{ "uniprot_canonical_ac": "O95528-1", "uniprot_ac": "O95528", "uniprot_id": "GTR10_HUMAN", "mass": { "chemical_mass": 56911.0, "monoisotopic_mass": 56911.0 }, "refseq": { "ac": "NP_110404", "name": "solute carrier family 2, facilitated glucose transporter member 10", "summary": "This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404" }, "gene_names": [ { "name": "SLC2A10", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95528", "id": "O95528" }, { "name": "ATORS; ATS; GLUT10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404", "id": "NP_110404" }, { "name": "GLUT10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95528", "id": "O95528" }, { "name": "SLC2A10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404", "id": "NP_110404" } ], "protein_names": [ { "name": "Solute carrier family 2, facilitated glucose transporter member 10", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95528" }, { "name": "GLUT-10; glucose transporter type 10; solute carrier family 2 (facilitated glucose transporter), member 10; facilitative glucose transporter GLUT10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404", "id": "NP_110404" }, { "name": "GLUT-10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95528" }, { "name": "Glucose transporter type 10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95528" }, { "name": "solute carrier family 2, facilitated glucose transporter member 10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404", "id": "NP_110404" } ], "function": [ { "annotation": "Complex regulatory mechanism of SLC2A10 expression through interaction of multiple transcription factors on basal promotor and prescence of distal repressor sequence suggests fine modulation of GLUT10 levels critical for glucose homeostasis.", "evidence": [ { "database": "RefSeq", "id": "NP_110404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404" }, { "database": "PubMed", "id": "16051383", "url": "https://glygen.org/publication/PubMed/16051383" } ] }, { "annotation": "Data show that GLUT10 regulates adipogenesis via ascorbic acid-dependent DNA demethylation to benefit proper white adipose tissue development and protect mice against high-fat diet (HFD)-induced metabolic dysregulation. These findings suggest that SLC2A10 may be an important HFD-associated susceptibility locus for type 2 diabetes mellitus. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_110404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404" }, { "database": "PubMed", "id": "32453789", "url": "https://glygen.org/publication/PubMed/32453789" } ] }, { "annotation": "Facilitative glucose transporter required for the development of the cardiovascular system.", "evidence": [ { "database": "UniProtKB", "id": "O95528", "url": "https://www.uniprot.org/uniprot/O95528#function" }, { "database": "PubMed", "id": "16550171", "url": "https://glygen.org/publication/PubMed/16550171" }, { "database": "PubMed", "id": "11592815", "url": "https://glygen.org/publication/PubMed/11592815" } ] }, { "annotation": "H22954, a long non-coding RNA, inhibits glucose uptake in leukemia cells in a GLUT10-dependent manner.", "evidence": [ { "database": "RefSeq", "id": "NP_110404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404" }, { "database": "PubMed", "id": "35413230", "url": "https://glygen.org/publication/PubMed/35413230" } ] }, { "annotation": "This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_110404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404" } ] } ], "disease": [ { "disease_id": "DOID:0050645", "recommended_name": { "id": "DOID:0050645", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050645", "name": "arterial tortuosity syndrome", "description": "A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta." }, "synonyms": [ { "id": "MONDO:0008818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008818", "name": "arterial tortuosity syndrome", "description": "Arterial tortuosity syndrome (ATS) is a rare connective tissue disorder characterized by tortuosity and elongation of the large and medium-sized arteries and a propensity towards aneurysm formation, vascular 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passed 1 out of 1 filters: n-glyco-sequon-loss (NAT->KAT).", "chr_id": "20", "chr_pos": "46726038", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N334", "disease": [ { "disease_id": "DOID:0050645", "recommended_name": { "id": "DOID:0050645", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050645", "name": "arterial tortuosity syndrome", "description": "A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta." }, "synonyms": [ { "id": "MONDO:0008818", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008818", "name": "arterial tortuosity syndrome", "description": "Arterial tortuosity syndrome (ATS) is a rare connective tissue disorder characterized by tortuosity and elongation of the large and medium-sized arteries and a propensity towards aneurysm formation, vascular dissection, and stenosis of the pulmonary arteries." }, { 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"description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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"id": "R-HSA-5619068", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5619068", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_110404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110404", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "60376", "url": "https://www.rhea-db.org/rhea/60376", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A087WUH5", "url": "https://www.uniprot.org/uniprot/A0A087WUH5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WUH5-1", "url": "https://www.uniprot.org/uniprot/A0A087WUH5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95528", "url": "https://www.uniprot.org/uniprot/O95528", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95528-1", "url": "https://www.uniprot.org/uniprot/O95528-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKKTKPHPRSGDPSAPPRLALSSALPGPPLPARGHALLRWTALLCLMVFVSAFSFGFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLTAVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS", "length": 541, "header": "sp|O95528-1|GTR10_HUMAN Isoform 1 of Solute carrier family 2, facilitated glucose transporter member 10 OS=Homo sapiens OX=9606 GN=SLC2A10 PE=1 SV=2 CANONICAL=O95528-1" }, "isoforms": [ { "isoform_ac": "A0A087WUH5-1", "url": "", "sequence": { "sequence": "MAPTRAQALSRAP", "length": 13, "header": "tr|A0A087WUH5-1|GTR10_HUMAN Computationally mapped isoform of Solute carrier family 2, facilitated glucose transporter member 10 OS=Homo sapiens OX=9606 GN=SLC2A10 PE=1 SV=1 CANONICAL=O95528-1" }, "locus": { "chromosome": "20", "start_pos": 46710017, "end_pos": 46709737, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000486000.2", "url": "https://www.ensembl.org/id/ENST00000486000.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000478679.1", "url": "https://www.ensembl.org/id/ENSP00000478679.1" } ] } }, { "isoform_ac": "O95528-1", "url": "", "sequence": { "sequence": 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"id": "ENSP00000352216.2", "url": "https://www.ensembl.org/id/ENSP00000352216.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 334, "start_aa": "Asn", "end_pos": 334, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn334", "evidence": [ { "id": "O95528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95528#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Doege H, Schurmann A, Bahrenberg G, Brauers A, Joost HG", "evidence": [ { "database": "Reactome", "id": "R-HSA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-189200" } ], "reference": [ { "type": "PubMed", "id": "10821868", "url": "https://glygen.org/publication/PubMed/10821868" } ] }, { "title": "Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).", "journal": "Genomics", "date": "2000", "authors": "Phay JE, Hussain HB, Moley JF", "evidence": [ { "database": "Reactome", "id": "R-HSA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-189200" } ], "reference": [ { "type": "PubMed", "id": "10860667", "url": "https://glygen.org/publication/PubMed/10860667" } ] }, { "title": "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes.", "journal": "The Biochemical journal", "date": "2000", "authors": "Doege H, Bocianski A, Joost HG, Schurmann A", "evidence": [ { "database": "Reactome", "id": "R-HSA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-189200" } ], "reference": [ { "type": "PubMed", "id": "10970791", "url": "https://glygen.org/publication/PubMed/10970791" } ] }, { "title": "A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato-renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity.", "journal": "Human genetics", "date": "1999", "authors": "Burwinkel B, Sanjad SA, Al-Sabban E, Al-Abbad A, Kilimann MW", "evidence": [ { "database": "Reactome", "id": "R-HSA-189200", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-189200" } ], "reference": [ { "type": "PubMed", "id": "10987651", "url": "https://glygen.org/publication/PubMed/10987651" } ] }, { "title": "Renal Na(+)-glucose cotransporters.", "journal": "American journal of physiology. 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