146, "start_aa": "Asn", "end_pos": 146, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn146", "evidence": [ { "id": 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"https://glygen.org/publication/PubMed/8986718" } ] }, { "title": "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Hendricks-Taylor LR, Motto DG, Zhang J, Siraganian RP, Koretzky GA", "evidence": [ { "database": "Reactome", "id": "R-HSA-2871796", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2871796" } ], "reference": [ { "type": "PubMed", "id": "8995445", "url": "https://glygen.org/publication/PubMed/8995445" } ] }, { "title": "Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex.", "journal": "FEBS letters", "date": "1997", "authors": "Miloux B, Laurent P, Bonnin O, Lupker J, Caput D, Vita N, Ferrara P", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { 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"url": "https://glygen.org/publication/PubMed/9199344" } ] }, { "title": "The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Vonakis BM, Chen H, Haleem-Smith H, Metzger H", "evidence": [ { "database": "Reactome", "id": "R-HSA-2454202", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2454202" } ], "reference": [ { "type": "PubMed", "id": "9295361", "url": "https://glygen.org/publication/PubMed/9295361" } ] }, { "title": "Spontaneous autophosphorylation of Lyn tyrosine kinase at both its activation segment and C-terminal tail confers altered substrate specificity.", "journal": "Biochemistry", "date": "1998", "authors": "Donella-Deana A, Cesaro L, Ruzzene M, Brunati AM, Marin O, Pinna LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-2454202", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2454202" } ], "reference": [ { 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"https://glygen.org/publication/PubMed/9651359" } ] }, { "title": "The role of IL-13 and its receptor in allergy and inflammatory responses.", "journal": "The Journal of allergy and clinical immunology", "date": "1998", "authors": "de Vries JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "9723655", "url": "https://glygen.org/publication/PubMed/9723655" } ] }, { "title": "Interferon-gamma-induced factor binding to the interleukin-4-responsive element of CD23b promoter in human tonsillar mononuclear cells: role in transient up-regulation of the interleukin-4-induced CD23b mRNA.", "journal": "Molecular immunology", "date": "1998", "authors": "Park HJ, So EY, Lee CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "9736340", "url": "https://glygen.org/publication/PubMed/9736340" } ] }, { "title": "Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Roy B, Cathcart MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "9822675", "url": "https://glygen.org/publication/PubMed/9822675" } ] }, { "title": "STAT3 is required for the gp130-mediated full activation of the c-myc gene.", "journal": "The Journal of experimental medicine", "date": "1999", "authors": "Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, Hibi M, Hirano T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6785807", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6785807" } ], "reference": [ { "type": "PubMed", "id": "9874564", "url": "https://glygen.org/publication/PubMed/9874564" } ] }, { "title": "Mechanism of activation of Pak1 kinase by membrane localization.", "journal": "Oncogene", "date": "1999", "authors": "Lu W, Mayer BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2871796", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2871796" } ], "reference": [ { "type": "PubMed", "id": "9989831", "url": "https://glygen.org/publication/PubMed/9989831" } ] } ], "pathway": [ { "id": "R-HSA-2454202", "name": "Fc epsilon receptor (FCERI) signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2454202", "resource": "Reactome", "description": "Fc epsilon receptor (FCERI) signaling" }, { "id": "R-HSA-2730905", "name": "Role of LAT2/NTAL/LAB on calcium mobilization", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2730905", "resource": "Reactome", "description": "Role of LAT2/NTAL/LAB on calcium mobilization" }, { "id": "R-HSA-2871796", "name": "FCERI mediated MAPK activation", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0030225", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "macrophage activation", "id": "GO:0042116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042116", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "mast cell degranulation", "id": "GO:0043303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043303", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "eosinophil degranulation", "id": "GO:0043308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043308", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "antibody-dependent cellular cytotoxicity", "id": "GO:0001788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001788", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "Fc receptor-mediated immune complex endocytosis", "id": "GO:0160006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0160006", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "B cell antigen processing and presentation", "id": "GO:0002450", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002450", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "type I hypersensitivity", "id": "GO:0016068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016068", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "adaptive immune memory response", "id": "GO:0090716", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090716", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" }, { "name": "primary adaptive immune response", "id": "GO:0090720", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090720", "evidence": [ { "database": "UniProtKB", "id": "P01854", "url": "https://www.uniprot.org/uniprot/P01854" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "immunoglobulin heavy constant epsilon N-glycosylated 1 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-146 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P01854-1, Asn-146, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052048", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052048" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 2 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-146 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P01854-1, Asn-146, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052049", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052049" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 3 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-146 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G57818FI. Example: UniProtKB:P01854-1, Asn-146, MOD:00160~GNO:G57818FI. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052050", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052050" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 4 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-146 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G61627IG. Example: UniProtKB:P01854-1, Asn-146, MOD:00160~GNO:G61627IG. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052051", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052051" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 5 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-146 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65219TP. Example: UniProtKB:P01854-1, Asn-146, MOD:00160~GNO:G65219TP. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052052", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052052" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 6 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-21 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P01854-1, Asn-21, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052053", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052053" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 7 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-21 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G57818FI. Example: UniProtKB:P01854-1, Asn-21, MOD:00160~GNO:G57818FI. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052054", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052054" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 8 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-21 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G61627IG. Example: UniProtKB:P01854-1, Asn-21, MOD:00160~GNO:G61627IG. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052055", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052055" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 9 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-21 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65186XA. Example: UniProtKB:P01854-1, Asn-21, MOD:00160~GNO:G65186XA. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052056", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052056" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 10 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-21 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65219TP. Example: UniProtKB:P01854-1, Asn-21, MOD:00160~GNO:G65219TP. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052057", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052057" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 11 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-252 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P01854-1, Asn-252, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052058", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052058" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 12 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-252 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G57818FI. Example: UniProtKB:P01854-1, Asn-252, MOD:00160~GNO:G57818FI. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052059", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052059" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 13 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-252 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G61627IG. Example: UniProtKB:P01854-1, Asn-252, MOD:00160~GNO:G61627IG. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052060", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052060" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 14 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-252 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65219TP. Example: UniProtKB:P01854-1, Asn-252, MOD:00160~GNO:G65219TP. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052061", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052061" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 15 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-275 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan composition is represented by GlyTouCan:G02815KT. Example: UniProtKB:P01854-1, Asn-275, MOD:00160~GNO:G02815KT. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000052062", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052062" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 16 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-275 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G39617JJ. Example: UniProtKB:P01854-1, Asn-275, MOD:00160~GNO:G39617JJ. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052063", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052063" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 17 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-275 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G54059XR. Example: UniProtKB:P01854-1, Asn-275, MOD:00160~GNO:G54059XR. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052064", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052064" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 18 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P01854-1, Asn-49, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052065", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052065" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 19 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P01854-1, Asn-49, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052066", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052066" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 20 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G57818FI. Example: UniProtKB:P01854-1, Asn-49, MOD:00160~GNO:G57818FI. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052067", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052067" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 21 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G61627IG. Example: UniProtKB:P01854-1, Asn-49, MOD:00160~GNO:G61627IG. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052068", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052068" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 22 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65186XA. Example: UniProtKB:P01854-1, Asn-49, MOD:00160~GNO:G65186XA. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052069", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052069" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 23 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-49 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65219TP. Example: UniProtKB:P01854-1, Asn-49, MOD:00160~GNO:G65219TP. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052070", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052070" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 24 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-99 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P01854-1, Asn-99, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052071", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052071" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 25 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-99 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P01854-1, Asn-99, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052072", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052072" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 26 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-99 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G57818FI. Example: UniProtKB:P01854-1, Asn-99, MOD:00160~GNO:G57818FI. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052073", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052073" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 27 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-99 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G61627IG. Example: UniProtKB:P01854-1, Asn-99, MOD:00160~GNO:G61627IG. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052074", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052074" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 28 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-99 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65186XA. Example: UniProtKB:P01854-1, Asn-99, MOD:00160~GNO:G65186XA. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052075", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052075" } ] }, { "name": "immunoglobulin heavy constant epsilon N-glycosylated 29 (human)", "definition": "An immunoglobulin heavy constant epsilon (human) that has been N-glycosylated at the residue equivalent to Asn-99 of the amino acid sequence represented by UniProtKB:P01854-1, in which the glycan structure is represented by GlyTouCan:G65219TP. Example: UniProtKB:P01854-1, Asn-99, MOD:00160~GNO:G65219TP. [PRO:DNx, PMID:24308486]", "evidence": [ { "id": "PR:000052076", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000052076" } ] } ], "site_annotation": [ { "start_pos": 146, "end_pos": 148, "annotation": "n_glycosylation_sequon" }, { "start_pos": 21, "end_pos": 23, "annotation": "n_glycosylation_sequon" }, { "start_pos": 252, "end_pos": 254, "annotation": "n_glycosylation_sequon" }, { "start_pos": 264, "end_pos": 266, "annotation": "n_glycosylation_sequon" }, { "start_pos": 275, "end_pos": 277, "annotation": "n_glycosylation_sequon" }, { "start_pos": 49, "end_pos": 51, "annotation": "n_glycosylation_sequon" }, { "start_pos": 99, "end_pos": 101, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "sequence_features": { "n_linked_sites": [ 21, 49, 99, 146, 252, 264, 275 ], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 146, "end_pos": 148 }, { "start_pos": 21, "end_pos": 23 }, { "start_pos": 252, "end_pos": 254 }, { "start_pos": 264, "end_pos": 266 }, { "start_pos": 275, "end_pos": 277 }, { "start_pos": 49, "end_pos": 51 }, { "start_pos": 99, "end_pos": 101 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 287 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_glycans", "count": 126 }, { "field": "n_linked_glycan_sites", "count": 15 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 7 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 280 }, { "field": "total_sites", "count": 8 }, { "field": "n_linked_glycans", "count": 126 }, { "field": "n_linked_glycan_sites", "count": 8 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 214 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }