{ "uniprot_canonical_ac": "O95870-1", "uniprot_ac": "O95870", "uniprot_id": "ABHGA_HUMAN", "mass": { "chemical_mass": 63243.0, "monoisotopic_mass": 63243.0 }, "refseq": { "ac": "NP_001170986", "name": "phosphatidylserine lipase ABHD16A isoform b", "summary": "A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" }, "gene_names": [ { "name": "ABHD16A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95870", "id": "O95870" }, { "name": "ABHD16A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986", "id": "NP_001170986" }, { "name": "BAT5; D6S82E; hBAT5; NG26; PP199; SPG86", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986", "id": "NP_001170986" }, { "name": "BAT5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95870", "id": "O95870" }, { "name": "G5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95870", "id": "O95870" }, { "name": "NG26", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95870", "id": "O95870" }, { "name": "PP199", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95870", "id": "O95870" }, { "name": "hCG_43724", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95870", "id": "O95870" } ], "protein_names": [ { "name": "Phosphatidylserine lipase ABHD16A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95870" }, { "name": "3.1.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "3.1.1.23", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "Abhydrolase domain-containing protein 16A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "Alpha/beta hydrolase domain-containing protein 16A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "HLA-B associated transcript 5; abhydrolase domain-containing protein 16A; protein G5; alpha/beta hydrolase domain-containing protein 16A; protein ABHD16A; monoacylglycerol lipase ABHD16A; phosphatidylserine lipase ABHD16A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986", "id": "NP_001170986" }, { "name": "HLA-B-associated transcript 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "Monoacylglycerol lipase ABHD16A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "Protein G5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "hBAT5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95870" }, { "name": "phosphatidylserine lipase ABHD16A isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986", "id": "NP_001170986" } ], "function": [ { "annotation": "A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" } ] }, { "annotation": "A homozygous ABHD16A variant causes a complex hereditary spastic paraplegia with developmental delay, absent speech, and characteristic face.", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" }, { "database": "PubMed", "id": "34866177", "url": "https://glygen.org/publication/PubMed/34866177" } ] }, { "annotation": "ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies.", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" }, { "database": "PubMed", "id": "34587489", "url": "https://glygen.org/publication/PubMed/34587489" } ] }, { "annotation": "Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" }, { "database": "PubMed", "id": "32462874", "url": "https://glygen.org/publication/PubMed/32462874" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" }, { "database": "PubMed", "id": "18835879", "url": "https://glygen.org/publication/PubMed/18835879" } ] }, { "annotation": "Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870#function" }, { "database": "UniProtKB", "id": "Q9Z1Q2", "url": "https://www.uniprot.org/uniprot/Q9Z1Q2#function" }, { "database": "PubMed", "id": "25290914", "url": "https://glygen.org/publication/PubMed/25290914" } ] } ], "disease": [ { "disease_id": "DOID:0112342", "recommended_name": { "id": "DOID:0112342", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112342", "name": "hereditary spastic paraplegia 86", "description": "A hereditary spastic paraplegia characterized by early childhood onset of global developmental delay and early-onset progressive spasticity mainly affecting the lower limbs but also affecting the upper lmbs that has_material_basis_in homozygous or compound heterozygous mutation in the ABHD16A gene on chromosome 6p21.33." }, "synonyms": [ { "id": "DOID:0112342", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112342", "name": "SPG86", "description": "" }, { "id": "DOID:0112342", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112342", "name": "spastic paraplegia 86 autosomal recessive", "description": "" }, { "id": "MONDO:0030673", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030673", "name": "spastic paraplegia 86, autosomal recessive", "description": "" }, { "id": "MONDO:0030673", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030673", "name": "SPG86", "description": "" }, { "id": "MONDO:0030673", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030673", "name": "spastic paraplegia 86, autosomal recessive", "description": "" }, { "id": "MIM:619735", "resource": "MIM", "url": "https://www.omim.org/entry/619735", "name": "Spastic paraplegia 86, autosomal recessive", "description": "Spastic paraplegia 86, autosomal recessive" } ], "evidence": [ { "id": "619735", "database": "MIM", "url": "https://www.omim.org/entry/619735" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "83.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "63.62", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.64", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "95.71", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "95.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "82.65", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "85.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "97.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "90.82", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000204427", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204427" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95870" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95870" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O95870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95870" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O95870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95870" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O95870", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95870" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"A0A0G2JJD3", "url": "https://www.uniprot.org/uniprot/A0A0G2JJD3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JJD3-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JJD3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z3G6", "url": "https://www.uniprot.org/uniprot/F2Z3G6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z3G6-1", "url": "https://www.uniprot.org/uniprot/F2Z3G6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z3H2", "url": "https://www.uniprot.org/uniprot/F2Z3H2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z3H2-1", "url": "https://www.uniprot.org/uniprot/F2Z3H2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z3Q3", "url": "https://www.uniprot.org/uniprot/F2Z3Q3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F2Z3Q3-1", "url": "https://www.uniprot.org/uniprot/F2Z3Q3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95870-1", "url": "https://www.uniprot.org/uniprot/O95870-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95870-2", "url": "https://www.uniprot.org/uniprot/O95870-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL", "length": 558, "header": "sp|O95870-1|ABHGA_HUMAN Isoform 1 of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=3 CANONICAL=O95870-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JI89-1", "url": "", "sequence": { "sequence": "MPPPALFLSSLYPRLEFQNDFYRSCIRRSSPQPPPNLAWRPESLYSGELAGGGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGC", "length": 263, "header": "tr|A0A0G2JI89-1|ABHGA_HUMAN Computationally mapped isoform of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=4 CANONICAL=O95870-1" }, "locus": { "chromosome": "HSCHR6_MHC_DBB_CTG1", "start_pos": 2950532, "end_pos": 2938322, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000422404.5", "url": "https://www.ensembl.org/id/ENST00000422404.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000394825.1", "url": "https://www.ensembl.org/id/ENSP00000394825.1" } ] } }, { "isoform_ac": "A0A0G2JJD3-1", "url": "", "sequence": { "sequence": "MSQLARRRSRYGLTSRAHNTSEAGRAGPAGGPAAGRAAARAGAMAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL", "length": 601, "header": "tr|A0A0G2JJD3-1|ABHGA_HUMAN Computationally mapped isoform of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=1 CANONICAL=O95870-1" }, "locus": { "chromosome": "HSCHR6_MHC_DBB_CTG1", "start_pos": 2951174, "end_pos": 2934979, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000413853.6", "url": "https://www.ensembl.org/id/ENST00000413853.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000416404.2", "url": "https://www.ensembl.org/id/ENSP00000416404.2" } ] } }, { "isoform_ac": "F2Z3G6-1", "url": "", "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWVT", "length": 46, "header": "tr|F2Z3G6-1|F2Z3G6_HUMAN Computationally mapped isoform of Abhydrolase domain containing 16A, phospholipase OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=1 CANONICAL=O95870-1" }, "locus": { "chromosome": "6", "start_pos": 31703281, "end_pos": 31701023, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000498420.5", "url": "https://www.ensembl.org/id/ENST00000498420.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000420628.1", "url": "https://www.ensembl.org/id/ENSP00000420628.1" } ] } }, { "isoform_ac": "F2Z3H2-1", "url": "", "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALVT", "length": 65, "header": "tr|F2Z3H2-1|ABHGA_HUMAN Computationally mapped isoform of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=1 CANONICAL=O95870-1" }, "locus": { "chromosome": "6", "start_pos": 31703281, "end_pos": 31701023, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000495769.5", "url": "https://www.ensembl.org/id/ENST00000495769.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000418170.1", "url": "https://www.ensembl.org/id/ENSP00000418170.1" } ] } }, { "isoform_ac": "F2Z3Q3-1", "url": "", "sequence": { "sequence": "MPPPALFLSSLYPRLEFQNDFYRSCIRRSSPQPPPNLAWRPESLYSGELAGGGYVLSAPCPGETC", "length": 65, "header": "tr|F2Z3Q3-1|ABHGA_HUMAN Computationally mapped isoform of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=1 CANONICAL=O95870-1" }, "locus": { "chromosome": "6", "start_pos": 31702768, "end_pos": 31702093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000492084.5", "url": "https://www.ensembl.org/id/ENST00000492084.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000420585.1", "url": "https://www.ensembl.org/id/ENSP00000420585.1" } ] } }, { "isoform_ac": "O95870-1", "url": "", "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL", "length": 558, "header": "sp|O95870-1|ABHGA_HUMAN Isoform 1 of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=3 CANONICAL=O95870-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2959113, "end_pos": 2943039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000446529.6", "url": "https://www.ensembl.org/id/ENST00000446529.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000395665.2", "url": "https://www.ensembl.org/id/ENSP00000395665.2" } ] } }, { "isoform_ac": "O95870-2", "url": "", "sequence": { "sequence": "MPPPALFLSSLYPRLEFQNDFYRSCIRRSSPQPPPNLAWRPESLYSGELAGGGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL", "length": 525, "header": "sp|O95870-2|ABHGA_HUMAN Isoform 2 of Phosphatidylserine lipase ABHD16A OS=Homo sapiens OX=9606 GN=ABHD16A PE=1 SV=3 CANONICAL=O95870-1" }, "locus": { "chromosome": "HSCHR6_MHC_QBL_CTG1", "start_pos": 2958600, "end_pos": 2943039, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000548592.1", "url": "https://www.ensembl.org/id/ENST00000548592.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000448431.1", "url": "https://www.ensembl.org/id/ENSP00000448431.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.", "journal": "Nat. Biotechnol.", "date": "2003", "authors": "Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "reference": [ { "type": "PubMed", "id": "12665801", "url": "https://glygen.org/publication/PubMed/12665801" } ] }, { "title": "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.", "journal": "Genome Res.", "date": "2003", "authors": "Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "reference": [ { "type": "PubMed", "id": "14656967", "url": "https://glygen.org/publication/PubMed/14656967" } ] }, { "title": "Large-scale cDNA transfection screening for genes related to cancer development and progression.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "reference": [ { "type": "PubMed", "id": "15498874", "url": "https://glygen.org/publication/PubMed/15498874" } ] }, { "title": "Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis.", "journal": "Rheumatology (Oxford, England)", "date": "2008", "authors": "Harney SM, Vilarino-Guell C, Adamopoulos IE, Sims AM, Lawrence RW, Cardon LR, Newton JL, Meisel C, Pointon JJ, Darke C, Athanasou N, Wordsworth BP, Brown MA", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" } ], "reference": [ { "type": "PubMed", "id": "18835879", "url": "https://glygen.org/publication/PubMed/18835879" } ] }, { "title": "Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).", "journal": "PloS one", "date": "2014", "authors": "Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, Nevalainen T, Laitinen JT", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "reference": [ { "type": "PubMed", "id": "25290914", "url": "https://glygen.org/publication/PubMed/25290914" } ] }, { "title": "Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC.", "journal": "Biochemistry", "date": "2020", "authors": "Singh S, Joshi A, Kamat SS", "evidence": [ { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" } ], "reference": [ { "type": "PubMed", "id": "32462874", "url": "https://glygen.org/publication/PubMed/32462874" } ] }, { "title": "Pathogenic Variants in ABHD16A Cause a Novel Psychomotor Developmental Disorder With Spastic Paraplegia.", "journal": "Frontiers in neurology", "date": "2021", "authors": "Yahia A, Elsayed LEO, Valter R, Hamed AAA, Mohammed IN, Elseed MA, Salih MA, Esteves T, Auger N, Abubaker R, Koko M, Abozar F, Malik H, Adil R, Emad S, Musallam MA, Idris R, Eltazi IZM, Babai A, Ahmed EAA, Abd Allah ASI, Mairey M, Ahmed AKMA, Elbashir MI, Brice A, Ibrahim ME, Ahmed AE, Lamari F, Stevanin G", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "reference": [ { "type": "PubMed", "id": "34489854", "url": "https://glygen.org/publication/PubMed/34489854" } ] }, { "title": "ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies.", "journal": "American journal of human genetics", "date": "2021", "authors": "Lemire G, Ito YA, Marshall AE, Chrestian N, Stanley V, Brady L, Tarnopolsky M, Curry CJ, Hartley T, Mears W, Derksen A, Rioux N, Laflamme N, Hutchison HT, Pais LS, Zaki MS, Sultan T, Dane AD, Gleeson JG, Vaz FM, Kernohan KD, Bernard G, Boycott KM", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" }, { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" } ], "reference": [ { "type": "PubMed", "id": "34587489", "url": "https://glygen.org/publication/PubMed/34587489" } ] }, { "title": "A homozygous ABHD16A variant causes a complex hereditary spastic paraplegia with developmental delay, absent speech, and characteristic face.", "journal": "Clinical genetics", "date": "2022", "authors": "Miyake N, Silva S, Troncoso M, Okamoto N, Andachi Y, Kato M, Iwabuchi C, Hirose M, Fujita A, Uchiyama Y, Matsumoto N", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" }, { "database": "RefSeq", "id": "NP_001170986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170986" } ], "reference": [ { "type": "PubMed", "id": "34866177", "url": "https://glygen.org/publication/PubMed/34866177" } ] } ], "pathway": [ { "id": "hsa:7920", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7920", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A287AWB5-1", "protein_name": "Phosphatidylserine lipase ABHD16A", "gene_name": "ABHD16A", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDSERAASGVPGTPTSVTTASSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEAAHRNQSAENKRQLANYNFDFRSWPVDFHWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTLLNQVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDVMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPEFPWSVGEDMSADGRRQLALFLAQKHLHNFEATHCTPLPAPNFQMPWHL", "length": 558 }, "evidence": [ { "id": "O95870", "url": "https://omabrowser.org/oma/group/O95870/", "database": "OMA" } ], "common_name": "Pig" }, { "uniprot_canonical_ac": "Q6MG55-1", "protein_name": "Phosphatidylserine lipase ABHD16A", "gene_name": "Abhd16a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDTDRAATSVPETPTAVPAASSSSWDSYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLVLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSAENKRQLANYNFDFRSWPVDFHWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTFLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIVIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMPDSWRALVTRTVRQHLNLNNAEQLCRFQGPVLLVRRTKDEIITTTVPEDIMSNRGNDLLLKLLQFRYPRVMTEEGLRAVRQWLEASSQLEEASIYSRWEVDEDWCVSVLRSYQAEHGPDFPWSVGEDMSVDGRRQLALFLARKHLHNFEATHCTPLPAQHFQMPWCL", "length": 558 }, "evidence": [ { "id": "45923175", "url": "http://www.informatics.jax.org/homology/45923175", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9VZF1-1", "protein_name": "GH07444p", "gene_name": "Dmel\\CG1309", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSFLNYVFGPNLYMEYRGVPEPQRKMYEAGAVEKFGEQILSTLSVMWSVGYYTSPLLVTFLYRRGYLVTDSIPTLAKITTSVGLIVILSLVMRGLGRKQSRSYSNMIKALVRAKSSKAPGDANSELRRFDIEFNAWPVDFDVKALTGDTKKPVVTARRREPIQLATLPCEAIAYLAINTFGLSMIYPGSVKLLQKLMRPMLISGRAKLIEDDNGIRYKVKTIDSNEIDTLFIDNRPNNVGNGKTLVICSEGNAGFYEVGIMATPVALKYSVLGWNHPGFAGSTGTPHPHQDKNAIDAVVQFAINNLRFPVEDIILYGWSIGGFSTLYAASVYPDVKGVVLDATFDDVLYLAVPRMPAALAGIVKVAIRNYCNLNNAELANEFNGPISFIRRTEDEIIAEDNHIDTNRGNFLVLSVLKHRYPNIFGASQLNKAKGLLSKPLEPYSIPVADEKLCMSRLITYASDEGKSFPMNIGADYSEEVRNLMAVFLLRKHLRDYNSTHCTQLPGEFFTMPWDIPTEQGFVFT", "length": 524 }, "evidence": [ { "id": "O95870", "url": "https://omabrowser.org/oma/group/O95870/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z1Q2-1", "protein_name": "Phosphatidylserine lipase ABHD16A", "gene_name": "Abhd16a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKLLSCVLGPRLYKIYRERDTDRAASSVPETPTAVPAASSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSAENKRQLANYNFDFRSWPVDFHWEEPSSRKGSRGGPSRRGVALLRPEPLHRGTADTFLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIVIYAWSIGGFTATWAAMSYPDISAVILDASFDDLVPLALKVMPDSWRALVTRTVRQHLNLNNSEQLCRFQGPVLLVRRTKDEIITTTVPEDIMSNRGNDLLLKLLQFRYPRVMVEEGLRAVRQWLEASSQLEEASIYSRWEVEEDWCVSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQHFQMPWHL", "length": 558 }, "evidence": [ { "id": "45923175", "url": "http://www.informatics.jax.org/homology/45923175", "database": "MGI" }, { "id": "O95870", "url": "https://omabrowser.org/oma/group/O95870/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phospholipase activity", "id": "GO:0004620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004620", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "pmid": "" }, { "name": "acylglycerol lipase activity", "id": "GO:0047372", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047372", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "monoacylglycerol catabolic process", "id": "GO:0052651", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052651", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "pmid": "" }, { "name": "prostaglandin catabolic process", "id": "GO:1905344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905344", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "pmid": "" }, { "name": "phosphatidylserine catabolic process", "id": "GO:0006660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006660", "evidence": [ { "database": "UniProtKB", "id": "O95870", "url": "https://www.uniprot.org/uniprot/O95870" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 137, "end_pos": 139, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "26132", "name": "", "equation": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "P97612-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "P15304-1", "P07687-1", "Q8N2K0-1", "P08910-1", "Q9BV23-1", "O95870-1", "O00519-1", "Q99685-1", "O00748-1", "P23141-1", "P07099-1", "Q05469-1", "Q8IY17-4", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "Q9QXM0-1", "O08914-1", "O35678-1", "P54310-1", "Q3TRM4-1", "Q8VCC2-1", "Q9D379-1" ], "evidence": [ { "id": "26132", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/26132" } ] }, { "id": "38487", "name": "", "equation": "1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "O54728-1", "P54318-1", "P15304-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q6P1J6-1", "Q05469-1", "P54317-1", "Q8IY17-4", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1", "P54310-1", "P17892-1", "Q3TRM4-1", "Q3TTY0-1", "P28321-1", "Q03649-1", "Q9VMM8-1" ], "evidence": [ { "id": "38487", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38487" } ] }, { "id": "38491", "name": "", "equation": "2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "O54728-1", "P15304-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q6P1J6-1", "Q05469-1", "Q8IY17-4", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1", "P54310-1", "Q3TRM4-1", "Q3TTY0-1", "P28321-1", "Q9VMM8-1" ], "evidence": [ { "id": "38491", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38491" } ] }, { "id": "39963", "name": "", "equation": "2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q8IY17-4", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1", "Q3TRM4-1", "P28321-1" ], "evidence": [ { "id": "39963", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39963" } ] }, { "id": "40919", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "O54728-1", "P04055-1", "P14423-1", "O95870-1", "Q9BZM2-1", "Q6P1J6-1", "Q9UNK4-1", "P14555-1", "P04054-1", "Q9Z1Q2-1", "Q9QZT4-1", "P31482-1", "Q9WVF6-1", "Q9Z0Y2-1", "Q3TTY0-1", "Q9VMM8-1" ], "evidence": [ { "id": "40919", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40919" } ] }, { "id": "41752", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "Q9QZT3-1", "O95870-1", "Q9BZM2-1", "O15496-1", "Q9Z1Q2-1", "P0C871-1", "Q9QZT4-1", "Q9QXX3-1" ], "evidence": [ { "id": "41752", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41752" } ] }, { "id": "44312", "name": "", "equation": "1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1" ], "evidence": [ { "id": "44312", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44312" } ] }, { "id": "44500", "name": "", "equation": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "O95870-1", "Q9Z1Q2-1" ], "evidence": [ { "id": "44500", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44500" } ] }, { "id": "44516", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "O95870-1", "Q9Z1Q2-1" ], "evidence": [ { "id": "44516", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44516" } ] }, { "id": "44520", "name": "", "equation": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "O95870-1", "Q9Z1Q2-1" ], "evidence": [ { "id": "44520", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44520" } ] }, { "id": "44524", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "P51433-1", "Q9QZT3-1", "P14423-1", "O95870-1", "P14555-1", "O15496-1", "P39877-1", "Q9NZK7-1", "Q9Z1Q2-1", "P0C871-1", "P31482-1", "P97391-1", "Q9QUL3-1", "Q9QXX3-1" ], "evidence": [ { "id": "44524", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44524" } ] }, { "id": "44528", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "O95870-1", "Q9Z1Q2-1" ], "evidence": [ { "id": "44528", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44528" } ] }, { "id": "44540", "name": "", "equation": "1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "O95870-1", "Q9Z1Q2-1" ], "evidence": [ { "id": "44540", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44540" } ] }, { "id": "44728", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1" ], "evidence": [ { "id": "44728", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44728" } ] }, { "id": "44732", "name": "", "equation": "2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1" ], "evidence": [ { "id": "44732", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44732" } ] }, { "id": "45412", "name": "", "equation": "H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "Q8R431-1", "O95870-1", "Q99685-1", "Q9Z1Q2-1", "O35678-1" ], "evidence": [ { "id": "45412", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45412" } ] }, { "id": "45416", "name": "", "equation": "11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6MG55-1", "Q8R431-1", "O95870-1", "Q99685-1", "Q9Z1Q2-1", "O35678-1" ], "evidence": [ { "id": "45416", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/45416" } ] }, { "id": "48428", "name": "", "equation": "1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5XI64-1", "Q6AYT7-1", "Q6MG55-1", "Q8R431-1", "Q8N2K0-1", "Q9BV23-1", "O95870-1", "Q99685-1", "Q8R2Y0-1", "Q9Z1Q2-1", "Q99LR1-1", "O35678-1" ], "evidence": [ { "id": "48428", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48428" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00519", "gene_name": "FAAH", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "O00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00519" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "O00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00519" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "O00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00519" } ] } ] }, { "uniprot_ac": "O00748", "gene_name": "CES2", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] } ] }, { "uniprot_ac": "O08914", "gene_name": "Faah", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "O08914", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08914" } ] } ] }, { "uniprot_ac": "O15496", "gene_name": "PLA2G10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O15496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15496" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O15496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15496" } ] } ] }, { "uniprot_ac": "O35678", "gene_name": "Mgll", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "O35678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35678" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "O35678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35678" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O95870", "gene_name": "ABHD16A", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "O95870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95870" } ] } ] }, { "uniprot_ac": "P04054", "gene_name": "PLA2G1B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] } ] }, { "uniprot_ac": "P04055", "gene_name": "Pla2g1b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] } ] }, { "uniprot_ac": "P07099", "gene_name": "EPHX1", "activity": [ { "ec_number": "3.3.2.9", "activity": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol.", "evidence": [ { "id": "P07099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07099" } ] }, { "ec_number": "3.3.2.9", "activity": "", "evidence": [ { "id": "P07099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07099" } ] } ] }, { "uniprot_ac": "P07687", "gene_name": "Ephx1", "activity": [ { "ec_number": "3.3.2.9", "activity": "1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol.", "evidence": [ { "id": "P07687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07687" } ] }, { "ec_number": "3.3.2.9", "activity": "", "evidence": [ { "id": "P07687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07687" } ] } ] }, { "uniprot_ac": "P08910", "gene_name": "ABHD2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P08910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08910" } ] } ] }, { "uniprot_ac": "P0C871", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] } ] }, { "uniprot_ac": "P14423", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] } ] }, { "uniprot_ac": "P14555", "gene_name": "PLA2G2A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] } ] }, { "uniprot_ac": "P15304", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P15304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15304" } ] } ] }, { "uniprot_ac": "P17892", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P17892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17892" } ] } ] }, { "uniprot_ac": "P23141", "gene_name": "CES1", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] } ] }, { "uniprot_ac": "P28321", "gene_name": "YJU3", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P28321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28321" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P28321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28321" } ] } ] }, { "uniprot_ac": "P31482", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] } ] }, { "uniprot_ac": "P39877", "gene_name": "PLA2G5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] } ] }, { "uniprot_ac": "P51433", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] } ] }, { "uniprot_ac": "P54310", "gene_name": "Lipe", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "P54310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54310" } ] } ] }, { "uniprot_ac": "P54317", "gene_name": "PNLIPRP2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54317" } ] } ] }, { "uniprot_ac": "P54318", "gene_name": "Pnliprp2", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] }, { "ec_number": "3.1.1.26", "activity": "a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 a fatty acid + 2 H(+).", "evidence": [ { "id": "P54318", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54318" } ] } ] }, { "uniprot_ac": "P97391", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] } ] }, { "uniprot_ac": "P97612", "gene_name": "Faah", "activity": [ { "ec_number": "3.5.1.99", "activity": "(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+).", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] }, { "ec_number": "3.5.1.99", "activity": "", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P97612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97612" } ] } ] }, { "uniprot_ac": "Q03649", "gene_name": "MGL2", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q03649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03649" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q03649", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03649" } ] } ] }, { "uniprot_ac": "Q05469", "gene_name": "LIPE", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "a monoacylglycerol + H2O = a fatty acid + glycerol + H(+).", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] }, { "ec_number": "3.1.1.79", "activity": "", "evidence": [ { "id": "Q05469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05469" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q5XI64", "gene_name": "Abhd6", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q5XI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI64" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q5XI64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XI64" } ] } ] }, { "uniprot_ac": "Q6AYT7", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.1.23", "activity": 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