{ "uniprot_canonical_ac": "O95834-1", "uniprot_ac": "O95834", "uniprot_id": "EMAL2_HUMAN", "mass": { "chemical_mass": 70679.0, "monoisotopic_mass": 70679.0 }, "refseq": { "ac": "NP_001180197", "name": "echinoderm microtubule-associated protein-like 2 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" }, "gene_names": [ { "name": "EML2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95834", "id": "O95834" }, { "name": "ELP70; EMAP-2; EMAP2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197", "id": "NP_001180197" }, { "name": "EMAP2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95834", "id": "O95834" }, { "name": "EMAPL2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95834", "id": "O95834" }, { "name": "EML2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197", "id": "NP_001180197" } ], "protein_names": [ { "name": "Echinoderm microtubule-associated protein-like 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95834" }, { "name": "EMAP-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95834" }, { "name": "HuEMAP-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95834" }, { "name": "echinoderm microtubule-associated protein-like 2 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197", "id": "NP_001180197" }, { "name": "microtubule-associated protein like echinoderm EMAP; echinoderm MT-associated protein (EMAP)-like protein 70; echinoderm microtubule associated protein like 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197", "id": "NP_001180197" } ], "function": [ { "annotation": "Both EMAP II and CXCR3 were essentially required for gp120-induced lung microvascular endothelial cell apoptosis.", "evidence": [ { "database": "RefSeq", "id": "NP_001180197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" }, { "database": "PubMed", "id": "24318111", "url": "https://glygen.org/publication/PubMed/24318111" } ] }, { "annotation": "EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules.", "evidence": [ { "database": "RefSeq", "id": "NP_001180197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" }, { "database": "PubMed", "id": "35963242", "url": "https://glygen.org/publication/PubMed/35963242" } ] }, { "annotation": "Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834#function" }, { "database": "PubMed", "id": "11694528", "url": "https://glygen.org/publication/PubMed/11694528" } ] }, { "annotation": "We have determined crystal structures of the coiled-coils from EML2 and EML4, which describe the structural basis of both EML self-association and oncogenic EML4-ALK activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001180197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" }, { "database": "PubMed", "id": "25740311", "url": "https://glygen.org/publication/PubMed/25740311" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "81.42", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "74.53", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "83.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "86.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "81.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "86.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "90.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "75.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "81.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "94.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125746", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125746" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95834", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95834" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": 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"MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"Protein" ] }, { "id": "K7ELB2", "url": "https://www.uniprot.org/uniprot/K7ELB2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ELB2-1", "url": "https://www.uniprot.org/uniprot/K7ELB2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ELI8", "url": "https://www.uniprot.org/uniprot/K7ELI8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ELI8-1", "url": "https://www.uniprot.org/uniprot/K7ELI8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EQR0", "url": "https://www.uniprot.org/uniprot/K7EQR0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7EQR0-1", "url": "https://www.uniprot.org/uniprot/K7EQR0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERR2", "url": "https://www.uniprot.org/uniprot/K7ERR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERR2-1", "url": "https://www.uniprot.org/uniprot/K7ERR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERR9", "url": "https://www.uniprot.org/uniprot/K7ERR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERR9-1", "url": "https://www.uniprot.org/uniprot/K7ERR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERY9", "url": "https://www.uniprot.org/uniprot/K7ERY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ERY9-1", "url": "https://www.uniprot.org/uniprot/K7ERY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ESL7", "url": "https://www.uniprot.org/uniprot/K7ESL7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "K7ESL7-1", "url": "https://www.uniprot.org/uniprot/K7ESL7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95834-1", "url": "https://www.uniprot.org/uniprot/O95834-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95834-2", "url": "https://www.uniprot.org/uniprot/O95834-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95834-3", "url": "https://www.uniprot.org/uniprot/O95834-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV", "length": 649, "header": "sp|O95834-1|EMAL2_HUMAN Isoform 1 of Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "isoforms": [ { "isoform_ac": "A0A0C4DGQ7-1", "url": "", "sequence": { "sequence": "MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEMAAAGHGDP", "length": 427, "header": "tr|A0A0C4DGQ7-1|A0A0C4DGQ7_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45639376, "end_pos": 45616827, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588308.5", "url": "https://www.ensembl.org/id/ENST00000588308.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468329.1", "url": "https://www.ensembl.org/id/ENSP00000468329.1" } ] } }, { "isoform_ac": "C9JRL6-1", "url": "", "sequence": { "sequence": "MGVIPEGPLWVSGSDDNLSGTSGMEVDDRVSALEQRLQLQEDELAVLKAALADALRRLRACEEQGAALRARGTPKGRAPPRLGTTASVCQLLKGLPTRTPLNGSGPPRRVGGYATSPSSPKKEATSGRSSVRRYLSPERLASVRREDPRSRTTSSSSNCSAKKEGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEVESRSVTQAGGQWHDLGSLQPPPPGFK", "length": 603, "header": "tr|C9JRL6-1|C9JRL6_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=2 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45644751, "end_pos": 45618863, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000399594.7", "url": "https://www.ensembl.org/id/ENST00000399594.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000382503.3", "url": "https://www.ensembl.org/id/ENSP00000382503.3" } ] } }, { "isoform_ac": "K7EII6-1", "url": "", "sequence": { "sequence": "FLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLV", "length": 181, "header": "tr|K7EII6-1|K7EII6_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45624782, "end_pos": 45616518, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590575.5", "url": "https://www.ensembl.org/id/ENST00000590575.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464764.1", "url": "https://www.ensembl.org/id/ENSP00000464764.1" } ] } }, { "isoform_ac": "K7EIK7-1", "url": "", "sequence": { "sequence": "MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRVLGKWPSAAEAALSSGIRVLFRPLVASLGPAWKNVPRKFCWKSAGDSPRDPPPRPQGHSQPSFPSSGPWETAVCKFYRQGRWREVRVFASWAPPCIPHSQWLWFPSSEPQFLWELELSLETGNRLPPCPFCPRLAMASCPLRMVPWGRPILCGFLHSAHPSINCP", "length": 773, "header": "tr|K7EIK7-1|K7EIK7_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45639376, "end_pos": 45607012, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000589876.5", "url": "https://www.ensembl.org/id/ENST00000589876.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464789.1", "url": "https://www.ensembl.org/id/ENSP00000464789.1" } ] } }, { "isoform_ac": "K7EIM1-1", "url": "", "sequence": { "sequence": "MFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGK", "length": 111, "header": "tr|K7EIM1-1|K7EIM1_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45638617, "end_pos": 45633070, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590043.5", "url": "https://www.ensembl.org/id/ENST00000590043.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464804.1", "url": "https://www.ensembl.org/id/ENSP00000464804.1" } ] } }, { "isoform_ac": "K7EIZ0-1", "url": "", "sequence": { "sequence": "WTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGP", "length": 51, "header": "tr|K7EIZ0-1|K7EIZ0_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45626752, "end_pos": 45621328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590819.5", "url": "https://www.ensembl.org/id/ENST00000590819.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464950.1", "url": "https://www.ensembl.org/id/ENSP00000464950.1" } ] } }, { "isoform_ac": "K7EJV6-1", "url": "", "sequence": { "sequence": "MSSFGAGKTKEVIFSVAWPSTQIWSPSPRDRWREPLRKGSRCRPTCASGTQFPSPPYTCWAWGCLTEPCAVWASPNLMEATCCVQWMNPMITCSRCGTGPRRPRWWMSSAPMRLYWWPPSTPRTPLCLSPAGNLTSTSGPWRGAA", "length": 145, "header": "tr|K7EJV6-1|K7EJV6_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45639376, "end_pos": 45626731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586195.5", "url": "https://www.ensembl.org/id/ENST00000586195.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000465339.1", "url": "https://www.ensembl.org/id/ENSP00000465339.1" } ] } }, { "isoform_ac": "K7EKG3-1", "url": "", "sequence": { "sequence": "IATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQ", "length": 223, "header": "tr|K7EKG3-1|K7EKG3_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45633111, "end_pos": 45621207, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588496.5", "url": "https://www.ensembl.org/id/ENST00000588496.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000465607.1", "url": "https://www.ensembl.org/id/ENSP00000465607.1" } ] } }, { "isoform_ac": "K7EKU5-1", "url": "", "sequence": { "sequence": "MFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFE", "length": 225, "header": "tr|K7EKU5-1|K7EKU5_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45638617, "end_pos": 45626705, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586770.5", "url": "https://www.ensembl.org/id/ENST00000586770.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000465786.1", "url": "https://www.ensembl.org/id/ENSP00000465786.1" } ] } }, { "isoform_ac": "K7EL23-1", "url": "", "sequence": { "sequence": "XGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYLEMGFHHLGQAGLELLTSGDPARCCGSCCLLGLQT", "length": 76, "header": "tr|K7EL23-1|EMAL2_HUMAN Computationally mapped isoform of Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45616495, "end_pos": 45614932, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586405.1", "url": "https://www.ensembl.org/id/ENST00000586405.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000465885.1", "url": "https://www.ensembl.org/id/ENSP00000465885.1" } ] } }, { "isoform_ac": "K7ELB2-1", "url": "", "sequence": { "sequence": "XHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPGPFQFYHPPG", "length": 73, "header": "tr|K7ELB2-1|K7ELB2_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45619090, "end_pos": 45615859, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587484.5", "url": "https://www.ensembl.org/id/ENST00000587484.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000465994.1", "url": "https://www.ensembl.org/id/ENSP00000465994.1" } ] } }, { "isoform_ac": "K7ELI8-1", "url": "", "sequence": { "sequence": "XLCAVDESNDHMLSVWDWAKETKVVDVKVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAG", "length": 121, "header": "tr|K7ELI8-1|K7ELI8_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45630032, "end_pos": 45617677, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588272.1", "url": "https://www.ensembl.org/id/ENST00000588272.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000466100.1", "url": "https://www.ensembl.org/id/ENSP00000466100.1" } ] } }, { "isoform_ac": "K7EQR0-1", "url": "", "sequence": { "sequence": "MFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGL", "length": 133, "header": "tr|K7EQR0-1|K7EQR0_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45638617, "end_pos": 45632906, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000593255.5", "url": "https://www.ensembl.org/id/ENST00000593255.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467941.1", "url": "https://www.ensembl.org/id/ENSP00000467941.1" } ] } }, { "isoform_ac": "K7ERR2-1", "url": "", "sequence": { "sequence": "MFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTI", "length": 98, "header": "tr|K7ERR2-1|K7ERR2_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45638617, "end_pos": 45633109, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590018.1", "url": "https://www.ensembl.org/id/ENST00000590018.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000468373.1", "url": "https://www.ensembl.org/id/ENSP00000468373.1" } ] } }, { "isoform_ac": "K7ERR9-1", "url": "", "sequence": { "sequence": "PLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKAGVQWHNLGSLQPPPPRFQRFS", "length": 91, "header": "tr|K7ERR9-1|K7ERR9_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45632971, "end_pos": 45628730, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000592853.5", "url": "https://www.ensembl.org/id/ENST00000592853.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468383.1", "url": "https://www.ensembl.org/id/ENSP00000468383.1" } ] } }, { "isoform_ac": "K7ERY9-1", "url": "", "sequence": { "sequence": "MFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKS", "length": 148, "header": "tr|K7ERY9-1|K7ERY9_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45638617, "end_pos": 45632861, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000591721.5", "url": "https://www.ensembl.org/id/ENST00000591721.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468470.1", "url": "https://www.ensembl.org/id/ENSP00000468470.1" } ] } }, { "isoform_ac": "K7ESL7-1", "url": "", "sequence": { "sequence": "MEVDDRVSALEQRLQLQEDELAVLKAALADALRRLRACEEQGAALRARGTPKGRAPPRLGTTASVCQLLKGLPTRTPLNGSGPPRRVGGYATSPSSPKKEATSGRSSVRRYLSPERLASVRREDPRSRTTSSSSNCSAKKE", "length": 141, "header": "tr|K7ESL7-1|K7ESL7_HUMAN Computationally mapped isoform of EMAP like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=8 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45642326, "end_pos": 45641643, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588172.1", "url": "https://www.ensembl.org/id/ENST00000588172.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000468768.1", "url": "https://www.ensembl.org/id/ENSP00000468768.1" } ] } }, { "isoform_ac": "O95834-1", "url": "", "sequence": { "sequence": "MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV", "length": 649, "header": "sp|O95834-1|EMAL2_HUMAN Isoform 1 of Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45639376, "end_pos": 45609666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000245925.8", "url": "https://www.ensembl.org/id/ENST00000245925.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000245925.3", "url": "https://www.ensembl.org/id/ENSP00000245925.3" } ] } }, { "isoform_ac": "O95834-2", "url": "", "sequence": { "sequence": "MSLDDNLSGTSGMEVDDRVSALEQRLQLQEDELAVLKAALADALRRLRACEEQGAALRARGTPKGRAPPRLGTTASVCQLLKGLPTRTPLNGSGPPRRVGGYATSPSSPKKEATSGRSSVRRYLSPERLASVRREDPRSRTTSSSSNCSAKKEGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV", "length": 796, "header": "sp|O95834-2|EMAL2_HUMAN Isoform 2 of Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45643588, "end_pos": 45609666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000536630.5", "url": "https://www.ensembl.org/id/ENST00000536630.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000442365.1", "url": "https://www.ensembl.org/id/ENSP00000442365.1" } ] } }, { "isoform_ac": "O95834-3", "url": "", "sequence": { "sequence": "MLERRALLWQREAGPGWGDRARAGTGGAGGGCGGAMAERGPAFCGLYDTSSLLRYCNDDNLSGTSGMEVDDRVSALEQRLQLQEDELAVLKAALADALRRLRACEEQGAALRARGTPKGRAPPRLGTTASVCQLLKGLPTRTPLNGSGPPRRVGGYATSPSSPKKEATSGRSSVRRYLSPERLASVRREDPRSRTTSSSSNCSAKKEGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSILQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV", "length": 850, "header": "sp|O95834-3|EMAL2_HUMAN Isoform 3 of Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1 CANONICAL=O95834-1" }, "locus": { "chromosome": "19", "start_pos": 45645444, "end_pos": 45609666, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587152.6", "url": "https://www.ensembl.org/id/ENST00000587152.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000468312.1", "url": "https://www.ensembl.org/id/ENSP00000468312.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O95834", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95834" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).", "journal": "Gene", "date": "1999", "authors": "Lepley D M, Palange J M, Suprenant K A", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "reference": [ { "type": "PubMed", "id": "10521658", "url": "https://glygen.org/publication/PubMed/10521658" } ] }, { "title": "The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus.", "journal": "The Journal of biological chemistry", "date": "2002-01-11", "authors": "Eichenmuller Bernd, Everley Patrick, Palange Jean, Lepley Denise, Suprenant Kathy A", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "reference": [ { "type": "PubMed", "id": "11694528", "url": "https://glygen.org/publication/PubMed/11694528" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "HIV envelope protein gp120-induced apoptosis in lung microvascular endothelial cells by concerted upregulation of EMAP II and its receptor, CXCR3.", "journal": "American journal of physiology. Lung cellular and molecular physiology", "date": "2014", "authors": "Green LA, Yi R, Petrusca D, Wang T, Elghouche A, Gupta SK, Petrache I, Clauss M", "evidence": [ { "database": "RefSeq", "id": "NP_001180197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" } ], "reference": [ { "type": "PubMed", "id": "24318111", "url": "https://glygen.org/publication/PubMed/24318111" } ] }, { "title": "Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical beta-propeller domain.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2014", "authors": "Richards MW, Law EW, Rennalls LP, Busacca S, O'Regan L, Fry AM, Fennell DA, Bayliss R", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "reference": [ { "type": "PubMed", "id": "24706829", "url": "https://glygen.org/publication/PubMed/24706829" } ] }, { "title": "Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.", "journal": "Biochem. J.", "date": "2015", "authors": "Richards MW, O'Regan L, Roth D, Montgomery JM, Straube A, Fry AM, Bayliss R", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" }, { "database": "RefSeq", "id": "NP_001180197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" } ], "reference": [ { "type": "PubMed", "id": "25740311", "url": "https://glygen.org/publication/PubMed/25740311" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95834", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95834" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "EML2-S constitutes a new class of proteins that recognizes and regulates the dynamics of tyrosinated microtubules.", "journal": "Current biology : CB", "date": "2022", "authors": "Hotta T, McAlear TS, Yue Y, Higaki T, Haynes SE, Nesvizhskii AI, Sept D, Verhey KJ, Bechstedt S, Ohi R", "evidence": [ { "database": "RefSeq", "id": "NP_001180197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180197" } ], "reference": [ { "type": "PubMed", "id": "35963242", "url": "https://glygen.org/publication/PubMed/35963242" } ] } ], "pathway": [ { "id": "hsa:24139", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:24139", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6P6T4-1", "protein_name": "Echinoderm microtubule-associated protein-like 2", "gene_name": "Eml2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSFGTGKTKEVIFSMEEGSVKMFLRGRPVPMLIPDELAPTYSLDTRSELPSSRLKLDWVYGYRGRDCRANLYLLPTGEVVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAVHPDMVTIATGQVAGTTKEGKPLPPHVRVWDSVSLSTLHVLGLGVFDRAVCCVAFSKSNGGNLLCAVDESNDHVLSVWDWAKESKVVDSKCSNEAVLVATFHPTDPNLLITCGKSHIYFWSLEGGNLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQEVLGAHDGGVFALCALRDGTLVSGGGRDRRVVLWGSDYSKVQEVEVPEDFGPVRTVAEGRGDTLYVGTTRNSILLGSVHTGFSLLVQGHVEELWGLATHPSRAQFVSCGQDKLVHLWSSETHQPVWSRSIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTDTRDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDAATCKQITSADTVRNVQWATATCVLGFGVFGIWPEGADGTDINAVARSHDGNLLVSADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMVLTTGGKDTSVLQWRVA", "length": 649 }, "evidence": [ { "id": "45926380", "url": "http://www.informatics.jax.org/homology/45926380", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TNG5-1", "protein_name": "Echinoderm microtubule-associated protein-like 2", "gene_name": "Eml2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSFGIGKTKEVIFSMEEGSVKMFLRGRPVPMLIPDELAPTYSLDTRSELPSSRLKLDWVYGYRGRDCRANLYLLPTGEVVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAVHPDMVTIATGQVAGTTKEGKPLPPHVRVWDSVSLSTLHVLGLGVFDRAVCCVAFSKSNGGNLLCAVDESNDHVLSVWDWAKESKVVDSKCSNEAVLVATFHPTDPSLLITCGKSHIYFWSLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQEVQGAHDGGVFALCALRDGTLVSGGGRDRRVVLWGSDYSKVQEVEVPEDFGPVRTVAEGRGDTLYVGTTRNSILLGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSETHQPVWSRSIEDPARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSTCFVTNSGDYEILYWDPVTCKQITSADTVRNVEWATATCVLGFGVFGIWPEGADGTDINAVARSHDGKLLVSADDFGKVHLFSYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVA", "length": 649 }, "evidence": [ { "id": "45926380", "url": "http://www.informatics.jax.org/homology/45926380", "database": "MGI" }, { "id": "O95834", "url": "https://omabrowser.org/oma/group/O95834/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of microtubule nucleation", "id": "GO:0010968", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010968", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "visual perception", "id": "GO:0007601", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007601", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "negative regulation of microtubule polymerization", "id": "GO:0031115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031115", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "spindle", "id": "GO:0005819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "microtubule associated complex", "id": "GO:0005875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005875", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "protein self-association", "id": "GO:0043621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "O95834", "url": "https://www.uniprot.org/uniprot/O95834" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }