{ "uniprot_canonical_ac": "P01591-1", "uniprot_ac": "P01591", "uniprot_id": "IGJ_HUMAN", "mass": { "chemical_mass": 18099.0, "monoisotopic_mass": 18099.0 }, "refseq": { "ac": "NP_653247", "name": "immunoglobulin J chain precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653247" }, "gene_names": [ { "name": "JCHAIN", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P01591", "id": "P01591" }, { "name": "IGCJ; IGJ; JCH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653247", "id": "NP_653247" }, { "name": "IGCJ", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P01591", "id": "P01591" }, { "name": "IGJ", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P01591", "id": "P01591" }, { "name": "JCHAIN", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653247", "id": "NP_653247" } ], "protein_names": [ { "name": "Immunoglobulin J chain", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P01591" }, { "name": "Joining chain of multimeric IgA and IgM", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01591" }, { "name": "immunoglobulin J chain precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653247", "id": "NP_653247" }, { "name": "immunoglobulin J chain; IgJ chain; immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653247", "id": "NP_653247" } ], "function": [ { "annotation": "IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF-kappaB signaling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_653247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653247" }, { "database": "PubMed", "id": "37539706", "url": "https://glygen.org/publication/PubMed/37539706" } ] }, { "annotation": "Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.", "evidence": [ { "database": "UniProtKB", "id": "P01591", "url": "https://www.uniprot.org/uniprot/P01591#function" }, { "database": "UniProtKB", "id": "P01592", "url": "https://www.uniprot.org/uniprot/P01592#function" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "P01591", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P01591" }, { "id": "rs374027021", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs374027021" }, { "id": "rs374027021", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs374027021" }, { "id": "rs374027021", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs374027021" }, { "id": "rs374027021", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs374027021#frequency_tab" }, { "id": "rs374027021", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs374027021" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 105, "end_pos": 105, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "I", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NQI->NQT).", "chr_id": "4", "chr_pos": "70656495", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "I105", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": 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"id": "rs752044808", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752044808" }, { "id": "rs752044808", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs752044808" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 109, "end_pos": 109, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "4", "chr_pos": "70656483", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T109", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs756823556", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756823556" }, { "id": "rs756823556", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756823556" }, { "id": "rs756823556", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756823556" } ], "glycoeffect": [ 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"database": "Bgee", "id": "ENSG00000132465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000132465" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000132465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000132465" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P01591", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01591" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the 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"MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", 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"MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": 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"BioXpress", "id": "P01591", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01591" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P01591", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01591" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01591" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=1 CANONICAL=P01591-1" }, "locus": { "chromosome": "4", "start_pos": 70666490, "end_pos": 70656386, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000391614.7", "url": "https://www.ensembl.org/id/ENST00000391614.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000426045.1", "url": "https://www.ensembl.org/id/ENSP00000426045.1" } ] } }, { "isoform_ac": "P01591-1", "url": "", "sequence": { "sequence": "MKNHLLFWGVLAVFIKAVHVKAQEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD", "length": 159, "header": "sp|P01591-1|IGJ_HUMAN Isoform 1 of Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4 CANONICAL=P01591-1" }, "locus": { "chromosome": "4", "start_pos": 70666490, "end_pos": 70656332, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000510437.5", "url": "https://www.ensembl.org/id/ENST00000510437.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000426687.1", "url": "https://www.ensembl.org/id/ENSP00000426687.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 109, "start_aa": "Thr", "end_pos": 109, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr109", "evidence": [ { "id": "P01591", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 67, "start_aa": "Asn", "end_pos": 67, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn67", "evidence": [ { "id": "24190977", "database": "PubMed", "url": 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"https://glygen.org/publication/PubMed/24841998" }, { "id": "24766575", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24766575" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "P01591@N71", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01591@N71" } ] }, { "glytoucan_ac": "G02030ZB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 71, "start_aa": "Asn", "end_pos": 71, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn71", "evidence": [ { "id": "277", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/277" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" }, { "id": "25802287", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25802287" } ] }, { "glytoucan_ac": "G02315DX", 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"N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 71, "start_aa": "Asn", "end_pos": 71, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn71", "evidence": [ { "id": "277", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/277" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" }, { "id": "20030399", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/20030399" } ] }, { "glytoucan_ac": "G05724UK", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 71, "start_aa": "Asn", "end_pos": 71, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn71", "evidence": [ { "id": "277", "database": "GlyConnect", "url": 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Receptor-mediated uptake with recycling of the protein.", "journal": "The Biochemical journal", "date": "1979", "authors": "Smith A, Morgan WT", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "496916", "url": "https://glygen.org/publication/PubMed/496916" } ] }, { "title": "Studies on the structures of haptoglobin 1-1 and hemoglobin in the haptoglobin-hemoglobin complex.", "journal": "Biochemical and biophysical research communications", "date": "1971", "authors": "Waks M, Kahn PC, Beychok S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "5135507", "url": "https://glygen.org/publication/PubMed/5135507" } ] }, { "title": "Hemopexin-mediated heme uptake by liver. 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Subunit interaction probed by cross-linking.", "journal": "The Journal of biological chemistry", "date": "1981", "authors": "Greer J, Liao WD, Brown WE", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "7263686", "url": "https://glygen.org/publication/PubMed/7263686" } ] }, { "title": "Hemopexin-mediated transport of heme into isolated rat hepatocytes.", "journal": "The Journal of biological chemistry", "date": "1981", "authors": "Smith A, Morgan WT", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "7287740", "url": "https://glygen.org/publication/PubMed/7287740" } ] }, { "title": "Haemoglobin binding with haptoglobin. Unequivocal demonstration that the beta-chains of human haemoglobin bind to haptoglobin.", "journal": "The Biochemical journal", "date": "1980", "authors": "Kazim AL, Atassi MZ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "7378053", "url": "https://glygen.org/publication/PubMed/7378053" } ] }, { "title": "Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.", "journal": "Nature", "date": "1994", "authors": "Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "7509040", "url": "https://glygen.org/publication/PubMed/7509040" } ] }, { "title": "The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Moore KL, Eaton SF, Lyons DE, Lichenstein HS, Cummings RD, McEver RP", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "7521878", "url": "https://glygen.org/publication/PubMed/7521878" } ] }, { "title": "Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule.", "journal": "The Journal of cell biology", "date": "1994", "authors": "Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "8163559", "url": "https://glygen.org/publication/PubMed/8163559" } ] }, { "title": "The surrogate light chain in B-cell development.", "journal": "Immunology today", "date": "1993", "authors": "Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "8166770", "url": "https://glygen.org/publication/PubMed/8166770" } ] }, { "title": "The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin.", "journal": "The Journal of cell biology", "date": "1993", "authors": "Zhang Z, Morla AO, Vuori K, Bauer JS, Juliano RL, Ruoslahti E", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "8314844", "url": "https://glygen.org/publication/PubMed/8314844" } ] }, { "title": "In vivo fate of hemopexin and heme-hemopexin complexes in the rat.", "journal": "Archives of biochemistry and biophysics", "date": "1993", "authors": "Potter D, Chroneos ZC, Baynes JW, Sinclair PR, Gorman N, Liem HH, Muller-Eberhard U, Thorpe SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "8424694", "url": "https://glygen.org/publication/PubMed/8424694" } ] }, { "title": "Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation.", "journal": "Biochemistry", "date": "1996", "authors": "Miller YI, Smith A, Morgan WT, Shaklai N", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "8855948", "url": "https://glygen.org/publication/PubMed/8855948" } ] }, { "title": "An endothelial receptor for oxidized low-density lipoprotein.", "journal": "Nature", "date": "1997", "authors": "Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, Masaki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9052782", "url": "https://glygen.org/publication/PubMed/9052782" } ] }, { "title": "Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae.", "journal": "Infection and immunity", "date": "1997", "authors": "Bos MP, Grunert F, Belland RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9169774", "url": "https://glygen.org/publication/PubMed/9169774" } ] }, { "title": "An antagonist decoy receptor and a death domain-containing receptor for TRAIL.", "journal": "Science (New York, N.Y.)", "date": "1997", "authors": "Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9242610", "url": "https://glygen.org/publication/PubMed/9242610" } ] }, { "title": "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Tsuji M, Ezumi Y, Arai M, Takayama H", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9295288", "url": "https://glygen.org/publication/PubMed/9295288" } ] }, { "title": "Epithelial cell adhesion molecule (Ep-CAM) modulates cell-cell interactions mediated by classic cadherins.", "journal": "The Journal of cell biology", "date": "1997", "authors": "Litvinov SV, Balzar M, Winter MJ, Bakker HA, Briaire-de Bruijn IH, Prins F, Fleuren GJ, Warnaar SO", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9382878", "url": "https://glygen.org/publication/PubMed/9382878" } ] }, { "title": "Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor.", "journal": "The Biochemical journal", "date": "1998", "authors": "Yoshida H, Kondratenko N, Green S, Steinberg D, Quehenberger O", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9693095", "url": "https://glygen.org/publication/PubMed/9693095" } ] }, { "title": "Transfer of heme from heme-albumin to hemopexin.", "journal": "Biochimica et biophysica acta", "date": "1976", "authors": "Morgan WT, Liem HH, Sutor RP, Muller-Ebergard U", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "971416", "url": "https://glygen.org/publication/PubMed/971416" } ] }, { "title": "Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "1998", "authors": "Moriwaki H, Kume N, Sawamura T, Aoyama T, Hoshikawa H, Ochi H, Nishi E, Masaki T, Kita T", "evidence": [ { "database": "Reactome", "id": "R-HSA-202733", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-202733" } ], "reference": [ { "type": "PubMed", "id": "9763524", "url": "https://glygen.org/publication/PubMed/9763524" } ] } ], "pathway": [ { "id": "hsa:3512", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3512", 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[PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051960", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051960" } ] }, { "name": "immunoglobulin J chain N-glycosylated 4 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G09197ZW. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G09197ZW. 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[PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051962", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051962" } ] }, { "name": "immunoglobulin J chain N-glycosylated 6 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G22674CI. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G22674CI. [PRO:DNx, PMID:25802287]", "evidence": [ { "id": "PR:000051963", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051963" } ] }, { "name": "immunoglobulin J chain N-glycosylated 7 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G23505EP. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G23505EP. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051964", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051964" } ] }, { "name": "immunoglobulin J chain N-glycosylated 8 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G27126ED. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G27126ED. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051965", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051965" } ] }, { "name": "immunoglobulin J chain N-glycosylated 9 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G32392SM. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G32392SM. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051966", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051966" } ] }, { "name": "immunoglobulin J chain N-glycosylated 10 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G36191CD. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G36191CD. [PRO:DNx, PMID:108268, PMID:25802287]", "evidence": [ { "id": "PR:000051967", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051967" } ] }, { "name": "immunoglobulin J chain N-glycosylated 11 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G44211QA. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G44211QA. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051968", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051968" } ] }, { "name": "immunoglobulin J chain N-glycosylated 12 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G49018RC. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G49018RC. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051969", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051969" } ] }, { "name": "immunoglobulin J chain N-glycosylated 13 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G49955PK. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G49955PK. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051970", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051970" } ] }, { "name": "immunoglobulin J chain N-glycosylated 14 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G52934AK. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G52934AK. [PRO:DNx, PMID:25802287]", "evidence": [ { "id": "PR:000051971", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051971" } ] }, { "name": "immunoglobulin J chain N-glycosylated 15 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051972", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051972" } ] }, { "name": "immunoglobulin J chain N-glycosylated 16 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G62595EF. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G62595EF. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051973", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051973" } ] }, { "name": "immunoglobulin J chain N-glycosylated 17 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G65184UU. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G65184UU. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051974", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051974" } ] }, { "name": "immunoglobulin J chain N-glycosylated 18 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G65681LR. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G65681LR. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051975", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051975" } ] }, { "name": "immunoglobulin J chain N-glycosylated 19 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G67324HN. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G67324HN. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051976", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051976" } ] }, { "name": "immunoglobulin J chain N-glycosylated 20 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G72790NZ. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G72790NZ. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051977", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051977" } ] }, { "name": "immunoglobulin J chain N-glycosylated 21 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G78059CC. [PRO:DNx, PMID:25802287]", "evidence": [ { "id": "PR:000051978", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051978" } ] }, { "name": "immunoglobulin J chain N-glycosylated 22 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G81282CC. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G81282CC. [PRO:DNx, PMID:25802287]", "evidence": [ { "id": "PR:000051979", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051979" } ] }, { "name": "immunoglobulin J chain N-glycosylated 23 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G83646BJ. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G83646BJ. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051980", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051980" } ] }, { "name": "immunoglobulin J chain N-glycosylated 24 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G84467IZ. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G84467IZ. [PRO:DNx, PMID:108268]", "evidence": [ { "id": "PR:000051981", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051981" } ] }, { "name": "immunoglobulin J chain N-glycosylated 25 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G85282JO. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G85282JO. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051982", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051982" } ] }, { "name": "immunoglobulin J chain N-glycosylated 26 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G86182NS. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G86182NS. [PRO:DNx, PMID:24766575, PMID:24841998]", "evidence": [ { "id": "PR:000051983", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051983" } ] }, { "name": "immunoglobulin J chain N-glycosylated 27 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:24766575, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051984", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051984" } ] }, { "name": "immunoglobulin J chain N-glycosylated 28 (human)", "definition": "An immunoglobulin J chain (human) that has been N-glycosylated at the residue equivalent to Asn-71 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan structure is represented by GlyTouCan:G91365ZQ. Example: UniProtKB:P01591-1, Asn-71, MOD:00160~GNO:G91365ZQ. [PRO:DNx, PMID:108268]", "evidence": [ { "id": "PR:000051985", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051985" } ] }, { "name": "immunoglobulin J chain O-glycosylated 1 (human)", "definition": "An immunoglobulin J chain (human) that has been O-glycosylated at the residue equivalent to Thr-109 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01591-1, Thr-109, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000051986", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051986" } ] }, { "name": "immunoglobulin J chain O-glycosylated 2 (human)", "definition": "An immunoglobulin J chain (human) that has been O-glycosylated at the residue equivalent to Thr-97 of the amino acid sequence represented by UniProtKB:P01591-1, in which the glycan composition is represented by GlyTouCan:G17015OC. Example: UniProtKB:P01591-1, Thr-97, MOD:00005~GNO:G17015OC. [PRO:DNx, PMID:26598643]", "evidence": [ { "id": "PR:000051987", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051987" } ] } ], "site_annotation": [ { "start_pos": 71, "end_pos": 73, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 67, 68, 71 ], "o_linked_sites": [ 97, 109 ], "snv_sites": [ 35, 71, 97, 105, 109, 118, 131 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 71, "end_pos": 73 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 103 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 98 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 100 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 98 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 130 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }