{ "uniprot_canonical_ac": "O95754-1", "uniprot_ac": "O95754", "uniprot_id": "SEM4F_HUMAN", "mass": { "chemical_mass": 83511.0, "monoisotopic_mass": 83511.0 }, "refseq": { "ac": "NP_001258590", "name": "semaphorin-4F isoform 2 precursor", "summary": "This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" }, "gene_names": [ { "name": "SEMA4F", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95754", "id": "O95754" }, { "name": "M-SEMA; m-Sema-M; PRO2353; S4F; SEMAM; SEMAW", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590", "id": "NP_001258590" }, { "name": "SEMA4F", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590", "id": "NP_001258590" }, { "name": "SEMAM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95754", "id": "O95754" }, { "name": "SEMAW", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95754", "id": "O95754" } ], "protein_names": [ { "name": "Semaphorin-4F", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95754" }, { "name": "Sema M", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95754" }, { "name": "Sema W", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95754" }, { "name": "Semaphorin-M", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95754" }, { "name": "Semaphorin-W", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95754" }, { "name": "semaphorin M; semaphorin-4F; semaphorin-W; sema domain immunoglobulin domain transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 4F; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590", "id": "NP_001258590" }, { "name": "semaphorin-4F isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590", "id": "NP_001258590" } ], "function": [ { "annotation": "Data seems to indicate that SEMA4F is involved in tumour progression in breast cancer", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" }, { "database": "PubMed", "id": "21925246", "url": "https://glygen.org/publication/PubMed/21925246" } ] }, { "annotation": "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility candidate gene", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" }, { "database": "PubMed", "id": "11901358", "url": "https://glygen.org/publication/PubMed/11901358" } ] }, { "annotation": "Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754#function" }, { "database": "UniProtKB", "id": "Q9Z123", "url": "https://www.uniprot.org/uniprot/Q9Z123#function" }, { "database": "UniProtKB", "id": "Q9Z143", "url": "https://www.uniprot.org/uniprot/Q9Z143#function" } ] }, { "annotation": "Sema4F levels were strongly reduced in a panel of human neurofibromas, confirming the relevance of these findings to the human disease.", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" }, { "database": "PubMed", "id": "19056885", "url": "https://glygen.org/publication/PubMed/19056885" } ] }, { "annotation": "This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs755924968", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755924968" }, { "id": "rs755924968", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755924968" }, { "id": "rs755924968", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755924968#frequency_tab" }, { "id": "rs755924968", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755924968" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 133, "end_pos": 133, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NAS->SAS).", "chr_id": "2", "chr_pos": "74657893", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N133", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95754", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95754" } ], "glycoeffect": [], "start_pos": 263, "end_pos": 263, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "2", "chr_pos": "74673794", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R263", "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", 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"https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95754", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95754" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O95754", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95754" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "common_name": "Human" } ], "gene": [ { "name": "SEMA4F", "url": "https://www.uniprot.org/uniprot/O95754", "locus": { "chromosome": "2", "start_pos": 74683853, "end_pos": 74654228, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000135622", "url": "https://www.ensembl.org/id/ENSG00000135622" } ] } } ], "crossref": [ { "id": "ENSG00000135622", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135622", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O95754", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95754", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd11261", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11261", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "SEMA4F", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SEMA4F", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "10505", "url": "https://www.ncbi.nlm.nih.gov/gene/10505", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "10734", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=10734", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O95754", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95754*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027231", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027231", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047085", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047085", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:10505", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10505", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603706", "url": "http://www.omim.org/entry/603706", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O95754", "url": "https://www.nextprot.org/entry/NX_O95754", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "PRKIVWD", "url": "https://omabrowser.org/oma/group/PRKIVWD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5342713at2759", "url": "http://www.orthodb.org/?query=5342713at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11036:SF72", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11036:SF72", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01403", "url": "http://pfam.xfam.org/family/PF01403", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01437", "url": "http://pfam.xfam.org/family/PF01437", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19428", "url": "http://pfam.xfam.org/family/PF19428", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95754", "url": "https://pharos.nih.gov/targets/O95754", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95754", "url": "http://purl.obolibrary.org/obo/PR_O95754", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A087WYZ7", "url": "https://www.uniprot.org/uniprot/A0A087WYZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WYZ7-1", "url": "https://www.uniprot.org/uniprot/A0A087WYZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7Z931", "url": "https://www.uniprot.org/uniprot/B7Z931", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B7Z931-1", "url": "https://www.uniprot.org/uniprot/B7Z931-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JKW7", "url": "https://www.uniprot.org/uniprot/C9JKW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JKW7-1", "url": "https://www.uniprot.org/uniprot/C9JKW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9K0A1", "url": "https://www.uniprot.org/uniprot/C9K0A1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9K0A1-1", "url": "https://www.uniprot.org/uniprot/C9K0A1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WCP8", "url": "https://www.uniprot.org/uniprot/F8WCP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WCP8-1", "url": "https://www.uniprot.org/uniprot/F8WCP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WD61", "url": "https://www.uniprot.org/uniprot/F8WD61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WD61-1", "url": "https://www.uniprot.org/uniprot/F8WD61-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WEH3", "url": "https://www.uniprot.org/uniprot/F8WEH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WEH3-1", "url": "https://www.uniprot.org/uniprot/F8WEH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95754-1", "url": "https://www.uniprot.org/uniprot/O95754-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95754-2", "url": "https://www.uniprot.org/uniprot/O95754-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI", "length": 770, "header": "sp|O95754-1|SEM4F_HUMAN Isoform 1 of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=2 CANONICAL=O95754-1" }, "isoforms": [ { "isoform_ac": "A0A087WYZ7-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI", "length": 737, "header": "tr|A0A087WYZ7-1|A0A087WYZ7_HUMAN Computationally mapped isoform of Ssemaphorin 4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=1 SV=1 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74680206, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000611975.4", "url": "https://www.ensembl.org/id/ENST00000611975.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000482238.1", "url": "https://www.ensembl.org/id/ENSP00000482238.1" } ] } }, { "isoform_ac": "B7Z931-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEGGSSMLPL", "length": 127, "header": "tr|B7Z931-1|SEM4F_HUMAN Computationally mapped isoform of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=1 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74673480, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000446927.5", "url": "https://www.ensembl.org/id/ENST00000446927.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000413916.1", "url": "https://www.ensembl.org/id/ENSP00000413916.1" } ] } }, { "isoform_ac": "C9JKW7-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQ", "length": 178, "header": "tr|C9JKW7-1|SEM4F_HUMAN Computationally mapped isoform of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=1 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74674674, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000453930.5", "url": "https://www.ensembl.org/id/ENST00000453930.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000409141.1", "url": "https://www.ensembl.org/id/ENSP00000409141.1" } ] } }, { "isoform_ac": "C9K0A1-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLG", "length": 164, "header": "tr|C9K0A1-1|C9K0A1_HUMAN Computationally mapped isoform of Ssemaphorin 4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=1 SV=8 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74673497, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000434486.5", "url": "https://www.ensembl.org/id/ENST00000434486.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000407698.1", "url": "https://www.ensembl.org/id/ENSP00000407698.1" } ] } }, { "isoform_ac": "F8WCP8-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIGGSSMLPL", "length": 160, "header": "tr|F8WCP8-1|SEM4F_HUMAN Computationally mapped isoform of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=1 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74673480, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420077.5", "url": "https://www.ensembl.org/id/ENST00000420077.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000416490.1", "url": "https://www.ensembl.org/id/ENSP00000416490.1" } ] } }, { "isoform_ac": "F8WD61-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISVFRRKNRGGGYDPLKRCGRS", "length": 68, "header": "tr|F8WD61-1|F8WD61_HUMAN Computationally mapped isoform of Ssemaphorin 4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=4 SV=1 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74655325, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416236.5", "url": "https://www.ensembl.org/id/ENST00000416236.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000396703.1", "url": "https://www.ensembl.org/id/ENSP00000396703.1" } ] } }, { "isoform_ac": "F8WEH3-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISD", "length": 49, "header": "tr|F8WEH3-1|SEM4F_HUMAN Computationally mapped isoform of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=1 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74657566, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000458114.5", "url": "https://www.ensembl.org/id/ENST00000458114.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000413882.1", "url": "https://www.ensembl.org/id/ENSP00000413882.1" } ] } }, { "isoform_ac": "O95754-1", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI", "length": 770, "header": "sp|O95754-1|SEM4F_HUMAN Isoform 1 of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=2 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74680206, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000357877.7", "url": "https://www.ensembl.org/id/ENST00000357877.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000350547.2", "url": "https://www.ensembl.org/id/ENSP00000350547.2" } ] } }, { "isoform_ac": "O95754-2", "url": "", "sequence": { "sequence": "MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELGAGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENMKLYHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPKEPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQPSGVTALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALAKRGSGFGGFSPPFLLDPCPSPAHIRLTGAPLATCDETSI", "length": 615, "header": "sp|O95754-2|SEM4F_HUMAN Isoform 2 of Semaphorin-4F OS=Homo sapiens OX=9606 GN=SEMA4F PE=2 SV=2 CANONICAL=O95754-1" }, "locus": { "chromosome": "2", "start_pos": 74680206, "end_pos": 74654377, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000339773.9", "url": "https://www.ensembl.org/id/ENST00000339773.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000342675.5", "url": "https://www.ensembl.org/id/ENSP00000342675.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 133, "start_aa": "Asn", "end_pos": 133, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn133", "evidence": [ { "id": "O95754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95754#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 509, "start_aa": "Asn", "end_pos": 509, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn509", "evidence": [ { "id": "O95754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95754#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 64, "start_aa": "Asn", "end_pos": 64, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn64", "evidence": [ { "id": "O95754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95754#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 718, "end_pos": 718, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "site_lbl": "Ser718" }, { "start_pos": 720, "end_pos": 720, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "site_lbl": "Ser720" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1999", "authors": "Encinas JA, Kikuchi K, Chedotal A, de Castro F, Goodman CS, Kimura T", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "reference": [ { "type": "PubMed", "id": "10051670", "url": "https://glygen.org/publication/PubMed/10051670" } ] }, { "title": "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.", "journal": "Genome Res.", "date": "2001", "authors": "Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "reference": [ { "type": "PubMed", "id": "11230166", "url": "https://glygen.org/publication/PubMed/11230166" } ] }, { "title": "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1.", "journal": "Psychiatric genetics", "date": "2002", "authors": "Francks C, Fisher SE, Olson RK, Pennington BF, Smith SD, DeFries JC, Monaco AP", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" } ], "reference": [ { "type": "PubMed", "id": "11901358", "url": "https://glygen.org/publication/PubMed/11901358" } ] }, { "title": "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Katoh H, Harada A, Mori K, Negishi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "11940653", "url": "https://glygen.org/publication/PubMed/11940653" } ] }, { "title": "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.", "journal": "Current biology : CB", "date": "2003", "authors": "Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "12842009", "url": "https://glygen.org/publication/PubMed/12842009" } ] }, { "title": "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Harada A, Katoh H, Negishi M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "15738000", "url": "https://glygen.org/publication/PubMed/15738000" } ] }, { "title": "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.", "journal": "DNA Res.", "date": "2005", "authors": "Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "reference": [ { "type": "PubMed", "id": "16303743", "url": "https://glygen.org/publication/PubMed/16303743" } ] }, { "title": "Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Li YH, Ghavampur S, Bondallaz P, Will L, Grenningloh G, Puschel AW", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "18996843", "url": "https://glygen.org/publication/PubMed/18996843" } ] }, { "title": "NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F.", "journal": "Genes & development", "date": "2008", "authors": "Parrinello S, Noon LA, Harrisingh MC, Wingfield Digby P, Rosenberg LH, Cremona CA, Echave P, Flanagan AM, Parada LF, Lloyd AC", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" } ], "reference": [ { "type": "PubMed", "id": "19056885", "url": "https://glygen.org/publication/PubMed/19056885" } ] }, { "title": "The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.", "journal": "PloS one", "date": "2010", "authors": "Goh LL, Manser E", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "20811643", "url": "https://glygen.org/publication/PubMed/20811643" } ] }, { "title": "Semaphorin-plexin signalling genes associated with human breast tumourigenesis.", "journal": "Gene", "date": "2011", "authors": "Gabrovska PN, Smith RA, Tiang T, Weinstein SR, Haupt LM, Griffiths LR", "evidence": [ { "database": "RefSeq", "id": "NP_001258590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258590" } ], "reference": [ { "type": "PubMed", "id": "21925246", "url": "https://glygen.org/publication/PubMed/21925246" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.", "journal": "Neural development", "date": "2016", "authors": "Gladwyn-Ng I, Huang L, Ngo L, Li SS, Qu Z, Vanyai HK, Cullen HD, Davis JM, Heng JI", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "26969432", "url": "https://glygen.org/publication/PubMed/26969432" } ] }, { "title": "Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.", "journal": "Nature cell biology", "date": "2020", "authors": "Bagci H, Sriskandarajah N, Robert A, Boulais J, Elkholi IE, Tran V, Lin ZY, Thibault MP, Dube N, Faubert D, Hipfner DR, Gingras AC, Cote JF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "31871319", "url": "https://glygen.org/publication/PubMed/31871319" } ] }, { "title": "Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.", "journal": "Molecular and cellular biology", "date": "1996", "authors": "Foster R, Hu KQ, Lu Y, Nolan KM, Thissen J, Settleman J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9696264", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264" } ], "reference": [ { "type": "PubMed", "id": "8649376", "url": "https://glygen.org/publication/PubMed/8649376" } ] } ], "pathway": [ { "id": 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"O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "pmid": "" }, { "name": "negative chemotaxis", "id": "GO:0050919", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050919", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": "https://www.uniprot.org/uniprot/O95754" } ], "pmid": "" }, { "name": "retinal ganglion cell axon guidance", "id": "GO:0031290", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031290", "evidence": [ { "database": "UniProtKB", "id": "O95754", "url": 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