{ "uniprot_canonical_ac": "O95881-1", "uniprot_ac": "O95881", "uniprot_id": "TXD12_HUMAN", "mass": { "chemical_mass": 19206.0, "monoisotopic_mass": 19206.0 }, "refseq": { "ac": "NP_056997", "name": "thioredoxin domain-containing protein 12 precursor", "summary": "This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, "gene_names": [ { "name": "TXNDC12", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95881", "id": "O95881" }, { "name": "AG1; AGR1; ERP16; ERP18; ERP19; hAG-1; hTLP19; PDIA16; TLP19", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997", "id": "NP_056997" }, { "name": "PRO1376", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95881", "id": "O95881" }, { "name": "TLP19", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95881", "id": "O95881" }, { "name": "TXNDC12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997", "id": "NP_056997" } ], "protein_names": [ { "name": "Thioredoxin domain-containing protein 12", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95881" }, { "name": "1.8.4.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "ER protein 18", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "ER protein 19", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "ERp18", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "ERp19", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "Endoplasmic reticulum resident protein 18", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "Endoplasmic reticulum resident protein 19", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "Thioredoxin-like protein p19", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "hTLP19", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95881" }, { "name": "thioredoxin domain-containing protein 12 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997", "id": "NP_056997" }, { "name": "thioredoxin-like protein p19; endoplasmic reticulum thioredoxin superfamily member, 18 kDa; protein disulfide isomerase family A, member 16; anterior gradient homolog 1; thioredoxin domain-containing protein 12; endoplasmic reticulum protein ERp19; ER protein 18; ER protein 19; endoplasmic reticulum resident protein 18; endoplasmic reticulum resident protein 19; thioredoxin domain containing 12 (endoplasmic reticulum)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997", "id": "NP_056997" } ], "function": [ { "annotation": "Clinical Value of TXNDC12 Combined With IDH and 1p19q as Biomarkers for Prognosis of Glioma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, { "database": "PubMed", "id": "34629960", "url": "https://glygen.org/publication/PubMed/34629960" } ] }, { "annotation": "Data demonstrate that ERp18 monitors ATF6a endoplasmic reticulum quality control to ensure optimal processing following trafficking to the Golgi.", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, { "database": "PubMed", "id": "31368601", "url": "https://glygen.org/publication/PubMed/31368601" } ] }, { "annotation": "ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, { "database": "PubMed", "id": "18628206", "url": "https://glygen.org/publication/PubMed/18628206" } ] }, { "annotation": "Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881#function" }, { "database": "PubMed", "id": "12761212", "url": "https://glygen.org/publication/PubMed/12761212" } ] }, { "annotation": "Putative physiological role for endoplasmic reticulum thioredoxin superfamily member p18(ERp18) in native disulfide bond formation is discussed", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, { "database": "PubMed", "id": "12761212", "url": "https://glygen.org/publication/PubMed/12761212" } ] }, { "annotation": "TXNDC12 promotes EMT and metastasis of hepatocellular carcinoma cells via activation of beta-catenin.", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, { "database": "PubMed", "id": "31570854", "url": "https://glygen.org/publication/PubMed/31570854" } ] }, { "annotation": "The solution structure of oxidized ERp18 as determined using NMR spectroscopy", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" }, { "database": "PubMed", "id": "19361226", "url": "https://glygen.org/publication/PubMed/19361226" } ] }, { "annotation": "This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1237516547", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1237516547" }, { "id": "rs1237516547", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1237516547#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 134, "end_pos": 134, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGN->NGS).", "chr_id": "1", "chr_pos": "52023529", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N134", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs754723918", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs754723918" }, { "id": "rs754723918", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs754723918" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 135, "end_pos": 135, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NSS).", "chr_id": "1", "chr_pos": "52023527", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P135", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95881", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95881" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 136, "end_pos": 136, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->I).", "chr_id": "1", "chr_pos": "52023523", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S136", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs756170758", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756170758" }, { "id": "rs756170758", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756170758" }, { "id": "rs756170758", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs756170758#frequency_tab" }, { "id": "rs756170758", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756170758" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 136, "end_pos": 136, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->N).", "chr_id": "1", "chr_pos": "52023523", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S136", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95881", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95881" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 62, "end_pos": 62, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "H", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (HKS->NKS).", "chr_id": "1", "chr_pos": "52028605", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "H62", "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 66, "end_pos": 66, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of protein-disulfide reductase (glutathione) activity. Loss of the formation of disulfide bonds in substrate.", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" }, { "database": "PubMed", "id": "12761212", "url": "https://glygen.org/publication/PubMed/12761212" } ] }, { "start_pos": 69, "end_pos": 69, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of protein-disulfide reductase (glutathione) activity. Loss of the formation of disulfide bonds in substrate.", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" }, { "database": "PubMed", "id": "12761212", "url": "https://glygen.org/publication/PubMed/12761212" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "91.13", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "92.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "90.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "91.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "94.17", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "90.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "90.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "90.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "89.08", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "90.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95881", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95881" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", 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"Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": 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"https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"BioXpress", "id": "O95881", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95881" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95881" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" } ], "common_name": "Human" } ], "gene": [ { "name": "TXNDC12", "url": "https://www.uniprot.org/uniprot/O95881", "locus": { "chromosome": "1", "start_pos": 52020131, "end_pos": 52055191, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000117862", "url": "https://www.ensembl.org/id/ENSG00000117862" } ] } } ], "crossref": [ { "id": "ENSG00000117862", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000117862", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O95881", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95881", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd02959", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02959", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "TXNDC12", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TXNDC12", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "51060", "url": "https://www.ncbi.nlm.nih.gov/gene/51060", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "24626", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24626", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O95881", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95881*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR013766", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013766", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017937", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017937", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036249", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036249", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037462", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037462", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:51060", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:51060", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "609448", "url": "http://www.omim.org/entry/609448", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O95881", "url": "https://www.nextprot.org/entry/NX_O95881", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O95881", "url": "https://oglcnac.org/atlas/detail/O95881", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O95881", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95881", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "DIAWVKW", "url": "https://omabrowser.org/oma/group/DIAWVKW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "101767at2759", "url": "http://www.orthodb.org/?query=101767at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15337", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15337", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15337:SF10", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15337:SF10", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1SEN", "url": "https://www.rcsb.org/structure/1SEN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2K8V", "url": "https://www.rcsb.org/structure/2K8V", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF13899", "url": "http://pfam.xfam.org/family/PF13899", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95881", "url": "https://pharos.nih.gov/targets/O95881", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95881", "url": "http://purl.obolibrary.org/obo/PR_O95881", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "21064", "url": "https://www.rhea-db.org/rhea/21064", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95881-1", "url": "https://www.uniprot.org/uniprot/O95881-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GY50", "url": "https://www.uniprot.org/uniprot/V9GY50", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GY50-1", "url": "https://www.uniprot.org/uniprot/V9GY50-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYV4", "url": "https://www.uniprot.org/uniprot/V9GYV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "V9GYV4-1", "url": "https://www.uniprot.org/uniprot/V9GYV4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL", "length": 172, "header": "sp|O95881-1|TXD12_HUMAN Isoform 1 of Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1 CANONICAL=O95881-1" }, "isoforms": [ { "isoform_ac": "O95881-1", "url": "", "sequence": { "sequence": "METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL", "length": 172, "header": "sp|O95881-1|TXD12_HUMAN Isoform 1 of Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1 CANONICAL=O95881-1" }, "locus": { "chromosome": "1", "start_pos": 52055096, "end_pos": 52020936, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000371626.9", "url": "https://www.ensembl.org/id/ENST00000371626.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000360688.4", "url": "https://www.ensembl.org/id/ENSP00000360688.4" } ] } }, { "isoform_ac": "V9GY50-1", "url": "", "sequence": { "sequence": "METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAARPY", "length": 55, "header": "tr|V9GY50-1|V9GY50_HUMAN Computationally mapped isoform of Thioredoxin domain containing 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1 CANONICAL=O95881-1" }, "locus": { "chromosome": "1", "start_pos": 52055096, "end_pos": 52034045, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000610127.2", "url": "https://www.ensembl.org/id/ENST00000610127.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000476401.1", "url": "https://www.ensembl.org/id/ENSP00000476401.1" } ] } }, { "isoform_ac": "V9GYV4-1", "url": "", "sequence": { "sequence": "METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAARIHV", "length": 56, "header": "tr|V9GYV4-1|V9GYV4_HUMAN Computationally mapped isoform of Thioredoxin domain containing 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1 CANONICAL=O95881-1" }, "locus": { "chromosome": "1", "start_pos": 52055096, "end_pos": 52030539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000472624.5", "url": "https://www.ensembl.org/id/ENST00000472624.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000477120.1", "url": "https://www.ensembl.org/id/ENSP00000477120.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 136, "start_aa": "Ser", "end_pos": 136, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser136", "evidence": [ { "id": "O95881", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95881" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "21740066", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21740066" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "O95881", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95881" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 136, "start_aa": "Ser", "end_pos": 136, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser136", "evidence": [ { "id": "GLY_000142", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000142" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Alanen HI, Williamson RA, Howard MJ, Lappi AK, Jantti HP, Rautio SM, Kellokumpu S, Ruddock LW", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" }, { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" } ], "reference": [ { "type": "PubMed", "id": "12761212", "url": "https://glygen.org/publication/PubMed/12761212" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein.", "journal": "Gene", "date": "2003", "authors": "Liu F, Rong YP, Zeng LC, Zhang X, Han ZG", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" } ], "reference": [ { "type": "PubMed", "id": "14557066", "url": "https://glygen.org/publication/PubMed/14557066" } ] }, { "title": "Signal peptide prediction based on analysis of experimentally verified cleavage sites.", "journal": "Protein Sci.", "date": "2004", "authors": "Zhang Z, Henzel WJ", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" } ], "reference": [ { "type": "PubMed", "id": "15340161", "url": "https://glygen.org/publication/PubMed/15340161" } ] }, { "title": "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.", "journal": "DNA Res.", "date": "2005", "authors": "Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" } ], "reference": [ { "type": "PubMed", "id": "16303743", "url": "https://glygen.org/publication/PubMed/16303743" } ] }, { "title": "ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Jeong W, Lee DY, Park S, Rhee SG", "evidence": [ { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" } ], "reference": [ { "type": "PubMed", "id": "18628206", "url": "https://glygen.org/publication/PubMed/18628206" } ] }, { "title": "Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase .", "journal": "Biochemistry", "date": "2009", "authors": "Rowe ML, Ruddock LW, Kelly G, Schmidt JM, Williamson RA, Howard MJ", "evidence": [ { "database": "UniProtKB", "id": "O95881", "url": "https://www.uniprot.org/uniprot/O95881" }, { "database": "RefSeq", "id": "NP_056997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056997" } ], "reference": [ { "type": "PubMed", "id": "19361226", "url": "https://glygen.org/publication/PubMed/19361226" } ] }, { "title": "Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment.", "journal": "Journal of proteome research", "date": "2011", "authors": "Zhao P, Viner R, Teo CF, Boons GJ, Horn D, Wells L", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95881", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95881" } ], "reference": [ { "type": "PubMed", "id": "21740066", "url": "https://glygen.org/publication/PubMed/21740066" } ] }, { "title": "Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2018", "authors": "Qin W, Qin K, Fan X, Peng L, Hong W, Zhu Y, Lv P, Du Y, Huang R, Han M, Cheng B, Liu Y, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95881", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95881" } ], "reference": [ { "type": "PubMed", "id": "29237092", "url": "https://glygen.org/publication/PubMed/29237092" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", 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