{
    "uniprot_canonical_ac": "O96904-1",
    "uniprot_ac": "O96904",
    "uniprot_id": "TBC12_DICDI",
    "mass": {
        "chemical_mass": 50289.0,
        "monoisotopic_mass": 50289.0
    },
    "refseq": {
        "ac": "XP_646386",
        "name": "RabGAP/TBC domain-containing protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646386"
    },
    "gene_names": [
        {
            "name": "phgA",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/O96904",
            "id": "O96904"
        },
        {
            "name": "DDB_G0269130",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O96904",
            "id": "O96904"
        },
        {
            "name": "phgA",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646386",
            "id": "XP_646386"
        }
    ],
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            "name": "Drainin",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "O96904"
        },
        {
            "name": "RabGAP/TBC domain-containing protein",
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            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646386",
            "id": "XP_646386"
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        {
            "name": "TBC1 domain family member 12 homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O96904"
        }
    ],
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        {
            "annotation": "May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body.",
            "evidence": [
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                    "database": "UniProtKB",
                    "id": "O96904",
                    "url": "https://www.uniprot.org/uniprot/O96904#function"
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                {
                    "database": "PubMed",
                    "id": "15086784",
                    "url": "https://glygen.org/publication/PubMed/15086784"
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                {
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                    "id": "10369671",
                    "url": "https://glygen.org/publication/PubMed/10369671"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 275,
            "end_pos": 282,
            "sequence_org": "FLAAMFLL",
            "sequence_mut": "",
            "comment": "Impairs localization to the contractile vacuole and fusion of the contractile vacuole with the plasma membrane.",
            "evidence": [
                {
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                    "id": "O96904",
                    "url": "https://www.uniprot.org/uniprot/O96904"
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                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Dictyostelium discoideum",
            "taxid": 44689,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O96904",
                    "url": "https://www.uniprot.org/uniprot/O96904"
                }
            ],
            "common_name": "Cellular slime molds"
        }
    ],
    "gene": [
        {
            "name": "phgA",
            "url": "https://www.uniprot.org/uniprot/O96904",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "DDB_G0269130",
            "url": "http://dictybase.org/gene/DDB_G0269130",
            "database": "dictyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "8617341",
            "url": "https://www.ncbi.nlm.nih.gov/gene/8617341",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "O96904",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:O96904*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR000195",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035969",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ddi:DDB_G0269130",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0269130",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
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        },
        {
            "id": "KYLNAMD",
            "url": "https://omabrowser.org/oma/group/KYLNAMD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47219",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR47219:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47219:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00566",
            "url": "http://pfam.xfam.org/family/PF00566",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_O96904",
            "url": "http://purl.obolibrary.org/obo/PR_O96904",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "XP_646386",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_646386",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O96904",
            "url": "https://www.uniprot.org/uniprot/O96904",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O96904-1",
            "url": "https://www.uniprot.org/uniprot/O96904-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MICFDNSTAHTDSNNNNNQCDLPENYKELVTTGKVEKLILSPSSSLDRPKTLPPKSQEEVLKHQREYEEIQRKAKKTLEREAKEKEKLDAIRKEKERSLIDARKVWEEDIIPVWEKNSKKRDIKKIKDLSWRGLPPAVRGKIWRLCIGNDLRVTDELFNIFLGHANNAYNKTTSPPLKSSLSSSSKSPNINIDLRQANNSIHHSRSPMNTSTDGEDDVLDLETTNMALILQDIQDTFPSLMIFQKGGPLHSDLIDVLGAYICYRPDIGYVPGMTFLAAMFLLNMEKCDAFLSLSNHINSVCFLPFFRQDQSGIPKYLAAMDSTVEALTPPLHKHFKEIGISAKNYLVDWITTLFSKALPLDVATRIWDLVFIEGEIFIYRTALSILRYFISDLIQATYDECIDLFNKLPQRKISEDKLFEEIQSIVLDQRKFDKLLEK",
        "length": 438,
        "header": "sp|O96904-1|TBC12_DICDI Isoform 1 of Drainin  OS=Dictyostelium discoideum OX=44689 GN=phgA PE=1 SV=1 CANONICAL=O96904-1"
    },
    "isoforms": [
        {
            "isoform_ac": "O96904-1",
            "url": "",
            "sequence": {
                "sequence": "MICFDNSTAHTDSNNNNNQCDLPENYKELVTTGKVEKLILSPSSSLDRPKTLPPKSQEEVLKHQREYEEIQRKAKKTLEREAKEKEKLDAIRKEKERSLIDARKVWEEDIIPVWEKNSKKRDIKKIKDLSWRGLPPAVRGKIWRLCIGNDLRVTDELFNIFLGHANNAYNKTTSPPLKSSLSSSSKSPNINIDLRQANNSIHHSRSPMNTSTDGEDDVLDLETTNMALILQDIQDTFPSLMIFQKGGPLHSDLIDVLGAYICYRPDIGYVPGMTFLAAMFLLNMEKCDAFLSLSNHINSVCFLPFFRQDQSGIPKYLAAMDSTVEALTPPLHKHFKEIGISAKNYLVDWITTLFSKALPLDVATRIWDLVFIEGEIFIYRTALSILRYFISDLIQATYDECIDLFNKLPQRKISEDKLFEEIQSIVLDQRKFDKLLEK",
                "length": 438,
                "header": "sp|O96904-1|TBC12_DICDI Isoform 1 of Drainin  OS=Dictyostelium discoideum OX=44689 GN=phgA PE=1 SV=1 CANONICAL=O96904-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Drainin required for membrane fusion of the contractile vacuole in Dictyostelium is the prototype of a protein family also represented in man.",
            "journal": "The EMBO journal",
            "date": "1999-06-15",
            "authors": "Becker M, Matzner M, Gerisch G",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O96904",
                    "url": "https://www.uniprot.org/uniprot/O96904"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10369671",
                    "url": "https://glygen.org/publication/PubMed/10369671"
                }
            ]
        },
        {
            "title": "Structure-function analysis of the BEACH protein LvsA.",
            "journal": "Traffic (Copenhagen, Denmark)",
            "date": "2004-05",
            "authors": "Wu Wei-I, Yajnik Juhi, Siano Michael, De Lozanne Arturo",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O96904",
                    "url": "https://www.uniprot.org/uniprot/O96904"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15086784",
                    "url": "https://glygen.org/publication/PubMed/15086784"
                }
            ]
        },
        {
            "title": "The genome of the social amoeba Dictyostelium discoideum.",
            "journal": "Nature",
            "date": "2005",
            "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O96904",
                    "url": "https://www.uniprot.org/uniprot/O96904"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15875012",
                    "url": "https://glygen.org/publication/PubMed/15875012"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ddi:DDB_G0269130",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0269130",
            "resource": "KEGG Pathway"
        }
    ],
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            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "GTPase activator activity",
                        "id": "GO:0005096",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096",
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                                "id": "O96904",
                                "url": "https://www.uniprot.org/uniprot/O96904"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "small GTPase binding",
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                                "id": "O96904",
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                            }
                        ],
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                    }
                ]
            },
            {
                "name": "Biological Process",
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                    {
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                                "id": "O96904",
                                "url": "https://www.uniprot.org/uniprot/O96904"
                            }
                        ],
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                    },
                    {
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                                "id": "O96904",
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                        ],
                        "pmid": ""
                    },
                    {
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                    },
                    {
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                        ],
                        "pmid": ""
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                ]
            },
            {
                "name": "Cellular Component",
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                        "name": "contractile vacuole",
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                    },
                    {
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                        "pmid": ""
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            "end_pos": 172,
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    "reaction_participants": [],
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    "synthesized_glycans": [],
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