{ "uniprot_canonical_ac": "P01008-1", "uniprot_ac": "P01008", "uniprot_id": "ANT3_HUMAN", "mass": { "chemical_mass": 52602.0, "monoisotopic_mass": 52602.0 }, "refseq": { "ac": "NP_000479", "name": "antithrombin-III isoform 1 precursor", "summary": "The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" }, "gene_names": [ { "name": "SERPINC1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P01008", "id": "P01008" }, { "name": "AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; THPH7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479", "id": "NP_000479" }, { "name": "AT3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P01008", "id": "P01008" }, { "name": "PRO0309", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P01008", "id": "P01008" }, { "name": "SERPINC1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479", "id": "NP_000479" } ], "protein_names": [ { "name": "Antithrombin-III", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P01008" }, { "name": "ATIII", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01008" }, { "name": "Serpin C1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P01008" }, { "name": "antithrombin-III isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479", "id": "NP_000479" }, { "name": "serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; antithrombin-III; serpin peptidase inhibitor clade C member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479", "id": "NP_000479" } ], "function": [ { "annotation": "Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype.", "evidence": [ { "database": "RefSeq", "id": "NP_000479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" }, { "database": "PubMed", "id": "37201530", "url": "https://glygen.org/publication/PubMed/37201530" } ] }, { "annotation": "Antithrombin Deficiency: Frequency in Patients with Thrombosis and Thrombophilic Families.", "evidence": [ { "database": "RefSeq", "id": "NP_000479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" }, { "database": "PubMed", "id": "37384805", "url": "https://glygen.org/publication/PubMed/37384805" } ] }, { "annotation": "Molecular analysis may be the best method to identify antithrombin deficiency. Up to 80% of patients with antithrombin deficiency have SERPINC1 gene defects, mostly (90% of the 315 gene defects described so far) point mutations or small deletions or insertions affecting the 7 exons or flanking regions. [review] Review article", "evidence": [ { "database": "RefSeq", "id": "NP_000479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" }, { "database": "PubMed", "id": "30005274", "url": "https://glygen.org/publication/PubMed/30005274" } ] }, { "annotation": "Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade (PubMed:15853774, PubMed:15140129). AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa (PubMed:15140129). Its inhibitory activity is greatly enhanced in the presence of heparin.", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008#function" }, { "database": "PubMed", "id": "15140129", "url": "https://glygen.org/publication/PubMed/15140129" }, { "database": "PubMed", "id": "15853774", "url": "https://glygen.org/publication/PubMed/15853774" } ] }, { "annotation": "Studies indicate that antithrombin III (ATIII) and its gene SerpinC1 may be related to many diseases, including hypertension and kidney diseases. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_000479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" }, { "database": "PubMed", "id": "28424376", "url": "https://glygen.org/publication/PubMed/28424376" } ] }, { "annotation": "The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020].", "evidence": [ { "database": "RefSeq", "id": "NP_000479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" } ] }, { "annotation": "Understanding the andromeda strain - The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_000479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000479" }, { "database": "PubMed", "id": "32829961", "url": "https://glygen.org/publication/PubMed/32829961" } ] } ], "disease": [ { "disease_id": "DOID:3755", "recommended_name": { "id": "DOID:3755", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3755", "name": "antithrombin III deficiency", "description": "A thrombophilia that is characterized by the tendency to form clots in the veins." }, "synonyms": [ { "id": "DOID:3755", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3755", "name": "AT III deficiency", "description": "" }, { "id": "DOID:3755", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3755", "name": "hereditary thrombophilia due to congenital antithrombin deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "hereditary antithrombin deficiency", "description": "A rare, genetic, hematological disease characterized by decreased levels of antithrombin activity in plasma resulting in impaired inactivation of thrombin and factor Xa. Patients have an increased risk for venous thromboembolism, usually in the deep veins of the arms, legs and pulmonary system and, on occasion, in other venous territories (e.g. cerebral veins or sinus, mesenteric, portal, hepatic, renal and/or retinal veins)." }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "AT III deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "AT3D", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "antithrombin 3 deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "antithrombin III deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": 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"https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757851817" }, { "id": "rs757851817", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757851817" }, { "id": "rs757851817", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757851817" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 105, "end_pos": 105, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDN->NDS).", "chr_id": "1", "chr_pos": "173914647", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N105", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1657909645", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1657909645" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 114, "end_pos": 114, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation 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Patients have an increased risk for venous thromboembolism, usually in the deep veins of the arms, legs and pulmonary system and, on occasion, in other venous territories (e.g. cerebral veins or sinus, mesenteric, portal, hepatic, renal and/or retinal veins)." }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "AT III deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "AT3D", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "antithrombin 3 deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "antithrombin III deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": 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Patients have an increased risk for venous thromboembolism, usually in the deep veins of the arms, legs and pulmonary system and, on occasion, in other venous territories (e.g. cerebral veins or sinus, mesenteric, portal, hepatic, renal and/or retinal veins)." }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "AT III deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "AT3D", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "antithrombin 3 deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013144", "name": "antithrombin III deficiency", "description": "" }, { "id": "MONDO:0013144", "resource": "MONDO", "url": 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"database": "BioXpress", "id": "P01008", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01008" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P01008", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01008" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P01008" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MYSNVIGTVTSGKRKVYLLSLLLIGFWDCVTCHGSPVDICTAKPRDIPMNPMCIYRSPEKKATEDEGSEQKIPEATNRRVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINELTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPCVK", "length": 464, "header": "sp|P01008-1|ANT3_HUMAN Isoform 1 of Antithrombin-III OS=Homo sapiens OX=9606 GN=SERPINC1 PE=1 SV=1 CANONICAL=P01008-1" }, "locus": { "chromosome": "1", "start_pos": 173917259, "end_pos": 173903892, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000367698.4", "url": "https://www.ensembl.org/id/ENST00000367698.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000356671.3", "url": "https://www.ensembl.org/id/ENSP00000356671.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G00912UN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "P01008", "database": "UniCarbKB", "url": "" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "P01008@N128", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01008@N128" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" } ] }, { "glytoucan_ac": "G10486CT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "P01008@N128", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01008@N128" } ] }, { "glytoucan_ac": "G11911BT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G15169WU", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G22310AV", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G37868ZX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" } ] }, { "glytoucan_ac": "G42358LZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "P01008", "database": "UniCarbKB", "url": "" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" } ] }, { "glytoucan_ac": "G47518TP", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" }, { "id": "34725484", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725484" } ] }, { "glytoucan_ac": "G48414YA", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "24530628", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24530628" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" }, { "id": "30237853", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30237853" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" }, { "id": "34725484", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725484" } ] }, { "glytoucan_ac": "G59626AS", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "P01008@N128", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01008@N128" } ] }, { "glytoucan_ac": "G75983OB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" }, { "id": "30237853", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30237853" } ] }, { "glytoucan_ac": "G82830MN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" }, { "id": "30237853", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30237853" } ] }, { "glytoucan_ac": "G88374WZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "P01008@N128", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01008@N128" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 128, "start_aa": "Asn", "end_pos": 128, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn128", "evidence": [ { "id": "P01008", "database": "UniCarbKB", "url": "" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "P01008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01008#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19159218" }, { "id": "14760718", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14760718" }, { "id": "16335952", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16335952" }, { "id": "1DZG", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1DZG" }, { "id": "1DZH", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1DZH" }, { "id": "1E03", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1E03" }, { "id": "1E04", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1E04" }, { "id": "1E05", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1E05" }, { "id": "1NQ9", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1NQ9" }, { "id": "1OYH", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1OYH" }, { "id": "1T1F", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1T1F" }, { "id": "1TB6", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/1TB6" }, { "id": "2B5T", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/2B5T" }, { "id": "2BEH", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/2BEH" }, { "id": "2HIJ", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/2HIJ" }, { "id": "2ZNH", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/2ZNH" }, { "id": "3EVJ", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3EVJ" }, { "id": "3KCG", "database": "RCSB PDB", "url": "https://www.rcsb.org/sequence/3KCG" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", 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"relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "P01008", "database": "UniCarbKB", "url": "" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "P01008@N187", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01008@N187" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G10486CT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "P01008@N187", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P01008@N187" } ] }, { "glytoucan_ac": "G11911BT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G13694XX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "766", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/766" }, { "id": "29391424", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29391424" } ] }, { "glytoucan_ac": "G22140GZ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 187, "start_aa": "Asn", "end_pos": 187, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn187", "evidence": [ { "id": "P01008", "database": "UniCarbKB", "url": "" }, { "id": "19838169", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19838169" }, 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"https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "serine-type endopeptidase inhibitor activity", "id": "GO:0004867", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004867", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "heparin binding", "id": "GO:0008201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "endoplasmic reticulum lumen", "id": "GO:0005788", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "blood microparticle", "id": "GO:0072562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072562", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "collagen-containing extracellular matrix", "id": "GO:0062023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "blood coagulation", "id": "GO:0007596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007596", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" }, { "name": "regulation of blood coagulation", "id": "GO:0030193", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030193", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "antithrombin-III N-glycosylated 1 (human)", "definition": "An antithrombin-III (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P01008-1, Asn-128, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051366", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051366" } ] }, { "name": "antithrombin-III N-glycosylated 2 (human)", "definition": "An antithrombin-III (human) that has been N-glycosylated at the residue equivalent to Asn-128 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:P01008-1, Asn-128, MOD:00160~GNO:G42358LZ. [PRO:DNx, PMID:24279413]", "evidence": [ { "id": "PR:000051367", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051367" } ] }, { "name": "antithrombin-III N-glycosylated 3 (human)", "definition": "An antithrombin-III (human) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P01008-1, Asn-187, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051368", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051368" } ] }, { "name": "antithrombin-III N-glycosylated 4 (human)", "definition": "An antithrombin-III (human) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P01008-1, Asn-187, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:19838169]", "evidence": [ { "id": "PR:000051369", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051369" } ] }, { "name": "antithrombin-III N-glycosylated 5 (human)", "definition": "An antithrombin-III (human) that has been N-glycosylated at the residue equivalent to Asn-187 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P01008-1, Asn-187, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051370", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051370" } ] }, { "name": "antithrombin-III N-glycosylated 6 (human)", "definition": "An antithrombin-III (human) that has been N-glycosylated at the residue equivalent to Asn-224 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P01008-1, Asn-224, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051371", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051371" } ] }, { "name": "antithrombin-III O-glycosylated 1 (human)", "definition": "An antithrombin-III (human) that has been O-glycosylated at the residue equivalent to Thr-418 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P01008-1, Thr-418, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000051372", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051372" } ] }, { "name": "antithrombin-III O-glycosylated 2 (human)", "definition": "An antithrombin-III (human) that has been O-glycosylated at the residue equivalent to Thr-418 of the amino acid sequence represented by UniProtKB:P01008-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P01008-1, Thr-418, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000051373", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051373" } ] } ], "site_annotation": [ { "start_pos": 128, "end_pos": 130, "annotation": "n_glycosylation_sequon" }, { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by FAM20C in the extracellular medium.", "evidence": [ { "database": "UniProtKB", "id": "P01008", "url": "https://www.uniprot.org/uniprot/P01008" }, { "database": "PubMed", "id": "26091039", "url": "https://glygen.org/publication/PubMed/26091039" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [ { "assessed_biomarker_entity": "Antithrombin (SERPINC1)", "biomarker_id": "A0069", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32172226", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32172226" }, { "id": "32829961", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32829961" }, { "id": "19227008", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19227008" } ], "instances": [ { "best_biomarker_type": "prognostic", "status": "decreased SERPINC1 level", "disease": { "disease_id": "DOID:0080600", "recommended_name": { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID-19", "description": "A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2." }, "synonyms": [ { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019 Novel Coronavirus (2019-nCoV)", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "2019-nCoV infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan coronavirus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "Wuhan seafood market pneumonia virus infection", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "COVID19", "description": "" }, { "id": "DOID:0080600", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080600", "name": "SARS-CoV-2 infection", "description": "" } ] }, "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "32172226", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32172226" }, { "id": "32829961", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32829961" } ] }, { "best_biomarker_type": "prognostic", "status": "increased SERPINC1 level", "disease": { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "19227008", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19227008" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 128, 167, 176, 187, 224, 460 ], "o_linked_sites": [ 418 ], "snv_sites": [ 6, 39, 79, 105, 114, 130, 167, 169, 221, 224, 251, 418, 439, 452 ], "glycation_sites": [], "phosphorylation_sites": [ 63, 68, 174 ], "sequon_annotation_sites": [ { "start_pos": 128, "end_pos": 130 }, { "start_pos": 167, "end_pos": 169 }, { "start_pos": 187, "end_pos": 189 }, { "start_pos": 224, "end_pos": 226 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 46 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_glycans", "count": 25 }, { "field": "n_linked_glycan_sites", "count": 9 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 5 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 41 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 25 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 19 }, { "field": "total_sites", "count": 14 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 245 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }