{ "uniprot_canonical_ac": "O95931-1", "uniprot_ac": "O95931", "uniprot_id": "CBX7_HUMAN", "mass": { "chemical_mass": 28341.0, "monoisotopic_mass": 28341.0 }, "refseq": { "ac": "NP_783640", "name": "chromobox protein homolog 7 isoform 1", "summary": "This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, "gene_names": [ { "name": "CBX7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95931", "id": "O95931" }, { "name": "CBX7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640", "id": "NP_783640" } ], "protein_names": [ { "name": "Chromobox protein homolog 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95931" }, { "name": "chromobox protein homolog 7 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640", "id": "NP_783640" }, { "name": "chromobox protein homolog 7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640", "id": "NP_783640" } ], "function": [ { "annotation": "Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, { "database": "PubMed", "id": "38037081", "url": "https://glygen.org/publication/PubMed/38037081" } ] }, { "annotation": "CBX7 is a chromobox protein causally linked to cancer development", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, { "database": "PubMed", "id": "17374722", "url": "https://glygen.org/publication/PubMed/17374722" } ] }, { "annotation": "CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, { "database": "PubMed", "id": "35526483", "url": "https://glygen.org/publication/PubMed/35526483" } ] }, { "annotation": "CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, { "database": "PubMed", "id": "34035231", "url": "https://glygen.org/publication/PubMed/34035231" } ] }, { "annotation": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931#function" }, { "database": "PubMed", "id": "19636380", "url": "https://glygen.org/publication/PubMed/19636380" }, { "database": "PubMed", "id": "21060834", "url": "https://glygen.org/publication/PubMed/21060834" }, { "database": "PubMed", "id": "21282530", "url": "https://glygen.org/publication/PubMed/21282530" }, { "database": "PubMed", "id": "21047797", "url": "https://glygen.org/publication/PubMed/21047797" } ] }, { "annotation": "Controls cellular lifespan through regulation of both the p16(Ink4a)/Rb and the Arf/p53 pathways Erratum:[Nat Cell Biol. 2022 Sep;24(9):1445. PMID: 35941232]", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, { "database": "PubMed", "id": "14647293", "url": "https://glygen.org/publication/PubMed/14647293" } ] }, { "annotation": "Expression and correlation analysis of Skp2 and CBX7 in cervical cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" }, { "database": "PubMed", "id": "34281957", "url": "https://glygen.org/publication/PubMed/34281957" } ] }, { "annotation": "This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 234, "end_pos": 234, "sequence_org": "F", "sequence_mut": "D", "comment": "Loss of interaction with RNF2.", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" }, { "database": "PubMed", "id": "20696397", "url": "https://glygen.org/publication/PubMed/20696397" } ] }, { "start_pos": 244, "end_pos": 244, "sequence_org": "F", "sequence_mut": "D", "comment": "Reduced interaction with RNF2.", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" }, { "database": "PubMed", "id": "20696397", "url": "https://glygen.org/publication/PubMed/20696397" } ] }, { "start_pos": 31, "end_pos": 31, "sequence_org": "K", "sequence_mut": "A", "comment": "Loss of cellular lifespan extension.", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" }, { "database": "PubMed", "id": "14647293", "url": "https://glygen.org/publication/PubMed/14647293" } ] }, { "start_pos": 32, "end_pos": 32, "sequence_org": "W", "sequence_mut": "A", "comment": "Loss of cellular lifespan extension.", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" }, { "database": "PubMed", "id": "14647293", "url": "https://glygen.org/publication/PubMed/14647293" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "88.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "81.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "96.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "96.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "86.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "89.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "95.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "90.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "81.68", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "94.42", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "90.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000100307", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000100307" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95931", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95931" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95931", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95931" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O95931", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95931" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O95931", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95931" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ 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This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O95931", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95931" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95931" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 251, "header": "sp|O95931-1|CBX7_HUMAN Isoform 1 of Chromobox protein homolog 7 OS=Homo sapiens OX=9606 GN=CBX7 PE=1 SV=1 CANONICAL=O95931-1" }, "isoforms": [ { "isoform_ac": "B0QYP2-1", "url": "", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 158, "header": "tr|B0QYP2-1|CBX7_HUMAN Computationally mapped isoform of Chromobox protein homolog 7 OS=Homo sapiens OX=9606 GN=CBX7 PE=1 SV=1 CANONICAL=O95931-1" }, "locus": { "chromosome": "22", "start_pos": 39152444, "end_pos": 39133894, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000401405.7", "url": "https://www.ensembl.org/id/ENST00000401405.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000384035.3", "url": "https://www.ensembl.org/id/ENSP00000384035.3" } ] } }, { "isoform_ac": "B0QYP3-1", "url": "", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPR", "length": 121, "header": "tr|B0QYP3-1|CBX7_HUMAN Computationally mapped isoform of Chromobox protein homolog 7 OS=Homo sapiens OX=9606 GN=CBX7 PE=1 SV=1 CANONICAL=O95931-1" }, "locus": { "chromosome": "22", "start_pos": 39152444, "end_pos": 39134570, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434260.1", "url": "https://www.ensembl.org/id/ENST00000434260.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000410896.1", "url": "https://www.ensembl.org/id/ENSP00000410896.1" } ] } }, { "isoform_ac": "O95931-1", "url": "", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF", "length": 251, "header": "sp|O95931-1|CBX7_HUMAN Isoform 1 of Chromobox protein homolog 7 OS=Homo sapiens OX=9606 GN=CBX7 PE=1 SV=1 CANONICAL=O95931-1" }, "locus": { "chromosome": "22", "start_pos": 39152444, "end_pos": 39133894, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000216133.10", "url": "https://www.ensembl.org/id/ENST00000216133.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000216133.5", "url": "https://www.ensembl.org/id/ENSP00000216133.5" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Polycomb CBX7 has a unifying role in cellular lifespan.", "journal": "Nature cell biology", "date": "2004", "authors": "Gil J, Bernard D, Martinez D, Beach D", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" }, { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ], "reference": [ { "type": "PubMed", "id": "14647293", "url": "https://glygen.org/publication/PubMed/14647293" } ] }, { "title": "Role of the chromobox protein CBX7 in lymphomagenesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martinez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ], "reference": [ { "type": "PubMed", "id": "17374722", "url": "https://glygen.org/publication/PubMed/17374722" } ] }, { "title": "Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.", "journal": "PloS one", "date": "2009", "authors": "Maertens GN, El Messaoudi-Aubert S, Racek T, Stock JK, Nicholls J, Rodriguez-Niedenfuhr M, Gil J, Peters G", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "reference": [ { "type": "PubMed", "id": "19636380", "url": "https://glygen.org/publication/PubMed/19636380" } ] }, { "title": "Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.", "journal": "Biochemistry", "date": "2009", "authors": "Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "reference": [ { "type": "PubMed", "id": "19791798", "url": "https://glygen.org/publication/PubMed/19791798" } ] }, { "title": "Polycomb group targeting through different binding partners of RING1B C-terminal domain.", "journal": "Structure (London, England : 1993)", "date": "2010", "authors": "Wang R, Taylor AB, Leal BZ, Chadwell LV, Ilangovan U, Robinson AK, Schirf V, Hart PJ, Lafer EM, Demeler B, Hinck AP, McEwen DG, Kim CA", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "reference": [ { "type": "PubMed", "id": "20696397", "url": "https://glygen.org/publication/PubMed/20696397" } ] }, { "title": "Recognition and specificity determinants of the human cbx chromodomains.", "journal": "The Journal of biological chemistry", "date": "2011-01-07", "authors": "Kaustov Lilia, Ouyang Hui, Amaya Maria, Lemak Alexander, Nady Nataliya, Duan Shili, Wasney Gregory A, Li Zhihong, Vedadi Masoud, Schapira Matthieu, Min Jinrong, Arrowsmith Cheryl H", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "reference": [ { "type": "PubMed", "id": "21047797", "url": "https://glygen.org/publication/PubMed/21047797" } ] }, { "title": "Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.", "journal": "PloS one", "date": "2010-10-29", "authors": "Li Qiang, Wang Xiuhong, Lu Zheming, Zhang Baozhen, Guan Zhenpo, Liu Zhaojun, Zhong Qiming, Gu Liankun, Zhou Jing, Zhu Budong, Ji Jiafu, Deng Dajun", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "reference": [ { "type": "PubMed", "id": "21060834", "url": "https://glygen.org/publication/PubMed/21060834" } ] }, { "title": "Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.", "journal": "Molecular & cellular proteomics : MCP", "date": "2011", "authors": "Vandamme J, Volkel P, Rosnoblet C, Le Faou P, Angrand PO", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "reference": [ { "type": "PubMed", "id": "21282530", "url": "https://glygen.org/publication/PubMed/21282530" } ] }, { "title": "CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling.", "journal": "Cell death & disease", "date": "2021", "authors": "Huang Z, Yan Y, Zhu Z, Liu J, He X, Dalangood S, Li M, Tan M, Cai J, Tang P, Huang R, Shen B, Yan J", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ], "reference": [ { "type": "PubMed", "id": "34035231", "url": "https://glygen.org/publication/PubMed/34035231" } ] }, { "title": "Expression and correlation analysis of Skp2 and CBX7 in cervical cancer.", "journal": "Journal of clinical pathology", "date": "2022-12", "authors": "Maimaitirexiati Gulikezi, Tian Ping, Maimaiti Hatimihan, Ding Lu, Ma Cailing, Li Yuting, Wang Jing, Yan Qi, Li Rong", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ], "reference": [ { "type": "PubMed", "id": "34281957", "url": "https://glygen.org/publication/PubMed/34281957" } ] }, { "title": "CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.", "journal": "Biochemical and biophysical research communications", "date": "2022", "authors": "Ren W, Ren J, Zhang N, Liu X, Deng Y, Jiang Y, Yan B, Xiao X, Yu H", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ], "reference": [ { "type": "PubMed", "id": "35526483", "url": "https://glygen.org/publication/PubMed/35526483" } ] }, { "title": "Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells.", "journal": "Journal of ovarian research", "date": "2023-11-30", "authors": "Zhang Yi, Tedja Roslyn, Millman Michael, Wong Terrence, Fox Alexandra, Chehade Hussein, Gershater Meyer, Adzibolosu Nicholas, Gogoi Radhika, Anderson Matthew, Rutherford Thomas, Zhang Zhenggang, Chopp Michael, Mor Gil, Alvero Ayesha B", "evidence": [ { "database": "RefSeq", "id": "NP_783640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783640" } ], "reference": [ { "type": "PubMed", "id": "38037081", "url": "https://glygen.org/publication/PubMed/38037081" } ] } ], "pathway": [ { "id": "hsa:23492", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23492", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1SNY1-1", "protein_name": "Chromobox protein homolog 7 isoform 1", "gene_name": "CBX7", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLARPLGSGSPEGVVKAGAPELADKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQESPAPDVLQAASEWEPAEQPPEEEADADLAEGPPSWTPTLPSSEVTVTDITANSITVTFREAQAAEGFFRDRGGKF", "length": 251 }, "evidence": [ { "id": "O95931", "url": "https://omabrowser.org/oma/group/O95931/", "database": "OMA" } ], "common_name": "Pig" }, { "uniprot_canonical_ac": "P60889-1", "protein_name": "Chromobox protein homolog 7", "gene_name": "Cbx7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLLLQESAAPDVLQATGDWEPVEQPPEEEAEADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRSGKL", "length": 158 }, "evidence": [ { "id": "45926141", "url": "http://www.informatics.jax.org/homology/45926141", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VDS3-1", "protein_name": "Chromobox protein homolog 7", "gene_name": "Cbx7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPRRLLLQESAAPDVVQTPGDWEPMEQAPEEEAEADLTNGPPPWTPTLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRNEKL", "length": 158 }, "evidence": [ { "id": "45926141", "url": "http://www.informatics.jax.org/homology/45926141", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "PRC1 complex", "id": "GO:0035102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035102", "evidence": [ { "database": "UniProtKB", "id": "O95931", "url": "https://www.uniprot.org/uniprot/O95931" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": 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