{ "uniprot_canonical_ac": "P00352-1", "uniprot_ac": "P00352", "uniprot_id": "AL1A1_HUMAN", "mass": { "chemical_mass": 54862.0, "monoisotopic_mass": 54862.0 }, "refseq": { "ac": "NP_000680", "name": "aldehyde dehydrogenase 1A1", "summary": "The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" }, "gene_names": [ { "name": "ALDH1A1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P00352", "id": "P00352" }, { "name": "ALDC; ALDH-E1; ALDH1; ALDH11; HEL-9; HEL-S-53e; HEL12; PUMB1; RALDH1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680", "id": "NP_000680" }, { "name": "ALDC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P00352", "id": "P00352" }, { "name": "ALDH1A1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680", "id": "NP_000680" }, { "name": "ALDH1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P00352", "id": "P00352" }, { "name": "PUMB1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P00352", "id": "P00352" } ], "protein_names": [ { "name": "Aldehyde dehydrogenase 1A1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P00352" }, { "name": "1.2.1.19", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "1.2.1.28", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "1.2.1.36", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "1.2.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "3-deoxyglucosone dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "ALDH-E1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "ALHDII", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "Aldehyde dehydrogenase family 1 member A1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "Aldehyde dehydrogenase, cytosolic", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "RALDH 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "RalDH1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "Retinal dehydrogenase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00352" }, { "name": "aldehyde dehydrogenase 1A1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680", "id": "NP_000680" }, { "name": "retinaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; ALDH class 1; acetaldehyde dehydrogenase 1; retinal dehydrogenase 1; ALHDII; RALDH 1; epididymis luminal protein 12; epididymis secretory sperm binding protein Li 53e; epididymis luminal protein 9; 3-deoxyglucosone dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680", "id": "NP_000680" } ], "function": [ { "annotation": "ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" }, { "database": "PubMed", "id": "36552781", "url": "https://glygen.org/publication/PubMed/36552781" } ] }, { "annotation": "ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" }, { "database": "PubMed", "id": "38169509", "url": "https://glygen.org/publication/PubMed/38169509" } ] }, { "annotation": "Chromium (VI)-induced ALDH1A1/EGF axis promotes lung cancer progression.", "evidence": [ { "database": "RefSeq", "id": "NP_000680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" }, { "database": "PubMed", "id": "36504325", "url": "https://glygen.org/publication/PubMed/36504325" } ] }, { "annotation": "Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:19296407, PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:26373694, PubMed:25450233). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:19296407, PubMed:12941160, PubMed:15623782). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089). Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352#function" }, { "database": "PubMed", "id": "19296407", "url": "https://glygen.org/publication/PubMed/19296407" }, { "database": "PubMed", "id": "25450233", "url": "https://glygen.org/publication/PubMed/25450233" }, { "database": "PubMed", "id": "26373694", "url": "https://glygen.org/publication/PubMed/26373694" }, { "database": "PubMed", "id": "12941160", "url": "https://glygen.org/publication/PubMed/12941160" }, { "database": "PubMed", "id": "17175089", "url": "https://glygen.org/publication/PubMed/17175089" }, { "database": "PubMed", "id": "15623782", "url": "https://glygen.org/publication/PubMed/15623782" }, { "database": "UniProtKB", "id": "P24549", "url": "https://www.uniprot.org/uniprot/P24549#function" } ] }, { "annotation": "The Molecular Context of Oxidant Stress Response in Cancer Establishes ALDH1A1 as a Critical Target: What This Means for Acute Myeloid Leukemia. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" }, { "database": "PubMed", "id": "37298333", "url": "https://glygen.org/publication/PubMed/37298333" } ] }, { "annotation": "The Prognostic Value of Cancer Stem Cell Markers (CSCs) Expression-ALDH1A1, CD133, CD44-For Survival and Long-Term Follow-Up of Ovarian Cancer Patients. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" }, { "database": "PubMed", "id": "36768723", "url": "https://glygen.org/publication/PubMed/36768723" } ] }, { "annotation": "The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_000680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000680" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 302, "end_pos": 302, "sequence_org": "C", "sequence_mut": "A", "comment": "Does not prevent inhibition by duocarmycin analogs.", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" }, { "database": "PubMed", "id": "26373694", "url": "https://glygen.org/publication/PubMed/26373694" } ] }, { "start_pos": 302, "end_pos": 302, "sequence_org": "C", "sequence_mut": "S", "comment": "Does not prevent inhibition by duocarmycin analogs.", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" }, { "database": "PubMed", "id": "26373694", "url": "https://glygen.org/publication/PubMed/26373694" } ] }, { "start_pos": 458, "end_pos": 458, "sequence_org": "G", "sequence_mut": "N", "comment": "No significant effect on aldehyde dehydrogenase activity. Prevents the inhibition by ALDH1A1-specific inhibitors.", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" }, { "database": "PubMed", "id": "25634381", "url": "https://glygen.org/publication/PubMed/25634381" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "96.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "95.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "99.25", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "88.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "98.17", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "97.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "94.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "93.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "97.73", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "98.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "93.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "92.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000165092", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000165092" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "P00352", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00352" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": 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} ] } }, { "isoform_ac": "Q5SYQ7-1", "url": "", "sequence": { "sequence": "MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTAL", "length": 203, "header": "tr|Q5SYQ7-1|AL1A1_HUMAN Computationally mapped isoform of Aldehyde dehydrogenase 1A1 OS=Homo sapiens OX=9606 GN=ALDH1A1 PE=1 SV=1 CANONICAL=P00352-1" }, "locus": { "chromosome": "9", "start_pos": 72953000, "end_pos": 72925508, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000446946.1", "url": "https://www.ensembl.org/id/ENST00000446946.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000401361.1", "url": "https://www.ensembl.org/id/ENSP00000401361.1" } ] } }, { "isoform_ac": "Q5SYQ8-1", "url": "", "sequence": { "sequence": "MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD", "length": 238, "header": "tr|Q5SYQ8-1|AL1A1_HUMAN Computationally mapped isoform of Aldehyde dehydrogenase 1A1 OS=Homo sapiens OX=9606 GN=ALDH1A1 PE=1 SV=1 CANONICAL=P00352-1" }, "locus": { "chromosome": "9", "start_pos": 72953000, "end_pos": 72924052, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419959.5", "url": "https://www.ensembl.org/id/ENST00000419959.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000388026.1", "url": "https://www.ensembl.org/id/ENSP00000388026.1" } ] } }, { "isoform_ac": "Q5SYQ9-1", "url": "", "sequence": { "sequence": "MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGASVV", "length": 230, "header": "tr|Q5SYQ9-1|AL1A1_HUMAN Computationally mapped isoform of Aldehyde dehydrogenase 1A1 OS=Homo sapiens OX=9606 GN=ALDH1A1 PE=1 SV=1 CANONICAL=P00352-1" }, "locus": { "chromosome": "9", "start_pos": 72953000, "end_pos": 72917045, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376939.5", "url": "https://www.ensembl.org/id/ENST00000376939.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000366138.1", "url": "https://www.ensembl.org/id/ENSP00000366138.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P00352", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P00352" }, { "id": "30905621", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30905621" }, { "id": "18984734", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18984734" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" } ] } ], "phosphorylation": [ { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "PubMed", "id": "28193222", "url": "https://glygen.org/publication/PubMed/28193222" } ], "site_lbl": "Thr267" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser2" }, { "start_pos": 337, "end_pos": 337, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" } ], "site_lbl": "Thr337" }, { "start_pos": 360, "end_pos": 360, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser360" }, { "start_pos": 413, "end_pos": 413, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" } ], "site_lbl": "Ser413" }, { "start_pos": 442, "end_pos": 442, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" }, { "database": "PubMed", "id": "28193222", "url": "https://glygen.org/publication/PubMed/28193222" } ], "site_lbl": "Thr442" }, { "start_pos": 493, "end_pos": 493, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00352", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00352" }, { "database": "PubMed", "id": "28193222", "url": "https://glygen.org/publication/PubMed/28193222" } ], "site_lbl": "Thr493" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes.", "journal": "Molecular genetics and metabolism", "date": "1999", "authors": "Jurukovski V, Markova NG, Karaman-Jurukovska N, Randolph RK, Su J, Napoli JL, Simon M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "10329026", "url": "https://glygen.org/publication/PubMed/10329026" } ] }, { "title": "Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus.", "journal": "Nature genetics", "date": "1999", "authors": "Yamamoto H, Simon A, Eriksson U, Harris E, Berson EL, Dryja TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "10369264", "url": "https://glygen.org/publication/PubMed/10369264" } ] }, { "title": "Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.", "journal": "American journal of human genetics", "date": "1999", "authors": "Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10441588", "url": "https://glygen.org/publication/PubMed/10441588" } ] }, { "title": "Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.", "journal": "Protein science : a publication of the Protein Society", "date": "1999", "authors": "Ni L, Zhou J, Hurley TD, Weiner H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10631996", "url": "https://glygen.org/publication/PubMed/10631996" } ] }, { "title": "Regulation of the mammalian alcohol dehydrogenase genes.", "journal": "Progress in nucleic acid research and molecular biology", "date": "2000", "authors": "Edenberg HJ", "evidence": [ { "database": 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Biol.", "date": "1993", "authors": "Yoshida A, Hsu LC, Yanagawa Y", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" }, { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "8493914", "url": "https://glygen.org/publication/PubMed/8493914" } ] }, { "title": "Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene.", "journal": "Human mutation", "date": "1995", "authors": "Tolan DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-70350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70350" } ], "reference": [ { "type": "PubMed", "id": "8535439", "url": "https://glygen.org/publication/PubMed/8535439" } ] }, { "title": "X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Xie P, Parsons SH, Speckhard DC, Bosron WF, Hurley TD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "9228021", "url": "https://glygen.org/publication/PubMed/9228021" } ] }, { "title": "Hereditary fructose intolerance.", "journal": "Journal of medical genetics", "date": "1998", "authors": "Ali M, Rellos P, Cox TM", "evidence": [ { "database": "Reactome", "id": "R-HSA-70350", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70350" } ], "reference": [ { "type": "PubMed", "id": "9610797", "url": "https://glygen.org/publication/PubMed/9610797" } ] }, { "title": "cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Gough WH, VanOoteghem S, Sint T, Kedishvili NY", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "9677409", "url": "https://glygen.org/publication/PubMed/9677409" } ] }, { "title": "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5365859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859" } ], "reference": [ { "type": "PubMed", "id": "9705317", "url": "https://glygen.org/publication/PubMed/9705317" } ] }, { "title": "Human liver alcohol dehydrogenase: purification, composition, and catalytic features.", "journal": "Biochemistry", "date": "1976", "authors": "Lange LG, Sytkowski AJ, Vallee BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "9982", "url": "https://glygen.org/publication/PubMed/9982" } ] } ], "pathway": [ { "id": "hsa:216", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:216", "resource": "KEGG Pathway" }, { "id": "R-HSA-5365859", "name": "RA biosynthesis pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5365859", "resource": "Reactome", "description": "RA biosynthesis pathway" }, { "id": "R-HSA-70350", "name": "Fructose catabolism", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-70350", "resource": "Reactome", "description": "Fructose catabolism" }, { "id": "R-HSA-71384", "name": "Ethanol oxidation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384", "resource": "Reactome", "description": "Ethanol oxidation" } ], "orthologs": [ 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"name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "NAD binding", "id": "GO:0051287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051287", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "retinal dehydrogenase activity", "id": "GO:0001758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001758", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "aldehyde dehydrogenase (NAD+) activity", "id": "GO:0004029", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004029", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "androgen binding", "id": "GO:0005497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005497", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "benzaldehyde dehydrogenase (NAD+) activity", "id": "GO:0018479", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018479", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "aminobutyraldehyde dehydrogenase activity", "id": "GO:0019145", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019145", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "3-deoxyglucosone dehydrogenase activity", "id": "GO:0106373", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106373", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity", "id": "GO:0043878", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043878", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "retinoid metabolic process", "id": "GO:0001523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001523", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "cellular aldehyde metabolic process", "id": "GO:0006081", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006081", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "retinol metabolic process", "id": "GO:0042572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "maintenance of lens transparency", "id": "GO:0036438", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036438", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "gamma-aminobutyric acid biosynthetic process", "id": "GO:0009449", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009449", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "negative regulation of cold-induced thermogenesis", "id": "GO:0120163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120163", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "fructosamine catabolic process", "id": "GO:0030392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030392", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "cellular detoxification of aldehyde", "id": "GO:0110095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110095", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "P00352", "url": "https://www.uniprot.org/uniprot/P00352" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 389, "end_pos": 391, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11840", "name": "", "equation": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI42-1", "P51647-1", "P43353-1", "P00352-1", "Q80VQ0-1", "P24549-1" ], "evidence": [ { "id": "11840", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11840" } ] }, { "id": "16185", "name": "", "equation": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11884-1", "P11883-1", "P13601-1", "P30839-1", "Q66HF8-1", "Q5XI42-1", "Q64057-1", "Q9JLJ3-1", "P51647-1", "P48448-1", "P51648-1", "P49419-1", "P30837-1", "P05091-1", "P43353-1", "P30838-1", "P49189-1", "P00352-1", "P47738-1", "Q9CZS1-1", "O35945-1", "J3QMK6-1", "E9Q3E1-1", "P47740-1", "P47739-1", "Q80VQ0-1", "Q9DBF1-1", "Q9JLJ2-1", "P24549-1", "Q04458-1", "P47771-1", "P54114-1", "P83401-1", "Q54DG1-1" ], "evidence": [ { "id": "16185", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16185" } ] }, { "id": "19105", "name": "", "equation": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JLJ3-1", "P51647-1", "P49189-1", "P00352-1", "P24549-1", "Q9JLJ2-1" ], "evidence": [ { "id": "19105", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19105" } ] }, { "id": "25294", "name": "", "equation": "acetaldehyde + H2O + NAD(+) = acetate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "Q9JLJ3-1", "P00352-1", "P49189-1", "P24549-1", "Q9JLJ2-1" ], "evidence": [ { "id": "25294", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25294" } ] }, { "id": "42080", "name": "", "equation": "all-trans-retinal + H2O + NAD(+) = all-trans-retinoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "P51647-1", "Q8K4D8-1", "Q63639-1", "P00352-1", "P47895-1", "Q7Z5P4-1", "O94788-1", "P24549-1", "Q9JHW9-1", "Q8VCR2-1", "Q62148-1" ], "evidence": [ { "id": "42080", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42080" } ] }, { "id": "42084", "name": "", "equation": "9-cis-retinal + H2O + NAD(+) = 9-cis-retinoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "P00352-1", "P24549-1" ], "evidence": [ { "id": "42084", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/42084" } ] }, { "id": "47132", "name": "", "equation": "11-cis-retinal + H2O + NAD(+) = 11-cis-retinoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "P00352-1", "P24549-1" ], "evidence": [ { "id": "47132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47132" } ] }, { "id": "67244", "name": "", "equation": "3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "P00352-1", "P24549-1" ], "evidence": [ { "id": "67244", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67244" } ] }, { "id": "67248", "name": "", "equation": "(E)-4-hydroxynon-2-enal + H2O + NAD(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "Q64057-1", "P00352-1", "P49419-1", "P24549-1", "Q9DBF1-1" ], "evidence": [ { "id": "67248", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67248" } ] }, { "id": "67252", "name": "", "equation": "H2O + malonaldehyde + NAD(+) = 3-oxopropanoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "P00352-1", "P24549-1" ], "evidence": [ { "id": "67252", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67252" } ] }, { "id": "67256", "name": "", "equation": "H2O + NAD(+) + propanal = 2 H(+) + NADH + propanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "Q9JLJ3-1", "P00352-1", "P49189-1", "P24549-1", "Q9JLJ2-1", "P54115-1", "P40047-1", "P46367-1" ], "evidence": [ { "id": "67256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67256" } ] }, { "id": "67276", "name": "", "equation": "H2O + hexanal + NAD(+) = 2 H(+) + hexanoate + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "Q64057-1", "Q9JLJ3-1", "P00352-1", "P49419-1", "P49189-1", "P24549-1", "Q9DBF1-1", "Q9JLJ2-1" ], "evidence": [ { "id": "67276", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67276" } ] }, { "id": "67332", "name": "", "equation": "13-cis-retinal + H2O + NAD(+) = 13-cis-retinoate + 2 H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P51647-1", "P00352-1", "P24549-1" ], "evidence": [ { "id": "67332", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67332" } ] }, { "id": "R-HSA-5362522", "name": "ALDHs oxidise atRAL to atRA", "equation": "", "summary": "Several aldehyde dehydrogenases catalyse the irreversible oxidation of retinal to retinoic acid. ALDH1A1, 2 and 3 utilise NAD+ as cofactor to oxidise all-trans-retinal (atRAL) to all-trans-retinoic acid (atRA). They are cytosolic enzymes which are functional in their homotetrameric states (Yoshida et al. 1993, Duester 2008, Bchini et al. 2013).", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-975622" ], "output_participant_list": [ "R-ALL-5334816" ], "enzyme_list": [ "O94788-1", "P00352-1", "P47895-1" ], "evidence": [ { "id": "R-HSA-5362522", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5362522" } ] }, { "id": "R-HSA-6813749", "name": "ALDH1A1 oxidises GA to DGA", "equation": "", "summary": "Retinal dehydrogenase 1 (ALDH1A1 tetramer) is a cytosolic aldehyde dehydrogenase that can oxidise glyceraldehyde (GA) to D-glycerate (DGA) (Yoval-Sanchez et al. 2013). 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30838" } ] } ] }, { "uniprot_ac": "P30839", "gene_name": "Aldh3a2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] }, { "ec_number": "1.2.1.94", "activity": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH.", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] }, { "ec_number": "1.2.1.94", "activity": "", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P30839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30839" } ] } ] }, { "uniprot_ac": "P40047", "gene_name": "ALD5", "activity": [ { "ec_number": "1.2.1.-", "activity": "", 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"activity": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH.", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43353" } ] }, { "ec_number": "1.2.1.7", "activity": "", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43353" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43353" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "P43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43353" } ] } ] }, { "uniprot_ac": "P46367", "gene_name": "ALD4", "activity": [ { "ec_number": "1.2.1.-", "activity": "", "evidence": [ { "id": "P46367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46367" } ] }, { "ec_number": "1.2.1.4", "activity": "acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH.", "evidence": [ { "id": "P46367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46367" } ] }, { "ec_number": "1.2.1.4", "activity": "", "evidence": [ { "id": "P46367", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46367" } ] } ] }, { "uniprot_ac": "P47738", "gene_name": "Aldh2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P47738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47738" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P47738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47738" } ] } ] }, { "uniprot_ac": "P47739", "gene_name": "Aldh3a1", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P47739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47739" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "P47739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47739" } ] } ] }, { "uniprot_ac": "P47740", "gene_name": "Aldh3a2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P47740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47740" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P47740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47740" } ] }, { "ec_number": "1.2.1.94", "activity": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH.", "evidence": [ { "id": "P47740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47740" } ] }, { "ec_number": "1.2.1.94", "activity": "", "evidence": [ { "id": "P47740", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47740" } ] } ] }, { "uniprot_ac": "P47771", "gene_name": "ALD2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P47771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47771" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P47771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47771" } ] } ] }, { "uniprot_ac": "P47895", "gene_name": "ALDH1A3", "activity": [ { "ec_number": "1.2.1.36", "activity": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate.", "evidence": [ { "id": "P47895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47895" } ] }, { "ec_number": "1.2.1.36", "activity": "", "evidence": [ { "id": "P47895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47895" } ] } ] }, { "uniprot_ac": "P48448", "gene_name": "ALDH3B2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P48448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48448" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P48448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48448" } ] } ] }, { "uniprot_ac": "P49189", "gene_name": "ALDH9A1", "activity": [ { "ec_number": "1.2.1.19", "activity": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH.", "evidence": [ { "id": "P49189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49189" } ] }, { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P49189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49189" } ] }, { "ec_number": "1.2.1.47", "activity": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH.", "evidence": [ { "id": "P49189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49189" } ] }, { "ec_number": "1.2.1.46", "activity": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH.", "evidence": [ { "id": "P49189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49189" } ] }, { "ec_number": "1.2.1.47", "activity": "", "evidence": [ { "id": "P49189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49189" } ] } ] }, { "uniprot_ac": "P49419", "gene_name": "ALDH7A1", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P49419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49419" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P49419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49419" } ] }, { "ec_number": "1.2.1.31", "activity": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH.", "evidence": [ { "id": "P49419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49419" } ] }, { "ec_number": "1.2.1.8", "activity": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH.", "evidence": [ { "id": "P49419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49419" } ] }, { "ec_number": "1.2.1.31", "activity": "", "evidence": [ { "id": "P49419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49419" } ] } ] }, { "uniprot_ac": "P51647", "gene_name": "Aldh1a1", "activity": [ { "ec_number": "1.2.1.36", "activity": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate.", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.19", "activity": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH.", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.28", "activity": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH.", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.36", "activity": "", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] }, { "ec_number": "1.2.1.19", "activity": "", "evidence": [ { "id": "P51647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51647" } ] } ] }, { "uniprot_ac": "P51648", "gene_name": "ALDH3A2", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P51648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51648" } ] }, { "ec_number": "1.2.1.94", "activity": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH.", "evidence": [ { "id": "P51648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51648" } ] }, { "ec_number": "1.2.1.94", "activity": "", "evidence": [ { "id": "P51648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51648" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P51648", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51648" } ] } ] }, { "uniprot_ac": "P54114", "gene_name": "ALD3", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P54114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54114" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P54114", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54114" } ] } ] }, { "uniprot_ac": "P54115", "gene_name": "ALD6", "activity": [ { "ec_number": "1.2.1.-", "activity": "", "evidence": [ { "id": "P54115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54115" } ] }, { "ec_number": "1.2.1.4", "activity": "acetaldehyde + H2O + NADP(+) = acetate + 2 H(+) + NADPH.", "evidence": [ { "id": "P54115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54115" } ] }, { "ec_number": "1.2.1.4", "activity": "", "evidence": [ { "id": "P54115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54115" } ] } ] }, { "uniprot_ac": "P83401", "gene_name": "", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "P83401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83401" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "P83401", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83401" } ] } ] }, { "uniprot_ac": "Q04458", "gene_name": "HFD1", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q04458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04458" } ] }, { "ec_number": "1.2.1.64", "activity": "4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q04458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04458" } ] }, { "ec_number": "1.2.1.64", "activity": "", "evidence": [ { "id": "Q04458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04458" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "Q04458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04458" } ] } ] }, { "uniprot_ac": "Q54DG1", "gene_name": "comG", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q54DG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DG1" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "Q54DG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54DG1" } ] } ] }, { "uniprot_ac": "Q5M875", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] } ] }, { "uniprot_ac": "Q5XI42", "gene_name": "Aldh3b1", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.28", "activity": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.7", "activity": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH.", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.7", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "Q5XI42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI42" } ] } ] }, { "uniprot_ac": "Q62148", "gene_name": "Aldh1a2", "activity": [ { "ec_number": "1.2.1.36", "activity": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate.", "evidence": [ { "id": "Q62148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62148" } ] }, { "ec_number": "1.2.1.36", "activity": "", "evidence": [ { "id": "Q62148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62148" } ] } ] }, { "uniprot_ac": "Q63639", "gene_name": "Aldh1a2", "activity": [ { "ec_number": "1.2.1.36", "activity": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate.", "evidence": [ { "id": "Q63639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63639" } ] }, { "ec_number": "1.2.1.36", "activity": "", "evidence": [ { "id": "Q63639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63639" } ] } ] }, { "uniprot_ac": "Q64057", "gene_name": "Aldh7a1", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q64057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64057" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "Q64057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64057" } ] }, { "ec_number": "1.2.1.31", "activity": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH.", "evidence": [ { "id": "Q64057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64057" } ] }, { "ec_number": "1.2.1.8", "activity": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH.", "evidence": [ { "id": "Q64057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64057" } ] }, { "ec_number": "1.2.1.31", "activity": "", "evidence": [ { "id": "Q64057", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64057" } ] } ] }, { "uniprot_ac": "Q66HF8", "gene_name": "Aldh1b1", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q66HF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66HF8" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "Q66HF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66HF8" } ] } ] }, { "uniprot_ac": "Q7Z5P4", "gene_name": "HSD17B13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] } ] }, { "uniprot_ac": "Q80VQ0", "gene_name": "Aldh3b1", "activity": [ { "ec_number": "1.2.1.5", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q80VQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80VQ0" } ] }, { "ec_number": "1.2.1.28", "activity": "benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q80VQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80VQ0" } ] }, { "ec_number": "1.2.1.7", "activity": "benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH.", "evidence": [ { "id": "Q80VQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80VQ0" } ] }, { "ec_number": "1.2.1.7", "activity": "", "evidence": [ { "id": "Q80VQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80VQ0" } ] }, { "ec_number": "1.2.1.5", "activity": "", "evidence": [ { "id": "Q80VQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80VQ0" } ] }, { "ec_number": "1.2.1.28", "activity": "", "evidence": [ { "id": "Q80VQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80VQ0" } ] } ] }, { "uniprot_ac": "Q8K4D8", "gene_name": "Aldh1a3", "activity": [ { "ec_number": "1.2.1.36", "activity": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate.", "evidence": [ { "id": "Q8K4D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4D8" } ] }, { "ec_number": "1.2.1.36", "activity": "", "evidence": [ { "id": "Q8K4D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4D8" } ] } ] }, { "uniprot_ac": "Q8VCR2", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] } ] }, { "uniprot_ac": "Q9CZS1", "gene_name": "Aldh1b1", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q9CZS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZS1" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "Q9CZS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZS1" } ] } ] }, { "uniprot_ac": "Q9DBF1", "gene_name": "Aldh7a1", "activity": [ { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q9DBF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBF1" } ] }, { "ec_number": "1.2.1.31", "activity": "(S)-2-amino-6-oxohexanoate + H2O + NADP(+) = 2 H(+) + L-2-aminoadipate + NADPH.", "evidence": [ { "id": "Q9DBF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBF1" } ] }, { "ec_number": "1.2.1.8", "activity": "betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH.", "evidence": [ { "id": "Q9DBF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBF1" } ] }, { "ec_number": "1.2.1.31", "activity": "", "evidence": [ { "id": "Q9DBF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBF1" } ] }, { "ec_number": "1.2.1.3", "activity": "", "evidence": [ { "id": "Q9DBF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBF1" } ] } ] }, { "uniprot_ac": "Q9JHW9", "gene_name": "Aldh1a3", "activity": [ { "ec_number": "1.2.1.36", "activity": "H2O + NAD(+) + retinal = 2 H(+) + NADH + retinoate.", "evidence": [ { "id": "Q9JHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW9" } ] }, { "ec_number": "1.2.1.36", "activity": "", "evidence": [ { "id": "Q9JHW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW9" } ] } ] }, { "uniprot_ac": "Q9JLJ2", "gene_name": "Aldh9a1", "activity": [ { "ec_number": "1.2.1.19", "activity": "4-aminobutanal + H2O + NAD(+) = 4-aminobutanoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q9JLJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JLJ2" } ] }, { "ec_number": "1.2.1.3", "activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.", "evidence": [ { "id": "Q9JLJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JLJ2" } ] }, { "ec_number": "1.2.1.47", "activity": "4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH.", "evidence": [ { "id": "Q9JLJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JLJ2" } ] }, { "ec_number": "1.2.1.46", "activity": "formaldehyde + H2O + NAD(+) = formate + 2 H(+) + NADH.", "evidence": [ { "id": "Q9JLJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JLJ2" } ] }, { "ec_number": "1.2.1.47", "activity": "", "evidence": [ { "id": "Q9JLJ2", "database": "UniProtKB", "url": 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