{ "uniprot_canonical_ac": "O95573-1", "uniprot_ac": "O95573", "uniprot_id": "ACSL3_HUMAN", "mass": { "chemical_mass": 80420.0, "monoisotopic_mass": 80420.0 }, "refseq": { "ac": "NP_004448", "name": "fatty acid CoA ligase Acsl3", "summary": "The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" }, "gene_names": [ { "name": "ACSL3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95573", "id": "O95573" }, { "name": "ACS3; FACL3; LACS 3; LACS3; PRO2194", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448", "id": "NP_004448" }, { "name": "ACS3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95573", "id": "O95573" }, { "name": "ACSL3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448", "id": "NP_004448" }, { "name": "FACL3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95573", "id": "O95573" }, { "name": "LACS3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95573", "id": "O95573" } ], "protein_names": [ { "name": "Fatty acid CoA ligase Acsl3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95573" }, { "name": "6.2.1.15", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "6.2.1.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "6.2.1.3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "Arachidonate--CoA ligase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "LACS 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "Long-chain acyl-CoA synthetase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "Long-chain-fatty-acid--CoA ligase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "Medium-chain acyl-CoA ligase Acsl3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95573" }, { "name": "fatty acid CoA ligase Acsl3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448", "id": "NP_004448" }, { "name": "lignoceroyl-CoA synthase; fatty-acid-Coenzyme A ligase, long-chain 3; long-chain-fatty-acid--CoA ligase 3; long-chain acyl-CoA synthetase 3; arachidonate--CoA ligase; medium-chain acyl-CoA ligase Acsl3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448", "id": "NP_004448" } ], "function": [ { "annotation": "Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" }, { "database": "PubMed", "id": "35182729", "url": "https://glygen.org/publication/PubMed/35182729" } ] }, { "annotation": "Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573#function" }, { "database": "PubMed", "id": "22633490", "url": "https://glygen.org/publication/PubMed/22633490" }, { "database": "UniProtKB", "id": "Q63151", "url": "https://www.uniprot.org/uniprot/Q63151#function" }, { "database": "PubMed", "id": "18003621", "url": "https://glygen.org/publication/PubMed/18003621" } ] }, { "annotation": "Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases.", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" }, { "database": "PubMed", "id": "32286604", "url": "https://glygen.org/publication/PubMed/32286604" } ] }, { "annotation": "Metabolic enzyme ACSL3 is a prognostic biomarker and correlates with anticancer effectiveness of statins in non-small cell lung cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" }, { "database": "PubMed", "id": "33030783", "url": "https://glygen.org/publication/PubMed/33030783" } ] }, { "annotation": "The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" }, { "database": "PubMed", "id": "32034305", "url": "https://glygen.org/publication/PubMed/32034305" } ] }, { "annotation": "The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" } ] }, { "annotation": "[Research advances on the role of ACSL3 in the atherosclerosis].", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" }, { "database": "PubMed", "id": "37583046", "url": "https://glygen.org/publication/PubMed/37583046" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O95573", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95573" } ], "glycoeffect": [], "start_pos": 232, "end_pos": 232, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "2", "chr_pos": "222919092", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R232", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:1793", "recommended_name": { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic cancer", "description": "An endocrine gland cancer located_in the pancreas." }, "synonyms": [ { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "Ca tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of body of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of head of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "malignant neoplasm of tail of pancreas", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreas neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic neoplasm", "description": "" }, { "id": "DOID:1793", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1793", "name": "pancreatic tumor", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "86.92", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "91.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "94.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "82.97", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "92.68", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "94.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "78.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "92.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "90.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "90.84", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "96.38", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "96.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95573", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95573" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": 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"http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95573" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O95573", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95573" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95573", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95573" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O95573", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95573" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "common_name": "Human" } ], "gene": [ { "name": "ACSL3", "url": "https://www.uniprot.org/uniprot/O95573", "locus": { "chromosome": "2", "start_pos": 222944639, "end_pos": 222860942, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000123983", "url": "https://www.ensembl.org/id/ENSG00000123983" } ] } } ], "crossref": [ { "id": "ENSG00000123983", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000123983", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O95573", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95573", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "6.2.1.3", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.3&UniProtAcc=O95573", "database": "BRENDA", 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"GEGEKMP", "url": "https://omabrowser.org/oma/group/GEGEKMP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "443463at2759", "url": "http://www.orthodb.org/?query=443463at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43272", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43272", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43272:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43272:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "http://pfam.xfam.org/family/PF00501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95573", "url": "https://pharos.nih.gov/targets/O95573", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95573", "url": "http://purl.obolibrary.org/obo/PR_O95573", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-434313", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-434313", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "15421", "url": "https://www.rhea-db.org/rhea/15421", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19713", "url": "https://www.rhea-db.org/rhea/19713", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "30751", "url": "https://www.rhea-db.org/rhea/30751", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33607", "url": "https://www.rhea-db.org/rhea/33607", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33615", "url": "https://www.rhea-db.org/rhea/33615", 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"database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "46208", "url": "https://www.rhea-db.org/rhea/46208", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48340", "url": "https://www.rhea-db.org/rhea/48340", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52012", "url": "https://www.rhea-db.org/rhea/52012", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52016", "url": "https://www.rhea-db.org/rhea/52016", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52108", "url": "https://www.rhea-db.org/rhea/52108", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52112", "url": "https://www.rhea-db.org/rhea/52112", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "52116", "url": "https://www.rhea-db.org/rhea/52116", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "67848", "url": "https://www.rhea-db.org/rhea/67848", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A7P0T8L6", "url": "https://www.uniprot.org/uniprot/A0A7P0T8L6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T8L6-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T8L6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T905", "url": "https://www.uniprot.org/uniprot/A0A7P0T905", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T905-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T905-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TA76", "url": "https://www.uniprot.org/uniprot/A0A7P0TA76", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TA76-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TA76-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TB52", "url": "https://www.uniprot.org/uniprot/A0A7P0TB52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TB52-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TB52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TBB1", "url": "https://www.uniprot.org/uniprot/A0A7P0TBB1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TBB1-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TBB1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TBL9", "url": "https://www.uniprot.org/uniprot/A0A7P0TBL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TBL9-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TBL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JC11", "url": "https://www.uniprot.org/uniprot/C9JC11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JC11-1", "url": "https://www.uniprot.org/uniprot/C9JC11-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F5GWH2", "url": "https://www.uniprot.org/uniprot/F5GWH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F5GWH2-1", "url": "https://www.uniprot.org/uniprot/F5GWH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BYZ7", "url": "https://www.uniprot.org/uniprot/H7BYZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7BYZ7-1", "url": "https://www.uniprot.org/uniprot/H7BYZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95573-1", "url": "https://www.uniprot.org/uniprot/O95573-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK", "length": 720, "header": "sp|O95573-1|ACSL3_HUMAN Isoform 1 of Fatty acid CoA ligase Acsl3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3 CANONICAL=O95573-1" }, "isoforms": [ { "isoform_ac": "A0A7P0T8L6-1", "url": "", "sequence": { "sequence": "MLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK", "length": 568, "header": "tr|A0A7P0T8L6-1|A0A7P0T8L6_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222941651, "end_pos": 222916397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000681009.1", "url": "https://www.ensembl.org/id/ENST00000681009.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505150.1", "url": "https://www.ensembl.org/id/ENSP00000505150.1" } ] } }, { "isoform_ac": "A0A7P0T905-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEGSVLHGQRLECDARRFFGCGTTILAEWEHH", "length": 518, "header": "tr|A0A7P0T905-1|A0A7P0T905_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222928897, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680525.1", "url": "https://www.ensembl.org/id/ENST00000680525.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504977.1", "url": "https://www.ensembl.org/id/ENSP00000504977.1" } ] } }, { "isoform_ac": "A0A7P0TA76-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQRGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK", "length": 712, "header": "tr|A0A7P0TA76-1|A0A7P0TA76_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222941651, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679545.1", "url": "https://www.ensembl.org/id/ENST00000679545.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505933.1", "url": "https://www.ensembl.org/id/ENSP00000505933.1" } ] } }, { "isoform_ac": "A0A7P0TB52-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSVPWREVKKIKPSFLLPWYPYLPVPQQGKLHRTTPEEWGVKKWQ", "length": 659, "header": "tr|A0A7P0TB52-1|A0A7P0TB52_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222933635, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680420.1", "url": "https://www.ensembl.org/id/ENST00000680420.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506382.1", "url": "https://www.ensembl.org/id/ENSP00000506382.1" } ] } }, { "isoform_ac": "A0A7P0TBB1-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK", "length": 695, "header": "tr|A0A7P0TBB1-1|A0A7P0TBB1_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222941651, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679541.1", "url": "https://www.ensembl.org/id/ENST00000679541.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506590.1", "url": "https://www.ensembl.org/id/ENSP00000506590.1" } ] } }, { "isoform_ac": "A0A7P0TBL9-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMERKMSTLDICLWPMF", "length": 283, "header": "tr|A0A7P0TBL9-1|ACSL3_HUMAN Computationally mapped isoform of Fatty acid CoA ligase Acsl3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222922751, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680736.1", "url": "https://www.ensembl.org/id/ENST00000680736.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506668.1", "url": "https://www.ensembl.org/id/ENSP00000506668.1" } ] } }, { "isoform_ac": "C9JC11-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTL", "length": 88, "header": "tr|C9JC11-1|ACSL3_HUMAN Computationally mapped isoform of Fatty acid CoA ligase Acsl3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222909036, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000413316.1", "url": "https://www.ensembl.org/id/ENST00000413316.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000416913.1", "url": "https://www.ensembl.org/id/ENSP00000416913.1" } ] } }, { "isoform_ac": "F5GWH2-1", "url": "", "sequence": { "sequence": "MLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGL", "length": 141, "header": "tr|F5GWH2-1|F5GWH2_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=1 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222921353, "end_pos": 222916397, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000540115.1", "url": "https://www.ensembl.org/id/ENST00000540115.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000441643.1", "url": "https://www.ensembl.org/id/ENSP00000441643.1" } ] } }, { "isoform_ac": "H7BYZ7-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDRWIL", "length": 434, "header": "tr|H7BYZ7-1|H7BYZ7_HUMAN Computationally mapped isoform of long-chain-fatty-acid--CoA ligase OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222930630, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000407441.5", "url": "https://www.ensembl.org/id/ENST00000407441.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000385157.4", "url": "https://www.ensembl.org/id/ENSP00000385157.4" } ] } }, { "isoform_ac": "O95573-1", "url": "", "sequence": { "sequence": "MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK", "length": 720, "header": "sp|O95573-1|ACSL3_HUMAN Isoform 1 of Fatty acid CoA ligase Acsl3 OS=Homo sapiens OX=9606 GN=ACSL3 PE=1 SV=3 CANONICAL=O95573-1" }, "locus": { "chromosome": "2", "start_pos": 222941651, "end_pos": 222908773, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680395.1", "url": "https://www.ensembl.org/id/ENST00000680395.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505793.1", "url": "https://www.ensembl.org/id/ENSP00000505793.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O95573", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95573" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [ { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr107" }, { "start_pos": 593, "end_pos": 593, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" }, { "database": "phospho.ELM", "id": "O95573", "url": "http://phospho.elm.eu.org/byAccession/O95573.html" } ], "site_lbl": "Ser593" }, { "start_pos": 683, "end_pos": 683, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" } ], "site_lbl": "Ser683" }, { "start_pos": 688, "end_pos": 688, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "phospho.ELM", "id": "O95573", "url": "http://phospho.elm.eu.org/byAccession/O95573.html" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr688" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors.", "journal": "The Biochemical journal", "date": "1999", "authors": "Malhotra KT, Malhotra K, Lubin BH, Kuypers FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "10548543", "url": "https://glygen.org/publication/PubMed/10548543" } ] }, { "title": "Very long-chain acyl-CoA synthetases. Human `bubblegum` represents a new family of proteins capable of activating very long-chain fatty acids.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "10954726", "url": "https://glygen.org/publication/PubMed/10954726" } ] }, { "title": "Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene.", "journal": "Gene", "date": "2001", "authors": "Minekura H, Kang MJ, Inagaki Y, Suzuki H, Sato H, Fujino T, Yamamoto TT", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "reference": [ { "type": "PubMed", "id": "11707336", "url": "https://glygen.org/publication/PubMed/11707336" } ] }, { "title": "FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.", "journal": "Nature genetics", "date": "2002", "authors": "Meloni I, Muscettola M, Raynaud M, Longo I, Bruttini M, Moizard MP, Gomot M, Chelly J, des Portes V, Fryns JP, Ropers HH, Magi B, Bellan C, Volpi N, Yntema HG, Lewis SE, Schaffer JE, Renieri A", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "11889465", "url": "https://glygen.org/publication/PubMed/11889465" } ] }, { "title": "Identification and expression of mammalian long-chain PUFA elongation enzymes.", "journal": "Lipids", "date": "2002", "authors": "Leonard AE, Kelder B, Bobik EG, Chuang LT, Lewis CJ, Kopchick JJ, Mukerji P, Huang YS", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12371743", "url": "https://glygen.org/publication/PubMed/12371743" } ] }, { "title": "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Moon YA, Horton JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12482854", "url": "https://glygen.org/publication/PubMed/12482854" } ] }, { "title": "A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients.", "journal": "Journal of medical genetics", "date": "2003", "authors": "Longo I, Frints SG, Fryns JP, Meloni I, Pescucci C, Ariani F, Borghgraef M, Raynaud M, Marynen P, Schwartz C, Renieri A, Froyen G", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12525535", "url": "https://glygen.org/publication/PubMed/12525535" } ] }, { "title": "The acyl-CoA synthetase `bubblegum` (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation..", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Pei Z, Oey NA, Zuidervaart MM, Jia Z, Li Y, Steinberg SJ, Smith KD, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "12975357", "url": "https://glygen.org/publication/PubMed/12975357" } ] }, { "title": "Large-scale characterization of HeLa cell nuclear phosphoproteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" } ], "reference": [ { "type": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ] }, { "title": "Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Pei Z, Fraisl P, Berger J, Jia Z, Forss-Petter S, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "15469937", "url": "https://glygen.org/publication/PubMed/15469937" } ] }, { "title": "Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion.", "journal": "Diabetes", "date": "2005", "authors": "Noushmehr H, D'Amico E, Farilla L, Hui H, Wawrowsky KA, Mlynarski W, Doria A, Abumrad NA, Perfetti R", "evidence": [ { "database": "Reactome", "id": "R-HSA-434313", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-434313" } ], "reference": [ { "type": "PubMed", "id": "15677505", "url": "https://glygen.org/publication/PubMed/15677505" } ] }, { "title": "Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Grayson C, Molday RS", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "16036915", "url": "https://glygen.org/publication/PubMed/16036915" } ] }, { "title": "The second member of the human and murine bubblegum family is a testis- and brainstem-specific acyl-CoA synthetase.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Pei Z, Jia Z, Watkins PA", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "16371355", "url": "https://glygen.org/publication/PubMed/16371355" } ] }, { "title": "Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7.", "journal": "Journal of lipid research", "date": "2007", "authors": "Fujimoto Y, Itabe H, Kinoshita T, Homma KJ, Onoduka J, Mori M, Yamaguchi S, Makita M, Higashi Y, Yamashita A, Takano T", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "17379924", "url": "https://glygen.org/publication/PubMed/17379924" } ] }, { "title": "Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing.", "journal": "Gastroenterology", "date": "2007", "authors": "Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knuchel R, Kopitz J", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "17681178", "url": "https://glygen.org/publication/PubMed/17681178" } ] }, { "title": "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome.", "journal": "Journal of lipid research", "date": "2007", "authors": "Watkins PA, Maiguel D, Jia Z, Pevsner J", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "17762044", "url": "https://glygen.org/publication/PubMed/17762044" } ] }, { "title": "Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Yao H, Ye J", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" }, { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "18003621", "url": "https://glygen.org/publication/PubMed/18003621" } ] }, { "title": "Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.", "journal": "FEBS letters", "date": "2008", "authors": "Ikeda M, Kanao Y, Yamanaka M, Sakuraba H, Mizutani Y, Igarashi Y, Kihara A", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "18554506", "url": "https://glygen.org/publication/PubMed/18554506" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Molecular cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": 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Takahashi H, Kitazawa H, Miyamoto Y, Nagumo A, Tang C, Dean D, Nagase T, Sato N, Tokita S", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "19505953", "url": "https://glygen.org/publication/PubMed/19505953" } ] }, { "title": "Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism.", "journal": "Cancer research", "date": "2009", "authors": "Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "19826053", "url": "https://glygen.org/publication/PubMed/19826053" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O95573", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95573" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A", "evidence": [ { "database": "Reactome", "id": "R-HSA-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-75876" } ], "reference": [ { "type": "PubMed", "id": "20937905", "url": "https://glygen.org/publication/PubMed/20937905" } ] }, { 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Gomez de Cedron M, Reglero G, Casado E, Sereno M, Ramirez de Molina A", "evidence": [ { "database": "RefSeq", "id": "NP_004448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004448" } ], "reference": [ { "type": "PubMed", "id": "33030783", "url": "https://glygen.org/publication/PubMed/33030783" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95573", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95573" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95573", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95573" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": 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"http://www.informatics.jax.org/homology/45921268", "database": "MGI" }, { "id": "O95573", "url": "https://omabrowser.org/oma/group/O95573/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "mitochondrial outer membrane", "id": "GO:0005741", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "lipid droplet", "id": "GO:0005811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "long-chain fatty acid metabolic process", "id": "GO:0001676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001676", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA biosynthetic process", "id": "GO:0035338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035338", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "very-low-density lipoprotein particle assembly", "id": "GO:0034379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034379", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "positive regulation of Golgi to plasma membrane protein transport", "id": "GO:0042998", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042998", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "long-chain fatty acid import into cell", "id": "GO:0044539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044539", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "positive regulation of secretion", "id": "GO:0051047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051047", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylcholine biosynthetic process", "id": "GO:2001247", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001247", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "long-chain fatty-acyl-CoA metabolic process", "id": "GO:0035336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035336", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "long-chain fatty acid-CoA ligase activity", "id": "GO:0004467", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004467", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "arachidonate-CoA ligase activity", "id": "GO:0047676", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047676", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "medium-chain fatty acid-CoA ligase activity", "id": "GO:0031956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031956", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" }, { "name": "palmitoyl-CoA ligase activity", "id": "GO:0090433", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090433", "evidence": [ { "database": "UniProtKB", "id": "O95573", "url": "https://www.uniprot.org/uniprot/O95573" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 203, "end_pos": 205, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15421", "name": "", "equation": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "A1L1K7-1", "Q63151-1", "P18163-1", "P33124-1", "Q924N5-1", "P97524-1", "P97849-1", "Q9ES38-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q96GR2-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P5-1", "Q9Y2P4-1", "Q5K4L6-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q99PU5-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q60714-1", "Q91VE0-1", "E9Q9W4-1", "O88561-1", "Q4LDG0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1", "Q1ZXQ4-1", "Q55DR6-1", "Q9VVT8-1", "Q9V3U0-1", "Q9V3S9-1", "A0A0B4KFE4-1" ], "evidence": [ { "id": "15421", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15421" } ] }, { "id": "19713", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "A1L1K7-1", "Q63151-1", "P18163-1", "P33124-1", "P97524-1", "P97849-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6PCB7-1", "Q6P1M0-1", "Q9Y2P4-1", "Q5K4L6-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q60714-1", "E9Q9W4-1", "O88561-1", "Q91VE0-1", "Q9VVT8-1" ], "evidence": [ { "id": "19713", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19713" } ] }, { "id": "30751", "name": "", "equation": "ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "P18163-1", "A1L1K7-1", "P33124-1", "Q924N5-1", "P97524-1", "Q63151-1", "Q9UKU0-4", "P33121-1", "O60488-1", "Q08AH1-1", "Q96GR2-1", "Q5FVE4-1", "Q9ULC5-1", "O14975-1", "Q6P1M0-1", "Q5K4L6-1", "O95573-1", "Q91WC3-1", "Q91VA0-1", "Q8JZR0-1", "P41216-1", "Q2XU92-1", "Q99PU5-1", "Q9QUJ7-1", "O35488-1", "Q9CZW4-1", "O88561-1", "Q91VE0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1", "Q9VVT8-1" ], "evidence": [ { "id": "30751", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/30751" } ] }, { "id": "33607", "name": "", "equation": "(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1L1K7-1", "Q63151-1", "P18163-1", "P97524-1", "O88813-1", "Q5FVE4-1", "P33121-1", "Q6P1M0-1", "Q9Y2P4-1", "Q5K4L6-1", "O95573-1", "O14975-1", "Q9ULC5-1", "Q2XU92-1", "P41216-1", "Q9CZW4-1", "E9Q9W4-1", "O88561-1", "Q91VE0-1", "O35488-1", "Q8JZR0-1", "P30624-1", "P39002-1", "P39518-1", "P47912-1" ], "evidence": [ { "id": "33607", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33607" } ] }, { "id": "33615", "name": "", "equation": "ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES38-1", "Q63151-1", "Q9Y2P5-1", "O95573-1", "Q4LDG0-1", "Q9CZW4-1", "P30624-1" ], "evidence": [ { "id": "33615", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33615" } ] }, { "id": "33619", "name": "", "equation": "ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63151-1", "Q08AH1-1", "O95573-1", "Q91VA0-1", "Q9CZW4-1", "P30624-1", "P39518-1" ], "evidence": [ { "id": "33619", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33619" } ] }, { "id": "33623", "name": "", "equation": "ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7TN78-1", "Q63151-1", "P0C7M7-1", "Q08AH1-1", "O95573-1", "Q91VA0-1", "Q80W40-1", "Q9CZW4-1", "P30624-1", "P39518-1" ], "evidence": [ { "id": "33623", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33623" } ] }, { "id": "33647", "name": "", "equation": "(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63151-1", "O95573-1", "Q9CZW4-1", "P30624-1", "P39518-1", "P47912-1", "P39002-1" ], "evidence": [ { "id": "33647", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33647" } ] }, { "id": "33651", "name": "", "equation": "(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A1L1K7-1", "Q63151-1", "Q5FVE4-1", "Q5K4L6-1", "O95573-1", "Q2XU92-1", "Q9CZW4-1", "O88561-1", "P30624-1", "P39002-1", "P39518-1" ], "evidence": [ { "id": "33651", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33651" } ] }, { "id": "36139", "name": "", "equation": "(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q924N5-1", "P97524-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q96GR2-1", "Q9ULC5-1", "O14975-1", "Q6P1M0-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q99PU5-1", "Q9CZW4-1", "Q9QUJ7-1", "O35488-1", "Q91VE0-1", "Q9VVT8-1" ], "evidence": [ { "id": "36139", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36139" } ] }, { "id": "38883", "name": "", "equation": "a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63151-1", "O95573-1", "Q9CZW4-1" ], "evidence": [ { "id": "38883", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38883" } ] }, { "id": "44932", "name": "", "equation": "(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + ATP + CoA = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97524-1", "Q63151-1", "O14975-1", "O95573-1", "O35488-1", "Q9CZW4-1" ], "evidence": [ { "id": "44932", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44932" } ] }, { "id": "44936", "name": "", "equation": "(9Z,12Z,15Z)-octadecatrienoate + ATP + CoA = (9Z,12Z,15Z)-octadecatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97524-1", "Q63151-1", "O14975-1", "O95573-1", "O35488-1", "Q9CZW4-1" ], "evidence": [ { "id": "44936", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44936" } ] }, { "id": "46208", "name": "", "equation": "ATP + CoA + eicosanoate = AMP + diphosphate + eicosanoyl-CoA", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ES38-1", "Q63151-1", "Q9Y2P5-1", "O95573-1", "Q4LDG0-1", "Q9CZW4-1" ], "evidence": [ { "id": "46208", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46208" } ] }, { "id": "48340", "name": "", "equation": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70490-1", "Q7TN78-1", "Q499N5-1", "Q6AYT9-1", "Q6SKG1-1", "Q63151-1", "Q6NUN0-1", "Q53FZ2-1", "Q6P461-1", "P0C7M7-1", "Q08AH1-1", "Q08AH3-1", "Q96CM8-1", "Q68CK6-1", "O95573-1", "Q91VA0-1", "Q8VCW8-1", "Q8BGA8-1", "Q8K0L3-1", "Q80W40-1", "Q3UNX5-1", "Q9CZW4-1", "Q551W4-1", "Q8SSN6-1", "Q9VMR6-1" ], "evidence": [ { "id": "48340", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48340" } ] }, { "id": "52012", "name": "", "equation": "11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "O95573-1", "O60488-1", "Q9ULC5-1", "Q8JZR0-1", "Q9CZW4-1", "Q9QUJ7-1" ], "evidence": [ { "id": "52012", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52012" } ] }, { "id": "52016", "name": "", "equation": "14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1" ], "evidence": [ { "id": "52016", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52016" } ] }, { "id": "52108", "name": "", "equation": "5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1", "Q9VVT8-1" ], "evidence": [ { "id": "52108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52108" } ] }, { "id": "52112", "name": "", "equation": "12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1", "Q9VVT8-1" ], "evidence": [ { "id": "52112", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52112" } ] }, { "id": "52116", "name": "", "equation": "15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O35547-1", "O88813-1", "Q63151-1", "P18163-1", "P33124-1", "Q9UKU0-4", "O95573-1", "P33121-1", "O60488-1", "Q9ULC5-1", "Q91WC3-1", "Q8JZR0-1", "P41216-1", "Q9CZW4-1", "Q9QUJ7-1", "Q9VVT8-1" ], "evidence": [ { "id": "52116", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52116" } ] }, { "id": "67848", "name": "", "equation": "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q63151-1", "O95573-1", "Q9CZW4-1" ], "evidence": [ { "id": "67848", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/67848" } ] }, { "id": "R-HSA-201035", "name": "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA", "equation": "", "summary": "Membrane-associated acyl-CoA synthetase long-chain family members 1,3,5 and 6 (ACSL1,3,5,6) catalyse the conjugation of palmitate (PALM) with CoA to form palmitoyl-CoA (PALM-CoA). Human ACSL1 has not been characterized in detail, but available data suggest that it is associated specifically with the membrane of the endoplasmic reticulum and that it can act on oleic acid as well as on palmitic acid (Malhotra et al. 1999, Fujimoto et al. 2007, Gassler et al. 2007).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-3632881" ], "output_participant_list": [], "enzyme_list": [ "O95573-1", "Q9UKU0-4", "P33121-1", "Q9ULC5-1" ], "evidence": [ { "id": "R-HSA-201035", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201035" } ] }, { "id": "R-HSA-434382", "name": "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell", "equation": "", "summary": "ACSL3 and ACSL4 found on the mitochondria of pancreatic beta cells ligate coenzyme A (Co-A) to fatty acids such as palmitate (Ansari et al. 2017) prior to transport into mitochondria by the carnitine system and beta oxidation in the mitochondrial matrix yielding ATP.", "cellular_location": "mitochondrial outer membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60488-1", "O95573-1" ], "evidence": [ { "id": "R-HSA-434382", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-434382" } ] }, { "id": "R-HSA-548843", "name": "ACSL3,4 ligate CoA to AA to form AA-CoA", "equation": "", "summary": "Acyl-CoA synthetase long-chain family member 4 (ACSL4) associated with the endoplasmic reticulum membrane catalyses the conjugation of arachidonate (AA) with CoA to form arachidonyl-CoA (AA-CoA) (Longo et al. 2003, Meloni et al. 2003). By similarity, ACSL3 can also preferentially conjugate CoA on to AA (Yao & Ye 2008). These enzymes are involved in the activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60488-1", "O95573-1" ], "evidence": [ { "id": "R-HSA-548843", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-548843" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-3632881", "participant_name": "PALM [cytosol]", "crossref": [ { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" }, { "id": "C00249", "database": "COMPOUND", "url": "" }, { "id": "15756", "database": "ChEBI", "url": "" }, { "id": "HMDB0000220", "database": "HMDB Metabolite", "url": "" }, { "id": "000006072466", "database": "ZINC", "url": "" }, { "id": "1055", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "8145136", "database": "PubChem Substance", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4KFE4", "gene_name": "Acsl", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A0A0B4KFE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KFE4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A0A0B4KFE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KFE4" } ] } ] }, { "uniprot_ac": "A1L1K7", "gene_name": "Acsbg2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "A1L1K7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1K7" } ] } ] }, { "uniprot_ac": "E9Q9W4", "gene_name": "Slc27a6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "E9Q9W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9W4" } ] } ] }, { "uniprot_ac": "O14975", "gene_name": "SLC27A2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O14975", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14975" } ] } ] }, { "uniprot_ac": "O35488", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O35488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35488" } ] } ] }, { "uniprot_ac": "O35547", "gene_name": "Acsl4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O35547", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35547" } ] } ] }, { "uniprot_ac": "O60488", "gene_name": "ACSL4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O60488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60488" } ] } ] }, { "uniprot_ac": "O70490", "gene_name": "Acsm2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70490" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70490" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "O70490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70490" } ] } ] }, { "uniprot_ac": "O88561", "gene_name": "Slc27a3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88561", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88561" } ] } ] }, { "uniprot_ac": "O88813", "gene_name": "Acsl5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "O88813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88813" } ] } ] }, { "uniprot_ac": "O95573", "gene_name": "ACSL3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "O95573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95573" } ] } ] }, { "uniprot_ac": "P0C7M7", "gene_name": "ACSM4", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P0C7M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C7M7" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "P0C7M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C7M7" } ] } ] }, { "uniprot_ac": "P18163", "gene_name": "Acsl1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P18163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18163" } ] } ] }, { "uniprot_ac": "P30624", "gene_name": "FAA1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P30624", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30624" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P30624", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30624" } ] } ] }, { "uniprot_ac": "P33121", "gene_name": "ACSL1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P33121", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33121" } ] } ] }, { "uniprot_ac": "P33124", "gene_name": "Acsl6", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P33124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33124" } ] } ] }, { "uniprot_ac": "P39002", "gene_name": "FAA3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P39002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39002" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P39002", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39002" } ] } ] }, { "uniprot_ac": "P39518", "gene_name": "FAA2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P39518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39518" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P39518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39518" } ] } ] }, { "uniprot_ac": "P41216", "gene_name": "Acsl1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "P41216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41216" } ] } ] }, { "uniprot_ac": "P47912", "gene_name": "FAA4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P47912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47912" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P47912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47912" } ] } ] }, { "uniprot_ac": "P97524", "gene_name": "Slc27a2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.24", "activity": "3,7,11,15-tetramethylhexadecanoate + ATP + CoA = AMP + diphosphate + phytanoyl-CoA.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97524", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97524" } ] } ] }, { "uniprot_ac": "P97849", "gene_name": "Slc27a1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "P97849", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97849" } ] } ] }, { "uniprot_ac": "Q08AH1", "gene_name": "ACSM1", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q08AH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH1" } ] } ] }, { "uniprot_ac": "Q08AH3", "gene_name": "ACSM2A", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q08AH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH3" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q08AH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH3" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q08AH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08AH3" } ] } ] }, { "uniprot_ac": "Q1ZXQ4", "gene_name": "fcsB", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q1ZXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXQ4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q1ZXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXQ4" } ] } ] }, { "uniprot_ac": "Q2XU92", "gene_name": "Acsbg2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q2XU92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2XU92" } ] } ] }, { "uniprot_ac": "Q3UNX5", "gene_name": "Acsm3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q3UNX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UNX5" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q3UNX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UNX5" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q3UNX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UNX5" } ] } ] }, { "uniprot_ac": "Q499N5", "gene_name": "Acsf2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q499N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q499N5" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q499N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q499N5" } ] } ] }, { "uniprot_ac": "Q4LDG0", "gene_name": "Slc27a5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q4LDG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4LDG0" } ] } ] }, { "uniprot_ac": "Q53FZ2", "gene_name": "ACSM3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q53FZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53FZ2" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q53FZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53FZ2" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q53FZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53FZ2" } ] } ] }, { "uniprot_ac": "Q551W4", "gene_name": "", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q551W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q551W4" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q551W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q551W4" } ] } ] }, { "uniprot_ac": "Q55DR6", "gene_name": "fcsA", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q55DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR6" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q55DR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR6" } ] } ] }, { "uniprot_ac": "Q5FVE4", "gene_name": "ACSBG2", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "Q5FVE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVE4" } ] } ] }, { "uniprot_ac": "Q5K4L6", "gene_name": "SLC27A3", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q5K4L6", "database": 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} ] }, { "uniprot_ac": "Q6AYT9", "gene_name": "Acsm5", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6AYT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT9" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q6AYT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT9" } ] } ] }, { "uniprot_ac": "Q6NUN0", "gene_name": "ACSM5", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6NUN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NUN0" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q6NUN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NUN0" } ] } ] }, { "uniprot_ac": "Q6P1M0", "gene_name": "SLC27A4", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P1M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1M0" } ] } ] }, { "uniprot_ac": "Q6P461", "gene_name": "ACSM6", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6P461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P461" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q6P461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P461" } ] } ] }, { "uniprot_ac": "Q6PCB7", "gene_name": "SLC27A1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6PCB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB7" } ] } ] }, { "uniprot_ac": "Q6SKG1", "gene_name": "Acsm3", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6SKG1" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6SKG1" } ] }, { "ec_number": "6.2.1.17", "activity": "ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA.", "evidence": [ { "id": "Q6SKG1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6SKG1" } ] } ] }, { "uniprot_ac": "Q7TN78", "gene_name": "Acsm4", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q7TN78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TN78" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q7TN78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TN78" } ] } ] }, { "uniprot_ac": "Q80W40", "gene_name": "Acsm4", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q80W40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80W40" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q80W40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80W40" } ] } ] }, { "uniprot_ac": "Q8BGA8", "gene_name": "Acsm5", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8BGA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGA8" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q8BGA8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGA8" } ] } ] }, { "uniprot_ac": "Q8JZR0", "gene_name": "Acsl5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8JZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZR0" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8JZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZR0" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q8JZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZR0" } ] } ] }, { "uniprot_ac": "Q8K0L3", "gene_name": "Acsm2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8K0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q8K0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ] }, { "ec_number": "6.2.1.25", "activity": "ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate.", "evidence": [ { "id": "Q8K0L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K0L3" } ] } ] }, { "uniprot_ac": "Q8SSN6", "gene_name": "", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q8SSN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSN6" } ] }, { "ec_number": "6.2.1.2", "activity": "", "evidence": [ { "id": "Q8SSN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8SSN6" } ] } ] }, { "uniprot_ac": "Q8VCW8", "gene_name": "Acsf2", "activity": [ { "ec_number": "6.2.1.2", "activity": "a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { 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"evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] }, { "ec_number": "6.2.1.15", "activity": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] }, { "ec_number": "6.2.1.15", "activity": "", "evidence": [ { "id": "Q91WC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WC3" } ] } ] }, { "uniprot_ac": "Q924N5", "gene_name": "Acsbg1", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q924N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924N5" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q924N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924N5" } ] } ] }, { 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"(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9CZW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZW4" } ] }, { "ec_number": "6.2.1.3", "activity": "", "evidence": [ { "id": "Q9CZW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZW4" } ] } ] }, { "uniprot_ac": "Q9ES38", "gene_name": "Slc27a5", "activity": [ { "ec_number": "6.2.1.3", "activity": "a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9ES38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES38" } ] }, { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "Q9ES38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES38" } ] }, { "ec_number": "6.2.1.7", "activity": "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = 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