{
"uniprot_canonical_ac": "P00450-1",
"uniprot_ac": "P00450",
"uniprot_id": "CERU_HUMAN",
"mass": {
"chemical_mass": 122219.0,
"monoisotopic_mass": 122219.0
},
"refseq": {
"ac": "NP_000087",
"name": "ceruloplasmin precursor",
"summary": "The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087"
},
"gene_names": [
{
"name": "CP",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/P00450",
"id": "P00450"
},
{
"name": "AB073614; CP-2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087",
"id": "NP_000087"
},
{
"name": "CP",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087",
"id": "NP_000087"
}
],
"protein_names": [
{
"name": "Ceruloplasmin",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "P00450"
},
{
"name": "1.16.3.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P00450"
},
{
"name": "Ferroxidase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "P00450"
},
{
"name": "ceruloplasmin (ferroxidase)",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087",
"id": "NP_000087"
},
{
"name": "ceruloplasmin precursor",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087",
"id": "NP_000087"
}
],
"function": [
{
"annotation": "Ceruloplasmin Reduces the Lactoferrin/Oleic Acid Antitumor Complex-Mediated Release of Heme-Containing Proteins from Blood Cells. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000087",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087"
},
{
"database": "PubMed",
"id": "38069040",
"url": "https://glygen.org/publication/PubMed/38069040"
}
]
},
{
"annotation": "Ceruloplasmin as Redox Marker Related to Heart Failure Severity. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000087",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087"
},
{
"database": "PubMed",
"id": "34576235",
"url": "https://glygen.org/publication/PubMed/34576235"
}
]
},
{
"annotation": "Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450#function"
}
]
},
{
"annotation": "Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000087",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087"
},
{
"database": "PubMed",
"id": "35029158",
"url": "https://glygen.org/publication/PubMed/35029158"
}
]
},
{
"annotation": "The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000087",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087"
}
]
},
{
"annotation": "Wilson's disease: overview. Review article",
"evidence": [
{
"database": "RefSeq",
"id": "NP_000087",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_000087"
},
{
"database": "PubMed",
"id": "36697289",
"url": "https://glygen.org/publication/PubMed/36697289"
}
]
}
],
"disease": [
{
"disease_id": "DOID:0050711",
"recommended_name": {
"id": "DOID:0050711",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:0050711",
"name": "aceruloplasminemia",
"description": "An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus."
},
"synonyms": [
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "aceruloplasminemia",
"description": "An adult-onset disorder of neurodegeneration with brain iron accumulation (NBIA) characterized by anemia, retinal degeneration, diabetes and various neurological symptoms."
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "cerebellar ataxia",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "aceruloplasminemia",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "hereditary ceruloplasmin deficiency",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "hypoceruloplasminemia, hereditary",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "ceruloplasmin deficiency",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "familial apoceruloplasmin deficiency",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "hemosiderosis, systemic, due to aceruloplasminemia",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "hypoceruloplasminemia",
"description": ""
},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "systemic hemosiderosis due to aceruloplasminemia",
"description": ""
},
{
"id": "MIM:604290",
"resource": "MIM",
"url": "https://www.omim.org/entry/604290",
"name": "Aceruloplasminemia",
"description": "Aceruloplasminemia"
}
],
"evidence": [
{
"id": "604290",
"database": "MIM",
"url": "https://www.omim.org/entry/604290"
}
]
}
],
"snv": [
{
"evidence": [
{
"id": "rs754375289",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754375289"
},
{
"id": "rs754375289",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754375289"
},
{
"id": "rs754375289",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs754375289#frequency_tab"
},
{
"id": "rs754375289",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs754375289"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 360,
"end_pos": 360,
"sequence_org": "S",
"sequence_mut": "Y",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NKS->NKY); o-glyco-site-loss (S->Y).",
"chr_id": "3",
"chr_pos": "149206297",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S360",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1559958662",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1559958662"
},
{
"id": "rs1559958662",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs1559958662"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 137,
"end_pos": 137,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DNT->NNT).",
"chr_id": "3",
"chr_pos": "149210365",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D137",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs757785679",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757785679"
},
{
"id": "rs757785679",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757785679"
},
{
"id": "rs757785679",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs757785679"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 138,
"end_pos": 138,
"sequence_org": "N",
"sequence_mut": "K",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->KTT).",
"chr_id": "3",
"chr_pos": "149210360",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N138",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs148809294",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148809294"
},
{
"id": "rs148809294",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs148809294"
},
{
"id": "rs148809294",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs148809294"
},
{
"id": "rs148809294",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs148809294#frequency_tab"
},
{
"id": "rs148809294",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs148809294"
}
],
"glycoeffect": [
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],
"start_pos": 29,
"end_pos": 29,
"sequence_org": "I",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IET->NET).",
"chr_id": "3",
"chr_pos": "149178612",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "0.0002",
"site_lbl": "I29",
"keywords": [
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"germline"
]
},
{
"evidence": [
{
"id": "rs767161351",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767161351"
},
{
"id": "rs767161351",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs767161351"
},
{
"id": "rs767161351",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs767161351#frequency_tab"
},
{
"id": "rs767161351",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs767161351"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 310,
"end_pos": 310,
"sequence_org": "R",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NYR->NYS).",
"chr_id": "3",
"chr_pos": "149207471",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "R310",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1364319813",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1364319813"
},
{
"id": "rs1364319813",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1364319813"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 359,
"end_pos": 359,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KSS->NSS).",
"chr_id": "3",
"chr_pos": "149206299",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K359",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1481132976",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1481132976"
},
{
"id": "rs1481132976",
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"url": "https://www.ncbi.nlm.nih.gov/snp/rs1481132976#frequency_tab"
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{
"id": "rs1481132976",
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],
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],
"start_pos": 392,
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"sequence_org": "I",
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"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IFT->NFT).",
"chr_id": "3",
"chr_pos": "149206201",
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"site_lbl": "I392",
"disease": [
{
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},
{
"id": "MONDO:0011426",
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},
{
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},
{
"id": "MONDO:0011426",
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},
{
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},
{
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},
{
"id": "MONDO:0011426",
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},
{
"id": "MONDO:0011426",
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},
{
"id": "MONDO:0011426",
"resource": "MONDO",
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},
{
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},
{
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]
}
],
"keywords": [
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},
{
"evidence": [
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},
{
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{
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},
{
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{
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],
"glycoeffect": [
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],
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"chr_id": "3",
"chr_pos": "149206185",
"ref_nt": "C",
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{
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},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
"name": "cerebellar ataxia",
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},
{
"id": "MONDO:0011426",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011426",
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},
{
"id": "MONDO:0011426",
"resource": "MONDO",
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},
{
"id": "MONDO:0011426",
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},
{
"id": "MONDO:0011426",
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},
{
"id": "MONDO:0011426",
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},
{
"id": "MONDO:0011426",
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},
{
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},
{
"id": "MONDO:0011426",
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},
{
"id": "MIM:604290",
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}
]
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],
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{
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{
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{
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},
{
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{
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{
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],
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"chr_id": "3",
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},
{
"evidence": [
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{
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{
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"chr_id": "3",
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},
{
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{
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{
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{
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],
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"sequence_org": "N",
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"chr_id": "3",
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}
],
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{
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"id": "0000082",
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"present": "MEDIUM",
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]
},
{
"tissue": {
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"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
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"score": "75.25",
"present": "MEDIUM",
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]
},
{
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]
},
{
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"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
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"score": "49.96",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000047457",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000047457"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
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"score": "88.93",
"present": "HIGH",
"evidence": [
{
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"id": "ENSG00000047457",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000047457"
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]
},
{
"tissue": {
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"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
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"score": "92.46",
"present": "HIGH",
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{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000047457"
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]
},
{
"tissue": {
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"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
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"score": "47.76",
"present": "LOW",
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]
},
{
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"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
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"present": "MEDIUM",
"evidence": [
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"id": "ENSG00000047457",
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]
},
{
"tissue": {
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"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
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"score": "85.12",
"present": "HIGH",
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{
"database": "Bgee",
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"url": "https://bgee.org/?page=gene&gene_id=ENSG00000047457"
}
]
},
{
"tissue": {
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"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
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]
},
{
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]
},
{
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]
},
{
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],
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{
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{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
"id": "MONDO:0012741",
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},
{
"id": "MONDO:0012741",
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"url": "https://monarchinitiative.org/disease/MONDO:0012741",
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},
{
"id": "MONDO:0012741",
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},
{
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{
"id": "MONDO:0012741",
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"name": "HPC12",
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},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
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},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
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},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
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},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
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},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
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},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
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"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
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},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
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],
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{
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"resource": "Disease Ontology",
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"synonyms": [
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},
{
"id": "DOID:10534",
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{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
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},
{
"id": "MONDO:0001056",
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"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
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},
{
"id": "MONDO:0001056",
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"name": "malignant tumour of body of stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
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},
{
"id": "MONDO:0001056",
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"name": "malignant tumour of lesser curve of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"name": "stomach cancer",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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},
{
"id": "MONDO:0001056",
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"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
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}
]
}
]
},
{
"significant": "Yes",
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"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
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},
{
"id": "DOID:11054",
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"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
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},
{
"id": "MONDO:0001187",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant neoplasm of bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of the bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"name": "malignant neoplasm, bladder",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"name": "malignant tumor of the urinary bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
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},
{
"id": "MONDO:0001187",
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"name": "malignant urinary bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "P00450",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00450"
}
],
"disease": [
{
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"name": "esophageal cancer",
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},
"synonyms": [
{
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"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
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"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
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"name": "malignant esophageal tumour",
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},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
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"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
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},
{
"id": "MONDO:0007576",
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"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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},
{
"id": "MONDO:0007576",
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"name": "malignant tumour of oesophagus",
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},
{
"id": "MONDO:0007576",
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"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
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"name": "Ca lower third oesophagus",
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},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
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"name": "malignant tumour of proximal third of oesophagus",
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},
{
"id": "MONDO:0007576",
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"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
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"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
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"name": "Esophageal cancer",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
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{
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"id": "P00450",
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],
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{
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},
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},
{
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},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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"name": "colon cancer, somatic",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
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},
{
"id": "MONDO:0005575",
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"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
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},
{
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},
{
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},
{
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},
{
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},
{
"id": "MONDO:0005575",
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},
{
"id": "MONDO:0005575",
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"name": "malignant colorectal tumour",
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},
{
"id": "MONDO:0005575",
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},
{
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},
{
"id": "MONDO:0005575",
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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},
{
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},
{
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{
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},
{
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},
{
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},
{
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},
{
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},
{
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},
{
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]
},
{
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},
{
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},
{
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}
],
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"length": 1065,
"header": "sp|P00450-1|CERU_HUMAN Isoform 1 of Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=2 CANONICAL=P00450-1"
},
"isoforms": [
{
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"url": "",
"sequence": {
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"length": 178,
"header": "tr|D6RE86-1|D6RE86_HUMAN Computationally mapped isoform of Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=8 CANONICAL=P00450-1"
},
"locus": {
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"start_pos": 149221792,
"end_pos": 149210360,
"strand": "+",
"evidence": [
{
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"id": "ENST00000455472.3",
"url": "https://www.ensembl.org/id/ENST00000455472.3"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000426888.1",
"url": "https://www.ensembl.org/id/ENSP00000426888.1"
}
]
}
},
{
"isoform_ac": "E9PFZ2-1",
"url": "",
"sequence": {
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"length": 946,
"header": "tr|E9PFZ2-1|E9PFZ2_HUMAN Computationally mapped isoform of Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1 CANONICAL=P00450-1"
},
"locus": {
"chromosome": "3",
"start_pos": 149221792,
"end_pos": 149166018,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000481169.5",
"url": "https://www.ensembl.org/id/ENST00000481169.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000418773.1",
"url": "https://www.ensembl.org/id/ENSP00000418773.1"
}
]
}
},
{
"isoform_ac": "H7C5N5-1",
"url": "",
"sequence": {
"sequence": "GAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEASSETHRRIWNVIYPITVSVIILFQISTKE",
"length": 225,
"header": "tr|H7C5N5-1|H7C5N5_HUMAN Computationally mapped isoform of Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1 CANONICAL=P00450-1"
},
"locus": {
"chromosome": "3",
"start_pos": 149179621,
"end_pos": 149165962,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000479771.5",
"url": "https://www.ensembl.org/id/ENST00000479771.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000420367.1",
"url": "https://www.ensembl.org/id/ENSP00000420367.1"
}
]
}
},
{
"isoform_ac": "H7C5R1-1",
"url": "",
"sequence": {
"sequence": "VVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEGEYPDTKSG",
"length": 852,
"header": "tr|H7C5R1-1|H7C5R1_HUMAN Computationally mapped isoform of Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=1 CANONICAL=P00450-1"
},
"locus": {
"chromosome": "3",
"start_pos": 149209340,
"end_pos": 149173717,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000494544.1",
"url": "https://www.ensembl.org/id/ENST00000494544.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000420545.1",
"url": "https://www.ensembl.org/id/ENSP00000420545.1"
}
]
}
},
{
"isoform_ac": "P00450-1",
"url": "",
"sequence": {
"sequence": "MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG",
"length": 1065,
"header": "sp|P00450-1|CERU_HUMAN Isoform 1 of Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP PE=1 SV=2 CANONICAL=P00450-1"
},
"locus": {}
}
],
"glycosylation": [
{
"glytoucan_ac": "G57321FI",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "EHEGAIYPDNTTDFQR",
"relation": "attached",
"comment": "",
"start_pos": 129,
"start_aa": "Glu",
"end_pos": 144,
"end_aa": "Arg",
"evidence": [
{
"id": "P00450",
"database": "UniCarbKB",
"url": ""
},
{
"id": "28035807",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/28035807"
},
{
"id": "10.1021/acs.analchem.6b02887",
"database": "DOI",
"url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.6b02887"
}
]
},
{
"glytoucan_ac": "G57321FI",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "EHEGAIYPDNTTDFQRADDK",
"relation": "attached",
"comment": "",
"start_pos": 129,
"start_aa": "Glu",
"end_pos": 148,
"end_aa": "Lys",
"evidence": [
{
"id": "P00450",
"database": "UniCarbKB",
"url": ""
},
{
"id": "28035807",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/28035807"
},
{
"id": "10.1021/acs.analchem.6b02887",
"database": "DOI",
"url": "https://glygen.org/publication/DOI/10.1021/acs.analchem.6b02887"
}
]
},
{
"glytoucan_ac": "G00912UN",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 138,
"start_aa": "Asn",
"end_pos": 138,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn138",
"evidence": [
{
"id": "P00450",
"database": "UniCarbKB",
"url": ""
},
{
"id": "16321355",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/16321355"
},
{
"id": "24841998",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/24841998"
},
{
"id": "29671580",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29671580"
},
{
"id": "P00450@N138",
"database": "GPTwiki",
"url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00450@N138"
}
]
},
{
"glytoucan_ac": "G03596YS",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 138,
"start_aa": "Asn",
"end_pos": 138,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn138",
"evidence": [
{
"id": "P00450@N138",
"database": "GPTwiki",
"url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00450@N138"
}
]
},
{
"glytoucan_ac": "G05933EN",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 138,
"start_aa": "Asn",
"end_pos": 138,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn138",
"evidence": [
{
"id": "P00450@N138",
"database": "GPTwiki",
"url": "https://edwardslab.bmcb.georgetown.edu/gptwiki/P00450@N138"
}
]
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"database": "PubMed",
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]
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]
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{
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{
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]
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"id": "R-HSA-381426",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426"
}
],
"reference": [
{
"type": "PubMed",
"id": "9497324",
"url": "https://glygen.org/publication/PubMed/9497324"
}
]
},
{
"title": "Identification of novel high molecular weight insulin-like growth factor-binding protein-3 association proteins in human serum.",
"journal": "The Journal of clinical endocrinology and metabolism",
"date": "1998",
"authors": "Collett-Solberg PF, Nunn SE, Gibson TB, Cohen P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-381426",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426"
}
],
"reference": [
{
"type": "PubMed",
"id": "9709957",
"url": "https://glygen.org/publication/PubMed/9709957"
}
]
},
{
"title": "The insulin-like growth factor (IGF)binding protein 1 binding epitope on IGF-I probed by heteronuclear NMR spectroscopy and mutational analysis.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Jansson M, Andersson G, Uhlen M, Nilsson B, Kordel J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-381426",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426"
}
],
"reference": [
{
"type": "PubMed",
"id": "9733769",
"url": "https://glygen.org/publication/PubMed/9733769"
}
]
},
{
"title": "Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Twigg SM, Kiefer MC, Zapf J, Baxter RC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-381426",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426"
}
],
"reference": [
{
"type": "PubMed",
"id": "9786878",
"url": "https://glygen.org/publication/PubMed/9786878"
}
]
},
{
"title": "Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.",
"journal": "American journal of respiratory cell and molecular biology",
"date": "1999",
"authors": "Rajah R, Nachajon RV, Collins MH, Hakonarson H, Grunstein MM, Cohen P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-381426",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426"
}
],
"reference": [
{
"type": "PubMed",
"id": "9922210",
"url": "https://glygen.org/publication/PubMed/9922210"
}
]
}
],
"pathway": [
{
"id": "hsa:1356",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1356",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-381426",
"name": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-381426",
"resource": "Reactome",
"description": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
},
{
"id": "R-HSA-425410",
"name": "Metal ion SLC transporters",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-425410",
"resource": "Reactome",
"description": "Metal ion SLC transporters"
},
{
"id": "R-HSA-5619049",
"name": "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5619049",
"resource": "Reactome",
"description": "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)"
},
{
"id": "R-HSA-5619060",
"name": "Defective CP causes aceruloplasminemia (ACERULOP)",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5619060",
"resource": "Reactome",
"description": "Defective CP causes aceruloplasminemia (ACERULOP)"
},
{
"id": "R-HSA-8957275",
"name": "Post-translational protein phosphorylation",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8957275",
"resource": "Reactome",
"description": "Post-translational protein phosphorylation"
},
{
"id": "R-HSA-917937",
"name": "Iron uptake and transport",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-917937",
"resource": "Reactome",
"description": "Iron uptake and transport"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "P13635-1",
"protein_name": "Ceruloplasmin",
"gene_name": "Cp",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MKFLLLSALLFLHSSLAWTREKHYYIGITEAVWDYASGSEEKELISVDTEQSNFYLRNGPDRIGRKYKKALYSEYTDGTFTKTIDKPAWLGFLGPVIKAEVGDKVSVHVKNFASRPYTFHAHGVTYTKANEGAIYPDNTTDFQRADDKLFPGQQYLYVLRANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLHKEKEENIDQEFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHSELFHGQALTSKNYHTDIINLFPATLIDVSMVAQNPGVWMLSCQNLNHLKAGLQAFFQVRDCNKPSPDDDIQDRHVRHYYIAAEETIWDYAPSGTDTFTGENFTSLGSDSRVFFEQGATRIGGSYKKLVYREYTDDSFTNRKERGPDEEHLGILGPVIWAEVGDIIRVTFHNKGQFPLSIQPMGVRFTKENEGTYYGPDGRSSKQASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDLTKDIFTGLIGPMKICKKGSLLADGRQKDVDKEFYLFATVFDENESLLLDDNIRMFTTAPENVDKEDEDFQESNKMHSMNGFMYGNLPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMTPDTEGSFDVECLTTDHYTGGMKQKYTVNQCKGQFEDVTLYQGERTYYIAAVEVEWDYSPSRDWEMELHHLQEQNVSNAFLDKEEFFIGSKYKKVVYREFTDSTFREQVKRRAEEEHLGMLGPLIHADVGAKVKVVFKNMATRPYSIHAHGVKTKSSTVAPTLPGEVRTYIWQIPERSGAGTEDSPCIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFNPKKKMEFSLLFLVFDENESWYLDDNINTYPDHPEKDNKDNEEFIESNKMHAINGKMFGNLQGLTMHVGDEVNWYVMAMGNEIDLHTVHFHGHSFQYKHRGIHSSDVFDFFPGTYQTLEMFPQTPGTWLLHCHVTDHIHAGMVTTYTVLPNQETKSG",
"length": 1059
},
"evidence": [
{
"id": "45916686",
"url": "http://www.informatics.jax.org/homology/45916686",
"database": "MGI"
}
],
"common_name": "Rat"
},
{
"uniprot_canonical_ac": "Q61147-1",
"protein_name": "Ceruloplasmin",
"gene_name": "Cp",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MKFLLLSTFIFLYSSLALARDKHYFIGITEAVWDYASGTEEKKLISVDTEQSNFYLQNGPDRIGRKYKKALYFEYTDGTFSKTIDKPAWLGFLGPVIKAEVEDKVYVHLKNLASRIYTFHAHGVTYTKEYEGAVYPDNTTDFQRADDKVLPGQQYVYVLHANEPSPGEGDSNCVTRIYHSHVDAPKDIASGLIGPLILCKKGSLYKEKEKNIDQEFVLMFSVVDENLSWYLEDNIKTFCSEPEKVDKDNEDFQESNRMYSINGYTFGSLPGLSMCAADRVKWYLFGMGNEVDVHSAFFHGQALTSRNYQTDIINLFPATLIDAYMVAQNPGVWMLSCQNLNHLKAGLQAFFQVRDCNKPSPEDNIQDRHVRHYYIAAEEVIWNYAPSGTDIFTGENLTALESDSRVFFEQGATRIGGSYKKMAYREYTDGSFTNRKQRGPDEEHLGILGPVIWAEVGDTIKVTFHNKGQHPLSIQPMGVSFTAENEGTYYGPPGRSSQQAASHVAPKETFTYEWTVPKEMGPTYADPVCLSKMYYSGVDPTKDIFTGLIGPMKICKKGSLLADGRQKDVDKEFYLFPTVFDENESLLLDDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLNMCLGESIVWYLFSAGNEADVHGIYFSGNTYLSKGERRDTANLFPHKSLTLLMNPDTKGTFDVECLTTDHYTGGMKQKYTVNQCQRQFEDFTVYLGERTYYVAAVEVEWDYSPSRAWEKELHHLQEQNVSNVFLDKEEFFIGSKYKKVVYRQFTDSSFREQVKRRAEDEHLGILGPPIHANVGDKVKVVFKNMATRPYSIHAHGVKTESSTVVPTLPGEVRTYTWQIPERSGAGREDSACIPWAYYSTVDRVKDLYSGLIGPLIVCRKSYVKVFSPKKKMEFFLLFLVFDENESWYLDDNIKTYSEHPEKVNKDNEEFLESNKMHAINGKMFGNLQGLTMHVKDEVNWYVMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDLFPGTYQTLEMFPQTPGTWLLHCHVTDHVHAGMATTYTVLPVEQETKSG",
"length": 1061
},
"evidence": [
{
"id": "45916686",
"url": "http://www.informatics.jax.org/homology/45916686",
"database": "MGI"
}
],
"common_name": "Mouse"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 4,
"go_terms": [
{
"name": "oxidoreductase activity",
"id": "GO:0016491",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "copper ion binding",
"id": "GO:0005507",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005507",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "protein-folding chaperone binding",
"id": "GO:0051087",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "ferroxidase activity",
"id": "GO:0004322",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004322",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 8,
"go_terms": [
{
"name": "extracellular region",
"id": "GO:0005576",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "extracellular space",
"id": "GO:0005615",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "endoplasmic reticulum lumen",
"id": "GO:0005788",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "extracellular exosome",
"id": "GO:0070062",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "blood microparticle",
"id": "GO:0072562",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072562",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "lysosomal membrane",
"id": "GO:0005765",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "cellular anatomical entity",
"id": "GO:0110165",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110165",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 3,
"go_terms": [
{
"name": "intracellular iron ion homeostasis",
"id": "GO:0006879",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006879",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "copper ion transport",
"id": "GO:0006825",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006825",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
},
{
"name": "iron ion transport",
"id": "GO:0006826",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006826",
"evidence": [
{
"database": "UniProtKB",
"id": "P00450",
"url": "https://www.uniprot.org/uniprot/P00450"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [
{
"name": "ceruloplasmin N-glycosylated 1 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:16321355, PMID:24841998, PMID:29671580]",
"evidence": [
{
"id": "PR:000050940",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050940"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 2 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050941",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050941"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 3 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:16321355, PMID:24841998, PMID:29671580]",
"evidence": [
{
"id": "PR:000050942",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050942"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 4 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G10486CT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050943",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050943"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 5 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:19838169]",
"evidence": [
{
"id": "PR:000050944",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050944"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 6 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G27947YN. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050945",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050945"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 7 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G40926MX. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G40926MX. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050946",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050946"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 8 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G41044JW. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G41044JW. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050947",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050947"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 9 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G42358LZ. [PRO:DNx, PMID:24279413]",
"evidence": [
{
"id": "PR:000050948",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050948"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 10 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G45504EY. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G45504EY. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050949",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050949"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 11 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G56749GV. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G56749GV. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050950",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050950"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 12 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050951",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050951"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 13 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G66665YI. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G66665YI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050952",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050952"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 14 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G72580QS. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G72580QS. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050953",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050953"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 15 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G72791KH. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G72791KH. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050954",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050954"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 16 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G83555HU. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050955",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050955"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 17 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G84467IZ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G84467IZ. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050956",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050956"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 18 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G85144OK. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G85144OK. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050957",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050957"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 19 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G86752LQ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G86752LQ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050958",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050958"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 20 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:16321355, PMID:24841998, PMID:29671580]",
"evidence": [
{
"id": "PR:000050959",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050959"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 21 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G89877QI. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G89877QI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050960",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050960"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 22 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050961",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050961"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 23 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G95678HJ. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G95678HJ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050962",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050962"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 24 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-138 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G99679NM. Example: UniProtKB:P00450-1, Asn-138, MOD:00160~GNO:G99679NM. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050963",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050963"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 25 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:16321355, PMID:29671580]",
"evidence": [
{
"id": "PR:000050964",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050964"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 26 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050965",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050965"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 27 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050966",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050966"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 28 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:19838169]",
"evidence": [
{
"id": "PR:000050967",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050967"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 29 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G27947YN. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050968",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050968"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 30 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G42358LZ. [PRO:DNx, PMID:24279413]",
"evidence": [
{
"id": "PR:000050969",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050969"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 31 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G43417UB. [PRO:DNx, PMID:16321355]",
"evidence": [
{
"id": "PR:000050970",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050970"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 32 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G56749GV. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G56749GV. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050971",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050971"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 33 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050972",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050972"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 34 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G66665YI. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G66665YI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050973",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050973"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 35 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G72580QS. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G72580QS. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050974",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050974"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 36 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G84467IZ. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G84467IZ. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050975",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050975"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 37 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050976",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050976"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 38 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G89877QI. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G89877QI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050977",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050977"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 39 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-358 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00450-1, Asn-358, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050978",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050978"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 40 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:16321355, PMID:24841998, PMID:29671580]",
"evidence": [
{
"id": "PR:000050979",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050979"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 41 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050980",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050980"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 42 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24279413]",
"evidence": [
{
"id": "PR:000050981",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050981"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 43 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:16321355, PMID:24841998, PMID:29671580]",
"evidence": [
{
"id": "PR:000050982",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050982"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 44 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G10486CT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050983",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050983"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 45 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G22140GZ. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G22140GZ. [PRO:DNx, PMID:19838169]",
"evidence": [
{
"id": "PR:000050984",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050984"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 46 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G27947YN. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050985",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050985"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 47 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G42358LZ. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G42358LZ. [PRO:DNx, PMID:24279413]",
"evidence": [
{
"id": "PR:000050986",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050986"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 48 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G56749GV. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G56749GV. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050987",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050987"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 49 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050988",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050988"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 50 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G66665YI. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G66665YI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050989",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050989"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 51 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G72580QS. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G72580QS. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050990",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050990"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 52 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G84467IZ. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G84467IZ. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050991",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050991"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 53 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G85144OK. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G85144OK. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050992",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050992"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 54 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050993",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050993"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 55 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G89877QI. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G89877QI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000050994",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050994"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 56 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-397 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00450-1, Asn-397, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050995",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050995"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 57 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G00912UN. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G00912UN. [PRO:DNx, PMID:16321355, PMID:29671580]",
"evidence": [
{
"id": "PR:000050996",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050996"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 58 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G06247RL. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G06247RL. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050997",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050997"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 59 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G08146BT. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G08146BT. [PRO:DNx, PMID:24279413]",
"evidence": [
{
"id": "PR:000050998",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050998"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 60 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G08293MJ. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G08293MJ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000050999",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050999"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 61 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G10486CT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051000",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051000"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 62 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G27947YN. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G27947YN. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051001",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051001"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 63 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G32926LW. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G32926LW. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051002",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051002"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 64 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G36670VW. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G36670VW. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051003",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051003"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 65 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G40926MX. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G40926MX. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051004",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051004"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 66 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G45504EY. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G45504EY. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051005",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051005"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 67 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G56749GV. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G56749GV. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000051006",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051006"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 68 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G59626AS. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G59626AS. [PRO:DNx, PMID:16321355, PMID:29671580]",
"evidence": [
{
"id": "PR:000051007",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051007"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 69 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G66665YI. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G66665YI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000051008",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051008"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 70 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G72580QS. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G72580QS. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000051009",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051009"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 71 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G83555HU. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G83555HU. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051010",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051010"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 72 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G84467IZ. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G84467IZ. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000051011",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051011"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 73 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G85144OK. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G85144OK. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051012",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051012"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 74 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G86752LQ. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G86752LQ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051013",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051013"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 75 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G88374WZ. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G88374WZ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051014",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051014"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 76 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan structure is represented by GlyTouCan:G89877QI. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G89877QI. [PRO:DNx, PMID:7096333, PMID:7451505]",
"evidence": [
{
"id": "PR:000051015",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051015"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 77 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G94917XT. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G94917XT. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051016",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051016"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 78 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G95678HJ. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G95678HJ. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051017",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051017"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 79 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G95865ZB. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G95865ZB. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051018",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051018"
}
]
},
{
"name": "ceruloplasmin N-glycosylated 80 (human)",
"definition": "A ceruloplasmin (human) that has been N-glycosylated at the residue equivalent to Asn-762 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G99679NM. Example: UniProtKB:P00450-1, Asn-762, MOD:00160~GNO:G99679NM. [PRO:DNx, PMID:29671580]",
"evidence": [
{
"id": "PR:000051019",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051019"
}
]
},
{
"name": "ceruloplasmin O-glycosylated 1 (human)",
"definition": "A ceruloplasmin (human) that has been O-glycosylated at the residue equivalent to Ser-492 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00450-1, Ser-492, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000051020",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051020"
}
]
},
{
"name": "ceruloplasmin O-glycosylated 2 (human)",
"definition": "A ceruloplasmin (human) that has been O-glycosylated at the residue equivalent to Ser-505 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00450-1, Ser-505, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000051021",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051021"
}
]
},
{
"name": "ceruloplasmin O-glycosylated 3 (human)",
"definition": "A ceruloplasmin (human) that has been O-glycosylated at the residue equivalent to Ser-507 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00450-1, Ser-507, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000051022",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051022"
}
]
},
{
"name": "ceruloplasmin O-glycosylated 4 (human)",
"definition": "A ceruloplasmin (human) that has been O-glycosylated at the residue equivalent to Thr-489 of the amino acid sequence represented by UniProtKB:P00450-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P00450-1, Thr-489, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000051023",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000051023"
}
]
}
],
"site_annotation": [
{
"start_pos": 138,
"end_pos": 140,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 227,
"end_pos": 229,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 358,
"end_pos": 360,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 397,
"end_pos": 399,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 588,
"end_pos": 590,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 762,
"end_pos": 764,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 926,
"end_pos": 928,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "11148",
"name": "",
"equation": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P19132-1",
"D3ZYW7-1",
"P13635-1",
"P00450-1",
"Q6MZM0-1",
"Q8N4E7-1",
"P02794-1",
"Q16595-1",
"Q61147-1",
"P09528-1",
"O35943-1",
"Q9D5H4-1",
"Q3V1H3-1",
"P38993-1",
"Q07540-1",
"Q54C45-1",
"Q9W385-1",
"Q9VYH1-1",
"Q7KRU8-1"
],
"evidence": [
{
"id": "11148",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/11148"
}
]
},
{
"id": "R-HSA-5621402",
"name": "Defective CP does not oxidise Fe2+ to Fe3+",
"equation": "",
"summary": "Ceruloplasmin (CP), synthesised in the liver and secreted into plasma, is a copper-binding (6-7 atoms per molecule) glycoprotein involved in iron trafficking in vertebrates. CP is essential for SLC40A1 (ferroportin) stability at the cell surface, the protein that mediates iron efflux from cells. CP also possesses ferroxidase activity, which oxidises ferrous iron (Fe2+) to ferric iron (Fe3+) following its transfer out of the cell. Defects in CP (or indeed SLC40A1) can lead to the phenotype of iron overload as seen in the disorder aceruloplasminemia (ACERULOP; MIM:604290). It is a rare autosomal recessive disorder of iron metabolism characterised by iron accumulation mainly in the brain, but also in liver, pancreas and retina. Patients develop retinal degeneration, diabetes mellitus and neurological disturbance.
Mutations that can cause ACERULOP include W858*, E797Rfs*12, D411Tfs*36 and 778fs*12 (Takahashi et al. 1996, Logan et al. 1994, Okamoto et al. 1996, Harris et al. 1995).",
"cellular_location": "extracellular region, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00450-1"
],
"evidence": [
{
"id": "R-HSA-5621402",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5621402"
}
]
},
{
"id": "R-HSA-5655733",
"name": "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region",
"equation": "",
"summary": "SLC40A1 (MTP1 aka ferroportin or IREG1) is highly expressed on macrophages where it mediates iron efflux from the breakdown of haem. Normally, SLC40A1 colocalises with ceruloplasmin (CP) which stablizes SLC40A1 and is necessary for the efflux reaction to occur. In addition, six copper ions are required by ceruloplasmin as a cofactor.
Defects in SLC40A1 can cause hemochromatosis 4 (HFE4; MIM:606069), a disorder of iron metabolism characterised by iron overload. Excess iron is deposited in a variety of organs leading to their failure, resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis and hypogonadotropic hypogonadism. Severe effects of the disease don't usually appear until after decades of progressive iron overloading. Mutations causing HFE4 include N144H, A77D, V162del, G80V, D181V and D157G (Njajou et al. 2001, Agarwal et al. 2006, Wallace et al. 2002, Cremonesi et al. 2005, Hetet et al. 2003).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00450-1"
],
"evidence": [
{
"id": "R-HSA-5655733",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5655733"
}
]
},
{
"id": "R-HSA-8952289",
"name": "FAM20C phosphorylates FAM20C substrates",
"equation": "",
"summary": "Extracellular serine/threonine protein kinase FAM20C is an extracellular kinase that can phosphorylate a broad range of secreted protein. FAM20C is bound and allosterically activated by the pseudokinase FAM20A (Tagliabracchi et al. 2012, 2015, Cui et al. 2015).
Loss of function mutations in Fam20C cause Raine Syndrome, an osteosclerotic bone dysplasia (Faundes et al. 2014).",
"cellular_location": "endoplasmic reticulum lumen",
"input_participant_list": [
"R-ALL-8931885"
],
"output_participant_list": [
"R-ALL-8931884"
],
"enzyme_list": [
"Q6P988-1",
"P07237-1",
"O14672-1",
"Q8NBP7-1",
"Q8IXL6-1",
"P00450-1",
"P04070-1",
"Q9BTY2-1",
"Q96AD5-1",
"Q14703-1",
"Q9UM21-1",
"Q15084-1",
"O95084-1",
"O00391-1"
],
"evidence": [
{
"id": "R-HSA-8952289",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8952289"
}
]
},
{
"id": "R-HSA-904830",
"name": "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region",
"equation": "",
"summary": "SLC40A1 (MTP1 aka ferroportin or IREG1) is highly expressed on macrophages where it mediates iron efflux from the breakdown of haem (Schimanski et al. 2005). SLC40A1 colocalizes with ceruloplasmin (CP) which stablizes SLC40A1 and is necessary for the efflux reaction to occur (Texel et al. 2008). Six copper ions are required as cofactor. Ceruloplasmin (CP) also catalyses the conversion of iron from ferrous (Fe2+) to ferric form (Fe3+), thereby assisting in its transport in the plasma in association with transferrin, which can only carry iron in the ferric state. As well as being expressed on macrophages, SLC40A1 is also highly expressed in the duodenum, placenta (where it may mediate the transport of iron from maternal to foetal circulation), muscle and spleen.",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P00450-1"
],
"evidence": [
{
"id": "R-HSA-904830",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-904830"
}
]
},
{
"id": "R-HSA-917891",
"name": "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+",
"equation": "",
"summary": "In tissues other than the duodenum, ceruloplasmin (CP), in complex with SLC40A1 and 6 copper ions, oxidises ferrous iron (Fe2+) to ferric iron (Fe3+) after it is exported from the cell (Sato et al. 1990).",
"cellular_location": "external side of plasma membrane",
"input_participant_list": [],
"output_participant_list": [
"R-ALL-912516"
],
"enzyme_list": [
"P00450-1"
],
"evidence": [
{
"id": "R-HSA-917891",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-917891"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-8931884",
"participant_name": "ADP [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "C00008",
"database": "COMPOUND",
"url": ""
},
{
"id": "456216",
"database": "ChEBI",
"url": ""
},
{
"id": "000012360703",
"database": "ZINC",
"url": ""
},
{
"id": "C00008",
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},
{
"id": "000012360703",
"database": "ZINC",
"url": ""
},
{
"id": "456216",
"database": "ChEBI",
"url": ""
},
{
"id": "456216",
"database": "ChEBI",
"url": ""
},
{
"id": "C00008",
"database": "COMPOUND",
"url": ""
},
{
"id": "000012360703",
"database": "ZINC",
"url": ""
},
{
"id": "C00008",
"database": "COMPOUND",
"url": ""
},
{
"id": "456216",
"database": "ChEBI",
"url": ""
},
{
"id": "000012360703",
"database": "ZINC",
"url": ""
},
{
"id": "C00008",
"database": "COMPOUND",
"url": ""
},
{
"id": "456216",
"database": "ChEBI",
"url": ""
},
{
"id": "000012360703",
"database": "ZINC",
"url": ""
}
]
},
{
"participant_id": "R-ALL-8931885",
"participant_name": "ATP [endoplasmic reticulum lumen]",
"crossref": [
{
"id": "30616",
"database": "ChEBI",
"url": ""
},
{
"id": "C00002",
"database": "COMPOUND",
"url": ""
},
{
"id": "000004261765",
"database": "ZINC",
"url": ""
},
{
"id": "C00002",
"database": "COMPOUND",
"url": ""
},
{
"id": "30616",
"database": "ChEBI",
"url": ""
},
{
"id": "000004261765",
"database": "ZINC",
"url": ""
},
{
"id": "C00002",
"database": "COMPOUND",
"url": ""
},
{
"id": "30616",
"database": "ChEBI",
"url": ""
},
{
"id": "000004261765",
"database": "ZINC",
"url": ""
},
{
"id": "000004261765",
"database": "ZINC",
"url": ""
},
{
"id": "C00002",
"database": "COMPOUND",
"url": ""
},
{
"id": "30616",
"database": "ChEBI",
"url": ""
},
{
"id": "30616",
"database": "ChEBI",
"url": ""
},
{
"id": "000004261765",
"database": "ZINC",
"url": ""
},
{
"id": "C00002",
"database": "COMPOUND",
"url": ""
}
]
},
{
"participant_id": "R-ALL-912516",
"participant_name": "Fe3+ [extracellular region]",
"crossref": [
{
"id": "29034",
"database": "ChEBI",
"url": ""
},
{
"id": "C14819",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0015531",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "C14819",
"database": "COMPOUND",
"url": ""
},
{
"id": "29034",
"database": "ChEBI",
"url": ""
},
{
"id": "HMDB0015531",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "29034",
"database": "ChEBI",
"url": ""
},
{
"id": "C14819",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0015531",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "HMDB0015531",
"database": "HMDB Metabolite",
"url": ""
},
{
"id": "29034",
"database": "ChEBI",
"url": ""
},
{
"id": "C14819",
"database": "COMPOUND",
"url": ""
},
{
"id": "29034",
"database": "ChEBI",
"url": ""
},
{
"id": "C14819",
"database": "COMPOUND",
"url": ""
},
{
"id": "HMDB0015531",
"database": "HMDB Metabolite",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "D3ZYW7",
"gene_name": "Fxn",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "D3ZYW7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZYW7"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "D3ZYW7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZYW7"
}
]
}
]
},
{
"uniprot_ac": "O00391",
"gene_name": "QSOX1",
"activity": [
{
"ec_number": "1.8.3.2",
"activity": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'.",
"evidence": [
{
"id": "O00391",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00391"
}
]
},
{
"ec_number": "1.8.3.2",
"activity": "",
"evidence": [
{
"id": "O00391",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00391"
}
]
}
]
},
{
"uniprot_ac": "O14672",
"gene_name": "ADAM10",
"activity": [
{
"ec_number": "3.4.24.81",
"activity": "Endopeptidase of broad specificity.",
"evidence": [
{
"id": "O14672",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14672"
}
]
},
{
"ec_number": "3.4.24.81",
"activity": "",
"evidence": [
{
"id": "O14672",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14672"
}
]
}
]
},
{
"uniprot_ac": "O35943",
"gene_name": "Fxn",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "O35943",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35943"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "O35943",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O35943"
}
]
}
]
},
{
"uniprot_ac": "O95084",
"gene_name": "PRSS23",
"activity": [
{
"ec_number": "3.4.21.-",
"activity": "",
"evidence": [
{
"id": "O95084",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O95084"
}
]
}
]
},
{
"uniprot_ac": "P00450",
"gene_name": "CP",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P00450",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00450"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P00450",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P00450"
}
]
}
]
},
{
"uniprot_ac": "P02794",
"gene_name": "FTH1",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P02794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02794"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P02794",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P02794"
}
]
}
]
},
{
"uniprot_ac": "P04070",
"gene_name": "PROC",
"activity": [
{
"ec_number": "3.4.21.69",
"activity": "Degradation of blood coagulation factors Va and VIIIa.",
"evidence": [
{
"id": "P04070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04070"
}
]
},
{
"ec_number": "3.4.21.69",
"activity": "",
"evidence": [
{
"id": "P04070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P04070"
}
]
}
]
},
{
"uniprot_ac": "P07237",
"gene_name": "P4HB",
"activity": [
{
"ec_number": "5.3.4.1",
"activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.",
"evidence": [
{
"id": "P07237",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07237"
}
]
},
{
"ec_number": "5.3.4.1",
"activity": "",
"evidence": [
{
"id": "P07237",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07237"
}
]
}
]
},
{
"uniprot_ac": "P09528",
"gene_name": "Fth1",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P09528",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09528"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P09528",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09528"
}
]
}
]
},
{
"uniprot_ac": "P13635",
"gene_name": "Cp",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P13635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13635"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P13635",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P13635"
}
]
}
]
},
{
"uniprot_ac": "P19132",
"gene_name": "Fth1",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "P19132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19132"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P19132",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P19132"
}
]
}
]
},
{
"uniprot_ac": "P38993",
"gene_name": "FET3",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
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{
"id": "P38993",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38993"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "P38993",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P38993"
}
]
}
]
},
{
"uniprot_ac": "Q07540",
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{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
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{
"id": "Q07540",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07540"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q07540",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q07540"
}
]
}
]
},
{
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{
"ec_number": "3.4.21.112",
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{
"id": "Q14703",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14703"
}
]
},
{
"ec_number": "3.4.21.112",
"activity": "",
"evidence": [
{
"id": "Q14703",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14703"
}
]
}
]
},
{
"uniprot_ac": "Q15084",
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{
"ec_number": "5.3.4.1",
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{
"id": "Q15084",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15084"
}
]
},
{
"ec_number": "5.3.4.1",
"activity": "",
"evidence": [
{
"id": "Q15084",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15084"
}
]
}
]
},
{
"uniprot_ac": "Q16595",
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"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
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{
"id": "Q16595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16595"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q16595",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q16595"
}
]
}
]
},
{
"uniprot_ac": "Q3V1H3",
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{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
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{
"id": "Q3V1H3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V1H3"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q3V1H3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q3V1H3"
}
]
}
]
},
{
"uniprot_ac": "Q54C45",
"gene_name": "fxn",
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{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
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{
"id": "Q54C45",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q54C45",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q54C45"
}
]
}
]
},
{
"uniprot_ac": "Q61147",
"gene_name": "Cp",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "Q61147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61147"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q61147",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q61147"
}
]
}
]
},
{
"uniprot_ac": "Q6MZM0",
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{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "Q6MZM0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6MZM0"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q6MZM0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6MZM0"
}
]
}
]
},
{
"uniprot_ac": "Q6P988",
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{
"ec_number": "3.1.1.98",
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"evidence": [
{
"id": "Q6P988",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P988"
}
]
},
{
"ec_number": "3.1.1.98",
"activity": "",
"evidence": [
{
"id": "Q6P988",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P988"
}
]
}
]
},
{
"uniprot_ac": "Q7KRU8",
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"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
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{
"id": "Q7KRU8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KRU8"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q7KRU8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q7KRU8"
}
]
}
]
},
{
"uniprot_ac": "Q8IXL6",
"gene_name": "FAM20C",
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{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "Q8IXL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IXL6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "Q8IXL6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8IXL6"
}
]
}
]
},
{
"uniprot_ac": "Q8N4E7",
"gene_name": "FTMT",
"activity": [
{
"ec_number": "1.16.3.1",
"activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.",
"evidence": [
{
"id": "Q8N4E7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N4E7"
}
]
},
{
"ec_number": "1.16.3.1",
"activity": "",
"evidence": [
{
"id": "Q8N4E7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8N4E7"
}
]
}
]
},
{
"uniprot_ac": "Q8NBP7",
"gene_name": "PCSK9",
"activity": [
{
"ec_number": "3.4.21.-",
"activity": "",
"evidence": [
{
"id": "Q8NBP7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8NBP7"
}
]
}
]
},
{
"uniprot_ac": "Q96AD5",
"gene_name": "PNPLA2",
"activity": [
{
"ec_number": "3.1.1.4",
"activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).",
"evidence": [
{
"id": "Q96AD5",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q96AD5"
}
]
},
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