{ "uniprot_canonical_ac": "O95825-1", "uniprot_ac": "O95825", "uniprot_id": "QORL1_HUMAN", "mass": { "chemical_mass": 38697.0, "monoisotopic_mass": 38697.0 }, "refseq": { "ac": "NP_665857", "name": "quinone oxidoreductase-like protein 1", "summary": "This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857" }, "gene_names": [ { "name": "CRYZL1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95825", "id": "O95825" }, { "name": "4P11; FERRY4; Fy-4; QOH-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857", "id": "NP_665857" }, { "name": "4P11", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95825", "id": "O95825" }, { "name": "CRYZL1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857", "id": "NP_665857" } ], "protein_names": [ { "name": "Quinone oxidoreductase-like protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95825" }, { "name": "1.-.-.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95825" }, { "name": "Protein 4P11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95825" }, { "name": "QOH-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95825" }, { "name": "Quinone oxidoreductase homolog 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95825" }, { "name": "Zeta-crystallin homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95825" }, { "name": "quinone oxidoreductase-like protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857", "id": "NP_665857" }, { "name": "quinone reductase-like 1; protein 4P11; zeta-crystallin homolog; quinone oxidoreductase homolog 1; crystallin, zeta (quinone reductase)-like 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857", "id": "NP_665857" } ], "function": [ { "annotation": "Data show that human and yeast zeta-crystallins bind AU-rich elements in RNA.", "evidence": [ { "database": "RefSeq", "id": "NP_665857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857" }, { "database": "PubMed", "id": "17497241", "url": "https://glygen.org/publication/PubMed/17497241" } ] }, { "annotation": "This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_665857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "85.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "84.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "80.89", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "66.83", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "94.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "68.04", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "93.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.14", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "67.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "87.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000205758", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000205758" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95825", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95825" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95825-2", "url": "https://www.uniprot.org/uniprot/O95825-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF", "length": 349, "header": "sp|O95825-1|QORL1_HUMAN Isoform 1 of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2 CANONICAL=O95825-1" }, "isoforms": [ { "isoform_ac": "A0A0C4DG14-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVEVLSRLGAVAHVCNPSTLGGQGGRIT", "length": 113, "header": "tr|A0A0C4DG14-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33616527, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000413017.2", "url": "https://www.ensembl.org/id/ENST00000413017.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000389209.2", "url": "https://www.ensembl.org/id/ENSP00000389209.2" } ] } }, { "isoform_ac": "A6NHJ8-1", "url": "", "sequence": { "sequence": "MWLLSQIGPLHYAKRRNHLERDVTMKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYL", "length": 325, "header": "tr|A6NHJ8-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33641244, "end_pos": 33595731, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000361534.6", "url": "https://www.ensembl.org/id/ENST00000361534.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000355075.2", "url": "https://www.ensembl.org/id/ENSP00000355075.2" } ] } }, { "isoform_ac": "A6NMA8-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF", "length": 334, "header": "tr|A6NMA8-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33589825, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000290244.9", "url": "https://www.ensembl.org/id/ENST00000290244.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000290244.5", "url": "https://www.ensembl.org/id/ENSP00000290244.5" } ] } }, { "isoform_ac": "A6NND8-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLSTYLKGCDGEVINWCFQTSVG", "length": 322, "header": "tr|A6NND8-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33589910, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000381540.7", "url": "https://www.ensembl.org/id/ENST00000381540.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000370951.3", "url": "https://www.ensembl.org/id/ENSP00000370951.3" } ] } }, { "isoform_ac": "A8MZ10-1", "url": "", "sequence": { "sequence": "MWLLSQIGPLHYAKRRNHLERDTQ", "length": 24, "header": "tr|A8MZ10-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33641244, "end_pos": 33640183, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000399442.1", "url": "https://www.ensembl.org/id/ENST00000399442.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000382371.1", "url": "https://www.ensembl.org/id/ENSP00000382371.1" } ] } }, { "isoform_ac": "C9JAL0-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLED", "length": 181, "header": "tr|C9JAL0-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33602268, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000431177.5", "url": "https://www.ensembl.org/id/ENST00000431177.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000405510.1", "url": "https://www.ensembl.org/id/ENSP00000405510.1" } ] } }, { "isoform_ac": "C9JNR9-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVF", "length": 19, "header": "tr|C9JNR9-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33631495, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000438788.1", "url": "https://www.ensembl.org/id/ENST00000438788.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000408385.1", "url": "https://www.ensembl.org/id/ENSP00000408385.1" } ] } }, { "isoform_ac": "C9JQD0-1", "url": "", "sequence": { "sequence": "MKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGT", "length": 107, "header": "tr|C9JQD0-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33622056, "end_pos": 33602334, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000417979.5", "url": "https://www.ensembl.org/id/ENST00000417979.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000402844.1", "url": "https://www.ensembl.org/id/ENSP00000402844.1" } ] } }, { "isoform_ac": "C9JZK8-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIDLSWMNPFHCMRQKFPWKLFRKIKEEKSKLFNFNFLLSQTSVG", "length": 197, "header": "tr|C9JZK8-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33589794, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445393.5", "url": "https://www.ensembl.org/id/ENST00000445393.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000399730.1", "url": "https://www.ensembl.org/id/ENSP00000399730.1" } ] } }, { "isoform_ac": "C9K0F7-1", "url": "", "sequence": { "sequence": "MKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCL", "length": 158, "header": "tr|C9K0F7-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33622056, "end_pos": 33599196, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000426935.5", "url": "https://www.ensembl.org/id/ENST00000426935.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000387660.1", "url": "https://www.ensembl.org/id/ENSP00000387660.1" } ] } }, { "isoform_ac": "F8WF64-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIENSTIA", "length": 183, "header": "tr|F8WF64-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33599269, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000429827.5", "url": "https://www.ensembl.org/id/ENST00000429827.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000399937.1", "url": "https://www.ensembl.org/id/ENSP00000399937.1" } ] } }, { "isoform_ac": "H7C0X3-1", "url": "", "sequence": { "sequence": "XRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQSDEHIPVFEARIFFGNC", "length": 111, "header": "tr|H7C0X3-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33597401, "end_pos": 33589747, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000441940.5", "url": "https://www.ensembl.org/id/ENST00000441940.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000397318.2", "url": "https://www.ensembl.org/id/ENSP00000397318.2" } ] } }, { "isoform_ac": "H7C2K1-1", "url": "", "sequence": { "sequence": "XQCLERFRPPIENSTIA", "length": 17, "header": "tr|H7C2K1-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33602265, "end_pos": 33599267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437996.5", "url": "https://www.ensembl.org/id/ENST00000437996.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000406423.1", "url": "https://www.ensembl.org/id/ENSP00000406423.1" } ] } }, { "isoform_ac": "H7C338-1", "url": "", "sequence": { "sequence": "HLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGGYIFQHSSYIFT", "length": 97, "header": "tr|H7C338-1|QORL1_HUMAN Computationally mapped isoform of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33603448, "end_pos": 33596179, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414079.5", "url": "https://www.ensembl.org/id/ENST00000414079.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000409387.1", "url": "https://www.ensembl.org/id/ENSP00000409387.1" } ] } }, { "isoform_ac": "H7C3I5-1", "url": "", "sequence": { "sequence": "XDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQVKKQKHRDVDTDSRTQQVAEQESHSGSLSPF", "length": 241, "header": "tr|H7C3I5-1|H7C3I5_HUMAN Computationally mapped isoform of Crystallin zeta like 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33622042, "end_pos": 33595434, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440526.5", "url": "https://www.ensembl.org/id/ENST00000440526.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000412087.1", "url": "https://www.ensembl.org/id/ENSP00000412087.1" } ] } }, { "isoform_ac": "H7C3S0-1", "url": "", "sequence": { "sequence": "XRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIENSTIA", "length": 96, "header": "tr|H7C3S0-1|H7C3S0_HUMAN Computationally mapped isoform of Crystallin zeta like 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=1 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33613560, "end_pos": 33599267, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452420.5", "url": "https://www.ensembl.org/id/ENST00000452420.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000413513.1", "url": "https://www.ensembl.org/id/ENSP00000413513.1" } ] } }, { "isoform_ac": "O95825-1", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF", "length": 349, "header": "sp|O95825-1|QORL1_HUMAN Isoform 1 of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33589825, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000381554.8", "url": "https://www.ensembl.org/id/ENST00000381554.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000370966.3", "url": "https://www.ensembl.org/id/ENSP00000370966.3" } ] } }, { "isoform_ac": "O95825-2", "url": "", "sequence": { "sequence": "MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLEDKQCLERFRPPIENSTIA", "length": 198, "header": "sp|O95825-2|QORL1_HUMAN Isoform 2 of Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2 CANONICAL=O95825-1" }, "locus": { "chromosome": "21", "start_pos": 33631551, "end_pos": 33599269, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420072.5", "url": "https://www.ensembl.org/id/ENST00000420072.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000416315.1", "url": "https://www.ensembl.org/id/ENSP00000416315.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1.", "journal": "Genomics", "date": "1999", "authors": "Kim M Y, Lee H K, Park J S, Park S H, Kwon H B, Soh J", "evidence": [ { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprot/O95825" } ], "reference": [ { "type": "PubMed", "id": "10191096", "url": "https://glygen.org/publication/PubMed/10191096" } ] }, { "title": "Human and yeast zeta-crystallins bind AU-rich elements in RNA.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2007", "authors": "Fernandez MR, Porte S, Crosas E, Barbera N, Farres J, Biosca JA, Pares X", "evidence": [ { "database": "RefSeq", "id": "NP_665857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665857" } ], "reference": [ { "type": "PubMed", "id": "17497241", "url": "https://glygen.org/publication/PubMed/17497241" } ] } ], "pathway": [ { "id": "hsa:9946", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9946", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q5XI39-1", "protein_name": "Crystallin zeta like 1", "gene_name": "Cryzl1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKGLYFQQSSTNEEVTFVFQEKENVSVTEDNFVRVQVKACALSHINTKLLAEMKMEKEFFPVGREVAGIVLDVGKKVSFFQPDDEVVGILPLDSEDPGLCEVIRVQEHYLVHKPEKVPWTEAAGVIRDGVRAYTALYYLSQLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTAHSLEDKQHLERLRPSLARVIDVSSGKVHVAERCLEETGGLGVDIVIDAGVRLYSKDDEPAVKQQLPHKHDIITLLSVGGHWITTEENLQLDPPDSHCLFLKGATVAFLNDEVWNLSNAQQGKYLCILKDVMEKLSAGVFRPLLDEPIPLYEAKVSMEVVQKSQERKKQVVQF", "length": 348 }, "evidence": [ { "id": "45925434", "url": "http://www.informatics.jax.org/homology/45925434", "database": "MGI" }, { "id": "O95825", "url": "https://omabrowser.org/oma/group/O95825/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q921W4-1", "protein_name": "Quinone oxidoreductase-like protein 1", "gene_name": "Cryzl1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKGLYFQQSSTNEEVTFVFQEKENVPVTEDNFVRVQVKACALSHINTKLLAEMKMEKDFFPVGREVSGIVLEVGRKVTFFQPDDEVVGILPLDSEDPGLCEVIRVHEHYLVHKPEKVSWTEAAGVIRDGVRACTALYYLSQLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTAHSLEDKQHLERLRPSIARVIDVSNGKVHVAESCLEETGGLGVDIVIDAGVRLYSKDDEPAVKLHLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATVAFLNDEVWNLSNAQQGKYLCILKDVMEKLSAGVFRPLLDEPIPLYEAKVSMEVVQKNQERKKQVVQF", "length": 348 }, "evidence": [ { "id": "45925434", "url": "http://www.informatics.jax.org/homology/45925434", "database": "MGI" }, { "id": "O95825", "url": "https://omabrowser.org/oma/group/O95825/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprot/O95825" } ], "pmid": "" }, { "name": "NADPH:quinone reductase activity", "id": "GO:0003960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003960", "evidence": [ { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprot/O95825" } ], "pmid": "" }, { "name": "NADP binding", "id": "GO:0050661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050661", "evidence": [ { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprot/O95825" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprot/O95825" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "quinone metabolic process", "id": "GO:1901661", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901661", "evidence": [ { "database": "UniProtKB", "id": "O95825", "url": "https://www.uniprot.org/uniprot/O95825" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 291, "end_pos": 293, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 291, "end_pos": 293 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }