{ "uniprot_canonical_ac": "P00738-1", "uniprot_ac": "P00738", "uniprot_id": "HPT_HUMAN", "mass": { "chemical_mass": 45205.0, "monoisotopic_mass": 45205.0 }, "refseq": { "ac": "NP_001119574", "name": "haptoglobin isoform 2 preproprotein", "summary": "This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" }, "gene_names": [ { "name": "HP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P00738", "id": "P00738" }, { "name": "BP; HP2ALPHA2; HPA1S", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574", "id": "NP_001119574" }, { "name": "HP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574", "id": "NP_001119574" } ], "protein_names": [ { "name": "Haptoglobin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P00738" }, { "name": "Zonulin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00738" }, { "name": "haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; binding peptide; zonulin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574", "id": "NP_001119574" }, { "name": "haptoglobin isoform 2 preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574", "id": "NP_001119574" } ], "function": [ { "annotation": "Antimicrobial protein, zonulin, has antibacterial activity and functions in regulation of intestinal barrier function. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" }, { "database": "PubMed", "id": "21248165", "url": "https://glygen.org/publication/PubMed/21248165" } ] }, { "annotation": "As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738#function" }, { "database": "PubMed", "id": "21248165", "url": "https://glygen.org/publication/PubMed/21248165" } ] }, { "annotation": "Assessment of selected muscle damage markers and zonulin concentration after maximum-intensity exercise in men with type 1 diabetes treated with a personal insulin pump.", "evidence": [ { "database": "RefSeq", "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" }, { "database": "PubMed", "id": "37481476", "url": "https://glygen.org/publication/PubMed/37481476" } ] }, { "annotation": "Disease-Specific haptoglobin N-Glycosylation in inflammatory disorders between cancers and benign diseases of 3 types of female internal genital organs.", "evidence": [ { "database": "RefSeq", "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" }, { "database": "PubMed", "id": "37285951", "url": "https://glygen.org/publication/PubMed/37285951" } ] }, { "annotation": "Role of haptoglobin 2-2 genotype on disease progression and mortality among South Indian chronic kidney disease patients.", "evidence": [ { "database": "RefSeq", "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" }, { "database": "PubMed", "id": "37522948", "url": "https://glygen.org/publication/PubMed/37522948" } ] }, { "annotation": "The Haptoglobin Response after Aneurysmal Subarachnoid Haemorrhage. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" }, { "database": "PubMed", "id": "38069244", "url": "https://glygen.org/publication/PubMed/38069244" } ] }, { "annotation": "The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738#function" }, { "database": "PubMed", "id": "21248165", "url": "https://glygen.org/publication/PubMed/21248165" } ] }, { "annotation": "This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014].", "evidence": [ { "database": "RefSeq", "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574" } ] } ], "disease": [ { "disease_id": "MONDO:0013564", "recommended_name": { "id": "MONDO:0013564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013564", "name": "anhaptoglobinemia", "description": "" }, "synonyms": [ { "id": "MONDO:0013564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013564", "name": "anhaptoglobinemia", "description": "" }, { "id": "MONDO:0013564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013564", "name": "hypohaptoglobinemia", "description": "" }, { "id": "MONDO:0013564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013564", "name": "AHP", "description": "" }, { "id": "MONDO:0013564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013564", "name": "ANHAPTOGLOBINEMIA", "description": "" }, { "id": "MONDO:0013564", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013564", "name": "Ahaptoglobinemia", "description": "" }, { "id": "MIM:614081", "resource": "MIM", "url": "https://www.omim.org/entry/614081", "name": "Anhaptoglobinemia", "description": "Anhaptoglobinemia" } ], "evidence": [ { "id": "614081", "database": "MIM", "url": "https://www.omim.org/entry/614081" } ] } ], "snv": [ { "evidence": [ { "id": "rs587660", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587660" }, { "id": "rs587660", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs587660" }, { "id": "rs587660", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs587660#frequency_tab" }, { "id": "rs587660", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs587660" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 243, "end_pos": 243, "sequence_org": "S", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYS->NYP); o-glyco-site-loss (S->P).", "chr_id": "16", "chr_pos": "72060396", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S243", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs761939978", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761939978" }, { "id": "rs761939978", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761939978" }, { "id": "rs761939978", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs761939978#frequency_tab" }, { "id": "rs761939978", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs761939978" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 243, "end_pos": 243, "sequence_org": "S", "sequence_mut": "Y", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYS->NYY); o-glyco-site-loss (S->Y).", "chr_id": "16", "chr_pos": "72060397", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S243", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs375137689", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs375137689" }, { "id": "rs375137689", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs375137689" }, { "id": "rs375137689", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs375137689#frequency_tab" }, { "id": "rs375137689", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs375137689" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 184, "end_pos": 184, "sequence_org": "N", "sequence_mut": "Y", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->YLT).", "chr_id": "16", "chr_pos": "72060219", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N184", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs766356379", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766356379" }, { "id": "rs766356379", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766356379" }, { "id": "rs766356379", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs766356379" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 187, "end_pos": 187, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "16", "chr_pos": "72060228", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T187", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1277810195", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1277810195" }, { "id": "rs1277810195", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1277810195#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 205, "end_pos": 205, "sequence_org": "F", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLF->NLS).", "chr_id": "16", "chr_pos": "72060283", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "F205", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs761396788", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761396788" }, { "id": "rs761396788", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761396788" }, { "id": "rs761396788", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs761396788" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 207, "end_pos": 207, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NHS->SHS).", "chr_id": "16", "chr_pos": "72060289", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N207", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1189485596", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1189485596" }, { "id": "rs1189485596", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1189485596" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 211, "end_pos": 211, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAT->KAT).", "chr_id": "16", "chr_pos": "72060302", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N211", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760529864", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760529864" }, { "id": "rs760529864", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760529864" }, { "id": "rs760529864", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760529864" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 213, "end_pos": 213, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAT->NAI).", "chr_id": "16", "chr_pos": "72060307", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T213", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760529864", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760529864" }, { "id": "rs760529864", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760529864" }, { "id": "rs760529864", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760529864" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 213, "end_pos": 213, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAT->NAK).", "chr_id": "16", "chr_pos": "72060307", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T213", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs750845655", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750845655" }, { "id": "rs750845655", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750845655" }, { "id": "rs750845655", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs750845655#frequency_tab" }, { "id": "rs750845655", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs750845655" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 220, "end_pos": 220, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TLT->NLT).", "chr_id": "16", "chr_pos": "72060328", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T220", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs747674381", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747674381" }, { "id": "rs747674381", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747674381" }, { "id": "rs747674381", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs747674381" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 255, "end_pos": 255, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KVS->NVS).", "chr_id": "16", "chr_pos": "72060434", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K255", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs776293041", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776293041" }, { "id": "rs776293041", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776293041" }, { "id": "rs776293041", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs776293041" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 261, "end_pos": 261, "sequence_org": "R", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NER->NET).", "chr_id": "16", "chr_pos": "72060451", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R261", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs745716802", "database": "dbSNP", "url": 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"Glycoproteomics" ] }, { "id": "PR:000051123", "url": "https://proconsortium.org/app/entry/PR:000051123", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051124", "url": "https://proconsortium.org/app/entry/PR:000051124", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051125", "url": "https://proconsortium.org/app/entry/PR:000051125", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051126", "url": "https://proconsortium.org/app/entry/PR:000051126", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051127", "url": "https://proconsortium.org/app/entry/PR:000051127", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051128", "url": "https://proconsortium.org/app/entry/PR:000051128", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051129", "url": "https://proconsortium.org/app/entry/PR:000051129", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051130", "url": "https://proconsortium.org/app/entry/PR:000051130", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051131", "url": "https://proconsortium.org/app/entry/PR:000051131", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051132", "url": "https://proconsortium.org/app/entry/PR:000051132", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051133", "url": "https://proconsortium.org/app/entry/PR:000051133", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051134", "url": "https://proconsortium.org/app/entry/PR:000051134", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051135", "url": "https://proconsortium.org/app/entry/PR:000051135", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051136", "url": "https://proconsortium.org/app/entry/PR:000051136", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051137", "url": "https://proconsortium.org/app/entry/PR:000051137", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051138", "url": "https://proconsortium.org/app/entry/PR:000051138", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051139", "url": "https://proconsortium.org/app/entry/PR:000051139", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051140", "url": "https://proconsortium.org/app/entry/PR:000051140", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051141", "url": "https://proconsortium.org/app/entry/PR:000051141", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051142", "url": "https://proconsortium.org/app/entry/PR:000051142", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051143", "url": "https://proconsortium.org/app/entry/PR:000051143", "database": "PRO", "categories": [ 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"Glycoproteomics" ] }, { "id": "PR:000051151", "url": "https://proconsortium.org/app/entry/PR:000051151", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051152", "url": "https://proconsortium.org/app/entry/PR:000051152", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051153", "url": "https://proconsortium.org/app/entry/PR:000051153", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051154", "url": "https://proconsortium.org/app/entry/PR:000051154", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051155", "url": "https://proconsortium.org/app/entry/PR:000051155", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051156", "url": "https://proconsortium.org/app/entry/PR:000051156", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051157", "url": "https://proconsortium.org/app/entry/PR:000051157", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051158", "url": "https://proconsortium.org/app/entry/PR:000051158", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051159", "url": "https://proconsortium.org/app/entry/PR:000051159", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR:000051160", "url": "https://proconsortium.org/app/entry/PR:000051160", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_P00738", "url": "http://purl.obolibrary.org/obo/PR_P00738", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001119574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119574", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "P00738", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "A0A0C4DGL8", "url": "https://www.uniprot.org/uniprot/A0A0C4DGL8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0C4DGL8-1", "url": "https://www.uniprot.org/uniprot/A0A0C4DGL8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y300", "url": "https://www.uniprot.org/uniprot/H0Y300", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y300-1", "url": "https://www.uniprot.org/uniprot/H0Y300-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BMJ7", "url": "https://www.uniprot.org/uniprot/H3BMJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BMJ7-1", "url": "https://www.uniprot.org/uniprot/H3BMJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BS21", "url": "https://www.uniprot.org/uniprot/H3BS21", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BS21-1", "url": "https://www.uniprot.org/uniprot/H3BS21-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KRH2", "url": "https://www.uniprot.org/uniprot/J3KRH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KRH2-1", "url": "https://www.uniprot.org/uniprot/J3KRH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KSV1", "url": "https://www.uniprot.org/uniprot/J3KSV1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KSV1-1", "url": "https://www.uniprot.org/uniprot/J3KSV1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QLC9", "url": "https://www.uniprot.org/uniprot/J3QLC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QLC9-1", "url": "https://www.uniprot.org/uniprot/J3QLC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QQI8", "url": "https://www.uniprot.org/uniprot/J3QQI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QQI8-1", "url": "https://www.uniprot.org/uniprot/J3QQI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QR68", "url": "https://www.uniprot.org/uniprot/J3QR68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QR68-1", "url": "https://www.uniprot.org/uniprot/J3QR68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P00738-1", "url": "https://www.uniprot.org/uniprot/P00738-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "P00738-2", "url": "https://www.uniprot.org/uniprot/P00738-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 406, "header": "sp|P00738-1|HPT_HUMAN Isoform 1 of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "isoforms": [ { "isoform_ac": "A0A0C4DGL8-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 347, "header": "tr|A0A0C4DGL8-1|A0A0C4DGL8_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060887, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000565574.5", "url": "https://www.ensembl.org/id/ENST00000565574.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454966.1", "url": "https://www.ensembl.org/id/ENSP00000454966.1" } ] } }, { "isoform_ac": "H0Y300-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGEAMPCSLPHVNLRVTFTSPADVGKEGMLMMMSPSPRVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 442, "header": "tr|H0Y300-1|HPT_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=4 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060887, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000357763.8", "url": "https://www.ensembl.org/id/ENST00000357763.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000350406.5", "url": "https://www.ensembl.org/id/ENSP00000350406.5" } ] } }, { "isoform_ac": "H3BMJ7-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAAHTE", "length": 92, "header": "tr|H3BMJ7-1|H3BMJ7_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060673, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000562526.5", "url": "https://www.ensembl.org/id/ENST00000562526.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454413.1", "url": "https://www.ensembl.org/id/ENSP00000454413.1" } ] } }, { "isoform_ac": "H3BS21-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEK", "length": 222, "header": "tr|H3BS21-1|H3BS21_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060632, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000564499.5", "url": "https://www.ensembl.org/id/ENST00000564499.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000456503.1", "url": "https://www.ensembl.org/id/ENSP00000456503.1" } ] } }, { "isoform_ac": "J3KRH2-1", "url": "", "sequence": { "sequence": "XALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAGGC", "length": 149, "header": "tr|J3KRH2-1|J3KRH2_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72059198, "end_pos": 72056161, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000576168.6", "url": "https://www.ensembl.org/id/ENST00000576168.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000461999.1", "url": "https://www.ensembl.org/id/ENSP00000461999.1" } ] } }, { "isoform_ac": "J3KSV1-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEA", "length": 88, "header": "tr|J3KSV1-1|J3KSV1_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72059187, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000568417.6", "url": "https://www.ensembl.org/id/ENST00000568417.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000462662.1", "url": "https://www.ensembl.org/id/ENSP00000462662.1" } ] } }, { "isoform_ac": "J3QLC9-1", "url": "", "sequence": { "sequence": "XALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 365, "header": "tr|J3QLC9-1|HPT_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060889, "end_pos": 72056161, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000567612.2", "url": "https://www.ensembl.org/id/ENST00000567612.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000463491.1", "url": "https://www.ensembl.org/id/ENSP00000463491.1" } ] } }, { "isoform_ac": "J3QQI8-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAGGC", "length": 91, "header": "tr|J3QQI8-1|HPT_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72059196, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569639.5", "url": "https://www.ensembl.org/id/ENST00000569639.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000463755.1", "url": "https://www.ensembl.org/id/ENSP00000463755.1" } ] } }, { "isoform_ac": "J3QR68-1", "url": "", "sequence": { "sequence": "XALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 404, "header": "tr|J3QR68-1|HPT_HUMAN Computationally mapped isoform of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060889, "end_pos": 72056161, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000567185.7", "url": "https://www.ensembl.org/id/ENST00000567185.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000464070.1", "url": "https://www.ensembl.org/id/ENSP00000464070.1" } ] } }, { "isoform_ac": "P00738-1", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 406, "header": "sp|P00738-1|HPT_HUMAN Isoform 1 of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060887, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000355906.10", "url": "https://www.ensembl.org/id/ENST00000355906.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000348170.5", "url": "https://www.ensembl.org/id/ENSP00000348170.5" } ] } }, { "isoform_ac": "P00738-2", "url": "", "sequence": { "sequence": "MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN", "length": 347, "header": "sp|P00738-2|HPT_HUMAN Isoform 2 of Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 SV=1 CANONICAL=P00738-1" }, "locus": { "chromosome": "16", "start_pos": 72060887, "end_pos": 72054653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398131.6", "url": "https://www.ensembl.org/id/ENST00000398131.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000381199.2", "url": "https://www.ensembl.org/id/ENSP00000381199.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "automatic_literature_mining", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 135, "start_aa": "Asn", "end_pos": 135, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn135", "evidence": [ { "id": "19714880", "database": "Automatic Literature Mining", "url": "https://research.bioinformatics.udel.edu/glyco/pmid/19714880" }, { "id": "19714880", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19714880" } ] }, { "glytoucan_ac": "G00912UN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P00738", "database": "UniCarbKB", "url": "" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "24841998", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24841998" }, { "id": "P00738@N184", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00738@N184" } ] }, { "glytoucan_ac": "G02030ZB", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "744", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/744" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" } ] }, { "glytoucan_ac": "G03596YS", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P00738@N184", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00738@N184" } ] }, { "glytoucan_ac": "G04909DG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "744", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/744" }, { "id": "24103369", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24103369" } ] }, { "glytoucan_ac": "G05933EN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P00738@N184", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00738@N184" } ] }, { "glytoucan_ac": "G06247RL", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P00738", "database": "UniCarbKB", "url": "" }, { "id": "29671580", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29671580" }, { "id": "P00738@N184", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00738@N184" } ] }, { "glytoucan_ac": "G06356OH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "744", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/744" }, { "id": "24279413", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24279413" }, { "id": "24841998", "database": "PubMed", "url": 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"attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "P00738@N184", "database": "GPTwiki", "url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00738@N184" } ] }, { "glytoucan_ac": "G08146BT", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "744", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/744" }, { "id": "23829323", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23829323" }, { "id": "32125861", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32125861" } ] }, { "glytoucan_ac": "G08293MJ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", 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Receptor-mediated uptake with recycling of the protein.", "journal": "The Biochemical journal", "date": "1979", "authors": "Smith A, Morgan WT", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "496916", "url": "https://glygen.org/publication/PubMed/496916" } ] }, { "title": "Studies on the structures of haptoglobin 1-1 and hemoglobin in the haptoglobin-hemoglobin complex.", "journal": "Biochemical and biophysical research communications", "date": "1971", "authors": "Waks M, Kahn PC, Beychok S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "5135507", "url": "https://glygen.org/publication/PubMed/5135507" } ] }, { "title": "Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA.", "journal": "Nucleic Acids Res.", "date": "1983", "authors": "Raugei G, Bensi G, Colantuoni V, Romano V, Santoro C, Costanzo F, Cortese R", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6310515", "url": "https://glygen.org/publication/PubMed/6310515" } ] }, { "title": "Identification and characterization of human haptoglobin cDNA.", "journal": "Proc. 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U.S.A.", "date": "1983", "authors": "Yang F, Brune J L, Baldwin W D, Barnett D R, Bowman B H", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6310599", "url": "https://glygen.org/publication/PubMed/6310599" } ] }, { "title": "Duplication within the haptoglobin Hp2 gene.", "journal": "Nature", "date": "1984", "authors": "Maeda N, Yang F, Barnett D R, Bowman B H, Smithies O", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6325933", "url": "https://glygen.org/publication/PubMed/6325933" } ] }, { "title": "Evolution of haptoglobin: comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS.", "journal": "Nucleic acids research", "date": "1984", "authors": "Brune JL, Yang F, Barnett DR, Bowman BH", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6330675", "url": "https://glygen.org/publication/PubMed/6330675" } ] }, { "title": "Hemopexin-mediated heme uptake by liver. Characterization of the interaction of heme-hemopexin with isolated rabbit liver plasma membranes.", "journal": "The Journal of biological chemistry", "date": "1984", "authors": "Smith A, Morgan WT", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "6480598", "url": "https://glygen.org/publication/PubMed/6480598" } ] }, { "title": "Characterization of human haptoglobin cDNAs coding for alpha 2FS beta and alpha 1S beta variants.", "journal": "FEBS letters", "date": "1984", "authors": "van der Straten A, Herzog A, Cabezon T, Bollen A", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6546723", "url": "https://glygen.org/publication/PubMed/6546723" } ] }, { "title": "Molecular cloning of human haptoglobin cDNA: evidence for a single mRNA coding for alpha 2 and beta chains.", "journal": "EMBO J.", "date": "1983", "authors": "vander Straten A, Herzog A, Jacobs P, Cabez\u00f3n T, Bollen A", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6688992", "url": "https://glygen.org/publication/PubMed/6688992" } ] }, { "title": "Hemin binding to serum proteins and the catalysis of interprotein transfer.", "journal": "Biochemistry", "date": "1983", "authors": "Pasternack RF, Gibbs EJ, Hoeflin E, Kosar WP, Kubera G, Skowronek CA, Wong NM, Muller-Eberhard U", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "6849882", "url": "https://glygen.org/publication/PubMed/6849882" } ] }, { "title": "Covalent structure of human haptoglobin: a serine protease homolog.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1980", "authors": "Kurosky A, Barnett DR, Lee TH, Touchstone B, Hay RE, Arnott MS, Bowman BH, Fitch WM", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "reference": [ { "type": "PubMed", "id": "6997877", "url": "https://glygen.org/publication/PubMed/6997877" } ] }, { "title": "Haptoglobin-hemoglobin complex. Subunit interaction probed by cross-linking.", "journal": "The Journal of biological chemistry", "date": "1981", "authors": "Greer J, Liao WD, Brown WE", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "7263686", "url": "https://glygen.org/publication/PubMed/7263686" } ] }, { "title": "Hemopexin-mediated transport of heme into isolated rat hepatocytes.", "journal": "The Journal of biological chemistry", "date": "1981", "authors": "Smith A, Morgan WT", "evidence": [ { "database": "Reactome", "id": "R-HSA-2168880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2168880" } ], "reference": [ { "type": "PubMed", "id": "7287740", "url": "https://glygen.org/publication/PubMed/7287740" } ] }, { "title": "Haemoglobin binding with haptoglobin. 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9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN", "length": 348 }, "evidence": [ { "id": "45923428", "url": "http://www.informatics.jax.org/homology/45923428", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P06866-1", "protein_name": "Haptoglobin", "gene_name": "Hp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRALGAVVTLLLWGQLFAVELGNDATDIEDDSCPKPPEIANGYVEHLVRYRCRQFYKLQTEGDGIYTLNSEKQWVNPAAGDKLPKCEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAQNLFLNHSENATAKDIAPTLTLYVGKNQLVEIEKVVLHPERSVVDIGLIKLKQKVLVTEKVMPICLPSKDYVAPGRMGYVSGWGRNVNFRFTERLKYVMLPVADQEKCELHYEKSTVPEKKGAVSPVGVQPILNKHTFCAGLTKYEEDTCYGDAGSAFAVHDTEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN", "length": 347 }, "evidence": [ { "id": "45923428", "url": "http://www.informatics.jax.org/homology/45923428", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61646-1", "protein_name": "Haptoglobin", "gene_name": "Hp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRALGAVVTLLLWGQLFAVELGNDAMDFEDDSCPKPPEIANGYVEHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAVCGKPKHPVDQVQRIIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDITPTLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYIAPGRVGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSPVGVQPILNEHTFCAGLTKYQEDTCYGDAGSAFAIHDMEEDTWYAAGILSFDKSCAVAEYGVYVRATDLKDWVQETMAKN", "length": 347 }, "evidence": [ { "id": "45923428", "url": "http://www.informatics.jax.org/homology/45923428", "database": "MGI" }, { "id": "P00738", "url": "https://omabrowser.org/oma/group/P00738/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "antioxidant activity", "id": "GO:0016209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016209", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "hemoglobin binding", "id": "GO:0030492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030492", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "blood microparticle", "id": "GO:0072562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072562", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "specific granule lumen", "id": "GO:0035580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035580", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "tertiary granule lumen", "id": "GO:1904724", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904724", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "endocytic vesicle lumen", "id": "GO:0071682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071682", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "haptoglobin-hemoglobin complex", "id": "GO:0031838", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031838", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "acute-phase response", "id": "GO:0006953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006953", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "negative regulation of hydrogen peroxide catabolic process", "id": "GO:2000296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000296", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "defense response", "id": "GO:0006952", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006952", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "response to hydrogen peroxide", "id": "GO:0042542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042542", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "negative regulation of oxidoreductase activity", "id": "GO:0051354", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051354", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" }, { "name": "immune system process", "id": "GO:0002376", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376", "evidence": [ { "database": "UniProtKB", "id": "P00738", "url": "https://www.uniprot.org/uniprot/P00738" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "haptoglobin N-glycosylated 1 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051074", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051074" } ] }, { "name": "haptoglobin N-glycosylated 2 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051075", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051075" } ] }, { "name": "haptoglobin N-glycosylated 3 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G10486CT. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051076", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051076" } ] }, { "name": "haptoglobin N-glycosylated 4 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051077", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051077" } ] }, { "name": "haptoglobin N-glycosylated 5 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G27947YN. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051078", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051078" } ] }, { "name": "haptoglobin N-glycosylated 6 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G28003YJ. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G28003YJ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051079", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051079" } ] }, { "name": "haptoglobin N-glycosylated 7 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G30048DT. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G30048DT. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051080", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051080" } ] }, { "name": "haptoglobin N-glycosylated 8 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G31118FR. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G31118FR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051081", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051081" } ] }, { "name": "haptoglobin N-glycosylated 9 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G31153XO. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G31153XO. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051082", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051082" } ] }, { "name": "haptoglobin N-glycosylated 10 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G36131WL. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G36131WL. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051083", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051083" } ] }, { "name": "haptoglobin N-glycosylated 11 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G37868ZX. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G37868ZX. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051084", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051084" } ] }, { "name": "haptoglobin N-glycosylated 12 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G40926MX. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G40926MX. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051085", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051085" } ] }, { "name": "haptoglobin N-glycosylated 13 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G42358LZ. [PRO:DNx, PMID:18214858, PMID:24279413]", "evidence": [ { "id": "PR:000051086", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051086" } ] }, { "name": "haptoglobin N-glycosylated 14 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G58232MG. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G58232MG. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051087", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051087" } ] }, { "name": "haptoglobin N-glycosylated 15 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051088", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051088" } ] }, { "name": "haptoglobin N-glycosylated 16 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G72309KR. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G72309KR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051089", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051089" } ] }, { "name": "haptoglobin N-glycosylated 17 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G78019KD. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G78019KD. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051090", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051090" } ] }, { "name": "haptoglobin N-glycosylated 18 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G78644BR. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G78644BR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051091", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051091" } ] }, { "name": "haptoglobin N-glycosylated 19 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G81247ZO. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G81247ZO. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051092", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051092" } ] }, { "name": "haptoglobin N-glycosylated 20 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G83009TH. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G83009TH. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051093", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051093" } ] }, { "name": "haptoglobin N-glycosylated 21 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G83213GG. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G83213GG. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051094", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051094" } ] }, { "name": "haptoglobin N-glycosylated 22 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G85144OK. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G85144OK. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051095", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051095" } ] }, { "name": "haptoglobin N-glycosylated 23 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G87947EJ. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G87947EJ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051096", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051096" } ] }, { "name": "haptoglobin N-glycosylated 24 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051097", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051097" } ] }, { "name": "haptoglobin N-glycosylated 25 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G93999ON. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G93999ON. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051098", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051098" } ] }, { "name": "haptoglobin N-glycosylated 26 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051099", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051099" } ] }, { "name": "haptoglobin N-glycosylated 27 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-184 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G98425JK. Example: UniProtKB:P00738-1, Asn-184, MOD:00160~GNO:G98425JK. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051100", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051100" } ] }, { "name": "haptoglobin N-glycosylated 28 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051101", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051101" } ] }, { "name": "haptoglobin N-glycosylated 29 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051102", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051102" } ] }, { "name": "haptoglobin N-glycosylated 30 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051103", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051103" } ] }, { "name": "haptoglobin N-glycosylated 31 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G31118FR. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G31118FR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051104", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051104" } ] }, { "name": "haptoglobin N-glycosylated 32 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G36131WL. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G36131WL. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051105", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051105" } ] }, { "name": "haptoglobin N-glycosylated 33 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051106", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051106" } ] }, { "name": "haptoglobin N-glycosylated 34 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G78644BR. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G78644BR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051107", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051107" } ] }, { "name": "haptoglobin N-glycosylated 35 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-207 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00738-1, Asn-207, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051108", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051108" } ] }, { "name": "haptoglobin N-glycosylated 36 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051109", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051109" } ] }, { "name": "haptoglobin N-glycosylated 37 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G26267FS. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G26267FS. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051110", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051110" } ] }, { "name": "haptoglobin N-glycosylated 38 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G31118FR. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G31118FR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051111", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051111" } ] }, { "name": "haptoglobin N-glycosylated 39 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G36131WL. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G36131WL. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051112", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051112" } ] }, { "name": "haptoglobin N-glycosylated 40 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G44576HQ. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G44576HQ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051113", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051113" } ] }, { "name": "haptoglobin N-glycosylated 41 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G62165AG. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G62165AG. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051114", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051114" } ] }, { "name": "haptoglobin N-glycosylated 42 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-211 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G78644BR. Example: UniProtKB:P00738-1, Asn-211, MOD:00160~GNO:G78644BR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051115", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051115" } ] }, { "name": "haptoglobin N-glycosylated 43 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051116", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051116" } ] }, { "name": "haptoglobin N-glycosylated 44 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051117", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051117" } ] }, { "name": "haptoglobin N-glycosylated 45 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051118", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051118" } ] }, { "name": "haptoglobin N-glycosylated 46 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G10486CT. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051119", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051119" } ] }, { "name": "haptoglobin N-glycosylated 47 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G11115RO. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G11115RO. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051120", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051120" } ] }, { "name": "haptoglobin N-glycosylated 48 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G18013WR. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G18013WR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051121", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051121" } ] }, { "name": "haptoglobin N-glycosylated 49 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:18214858, PMID:19838169]", "evidence": [ { "id": "PR:000051122", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051122" } ] }, { "name": "haptoglobin N-glycosylated 50 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G26267FS. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G26267FS. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051123", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051123" } ] }, { "name": "haptoglobin N-glycosylated 51 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G27947YN. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051124", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051124" } ] }, { "name": "haptoglobin N-glycosylated 52 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G28003YJ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G28003YJ. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051125", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051125" } ] }, { "name": "haptoglobin N-glycosylated 53 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G30048DT. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G30048DT. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051126", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051126" } ] }, { "name": "haptoglobin N-glycosylated 54 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G31118FR. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G31118FR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051127", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051127" } ] }, { "name": "haptoglobin N-glycosylated 55 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G31153XO. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G31153XO. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051128", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051128" } ] }, { "name": "haptoglobin N-glycosylated 56 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G32926LW. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G32926LW. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051129", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051129" } ] }, { "name": "haptoglobin N-glycosylated 57 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G36131WL. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G36131WL. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051130", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051130" } ] }, { "name": "haptoglobin N-glycosylated 58 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G37868ZX. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G37868ZX. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051131", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051131" } ] }, { "name": "haptoglobin N-glycosylated 59 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G40926MX. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G40926MX. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051132", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051132" } ] }, { "name": "haptoglobin N-glycosylated 60 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G41044JW. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G41044JW. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051133", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051133" } ] }, { "name": "haptoglobin N-glycosylated 61 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G42358LZ. [PRO:DNx, PMID:18214858, PMID:24279413]", "evidence": [ { "id": "PR:000051134", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051134" } ] }, { "name": "haptoglobin N-glycosylated 62 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G43669FQ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G43669FQ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051135", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051135" } ] }, { "name": "haptoglobin N-glycosylated 63 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G44753VC. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G44753VC. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051136", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051136" } ] }, { "name": "haptoglobin N-glycosylated 64 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G45504EY. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G45504EY. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051137", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051137" } ] }, { "name": "haptoglobin N-glycosylated 65 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G51941GC. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G51941GC. [PRO:DNx, PMID:24279413]", "evidence": [ { "id": "PR:000051138", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051138" } ] }, { "name": "haptoglobin N-glycosylated 66 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G58232MG. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G58232MG. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051139", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051139" } ] }, { "name": "haptoglobin N-glycosylated 67 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051140", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051140" } ] }, { "name": "haptoglobin N-glycosylated 68 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G60033FS. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G60033FS. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051141", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051141" } ] }, { "name": "haptoglobin N-glycosylated 69 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G62165AG. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G62165AG. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051142", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051142" } ] }, { "name": "haptoglobin N-glycosylated 70 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G72309KR. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G72309KR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051143", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051143" } ] }, { "name": "haptoglobin N-glycosylated 71 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G73686WG. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G73686WG. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051144", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051144" } ] }, { "name": "haptoglobin N-glycosylated 72 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G78019KD. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G78019KD. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051145", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051145" } ] }, { "name": "haptoglobin N-glycosylated 73 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G78644BR. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G78644BR. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051146", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051146" } ] }, { "name": "haptoglobin N-glycosylated 74 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G81247ZO. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G81247ZO. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051147", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051147" } ] }, { "name": "haptoglobin N-glycosylated 75 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G83009TH. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G83009TH. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051148", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051148" } ] }, { "name": "haptoglobin N-glycosylated 76 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G83213GG. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G83213GG. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051149", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051149" } ] }, { "name": "haptoglobin N-glycosylated 77 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G83646BJ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G83646BJ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051150", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051150" } ] }, { "name": "haptoglobin N-glycosylated 78 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G85144OK. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G85144OK. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051151", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051151" } ] }, { "name": "haptoglobin N-glycosylated 79 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G86752LQ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G86752LQ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051152", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051152" } ] }, { "name": "haptoglobin N-glycosylated 80 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051153", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051153" } ] }, { "name": "haptoglobin N-glycosylated 81 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G93860XO. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G93860XO. [PRO:DNx, PMID:24279413]", "evidence": [ { "id": "PR:000051154", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051154" } ] }, { "name": "haptoglobin N-glycosylated 82 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan structure is represented by GlyTouCan:G93999ON. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G93999ON. [PRO:DNx, PMID:18214858]", "evidence": [ { "id": "PR:000051155", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051155" } ] }, { "name": "haptoglobin N-glycosylated 83 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051156", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051156" } ] }, { "name": "haptoglobin N-glycosylated 84 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G95678HJ. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G95678HJ. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051157", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051157" } ] }, { "name": "haptoglobin N-glycosylated 85 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G95865ZB. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G95865ZB. [PRO:DNx, PMID:24841998, PMID:29671580]", "evidence": [ { "id": "PR:000051158", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051158" } ] }, { "name": "haptoglobin N-glycosylated 86 (human)", "definition": "A haptoglobin (human) that has been N-glycosylated at the residue equivalent to Asn-241 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G99679NM. Example: UniProtKB:P00738-1, Asn-241, MOD:00160~GNO:G99679NM. [PRO:DNx, PMID:29671580]", "evidence": [ { "id": "PR:000051159", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051159" } ] }, { "name": "haptoglobin O-glycosylated 1 (human)", "definition": "A haptoglobin (human) that has been O-glycosylated at the residue equivalent to Thr-187 of the amino acid sequence represented by UniProtKB:P00738-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00738-1, Thr-187, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000051160", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000051160" } ] } ], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 207, "end_pos": 209, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" }, { "start_pos": 241, "end_pos": 243, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [ { "assessed_biomarker_entity": "Haptoglobin (HP)", "biomarker_id": "A0153", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "27648369", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27648369" } ], "instances": [ { "best_biomarker_type": "diagnostic", "status": "increased HP level", "disease": { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] }, "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "27648369", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27648369" } ] } ] }, { "assessed_biomarker_entity": "Glyco-typer 50 N-glycan liver disease panel", "biomarker_id": "A0245", "evidence": [ { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" }, { "id": "31721442", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31721442" }, { "id": "31177770", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31177770" } ], "instances": [ { "best_biomarker_type": "monitoring", "status": "MALDI-MS measured N-glycans", "disease": { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, "tissue": { "name": "blood", "namespace": "UBERON", "id": "0000178", "url": "http://purl.obolibrary.org/obo/UBERON_0000178" }, "evidence": [ { "id": "GLY_000737", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000737" }, { "id": "31721442", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31721442" }, { "id": "31177770", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31177770" }, { "id": "GLY_000625", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000625" } ] } ] } ], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 135, 184, 207, 211, 241 ], "o_linked_sites": [ 187, 243 ], "snv_sites": [ 184, 187, 205, 207, 211, 213, 220, 243, 255, 261, 289, 291, 321 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 184, "end_pos": 186 }, { "start_pos": 207, "end_pos": 209 }, { "start_pos": 211, "end_pos": 213 }, { "start_pos": 241, "end_pos": 243 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 354 }, { "field": "total_sites", "count": 7 }, { "field": "n_linked_glycans", "count": 173 }, { "field": "n_linked_glycan_sites", "count": 9 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", 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"table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 15 }, { "field": "total_sites", "count": 13 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 98 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }