{ "uniprot_canonical_ac": "O95671-1", "uniprot_ac": "O95671", "uniprot_id": "ASML_HUMAN", "mass": { "chemical_mass": 68857.0, "monoisotopic_mass": 68857.0 }, "refseq": { "ac": "NP_001166944", "name": "probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 2", "summary": "The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944" }, "gene_names": [ { "name": "ASMTL", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95671", "id": "O95671" }, { "name": "ASMTLX; ASMTLY; ASTML", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944", "id": "NP_001166944" }, { "name": "ASMTL", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944", "id": "NP_001166944" } ], "protein_names": [ { "name": "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95671" }, { "name": "Nucleoside triphosphate pyrophosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95671" }, { "name": "Nucleotide PPase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95671" }, { "name": "Nucleotide pyrophosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95671" }, { "name": "acetylserotonin N-methyltransferase-like; probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; N-acetylserotonin O-methyltransferase-like protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944", "id": "NP_001166944" }, { "name": "probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944", "id": "NP_001166944" } ], "function": [ { "annotation": "Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671#function" }, { "database": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "annotation": "The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001166944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O95671", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95671" } ], "glycoeffect": [], "start_pos": 244, "end_pos": 244, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "G", "sequence_mut": "V", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "X", "chr_pos": "1427900", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "G244", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "O95671", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95671" } ], "glycoeffect": [], "start_pos": 253, "end_pos": 253, "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%). In dbSNP: rs754253340.", "chr_id": "X", "chr_pos": "1427874", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A253", "keywords": [ "biomuta", "somatic", "cancer" ] } ], "mutagenesis": [ { "start_pos": 179, "end_pos": 179, "sequence_org": "Q", "sequence_mut": "A", "comment": "Loss of pyrophosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "start_pos": 179, "end_pos": 179, "sequence_org": "Q", "sequence_mut": "E", "comment": "Strong decrease in pyrophosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "start_pos": 19, "end_pos": 19, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of pyrophosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "start_pos": 21, "end_pos": 21, "sequence_org": "S", "sequence_mut": "A", "comment": "Loss of pyrophosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "start_pos": 23, "end_pos": 23, "sequence_org": "R", "sequence_mut": "A", "comment": "Decrease in pyrophosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "start_pos": 24, "end_pos": 24, "sequence_org": "R", "sequence_mut": "A", 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O95671", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95671" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95671" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" 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[ "Protein Classification" ] }, { "id": "cd02440", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02440", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "ASMTL", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASMTL", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "8623", "url": "https://www.ncbi.nlm.nih.gov/gene/8623", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "751", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=751", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O95671", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95671*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001077", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001077", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003697", 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"http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43213", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43213:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43213:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2P5X", "url": "https://www.rcsb.org/structure/2P5X", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XI4", "url": "https://www.rcsb.org/structure/6XI4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XI5", "url": "https://www.rcsb.org/structure/6XI5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00891", "url": "http://pfam.xfam.org/family/PF00891", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02545", "url": "http://pfam.xfam.org/family/PF02545", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16864", "url": "http://pfam.xfam.org/family/PF16864", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95671", "url": "https://pharos.nih.gov/targets/O95671", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95671", "url": "http://purl.obolibrary.org/obo/PR_O95671", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001166944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166944", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "27762", "url": "https://www.rhea-db.org/rhea/27762", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "28534", "url": "https://www.rhea-db.org/rhea/28534", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "29395", "url": "https://www.rhea-db.org/rhea/29395", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "58732", "url": "https://www.rhea-db.org/rhea/58732", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "58736", "url": "https://www.rhea-db.org/rhea/58736", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "58740", "url": "https://www.rhea-db.org/rhea/58740", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95671-1", "url": "https://www.uniprot.org/uniprot/O95671-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95671-2", "url": "https://www.uniprot.org/uniprot/O95671-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95671-3", "url": "https://www.uniprot.org/uniprot/O95671-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTETANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTVFDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFHQVQVVHLGGVLDAILATKVAP", "length": 621, "header": "sp|O95671-1|ASML_HUMAN Isoform 1 of Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3 CANONICAL=O95671-1" }, "isoforms": [ { "isoform_ac": "O95671-1", "url": "", "sequence": { "sequence": "MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTETANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTVFDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFHQVQVVHLGGVLDAILATKVAP", "length": 621, "header": "sp|O95671-1|ASML_HUMAN Isoform 1 of Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3 CANONICAL=O95671-1" }, "locus": { "chromosome": "X", "start_pos": 1452840, "end_pos": 1403272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000381317.9", "url": "https://www.ensembl.org/id/ENST00000381317.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000370718.3", "url": "https://www.ensembl.org/id/ENSP00000370718.3" } ] } }, { "isoform_ac": "O95671-2", "url": "", "sequence": { "sequence": "MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRLYQTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTETANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTVFDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFHQVQVVHLGGVLDAILATKVAP", "length": 605, "header": "sp|O95671-2|ASML_HUMAN Isoform 2 of Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3 CANONICAL=O95671-1" }, "locus": { "chromosome": "Y", "start_pos": 1452840, "end_pos": 1403272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000711196.1", "url": "https://www.ensembl.org/id/ENST00000711196.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000518599.1", "url": "https://www.ensembl.org/id/ENSP00000518599.1" } ] } }, { "isoform_ac": "O95671-3", "url": "", "sequence": { "sequence": "METAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTETANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTVFDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFHQVQVVHLGGVLDAILATKVAP", "length": 563, "header": "sp|O95671-3|ASML_HUMAN Isoform 3 of Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3 CANONICAL=O95671-1" }, "locus": { "chromosome": "X", "start_pos": 1442236, "end_pos": 1403272, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000534940.6", "url": "https://www.ensembl.org/id/ENST00000534940.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000446410.1", "url": "https://www.ensembl.org/id/ENSP00000446410.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O95671", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95671" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 21, "end_pos": 21, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ], "site_lbl": "Ser21" }, { "start_pos": 223, "end_pos": 223, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O95671", "url": "http://phospho.elm.eu.org/byAccession/O95671.html" } ], "site_lbl": "Ser223" }, { "start_pos": 228, "end_pos": 228, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "phospho.ELM", "id": "O95671", "url": "http://phospho.elm.eu.org/byAccession/O95671.html" } ], "site_lbl": "Ser228" }, { "start_pos": 234, "end_pos": 234, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "phospho.ELM", "id": "O95671", "url": "http://phospho.elm.eu.org/byAccession/O95671.html" } ], "site_lbl": "Thr234" }, { "start_pos": 239, "end_pos": 239, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "18318008", "url": "https://glygen.org/publication/PubMed/18318008" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" }, { "database": "phospho.ELM", "id": "O95671", "url": "http://phospho.elm.eu.org/byAccession/O95671.html" } ], "site_lbl": "Ser239" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" } ], "site_lbl": "Ser421" }, { "start_pos": 424, "end_pos": 424, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr424" }, { "start_pos": 517, "end_pos": 517, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser517" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.", "journal": "Cell", "date": "2006", "authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ] }, { "title": "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.", "journal": "Proteomics", "date": "2008", "authors": "Han G, Ye M, Zhou H, Jiang X, Feng S, Jiang X, Tian R, Wan D, Zou H, Gu J", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" } ], "reference": [ { "type": "PubMed", "id": "18318008", "url": "https://glygen.org/publication/PubMed/18318008" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Molecular cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "O95671-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95671", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95671" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.", "journal": "Chemistry & biology", "date": "2013", "authors": "Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "reference": [ { "type": "PubMed", "id": "24210219", "url": "https://glygen.org/publication/PubMed/24210219" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" }, { "database": "iPTMnet", "id": "O95671", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95671" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95671", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95671" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95671", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95671" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL.", "journal": "Hum. Mol. Genet.", "date": "1998", "authors": "Ried K, Rao E, Schiebel K, Rappold GA", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "reference": [ { "type": "PubMed", "id": "9736779", "url": "https://glygen.org/publication/PubMed/9736779" } ] } ], "pathway": [ { "id": "hsa:8623", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8623", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "nucleotide metabolic process", "id": "GO:0009117", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009117", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "S-adenosylmethionine-dependent methyltransferase activity", "id": "GO:0008757", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008757", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" }, { "name": "O-methyltransferase activity", "id": "GO:0008171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008171", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" }, { "name": "nucleoside triphosphate diphosphatase activity", "id": "GO:0047429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047429", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" }, { "name": "UTP diphosphatase activity", "id": "GO:0036221", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036221", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" }, { "name": "dTTP diphosphatase activity", "id": "GO:0036218", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036218", "evidence": [ { "database": "UniProtKB", "id": "O95671", "url": "https://www.uniprot.org/uniprot/O95671" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 448, "end_pos": 450, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "27762", "name": "", "equation": "CTP + H2O = CMP + diphosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q924C3-1", "O95671-1", "P22413-1", "P06802-1" ], "evidence": [ { "id": "27762", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/27762" } ] }, { "id": "28534", "name": "", "equation": "dTTP + H2O = diphosphate + dTMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95671-1", "Q99210-1" ], "evidence": [ { "id": "28534", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/28534" } ] }, { "id": "29395", "name": "", "equation": "H2O + UTP = diphosphate + H(+) + UMP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q924C3-1", "O95671-1", "P22413-1", "P06802-1", "Q99210-1" ], "evidence": [ { "id": "29395", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29395" } ] }, { "id": "58732", "name": "", "equation": "5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)", 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"ASMTL", "activity": [ { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "O95671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95671" } ] }, { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "O95671", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95671" } ] } ] }, { "uniprot_ac": "P06802", "gene_name": "Enpp1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P06802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06802" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "P06802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06802" } ] } ] }, { "uniprot_ac": "P22413", "gene_name": "ENPP1", "activity": [ { "ec_number": "3.1.4.1", 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