{ "uniprot_canonical_ac": "O95872-1", "uniprot_ac": "O95872", "uniprot_id": "GPAN1_HUMAN", "mass": { "chemical_mass": 39314.0, "monoisotopic_mass": 39314.0 }, "refseq": { "ac": "NP_001186166", "name": "G patch domain and ankyrin repeat-containing protein 1", "summary": "This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166" }, "gene_names": [ { "name": "GPANK1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95872", "id": "O95872" }, { "name": "ANKRD59; BAT4; D6S54E; G5; GPATCH10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166", "id": "NP_001186166" }, { "name": "ANKRD59", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95872", "id": "O95872" }, { "name": "BAT4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95872", "id": "O95872" }, { "name": "G5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95872", "id": "O95872" }, { "name": "GPANK1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166", "id": "NP_001186166" }, { "name": "GPATCH10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95872", "id": "O95872" } ], "protein_names": [ { "name": "G patch domain and ankyrin repeat-containing protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95872" }, { "name": "Ankyrin repeat domain-containing protein 59", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95872" }, { "name": "G patch domain and ankyrin repeat-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166", "id": "NP_001186166" }, { "name": "G patch domain containing 10; protein BAT4; G patch domain and ankyrin repeats-containing protein 1; protein G5; HLA-B-associated transcript 4; g patch domain-containing protein 10; ankyrin repeat domain-containing protein 59", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166", "id": "NP_001186166" }, { "name": "G patch domain-containing protein 10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95872" }, { "name": "HLA-B-associated transcript 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95872" }, { "name": "Protein G5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95872" } ], "function": [ { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001186166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166" }, { "database": "PubMed", "id": "18835879", "url": "https://glygen.org/publication/PubMed/18835879" } ] }, { "annotation": "This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001186166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "83.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "83.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "86.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "85.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "84.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "86.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "84.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "81.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "84.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "84.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204438", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204438" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95872", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95872" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O95872", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95872" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95872", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95872" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95872" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O95872", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95872" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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OX=9606 GN=GPANK1 PE=1 SV=6 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 2969525, "end_pos": 2969034, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000412886.5", "url": "https://www.ensembl.org/id/ENST00000412886.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000401352.1", "url": "https://www.ensembl.org/id/ENSP00000401352.1" } ] } }, { "isoform_ac": "A0A0A0MSL5-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGAS", "length": 89, "header": "tr|A0A0A0MSL5-1|GPAN1_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=6 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 2969525, "end_pos": 2969259, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442498.1", "url": "https://www.ensembl.org/id/ENST00000442498.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000404929.1", "url": "https://www.ensembl.org/id/ENSP00000404929.1" } ] } }, { "isoform_ac": "A0A0G2JHL1-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYCENCDTHFQDSNHRTSTAHLLSLSQGPQPPNLPLGVPISSPGFKLLLRRGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRSAPQPRVTHFPAWDTRAVAGRERPPRVATLSWREERRREEKDRAWERDLRTYMNLEF", "length": 356, "header": "tr|A0A0G2JHL1-1|GPAN1_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_DBB_CTG1", "start_pos": 2912249, "end_pos": 2910040, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000419261.5", "url": "https://www.ensembl.org/id/ENST00000419261.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000388586.1", "url": "https://www.ensembl.org/id/ENSP00000388586.1" } ] } }, { "isoform_ac": "A0A0G2JHT6-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHR", "length": 107, "header": "tr|A0A0G2JHT6-1|GPAN1_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 3006350, "end_pos": 3006030, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000418144.1", "url": "https://www.ensembl.org/id/ENST00000418144.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000392449.1", "url": "https://www.ensembl.org/id/ENSP00000392449.1" } ] } }, { "isoform_ac": "A0A0G2JJ08-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAALAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHR", "length": 107, "header": "tr|A0A0G2JJ08-1|A0A0G2JJ08_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_COX_CTG1", "start_pos": 3141769, "end_pos": 3141449, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440952.1", "url": "https://www.ensembl.org/id/ENST00000440952.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000403719.1", "url": "https://www.ensembl.org/id/ENSP00000403719.1" } ] } }, { "isoform_ac": "A0A0G2JJ73-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAALAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLG", "length": 164, "header": "tr|A0A0G2JJ73-1|A0A0G2JJ73_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=4 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2920302, "end_pos": 2919811, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000415610.5", "url": "https://www.ensembl.org/id/ENST00000415610.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000415884.1", "url": "https://www.ensembl.org/id/ENSP00000415884.1" } ] } }, { "isoform_ac": "A0A0G2JJI2-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAALAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGAS", "length": 89, "header": "tr|A0A0G2JJI2-1|A0A0G2JJI2_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=4 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_SSTO_CTG1", "start_pos": 2963762, "end_pos": 2963496, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416364.1", "url": "https://www.ensembl.org/id/ENST00000416364.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000398758.1", "url": "https://www.ensembl.org/id/ENSP00000398758.1" } ] } }, { "isoform_ac": "A0A0G2JK30-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRE", "length": 198, "header": "tr|A0A0G2JK30-1|GPAN1_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 3006350, "end_pos": 3005757, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000423574.5", "url": "https://www.ensembl.org/id/ENST00000423574.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000387492.1", "url": "https://www.ensembl.org/id/ENSP00000387492.1" } ] } }, { "isoform_ac": "A0A0G2JK37-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAALAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRE", "length": 198, "header": "tr|A0A0G2JK37-1|GPAN1_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_SSTO_CTG1", "start_pos": 2963762, "end_pos": 2963169, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000424956.5", "url": "https://www.ensembl.org/id/ENST00000424956.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000413683.1", "url": "https://www.ensembl.org/id/ENSP00000413683.1" } ] } }, { "isoform_ac": "A0A0G2JKD0-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAALAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAAR", "length": 152, "header": "tr|A0A0G2JKD0-1|GPAN1_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2920302, "end_pos": 2919847, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414010.5", "url": "https://www.ensembl.org/id/ENST00000414010.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000416056.1", "url": "https://www.ensembl.org/id/ENSP00000416056.1" } ] } }, { "isoform_ac": "F6QYZ9-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAAR", "length": 152, "header": "tr|F6QYZ9-1|F6QYZ9_HUMAN Computationally mapped isoform of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "HSCHR6_MHC_MANN_CTG1", "start_pos": 2969525, "end_pos": 2969070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000415256.5", "url": "https://www.ensembl.org/id/ENST00000415256.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000393162.1", "url": "https://www.ensembl.org/id/ENSP00000393162.1" } ] } }, { "isoform_ac": "O95872-1", "url": "", "sequence": { "sequence": "MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYCENCDTHFQDSNHRTSTAHLLSLSQGPQPPNLPLGVPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRSAPQPRVTHFPAWDTRAVAGRERPPRVATLSWREERRREEKDRAWERDLRTYMNLEF", "length": 356, "header": "sp|O95872-1|GPAN1_HUMAN Isoform 1 of G patch domain and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GPANK1 PE=1 SV=1 CANONICAL=O95872-1" }, "locus": { "chromosome": "6", "start_pos": 31664478, "end_pos": 31662269, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375896.9", "url": "https://www.ensembl.org/id/ENST00000375896.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000365060.4", "url": "https://www.ensembl.org/id/ENSP00000365060.4" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 256, "end_pos": 256, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95872", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95872" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O95872", "url": "http://phospho.elm.eu.org/byAccession/O95872.html" } ], "site_lbl": "Ser256" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.", "journal": "Genome Res.", "date": "2003", "authors": "Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L", "evidence": [ { "database": "UniProtKB", "id": "O95872", "url": "https://www.uniprot.org/uniprot/O95872" } ], "reference": [ { "type": "PubMed", "id": "14656967", "url": "https://glygen.org/publication/PubMed/14656967" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O95872", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95872" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.", "journal": "Rheumatology (Oxford, England)", "date": "2008", "authors": "Harney SM, Vilarino-Guell C, Adamopoulos IE, Sims AM, Lawrence RW, Cardon LR, Newton JL, Meisel C, Pointon JJ, Darke C, Athanasou N, Wordsworth BP, Brown MA", "evidence": [ { "database": "RefSeq", "id": "NP_001186166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186166" } ], "reference": [ { "type": "PubMed", "id": "18835879", "url": "https://glygen.org/publication/PubMed/18835879" } ] }, { "title": "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.", "journal": "Nature", "date": "2011", "authors": "Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR, Futreal PA", "evidence": [ { "database": "UniProtKB", "id": "O95872", "url": "https://www.uniprot.org/uniprot/O95872" } ], "reference": [ { "type": "PubMed", "id": "21248752", "url": "https://glygen.org/publication/PubMed/21248752" } ] } ], "pathway": [ { "id": "hsa:7918", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7918", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZYU9-1", "protein_name": "G patch domain and ankyrin repeats 1", "gene_name": "Gpank1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGKVPARETEPSMSKPSLITFTPATDSSDLWKDGQQQAQLEKPEPVLDGAAARAFYEALIAEESGSPKPRRAEPTRERKRKRRRTTAREPVAAGVPRQGRALEDEDRVTQWILMAAQNGDLTELRRLLEPQEAGGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCELGGRDAAQLAEEAGFPEVARMVRESRGETRSPENQNRSPPSSSQFCEDCGAYFEDSNHRTSTAHLLSLSRRPQPSSLPLGVPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRSPTQPRVTHFAARDTRAVSGKERVPRVGTLSQRENRRREEKDRAWERDLRLYMNLEF", "length": 363 }, "evidence": [ { "id": "45931608", "url": "http://www.informatics.jax.org/homology/45931608", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q61858-1", "protein_name": "G patch domain and ankyrin repeat-containing protein 1", "gene_name": "Gpank1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGSLACHILALPSLHFLVSLTGMSRPSFIEFTPAADSSDLWKDGQQQPQQEKAEPVLDGAAARAFYEALIADDSSSSKPQRAEPMRERKKKRRRVTREPAAAGVPRQGRALEDEDRMAQWILLAAQNGDLTELRRLLEPQEAGGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCDLGGRDAAQLAEEAGFPEVARMVRESHGETRSPENQNRSTPSSSQFCEDCGAHFEDSNHHTSTAHLLSLSRRPQPSNLPLGVPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGYRSPPQPRVTHFAARDTRAVSGRERVPRVATLSQRENRRQEEKGRAWERDLRLYMNLEF", "length": 372 }, "evidence": [ { "id": "45931608", "url": "http://www.informatics.jax.org/homology/45931608", "database": "MGI" }, { "id": "O95872", "url": "https://omabrowser.org/oma/group/O95872/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V7A7-1", "protein_name": "G patch domain and ankyrin repeat-containing protein 1 homolog", "gene_name": "", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MNSQNELHPNWLALTTLPLQLKRFVRAGDPDFIAESPKAVKHQIDGLNGAEAREFYKEVLDAPTTCQPNLPSTHKTAQTRREPERILVPFDKSKFFRLATSNKVEELSQMKASEEDLNSRDSFGWTALMMAACEGATEAVSWLVQRGVQVETSDKSGNTALKLAQRKGHLDVVHLLESLPILEETSEEDESVDGNNPFYCEICKRDYKETPWPIHQTSTVHQFNLKALPAHKLHKFNISAKNRGLQLMVKQGWDQEHGLGPSQSGRLYPVKTVLRKQRTGLGIEQQSARVSHFGAFDLNAVRRRDPIYQPRRTRSDMQREKVREWKRERYLRRVLS", "length": 336 }, "evidence": [ { "id": "O95872", "url": "https://omabrowser.org/oma/group/O95872/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nucleic acid binding", "id": "GO:0003676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003676", "evidence": [ { "database": "UniProtKB", "id": "O95872", "url": "https://www.uniprot.org/uniprot/O95872" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], 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