{ "uniprot_canonical_ac": "P00325-1", "uniprot_ac": "P00325", "uniprot_id": "ADH1B_HUMAN", "mass": { "chemical_mass": 39835.0, "monoisotopic_mass": 39835.0 }, "refseq": { "ac": "NP_000659", "name": "all-trans-retinol dehydrogenase [NAD(+)] ADH1B isoform 1", "summary": "The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" }, "gene_names": [ { "name": "ADH1B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/P00325", "id": "P00325" }, { "name": "ADH1B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659", "id": "NP_000659" }, { "name": "ADH2; HEL-S-117", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659", "id": "NP_000659" }, { "name": "ADH2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/P00325", "id": "P00325" } ], "protein_names": [ { "name": "All-trans-retinol dehydrogenase [NAD(+)] ADH1B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "P00325" }, { "name": "1.1.1.105", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00325" }, { "name": "ADH, beta subunit; alcohol dehydrogenase 2 (class I), beta polypeptide; aldehyde reductase; alcohol dehydrogenase subunit beta; epididymis secretory protein Li 117; all-trans-retinol dehydrogenase [NAD(+)] ADH1B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659", "id": "NP_000659" }, { "name": "Alcohol dehydrogenase 1B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00325" }, { "name": "Alcohol dehydrogenase subunit beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "P00325" }, { "name": "all-trans-retinol dehydrogenase [NAD(+)] ADH1B isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659", "id": "NP_000659" } ], "function": [ { "annotation": "ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" }, { "database": "PubMed", "id": "37510297", "url": "https://glygen.org/publication/PubMed/37510297" } ] }, { "annotation": "Alcohol dehydrogenase-1B represses the proliferation, invasion and migration of breast cancer cells by inactivating the mitogen-activated protein kinase signalling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" }, { "database": "PubMed", "id": "38085522", "url": "https://glygen.org/publication/PubMed/38085522" } ] }, { "annotation": "Association of TOP2A and ADH1B with lipid levels and prognosis in patients with lung adenocarcinoma and squamous cell carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" }, { "database": "PubMed", "id": "37985446", "url": "https://glygen.org/publication/PubMed/37985446" } ] }, { "annotation": "Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820).", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325#function" }, { "database": "PubMed", "id": "16787387", "url": "https://glygen.org/publication/PubMed/16787387" }, { "database": "PubMed", "id": "15369820", "url": "https://glygen.org/publication/PubMed/15369820" } ] }, { "annotation": "Genetic influences on alcohol flushing in East Asian populations. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" }, { "database": "PubMed", "id": "37875790", "url": "https://glygen.org/publication/PubMed/37875790" } ] }, { "annotation": "Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" }, { "database": "PubMed", "id": "37795758", "url": "https://glygen.org/publication/PubMed/37795758" } ] }, { "annotation": "The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "90.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "81.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "97.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "93.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "99.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "98.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "93.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "99.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "98.5", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "99.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "82.65", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "97.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000196616", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000196616" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "P00325", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00325" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant 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"name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "P00325", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00325" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/P00325" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF", "length": 375, "header": "sp|P00325-1|ADH1B_HUMAN Isoform 1 of All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=3 CANONICAL=P00325-1" }, "isoforms": [ { "isoform_ac": "D6RHZ6-1", "url": "", "sequence": { "sequence": "MVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF", "length": 335, "header": "tr|D6RHZ6-1|ADH1B_HUMAN Computationally mapped isoform of All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=2 CANONICAL=P00325-1" }, "locus": { "chromosome": "4", "start_pos": 99318184, "end_pos": 99307843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000625860", "url": "https://www.ensembl.org/id/ENST00000625860" }, { "database": "Ensembl Peptide", "id": "ENSP00000486614", "url": "https://www.ensembl.org/id/ENSP00000486614" } ] } }, { "isoform_ac": "P00325-1", "url": "", "sequence": { "sequence": "MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF", "length": 375, "header": "sp|P00325-1|ADH1B_HUMAN Isoform 1 of All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=3 CANONICAL=P00325-1" }, "locus": { "chromosome": "4", "start_pos": 99321331, "end_pos": 99307843, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000305046.13", "url": "https://www.ensembl.org/id/ENST00000305046.13" }, { "database": "Ensembl Peptide", "id": "ENSP00000306606.8", "url": "https://www.ensembl.org/id/ENSP00000306606.8" } ] } }, { "isoform_ac": "P00325-2", "url": "", "sequence": { "sequence": "MVAVGICHTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF", "length": 335, "header": "sp|P00325-2|ADH1B_HUMAN Isoform 2 of All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=3 CANONICAL=P00325-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "P00325", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P00325" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "phosphorylation": [ { "start_pos": 23, "end_pos": 23, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P00325", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00325" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser23" }, { "start_pos": 342, "end_pos": 342, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00325", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00325" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser342" }, { "start_pos": 35, "end_pos": 35, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "P00325", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00325" } ], "site_lbl": "Tyr35" }, { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P00325", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00325" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser365" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism.", "journal": "American journal of human genetics", "date": "1999", "authors": "Chen CC, Lu RB, Chen YC, Wang MF, Chang YC, Li TK, Yin SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10441588", "url": "https://glygen.org/publication/PubMed/10441588" } ] }, { "title": "Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.", "journal": "Protein science : a publication of the Protein Society", "date": "1999", "authors": "Ni L, Zhou J, Hurley TD, Weiner H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10631996", "url": "https://glygen.org/publication/PubMed/10631996" } ] }, { "title": "Regulation of the mammalian alcohol dehydrogenase genes.", "journal": "Progress in nucleic acid research and molecular biology", "date": "2000", "authors": "Edenberg HJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10697413", "url": "https://glygen.org/publication/PubMed/10697413" } ] }, { "title": "Genetic polymorphism of alcohol dehydrogenase in Europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.", "journal": "Hepatology", "date": "2000", "authors": "Borras E, Coutelle C, Rosell A, Fernandez-Muixi F, Broch M, Crosas B, Hjelmqvist L, Lorenzo A, Gutierrez C, Santos M, Szczepanek M, Heilig M, Quattrocchi P, Farres J, Vidal F, Richart C, Mach T, Bogdal J, Jornvall H, Seitz HK, Couzigou P, Pares X", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "10733556", "url": "https://glygen.org/publication/PubMed/10733556" } ] }, { "title": "Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Luong A, Hannah VC, Brown MS, Goldstein JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "10843999", "url": "https://glygen.org/publication/PubMed/10843999" } ] }, { "title": "Three-dimensional structures of the three human class I alcohol dehydrogenases.", "journal": "Protein Sci.", "date": "2001", "authors": "Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "11274460", "url": "https://glygen.org/publication/PubMed/11274460" } ] }, { "title": "Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.", "journal": "Archives of biochemistry and biophysics", "date": "2004", "authors": "Martras S, Alvarez R, Gallego O, Dominguez M, de Lera AR, Farres J, Pares X", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "15369820", "url": "https://glygen.org/publication/PubMed/15369820" } ] }, { "title": "Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids.", "journal": "The Biochemical journal", "date": "2006", "authors": "Gallego O, Belyaeva OV, Porte S, Ruiz FX, Stetsenko AV, Shabrova EV, Kostereva NV, Farres J, Pares X, Kedishvili NY", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "16787387", "url": "https://glygen.org/publication/PubMed/16787387" } ] }, { "title": "Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "16788062", "url": "https://glygen.org/publication/PubMed/16788062" } ] }, { "title": "Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene.", "journal": "Biochemical and biophysical research communications", "date": "1991", "authors": "Chen CS, Yoshida A", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "1755855", "url": "https://glygen.org/publication/PubMed/1755855" } ] }, { "title": "Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.", "journal": "Biochimica et biophysica acta", "date": "1977", "authors": "Greenfield NJ, Pietruszko R", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "18196", "url": "https://glygen.org/publication/PubMed/18196" } ] }, { "title": "Structure of human beta 1 beta 1 alcohol dehydrogenase: catalytic effects of non-active-site substitutions.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1991", "authors": "Hurley TD, Bosron WF, Hamilton JA, Amzel LM", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "1896463", "url": "https://glygen.org/publication/PubMed/1896463" } ] }, { "title": "Purification and characterization of a new alcohol dehydrogenase from human stomach.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Moreno A, Pares X", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "1985938", "url": "https://glygen.org/publication/PubMed/1985938" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "P00325-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00325-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "2010", "authors": "Stagos D, Chen Y, Brocker C, Donald E, Jackson BC, Orlicky DJ, Thompson DC, Vasiliou V", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "20616185", "url": "https://glygen.org/publication/PubMed/20616185" } ] }, { "title": "Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.", "journal": "Biochimica et biophysica acta", "date": "1979", "authors": "Inoue K, Nishimukai H, Yamasawa K", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "224930", "url": "https://glygen.org/publication/PubMed/224930" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" }, { "database": "iPTMnet", "id": "P00325", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P00325" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "The genes for human alcohol dehydrogenases beta 1 and beta 2 differ by only one nucleotide.", "journal": "Eur. J. Biochem.", "date": "1989", "authors": "Matsuo Y, Yokoyama R, Yokoyama S", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "2547609", "url": "https://glygen.org/publication/PubMed/2547609" } ] }, { "title": "Nucleotide sequence of the ADH2(3) gene encoding the human alcohol dehydrogenase beta 3 subunit.", "journal": "Alcoholism, clinical and experimental research", "date": "1989", "authors": "Carr LG, Xu Y, Ho WH, Edenberg HJ", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "2679216", "url": "https://glygen.org/publication/PubMed/2679216" } ] }, { "title": "Isolation of pi-alcohol dehydrogenase of human liver: is it a determinant of alcoholism?", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1977", "authors": "Li TK, Bosron WF, Dafeldecker WP, Lange LG, Vallee BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "270680", "url": "https://glygen.org/publication/PubMed/270680" } ] }, { "title": "Molecular analysis of the human class I alcohol dehydrogenase gene family and nucleotide sequence of the gene encoding the beta subunit.", "journal": "J. Biol. Chem.", "date": "1986", "authors": "Duester G, Smith M, Bilanchone V, Hatfield G W", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "2935533", "url": "https://glygen.org/publication/PubMed/2935533" } ] }, { "title": "Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1986", "authors": "Ikuta T, Szeto S, Yoshida A", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "2935875", "url": "https://glygen.org/publication/PubMed/2935875" } ] }, { "title": "Molecular cloning of a full-length cDNA for human alcohol dehydrogenase.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1985", "authors": "Ikuta T, Fujiyoshi T, Kurachi K, Yoshida A", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "2986130", "url": "https://glygen.org/publication/PubMed/2986130" } ] }, { "title": "cDNA clones coding for the beta-subunit of human liver alcohol dehydrogenase have differently sized 3'-non-coding regions.", "journal": "FEBS Lett.", "date": "1986", "authors": "Hed\u00e9n L O, H\u00f6\u00f6g J O, Larsson K, Lake M, Lagerholm E, Holmgren A, Vallee B L, J\u00f6rnvall H, von Bahr-Lindstr\u00f6m H", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "3000832", "url": "https://glygen.org/publication/PubMed/3000832" } ] }, { "title": "Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenases.", "journal": "European journal of biochemistry", "date": "1988", "authors": "Julia P, Pares X, Jornvall H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "3278908", "url": "https://glygen.org/publication/PubMed/3278908" } ] }, { "title": "Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes.", "journal": "Biochemistry", "date": "1988", "authors": "Kaiser R, Holmquist B, Hempel J, Vallee BL, Jornvall H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "3365377", "url": "https://glygen.org/publication/PubMed/3365377" } ] }, { "title": "Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification.", "journal": "Genomics", "date": "1988", "authors": "Xu Y L, Carr L G, Bosron W F, Li T K, Edenberg H J", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "3397059", "url": "https://glygen.org/publication/PubMed/3397059" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "P00325", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=P00325" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "The human beta 3 alcohol dehydrogenase subunit differs from beta 1 by a Cys for Arg-369 substitution which decreases NAD(H) binding.", "journal": "Biochemical and biophysical research communications", "date": "1987", "authors": "Burnell JC, Carr LG, Dwulet FE, Edenberg HJ, Li TK, Bosron WF", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "3619918", "url": "https://glygen.org/publication/PubMed/3619918" } ] }, { "title": "ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder.", "journal": "Genes", "date": "2023-07-02", "authors": "Kukowka Arnold, Brzuchalski Bogus\u0142aw, Kurzawski Mateusz, Malinowski Damian, Bia\u0142ecka Monika Anna", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" } ], "reference": [ { "type": "PubMed", "id": "37510297", "url": "https://glygen.org/publication/PubMed/37510297" } ] }, { "title": "Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis.", "journal": "Cancer medicine", "date": "2023-10", "authors": "Zhang Biao, Peng Yu-Hui, Luo Yun, Hong Chao-Qun, Lin Yi-Wei, Zhang Yu-Ling, Xu Yi-Wei, Su Xue-Fen, Wu Fang-Cai", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" } ], "reference": [ { "type": "PubMed", "id": "37795758", "url": "https://glygen.org/publication/PubMed/37795758" } ] }, { "title": "Genetic influences on alcohol flushing in East Asian populations.", "journal": "BMC genomics", "date": "2023-10-24", "authors": "Cho Yoonsu, Lin Kuang, Lee Su-Hyun, Yu Canqing, Valle Dan Schmidt, Avery Daniel, Lv Jun, Jung Keumji, Li Liming, Smith George Davey, China Kadoorie Biobank Collaborative Group , Sun Dianjianyi, Chen Zhengming, Millwood Iona Y, Hemani Gibran, Walters Robin G", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" } ], "reference": [ { "type": "PubMed", "id": "37875790", "url": "https://glygen.org/publication/PubMed/37875790" } ] }, { "title": "Association of TOP2A and ADH1B with lipid levels and prognosis in patients with lung adenocarcinoma and squamous cell carcinoma.", "journal": "The clinical respiratory journal", "date": "2023-12", "authors": "Yin Dongdong, Zhang Yinci, Li Hui, Cheng Longqiang", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" } ], "reference": [ { "type": "PubMed", "id": "37985446", "url": "https://glygen.org/publication/PubMed/37985446" } ] }, { "title": "Alcohol dehydrogenase-1B represses the proliferation, invasion and migration of breast cancer cells by inactivating the mitogen-activated protein kinase signalling pathway.", "journal": "Journal of physiology and pharmacology : an official journal of the Polish Physiological Society", "date": "2023-10", "authors": "Jiang C, Liu R, Wu X", "evidence": [ { "database": "RefSeq", "id": "NP_000659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000659" } ], "reference": [ { "type": "PubMed", "id": "38085522", "url": "https://glygen.org/publication/PubMed/38085522" } ] }, { "title": "Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations.", "journal": "European journal of biochemistry", "date": "1985", "authors": "Hempel J, Kaiser R, Jornvall H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "4065146", "url": "https://glygen.org/publication/PubMed/4065146" } ] }, { "title": "Human liver pi-alcohol dehydrogenase: kinetic and molecular properties.", "journal": "Biochemistry", "date": "1979", "authors": "Bosron WF, Li TK, Dafeldecker WP, Vallee BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "427099", "url": "https://glygen.org/publication/PubMed/427099" } ] }, { "title": "Ontogenetic, polymorphic, and interethnic variation in the isoenzymes of human alcohol dehydrogenase.", "journal": "Annals of the New York Academy of Sciences", "date": "1972", "authors": "Murray RF Jr, Price PH", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "4504607", "url": "https://glygen.org/publication/PubMed/4504607" } ] }, { "title": "Studies on the subunit structure and molecular size of the human alcohol dehydrogenase isozymes determined by the different loci, ADH1, ADH2, and ADH3.", "journal": "Annals of human genetics", "date": "1973", "authors": "Smith M, Hopkinson DA, Harris H", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "4748759", "url": "https://glygen.org/publication/PubMed/4748759" } ] }, { "title": "Human liver alcohol dehydrogenase: amino acid substitution in the beta 2 beta 2 Oriental isozyme explains functional properties, establishes an active site structure, and parallels mutational exchanges in the yeast enzyme.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1984", "authors": "Jornvall H, Hempel J, Vallee BL, Bosron WF, Li TK", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "6374651", "url": "https://glygen.org/publication/PubMed/6374651" } ] }, { "title": "Human liver alcohol dehydrogenase. 1. The primary structure of the beta 1 beta 1 isoenzyme.", "journal": "European journal of biochemistry", "date": "1984", "authors": "Hempel J, Buhler R, Kaiser R, Holmquist B, de Zalenski C, von Wartburg JP, Vallee B, Jornvall H", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "6391920", "url": "https://glygen.org/publication/PubMed/6391920" } ] }, { "title": "Human liver alcohol dehydrogenase: purification and kinetic characterization of the beta 2 beta 2, beta 2 beta 1, alpha beta 2, and beta 2 gamma 1 `Oriental` isoenzymes.", "journal": "Biochemistry", "date": "1984", "authors": "Yin SJ, Bosron WF, Magnes LJ, Li TK", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "6395883", "url": "https://glygen.org/publication/PubMed/6395883" } ] }, { "title": "Molecular cloning of human class IV alcohol dehydrogenase cDNA.", "journal": "Biochemical and biophysical research communications", "date": "1994", "authors": "Yokoyama H, Baraona E, Lieber CS", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "8074657", "url": "https://glygen.org/publication/PubMed/8074657" } ] }, { "title": "Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.", "journal": "J. Mol. Biol.", "date": "1994", "authors": "Hurley T D, Bosron W F, Stone C L, Amzel L M", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "8201622", "url": "https://glygen.org/publication/PubMed/8201622" } ] }, { "title": "X-ray structure of human beta3beta3 alcohol dehydrogenase. The contribution of ionic interactions to coenzyme binding.", "journal": "J. Biol. Chem.", "date": "1996", "authors": "Davis G J, Bosron W F, Stone C L, Owusu-Dekyi K, Hurley T D", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "reference": [ { "type": "PubMed", "id": "8663387", "url": "https://glygen.org/publication/PubMed/8663387" } ] }, { "title": "Human liver alcohol dehydrogenase: purification, composition, and catalytic features.", "journal": "Biochemistry", "date": "1976", "authors": "Lange LG, Sytkowski AJ, Vallee BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-71384", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384" } ], "reference": [ { "type": "PubMed", "id": "9982", "url": "https://glygen.org/publication/PubMed/9982" } ] } ], "pathway": [ { "id": "hsa:125", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:125", "resource": "KEGG Pathway" }, { "id": "R-HSA-71384", "name": "Ethanol oxidation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71384", "resource": "Reactome", "description": "Ethanol oxidation" } ], "orthologs": [ { "uniprot_canonical_ac": "P00326-1", "protein_name": "Alcohol dehydrogenase 1C", "gene_name": "ADH1C", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGFDLLRSGKSIRTVLTF", "length": 375 }, "evidence": [ { "id": "45918184", "url": "http://www.informatics.jax.org/homology/45918184", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P00329-1", "protein_name": "Alcohol dehydrogenase 1", "gene_name": "Adh1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSTAGKVIKCKAAVLWELHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHVVSGTLVTPLPAVLGHEGAGIVESVGEGVTCVKPGDKVIPLFSPQCGECRICKHPESNFCSRSDLLMPRGTLREGTSRFSCKGKQIHNFISTSTFSQYTVVDDIAVAKIDGASPLDKVCLIGCGFSTGYGSAVKVAKVTPGSTCAVFGLGGVGLSVIIGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYSKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHAACGVSVVVGVPPNAQNLSMNPMLLLLGRTWKGAIFGGFKSKDSVPKLVADFMAKKFPLDPLITHVLPFEKINEAFDLLRSGKSIRTVLTF", "length": 375 }, "evidence": [ { "id": "45918184", "url": "http://www.informatics.jax.org/homology/45918184", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P06757-1", "protein_name": "Alcohol dehydrogenase 1", "gene_name": "Adh1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSTAGKVIKCKAAVLWEPHKPFTIEDIEVAPPKAHEVRIKMVATGVCRSDDHAVSGSLFTPLPAVLGHEGAGIVESIGEGVTCVKPGDKVIPLFSPQCGKCRICKHPESNLCCQTKNLTQPKGALLDGTSRFSCRGKPIHHFISTSTFSQYTVVDDIAVAKIDAAAPLDKVCLIGCGFSTGYGSAVQVAKVTPGSTCAVFGLGGVGLSVVIGCKTAGAAKIIAVDINKDKFAKAKELGATDCINPQDYTKPIQEVLQEMTDGGVDFSFEVIGRLDTMTSALLSCHSACGVSVIVGVPPSAQSLSVNPMSLLLGRTWKGAIFGGFKSKDAVPKLVADFMAKKFPLEPLITHVLPFEKINEAFDLLRAGKSIRTVLTF", "length": 376 }, "evidence": [ { "id": "45918184", "url": "http://www.informatics.jax.org/homology/45918184", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P07327-1", "protein_name": "Alcohol dehydrogenase 1A", "gene_name": "ADH1A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF", "length": 375 }, "evidence": [ { "id": "45918184", "url": "http://www.informatics.jax.org/homology/45918184", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "alcohol dehydrogenase activity, zinc-dependent", "id": "GO:0004024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004024", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "NAD-retinol dehydrogenase activity", "id": "GO:0004745", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004745", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "small molecule metabolic process", "id": "GO:0044281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044281", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "retinoid metabolic process", "id": "GO:0001523", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001523", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "ethanol oxidation", "id": "GO:0006069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006069", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "retinol metabolic process", "id": "GO:0042572", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042572", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" }, { "name": "retinoic acid metabolic process", "id": "GO:0042573", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042573", "evidence": [ { "database": "UniProtKB", "id": "P00325", "url": "https://www.uniprot.org/uniprot/P00325" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 301, "end_pos": 303, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21284", "name": "", "equation": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "Q64563-1", "Q8VD48-1", "P41682-1", "P50170-1", "O54753-1", "D3ZGP9-1", "P08319-1", "P40394-1", "P00325-1", "Q9BPW9-1", "O75452-1", "Q7Z5P4-1", "O14756-1", "A6NNS2-1", "Q64437-1", "Q9QYY9-1", "Q58NB6-1", "Q9R092-1", "Q8VCR2-1", "Q8CHS7-1" ], "evidence": [ { "id": "21284", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21284" } ] }, { "id": "55936", "name": "", "equation": "all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P41682-1", "P40394-1", "P00325-1", "Q64437-1" ], "evidence": [ { "id": "55936", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/55936" } ] }, { "id": "60632", "name": "", "equation": "all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P41682-1", "P40394-1", "P00325-1", "Q64437-1" ], "evidence": [ { "id": "60632", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/60632" } ] }, { "id": "R-HSA-71707", "name": "ethanol + NAD+ => acetaldehyde + NADH + H+", "equation": "", "summary": "Cytosolic alcohol dehydrogenase catalyzes the reaction of ethanol and NAD+ to form acetaldehyde and NADH + H+. The active form of the enzyme is a dimer with one zinc ion bound to each protein subunit. In the body, alcohol dehydrogenase is present in the liver, kidney, lung and gastric mucosa.

Six genes encode proteins active in ethanol oxidation: ADH1A, ADH1B, ADH1C, ADH4, ADH6, and ADH7 (Lange et al. 1976; Yin et al. 1985; Li et al. 1978; Bosron et al. 1979; Moreno and Pares 1991; Yokoyama et al. 1994; Chen and Yoshida 1991). ADH1A, B and C proteins can associate to form homodimers or heterodimers; ADH4, 6, and 7 proteins each form homodimers. Expression of ADH1A, B and C is developmentally regulated: ADH1A protein is abundant in the fetus, but expressed only at low levels in adulthood, when ADH1B and C proteins are abundant (Edenberg 2000). The various dimers differ substantially in the efficiency with which they oxidize ethanol. The ADH1B homodimer and heterodimers containing at least one 1B monomer are the most active towards ethanol (Yin et al. 1985). In addition, common polymorphic variants of ADH1B and C proteins differ substantially in this respect (Murray and Price 1972).", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-30203" ], "output_participant_list": [], "enzyme_list": [ "P08319-1", "P40394-1", "P00325-1", "P00326-1", "P07327-1", "P28332-1" ], "evidence": [ { "id": "R-HSA-71707", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-71707" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-30203", "participant_name": "EtOH [cytosol]", "crossref": [ { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { 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"" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "16236", "database": "ChEBI", "url": "" }, { "id": "HMDB0000108", "database": "HMDB Metabolite", "url": "" }, { "id": "2299", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145680", "database": "PubChem Substance", "url": "" }, { "id": "C00469", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A6NNS2", "gene_name": "DHRS7C", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "A6NNS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNS2" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "A6NNS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NNS2" } ] } ] }, { "uniprot_ac": "D3ZGP9", "gene_name": "Dhrs7c", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "D3ZGP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGP9" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "D3ZGP9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGP9" } ] } ] }, { "uniprot_ac": "O14756", "gene_name": "HSD17B6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] } ] }, { "uniprot_ac": "O54753", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] } ] }, { "uniprot_ac": "O75452", "gene_name": "RDH16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O75452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75452" } ] } ] }, { "uniprot_ac": "P00325", "gene_name": "ADH1B", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P00325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00325" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P00325", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00325" } ] } ] }, { "uniprot_ac": "P00326", "gene_name": "ADH1C", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P00326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00326" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P00326", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00326" } ] } ] }, { "uniprot_ac": "P07327", "gene_name": "ADH1A", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P07327", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07327" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P07327", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07327" } ] } ] }, { "uniprot_ac": "P08319", "gene_name": "ADH4", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P08319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08319" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P08319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08319" } ] } ] }, { "uniprot_ac": "P28332", "gene_name": "ADH6", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P28332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28332" } ] }, { "ec_number": "1.1.1.1", "activity": "", "evidence": [ { "id": "P28332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28332" } ] } ] }, { "uniprot_ac": "P40394", "gene_name": "ADH7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P40394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40394" } ] } ] }, { "uniprot_ac": "P41682", "gene_name": "Adh7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P41682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41682" } ] } ] }, { "uniprot_ac": "P50170", "gene_name": "Rdh16", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.315", "activity": "11-cis-retinol--[retinol-binding protein] + NAD(+) = 11-cis-retinal--[retinol-binding protein] + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] }, { "ec_number": "1.1.1.315", "activity": "", "evidence": [ { "id": "P50170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50170" } ] } ] }, { "uniprot_ac": "Q58NB6", "gene_name": "Dhrs9", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q58NB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q58NB6" } ] } ] }, { "uniprot_ac": "Q5M875", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] } ] }, { "uniprot_ac": "Q64437", "gene_name": "Adh7", "activity": [ { "ec_number": "1.1.1.1", "activity": "ethanol + NAD(+) = acetaldehyde + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.66", "activity": "10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH.", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q64437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64437" } ] } ] }, { "uniprot_ac": "Q64563", "gene_name": "Adh4", "activity": [ { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q64563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64563" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "Q64563", 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