{
    "uniprot_canonical_ac": "P01112-1",
    "uniprot_ac": "P01112",
    "uniprot_id": "RASH_HUMAN",
    "mass": {
        "chemical_mass": 21298.0,
        "monoisotopic_mass": 21298.0
    },
    "refseq": {
        "ac": "NP_001123914",
        "name": "GTPase HRas isoform 1",
        "summary": "This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008].",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
    },
    "gene_names": [
        {
            "name": "HRAS",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/P01112",
            "id": "P01112"
        },
        {
            "name": "C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO; H-RASIDX; HAMSV; HRAS1; p21ras; RASH1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914",
            "id": "NP_001123914"
        },
        {
            "name": "HRAS1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/P01112",
            "id": "P01112"
        },
        {
            "name": "HRAS",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914",
            "id": "NP_001123914"
        }
    ],
    "protein_names": [
        {
            "name": "GTPase HRas",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "P01112"
        },
        {
            "name": "3.6.5.2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P01112"
        },
        {
            "name": "GTPase HRas isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914",
            "id": "NP_001123914"
        },
        {
            "name": "H-Ras-1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P01112"
        },
        {
            "name": "Ha-Ras1 proto-oncoprotein; Ras family small GTP binding protein H-Ras; Harvey rat sarcoma viral oncogene homolog; p19 H-RasIDX protein; transforming protein p21; GTPase HRas; GTP- and GDP-binding peptide B; transformation gene: oncogene HAMSV; c-has/bas p21 protein; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914",
            "id": "NP_001123914"
        },
        {
            "name": "Ha-Ras",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P01112"
        },
        {
            "name": "Transforming protein p21",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P01112"
        },
        {
            "name": "c-H-ras",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P01112"
        },
        {
            "name": "p21ras",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "P01112"
        }
    ],
    "function": [
        {
            "annotation": "A very mild phenotype in six individuals of a three-generation family with the novel HRAS variant c.176C > G p.(Ala59Gly): Emergence of a new HRAS-related RASopathy distinct from Costello syndrome.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001123914",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
                },
                {
                    "database": "PubMed",
                    "id": "37194190",
                    "url": "https://glygen.org/publication/PubMed/37194190"
                }
            ]
        },
        {
            "annotation": "Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001123914",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
                },
                {
                    "database": "PubMed",
                    "id": "37192201",
                    "url": "https://glygen.org/publication/PubMed/37192201"
                }
            ]
        },
        {
            "annotation": "ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21[HRAS] splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001123914",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
                },
                {
                    "database": "PubMed",
                    "id": "37820992",
                    "url": "https://glygen.org/publication/PubMed/37820992"
                }
            ]
        },
        {
            "annotation": "Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:12740440, PubMed:14500341, PubMed:9020151).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112#function"
                },
                {
                    "database": "PubMed",
                    "id": "9020151",
                    "url": "https://glygen.org/publication/PubMed/9020151"
                },
                {
                    "database": "PubMed",
                    "id": "14500341",
                    "url": "https://glygen.org/publication/PubMed/14500341"
                },
                {
                    "database": "PubMed",
                    "id": "12740440",
                    "url": "https://glygen.org/publication/PubMed/12740440"
                },
                {
                    "database": "PubMed",
                    "id": "22821884",
                    "url": "https://glygen.org/publication/PubMed/22821884"
                }
            ]
        },
        {
            "annotation": "Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma. Review article",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001123914",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
                },
                {
                    "database": "PubMed",
                    "id": "37665491",
                    "url": "https://glygen.org/publication/PubMed/37665491"
                }
            ]
        },
        {
            "annotation": "RAS gene mutations and histomorphometric measurements in oral squamous cell carcinoma.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001123914",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
                },
                {
                    "database": "PubMed",
                    "id": "37013448",
                    "url": "https://glygen.org/publication/PubMed/37013448"
                }
            ]
        },
        {
            "annotation": "This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008].",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001123914",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123914"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050469",
            "recommended_name": {
                "id": "DOID:0050469",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050469",
                "name": "Costello syndrome",
                "description": "A RASopathy characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays."
            },
            "synonyms": [
                {
                    "id": "DOID:0050469",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050469",
                    "name": "FCS SYNDROME",
                    "description": ""
                },
                {
                    "id": "DOID:0050469",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050469",
                    "name": "Faciocutaneoskeletal Syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "Costello syndrome",
                    "description": "Costello syndrome (CS) is a rare multisystemic disorder characterized by failure to thrive, short stature, developmental delay or intellectual disability, joint laxity, soft skin, and distinctive facial features. Cardiac and neurological involvement is common and there is an increased lifetime risk of certain tumors."
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "Costello syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "FCS syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "congenital myopathy with excess of muscle spindles",
                    "description": ""
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "faciocutaneoskeletal syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "CSTLO",
                    "description": ""
                },
                {
                    "id": "MONDO:0009026",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                    "name": "myopathy, congenital, with excess of muscle spindles",
                    "description": ""
                },
                {
                    "id": "MIM:218040",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/218040",
                    "name": "Congenital myopathy with excess of muscle spindles",
                    "description": "Congenital myopathy with excess of muscle spindles"
                }
            ],
            "evidence": [
                {
                    "id": "218040",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/218040"
                }
            ]
        },
        {
            "disease_id": "DOID:0111530",
            "recommended_name": {
                "id": "DOID:0111530",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111530",
                "name": "linear nevus sebaceous syndrome",
                "description": "A syndrome characterized by sebaceous nevi typically on the face and associated with variable ipsilateral abnormalities of the central nervous system, ocular anomalies, and skeletal defects that has_material_basis_in somatic mosaic mutations in the NRAS, HRAS, or KRAS genes on chromosomes 1p13.2, 11p15.5, or 12p12.1, respectively."
            },
            "synonyms": [
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "JNP",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "Jadassohn nevus phakomatosis",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "SFM syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "Schimmelpenning Feuerstein Mims syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "Schimmelpenning syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "Solomon syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "nevus sebaceus of Jadassohn",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "nevus sebaceus syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "organoid nevus phakomatosis",
                    "description": ""
                },
                {
                    "id": "DOID:0111530",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111530",
                    "name": "organoid nevus syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "linear nevus sebaceous syndrome",
                    "description": "Linear nevus sebaceous syndrome (LNSS) is characterized by the association of a large sebaceous nevus, usually appearing on the face or on the scalp, with a broad spectrum of abnormalities that may affect every organ system, including the central nervous system (brain neoplasms, hemimegalencephaly and lateral ventricle enlargement)."
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Nevus sebaceous of Jadassohn",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Nevus sebaceus of Jadassohn",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Nevus sebaceus syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Schimmelpenning syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Solomon syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "linear sebaceous Nevus",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "organoid Nevus",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "organoid nevus syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Epidermal Nevus syndrome, formerly",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "JNP",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Jadassohn Nevus phakomatosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Jadassohn nevus phakomatosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "SCHIMMELPENNING-FEUERSTEIN-MIMS syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "SFM",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "SFM syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Schimmelpenning Feuerstein Mims syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "Sfm syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "epidermal nevus syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "linear sebaceous Nevus syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "organoid Nevus phakomatosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "organoid nevus phakomatosis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "sebaceous Nevus syndrome, linear",
                    "description": ""
                },
                {
                    "id": "MONDO:0008097",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008097",
                    "name": "sebaceous nevus syndrome linear",
                    "description": ""
                },
                {
                    "id": "MIM:163200",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/163200",
                    "name": "Schimmelpenning-Feuerstein-Mims syndrome",
                    "description": "Schimmelpenning-Feuerstein-Mims syndrome"
                }
            ],
            "evidence": [
                {
                    "id": "163200",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/163200"
                }
            ]
        },
        {
            "disease_id": "DOID:11054",
            "recommended_name": {
                "id": "DOID:11054",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:11054",
                "name": "urinary bladder cancer",
                "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
            },
            "synonyms": [
                {
                    "id": "DOID:11054",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11054",
                    "name": "bladder cancer",
                    "description": ""
                },
                {
                    "id": "DOID:11054",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:11054",
                    "name": "tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder cancer",
                    "description": "A primary or metastatic malignant neoplasm involving the bladder."
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "tumor of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "tumour of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "bladder cancer, somatic",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "cancer of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant bladder tumour",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of the bladder",
                    "description": ""
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of the urinary bladder",
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                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm of urinary bladder",
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm, bladder",
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                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant neoplasm, urinary bladder",
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of bladder",
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                    "id": "MONDO:0001187",
                    "resource": "MONDO",
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                    "description": ""
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                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of the urinary bladder",
                    "description": ""
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor of urinary bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumor, urinary bladder",
                    "description": ""
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of bladder",
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
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                    "name": "malignant tumour of the bladder",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of the urinary bladder",
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant tumour of urinary bladder",
                    "description": ""
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "malignant urinary bladder tumor",
                    "description": ""
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                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
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                    "name": "malignant urinary bladder tumour",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder cancer",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant neoplasm",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant tumor",
                    "description": ""
                },
                {
                    "id": "MONDO:0001187",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                    "name": "urinary bladder malignant tumour",
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                },
                {
                    "id": "MIM:109800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/109800",
                    "name": "Bladder cancer",
                    "description": "Bladder cancer"
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            ],
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                    "id": "109800",
                    "database": "MIM",
                    "url": "https://www.omim.org/entry/109800"
                }
            ]
        },
        {
            "disease_id": "DOID:3962",
            "recommended_name": {
                "id": "DOID:3962",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:3962",
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                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3962",
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                },
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                    "id": "DOID:3962",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3962",
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                    "description": ""
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                {
                    "id": "DOID:3962",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3962",
                    "name": "Follicular carcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:3962",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3962",
                    "name": "Thyroid adenocarcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:3962",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:3962",
                    "name": "follicular thyroid carcinoma",
                    "description": ""
                },
                {
                    "id": "MONDO:0008566",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008566",
                    "name": "thyroid cancer, nonmedullary, 2",
                    "description": ""
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                {
                    "id": "MONDO:0008566",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008566",
                    "name": "thyroid cancer, nonmedullary, 2",
                    "description": ""
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                {
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                    "resource": "MONDO",
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                    "resource": "MONDO",
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                    "name": "thyroid cancer, nonmedullary, type 2",
                    "description": ""
                },
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                    "id": "MONDO:0008566",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008566",
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                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008566",
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                    "description": ""
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                {
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                    "resource": "MONDO",
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                },
                {
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                {
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                    "url": "https://monarchinitiative.org/disease/MONDO:0008566",
                    "name": "thyroid cancer, follicular",
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                    "url": "https://www.omim.org/entry/188470",
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    ],
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        {
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                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P01112"
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            "end_pos": 117,
            "subjects_tested": "0",
            "subjects_positive": "0",
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            "sequence_mut": "N",
            "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).",
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            "chr_pos": "533552",
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            "alt_nt": "G",
            "minor_allelic_frequency": "",
            "site_lbl": "K117",
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                            "description": ""
                        },
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
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                            "name": "melanoma and Non-melanoma skin cancer",
                            "description": ""
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                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
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                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
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                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
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                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
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                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
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                    ]
                },
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
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                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
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                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
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                            "name": "head and neck tumours",
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                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
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                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
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                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
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                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
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                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
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                            "description": ""
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                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
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                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                        {
                            "id": "MONDO:0016419",
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                        {
                            "id": "MONDO:0016419",
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                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
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                        {
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                            "resource": "MIM",
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                        {
                            "id": "DOID:11934",
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                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
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                        {
                            "id": "DOID:11934",
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                },
                {
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                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
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                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
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                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
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            ],
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        },
        {
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            ],
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                {
                    "disease_id": "DOID:11054",
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                    "synonyms": [
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                        {
                            "id": "DOID:11054",
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                        {
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                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:363",
                    "recommended_name": {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
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                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
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                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
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                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
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                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterus neoplasm",
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                        }
                    ]
                },
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
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                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
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                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
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                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
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                    ]
                }
            ],
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        },
        {
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                    "disease_id": "DOID:4159",
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                        "resource": "Disease Ontology",
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                        {
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                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:4159",
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                        },
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:4159",
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                        },
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:4159",
                            "name": "melanoma and Non-melanoma skin cancer",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
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                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
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                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
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                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
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                    ]
                },
                {
                    "disease_id": "DOID:363",
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                        "resource": "Disease Ontology",
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                            "id": "DOID:363",
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                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
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                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
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                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
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                    ]
                }
            ],
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        },
        {
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            ],
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                {
                    "disease_id": "DOID:11054",
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                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck tumours",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head/neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "tumor of head and neck",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast cancer",
                        "description": "A thoracic cancer that originates in the mammary gland."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant tumor of the breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:1781",
                    "recommended_name": {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid cancer",
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid gland cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "Thyroid gland neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant tumour of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid neoplasm",
                            "description": ""
                        }
                    ]
                }
            ],
            "keywords": [
                "biomuta",
                "somatic",
                "cancer",
                "disease"
            ]
        },
        {
            "evidence": [
                {
                    "id": "P01112",
                    "database": "BioMuta",
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P01112"
                }
            ],
            "glycoeffect": [],
            "start_pos": 13,
            "end_pos": 13,
            "subjects_tested": "0",
            "subjects_positive": "0",
            "frequency": "0.0",
            "sequence_org": "G",
            "sequence_mut": "V",
            "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
            "chr_id": "11",
            "chr_pos": "534285",
            "ref_nt": "C",
            "alt_nt": "A",
            "minor_allelic_frequency": "",
            "site_lbl": "G13",
            "disease": [
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck tumours",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head/neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "tumor of head and neck",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                }
            ],
            "keywords": [
                "biomuta",
                "somatic",
                "cancer",
                "disease"
            ]
        },
        {
            "evidence": [
                {
                    "id": "P01112",
                    "database": "BioMuta",
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P01112"
                }
            ],
            "glycoeffect": [],
            "start_pos": 61,
            "end_pos": 61,
            "subjects_tested": "0",
            "subjects_positive": "0",
            "frequency": "0.0",
            "sequence_org": "Q",
            "sequence_mut": "K",
            "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (5).",
            "chr_id": "11",
            "chr_pos": "533875",
            "ref_nt": "G",
            "alt_nt": "T",
            "minor_allelic_frequency": "",
            "site_lbl": "Q61",
            "disease": [
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:4159",
                    "recommended_name": {
                        "id": "DOID:4159",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:4159",
                        "name": "skin cancer",
                        "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:4159",
                            "name": "CA - skin cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:4159",
                            "name": "malignant neoplasm of skin",
                            "description": ""
                        },
                        {
                            "id": "DOID:4159",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:4159",
                            "name": "melanoma and Non-melanoma skin cancer",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:1781",
                    "recommended_name": {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid cancer",
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid gland cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "Thyroid gland neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant tumour of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid neoplasm",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:10283",
                    "recommended_name": {
                        "id": "DOID:10283",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10283",
                        "name": "prostate cancer",
                        "description": "A male reproductive organ cancer that is located_in the prostate."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "NGP - new growth of prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "malignant tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, type 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "HPC9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "EHBP1 familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "familial prostate cancer caused by mutation in EHBP1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, type 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "HPC12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, type 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "HPC5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, type 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, susceptibility to, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "HPC3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, type 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, susceptibility to, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "HPC4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, on chromosome 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "MSMB familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "familial prostate cancer caused by mutation in MSMB",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, type 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "HPC13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, type 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "HPC8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "predisposing for prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, type 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "HPC6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "HPC10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate carcinoma",
                            "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, hereditary",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "HPC7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer aggressiveness",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "RNASEL familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "familial prostate cancer caused by mutation in RNASEL",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, type 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "HPC1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "Prca1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "HPC11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "HPC14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "HPC15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "HPCX1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer susceptibility, X-linked",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "HPCX2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MIM:611868",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611868",
                            "name": "Prostate cancer, hereditary, 12",
                            "description": "Prostate cancer, hereditary, 12"
                        },
                        {
                            "id": "MIM:611928",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611928",
                            "name": "Prostate cancer, hereditary, 13",
                            "description": "Prostate cancer, hereditary, 13"
                        },
                        {
                            "id": "MIM:176807",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/176807",
                            "name": "Prostate cancer",
                            "description": "Prostate cancer"
                        },
                        {
                            "id": "MIM:601518",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/601518",
                            "name": "Prostate cancer, hereditary, 1",
                            "description": "Prostate cancer, hereditary, 1"
                        },
                        {
                            "id": "MIM:611955",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611955",
                            "name": "Prostate cancer, hereditary, 11",
                            "description": "Prostate cancer, hereditary, 11"
                        }
                    ]
                }
            ],
            "keywords": [
                "biomuta",
                "somatic",
                "cancer",
                "disease"
            ]
        },
        {
            "evidence": [
                {
                    "id": "P01112",
                    "database": "BioMuta",
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P01112"
                }
            ],
            "glycoeffect": [],
            "start_pos": 61,
            "end_pos": 61,
            "subjects_tested": "0",
            "subjects_positive": "0",
            "frequency": "0.0",
            "sequence_org": "Q",
            "sequence_mut": "L",
            "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4). In dbSNP: rs121913233.",
            "chr_id": "11",
            "chr_pos": "533874",
            "ref_nt": "T",
            "alt_nt": "A",
            "minor_allelic_frequency": "",
            "site_lbl": "Q61",
            "disease": [
                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast cancer",
                        "description": "A thoracic cancer that originates in the mammary gland."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant tumor of the breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck tumours",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head/neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "tumor of head and neck",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                }
            ],
            "keywords": [
                "biomuta",
                "somatic",
                "cancer",
                "disease"
            ]
        },
        {
            "evidence": [
                {
                    "id": "P01112",
                    "database": "BioMuta",
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/P01112"
                }
            ],
            "glycoeffect": [],
            "start_pos": 61,
            "end_pos": 61,
            "subjects_tested": "0",
            "subjects_positive": "0",
            "frequency": "0.0",
            "sequence_org": "Q",
            "sequence_mut": "R",
            "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3). In dbSNP: rs121913233.",
            "chr_id": "11",
            "chr_pos": "533874",
            "ref_nt": "T",
            "alt_nt": "C",
            "minor_allelic_frequency": "",
            "site_lbl": "Q61",
            "disease": [
                {
                    "disease_id": "DOID:1781",
                    "recommended_name": {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid cancer",
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid gland cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "Thyroid gland neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant tumour of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid neoplasm",
                            "description": ""
                        }
                    ]
                },
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                },
                {
                    "disease_id": "DOID:10283",
                    "recommended_name": {
                        "id": "DOID:10283",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10283",
                        "name": "prostate cancer",
                        "description": "A male reproductive organ cancer that is located_in the prostate."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "NGP - new growth of prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "malignant tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostate neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "prostatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
                            "name": "tumor of the prostate",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, type 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "HPC9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "EHBP1 familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "familial prostate cancer caused by mutation in EHBP1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, type 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "HPC12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, type 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "HPC5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, type 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, susceptibility to, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "HPC3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, type 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, susceptibility to, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "HPC4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, on chromosome 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "MSMB familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "familial prostate cancer caused by mutation in MSMB",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, type 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "HPC13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, type 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "HPC8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "predisposing for prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, type 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "HPC6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "HPC10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate carcinoma",
                            "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, hereditary",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "HPC7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer aggressiveness",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "RNASEL familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "familial prostate cancer caused by mutation in RNASEL",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, type 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "HPC1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "Prca1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "HPC11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "HPC14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "HPC15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "HPCX1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer susceptibility, X-linked",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "HPCX2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MIM:611868",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611868",
                            "name": "Prostate cancer, hereditary, 12",
                            "description": "Prostate cancer, hereditary, 12"
                        },
                        {
                            "id": "MIM:611928",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611928",
                            "name": "Prostate cancer, hereditary, 13",
                            "description": "Prostate cancer, hereditary, 13"
                        },
                        {
                            "id": "MIM:176807",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/176807",
                            "name": "Prostate cancer",
                            "description": "Prostate cancer"
                        },
                        {
                            "id": "MIM:601518",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/601518",
                            "name": "Prostate cancer, hereditary, 1",
                            "description": "Prostate cancer, hereditary, 1"
                        },
                        {
                            "id": "MIM:611955",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611955",
                            "name": "Prostate cancer, hereditary, 11",
                            "description": "Prostate cancer, hereditary, 11"
                        }
                    ]
                }
            ],
            "keywords": [
                "biomuta",
                "somatic",
                "cancer",
                "disease"
            ]
        },
        {
            "evidence": [
                {
                    "id": "rs1851272986",
                    "database": "dbSNP",
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1851272986"
                }
            ],
            "glycoeffect": [
                "n-glyco-sequon-gain",
                "n-glyco-sequon-loss",
                "o-glyco-site-loss"
            ],
            "start_pos": 87,
            "end_pos": 87,
            "sequence_org": "T",
            "sequence_mut": "N",
            "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TKS->NKS).",
            "chr_id": "11",
            "chr_pos": "533796",
            "ref_nt": "T",
            "alt_nt": "null",
            "minor_allelic_frequency": "",
            "site_lbl": "T87",
            "disease": [
                {
                    "disease_id": "DOID:0050469",
                    "recommended_name": {
                        "id": "DOID:0050469",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:0050469",
                        "name": "Costello syndrome",
                        "description": "A RASopathy characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:0050469",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:0050469",
                            "name": "FCS SYNDROME",
                            "description": ""
                        },
                        {
                            "id": "DOID:0050469",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:0050469",
                            "name": "Faciocutaneoskeletal Syndrome",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "Costello syndrome",
                            "description": "Costello syndrome (CS) is a rare multisystemic disorder characterized by failure to thrive, short stature, developmental delay or intellectual disability, joint laxity, soft skin, and distinctive facial features. Cardiac and neurological involvement is common and there is an increased lifetime risk of certain tumors."
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "Costello syndrome",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "FCS syndrome",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "congenital myopathy with excess of muscle spindles",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "faciocutaneoskeletal syndrome",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "CSTLO",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0009026",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0009026",
                            "name": "myopathy, congenital, with excess of muscle spindles",
                            "description": ""
                        },
                        {
                            "id": "MIM:218040",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/218040",
                            "name": "Congenital myopathy with excess of muscle spindles",
                            "description": "Congenital myopathy with excess of muscle spindles"
                        }
                    ]
                }
            ],
            "keywords": [
                "ebi",
                "germline",
                "disease"
            ]
        }
    ],
    "mutagenesis": [
        {
            "start_pos": 118,
            "end_pos": 118,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Abolishes S-nitrosylation. No stimulation of guanine nucleotide exchange.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "9020151",
                    "url": "https://glygen.org/publication/PubMed/9020151"
                },
                {
                    "database": "PubMed",
                    "id": "12740440",
                    "url": "https://glygen.org/publication/PubMed/12740440"
                }
            ]
        },
        {
            "start_pos": 119,
            "end_pos": 119,
            "sequence_org": "D",
            "sequence_mut": "N",
            "comment": "Loss of GTP-binding activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "3088563",
                    "url": "https://glygen.org/publication/PubMed/3088563"
                }
            ]
        },
        {
            "start_pos": 144,
            "end_pos": 144,
            "sequence_org": "T",
            "sequence_mut": "I",
            "comment": "GTP-binding activity reduced by factor of 25.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "3088563",
                    "url": "https://glygen.org/publication/PubMed/3088563"
                }
            ]
        },
        {
            "start_pos": 164,
            "end_pos": 165,
            "sequence_org": "RQ",
            "sequence_mut": "AV",
            "comment": "Loss of GTP-binding activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "3011420",
                    "url": "https://glygen.org/publication/PubMed/3011420"
                }
            ]
        },
        {
            "start_pos": 167,
            "end_pos": 185,
            "sequence_org": "KLRKLNPPDESGPGCMSCK",
            "sequence_mut": "RLRRLNPPDESGPGCMSCR",
            "comment": "In H-Ras-3KR mutant; decreased fatty-acylation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "29239724",
                    "url": "https://glygen.org/publication/PubMed/29239724"
                }
            ]
        },
        {
            "start_pos": 170,
            "end_pos": 170,
            "sequence_org": "K",
            "sequence_mut": "R",
            "comment": "Increased Ras signaling due to impaired ubiquitination.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "30442762",
                    "url": "https://glygen.org/publication/PubMed/30442762"
                }
            ]
        },
        {
            "start_pos": 17,
            "end_pos": 17,
            "sequence_org": "S",
            "sequence_mut": "N",
            "comment": "Dominant negative. Prevents PLCE1 EGF-induced recruitment to plasma membrane. No effect on subcellular location of isoform 2.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "14500341",
                    "url": "https://glygen.org/publication/PubMed/14500341"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 181,
            "end_pos": 181,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Exclusively localized in Golgi. Non-specifically localized on all endomembranes; when associated with S-184.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "8626715",
                    "url": "https://glygen.org/publication/PubMed/8626715"
                },
                {
                    "database": "PubMed",
                    "id": "15705808",
                    "url": "https://glygen.org/publication/PubMed/15705808"
                }
            ]
        },
        {
            "start_pos": 184,
            "end_pos": 184,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Loss of S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine stimulation of Ras-GTPase activity. Mainly localized in Golgi. Non-specifically localized on all endomembranes; when associated with S-181.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "8626715",
                    "url": "https://glygen.org/publication/PubMed/8626715"
                },
                {
                    "database": "PubMed",
                    "id": "12684535",
                    "url": "https://glygen.org/publication/PubMed/12684535"
                },
                {
                    "database": "PubMed",
                    "id": "15705808",
                    "url": "https://glygen.org/publication/PubMed/15705808"
                }
            ]
        },
        {
            "start_pos": 26,
            "end_pos": 26,
            "sequence_org": "N",
            "sequence_mut": "G",
            "comment": "Loss of interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 29,
            "end_pos": 29,
            "sequence_org": "V",
            "sequence_mut": "A",
            "comment": "No effect on interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 32,
            "end_pos": 32,
            "sequence_org": "Y",
            "sequence_mut": "F",
            "comment": "Loss of interaction and recruitment to plasma membrane of PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 34,
            "end_pos": 34,
            "sequence_org": "P",
            "sequence_mut": "G",
            "comment": "No effect on interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 35,
            "end_pos": 35,
            "sequence_org": "T",
            "sequence_mut": "S",
            "comment": "Loss of interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 37,
            "end_pos": 37,
            "sequence_org": "E",
            "sequence_mut": "G",
            "comment": "No effect on interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 38,
            "end_pos": 38,
            "sequence_org": "D",
            "sequence_mut": "N",
            "comment": "No effect on interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 39,
            "end_pos": 39,
            "sequence_org": "S",
            "sequence_mut": "C",
            "comment": "No effect on interaction with PLCE1; when associated with V-12.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "11022048",
                    "url": "https://glygen.org/publication/PubMed/11022048"
                }
            ]
        },
        {
            "start_pos": 59,
            "end_pos": 59,
            "sequence_org": "A",
            "sequence_mut": "T",
            "comment": "Loss of GTPase activity and creation of an autophosphorylation site.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                }
            ]
        },
        {
            "start_pos": 61,
            "end_pos": 61,
            "sequence_org": "Q",
            "sequence_mut": "I",
            "comment": "Moderately increased transformation of cultured cell lines.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "18073111",
                    "url": "https://glygen.org/publication/PubMed/18073111"
                }
            ]
        },
        {
            "start_pos": 61,
            "end_pos": 61,
            "sequence_org": "Q",
            "sequence_mut": "V",
            "comment": "Strongly increased transformation of cultured cell lines.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "18073111",
                    "url": "https://glygen.org/publication/PubMed/18073111"
                }
            ]
        },
        {
            "start_pos": 83,
            "end_pos": 83,
            "sequence_org": "A",
            "sequence_mut": "T",
            "comment": "GTP-binding activity reduced by factor of 30.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "3088563",
                    "url": "https://glygen.org/publication/PubMed/3088563"
                }
            ]
        }
    ],
    "expression_tissue": [
        {
            "tissue": {
                "name": "Adult mammalian kidney",
                "namespace": "UBERON",
                "id": "0000082",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000082"
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            "score": "84.91",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Oral cavity",
                "namespace": "UBERON",
                "id": "0000167",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000167"
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            "score": "88.04",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Stomach",
                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "score": "84.8",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Uterus",
                "namespace": "UBERON",
                "id": "0000995",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000995"
            },
            "score": "78.42",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Esophagus",
                "namespace": "UBERON",
                "id": "0001043",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043"
            },
            "score": "96.22",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Rectum",
                "namespace": "UBERON",
                "id": "0001052",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001052"
            },
            "score": "87.93",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Colon",
                "namespace": "UBERON",
                "id": "0001155",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155"
            },
            "score": "74.91",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Urinary bladder",
                "namespace": "UBERON",
                "id": "0001255",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255"
            },
            "score": "88.75",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
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            ]
        },
        {
            "tissue": {
                "name": "Thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "score": "93.96",
            "present": "HIGH",
            "evidence": [
                {
                    "database": "Bgee",
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                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
        },
        {
            "tissue": {
                "name": "Lung",
                "namespace": "UBERON",
                "id": "0002048",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048"
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            "score": "71.71",
            "present": "MEDIUM",
            "evidence": [
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                    "database": "Bgee",
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            "present": "HIGH",
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            ]
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        {
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            "score": "97.86",
            "present": "HIGH",
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                    "database": "Bgee",
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                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
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        {
            "tissue": {
                "name": "Thoracic mammary gland",
                "namespace": "UBERON",
                "id": "0005200",
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            "score": "96.15",
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                    "id": "ENSG00000174775",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174775"
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            ]
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    ],
    "expression_disease": [
        {
            "significant": "Yes",
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                    "database": "BioXpress",
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                    "synonyms": [
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                            "name": "NGP - new growth of prostate",
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                        {
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                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
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                            "description": ""
                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10283",
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                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
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                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
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                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
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                        },
                        {
                            "id": "DOID:10283",
                            "resource": "Disease Ontology",
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                            "name": "tumor of the prostate",
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                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "prostate cancer, hereditary, type 9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012597",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012597",
                            "name": "HPC9",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "EHBP1 familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "familial prostate cancer caused by mutation in EHBP1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "prostate cancer, hereditary, type 12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012741",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012741",
                            "name": "HPC12",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "prostate cancer, hereditary, type 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012244",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012244",
                            "name": "HPC5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, hereditary, type 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "prostate cancer, susceptibility to, 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012093",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012093",
                            "name": "HPC3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, type 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, susceptibility to, 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "HPC4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012094",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012094",
                            "name": "prostate cancer, hereditary, on chromosome 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "MSMB familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "familial prostate cancer caused by mutation in MSMB",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "prostate cancer, hereditary, type 13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012758",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012758",
                            "name": "HPC13",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, hereditary, type 8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "HPC8",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "predisposing for prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011270",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011270",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, hereditary, type 6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "HPC6",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012300",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012300",
                            "name": "prostate cancer, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "HPC10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012620",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012620",
                            "name": "prostate cancer, hereditary, 10",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate carcinoma",
                            "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "hereditary prostate carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0023122",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0023122",
                            "name": "prostate cancer, hereditary",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "HPC7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer, hereditary, 7",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012470",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012470",
                            "name": "prostate cancer aggressiveness",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "RNASEL familial prostate cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "familial prostate cancer caused by mutation in RNASEL",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "prostate cancer, hereditary, type 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "HPC1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0011098",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0011098",
                            "name": "Prca1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "HPC11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012768",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012768",
                            "name": "prostate cancer, hereditary, 11",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "HPC14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012769",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012769",
                            "name": "prostate cancer, hereditary, 14",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "HPC15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012770",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012770",
                            "name": "prostate cancer, hereditary, 15",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "HPCX1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer, hereditary, X-linked 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010257",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010257",
                            "name": "prostate cancer susceptibility, X-linked",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "HPCX2",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0010405",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0010405",
                            "name": "prostate cancer, hereditary, X-linked 2",
                            "description": ""
                        },
                        {
                            "id": "MIM:611868",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611868",
                            "name": "Prostate cancer, hereditary, 12",
                            "description": "Prostate cancer, hereditary, 12"
                        },
                        {
                            "id": "MIM:611928",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611928",
                            "name": "Prostate cancer, hereditary, 13",
                            "description": "Prostate cancer, hereditary, 13"
                        },
                        {
                            "id": "MIM:176807",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/176807",
                            "name": "Prostate cancer",
                            "description": "Prostate cancer"
                        },
                        {
                            "id": "MIM:601518",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/601518",
                            "name": "Prostate cancer, hereditary, 1",
                            "description": "Prostate cancer, hereditary, 1"
                        },
                        {
                            "id": "MIM:611955",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/611955",
                            "name": "Prostate cancer, hereditary, 11",
                            "description": "Prostate cancer, hereditary, 11"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "down",
            "name": "Stomach cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:10534",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:10534",
                    "recommended_name": {
                        "id": "DOID:10534",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:10534",
                        "name": "stomach cancer",
                        "description": "A gastrointestinal system cancer that is located_in the stomach."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:10534",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "name": "gastric cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:10534",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:10534",
                            "name": "gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the stomach."
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "Ca lesser curvature - stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "cancer of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer risk after h. pylori infection",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant gastric tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant stomach neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of greater curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumor of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of greater curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of lesser curve of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant tumour of the stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "stomach cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "Ca body - stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "ca greater curvature of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "malignant neoplasm of body of stomach",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001056",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001056",
                            "name": "gastric cancer, intestinal",
                            "description": ""
                        },
                        {
                            "id": "MIM:613659",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/613659",
                            "name": "Gastric cancer",
                            "description": "Gastric cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Urinary bladder cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:11054",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:11054",
                    "recommended_name": {
                        "id": "DOID:11054",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11054",
                        "name": "urinary bladder cancer",
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:11054",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11054",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the bladder."
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "bladder cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "cancer of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant neoplasm, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumor, urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of the urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant tumour of urinary bladder",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "malignant urinary bladder tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0001187",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0001187",
                            "name": "urinary bladder malignant tumour",
                            "description": ""
                        },
                        {
                            "id": "MIM:109800",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/109800",
                            "name": "Bladder cancer",
                            "description": "Bladder cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Head and neck cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:11934",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:11934",
                    "recommended_name": {
                        "id": "DOID:11934",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:11934",
                        "name": "head and neck cancer",
                        "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head and neck tumours",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "head/neck neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:11934",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:11934",
                            "name": "tumor of head and neck",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Lung cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1324",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1324",
                    "recommended_name": {
                        "id": "DOID:1324",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "synonyms": [
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "LNCR1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012159",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012159",
                            "name": "lung cancer susceptibility 1",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "LNCR3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "lung cancer susceptibility 3",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012942",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012942",
                            "name": "adenocarcinoma of lung, susceptibility to",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "LNCR4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0012955",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0012955",
                            "name": "lung cancer susceptibility 4",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "LNCR5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0013631",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0013631",
                            "name": "lung cancer susceptibility 5",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": "A malignant neoplasm involving the lung."
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "adenocarcinoma of lung, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "cancer of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant lung tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant neoplasm of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumor of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "malignant tumour of the lung",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "Nonsmall cell lung cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "alveolar cell carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung cancer, protection against",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0008903",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0008903",
                            "name": "lung neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MIM:211980",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/211980",
                            "name": "Lung cancer",
                            "description": "Lung cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Breast cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1612",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1612",
                    "recommended_name": {
                        "id": "DOID:1612",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1612",
                        "name": "breast cancer",
                        "description": "A thoracic cancer that originates in the mammary gland."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "breast tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant neoplasm of breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "malignant tumor of the breast",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "mammary tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:1612",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1612",
                            "name": "primary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, lobular, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, protection against, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "familial cancer of the breast",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "hereditary breast carcinoma",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0016419",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0016419",
                            "name": "breast cancer, familial Male",
                            "description": ""
                        },
                        {
                            "id": "MIM:114480",
                            "resource": "MIM",
                            "url": "https://www.omim.org/entry/114480",
                            "name": "Breast cancer",
                            "description": "Breast cancer"
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Thyroid cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:1781",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:1781",
                    "recommended_name": {
                        "id": "DOID:1781",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:1781",
                        "name": "thyroid cancer",
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid gland cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "Thyroid gland neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "malignant tumour of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "neoplasm of thyroid gland",
                            "description": ""
                        },
                        {
                            "id": "DOID:1781",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:1781",
                            "name": "thyroid neoplasm",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Kidney cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:263",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:263",
                    "recommended_name": {
                        "id": "DOID:263",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:263",
                        "name": "kidney cancer",
                        "description": "A urinary system cancer that is located_in the kidney."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant neoplasm of kidney except pelvis",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "malignant tumour of kidney",
                            "description": ""
                        },
                        {
                            "id": "DOID:263",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:263",
                            "name": "renal cancer",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Liver cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:3571",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:3571",
                    "recommended_name": {
                        "id": "DOID:3571",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:3571",
                        "name": "liver cancer",
                        "description": "A hepatobiliary system cancer that is located_in the liver."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Ca liver - primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "Resectable malignant neoplasm of Liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "hepatic neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant hepato-biliary neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, primary",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant tumor of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "non-resectable primary hepatic malignant neoplasm",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary liver cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "primary malignant neoplasm of liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "resectable malignant neoplasm of the liver",
                            "description": ""
                        },
                        {
                            "id": "DOID:3571",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:3571",
                            "name": "malignant neoplasm of liver, not specified as primary or secondary",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "Yes",
            "trend": "up",
            "name": "Uterine cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:363",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:363",
                    "recommended_name": {
                        "id": "DOID:363",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:363",
                        "name": "uterine cancer",
                        "description": "A female reproductive organ cancer that is located_in the uterus."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "CA - cancer of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "Tumour of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "malignant uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "neoplasm of uterus",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterine tumor",
                            "description": ""
                        },
                        {
                            "id": "DOID:363",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:363",
                            "name": "uterus neoplasm",
                            "description": ""
                        }
                    ]
                }
            ]
        },
        {
            "significant": "No",
            "trend": "up",
            "name": "Esophageal cancer [DO disease name]",
            "url": "http://disease-ontology.org/term/DOID:5041",
            "evidence": [
                {
                    "database": "BioXpress",
                    "id": "P01112",
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01112"
                }
            ],
            "disease": [
                {
                    "disease_id": "DOID:5041",
                    "recommended_name": {
                        "id": "DOID:5041",
                        "resource": "Disease Ontology",
                        "url": "http://disease-ontology.org/term/DOID:5041",
                        "name": "esophageal cancer",
                        "description": "A gastrointestinal system cancer that is located_in the esophagus."
                    },
                    "synonyms": [
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "Ca lower third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "Ca middle third oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "esophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of distal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of lower third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of middle third of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of proximal third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant neoplasm of upper third esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of Distal Third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of Proximal Third of esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of abdominal esophagus",
                            "description": ""
                        },
                        {
                            "id": "DOID:5041",
                            "resource": "Disease Ontology",
                            "url": "http://disease-ontology.org/term/DOID:5041",
                            "name": "malignant tumor of the middle Third of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer",
                            "description": "A primary or metastatic malignant neoplasm involving the esophagus."
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "cancer of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "cancer of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal cancer, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal carcinoma, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophageal squamous cell carcinoma, somatic",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "esophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophageal tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophagus neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant esophagus tumor",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant neoplasm of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant oesophagus neoplasm",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant oesophagus tumour",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumor of the esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "malignant tumour of the oesophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "oesophagus cancer",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca lower third esophagus",
                            "description": ""
                        },
                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
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                            "description": ""
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                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
                            "url": "https://monarchinitiative.org/disease/MONDO:0007576",
                            "name": "Ca middle third esophagus",
                            "description": ""
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                        {
                            "id": "MONDO:0007576",
                            "resource": "MONDO",
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                            "id": "MONDO:0007576",
                            "resource": "MONDO",
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                            "id": "MONDO:0007576",
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                            "id": "MONDO:0007576",
                            "resource": "MONDO",
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                            "id": "MONDO:0007576",
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                            "id": "MONDO:0007576",
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                            "id": "MONDO:0007576",
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                            "id": "MONDO:0007576",
                            "resource": "MONDO",
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                        {
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            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-375165",
            "resource": "Reactome",
            "description": "NCAM signaling for neurite out-growth"
        },
        {
            "id": "R-HSA-3928662",
            "name": "EPHB-mediated forward signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928662",
            "resource": "Reactome",
            "description": "EPHB-mediated forward signaling"
        },
        {
            "id": "R-HSA-442982",
            "name": "Ras activation upon Ca2+ influx through NMDA receptor",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-442982",
            "resource": "Reactome",
            "description": "Ras activation upon Ca2+ influx through NMDA receptor"
        },
        {
            "id": "R-HSA-5218921",
            "name": "VEGFR2 mediated cell proliferation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5218921",
            "resource": "Reactome",
            "description": "VEGFR2 mediated cell proliferation"
        },
        {
            "id": "R-HSA-5621575",
            "name": "CD209 (DC-SIGN) signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621575",
            "resource": "Reactome",
            "description": "CD209 (DC-SIGN) signaling"
        },
        {
            "id": "R-HSA-5637810",
            "name": "Constitutive Signaling by EGFRvIII",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5637810",
            "resource": "Reactome",
            "description": "Constitutive Signaling by EGFRvIII"
        },
        {
            "id": "R-HSA-5654688",
            "name": "SHC-mediated cascade:FGFR1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654688",
            "resource": "Reactome",
            "description": "SHC-mediated cascade:FGFR1"
        },
        {
            "id": "R-HSA-5654693",
            "name": "FRS-mediated FGFR1 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654693",
            "resource": "Reactome",
            "description": "FRS-mediated FGFR1 signaling"
        },
        {
            "id": "R-HSA-5654699",
            "name": "SHC-mediated cascade:FGFR2",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654699",
            "resource": "Reactome",
            "description": "SHC-mediated cascade:FGFR2"
        },
        {
            "id": "R-HSA-5654700",
            "name": "FRS-mediated FGFR2 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654700",
            "resource": "Reactome",
            "description": "FRS-mediated FGFR2 signaling"
        },
        {
            "id": "R-HSA-5654704",
            "name": "SHC-mediated cascade:FGFR3",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654704",
            "resource": "Reactome",
            "description": "SHC-mediated cascade:FGFR3"
        },
        {
            "id": "R-HSA-5654706",
            "name": "FRS-mediated FGFR3 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654706",
            "resource": "Reactome",
            "description": "FRS-mediated FGFR3 signaling"
        },
        {
            "id": "R-HSA-5654712",
            "name": "FRS-mediated FGFR4 signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654712",
            "resource": "Reactome",
            "description": "FRS-mediated FGFR4 signaling"
        },
        {
            "id": "R-HSA-5654719",
            "name": "SHC-mediated cascade:FGFR4",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654719",
            "resource": "Reactome",
            "description": "SHC-mediated cascade:FGFR4"
        },
        {
            "id": "R-HSA-5655253",
            "name": "Signaling by FGFR2 in disease",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655253",
            "resource": "Reactome",
            "description": "Signaling by FGFR2 in disease"
        },
        {
            "id": "R-HSA-5655291",
            "name": "Signaling by FGFR4 in disease",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655291",
            "resource": "Reactome",
            "description": "Signaling by FGFR4 in disease"
        },
        {
            "id": "R-HSA-5655302",
            "name": "Signaling by FGFR1 in disease",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655302",
            "resource": "Reactome",
            "description": "Signaling by FGFR1 in disease"
        },
        {
            "id": "R-HSA-5655332",
            "name": "Signaling by FGFR3 in disease",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655332",
            "resource": "Reactome",
            "description": "Signaling by FGFR3 in disease"
        },
        {
            "id": "R-HSA-5658442",
            "name": "Regulation of RAS by GAPs",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5658442",
            "resource": "Reactome",
            "description": "Regulation of RAS by GAPs"
        },
        {
            "id": "R-HSA-5673000",
            "name": "RAF activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673000",
            "resource": "Reactome",
            "description": "RAF activation"
        },
        {
            "id": "R-HSA-5673001",
            "name": "RAF/MAP kinase cascade",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5673001",
            "resource": "Reactome",
            "description": "RAF/MAP kinase cascade"
        },
        {
            "id": "R-HSA-5674135",
            "name": "MAP2K and MAPK activation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674135",
            "resource": "Reactome",
            "description": "MAP2K and MAPK activation"
        },
        {
            "id": "R-HSA-5675221",
            "name": "Negative regulation of MAPK pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675221",
            "resource": "Reactome",
            "description": "Negative regulation of MAPK pathway"
        },
        {
            "id": "R-HSA-6802946",
            "name": "Signaling by moderate kinase activity BRAF mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802946",
            "resource": "Reactome",
            "description": "Signaling by moderate kinase activity BRAF mutants"
        },
        {
            "id": "R-HSA-6802948",
            "name": "Signaling by high-kinase activity BRAF mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802948",
            "resource": "Reactome",
            "description": "Signaling by high-kinase activity BRAF mutants"
        },
        {
            "id": "R-HSA-6802952",
            "name": "Signaling by BRAF and RAF1 fusions",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802952",
            "resource": "Reactome",
            "description": "Signaling by BRAF and RAF1 fusions"
        },
        {
            "id": "R-HSA-6802953",
            "name": "RAS signaling downstream of NF1 loss-of-function variants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802953",
            "resource": "Reactome",
            "description": "RAS signaling downstream of NF1 loss-of-function variants"
        },
        {
            "id": "R-HSA-6802955",
            "name": "Paradoxical activation of RAF signaling by kinase inactive BRAF",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802955",
            "resource": "Reactome",
            "description": "Paradoxical activation of RAF signaling by kinase inactive BRAF"
        },
        {
            "id": "R-HSA-74751",
            "name": "Insulin receptor signalling cascade",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-74751",
            "resource": "Reactome",
            "description": "Insulin receptor signalling cascade"
        },
        {
            "id": "R-HSA-8849471",
            "name": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8849471",
            "resource": "Reactome",
            "description": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"
        },
        {
            "id": "R-HSA-8851805",
            "name": "MET activates RAS signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8851805",
            "resource": "Reactome",
            "description": "MET activates RAS signaling"
        },
        {
            "id": "R-HSA-9026519",
            "name": "Activated NTRK2 signals through RAS",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9026519",
            "resource": "Reactome",
            "description": "Activated NTRK2 signals through RAS"
        },
        {
            "id": "R-HSA-9027284",
            "name": "Erythropoietin activates RAS",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9027284",
            "resource": "Reactome",
            "description": "Erythropoietin activates RAS"
        },
        {
            "id": "R-HSA-9028731",
            "name": "Activated NTRK2 signals through FRS2 and FRS3",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9028731",
            "resource": "Reactome",
            "description": "Activated NTRK2 signals through FRS2 and FRS3"
        },
        {
            "id": "R-HSA-9034864",
            "name": "Activated NTRK3 signals through RAS",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9034864",
            "resource": "Reactome",
            "description": "Activated NTRK3 signals through RAS"
        },
        {
            "id": "R-HSA-9607240",
            "name": "FLT3 Signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9607240",
            "resource": "Reactome",
            "description": "FLT3 Signaling"
        },
        {
            "id": "R-HSA-9634285",
            "name": "Constitutive Signaling by Overexpressed ERBB2",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634285",
            "resource": "Reactome",
            "description": "Constitutive Signaling by Overexpressed ERBB2"
        },
        {
            "id": "R-HSA-9634635",
            "name": "Estrogen-stimulated signaling through PRKCZ",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634635",
            "resource": "Reactome",
            "description": "Estrogen-stimulated signaling through PRKCZ"
        },
        {
            "id": "R-HSA-9648002",
            "name": "RAS processing",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002",
            "resource": "Reactome",
            "description": "RAS processing"
        },
        {
            "id": "R-HSA-9649948",
            "name": "Signaling downstream of RAS mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649948",
            "resource": "Reactome",
            "description": "Signaling downstream of RAS mutants"
        },
        {
            "id": "R-HSA-9656223",
            "name": "Signaling by RAF1 mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656223",
            "resource": "Reactome",
            "description": "Signaling by RAF1 mutants"
        },
        {
            "id": "R-HSA-9664565",
            "name": "Signaling by ERBB2 KD Mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664565",
            "resource": "Reactome",
            "description": "Signaling by ERBB2 KD Mutants"
        },
        {
            "id": "R-HSA-9665348",
            "name": "Signaling by ERBB2 ECD mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665348",
            "resource": "Reactome",
            "description": "Signaling by ERBB2 ECD mutants"
        },
        {
            "id": "R-HSA-9665686",
            "name": "Signaling by ERBB2 TMD/JMD mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665686",
            "resource": "Reactome",
            "description": "Signaling by ERBB2 TMD/JMD mutants"
        },
        {
            "id": "R-HSA-9670439",
            "name": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670439",
            "resource": "Reactome",
            "description": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants"
        },
        {
            "id": "R-HSA-9673767",
            "name": "Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673767",
            "resource": "Reactome",
            "description": "Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants"
        },
        {
            "id": "R-HSA-9673770",
            "name": "Signaling by PDGFRA extracellular domain mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9673770",
            "resource": "Reactome",
            "description": "Signaling by PDGFRA extracellular domain mutants"
        },
        {
            "id": "R-HSA-9703465",
            "name": "Signaling by FLT3 fusion proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9703465",
            "resource": "Reactome",
            "description": "Signaling by FLT3 fusion proteins"
        },
        {
            "id": "R-HSA-9703648",
            "name": "Signaling by FLT3 ITD and TKD mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9703648",
            "resource": "Reactome",
            "description": "Signaling by FLT3 ITD and TKD mutants"
        },
        {
            "id": "R-HSA-9753510",
            "name": "Signaling by RAS GAP mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9753510",
            "resource": "Reactome",
            "description": "Signaling by RAS GAP mutants"
        },
        {
            "id": "R-HSA-9753512",
            "name": "Signaling by RAS GTPase mutants",
            "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9753512",
            "resource": "Reactome",
            "description": "Signaling by RAS GTPase mutants"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P20171-1",
            "protein_name": "GTPase HRas",
            "gene_name": "Hras",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS",
                "length": 189
            },
            "evidence": [
                {
                    "id": "45926332",
                    "url": "http://www.informatics.jax.org/homology/45926332",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q61411-1",
            "protein_name": "GTPase HRas",
            "gene_name": "Hras",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS",
                "length": 189
            },
            "evidence": [
                {
                    "id": "45926332",
                    "url": "http://www.informatics.jax.org/homology/45926332",
                    "database": "MGI"
                },
                {
                    "id": "P01112",
                    "url": "https://omabrowser.org/oma/group/P01112/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "GTPase activity",
                        "id": "GO:0003924",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GTP binding",
                        "id": "GO:0005525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-membrane adaptor activity",
                        "id": "GO:0043495",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043495",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GDP binding",
                        "id": "GO:0019003",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019003",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "G protein activity",
                        "id": "GO:0003925",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003925",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 47,
                "go_terms": [
                    {
                        "name": "signal transduction",
                        "id": "GO:0007165",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of protein phosphorylation",
                        "id": "GO:0001934",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of transcription by RNA polymerase II",
                        "id": "GO:0006357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endocytosis",
                        "id": "GO:0006897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chemotaxis",
                        "id": "GO:0006935",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell surface receptor signaling pathway",
                        "id": "GO:0007166",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell population proliferation",
                        "id": "GO:0008284",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of cell population proliferation",
                        "id": "GO:0008285",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of gene expression",
                        "id": "GO:0010629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of phospholipase C activity",
                        "id": "GO:0010863",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010863",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of cell migration",
                        "id": "GO:0030335",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of actin cytoskeleton organization",
                        "id": "GO:0032956",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell population proliferation",
                        "id": "GO:0042127",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042127",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of MAPK cascade",
                        "id": "GO:0043410",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of GTPase activity",
                        "id": "GO:0043547",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of transcription by RNA polymerase II",
                        "id": "GO:0045944",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of JNK cascade",
                        "id": "GO:0046330",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of long-term neuronal synaptic plasticity",
                        "id": "GO:0048169",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048169",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuron apoptotic process",
                        "id": "GO:0051402",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051402",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adipose tissue development",
                        "id": "GO:0060612",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060612",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of ERK1 and ERK2 cascade",
                        "id": "GO:0070374",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "MAPK cascade",
                        "id": "GO:0000165",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000165",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "T-helper 1 type immune response",
                        "id": "GO:0042088",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042088",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "myelination",
                        "id": "GO:0042552",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042552",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "T cell receptor signaling pathway",
                        "id": "GO:0050852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of neuron apoptotic process",
                        "id": "GO:0043524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Ras protein signal transduction",
                        "id": "GO:0007265",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of MAP kinase activity",
                        "id": "GO:0043406",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043406",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of wound healing",
                        "id": "GO:0090303",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090303",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "animal organ morphogenesis",
                        "id": "GO:0009887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "insulin receptor signaling pathway",
                        "id": "GO:0008286",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008286",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of type II interferon production",
                        "id": "GO:0032729",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032729",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of GTPase activity",
                        "id": "GO:0034260",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034260",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of fibroblast proliferation",
                        "id": "GO:0048146",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048146",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intrinsic apoptotic signaling pathway",
                        "id": "GO:0097193",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097193",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of protein targeting to membrane",
                        "id": "GO:0090314",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090314",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular senescence",
                        "id": "GO:0090398",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090398",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "fibroblast proliferation",
                        "id": "GO:0048144",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048144",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of epithelial cell proliferation",
                        "id": "GO:0050679",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050679",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to protozoan",
                        "id": "GO:0042832",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to gamma radiation",
                        "id": "GO:0071480",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071480",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Schwann cell development",
                        "id": "GO:0014044",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014044",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane",
                        "id": "GO:0098696",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098696",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cell cycle",
                        "id": "GO:0051726",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of miRNA metabolic process",
                        "id": "GO:2000630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of ruffle assembly",
                        "id": "GO:1900029",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900029",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "oncogene-induced cell senescence",
                        "id": "GO:0090402",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090402",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 11,
                "go_terms": [
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glutamatergic synapse",
                        "id": "GO:0098978",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "perinuclear region of cytoplasm",
                        "id": "GO:0048471",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GTPase complex",
                        "id": "GO:1905360",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905360",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "P01112",
                                "url": "https://www.uniprot.org/uniprot/P01112"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 85,
            "end_pos": 87,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "(Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL (PubMed:8626586, PubMed:8626575, PubMed:9632667, PubMed:19744486). Monoglucosylation completely prevents the recognition of the downstream effector, blocking the GTPases in their inactive form, leading to inhibit Ras signaling (PubMed:8626586, PubMed:8626575, PubMed:9632667).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "8626586",
                    "url": "https://glygen.org/publication/PubMed/8626586"
                },
                {
                    "database": "PubMed",
                    "id": "9632667",
                    "url": "https://glygen.org/publication/PubMed/9632667"
                },
                {
                    "database": "PubMed",
                    "id": "8626575",
                    "url": "https://glygen.org/publication/PubMed/8626575"
                },
                {
                    "database": "PubMed",
                    "id": "19744486",
                    "url": "https://glygen.org/publication/PubMed/19744486"
                }
            ]
        },
        {
            "annotation": "Fatty-acylated at Lys-170.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "29239724",
                    "url": "https://glygen.org/publication/PubMed/29239724"
                }
            ]
        },
        {
            "annotation": "Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "P01112",
                    "url": "https://www.uniprot.org/uniprot/P01112"
                },
                {
                    "database": "PubMed",
                    "id": "30442762",
                    "url": "https://glygen.org/publication/PubMed/30442762"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [
        {
            "id": "19669",
            "name": "",
            "equation": "GTP + H2O = GDP + H(+) + phosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q08877-1",
                "Q6AYC2-1",
                "Q2TA68-1",
                "P61589-1",
                "Q6RUV5-1",
                "P23640-1",
                "O35303-1",
                "P21575-1",
                "P39052-1",
                "Q6AYF9-1",
                "Q8CFN2-1",
                "Q63663-1",
                "M0RC99-1",
                "Q99P74-1",
                "B2GUV7-1",
                "Q8R4Z9-1",
                "Q8R500-1",
                "D3ZQL7-1",
                "P97538-1",
                "Q6IMA3-1",
                "Q5BJQ5-1",
                "Q62636-1",
                "Q63486-1",
                "Q63487-1",
                "P61227-1",
                "P62836-1",
                "P63322-1",
                "Q04970-1",
                "P08644-1",
                "D3Z8L7-1",
                "P35281-1",
                "P36860-1",
                "Q6IMA7-1",
                "C9WPN6-1",
                "P20171-1",
                "P81795-1",
                "Q6AYZ1-1",
                "Q6AY56-1",
                "Q99MB4-1",
                "Q5XIF6-1",
                "P84079-1",
                "P68370-1",
                "Q68FR8-1",
                "Q6P9V9-1",
                "P51146-1",
                "O35509-1",
                "P62494-1",
                "Q6NYB7-1",
                "Q66HA6-1",
                "P09527-1",
                "P10536-1",
                "P05714-1",
                "Q8K586-1",
                "P62828-1",
                "P62332-1",
                "P35280-1",
                "P05712-1",
                "Q6AYB5-1",
                "Q6AXM7-1",
                "P05197-1",
                "P62630-1",
                "D3ZM99-1",
                "D3ZLK2-1",
                "Q5BJP6-1",
                "F1M2G3-1",
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                "Q00246-1",
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                "Q00582-1",
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                "Q55CC0-1",
                "Q75K18-1",
                "Q869Q0-1",
                "Q86L51-1",
                "B0G189-1",
                "O00909-1",
                "P03967-1",
                "P0CT31-1",
                "P15064-1",
                "P15112-1",
                "P18613-1",
                "P32252-1",
                "P32253-1",
                "P32254-1",
                "P32255-1",
                "P36409-1",
                "P36411-1",
                "Q54MH8-1",
                "Q55AX0-1",
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                "P08646-1",
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                "P27619-1",
                "Q7YU24-1",
                "P48555-1",
                "Q9VRH6-1",
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            ],
            "evidence": [
                {
                    "id": "19669",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/19669"
                }
            ]
        },
        {
            "id": "R-HSA-109807",
            "name": "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS",
            "equation": "",
            "summary": "SOS promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity. NGF-induced RAS activation via SHC-GRB2-SOS is maximal at 2 min but it is no longer detected after 5 min. Therefore, the transient activation of RAS obtained through SHC-GRB2-SOS is insufficient for the prolonged activation of ERKs found in NGF-treated cells.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-109807",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-109807"
                }
            ]
        },
        {
            "id": "R-HSA-109817",
            "name": "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS",
            "equation": "",
            "summary": "SOS promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity. NGF-induced RAS activation via SHC-GRB2-SOS is maximal at 2 min but it is no longer detected after 5 min. Therefore, the transient activation of RAS obtained through SHC-GRB2-SOS is insufficient for the prolonged activation of ERKs found in NGF-treated cells.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-109817",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-109817"
                }
            ]
        },
        {
            "id": "R-HSA-1168636",
            "name": "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP",
            "equation": "",
            "summary": "RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) catalyze the exchange of GDP for GTP bound by RAS.",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1168636",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1168636"
                }
            ]
        },
        {
            "id": "R-HSA-1225951",
            "name": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)",
            "equation": "",
            "summary": "Based on the wild-type EGFR signaling, it is assumed that the guanine nucleotide exchange factor SOS1 interacts with phosphorylated EGFR mutants through the adaptor protein, GRB2. Upon formation of this complex, SOS1 activates RAS by promoting GDP release and GTP binding. Although this reaction has not been directly confirmed for EGFR cancer mutants, activation of RAF/MAP kinase cascade has been demonstrated, through detection of phosphorylated ERK1/2, in cells expressing EGFR L858R mutant (Sordella et al. 2004, Paez et al. 2004, Shimamura et al. 2005), EGFR E746_A750del mutant (Sordella et al. 2004, Shimamura et al. 2005), EGFR L747_P753delinsS mutant (Sordella et al. 2004) and EGFR E746_A750del;T790M double mutant (Shimamura et al. 2005).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P07900-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1225951",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1225951"
                }
            ]
        },
        {
            "id": "R-HSA-1225957",
            "name": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)",
            "equation": "",
            "summary": "SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1, recruited by GRB2 bound to p-SHC1:p-EGFR mutants, is assumed to activate RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP). Although this reaction has not been shown to occur directly for EGFR cancer mutants, activation of RAF/MAP kinase cascade, through detection of phosphorylated ERK1/2, has been demonstrated in cells expressing EGFR L858R mutant (Sordella et al. 2004, Paez et al. 2004, Shimamura et al. 2005), EGFR E746_A750 mutant (Sordella et al. 2004, Shimamura et al. 2005), EGFR L747_P753delinS mutant (Sordella et al. 2004), and EGFR E746_A750del;T790M double mutant (Shimamura et al. 2005).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P07900-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1225957",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1225957"
                }
            ]
        },
        {
            "id": "R-HSA-1250383",
            "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4",
            "equation": "",
            "summary": "SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 activates RAS by mediating guanyl nucleotide exchange, which results in the activation of RAF/MAP kinase cascade (Kainulainen et al. 2000).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1250383",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1250383"
                }
            ]
        },
        {
            "id": "R-HSA-1250463",
            "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers",
            "equation": "",
            "summary": "SOS1, bound to GRB2 in complex with phosphorylated SHC1 and phosphorylated ERBB2 dimers, catalyzes guanyl-nucleotide exchange on RAS (Xie et al. 1995).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1250463",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1250463"
                }
            ]
        },
        {
            "id": "R-HSA-1250498",
            "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.",
            "equation": "",
            "summary": "SOS1 bound to GRB2 in complex with phosphorylated ERBB2:EGFR heterodimer catalyzes guanyl-nucleotide exchange on RAS, leading to activation of the MAP kinase cascade (Janes et al. 1994).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1250498",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1250498"
                }
            ]
        },
        {
            "id": "R-HSA-1306972",
            "name": "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers",
            "equation": "",
            "summary": "SOS1 bound to GRB2 in complex with any of the  phosphorylated ERBB2:ERBB4 heterodimers catalyzes guanyl-nucleotide exchange on RAS, leading to the activation of the MAP kinase cascade.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1306972",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1306972"
                }
            ]
        },
        {
            "id": "R-HSA-1433471",
            "name": "Activation of RAS by p-KIT bound SOS1",
            "equation": "",
            "summary": "Once recruited to the membrane in response to c-Kit stimulation, Son of sevenless (SOS1) activates the small GTPase protein RAS. SOS1 is a dual specificity guanine nucleotide exchange factor (GEF) that regulates both Ras and Rho family GTPases. SOS1 activates RAS by binding, which induces a  conformational change that causes the exchange of GDP for GTP. RAS proteins are membrane-bound GTPases that regulate crucial cellular processes such as growth, proliferation and differentiation. Active RAS-GTP stimulates multiple effector proteins such as RAF-1, which induce a variety of cellular responses including initiation of mitogen activated protein kinase (MAPK) cascade signaling.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P10721-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-1433471",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1433471"
                }
            ]
        },
        {
            "id": "R-HSA-170986",
            "name": "Ral-GDS binds to Ras-GTP",
            "equation": "",
            "summary": "Besides the RAF kinase, RAS can activate several ral guanine nucleotide dissociation stimulators (RALGDSs). Binding of RALGDS with RAS competes with RAF binding to RAS.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-170986",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-170986"
                }
            ]
        },
        {
            "id": "R-HSA-171026",
            "name": "Guanine nucleotide exchange on RAL",
            "equation": "",
            "summary": "The Ras-related protein, RAL becomes activated once GDP is replaced by GTP.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P11233-1",
                "P01112-1",
                "P11234-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-171026",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-171026"
                }
            ]
        },
        {
            "id": "R-HSA-177938",
            "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)",
            "equation": "",
            "summary": "The guanine nucleotide exchange factor SOS1 interacts with EGFR through the adaptor protein, GRB2. Upon formation of this complex, SOS activates RAS by promoting GDP release and GTP binding.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-177938",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-177938"
                }
            ]
        },
        {
            "id": "R-HSA-177945",
            "name": "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)",
            "equation": "",
            "summary": "Son of sevenless homolog 1 (SOS1) is the guanine nucleotide exchange factor (GEF) for rat sarcoma (RAS) protein. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-177945",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-177945"
                }
            ]
        },
        {
            "id": "R-HSA-186834",
            "name": "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)",
            "equation": "",
            "summary": "SOS is the guanine nucleotide exchange factor (GEF) for RAS. SOS activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).<br>",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P16234-1",
                "P01112-1",
                "P09619-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-186834",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-186834"
                }
            ]
        },
        {
            "id": "R-HSA-210977",
            "name": "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)",
            "equation": "",
            "summary": "Sos-1 bound to Grb2:Tie2 complex promotes the exchange of inactive Ras-GDP to active Ras-GTP (Boriack-Sjodin et al.1998, Khan et al. 2004).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q02763-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-210977",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-210977"
                }
            ]
        },
        {
            "id": "R-HSA-2179407",
            "name": "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)",
            "equation": "",
            "summary": "SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP) (Chardin et al. 1993).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-2179407",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2179407"
                }
            ]
        },
        {
            "id": "R-HSA-2424477",
            "name": "SOS mediated nucleotide exchange of RAS (SHC)",
            "equation": "",
            "summary": "GRB2-bound SOS promotes the formation of active GTP-bound RAS. This activates the mitogen-activated protein kinase (MAPK) cascade, leading to cell growth and differentiation.",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-2424477",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2424477"
                }
            ]
        },
        {
            "id": "R-HSA-392054",
            "name": "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras",
            "equation": "",
            "summary": "The guanine nucleotide exchange factor SOS interacts with GRB2 bound to phosphorylated FAK bound to NCAM. Upon formation of this complex, SOS activates Ras by promoting GDP release and GTP binding.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P06241-1",
                "P01112-1",
                "P18433-5",
                "Q05397-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-392054",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-392054"
                }
            ]
        },
        {
            "id": "R-HSA-4093331",
            "name": "Ras:GTP binds p120-RasGAP",
            "equation": "",
            "summary": "p120-RasGAP (RASA1) binds to activated Ras (Ras:GTP) through its GAP-related catalytic domain, which is sufficient for stimulating the Ras GTPase activity. p120-RasGAP accelerates the intrinsic GTPase activity of Ras to promote Ras inactivation (Yao et al. 1995).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01112-1",
                "P29323-1",
                "P54760-1",
                "P54753-1",
                "P54762-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-4093331",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4093331"
                }
            ]
        },
        {
            "id": "R-HSA-4093339",
            "name": "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it",
            "equation": "",
            "summary": "The p120-RasGAP C-terminus contains a GAP domain that catalyses the activation of H-Ras by hydrolyzing GTP-bound active Ras into an inactive GDP-bound form of Ras. Inactivation of H-Ras by EPHB2 down regulates MAP kinase phosphorylation and induces neurite retraction in neuronal cells (Elowe et al. 2001, Tong et al. 2003).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01112-1",
                "P29323-1",
                "P54760-1",
                "P54753-1",
                "P54762-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-4093339",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4093339"
                }
            ]
        },
        {
            "id": "R-HSA-442732",
            "name": "NMDA-activated RASGRF1 activates RAS",
            "equation": "",
            "summary": "Binding of RASGRF1 oligomers (Anborgh et al. 1999) to calcium-activated calmodulin (CALM1:4xCa2+) stimulates GDP to GTP exchange on RAS, resulting in RAS activation (Farnsworth et al. 1995). Binding of RASGRF1 to the GluN2B (GRIN2B, NR2B) subunit of NMDA receptors is needed for activation of RAS downstream of NDMA receptor activation (Krapivinsky et al. 2003).<br>Activated CaMKII can contribute to activation of RAS/RAF/MAPK signaling by phosphorylation of RAF1 (Salzano et al. 2012).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q9UQM7-1",
                "Q13554-1",
                "P01112-1",
                "Q13557-1",
                "Q13555-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-442732",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-442732"
                }
            ]
        },
        {
            "id": "R-HSA-5218845",
            "name": "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate",
            "equation": "",
            "summary": "Membrane-bound sphingosine (SPG) in cells attenuates basal Ras activity by stimulating the activity of Ras GTPase-activating proteins (RasGAPs). Upon its phosphorylation by SPHK1, SPG is converted to sphingosine 1-phosphate (S1P) which then displaces from GAP downregulating RASA1 (p120GAP) activity and thereby induces Ras-GTP accumulation. This overall increases the level of activated Ras-GTP leading to activation of the ERK/mitogen-activated protein kinase (MAPK) pathway and cell division (Shu et al. 2002, Wu et al. 2003, Spiegel & Milstien 2006).",
            "cellular_location": "cytosol, endoplasmic reticulum membrane",
            "input_participant_list": [],
            "output_participant_list": [
                "R-HSA-186833"
            ],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "Q9NYA1-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5218845",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5218845"
                }
            ]
        },
        {
            "id": "R-HSA-5621573",
            "name": "CD209 activate GTPase RAS",
            "equation": "",
            "summary": "Both CLEC7A (Dectin-1) and CD209 (DC-SIGN) modulates Toll-like receptor signalling by activating RAF1 which in turn induces the phosphorylation of p65 (RELA) subunit leading to the modification of p50/p65 NF-kB dimer (Gringhuis et al. 2007 & 2009). Gringhuis et al. demonstrated that CD209 (DC-SIGN) stimulated by ManLAM (lipoarabinomannan) activates the small GTPase RAS. Immunoblotting detected active RAS in dendritic cells when induced by ManLAM (Gringhuis et al. 2007). RAF1 is recruited to the membrane through an interaction with the active form of RAS.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5621573",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621573"
                }
            ]
        },
        {
            "id": "R-HSA-5624486",
            "name": "SFKs phosphorylates RAF1 on Y340,Y341",
            "equation": "",
            "summary": "Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P06241-1",
                "P04049-1",
                "P07948-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5624486",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5624486"
                }
            ]
        },
        {
            "id": "R-HSA-5624492",
            "name": "PAK phosphorylates p21 RAF1 on S338",
            "equation": "",
            "summary": "RAF regulation is highly complex and is not solely mediated by conformational changes but also requires phosphorylation. Several phosphorylation sites on RAF1 have been identified that are involved in its kinase activity. Two of these phosphorylation sites are serine 338 (S338) and tyrosine 340 and 341 (Y340/341). Gringhuis et al. demonstrated that ManLAM activation of CD209 (DC-SIGN) results in induced phosphorylation of RAF1 on S338 and Y340/341. The phosphorylation of S338 is mediated by p21-activated kinases (PAK). Inhibition of Rho GTPases with toxin B blocks CD209 induced phosphorylation of RAF1on S338 (Gringhuis et al. 2007, Wellbrock et al. 2004).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "Q13153-1",
                "Q13177-1",
                "P01112-1",
                "O75914-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5624492",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5624492"
                }
            ]
        },
        {
            "id": "R-HSA-5624494",
            "name": "RAF1 binds p21 RAS:GTP",
            "equation": "",
            "summary": "Upon CLEC7A (Dectin-1) and CD209 (DC-SIGN) activation, RAF1 translocates to the membrane through interaction with the active form of RAS. This interaction induces a conformational change in RAF1 and is required for RAF1 activation (Gringhuis et al. 2007, Wellbrock et al. 2004).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5624494",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5624494"
                }
            ]
        },
        {
            "id": "R-HSA-5637806",
            "name": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)",
            "equation": "",
            "summary": "Based on the wild-type EGFR signaling, it is assumed that the guanine nucleotide exchange factor SOS1 interacts with phosphorylated EGFRvIII mutant through the adaptor protein, GRB2. Upon formation of this complex, SOS1 activates RAS by promoting GDP release and GTP binding. Although this reaction has not been directly confirmed for EGFRvIII cancer mutant, RAS-MAPK signaling cascade is activated in cells expressing EGFRvIII (Montgomery et al.1995).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P07900-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5637806",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5637806"
                }
            ]
        },
        {
            "id": "R-HSA-5637808",
            "name": "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)",
            "equation": "",
            "summary": "SOS1 is the guanine nucleotide exchange factor (GEF) for RAS. SOS1, recruited by GRB2 bound to p-SHC1:p-EGFRvIII mutant, is assumed to activate RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP). Although this reaction has not been shown to occur directly for EGFRvIII cancer mutant, activation of RAF/MAP kinase cascade has been demonstrated in cells expressing EGFRvIII (Montgomery et al. 1995).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P07900-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5637808",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5637808"
                }
            ]
        },
        {
            "id": "R-HSA-5654392",
            "name": "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654392",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654392"
                }
            ]
        },
        {
            "id": "R-HSA-5654402",
            "name": "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654402",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654402"
                }
            ]
        },
        {
            "id": "R-HSA-5654413",
            "name": "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654413",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654413"
                }
            ]
        },
        {
            "id": "R-HSA-5654426",
            "name": "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P22455-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654426",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654426"
                }
            ]
        },
        {
            "id": "R-HSA-5654600",
            "name": "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654600",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654600"
                }
            ]
        },
        {
            "id": "R-HSA-5654618",
            "name": "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654618",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654618"
                }
            ]
        },
        {
            "id": "R-HSA-5654647",
            "name": "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654647",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654647"
                }
            ]
        },
        {
            "id": "R-HSA-5654663",
            "name": "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "SOS, recruited by GRB2:p-FRS2 to activated FGFR, activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state.",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P22455-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5654663",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654663"
                }
            ]
        },
        {
            "id": "R-HSA-5655241",
            "name": "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P21802-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5655241",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655241"
                }
            ]
        },
        {
            "id": "R-HSA-5655277",
            "name": "Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P22607-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5655277",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655277"
                }
            ]
        },
        {
            "id": "R-HSA-5655326",
            "name": "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P11362-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5655326",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655326"
                }
            ]
        },
        {
            "id": "R-HSA-5655347",
            "name": "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "Activation of Erk1/2 downstream of FGFR mutants suggests that, as is the case for WT FGFR, FGFR mutant-associated SOS1 activates RAS nucleotide exchange from the inactive GDP-bound to the active GTP-bound state (see for instance, Weiss, 2010; Dutt, 2011; Raffioni, 1998; Cha, 2009; Hart, 2000; Turner, 2010; Kunii, 2008; Byron, 2008; Roidl, 2010; Chesi, 2001; Ronchetti, 2001; reviewed in Wesche, 2011).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P22455-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5655347",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655347"
                }
            ]
        },
        {
            "id": "R-HSA-5658231",
            "name": "RAS GAPs stimulate RAS GTPase activity",
            "equation": "",
            "summary": "The intrinsic GTPase activity of RAS proteins is stimulated by the GAP proteins, of which there are at least 10 in the human genome (reviewed in King et al, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5658231",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5658231"
                }
            ]
        },
        {
            "id": "R-HSA-5658435",
            "name": "RAS GAPs bind RAS:GTP",
            "equation": "",
            "summary": "The human genome encodes at least 10 proteins that bind RAS and activate its intrinsic GTPase activity, resulting in the formation of inactive RAS:GDP and attenuating RAS signaling (reviewed in King et al, 2013). These identified RAS GAP proteins are RASA1 (also known as p120 GAP), NF1, the GAP1 family (RASA2, RASA3, RASA4 and RASAL1) and the SYNGAP family (SYNGAP1, DAB2IP, RASAL2 and RASAL3). GAP proteins stimulate RAS GTPase activity by inserting a conserved arginine residue into the RAS active site, promoting a conformational change in the active site to allow GTP hydrolysis (Ahamdian et al, 2003; Scheffzek et al, 1997; Ahamdian et al, 1997). In addition to the GAP domain, most RAS GAP proteins also contain membrane targeting domains that facilitate interaction with the plasma membrane where RAS is tethered.  In some cases, such as RASA3, membrane localization is constitutive, whereas in others, the GAP proteins are targeted to the membrane in response to cellular signaling.  In addition to binding RAS, a number of GAP proteins also mediate other protein-protein interactions and act as scaffolds to integrate signaling; some GAPs are also known to bind and activate other small GTPases such as RAP (reviewed in King et al, 2013).  Loss-of-functions mutations in RAS GAP proteins have been identified in a number of cancers (reviewed in Maertens and Cichowski, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5658435",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5658435"
                }
            ]
        },
        {
            "id": "R-HSA-5672950",
            "name": "Activator\" RAF:YWHAB dimer binds RAS:GTP\"",
            "equation": "",
            "summary": "Activation of RAS downstream of extracellular signals allows RAS:GTP to recruit BRAF to the plasma membrane, disrupting the pre-existing inactivating interaction between BRAF and the 14-3-3 protein YWHAB (Marais et al, 1997; Yamamori et al, 1995; reviewed in Cseh et al, 2014). BRAF, unique of the three mammalian RAF proteins, is constitutively phosphorylated on the conserved serine residue (446 in BRAF) in the N-terminal acidic motif (NtA). Constitutive negative charge in this region is critical for BRAF to function as an activator of other RAF molecules, allowing signal amplification (Marais et al, 1997; Mason et al, 1999; Wan et al, 2004; Garnett et al, 2005; Hu et al, 2013; reviewed in Cseh et al, 2014). RAS:GTP-bound BRAF heterodimerizes with additional RAF monomers, allowing  cis-autophosphorylation in the activation loop of the second RAF protein. Once activated by BRAF in this manner, the 'receiver' kinase monomer is competent to dimerize with and transactivate other monomers in turn (Weber et al, 2001; Garnett et al, 2005; Hu et al, 2013; reviewed in Cseh et al, 2014). Intruigingly, the scaffold protein KSR1 is activated by BRAF in a manner analogous to other RAF monomers and can similarly act as a RAF activator once it is itself activated (Brennan et al, 2011;  Ory et al, 2003; reviewed in Raabe and Rapp, 2003; Cseh et al, 2014).<br><br>Although this pathway shows PP2A-mediated dephosphorylation of RAF and transient displacement of 14-3-3 proteins as preceding RAS and plasma membrane binding of RAF proteins, the order and dependency of these events is not clear. Both membrane binding and 14-3-3 displacement also appear to be facilitated by an interaction between RAF and the cell cycle protein Prohibitin (PHB; Rajalingam et al, 2005; reviewed in Rajalingam and Rudel, 2005; Chowdhury et al, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P01112-1",
                "Q8IVT5-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672950",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672950"
                }
            ]
        },
        {
            "id": "R-HSA-5672965",
            "name": "RAS GEFs promote RAS nucleotide exchange",
            "equation": "",
            "summary": "The human genome is predicted to encode 27 RAS guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP on membrane-associated RAS in response to RAS-MAPK pathway activation by growth factors, hormones, cytokines and other stimuli (reviewed in Cherfils and Zeghouf, 2013; Cargnello and Roux, 2011).  Nucleotide exchange stimulates a conformational change in RAS to facilitate its interaction with RAF, ultimately promoting the phosphorylation of downstream effectors MAPK3 and MAPK1 (also known as ERK1 and ERK2) (reviewed in Cseh et al, 2014; Vigil et al, 2010).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P07949-1",
                "P22455-1",
                "P52333-1",
                "P16234-1",
                "O60674-1",
                "Q9UQM7-1",
                "P00533-1",
                "P04626-1",
                "P06241-1",
                "P10721-1",
                "Q13554-1",
                "Q02763-1",
                "P01112-1",
                "P36888-1",
                "P09619-1",
                "P18433-5",
                "Q05397-1",
                "Q13557-1",
                "P08581-1",
                "P23458-1",
                "Q13555-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672965",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672965"
                }
            ]
        },
        {
            "id": "R-HSA-5672966",
            "name": "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers",
            "equation": "",
            "summary": "RAF activation depends on the formation of a side-by-side asymmetric homo- or heterodimer (formed from either 2 RAF monomers or a RAF monomer and KSR1) (Weber et al, 2001; Garnett et al, 2005; Rushworth et al, 2006; Rajakulendran et al, 2009; Hu et al, 2013). Dimerization is mediated by cluster of basic residues in the kinase domain, and mutation of these critical residues abrogates RAF activation (Rajakulendran et al, 2009). Dimerization is required for the 'activator' monomer to induce an allosteric change in the 'receiver' monomer that, in conjunction with activation loop phosphorylation, activates the kinase activity of the receiver (Hu et al, 2013). BRAF, by virtue of its constitutive negative charge in the NtA region, is uniquely able to function as an activator RAF without further modification, while RAF1, ARAF and KSR1 can function as activators only after being phosphorylated in the NtA region downstream of RAF pathway activation (Hu et al, 2013; Leicht et al, 2013; reviewed in Cseh et al, 2014). Homo and heterodimerization of RAF monomers may be promoted by association with MAP3K11, which interacts with BRAF and RAF1 in vitro and in vivo and which is required for RAF activation (Chadee et al, 2004a, Chadee et al, 2004b; Chadee et al, 2006).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "Q7Z569-1",
                "P01112-1",
                "Q8IVT5-1",
                "Q16584-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672966",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672966"
                }
            ]
        },
        {
            "id": "R-HSA-5672969",
            "name": "Phosphorylation of RAF",
            "equation": "",
            "summary": "Downstream of RAF dimerization and allosteric activation, RAF monomers and KSR1 undergo a series of activating phosphorylations in both the activation loop (AL) and, in the case of ARAF, RAF1 and KSR1, in the NtA . Phosphorylation of the activation loop residues (T491, S494 in RAF1, T452, T455 in ARAF and T599, S602 in BRAF) contributes to full kinase activity, although this may be less critical for ARAF, and RAFs in general, than for other kinases due to their regulation by 14-3-3 binding (Zhu et al, 2005; Zhang et al, 2000; Baljuls et al, 2008, reviewed in Matallanas et al, 2011; Udell et al, 2011). AL phosphorylation may occur through cis-autophosphorylation within the RAF dimer, although phosphorylation by other kinases is also possible (Hu et al, 2013; reviewed in Matallanas et al, 2011). <br><br>Phosphorylation in the RAF NtA region is required for full kinase activity, for interaction with MAP2K substrates and for the ability of activated RAF to act as an allosteric activator of other RAF monomers (Marais et al, 1995; Diaz et al, 1997; Xiang et al, 2002; Edin et al, 2005; Hu et al, 2013; Mason et al, 1999).  Phosphorylation of these residues (S338 and Y441 in RAF1, S299 and Y302 in ARAF and Y602 in KSR1) may be mediated by a kinase of the SRC, JAK or PAK family kinases, by MAP2K kinases, calmodulin kinase CaMKII or through autophosphorylation by RAF itself (Marais et al, 1995; Xia et al, 1996; King et al, 1998; Sun et al, 2000; Tran et al, 2003; Tran et al, 2005; Salzano et al. 2012, Hu et al, 2013; reviewed in Matallanas et al, 2011). The phosphorylated NtA of RAF1 is also the binding site for the negative regulator PEPB1, also known as RKIP.  PEBP1 binding to RAF1 prevents phosphorylation of the MAP2K substrates (Park et al, 2006; Rath et al, 2008; reviewed in Shin et al, 2009).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O60674-1",
                "Q9UQM7-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "Q13554-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q13557-1",
                "Q13555-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672969",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672969"
                }
            ]
        },
        {
            "id": "R-HSA-5672972",
            "name": "MAP2Ks and MAPKs bind to the activated RAF complex",
            "equation": "",
            "summary": "RAF kinases have restricted substrate specificity and have as their primary substrates the two MAP2K proteins MAP2K1 and MAP2K2 (also known as MEK1 and 2). MAP2K1 knockout is embryonic lethal in mice, while MAP2K2 knockouts have no apparent abnormalities, suggesting that MAP2K1 can compensate for MAP2K2 in vivo (Giroux et al, 1999; Belanger et al, 2003). MAP2K proteins exist as stable homo- and heterodimers independent of growth factor stimulation and are generally recruited to activated RAF proteins in conjunction with a scaffolding protein and the MAP2K substrates, MAPK1 and 3 (also known as ERK1 and 2) (Ohren et al, 2004; Catalanotti et al, 2009; Catling et al, 1995; reviewed in Matallanas et al, 2011; Roskoski et al, 2012a; Roskoski et al, 2012b). <br><br>Scaffolding proteins promote signaling by providing a docking platform that colocalizes components of the signaling cascade, and provide specificity by controlling the spatial and temporal regulation of the pathway (reviewed in Brown and Sacks, 2009; Matallanas et al, 2011).  KSR1 and 2, CNKSR1 and 2, IQGAP1 and the beta arrestins are among the known MAPK scaffold proteins that act at the plasma membrane upon MAPK pathway activation; in addition, paxillin localizes MAPK pathway components to focal adhesion sites in the plasma membrane (Roy et al, 2005; Ren et al, 2007; DeFea et al, 2000; Togho et al, 2003; Ishibe et al, 2003; reviewed in Claperon and Therrien, 2007; Brown and Sacks, 2009; Matallanas et al, 2011). Although this reaction depicts these scaffolding proteins acting equivalently, the details of how they promote pathway activation vary.  For instance, KSR1 and 2 are constitutively bound to MAP2K dimers but recruit MAPKs only upon pathway stimulation, while IQGAP1 associates constitutively with both MAP2K and MAPK proteins in unstimulated cells and shows increased interaction with MAP2K1 upon pathway activation by EGF (Stewart et al, 1999; Cacace et al, 2000; Muller et al, 2000; Roy et al, 2004; Roy et al, 2005; reviewed in Brown and Sacks, 2009). Scaffolding complexes may be particularly important for the phosphorylation of cytosolic MAPK targets (reviewed in Casar et al, 2009).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672972",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672972"
                }
            ]
        },
        {
            "id": "R-HSA-5672973",
            "name": "MAP2Ks phosphorylate MAPKs",
            "equation": "",
            "summary": "Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672973",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672973"
                }
            ]
        },
        {
            "id": "R-HSA-5672978",
            "name": "RAF phosphorylates MAP2K dimer",
            "equation": "",
            "summary": "Activated RAF phosphorylates the MEK kinases MAP2K1 and MAP2K2 on 2 serine residues in the MAP2K activation loop (S218 and S222 in MAP2K1 and S222 and S226 in MAP2K2 (Zheng and Guan, 1994; Alessi et al, 1994; Catling et al, 1995; Papin et al, 1995; Seger et al, 1994; reviewed in Roskoski, 2012a).  Although all three RAF kinases can phosphorylate MAP2K1 and MAP2K2, BRAF appears to be the primary activator in vivo (Marais et al, 1997; Jaiswal et al, 1994; Pritchard et al, 1995; reviewed in Welbrock et al, 2004)",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672978",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672978"
                }
            ]
        },
        {
            "id": "R-HSA-5672980",
            "name": "Dissociation of RAS:RAF complex",
            "equation": "",
            "summary": "The mechanisms governing the dissociation or trafficking of activated MAPK signaling complexes at the plasma membrane are not fully worked out. Some active complexes may be endocytosed and targeted to other cellular locations, for example the Golgi complex (Lorentzen et al, 2010). Activated RAF monomers may dissociate and homo- or heterodimerize with additional inactive RAF monomers and in this way amplify the signal (reviewed in Matallanas et al, 2011; Cseh et al, 2014).<br>Ultimately, active RAF complexes are subject to PP5- and PP2A-mediated dephosphorylation, which promotes a return to the inactive state. Hydrolysis of RAS-bound GTP by the intrinsic GTPase activity, stimulated by association with RAS GAP proteins, ultimately promotes dissociation of RAS from RAF allowing a return to the quiescent state (reviewed in Wellbrock et al, 2004; Matallanas et al, 2011).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5672980",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5672980"
                }
            ]
        },
        {
            "id": "R-HSA-5674018",
            "name": "BRAP binds RAS:GTP",
            "equation": "",
            "summary": "BRAP is a negative regulator of the RAF/MAPK cascade that inhibits the homo- and heterodimerization of KSR1 and RAF and preventing downstream signal propagation (Matheny et al, 2004; Chen et al, 2008; reviewed in Matheny et al, 2009). Upon RAS stimulation, BRAP binds to RAS:GTP.  This stimulates BRAP's E3 HECT ubiquitin ligase activity, promoting its autoubiquitination and thereby relieving the inhibition of KSR1 activity (Matheny et al, 2004; reviewed in Matheny et al, 2009). USP15 is a deubiquitinase that stabilizes BRAP protein levels and thus acts to dampen MAPK signaling (Hayes et al, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q7Z569-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5674018",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674018"
                }
            ]
        },
        {
            "id": "R-HSA-5674022",
            "name": "BRAP autoubiquitinates",
            "equation": "",
            "summary": "Binding to activated RAS stimulates the ubiquitinase activity of BRAP, promoting autoubiquitination and relieving the inhibition of KSR1 (Methany et al, 2004; Chen et al, 2008; Methany et al, 2009).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q7Z569-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5674022",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5674022"
                }
            ]
        },
        {
            "id": "R-HSA-5675417",
            "name": "PEBP1 binds activated RAF1",
            "equation": "",
            "summary": "PEBP1, also known as RKIP (Raf kinase inhibitor protein), is a negative regulator of RAF1 that binds to the phosphorylated NtA region and prevents activation of MAP2K substrates (Yeung et al, 1999; Yeung et al, 2000; Rath et al, 2008; Park et al, 2006; reviewed in Lorenz et al, 2014).  Relief of this PEBP1 repression of RAF1 activity is stimulated by phosphorylation of PEBP1, which promotes it dissociation from RAF1.  Candidate kinases for phosphorylation of PEBP1 include PKC and the MAPKs themselves, which would establish a positive feedback loop stimulating MAPK pathway activity (Corbit et al, 2003; Cho et al, 2003; Shin et al, 2009).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P01112-1",
                "Q8IVT5-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5675417",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675417"
                }
            ]
        },
        {
            "id": "R-HSA-5675431",
            "name": "PP2A dephosphorylates RAF1",
            "equation": "",
            "summary": "Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues.  PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P67775-1",
                "P01112-1",
                "Q8IVT5-1",
                "P62714-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5675431",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675431"
                }
            ]
        },
        {
            "id": "R-HSA-5675433",
            "name": "PP5 dephosphorylates RAF1 S338",
            "equation": "",
            "summary": "PPP5C dephosphorylates S338 in the NtA region of RAF1, which reduces the catalytic activity of RAF1 towards MAP2K proteins (von Kriegsheim et al, 2006; reviewed in Matallanas et al, 2011).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P53041-1",
                "P01112-1",
                "Q8IVT5-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5675433",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5675433"
                }
            ]
        },
        {
            "id": "R-HSA-5686071",
            "name": "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS",
            "equation": "",
            "summary": "SOS1 promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity. NGF-induced RAS activation via SHC-GRB2-SOS is maximal at 2 min but it is no longer detected after 5 min. Therefore, the transient activation of RAS obtained through SHC-GRB2-SOS is insufficient for the prolonged activation of ERKs found in NGF-treated cells.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5686071",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686071"
                }
            ]
        },
        {
            "id": "R-HSA-5686318",
            "name": "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS",
            "equation": "",
            "summary": "SOS promotes the formation of GTP-bound RAS, thus activating this protein. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK), and the catalytic subunit of PI3K, as well as of a series of RALGEFs. The activation cycle of RAS GTPases is regulated by their interaction with specific guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). GEFs promote activation by inducing the release of GDP, whereas GAPs inactivate RAS-like proteins by stimulating their intrinsic GTPase activity.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-5686318",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5686318"
                }
            ]
        },
        {
            "id": "R-HSA-6802834",
            "name": "RAS GTPase mutants don't hydrolyze GTP",
            "equation": "",
            "summary": "RAS is mutated in 25-30% of human cancers, with the majority of tumors carrying mutations at G12, G13 or Q61. Mutation at these sites interferes with the intrinsic and GAP-mediated hydrolysis of GTP, allowing the GTP bound form to persist and promote constitutive signaling (reviewed in Prior et al, 2012; Pylayeva and Gupta, 2011, King et al, 2013; Cox and Der, 2010). RAS GAP proteins interact with RAS by inserting an arginine finger into the RAS active site to promote positioning of the catalytic Q61 residue, stimulating the low intrinsic GTPase activity by several orders of magnitude (Ahmadian et al, 2003; Ahmadian et al, 1997; reviewed in Bos et al, 2007). Mutation of the catalytic Q61 disrupts coordination of a water molecule that is required for nucleophilic attack on the gamma phosphate of GTP, while G12 and G13 mutations abrogate interactions with RAS GAP proteins that are required for proper positioning of the Q61 residue (Trahey et al, 1987; Scheidig et al, 1999; Buhrman et al, 2010; Scheffzek et al,1997). <br>In addition to somatic mutations in cancer, RAS is also subject to germline mutations that lead to a group of developmental disorders collectively known as RASopathies (reviewed in Rauen, 2013; Tidyman and Rauen, 2009). Like their oncogenic counterparts, these RAS mutants show defective GTP hydrolysis and constitutive signaling (Schubbert et al, 2006; Schubbert et al, 2007).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802834",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802834"
                }
            ]
        },
        {
            "id": "R-HSA-6802837",
            "name": "Loss-of-function NF1 variants don't stimulate RAS GTPase activity",
            "equation": "",
            "summary": "NF1 is a RAS GTPase activating protein (GAP) that promotes the conversion of the active RAS:GTP to the inactive RAS:GDP form (reviewed in King et al, 2013).  Germline loss-of-function mutations in NF1 are associated with neurofibromatosis 1, an autosomal dominant disorder that causes aberrant activation of the RAS signaling pathway (reviewed in Tidyman and Rauen, 2009).  More recently, somatic loss-of-function mutations in NF1 have been identified in a number of cancers such as glioblastoma, lung adenocarcinoma, breast and ovarian cancers, leukemia and neuroblastoma, making NF1 a tumor suppressor (Cancer Genome Atlas Research Network, 2008; Parsons et al, 2008; McGillicuddy et al, 2009; Ding et al, 2008; The et al, 1993; Holzel et al, 2010; Maertens et al, 2013; Whittaker et al, 2013; reviewed in Maertens and Cichowski, 2014).  Cancer-associated lesions in the NF1 gene range from homozygous deletions of the entire gene to missense or frameshift mutations that truncate and destabilize the protein; these variant alleles are often expressed at very low levels or not at all and where examined, most cells appear to have compromised GAP activities (Basu et al, 1992; De CLue et al, 1992; Bollag et al, 1996; Klose et al, 1998; Updahyaya et al, 1997; Krauthammer et al, 2015; Nissan et al, 2014; Thomas et al, 2012; reviewed in Maertens and Cichowski, 2014).",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802837",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802837"
                }
            ]
        },
        {
            "id": "R-HSA-6802908",
            "name": "RAS mutants bind inactive RAF",
            "equation": "",
            "summary": "Downstream of oncogenic RAS, a number of pathways are activated in a cancer- and tissue-specific manner. Common effectors include the PI3K/AKT pathway, the RAL GDS pathway and the canonical RAF/MEK/ERK pathway (reviewed in Prior et al, 2012; Pylayeva-Gupta et al, 2011; Stephen et al, 2014). Activation of the RAF/MEK/ERK pathway depends on the recruitment and activation of RAF downstream of oncogenic RAS, although the extent of pathway activation and the importance of the different RAF genes varies among cancer types. For instance, RAF1 (also known as CRAF) is necessary for onset of RAS-driven non-small cell lung cancer and melanoma, but is dispensable in RAS-driven pancreatic ductal adenocarcinoma (Dumaz et al, 2006; Heidorn et al, 2010; Blasco et al, 2011; Karreth et al, 2011; Eser et al, 2013). And although BRAF activity is not required in RAS-driven melanoma as assessed by siRNA knockdown, in the presence of BRAF inhibitors, BRAF paradoxically contributes to pathway activation through dimerization-dependent activation of RAF1 (Dumaz et al, 2006; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Dumaz, 2011; Lito et al, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P15056-1",
                "P01112-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802908",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802908"
                }
            ]
        },
        {
            "id": "R-HSA-6802912",
            "name": "High kinase activity BRAF mutants bind MAP2Ks and MAPKs",
            "equation": "",
            "summary": "High-kinase activity BRAF mutants such as the prevalent V600E mutant bind MAP2K and MAPK proteins to activate signaling in a constitutive, RAS-independent manner (Wan et al, 2004; Garnett et al, 2005; Ritt et al, 2010; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015). These highly active BRAF mutations are thought to disrupt interactions between the DFG motif and the P loop that are required to hold RAF in the inactive, \\DFG out\\ conformation.  In this way, BRAF V600E and other highly active BRAF mutations render the protein constitutively active (Wan et al, 2004; reviewed in Lito et al, 2013; Lavoie and Therrien, 2015).  Although highly active BRAF mutants can heterodimerize with and signal through RAF1, V600E BRAF is resistant to disruptions in the dimerization interface, has relaxed requirements for RAF1 activation loop phosphorylation, and is able to signal as a monomer (Garnett et al, 2005; Ritt et al, 2010; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015; Lito et al, 2013).",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802912",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802912"
                }
            ]
        },
        {
            "id": "R-HSA-6802914",
            "name": "RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs",
            "equation": "",
            "summary": "RAF dimerization and phosphorylation downstream of moderately activating BRAF mutations is associated with increased MAP2K and MAPK phosphorylation (Wan et al, 2004; Freeman et al, 2013; Roring et al, 2012; reviewed in Holderfield et al, 2014; Lavoie and Therrien, 2015).  Although the interactions between oncogenic RAS or RAFs and downstream effectors hasn't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802914",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802914"
                }
            ]
        },
        {
            "id": "R-HSA-6802915",
            "name": "Moderate kinase activity BRAF mutants bind RAS:GTP",
            "equation": "",
            "summary": "In addition to the prevalent and highly activating V600E mutation, a large number of rare, moderately activating BRAF mutations are also found in human cancers (Wan et al, 2004; Davies et al, 2002).  Unlike the V600E mutant, these forms of BRAF require both RAS binding and dimerization to activate MAPK/ERK signaling (Wan et al, 2004; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P15056-1",
                "P01112-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802915",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802915"
                }
            ]
        },
        {
            "id": "R-HSA-6802916",
            "name": "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants",
            "equation": "",
            "summary": "Homo- or heterodimerization (with RAF1, also known as CRAF) downstream of moderate kinase activity BRAF mutants leads to phosphorylation and activation of the 'receiver' kinase.  Unlike the case for the highly active V600E BRAF mutation, pathway activation downstream of moderately activated BRAF mutants depends both on RAS binding and on dimerization (Wan et al, 2004; Roring et al, 2012; Freeman et al, 2013; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015)<br><br>",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O60674-1",
                "Q9UQM7-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "Q13554-1",
                "P01112-1",
                "P36507-1",
                "Q02750-1",
                "Q13557-1",
                "Q13555-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802916",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802916"
                }
            ]
        },
        {
            "id": "R-HSA-6802918",
            "name": "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants",
            "equation": "",
            "summary": "Downstream of kinase-dead or inhibited forms of BRAF, activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassilliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802918",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802918"
                }
            ]
        },
        {
            "id": "R-HSA-6802919",
            "name": "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks",
            "equation": "",
            "summary": "Recruitment of MAP2Ks and MAPKs downstream of moderately activated BRAF mutants leads to phosphorylation and activation of MAP2Ks, as in the WT pathway (Wan et al, 2004; Freeman et al, 2013; Roring et al, 2012; reviewed in Lavoie and Therrien, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802919",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802919"
                }
            ]
        },
        {
            "id": "R-HSA-6802921",
            "name": "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants",
            "equation": "",
            "summary": "MAPKs are phosphorylated downstream of moderately activated BRAF mutants in a MAP2K-dependent manner (Wan et al, 2004; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802921",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802921"
                }
            ]
        },
        {
            "id": "R-HSA-6802922",
            "name": "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS",
            "equation": "",
            "summary": "MAPK proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802922",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802922"
                }
            ]
        },
        {
            "id": "R-HSA-6802924",
            "name": "RAF is phosphorylated downstream of oncogenic RAS",
            "equation": "",
            "summary": "In many cancer types, RAF1 (also known as CRAF) appears to be a critical initial effector of the ERK pathway downstream of activated RAS and also mediates pathway activation in the presence of WT BRAF plus BRAF inhibitors (Rushworth et al, 2006; Dumaz et al, 2006; Garnett et al, 2005; Karreth et al, 2011; Poulikakos et al, 2010; Heidorn et al, 2010; Roring et al, 2012; reviewed in Samatar et al, 2014; Lito et al, 2013). This activation depends largely on heterodimerization with BRAF, although homodimers also contribute (Weber et al, 2001; Rushworth et al, 2006). Activation of RAF downstream of mutant RAS appears to require full phosphorylation of the N-region and the activation loop, unlike the case in BRAF mutant cells, where RAF N-loop phosphorylation is dispensable (Garnett et al, 2005).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O60674-1",
                "Q9UQM7-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "Q13554-1",
                "P01112-1",
                "P36507-1",
                "Q02750-1",
                "Q13557-1",
                "Q13555-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802924",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802924"
                }
            ]
        },
        {
            "id": "R-HSA-6802925",
            "name": "Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs",
            "equation": "",
            "summary": "RAF dimerization and phosphorylation downstream of oncogenic RAS and RAF mutations is associated with increased MAP2K and MAPK phosphorylation (Wan et al, 2004; Garnett et al, 2005; reviewed in Holderfield et al, 2014). Although the interactions between oncogenic RAS or RAFs and downstream effectors hasn't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802925",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802925"
                }
            ]
        },
        {
            "id": "R-HSA-6802926",
            "name": "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks",
            "equation": "",
            "summary": "MAP2K proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802926",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802926"
                }
            ]
        },
        {
            "id": "R-HSA-6802934",
            "name": "p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs",
            "equation": "",
            "summary": "BRAF and RAF fusion proteins expressed in cancer constitutively activate downstream signaling and promote cellular transformation (Jones et al, 2008; Cin et al, 2011; Palanisamy et al, 2010; Ciampi et al, 2005; Stransky et al, 2014; Hutchinson et al, 2013; Zhang et al, 2013; Lee et al, 2012; Ricarte-Filho et al, 2013; reviewed in Lavoie and Therrien et al, 2015).  Recruitment of MAP2Ks and MAPKs to the fusion dimers may occur in conjunction with scaffold proteins as is the case for WT RAF dimers, however this has not been studied in detail.",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "O15164-1",
                "Q6ZMT4-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "Q53H12-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q7KZF4-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "Q5XG87-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802934",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802934"
                }
            ]
        },
        {
            "id": "R-HSA-6802937",
            "name": "Inactive BRAF mutants bind mutant RAS:GTP",
            "equation": "",
            "summary": "The paradoxical activation of ERK signaling downstream of kinase-dead or inhibited forms of BRAF appears to result from enhanced dimerization with RAF1/CRAF (Wan et al, 2004; Poulikakos et al, 2010; Heidorn et al, 2010; Hatzivassilliou et al, 2010; Freeman et al, 2013).  The propensity to dimerize may be promoted by conformational changes in the BRAF monomer as a result of mutation or inhibitor binding (reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).<br>",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P15056-1",
                "P01112-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802937",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802937"
                }
            ]
        },
        {
            "id": "R-HSA-6802941",
            "name": "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF",
            "equation": "",
            "summary": "The enhanced dimerization of inhibited or kinase dead versions of BRAF to RAF1/CRAF stimulates the phosphorylation and transactivation of RAF1 (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).  Other evidence suggests that paradoxical activation of RAF1 by inhibited or inactive BRAF may result from relief of an inhibitory CRAF autophosphorylation event (Holderfield et al, 2013; reviewed in Holderfield, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O60674-1",
                "Q9UQM7-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "Q13554-1",
                "P01112-1",
                "P36507-1",
                "Q02750-1",
                "Q13557-1",
                "Q13555-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802941",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802941"
                }
            ]
        },
        {
            "id": "R-HSA-6802942",
            "name": "RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs",
            "equation": "",
            "summary": "Dimerization of kinase-dead or inhibited versions of BRAF to RAF1/CRAF leads to the recruitment and phosphorylation of MAP2Ks and MAPKs (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010;  Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015). Although the interactions haven't been studied in detail, these disease pathways are presumed to recruit MAP2Ks and MAPKs in a scaffold-dependent manner similar to WT (reviewed in Matallanas et al, 2011).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802942",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802942"
                }
            ]
        },
        {
            "id": "R-HSA-6802943",
            "name": "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks",
            "equation": "",
            "summary": "As in the WT pathway, activation of ERK signaling downstream of kinase-dead or inhibited forms of BRAF depends on phosphorylation of two serine residues in the activation loop of the MAP2K proteins (Wan et al, 2004; Garnett et al, 2005; Heidorn et al, 2010;  Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6802943",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6802943"
                }
            ]
        },
        {
            "id": "R-HSA-6803230",
            "name": "Dissociation of moderate activity BRAF complexes",
            "equation": "",
            "summary": "After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by moderately active BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6803230",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803230"
                }
            ]
        },
        {
            "id": "R-HSA-6803233",
            "name": "Dissociation of oncogenic RAS:RAF complex",
            "equation": "",
            "summary": "After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by oncogenic RAS presumably dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015; Stephen et al, 2014).",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6803233",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803233"
                }
            ]
        },
        {
            "id": "R-HSA-6803234",
            "name": "Dissociation of paradoxically activated RAS:BRAF complexes",
            "equation": "",
            "summary": "After phosphorylation by MAP2Ks, the scaffolded kinase complex assembled by kinase dead or inhibited BRAF mutants dissociates, as is the case for WT complexes (reviewed in Lavoie and Therrien et al, 2015).",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6803234",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803234"
                }
            ]
        },
        {
            "id": "R-HSA-6803240",
            "name": "Homo- or heterodimerization of RAF downstream of mutant RAS",
            "equation": "",
            "summary": "Similar to the WT pathway, activation of RAF downstream of oncogenic RAS depends on homo- or heterodimerization of RAF, although the importance of RAF proteins varies among cancer types (Dumaz et al, 2006; Heidorn et al, 2010; Blasco et al, 2011; Karreth et al, 2011; Eser et al, 2013; Heidorn et al, 2010; Poulikakos et al, 2010; Hatzivassiliou et al, 2010; reviewed in Lito et al, 2013). A notable exception to this requirement for RAF dimerization is BRAF V600E, which is RAS-independent and constitutively active as a monomer (Roring et al, 2012; Brummer et al, 2006; Freeman et al, 2013; Garnett et al, 2005).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "Q7Z569-1",
                "P01112-1",
                "Q8IVT5-1",
                "Q16584-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-6803240",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803240"
                }
            ]
        },
        {
            "id": "R-HSA-8851827",
            "name": "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1",
            "equation": "",
            "summary": "GRB2-1 is an adaptor protein for the RAS guanyl nucleotide exchange factor SOS1. GRB2-1, through association with activated receptor tyrosine kinases, such as MET, mediates recruitment of SOS1 to the plasma membrane. At the plasma membrane, SOS1 catalyzes guanyl nucleotide exchange on RAS proteins from GDP to GTP, resulting in RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P08581-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8851827",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8851827"
                }
            ]
        },
        {
            "id": "R-HSA-8851877",
            "name": "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET",
            "equation": "",
            "summary": "RAS guanyl nucleotide exchange factor SOS1 recruited to MET receptor through association with RANBP9 catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Wang et al. 2002).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P08581-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8851877",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8851877"
                }
            ]
        },
        {
            "id": "R-HSA-8851899",
            "name": "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET",
            "equation": "",
            "summary": "SOS1, recruited to activated MET receptor via interaction of GRB2 with phosphorylated SHC1-2, catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Pelicci et al. 1995).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P08581-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8851899",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8851899"
                }
            ]
        },
        {
            "id": "R-HSA-8936676",
            "name": "Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize",
            "equation": "",
            "summary": "In addition to the prevalent and highly activating V600E mutation, a large number of rare, moderately activating BRAF mutations are also found in human cancers (Wan et al, 2004; Davies et al, 2002).  Unlike the V600E mutant, these forms of BRAF require both RAS binding and dimerization to activate MAPK/ERK signaling (Wan et al, 2004; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "Q7Z569-1",
                "P01112-1",
                "Q8IVT5-1",
                "Q16584-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8936676",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8936676"
                }
            ]
        },
        {
            "id": "R-HSA-8936731",
            "name": "Inactive BRAF mutants:mutant RAS:GTP bind RAF1",
            "equation": "",
            "summary": "The paradoxical activation of ERK signaling downstream of kinase-dead or inhibited forms of BRAF appears to result from enhanced dimerization with RAF1/CRAF (Wan et al, 2004; Poulikakos et al, 2010; Heidorn et al, 2010; Hatzivassilliou et al, 2010; Freeman et al, 2013).  The propensity to dimerize may be promoted by conformational changes in the BRAF monomer as a result of mutation or inhibitor binding (reviewed in Samatar and Poulikakos, 2014; Lavoie and Therrien, 2015).<br>",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P15056-1",
                "P27448-5",
                "Q7Z569-1",
                "P01112-1",
                "Q8IVT5-1",
                "Q16584-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8936731",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8936731"
                }
            ]
        },
        {
            "id": "R-HSA-8941613",
            "name": "Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "RAS nucleotide is stimulated downstream of activated FGFR4 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation  is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P22455-1",
                "Q06124-2",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8941613",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8941613"
                }
            ]
        },
        {
            "id": "R-HSA-8941618",
            "name": "Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "RAS nucleotide is stimulated downstream of activated FGFR2 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation  is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q06124-2",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8941618",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8941618"
                }
            ]
        },
        {
            "id": "R-HSA-8941623",
            "name": "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "RAS nucleotide is stimulated downstream of activated FGFR1 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation  is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q06124-2",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8941623",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8941623"
                }
            ]
        },
        {
            "id": "R-HSA-8941628",
            "name": "Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange",
            "equation": "",
            "summary": "RAS nucleotide is stimulated downstream of activated FGFR3 in a p-PTPN11-dependent manner. The phosphatase activity of PTPN11 is required for activation of the RAS-MAP kinase pathway, although the mechanism for RAS pathway activation  is not yet clear (Hadari et al, 1998; reviewed in Mohi et al, 2007; Gotoh et al, 2008).",
            "cellular_location": "cytosol, extracellular region, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q06124-2",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8941628",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8941628"
                }
            ]
        },
        {
            "id": "R-HSA-8981353",
            "name": "RASA1 stimulates RAS GTPase activity",
            "equation": "",
            "summary": "The intrinsic GTPase activity of RAS proteins is stimulated by the GAP protein RASA1 (reviewed in King et al, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8981353",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8981353"
                }
            ]
        },
        {
            "id": "R-HSA-8981355",
            "name": "RASA1 binds RAS:GTP",
            "equation": "",
            "summary": "The human genome encodes at least 10 proteins that bind RAS and activate its intrinsic GTPase activity, resulting in the formation of inactive RAS:GDP and attenuating RAS signaling (reviewed in King et al, 2013). One of the identified RAS GAP proteins is RASA1, also known as p120 GAP. GAP proteins stimulate RAS GTPase activity by inserting a conserved arginine residue into the RAS active site, promoting a conformational change in the active site to allow GTP hydrolysis (Ahamdian et al, 2003; Scheffzek et al, 1997; Ahamdian et al, 1997). In addition to the GAP domain, most RAS GAP proteins also contain membrane targeting domains that facilitate interaction with the plasma membrane where RAS is tethered.  In some cases, such as RASA3, membrane localization is constitutive, whereas in others, the GAP proteins are targeted to the membrane in response to cellular signaling.  In addition to binding RAS, a number of GAP proteins also mediate other protein-protein interactions and act as scaffolds to integrate signaling; some GAPs are also known to bind and activate other small GTPases such as RAP (reviewed in King et al, 2013).  Loss-of-functions mutations in RAS GAP proteins have been identified in a number of cancers (reviewed in Maertens and Cichowski, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-8981355",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8981355"
                }
            ]
        },
        {
            "id": "R-HSA-9026891",
            "name": "NTRK2 activates RAS signaling through SHC1",
            "equation": "",
            "summary": "SHC1-mediated recruitment of GRB2:SOS1 to the activated NTRK2 (TRKB) receptor leads to activation of RAS signaling and downstream phosphorylation of ERK1 (MAPK3) and ERK2 (MAPK1) (Chan et al. 2001). SOS1 functions as a guanine-nucleotide exchange factor for RAS proteins, catalyzing exchange of GDP for GTP, resulting in formation of the active RAS:GTP complex (Chardin et al. 1993).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q16620-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9026891",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9026891"
                }
            ]
        },
        {
            "id": "R-HSA-9029158",
            "name": "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS",
            "equation": "",
            "summary": "SOS1 and phospho-VAV1 bound to GRB2 in a complex with the activated EPOR catalyze the exchange of GDP for GTP bound to RAS proteins, yielding RAS:GTP (Komatsu et al. 1992, Torti et al. 1992). RAS:GTP then activates RAF1 and ERK1 and ERK2. EPO is observed to activate HRAS (Komatsu et al. 1992, Torti et al. 1992), KRAS, and NRAS (inferred from mouse homologs). KRAS appears to be particularly important for erythropoiesis since deletion of KRAS causes anemia in mouse.",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O60674-1",
                "P07948-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9029158",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9029158"
                }
            ]
        },
        {
            "id": "R-HSA-9032067",
            "name": "NTRK2 activates RAS signaling through FRS2",
            "equation": "",
            "summary": "FRS2 is involved in TRKB-mediated activation of RAS signaling. The exact mechanism has not been elucidated. It is likely that SOS1, in complex with GRB2, recruited to activated NTRK2 (TRKB) receptor through phosphorylated FRS2, catalyzes guanine nucleotide exchange on RAS (HRAS, KRAS or NRAS), resulting in formation of the active RAS:GTP complex and initiation of RAS/RAF/MAPK signaling. PTPN11 (SHP2) facilitates FRS2-mediated activation of RAS downstream of NTRK2, possibly by contributing to GRB2 recruitment (Easton et al. 1999, Easton et al. 2006).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q16620-1",
                "Q06124-2",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9032067",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9032067"
                }
            ]
        },
        {
            "id": "R-HSA-9036970",
            "name": "NTRK3 activates RAS through SHC1",
            "equation": "",
            "summary": "Stimulation of NTRK3 (TRKC) by recombinant human NTF3 (NT-3) increases the amount of GTP-bound RAS (Marsh and Palfrey 1996). Activation of RAS targets MAPK3 (ERK1) and MAPK1 (ERK2) was shown to depend on SHC1-mediated recruitment of GRB2 to activated NTRK3 (Gunn-Moore et al. 1997, Yuen and Mobley 1999).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "Q16288-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9036970",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9036970"
                }
            ]
        },
        {
            "id": "R-HSA-9607304",
            "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3",
            "equation": "",
            "summary": "Son of sevenless homolog 1 (SOS1) is the guanine nucleotide exchange factor (GEF) for rat sarcoma (RAS) protein. SOS1 activates RAS nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P36888-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9607304",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9607304"
                }
            ]
        },
        {
            "id": "R-HSA-9632906",
            "name": "PRKCZ recruits RAS in response to estrogen stimulation",
            "equation": "",
            "summary": "RAS is recruited to a complex that also contains SRC, PRKCZ and the p85 subunit of PI3K in response to estrogen stimulation (Castoria et al, 2004). RAS signaling downstream of ESR1 contributes to cell cycle progression through the induction of cyclin D transcription and the nuclear export of CDKN1B (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Rodier et al, 2002; reviewed in Castoria et al, 2010; Arnal et al, 2017).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O15530-1",
                "Q05513-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9632906",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9632906"
                }
            ]
        },
        {
            "id": "R-HSA-9632910",
            "name": "ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus",
            "equation": "",
            "summary": "MAPK1 (also known as ERK2) translocates to the nucleus in response to estrogen stimulation several cell lines in a manner that also depends on SRC, PI3K and PRCKZ (Castoria et al, 2004). RAS signaling and ERK2 nuclear translocation promotes estrogen-dependent stimulation of cell cycle progression (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Castoria et al, 2004; Rodier et al, 2002; Foster et al, 2003;reviewed in Castoria et al, 2010).",
            "cellular_location": "cytosol, nucleoplasm",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O15530-1",
                "Q05513-1",
                "P28482-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9632910",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9632910"
                }
            ]
        },
        {
            "id": "R-HSA-9632918",
            "name": "PRKCZ stimulates RAS nucleotide exchange in response to estrogen",
            "equation": "",
            "summary": "Estrogen stimulation promotes nucleotide exchange on RAS in a number of cell lines, leading to RAS signaling and cell cycle progression (Atkas et al, 1997; Cheng et al, 1998; Kawada et al, 1997; Castoria et al, 1999; Castoria et al, 2001). RAS activation depends on recruitment of SRC, PI3K and PRKCZ, and the complex likely also includes SOS, although this has not been explicitly demonstrated (Migliaccio et al, 1996; Castoria et al, 2004; reviewed in Castoria et al, 2010).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O15530-1",
                "Q05513-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9632918",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9632918"
                }
            ]
        },
        {
            "id": "R-HSA-9634418",
            "name": "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1",
            "equation": "",
            "summary": "Based on activation of RAS signaling by autophosphorylated ERBB2 homodimers, as well as binding of GRB2 and SHC1 to ERBB2 homodimers (Pickl and Ries 2009), it is assumed that SOS1, recruited to ERBB2 homodimers through GRB2, mediates GDP to GTP exchange on RAS protein family, resulting in formation of the active RAS:GTP complex.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9634418",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9634418"
                }
            ]
        },
        {
            "id": "R-HSA-9647977",
            "name": "ICMT methylates S-Farn RAS proteins",
            "equation": "",
            "summary": "RAS proteins undergo C-terminal carboxymethylation by isoprenylcysteine methyltransferase (ICMT) (Yang et al, 2011; Dharmaiah et al, 2016; reviewed in Gysin et al, 2011; Ahearn et al, 2018). LIke prenylation, methylation is required for plasma membrane localization and function of RAS proteins, and disruption of ICMT or interference with the methylation reaction inhibits cell growth and KRAS-dependent transformation (Chiu et al, 2004; Michaelson et al, 2005; Bergo et al, 2004; Wahlstrom et al, 2008; Winter-Vann et al, 2003). Consistent with this, a number of small molecule inhibitors of ICMT have been shown to decrease tumor proliferation (Wang et al, 2009; Manu et al, 2017; Sun et al, 2016).",
            "cellular_location": "endoplasmic reticulum membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "O60725-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9647977",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647977"
                }
            ]
        },
        {
            "id": "R-HSA-9647978",
            "name": "pro-RAS proteins are farnesylated",
            "equation": "",
            "summary": "RAS proteins are isoprenylated at a CaaX motif in the hypervariable region, where a is an aliphatic amino acid and X is any amino acid (Casey et al, 1989; Dharmaiah et al, 2016; reviewed in Ahean et al, 2018). Geranylgeranylation is favoured when X is leucine, while all other amino acids at this position favour farnesylation by farnesyltransferase (Casey et al, 1989; Reid et al, 2004).",
            "cellular_location": "cytosol, endoplasmic reticulum membrane",
            "input_participant_list": [
                "R-ALL-2530486"
            ],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P49354-1",
                "P01112-1",
                "P49356-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9647978",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647978"
                }
            ]
        },
        {
            "id": "R-HSA-9647980",
            "name": "mature RAS proteins translocate to plasma membrane",
            "equation": "",
            "summary": "After farnesylation, C-terminal proteolysis, carboxymethylation and palmitoylation, RAS proteins translocate to the plasma membrane (reviewed in Gysin et al, 2011).",
            "cellular_location": "Golgi membrane, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9647980",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647980"
                }
            ]
        },
        {
            "id": "R-HSA-9647982",
            "name": "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated",
            "equation": "",
            "summary": "After carboxymethylation, HRAS, NRAS and KRAS4A are palmitoylated on cysteine residues upstream of the CaaX motif (residue C179 in KRAS4A, C181 in NRAS and C181 and C184 in HRAS). KRAS4B lacks upstream cysteine residues and does not undergo palmitoylation (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Ahearn et al, 2018). Palmitoylation is catalyzed by the DHHC9:GOLGA7 complex at the Golgi membrane (Swarthout et al, 2008).",
            "cellular_location": "Golgi membrane, endoplasmic reticulum membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q9Y397-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9647982",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647982"
                }
            ]
        },
        {
            "id": "R-HSA-9647994",
            "name": "RAS proteins are depalmitoylated",
            "equation": "",
            "summary": "RAS proteins undergo a dynamic palmitoylation and depalmitoylation cycle that regulates their association with membranes and thus their localization and function (Hancock et al, 1989; Swarthout et al, 2005; reviewed in Gysin et al, 2011; Lin et al, 2017; Ahearn et al, 2018). Depalmitoylation is catalyzed by the acyl-protein thioesterase LYPLA1, also known as APT1, or by members of the ABHD17 family (Dekker et al, 2010; Lin and Conibear, 2015; reviewed in Lin et al, 2017).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [
                "R-ALL-8848337"
            ],
            "enzyme_list": [
                "P01111-1",
                "Q5VST6-1",
                "Q6PCB6-1",
                "Q96GS6-1",
                "P01112-1",
                "O75608-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9647994",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647994"
                }
            ]
        },
        {
            "id": "R-HSA-9647999",
            "name": "RCE1 cleaves S-Farn proRAS proteins",
            "equation": "",
            "summary": "After prenylation, RAS proteins undergo C-terminal endoproteolysis by RAS-converting enzyme I (RCE1), which removes the aaX residues of the CaaX motif (Otto et al, 1999; Hollander et al, 2000; reviewed in Hampton et al, 2018; Ahearn et al, 2018). RCE1-mediated cleavage is required for RAS plasma membrane localization and function (Michaelson et al, 2005). RCE1 is ubiquitinated in its active form, and deubiquitination by USP17L2 abrogates its catalytic activity and inhibits signaling through the RAS-RAF MAP kinase pathway (Burrows et al, 2009). RCE1 has thus been investigated as a potential therapeutic target in RAS driven disease. Despite some promising studies, the effects of RCE1 inactivation appear unpredictable and can lead to unexpected activation of RAS signaling through mechanisms that are not fully understood (Bergo et al, 2002; Aiyagari et al, 2003; Kim et al, 1999; Chen et al, 1998; Chen et al, 1999; Wahlstrom et al, 2007).",
            "cellular_location": "endoplasmic reticulum membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "Q9Y256-1",
                "P01112-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9647999",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647999"
                }
            ]
        },
        {
            "id": "R-HSA-9649733",
            "name": "mature p21 RAS binds GDP",
            "equation": "",
            "summary": "RAS proteins bind GDP with picomolar affinity as part of the RAS:GTP cycle (reviewed in Hennig et al, 2015; Pei et al, 2019; Prior et al, 2012).  RAS proteins in the GDP-bound form are inactive. Interaction with guanine nucleotide exchange factors (GEFs) enhances the slow rate of intrinsic GDP dissociation, allowing GTP to bind and activate the protein (reviewed in Henning et al, 2015).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9649733",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649733"
                }
            ]
        },
        {
            "id": "R-HSA-9649735",
            "name": "Intrinsic nucleotide exchange on RAS",
            "equation": "",
            "summary": "Inactive RAS:GDP is converted at a low rate to the active GTP-bound state through release of GDP and binding of GTP. This intrinsic GEF activity is weak due to the picomolar affinity of the protein for both nucleotides, but is stimulated by the interaction of RAS proteins with guanine nucleotide exchange factors (Marshall et al, 2012; reviewed in Bourne et al, 1991; Hennig et al, 2015; Pei et al, 2018).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9649735",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649735"
                }
            ]
        },
        {
            "id": "R-HSA-9649736",
            "name": "RAS intrinsic GTPase activity hydrolyzes GTP to GDP",
            "equation": "",
            "summary": "RAS proteins have weak intrinsic GTPase activity in the absence of other effectors (Gibbs et al, 1984; reviewed in Pylayeva-Gupta et al, 2011). Nucleotide attack is mediated by residue Q61 and facilitated by van der Waals bonds contributed by glycine residues at position 12 and 13; these three residues account for the majority of oncogenic and pathogenic mutations found in RAS proteins (reviewed in Prior et al, 2012). GAP proteins stimulate the intrinsic GTPase activity of RAS proteins by inserting an arginine residue into the active site, which contributes to proper positioning of the critical Q61 RAS residue (reviewed in King et al, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9649736",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9649736"
                }
            ]
        },
        {
            "id": "R-HSA-9651280",
            "name": "RAS GAP mutants aren't stimulated by GAPs",
            "equation": "",
            "summary": "RAS GAP proteins interact with RAS by inserting an arginine finger into the RAS active site to promote positioning of the catalytic Q61 residue, stimulating the low intrinsic GTPase activity by several orders of magnitude (Ahmadian et al, 2003; Ahmadian et al, 1997; reviewed in Bos et al, 2007). ; Many of the common mutations in RAS proteins found in cancer interfere with the ability of RAS GAPs to stimulate the intrinsic GTPase of the proteins. Mutation of the catalytic Q61 disrupts coordination of a water molecule that is required for nucleophilic attack on the gamma phosphate of GTP, while G12 and G13 mutations abrogate interactions with RAS GAP proteins that are required for proper positioning of the Q61 residue (Trahey et al, 1987; Scheidig et al, 1999; Buhrman et al, 2010; Scheffzek et al,1997). <br>In addition to somatic mutations in cancer, RAS is also subject to germline mutations that lead to a group of developmental disorders collectively known as RASopathies (reviewed in Rauen, 2013; Tidyman and Rauen, 2009). Like their oncogenic counterparts, these RAS mutants show defective GTP hydrolysis and constitutive signaling (Schubbert et al, 2006; Schubbert et al, 2007).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P01116-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9651280",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9651280"
                }
            ]
        },
        {
            "id": "R-HSA-9653108",
            "name": "Raf dimer inhibitors bind RAF heterodimers",
            "equation": "",
            "summary": "LY3009120, TAK-580 and TAK-632 are pan-RAF inhibitors that binds to all 3 RAF isoforms as well as to RAF dimers to inhibit phosphorylation of MAP2K and MAPK proteins (Nakamura et al, 2013; Okaniwa et al, 2013; Sun et al, 2017; Peng et al, 2015; Henry et al, 2015; Vakana et al, 2017). Because they inhibit the kinase activity of RAF homo- and heterodimers, treatment with pan-RAF dimer inhibitors generates minimal paradoxical RAF activation and inhibits cellular proliferation in a number of tumor models (Peng et al, 2015; Henry et al, 2015, Vakana et al, 2017; reviewed in Karoulia et al, 2017; Agianian and Gavathiotis, 2018; ).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P01112-1",
                "Q8IVT5-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9653108",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9653108"
                }
            ]
        },
        {
            "id": "R-HSA-9656209",
            "name": "Dissociation of RAS:RAF1 mutant complex",
            "equation": "",
            "summary": "After phosphorylation of MAPKs by complexes containing RAF1 mutants, activated MAPK signaling complexes dissociate in a manner similar to wildtype, although this has not been explicitly demonstrated in all cases. Active complexes may signal from other cellular locations or may amplify signaling through rounds of heterodimerization with other inactive RAF monomers (reviewed in Matallanas et al, 2011; Cseh et al, 2014).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9656209",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656209"
                }
            ]
        },
        {
            "id": "R-HSA-9656211",
            "name": "MAP2Ks and MAPKs bind to the activated mutant RAF1 complex",
            "equation": "",
            "summary": "MAP2K and MAPK proteins are likely recruited to complexes containing mutant versions of RAF1 proteins, analagous to the wild type pathway, although this has not been explicitly demonstrated in all cases (reviewed in Rauen, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9656211",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656211"
                }
            ]
        },
        {
            "id": "R-HSA-9656212",
            "name": "Phosphorylation of RAF1 mutants",
            "equation": "",
            "summary": "RAF1 mutants in cancer and germline disorders such as Noonan syndrome undergo enhanced dimerization and activation with BRAF, leading to high levels of downstream signaling. This has been observed even in cases of RAF1 mutations with abrogated or impaired kinase activity (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012; Krauthammer et al, 2015; reviewed in Rauen, 2013).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "O60674-1",
                "Q9UQM7-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "Q13554-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q13557-1",
                "Q13555-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9656212",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656212"
                }
            ]
        },
        {
            "id": "R-HSA-9656213",
            "name": "RAF1 mutants show enhanced heterodimerization with BRAF",
            "equation": "",
            "summary": "Mutations in RAF1 are common in RASopathies such as Noonan Syndrome, Costello Syndrome, LEOPARD Syndrome and others, and also occur at low frequency in some cancers (reviewed in Rauen, 2013; Samatar and Poulikakos, 2014). Germline mutations of RAF1 cluster in three regions: conserved region 2 (CR2) surrounding phosphorylation site S259, the activation segment, or conserved region 3 (CR3). Mutations in CR2 abrogate binding with 14-3-3 proteins and relieve this inhibitory interaction, increasing the downstream signaling presumably through increased availability of RAF1 for heterodimerization with BRAF (Kobayashi et al, 2010; Pandit et al, 2007; Razzaque et al, 2007; Krauthammer et al, 2015). Increased heterodimerization with BRAF has also been demonstrated for RAF1 proteins with mutations in CR3 and the activation domain, including for RAF1 mutants with decreased or absent kinase activity (Pandit et al, 2007; Wu et al, 2012).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P01112-1",
                "Q8IVT5-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9656213",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656213"
                }
            ]
        },
        {
            "id": "R-HSA-9656214",
            "name": "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants",
            "equation": "",
            "summary": "MAPK proteins are phosphorylated downstream of RAF1 mutants (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9656214",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656214"
                }
            ]
        },
        {
            "id": "R-HSA-9656215",
            "name": "RAF1 mutant complexes phosphorylate MAP2K dimer",
            "equation": "",
            "summary": "MAPK2Ks are phosphorylated downstream of mutant RAF1 proteins (Razzaque et al, 2007; Pandit et al, 2007; Kobayashi et al, 2010; Wu et al, 2012).",
            "cellular_location": "plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9656215",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656215"
                }
            ]
        },
        {
            "id": "R-HSA-9657599",
            "name": "Dual mechanism MAP2K inhibitors bind MAP2Ks",
            "equation": "",
            "summary": "Although mutations in MAP2K proteins are infrequent in human cancers, the position of these kinases downstream of RAS and RAF make them good candidates for therapeutic targeting. Dual mechanism inhibitors such as trametinib bind to non-phosphorylated MAP2K proteins, inhibiting their MAPK-directed kinase activity as well as preventing their phosphorylation by RAF proteins (Hatzivassiliou et al, 2013; Lito et al, 2014; Ishii et al, 2013; reviewed in Samatar and Poulikakos, 2014).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9657599",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657599"
                }
            ]
        },
        {
            "id": "R-HSA-9657603",
            "name": "Dual mechanism MAPK inhibitors bind MAPKs",
            "equation": "",
            "summary": "A number of 'dual mechanism' MAPK inhibitors are in preclinical or clinical trials (reviewed in Roskoski, 2019). Dual mechanism inhibitors, including the ATP-competitive inhibitors SCH772984 and MK-8353, bind to the unphosphorylated MAPK and prevent both its own kinase activity and its phosphorylation by MAP2Ks (Morris et al, 2013; Deng et al 2014; Chaikuad et al, 2014; Boga et al, 2018; Moschos et al, 2019; reviewed in Samatar and Poulikakos, 2014). MAPK inhibitors offer the potential to mitigate the development of resistance to RAF and MAP2K inhibitors, which often involves reactivation of MAPK-dependent signaling. As a result, MAPK inhibitors are frequently used in combination with RAF and MAP2K-directed therapeutics (reviewed in Samatar and Poulikakos, 2014; Roskoski, 2019).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9657603",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657603"
                }
            ]
        },
        {
            "id": "R-HSA-9657606",
            "name": "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks",
            "equation": "",
            "summary": "Single mechanism MAP2K inhibitors bind to phosphorylated forms of MAP2K 1 and 2 and prevent their phosphorylation of MAPK proteins (Hatzivassiliou et al, 2013; reviewed in Samatar and Poulikakos, 2014).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9657606",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657606"
                }
            ]
        },
        {
            "id": "R-HSA-9657608",
            "name": "Single mechanism MAPK inhibitors bind phosphorylated MAPK",
            "equation": "",
            "summary": "Single mechanism MAPK inhibitors such as ulixertinib and ravoxertinib bind to the activated forms of MAPK proteins and inhibit their intrinsic target-directed kinase activity (Germann et al, 2017; Blake et al, 2016; reviewed in Samatar and Poulikakos, 2014).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P27361-1",
                "P41240-1",
                "P61224-1",
                "P62834-1",
                "P12931-1",
                "P04049-1",
                "P10398-1",
                "P15056-1",
                "P27448-5",
                "P60709-1",
                "P63261-1",
                "P28482-1",
                "P01112-1",
                "P36507-1",
                "Q8IVT5-1",
                "Q02750-1",
                "Q6VAB6-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9657608",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9657608"
                }
            ]
        },
        {
            "id": "R-HSA-9658253",
            "name": "RAS:GTP binds PI3K",
            "equation": "",
            "summary": "GTP-bound RAS interacts with PI3K through a direct interaction with the 110 kDa catalytic subunit (Sjolander et al, 1991; Rodriguez-Viciana et al, 1994; Rodriguex-Viciana et al, 1996; Pacold et al, 2000; reviewed in Gysin et al, 2011; Castellano and Downward, 2011; Martini et al, 2014). Interaction with RAS stimulates the activity of PI3K by promoting a conformational change and/or mediating recruitment to the plasma membrane, among other possible mechanisms (Pacold et al, 2000; Denley et al, 2008; Zhang et al, 2019). The PI3K signaling pathway contributes to RAS-mediated cellular proliferation and survival and through RAC, contributes to cytoskeletal rearrangements and cell motility (reviewed in Vivanco and Sawyers, 2002; Castellano and Downward, 2011; Martini et al, 2014; Nussinov et al, 2015).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P42336-1",
                "P01112-1",
                "P42338-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9658253",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9658253"
                }
            ]
        },
        {
            "id": "R-HSA-9660557",
            "name": "RAS:GTP binds RAL GDS proteins",
            "equation": "",
            "summary": "RAL GDS and related family members RGL1, 2 and 3 are small GTPase proteins in the RAS family that act as effectors downstream of HRAS and other RAS proteins (reviewed in Ferro and Trabalzini, 2010; Gentry et al, 2014). RALGDS family members bind to HRAS in the GTP-bound state through the RALGDS Ras binding domains (RBDs) and acts as RAL A and RAL B-specific guanine nuclear exchange factors (GEFs) (Hofer et al, 1994; Spaargen et al, 1994; Kikuchi et al, 1994; Wolthius et al, 1996; Peterson et al, 1996; Shao et al, 2000; Ehrhardt et al, 2001; reviewed in Gentry et al, 2014).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9660557",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9660557"
                }
            ]
        },
        {
            "id": "R-HSA-9664991",
            "name": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants",
            "equation": "",
            "summary": "For the following ERBB2 KD mutants that were shown to activate RAS/RAF/MAPK signaling, it is assumed that they, like phosphorylated heterodimers of the wild type ERBB2, bind to and phosphorylate SHC1, leading to recruitment of the GRB2:SOS1 complex and activating guanyl-nucleotide exchange on RAS:<br><br>ERBB2 L755P (Kancha et al. 2011);<br>ERBB2 L755S (Trowe et al. 2008, Kancha et al. 2011, Bose et al. 2013, Cocco et al. 2018);<br>ERBB2 I767M (Ng et al. 2015);<br>ERBB2 D769H (Bose et al. 2013);<br>ERBB2 V777L (Kancha et al. 2011, Bose et al. 2013);<br>ERBB2 G778_P780dup (Suzawa et al. 2016);<br>ERBB2 T798I (Hanker et al. 2017);<br>ERBB2 T798M (Kancha et al. 2011, Rexer et al. 2013);<br>ERBB2 V842I (Bose et al. 2013);<br>ERBB2 T862A (Kancha et al. 2011);<br>ERBB2 L869R (Hanker et al. 2017);<br>ERBB2 H878Y (Kancha et al. 2011, Hu, Hu et al. 2015, Hu, Wan et al. 2015);<br>ERBB2 R896C (Bose et al. 2013);<br>ERBB2 L755_T759del (Bose et al. 2013);<br>ERBB2 G776S (Fan et al. 2008);<br>ERBB2 Y772_A775dup (Wang et al. 2006);<br><br>Activation of RAS/RAF/MAPK signaling downstream of the following ERBB2 KD cancer mutants has not been studied and they are annotated as candidates:<br><br>ERBB2 L755M <br>ERBB2 L755W<br>ERBB2 D769Y<br>ERBB2 D769N<br>ERBB2 V777M<br>ERBB2 V777E<br>ERBB2 T733I<br>ERBB2 V842E<br>ERBB2 L869Q<br>ERBB2 H878R<br>ERBB2 R896H<br>ERBB2 G776C<br>ERBB2 G776L<br>ERBB2 G776V",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9664991",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9664991"
                }
            ]
        },
        {
            "id": "R-HSA-9665009",
            "name": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR",
            "equation": "",
            "summary": "The following EGFR-binding ERBB2 KD mutants that were shown to activate RAS/RAF/MAPK signaling, evidenced by activating phosphorylation of ERKs (MAPK1 and MAPK3), are assumed to, like the wild type ERBB2:EGFR heterodimer, directly bind to the GRB2:SOS1 complex, leading to activating guanyl nucleotide exchange on RAS:<br><br>ERBB2 L755S (Trowe et al. 2008, Kancha et al. 2011, Bose et al. 2013, Cocco et al. 2018);<br>ERBB2 L755P (Kancha et al. 2011);<br>ERBB2 I767M (Ng et al. 2015; binding to EGFR indirectly demonstrated by Bose et al. 2013);<br>ERBB2 D769H (Bose et al. 2013);<br>ERBB2 V777L (Kancha et al. 2011, Bose et al. 2013);<br>ERBB2 G778_P780dup (Suzawa et al. 2016);<br>ERBB2 T798M (Kancha et al. 2011, Rexer et al. 2013);<br>ERBB2 T798I (Hanker et al. 2017);<br>ERBB2 V842I (Bose et al. 2013);<br>ERBB2 T862A (Kancha et al. 2011);<br>ERBB2 H878Y (Kancha et al. 2011, Hu, Hu et al. 2015, Hu, Wan et al. 2015);<br>ERBB2 R896C (Bose et al. 2013);<br>ERBB2 L755_T759del (Bose et al. 2013);<br>ERBB2 Y772_A775dup (Wang et al. 2006);<br><br>Activation of RAS/RAF/MAPK signaling downstream of the following ERBB2 KD cancer mutants has not been studied and they are annotated as candidates:<br><br>ERBB2 L755M<br>ERBB2 L755W<br>ERBB2 D769Y<br>ERBB2 D769N<br>ERBB2 V777M<br>ERBB2 V777E<br>ERBB2 T733I<br>ERBB2 V842E<br>ERBB2 H878R<br>ERBB2 R896H",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9665009",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665009"
                }
            ]
        },
        {
            "id": "R-HSA-9665404",
            "name": "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1",
            "equation": "",
            "summary": "RAS signaling is activated dowsntream of ERBB2 ECD mutants ERBB2 G309A (Bose et al. 2013), ERBB2 G309E (Greulich et al. 2012) and ERBB2 S310F (Greulich et al. 2012), as evidenced by activating phosphorylation of ERKs (MAPK1 and MAPK3). It is assumed that phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, like phosphorylated heterodimers of the wild type ERBB2, can recruit the GRB2:SOS1 complex through phosphorylated SHC1, leading to  guanyl nucleotide exchange on RAS and activation of RAS signaling.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9665404",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665404"
                }
            ]
        },
        {
            "id": "R-HSA-9665408",
            "name": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2",
            "equation": "",
            "summary": "RAS signaling is activated dowsntream of ERBB2 ECD mutants ERBB2 G309A (Bose et al. 2013), ERBB2 G309E (Greulich et al. 2012) and ERBB2 S310F (Greulich et al. 2012), as evidenced by activating phosphorylation of ERKs (MAPK1 and MAPK3). It is assumed that phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, like phosphorylated heterodimers of the wild type ERBB2, can directly recruit the GRB2:SOS1 complex, leading to  guanyl nucleotide exchange on RAS and activation of RAS signaling.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9665408",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665408"
                }
            ]
        },
        {
            "id": "R-HSA-9665700",
            "name": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants",
            "equation": "",
            "summary": "Activation of downstream RAS signaling was shown for ERBB2 S653C (de Martino et al. 2014) and ERBB2 R678Q (Bose et al. 2013, de Martino et al. 2014) through activating tyrosine phosphorylation on ERKs (MAPK1 and MAPK3) and SHC1.  It is assumed that heterodimers of ERBB2 TMD/JMD mutants, like the wild type ERBB2 heterodimers, bind to and phosphorylate SHC1, leading to the recruitment of the GRB2:SOS1 complex and activation of RAS through guanyl nucleotide exchange.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9665700",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665700"
                }
            ]
        },
        {
            "id": "R-HSA-9665707",
            "name": "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR",
            "equation": "",
            "summary": "Activation of downstream RAS signaling was shown for ERBB2 S653C (de Martino et al. 2014) and ERBB2 R678Q (Bose et al. 2013, de Martino et al. 2014) through activating tyrosine phosphorylation on ERKs (MAPK1 and MAPK3). It is assumed that heterodimers of ERBB2 TMD/JMD mutants and EGFR, like the wild type ERBB2:EGFR heterodimers, directly bind to GRB:SOS1 complex, resulting in activation of RAS signaling to guanyl nucleotide exchange on RAS.",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P00533-1",
                "P04626-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9665707",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9665707"
                }
            ]
        },
        {
            "id": "R-HSA-9670436",
            "name": "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS",
            "equation": "",
            "summary": "Activation of the MAP kinase signaling pathway downstream of oncogenic KIT mutants, as evidenced by the presence of phosphorylated ERK proteins, likely depends on the SOS-mediated nucleotide exchange of GDP for GTP on RAS, as is the case for the wild-type receptor (Frost et al, 2002; Chi et al, 2010; Garner et al, 2014; Monsel et al, 2010; Obata et al, 2017; reviewed in Abbaspour Babaei et al, 2016; Lennartsson and Roonstrand, 2012).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P10721-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9670436",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9670436"
                }
            ]
        },
        {
            "id": "R-HSA-9672163",
            "name": "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers",
            "equation": "",
            "summary": "SOS-mediated nucleotide exchange on RAS is likely promoted by extracellular domain mutants of PDGFRA, as evidenced by the increased levels of phosphorylated MAPK/ERK proteins, although the details have not been fully demonstrated (Ozawa et al, 2010; Ip et al, 2018).",
            "cellular_location": "cytosol, endoplasmic reticulum membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P16234-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9672163",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672163"
                }
            ]
        },
        {
            "id": "R-HSA-9672170",
            "name": "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors",
            "equation": "",
            "summary": "SOS-mediated exchange of GTP for GDP on RAS is predicted to be stimulated by gain-of-function PDGFRA mutants, based on the increased levels of phosphorylated MAPK3 and MAPK1 proteins (ERK1 and ERK2, respectively) (Heinrich et al, 2003; Corless et al, 2005; Ohashi et al, 2004; Velghe et al, 2014; reviewed in Corless et al, 2011; Roskoski, 2018).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P16234-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9672170",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9672170"
                }
            ]
        },
        {
            "id": "R-HSA-9695853",
            "name": "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS",
            "equation": "",
            "summary": "SOS1-mediated nucleotide exchange on RAS downstream of activated FLT3 mutants leads to stimulation of the MAP kinase signaling cascade (Mizuki et al, 2000; Hayakawa et al, 2000; Masson et al, 2009; reviewed in Kazi and Ronnstrand, 2019).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1",
                "P36888-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9695853",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9695853"
                }
            ]
        },
        {
            "id": "R-HSA-9703441",
            "name": "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants",
            "equation": "",
            "summary": "SOS1-mediated nucleotide exchange on RAS is presumed to occur downstream of activated FLT3 fusion mutants, leading to increased phosphorylation of MAPK/ERK proteins (Grand et al, 2007; Vu et al, 2009; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Roonstrand et al, 2019).",
            "cellular_location": "cytosol, plasma membrane",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "P01111-1",
                "P01112-1"
            ],
            "evidence": [
                {
                    "id": "R-HSA-9703441",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9703441"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-ALL-2530486",
            "participant_name": "FPP [cytosol]",
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                {
                    "id": "000013507236",
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                },
                {
                    "id": "50277",
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        },
        {
            "participant_id": "R-ALL-8848337",
            "participant_name": "PALM(-) [cytosol]",
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                {
                    "id": "7896",
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                {
                    "id": "7896",
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                    "url": ""
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                {
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                }
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                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                            "database": "UniProtKB",
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                    "ec_number": "3.6.5.-",
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                            "database": "UniProtKB",
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                }
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                            "database": "UniProtKB",
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                            "database": "UniProtKB",
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                }
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                    "ec_number": "3.6.5.2",
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                    ]
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                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.3",
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                            "database": "UniProtKB",
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                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.3",
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                            "database": "UniProtKB",
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        {
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        {
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                {
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        {
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                    "ec_number": "3.6.5.2",
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                            "id": "O00194",
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                    "ec_number": "3.6.5.5",
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                    "ec_number": "3.6.5.2",
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                    "ec_number": "3.6.5.2",
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                    "ec_number": "3.6.5.2",
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                {
                    "ec_number": "2.3.2.27",
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                {
                    "ec_number": "2.7.11.1",
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                            "id": "O15530",
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                    "ec_number": "3.6.5.2",
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                            "id": "O18333",
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                    ]
                },
                {
                    "ec_number": "3.6.5.2",
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                            "id": "O18333",
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                    ]
                }
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        {
            "uniprot_ac": "O18412",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "O18412",
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                    ]
                }
            ]
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        {
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                    "ec_number": "3.6.5.5",
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                    "ec_number": "3.6.5.5",
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                            "id": "O35303",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O35303"
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "O35509",
                            "database": "UniProtKB",
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                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
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                            "id": "O35509",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O35509"
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                {
                    "ec_number": "3.6.5.5",
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                            "id": "O60313",
                            "database": "UniProtKB",
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                    ]
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                {
                    "ec_number": "3.6.5.5",
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                        {
                            "id": "O60313",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O60313"
                        }
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                }
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                {
                    "ec_number": "2.7.10.2",
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                            "id": "O60674",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O60674"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.10.2",
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                            "id": "O60674",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O60674"
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                {
                    "ec_number": "2.1.1.100",
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                            "id": "O60725",
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                },
                {
                    "ec_number": "2.1.1.100",
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                            "id": "O60725",
                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "O60841",
                            "database": "UniProtKB",
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                        }
                    ]
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                {
                    "ec_number": "3.6.5.3",
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                        {
                            "id": "O60841",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O60841"
                        }
                    ]
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                {
                    "ec_number": "3.1.2.22",
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                        {
                            "id": "O75608",
                            "database": "UniProtKB",
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                        }
                    ]
                },
                {
                    "ec_number": "3.1.2.22",
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                        {
                            "id": "O75608",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O75608"
                        }
                    ]
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                {
                    "ec_number": "3.1.2.-",
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                    "evidence": [
                        {
                            "id": "O75608",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O75608"
                        }
                    ]
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                {
                    "ec_number": "2.7.11.1",
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                        {
                            "id": "O75914",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/O75914"
                        }
                    ]
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                {
                    "ec_number": "2.7.11.1",
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                        {
                            "id": "O75914",
                            "database": "UniProtKB",
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                        }
                    ]
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "O76742",
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                        }
                    ]
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                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "O76742",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "O94811",
                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "O95140",
                            "database": "UniProtKB",
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                {
                    "ec_number": "2.7.10.1",
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                            "id": "P00533",
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                    ]
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                {
                    "ec_number": "2.7.10.1",
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                        {
                            "id": "P00533",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P01111",
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                    ]
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                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "P01111",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P01112",
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                    ]
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P01112",
                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "P01116",
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                    ]
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                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "P01116",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P01119",
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                    ]
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                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "P01119",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P01120",
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                    ]
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                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "P01120",
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                {
                    "ec_number": "3.6.5.2",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P03967",
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                {
                    "ec_number": "2.7.11.1",
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                            "id": "P04049",
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                {
                    "ec_number": "2.7.11.1",
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                            "id": "P04049",
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                    "ec_number": "3.6.5.2",
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                            "id": "P04388",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P04388",
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                    "ec_number": "2.7.10.1",
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                            "id": "P04626",
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                {
                    "ec_number": "2.7.10.1",
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                            "id": "P04626",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P05197",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P05213",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P05214",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P05453",
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                            "id": "P05712",
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                    "ec_number": "3.6.5.2",
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                            "id": "P05712",
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                    "ec_number": "3.6.5.2",
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                            "id": "P05714",
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                    "ec_number": "3.6.5.2",
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                            "id": "P05714",
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                    "ec_number": "2.7.10.2",
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                            "id": "P06241",
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                    ]
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                {
                    "ec_number": "2.7.10.2",
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                            "id": "P06241",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P06603",
                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.-",
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                            "database": "UniProtKB",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P06605",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P06605"
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        {
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P06606",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P06606"
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                    ]
                }
            ]
        },
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                            "id": "P06780",
                            "database": "UniProtKB",
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                    ]
                },
                {
                    "ec_number": "3.6.5.2",
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                            "id": "P06780",
                            "database": "UniProtKB",
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                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P06781",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                            "id": "P06781",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P06781"
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                    ]
                },
                {
                    "ec_number": "3.6.5.2",
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                            "id": "P06781",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P06781"
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                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P07900",
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                    "ec_number": "3.6.4.10",
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                    "ec_number": "3.6.5.2",
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                        {
                            "id": "P35281",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P35281"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36409",
            "gene_name": "rab2A",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P36409",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36409"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36409",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36409"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36411",
            "gene_name": "rab7A",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P36411",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36411"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36411",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36411"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36507",
            "gene_name": "MAP2K2",
            "activity": [
                {
                    "ec_number": "2.7.12.2",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "P36507",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36507"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.12.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36507",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36507"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36860",
            "gene_name": "Ralb",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P36860",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36860"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36860",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36860"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P36888",
            "gene_name": "FLT3",
            "activity": [
                {
                    "ec_number": "2.7.10.1",
                    "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
                    "evidence": [
                        {
                            "id": "P36888",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36888"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.10.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P36888",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P36888"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P38297",
            "gene_name": "FZO1",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P38297",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P38297"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39052",
            "gene_name": "Dnm2",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P39052",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39052"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39052",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39052"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39053",
            "gene_name": "Dnm1",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P39053",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39053"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39053",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39053"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39054",
            "gene_name": "Dnm2",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P39054",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39054"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39054",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39054"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P39730",
            "gene_name": "FUN12",
            "activity": [
                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P39730",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39730"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P39730",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P39730"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P40793",
            "gene_name": "Cdc42",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P40793",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P40793"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P40793",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P40793"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P41091",
            "gene_name": "EIF2S3",
            "activity": [
                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P41091",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P41091"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P41091",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P41091"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P41240",
            "gene_name": "CSK",
            "activity": [
                {
                    "ec_number": "2.7.10.2",
                    "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
                    "evidence": [
                        {
                            "id": "P41240",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P41240"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.10.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P41240",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P41240"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P42336",
            "gene_name": "PIK3CA",
            "activity": [
                {
                    "ec_number": "2.7.1.153",
                    "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
                    "evidence": [
                        {
                            "id": "P42336",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42336"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.153",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P42336",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42336"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "P42336",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42336"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.137",
                    "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
                    "evidence": [
                        {
                            "id": "P42336",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42336"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.137",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P42336",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42336"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P42338",
            "gene_name": "PIK3CB",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "P42338",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42338"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.153",
                    "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
                    "evidence": [
                        {
                            "id": "P42338",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42338"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.153",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P42338",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42338"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.137",
                    "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
                    "evidence": [
                        {
                            "id": "P42338",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42338"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.137",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P42338",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P42338"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P46638",
            "gene_name": "Rab11b",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P46638",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46638"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P46638",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46638"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P46943",
            "gene_name": "GUF1",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P46943",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P46943"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P48555",
            "gene_name": "Rala",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P48555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P48555"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P48555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P48555"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P49354",
            "gene_name": "FNTA",
            "activity": [
                {
                    "ec_number": "2.5.1.58",
                    "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].",
                    "evidence": [
                        {
                            "id": "P49354",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49354"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.59",
                    "activity": "geranylgeranyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-geranylgeranyl-L-cysteinyl-[protein].",
                    "evidence": [
                        {
                            "id": "P49354",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49354"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.58",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P49354",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49354"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.59",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P49354",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49354"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P49356",
            "gene_name": "FNTB",
            "activity": [
                {
                    "ec_number": "2.5.1.58",
                    "activity": "(2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein].",
                    "evidence": [
                        {
                            "id": "P49356",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49356"
                        }
                    ]
                },
                {
                    "ec_number": "2.5.1.58",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P49356",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49356"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P49961",
            "gene_name": "ENTPD1",
            "activity": [
                {
                    "ec_number": "3.6.1.5",
                    "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.",
                    "evidence": [
                        {
                            "id": "P49961",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49961"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.1.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P49961",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P49961"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P50570",
            "gene_name": "DNM2",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P50570",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50570"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P50570",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P50570"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P51146",
            "gene_name": "Rab4b",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P51146",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51146"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P51146",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51146"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P51148",
            "gene_name": "RAB5C",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P51148",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51148"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P51148",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51148"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P51149",
            "gene_name": "RAB7A",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P51149",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51149"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P51149",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51149"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P51150",
            "gene_name": "Rab7a",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P51150",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51150"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P51150",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P51150"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P51159",
            "gene_name": "RAB27A",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P51159",
                            "database": "UniProtKB",
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                            "url": "https://www.uniprot.org/uniprot/P68369"
                        }
                    ]
                }
            ]
        },
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P68370",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P68370"
                        }
                    ]
                }
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        {
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "P68373",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P68373"
                        }
                    ]
                }
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        },
        {
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "P70425",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P70425"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
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                        {
                            "id": "P70425",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P70425"
                        }
                    ]
                }
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        {
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "P70426",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P70426"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
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                        {
                            "id": "P70426",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P70426"
                        }
                    ]
                }
            ]
        },
        {
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                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "P81795",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P81795"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P81795",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P81795"
                        }
                    ]
                }
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "P84077",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P84077"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P84077",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P84077"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "P84078",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "P84078",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P84078"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P84078",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P84078"
                        }
                    ]
                }
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        {
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "P84079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P84079"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "P84079",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P84079"
                        }
                    ]
                }
            ]
        },
        {
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "P97538",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97538"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
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                        {
                            "id": "P97538",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97538"
                        }
                    ]
                }
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        {
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                {
                    "ec_number": "3.6.1.5",
                    "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.",
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                        {
                            "id": "P97687",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97687"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.1.5",
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                    "evidence": [
                        {
                            "id": "P97687",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/P97687"
                        }
                    ]
                }
            ]
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        {
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q00246",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q00246"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "Q00246",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q00246"
                        }
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                }
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        {
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q00582",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q00582"
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                    ]
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                {
                    "ec_number": "3.6.1.-",
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                        {
                            "id": "Q01514",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q01514"
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                    ]
                },
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q01514",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q01514"
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                {
                    "ec_number": "2.7.12.2",
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                            "id": "Q02750",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q02750"
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                    ]
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                {
                    "ec_number": "2.7.12.2",
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                        {
                            "id": "Q02750",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q02750"
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                {
                    "ec_number": "2.7.10.1",
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                        {
                            "id": "Q02763",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q02763"
                        }
                    ]
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                {
                    "ec_number": "2.7.10.1",
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                        {
                            "id": "Q02763",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q02763"
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "Q04970",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q04970"
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                    ]
                },
                {
                    "ec_number": "3.6.5.2",
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                        {
                            "id": "Q04970",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q04970"
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        {
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                {
                    "ec_number": "3.6.5.5",
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                            "id": "Q05193",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05193"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
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                        {
                            "id": "Q05193",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05193"
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            ]
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                {
                    "ec_number": "2.7.10.2",
                    "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
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                        {
                            "id": "Q05397",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05397"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.10.2",
                    "activity": "",
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                        {
                            "id": "Q05397",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05397"
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                    ]
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                {
                    "ec_number": "2.7.11.13",
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                        {
                            "id": "Q05513",
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                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.13",
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                        {
                            "id": "Q05513",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q05513"
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                    "ec_number": "3.6.5.3",
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                        {
                            "id": "Q05D44",
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                {
                    "ec_number": "3.6.5.3",
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                        {
                            "id": "Q05D44",
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                            "url": "https://www.uniprot.org/uniprot/Q05D44"
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                {
                    "ec_number": "3.1.3.48",
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                        {
                            "id": "Q06124",
                            "database": "UniProtKB",
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                    ]
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                {
                    "ec_number": "3.1.3.48",
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                        {
                            "id": "Q06124",
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                {
                    "ec_number": "3.6.5.5",
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                        {
                            "id": "Q08877",
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                            "url": "https://www.uniprot.org/uniprot/Q08877"
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                    ]
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                {
                    "ec_number": "3.6.5.5",
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                            "id": "Q08877",
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                    "ec_number": "3.6.5.2",
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                            "id": "Q08AT1",
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                {
                    "ec_number": "3.6.5.2",
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                            "id": "Q08AT1",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "Q0GUM3",
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                {
                    "ec_number": "2.7.11.1",
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                            "id": "Q13153",
                            "database": "UniProtKB",
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                {
                    "ec_number": "2.7.11.1",
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                            "id": "Q13153",
                            "database": "UniProtKB",
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        {
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                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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                            "id": "Q13177",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13177"
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                    ]
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                {
                    "ec_number": "2.7.11.1",
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                            "id": "Q13177",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13177"
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        {
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                {
                    "ec_number": "2.7.11.17",
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                            "id": "Q13554",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13554"
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                    ]
                },
                {
                    "ec_number": "2.7.11.17",
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                            "id": "Q13554",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13554"
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        {
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                {
                    "ec_number": "2.7.11.17",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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                        {
                            "id": "Q13555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13555"
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                    ]
                },
                {
                    "ec_number": "2.7.11.17",
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                            "id": "Q13555",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13555"
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        {
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                {
                    "ec_number": "2.7.11.17",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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                            "id": "Q13557",
                            "database": "UniProtKB",
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                    ]
                },
                {
                    "ec_number": "2.7.11.17",
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                            "id": "Q13557",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q13557"
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                    ]
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            ]
        },
        {
            "uniprot_ac": "Q149F3",
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                {
                    "ec_number": "3.6.5.-",
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                            "id": "Q149F3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q149F3"
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                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q15382",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q15382",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q15382"
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                    ]
                }
            ]
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        {
            "uniprot_ac": "Q15907",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q15907",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q15907"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
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                        {
                            "id": "Q15907",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q15907"
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                    ]
                }
            ]
        },
        {
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                {
                    "ec_number": "2.7.10.1",
                    "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
                    "evidence": [
                        {
                            "id": "Q16288",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q16288"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.10.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q16288",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q16288"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q16584",
            "gene_name": "MAP3K11",
            "activity": [
                {
                    "ec_number": "2.7.11.25",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q16584",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q16584"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.25",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q16584",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q16584"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q16620",
            "gene_name": "NTRK2",
            "activity": [
                {
                    "ec_number": "2.7.10.1",
                    "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
                    "evidence": [
                        {
                            "id": "Q16620",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q16620"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.10.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q16620",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q16620"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q24208",
            "gene_name": "eIF2gamma",
            "activity": [
                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q24208",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q24208"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q24208",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q24208"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q2TA68",
            "gene_name": "Opa1",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q2TA68",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q2TA68"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q2TA68",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q2TA68"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q2VIR3",
            "gene_name": "EIF2S3B",
            "activity": [
                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q2VIR3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q2VIR3"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q2VIR3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q2VIR3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3T9E4",
            "gene_name": "Tgtp2",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3T9E4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3T9E4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3TCT4",
            "gene_name": "Entpd7",
            "activity": [
                {
                    "ec_number": "3.6.1.15",
                    "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q3TCT4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3TCT4"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.1.15",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3TCT4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3TCT4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q3UX10",
            "gene_name": "Tubal3",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q3UX10",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q3UX10"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q4V339",
            "gene_name": "ZNG1F",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q4V339",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q4V339"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q53H12",
            "gene_name": "AGK",
            "activity": [
                {
                    "ec_number": "2.7.1.107",
                    "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).",
                    "evidence": [
                        {
                            "id": "Q53H12",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q53H12"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.94",
                    "activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.",
                    "evidence": [
                        {
                            "id": "Q53H12",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q53H12"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.138",
                    "activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).",
                    "evidence": [
                        {
                            "id": "Q53H12",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q53H12"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.107",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q53H12",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q53H12"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.138",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q53H12",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q53H12"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.1.94",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q53H12",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q53H12"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q54MH8",
            "gene_name": "dlpB",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q54MH8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54MH8"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q54MH8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54MH8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q54XD8",
            "gene_name": "eif2s3",
            "activity": [
                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q54XD8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54XD8"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q54XD8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54XD8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q54XP6",
            "gene_name": "eif5b",
            "activity": [
                {
                    "ec_number": "3.6.5.3",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q54XP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54XP6"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.3",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q54XP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54XP6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q54Y30",
            "gene_name": "rsmC",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q54Y30",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54Y30"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q54Y30",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q54Y30"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55AX0",
            "gene_name": "dlpC",
            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55AX0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55AX0"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55AX0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55AX0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55BW0",
            "gene_name": "rapC",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55BW0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55BW0"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55BW0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55BW0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CA9",
            "gene_name": "rasZ",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CA9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CA9"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CA9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CA9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CB0",
            "gene_name": "rasU",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CB0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB0"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CB0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CB7",
            "gene_name": "rasY",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CB7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB7"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CB7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CB8",
            "gene_name": "rasX",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CB8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB8"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CB8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CB9",
            "gene_name": "rasV",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CB9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB9"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CB9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CB9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55CC0",
            "gene_name": "rasW",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55CC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CC0"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55CC0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55CC0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q55F94",
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            "activity": [
                {
                    "ec_number": "3.6.5.5",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q55F94",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55F94"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.5",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q55F94",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q55F94"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5BJP6",
            "gene_name": "Gfm2",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5BJP6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5BJP6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5BJQ5",
            "gene_name": "Rit2",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q5BJQ5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5BJQ5"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5BJQ5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5BJQ5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5JTY5",
            "gene_name": "ZNG1C",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5JTY5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5JTY5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5RIA9",
            "gene_name": "ZNG1E",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5RIA9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5RIA9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5S006",
            "gene_name": "Lrrk2",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q5S006",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5S006"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5S006",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5S006"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5S006",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5S006"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5S007",
            "gene_name": "LRRK2",
            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q5S007",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5S007"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5S007",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5S007"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5S007",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5S007"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5SSG5",
            "gene_name": "Rasl10b",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q5SSG5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5SSG5"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5SSG5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5SSG5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5VST6",
            "gene_name": "ABHD17B",
            "activity": [
                {
                    "ec_number": "3.1.2.22",
                    "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].",
                    "evidence": [
                        {
                            "id": "Q5VST6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5VST6"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.2.22",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5VST6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5VST6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5VZM2",
            "gene_name": "RRAGB",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5VZM2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5VZM2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5XG87",
            "gene_name": "TENT4A",
            "activity": [
                {
                    "ec_number": "2.7.7.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5XG87",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XG87"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.7.19",
                    "activity": "ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide.",
                    "evidence": [
                        {
                            "id": "Q5XG87",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XG87"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q5XIF6",
            "gene_name": "Tuba4a",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q5XIF6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q5XIF6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q60766",
            "gene_name": "Irgm1",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q60766",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q60766"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q61107",
            "gene_name": "Gbp3",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q61107",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q61107"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q61411",
            "gene_name": "Hras",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q61411",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q61411"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q61411",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q61411"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q61820",
            "gene_name": "Rasl2-9",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q61820",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q61820"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q62293",
            "gene_name": "Tgtp1",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q62293",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62293"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q62636",
            "gene_name": "Rap1b",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q62636",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62636"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q62636",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62636"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q62639",
            "gene_name": "Rheb",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q62639",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q62639"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63486",
            "gene_name": "Rraga",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63486",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63486"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63487",
            "gene_name": "RragB",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63487",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63487"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q63663",
            "gene_name": "Gbp2",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q63663",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q63663"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q66HA6",
            "gene_name": "Arl8b",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q66HA6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q66HA6"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q66HA6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q66HA6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q68FR8",
            "gene_name": "Tuba3a",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q68FR8",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q68FR8"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q69ZS7",
            "gene_name": "Hbs1l",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q69ZS7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q69ZS7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AXM7",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AXM7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AXM7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AY56",
            "gene_name": "Tuba8",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AY56",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AY56"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AYB5",
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                {
                    "ec_number": "3.6.5.4",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q6AYB5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AYB5"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.4",
                    "activity": "",
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                        {
                            "id": "Q6AYB5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AYB5"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AYB5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AYB5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AYC2",
            "gene_name": "Irgm",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AYC2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AYC2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AYF9",
            "gene_name": "Irgc",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AYF9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AYF9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6AYZ1",
            "gene_name": "Tuba1c",
            "activity": [
                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6AYZ1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6AYZ1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6IMA3",
            "gene_name": "Rasl11a",
            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q6IMA3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6IMA3"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6IMA3",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6IMA3"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6IMA7",
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            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q6IMA7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6IMA7"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6IMA7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6IMA7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6IMB1",
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            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q6IMB1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6IMB1"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6IMB1",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6IMB1"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6NTA4",
            "gene_name": "Rragb",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6NTA4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6NTA4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6NXR0",
            "gene_name": "IRGC",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6NXR0",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6NXR0"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6NYB7",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q6NYB7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6NYB7"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6NYB7",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6NYB7"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6P9V9",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6P9V9",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6P9V9"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PCB6",
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                {
                    "ec_number": "3.1.2.22",
                    "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].",
                    "evidence": [
                        {
                            "id": "Q6PCB6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PCB6"
                        }
                    ]
                },
                {
                    "ec_number": "3.1.2.22",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PCB6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PCB6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6PEY2",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6PEY2",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6PEY2"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6RUV5",
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            "activity": [
                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q6RUV5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6RUV5"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6RUV5",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6RUV5"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6T310",
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                {
                    "ec_number": "3.6.5.2",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
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                        {
                            "id": "Q6T310",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6T310"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.2",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6T310",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6T310"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6VAB6",
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            "activity": [
                {
                    "ec_number": "2.7.11.1",
                    "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
                    "evidence": [
                        {
                            "id": "Q6VAB6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6VAB6"
                        }
                    ]
                },
                {
                    "ec_number": "2.7.11.1",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6VAB6",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6VAB6"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZMT4",
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            "activity": [
                {
                    "ec_number": "1.14.11.65",
                    "activity": "2 2-oxoglutarate + N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + L-lysyl(9)-[histone H3] + 2 succinate.",
                    "evidence": [
                        {
                            "id": "Q6ZMT4",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZMT4"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q6ZN66",
            "gene_name": "GBP6",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q6ZN66",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q6ZN66"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q71U36",
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                {
                    "ec_number": "3.6.5.-",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q71U36",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q71U36"
                        }
                    ]
                }
            ]
        },
        {
            "uniprot_ac": "Q75K18",
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                {
                    "ec_number": "3.6.5.4",
                    "activity": "GTP + H2O = GDP + H(+) + phosphate.",
                    "evidence": [
                        {
                            "id": "Q75K18",
                            "database": "UniProtKB",
                            "url": "https://www.uniprot.org/uniprot/Q75K18"
                        }
                    ]
                },
                {
                    "ec_number": "3.6.5.4",
                    "activity": "",
                    "evidence": [
                        {
                            "id": "Q75K18",
                            "database": "UniProtKB",
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                {
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                    "ec_number": "3.6.5.-",
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                    "ec_number": "3.6.5.-",
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                    "ec_number": "3.6.1.15",
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                {
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                {
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                {
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