{ "uniprot_canonical_ac": "O95868-1", "uniprot_ac": "O95868", "uniprot_id": "LY66D_HUMAN", "mass": { "chemical_mass": 13691.0, "monoisotopic_mass": 13691.0 }, "refseq": { "ac": "NP_067069", "name": "lymphocyte antigen 6 complex locus protein G6d precursor", "summary": "LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" }, "gene_names": [ { "name": "LY6G6D", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95868", "id": "O95868" }, { "name": "C6orf23; G6D; LY6-D; MEGT1; NG25", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069", "id": "NP_067069" }, { "name": "C6orf23", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95868", "id": "O95868" }, { "name": "G6D", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95868", "id": "O95868" }, { "name": "LY6G6D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069", "id": "NP_067069" }, { "name": "MEGT1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95868", "id": "O95868" }, { "name": "NG25", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95868", "id": "O95868" } ], "protein_names": [ { "name": "Lymphocyte antigen 6 complex locus protein G6d", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95868" }, { "name": "Megakaryocyte-enhanced gene transcript 1 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95868" }, { "name": "Protein Ly6-D", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95868" }, { "name": "lymphocyte antigen 6 complex locus protein G6d precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069", "id": "NP_067069" }, { "name": "lymphocyte antigen-6 G6D; lymphocyte antigen 6 complex locus protein G6d; protein Ly6-D; megakaryocyte-enhanced gene transcript 1 protein; lymphocyte antigen 6 complex, locus G6D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069", "id": "NP_067069" } ], "function": [ { "annotation": "Combined targeting of STAT5 and MAPK pathways has superior therapeutic effects on immune resistance. In addition, the new identified LY6G6D antigen is a promising molecular target for human microsatellite-stable colorectal cancers Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" }, { "database": "PubMed", "id": "30670049", "url": "https://glygen.org/publication/PubMed/30670049" } ] }, { "annotation": "Frequencies of the DRB1, DQA1, DQB1 and TNFA alleles in immigrant population of West Siberia", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" }, { "database": "PubMed", "id": "19807019", "url": "https://glygen.org/publication/PubMed/19807019" } ] }, { "annotation": "LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" } ] }, { "annotation": "LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" }, { "database": "PubMed", "id": "36159851", "url": "https://glygen.org/publication/PubMed/36159851" } ] }, { "annotation": "Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" }, { "database": "PubMed", "id": "20438785", "url": "https://glygen.org/publication/PubMed/20438785" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" }, { "database": "PubMed", "id": "20406964", "url": "https://glygen.org/publication/PubMed/20406964" }, { "database": "PubMed", "id": "19423540", "url": "https://glygen.org/publication/PubMed/19423540" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs370412650", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370412650" }, { "id": "rs370412650", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370412650" }, { "id": "rs370412650", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs370412650#frequency_tab" }, { "id": "rs370412650", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs370412650" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 105, "end_pos": 105, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSA->NST).", "chr_id": "6", "chr_pos": "31717715", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A105", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs956503691", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs956503691" }, { "id": "rs956503691", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs956503691#frequency_tab" }, { "id": "rs956503691", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs956503691" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 28, "end_pos": 28, "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NCG->NCS).", "chr_id": "6", "chr_pos": "31715528", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G28", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1380235788", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1380235788" }, { "id": "rs1380235788", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1380235788#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 32, "end_pos": 32, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS).", "chr_id": "6", "chr_pos": "31715541", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S32", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs769015501", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769015501" }, { "id": "rs769015501", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs769015501" }, { "id": "rs769015501", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs769015501#frequency_tab" }, { "id": "rs769015501", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs769015501" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 41, "end_pos": 41, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "6", "chr_pos": "31715568", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T41", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95868", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95868" } ], "glycoeffect": [], "start_pos": 9, "end_pos": 9, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "L", "sequence_mut": "V", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "6", "chr_pos": "31715380", "ref_nt": "T", "alt_nt": "G", 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"evidence": [ { "database": "Bgee", "id": "ENSG00000244355", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244355" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "48.5", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000244355", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244355" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "45.74", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000244355", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000244355" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "21.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000244355", "url": 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in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95868", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95868" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95868" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O95868", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95868" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNRRCFLRGLKIPLGSLKSHLLCPRRQVLKPGVQHPSFILSLSPSDLDSPTSSLRRSPSLQSSGDRVGGRRDLSSPQGLLPGRPVQQRRGKPCGPCRHFGCSSYRPDLSLARTVERI", "length": 174, "header": "tr|A0A140T952-1|LY66D_HUMAN Computationally mapped isoform of Lymphocyte antigen 6 complex locus protein G6d OS=Homo sapiens OX=9606 GN=LY6G6D PE=1 SV=1 CANONICAL=O95868-1" }, "locus": { "chromosome": "HSCHR6_MHC_DBB_CTG1", "start_pos": 2965565, "end_pos": 2963118, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000421590.1", "url": "https://www.ensembl.org/id/ENST00000421590.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000392479.1", "url": "https://www.ensembl.org/id/ENSP00000392479.1" } ] } }, { "isoform_ac": "A0A140T9N5-1", "url": "", "sequence": { "sequence": "MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSTCKEAVTTCGEGRPQPGLEQIKLPGNRRCFLRGLKIPLGSLKSHLLCPRRQVLKPGVQHPSFILSLSPSDLDSPTSSLRRSPSLQSSGDRVGGRRDLSSPQGLLPGRPVQQRRGKPCGPCRHFGCSSYRPDLSLARTVERI", "length": 174, "header": "tr|A0A140T9N5-1|A0A140T9N5_HUMAN Computationally mapped isoform of Lymphocyte antigen 6 complex locus protein G6d OS=Homo sapiens OX=9606 GN=LY6G6D PE=1 SV=1 CANONICAL=O95868-1" }, "locus": { "chromosome": "HSCHR6_MHC_SSTO_CTG1", "start_pos": 3017099, "end_pos": 3014652, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430137.1", "url": "https://www.ensembl.org/id/ENST00000430137.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000408650.1", "url": "https://www.ensembl.org/id/ENSP00000408650.1" } ] } }, { "isoform_ac": "A0A140T9R8-1", "url": "", "sequence": { "sequence": "MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNRRCFLRGLKIPLGSLKSHLLCPRRQVLKPGVQHPSFILSLSPSDLDSPTSSLRRSPSLQSSGDRVGGRRDLSSPQGLLPGRPVQQRRGKPCGPCRHFGCSSYRPDLSLARTVERI", "length": 174, "header": "tr|A0A140T9R8-1|A0A140T9R8_HUMAN Computationally mapped isoform of Lymphocyte antigen 6 complex locus protein G6d OS=Homo sapiens OX=9606 GN=LY6G6D PE=1 SV=1 CANONICAL=O95868-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 3059678, "end_pos": 3057233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000439522.1", "url": "https://www.ensembl.org/id/ENST00000439522.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000411977.1", "url": "https://www.ensembl.org/id/ENSP00000411977.1" } ] } }, { "isoform_ac": "A0A140T9V5-1", "url": "", "sequence": { "sequence": "MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNRRCFLRGLKIPLGSLKSHLLCPRRQVLKPGVQHPSFILSLSPSDLDSPTSSLRRSPSLQSSGDRVGGRRDLSSPQGLLPGRPVQQRRGKPCGPCRHFGCSSYRPDLSLARTVERI", "length": 174, "header": "tr|A0A140T9V5-1|A0A140T9V5_HUMAN Computationally mapped isoform of Lymphocyte antigen 6 complex locus protein G6d OS=Homo sapiens OX=9606 GN=LY6G6D PE=1 SV=1 CANONICAL=O95868-1" }, "locus": { "chromosome": "HSCHR6_MHC_COX_CTG1", "start_pos": 3195091, "end_pos": 3192640, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445443.1", "url": "https://www.ensembl.org/id/ENST00000445443.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000414791.1", "url": "https://www.ensembl.org/id/ENSP00000414791.1" } ] } }, { "isoform_ac": "F6XWZ1-1", "url": "", "sequence": { "sequence": "MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNRRCFLRGLKIPLGSLKSHLLCPRRQVLKPGVQHPSFILSLSPSDLDSPTSSLRRSPSLQSSGDRVGGRRDLSSPQGLLPGRPVQQRRGKPCGPCRHFGCSSYRPDLSLARTVERI", "length": 174, "header": "tr|F6XWZ1-1|LY66D_HUMAN Computationally mapped isoform of Lymphocyte antigen 6 complex locus protein G6d OS=Homo sapiens OX=9606 GN=LY6G6D PE=1 SV=1 CANONICAL=O95868-1" }, "locus": { "chromosome": "6", "start_pos": 31717803, "end_pos": 31715356, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000375824.1", "url": "https://www.ensembl.org/id/ENST00000375824.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000364984.1", "url": "https://www.ensembl.org/id/ENSP00000364984.1" } ] } }, { "isoform_ac": "O95868-1", "url": "", "sequence": { "sequence": "MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNPPVTLIHQHPACVAAHHCNQVETESVGDVTYPAHRDCYLGDLCNSAVASHVAPAGILAAAATALTCLLPGLWSG", "length": 133, "header": "sp|O95868-1|LY66D_HUMAN Isoform 1 of Lymphocyte antigen 6 complex locus protein G6d OS=Homo sapiens OX=9606 GN=LY6G6D PE=1 SV=1 CANONICAL=O95868-1" }, "locus": { "chromosome": "HSCHR6_MHC_MCF_CTG1", "start_pos": 3059676, "end_pos": 3057233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000444880.6", "url": "https://www.ensembl.org/id/ENST00000444880.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000395722.2", "url": "https://www.ensembl.org/id/ENSP00000395722.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "predicted", "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine O-GalNAcylation", "start_pos": 40, "start_aa": "Thr", "end_pos": 40, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr40", "evidence": [ { "id": "O95868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95868#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "O-GalNAcylation", "site_category": "predicted", "site_seq": "T", "relation": "attached", "comment": "O-linked (GalNAc...) threonine O-GalNAcylation", "start_pos": 41, "start_aa": "Thr", "end_pos": 41, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr41", "evidence": [ { "id": "O95868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95868#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.", "journal": "J. Immunol.", "date": "1999", "authors": "Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD", "evidence": [ { "database": "UniProtKB", "id": "O95868", "url": "https://www.uniprot.org/uniprot/O95868" } ], "reference": [ { "type": "PubMed", "id": "10384126", "url": "https://glygen.org/publication/PubMed/10384126" } ] }, { "title": "Structure and expression of the human glycosylphosphatidylinositol phospholipase D1 (GPLD1) gene.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Schofield JN, Rademacher TW", "evidence": [ { "database": "Reactome", "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125" } ], "reference": [ { "type": "PubMed", "id": "11072085", "url": "https://glygen.org/publication/PubMed/11072085" } ] }, { "title": "Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms.", "journal": "Genomics", "date": "2002", "authors": "Mallya M, Campbell RD, Aguado B", "evidence": [ { "database": "UniProtKB", "id": "O95868", "url": "https://www.uniprot.org/uniprot/O95868" } ], "reference": [ { "type": "PubMed", "id": "12079290", "url": "https://glygen.org/publication/PubMed/12079290" } ] }, { "title": "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.", "journal": "Genome Res.", "date": "2003", "authors": "Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L", "evidence": [ { "database": "UniProtKB", "id": "O95868", "url": "https://www.uniprot.org/uniprot/O95868" } ], "reference": [ { "type": "PubMed", "id": "14656967", "url": "https://glygen.org/publication/PubMed/14656967" } ] }, { "title": "Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands.", "journal": "Protein science : a publication of the Protein Society", "date": "2006", "authors": "Mallya M, Campbell RD, Aguado B", "evidence": [ { "database": "UniProtKB", "id": "O95868", "url": "https://www.uniprot.org/uniprot/O95868" } ], "reference": [ { "type": "PubMed", "id": "17008713", "url": "https://glygen.org/publication/PubMed/17008713" } ] }, { "title": "Common variation in genes related to innate immunity and risk of adult glioma.", "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology", "date": "2009", "authors": "Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" } ], "reference": [ { "type": "PubMed", "id": "19423540", "url": "https://glygen.org/publication/PubMed/19423540" } ] }, { "title": "[Detection of LY6G6D gene exon-intron structure,].", "journal": "Molekuliarnaia biologiia", "date": "2009", "authors": "Beliakov IS, Karakasheva TA, Mazurenko NN", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" } ], "reference": [ { "type": "PubMed", "id": "19807019", "url": "https://glygen.org/publication/PubMed/19807019" } ] }, { "title": "Risk of meningioma and common variation in genes related to innate immunity.", "journal": "Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology", "date": "2010", "authors": "Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" } ], "reference": [ { "type": "PubMed", "id": "20406964", "url": "https://glygen.org/publication/PubMed/20406964" } ] }, { "title": "Polymorphisms in innate immunity genes and risk of childhood leukemia.", "journal": "Human immunology", "date": "2010", "authors": "Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" } ], "reference": [ { "type": "PubMed", "id": "20438785", "url": "https://glygen.org/publication/PubMed/20438785" } ] }, { "title": "A glycan-phosphatidylinositol-specific phospholipase D in human serum.", "journal": "Science (New York, N.Y.)", "date": "1987", "authors": "Davitz MA, Hereld D, Shak S, Krakow J, Englund PT, Nussenzweig V", "evidence": [ { "database": "Reactome", "id": "R-HSA-163125", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163125" } ], "reference": [ { "type": "PubMed", "id": "2443973", "url": "https://glygen.org/publication/PubMed/2443973" } ] }, { "title": "JAK/Stat5-mediated subtype-specific lymphocyte antigen 6 complex, locus G6D (LY6G6D) expression drives mismatch repair proficient colorectal cancer.", "journal": "Journal of experimental & clinical cancer research : CR", "date": "2019", "authors": "Giordano G, Parcesepe P, D'Andrea MR, Coppola L, Di Raimo T, Remo A, Manfrin E, Fiorini C, Scarpa A, Amoreo CA, Conciatori F, Milella M, Caruso FP, Cerulo L, Porras A, Pancione M", "evidence": [ { "database": "RefSeq", "id": "NP_067069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067069" } ], "reference": [ { "type": "PubMed", "id": "30670049", "url": "https://glygen.org/publication/PubMed/30670049" } ] }, { "title": "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1988", "authors": "Low MG, Prasad AR", 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