{ "uniprot_canonical_ac": "O95407-1", "uniprot_ac": "O95407", "uniprot_id": "TNF6B_HUMAN", "mass": { "chemical_mass": 32680.0, "monoisotopic_mass": 32680.0 }, "refseq": { "ac": "NP_003814", "name": "tumor necrosis factor receptor superfamily member 6B precursor", "summary": "This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, "gene_names": [ { "name": "TNFRSF6B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95407", "id": "O95407" }, { "name": "DCR3; DJ583P15.1.1; M68; M68E; TR6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814", "id": "NP_003814" }, { "name": "DCR3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95407", "id": "O95407" }, { "name": "PRO212", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95407", "id": "O95407" }, { "name": "TNFRSF6B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814", "id": "NP_003814" }, { "name": "TR6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95407", "id": "O95407" } ], "protein_names": [ { "name": "Tumor necrosis factor receptor superfamily member 6B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95407" }, { "name": "DcR3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95407" }, { "name": "Decoy receptor 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95407" }, { "name": "Decoy receptor for Fas ligand", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95407" }, { "name": "M68", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95407" }, { "name": "decoy receptor for Fas ligand; tumor necrosis factor receptor superfamily, member 6b, decoy; tumor necrosis factor receptor superfamily member 6b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814", "id": "NP_003814" }, { "name": "tumor necrosis factor receptor superfamily member 6B precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814", "id": "NP_003814" } ], "function": [ { "annotation": "As a soluble receptor.Fc fusion protein, DcR3 modulates dendritic cell differentiation and maturation from CD14+ monocytes by up-regulation of CD86/B7.2 and down-regulation of CD40, CD54/ICAM-1, CD80/B7.1, CD1a, and HLA-DR.", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, { "database": "PubMed", "id": "11994433", "url": "https://glygen.org/publication/PubMed/11994433" } ] }, { "annotation": "DcR3 was highly expressed in patients with acute-on-chronic liver failure and correlated with several clinical indices. Dynamic change of DcR3 might predict the prognosis of acute-on-chronic liver failure . Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, { "database": "PubMed", "id": "31317042", "url": "https://glygen.org/publication/PubMed/31317042" } ] }, { "annotation": "Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation.", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, { "database": "PubMed", "id": "35478210", "url": "https://glygen.org/publication/PubMed/35478210" } ] }, { "annotation": "Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "O95407", "url": "https://www.uniprot.org/uniprot/O95407#function" }, { "database": "PubMed", "id": "21300286", "url": "https://glygen.org/publication/PubMed/21300286" } ] }, { "annotation": "Significantly higher levels of TL1A and its decoy receptor DcR3 in RA patients than in controls; TL1A is significantly related to the disease activity and enhances IL-17 production", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, { "database": "PubMed", "id": "31332995", "url": "https://glygen.org/publication/PubMed/31332995" } ] }, { "annotation": "TNFSF/TNFRSF cytokine gene expression in sickle cell anemia: Up-regulated TNF-like cytokine 1A (TL1A) and its decoy receptor (DcR3) in peripheral blood mononuclear cells and plasma.", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, { "database": "PubMed", "id": "31255916", "url": "https://glygen.org/publication/PubMed/31255916" } ] }, { "annotation": "This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" } ] }, { "annotation": "[miR-148b inhibits M2 polarization of LPS-stimulated macrophages by targeting DcR3].", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" }, { "database": "PubMed", "id": "37574317", "url": "https://glygen.org/publication/PubMed/37574317" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs762956376", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762956376" }, { "id": "rs762956376", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762956376" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 173, "end_pos": 173, "sequence_org": "N", "sequence_mut": "H", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->HCT).", "chr_id": "20", "chr_pos": "63697420", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N173", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1298988086", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1298988086" }, { "id": "rs1298988086", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1298988086#frequency_tab" }, { "id": "rs1298988086", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1298988086" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 173, "end_pos": 173, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->KCT).", "chr_id": "20", "chr_pos": "63697422", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N173", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs766896651", "database": "dbSNP", "url": 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"https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs752074623" }, { "id": "rs752074623", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs752074623" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 175, "end_pos": 175, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->NCA).", "chr_id": "20", "chr_pos": "63697426", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T175", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs755305758", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755305758" }, { "id": "rs755305758", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755305758" }, { "id": "rs755305758", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755305758#frequency_tab" }, { "id": "rs755305758", "database": 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mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HDT->NDT).", "chr_id": "20", "chr_pos": "63697468", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "H189", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1049074867", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1049074867" }, { "id": "rs1049074867", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1049074867" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 203, "end_pos": 203, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "20", "chr_pos": "63697511", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T203", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs775941814", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs775941814" }, { "id": "rs775941814", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs775941814" }, { "id": "rs775941814", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs775941814" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 223, "end_pos": 223, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DIS->NIS).", "chr_id": "20", "chr_pos": "63698327", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D223", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "86.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "46.86", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "75.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "36.69", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "60.1", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "79.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "33.95", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "61.44", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "74.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509" } ] } ], "expression_disease": [], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95407", "url": "https://www.uniprot.org/uniprot/O95407" } ], "common_name": "Human" } ], "gene": [ { "name": "TNFRSF6B", "url": "https://www.uniprot.org/uniprot/O95407", "locus": { "chromosome": "20", "start_pos": 63698684, "end_pos": 63696652, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000243509", "url": "https://www.ensembl.org/id/ENSG00000243509" } ] } } ], "crossref": [ { "id": "ENSG00000243509", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243509", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd10575", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10575", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "TNFRSF6B", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TNFRSF6B", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "8771", "url": "https://www.ncbi.nlm.nih.gov/gene/8771", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "11921", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11921", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O95407", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95407*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001368", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001368", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034023", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034023", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:8771", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8771", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603361", "url": "http://www.omim.org/entry/603361", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O95407", "url": "https://www.nextprot.org/entry/NX_O95407", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "PCQPHQD", "url": "https://omabrowser.org/oma/group/PCQPHQD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5348767at2759", "url": "http://www.orthodb.org/?query=5348767at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23097", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23097", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23097:SF116", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23097:SF116", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3K51", "url": "https://www.rcsb.org/structure/3K51", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3MHD", "url": "https://www.rcsb.org/structure/3MHD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3MI8", "url": "https://www.rcsb.org/structure/3MI8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4J6G", "url": "https://www.rcsb.org/structure/4J6G", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4KGG", "url": "https://www.rcsb.org/structure/4KGG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4KGQ", "url": "https://www.rcsb.org/structure/4KGQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4MSV", "url": "https://www.rcsb.org/structure/4MSV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5L36", "url": "https://www.rcsb.org/structure/5L36", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00020", "url": "http://pfam.xfam.org/family/PF00020", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95407", "url": "https://pharos.nih.gov/targets/O95407", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:000050900", "url": "https://proconsortium.org/app/entry/PR:000050900", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_O95407", "url": "http://purl.obolibrary.org/obo/PR_O95407", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O95407", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "O95407", "url": "https://www.uniprot.org/uniprot/O95407", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95407-1", "url": "https://www.uniprot.org/uniprot/O95407-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH", "length": 300, "header": "sp|O95407-1|TNF6B_HUMAN Isoform 1 of Tumor necrosis factor receptor superfamily member 6B OS=Homo sapiens OX=9606 GN=TNFRSF6B PE=1 SV=1 CANONICAL=O95407-1" }, "isoforms": [ { "isoform_ac": "O95407-1", "url": "", "sequence": { "sequence": "MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH", "length": 300, "header": "sp|O95407-1|TNF6B_HUMAN Isoform 1 of Tumor necrosis factor receptor superfamily member 6B OS=Homo sapiens OX=9606 GN=TNFRSF6B PE=1 SV=1 CANONICAL=O95407-1" }, "locus": { "chromosome": "20", "start_pos": 63698560, "end_pos": 63696768, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369996.3", "url": "https://www.ensembl.org/id/ENST00000369996.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000359013.1", "url": "https://www.ensembl.org/id/ENSP00000359013.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 173, "start_aa": "Asn", "end_pos": 173, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn173", "evidence": [ { "id": "O95407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95407#ptm_processing" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 203, "start_aa": "Thr", "end_pos": 203, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr203", "evidence": [ { "id": "O95407", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR.", "journal": "Current biology : CB", "date": "1999", "authors": "Gurney AL, Marsters SA, Huang RM, Pitti RM, Mark DT, Baldwin DT, Gray AM, Dowd AD, Brush AD, Heldens AD, Schow AD, Goddard AD, Wood WI, Baker KP, Godowski PJ, Ashkenazi A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "10074428", "url": "https://glygen.org/publication/PubMed/10074428" } ] }, { "title": "A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Yu K Y, Kwon B, Ni J, Zhai Y, Ebner R, Kwon B S", "evidence": [ { "database": "UniProtKB", "id": "O95407", "url": "https://www.uniprot.org/uniprot/O95407" } ], "reference": [ { "type": "PubMed", "id": "10318773", "url": "https://glygen.org/publication/PubMed/10318773" } ] }, { "title": "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.", "journal": "The Journal of experimental medicine", "date": "1999", "authors": "Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "10359578", "url": "https://glygen.org/publication/PubMed/10359578" } ] }, { "title": "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, Li Y, Galperina O, Giri J, Roschke V, Nardelli B, Carrell J, Sosnovtseva S, Greenfield W, Ruben SM, Olsen HS, Fikes J, Hilbert DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "10398604", "url": "https://glygen.org/publication/PubMed/10398604" } ] }, { "title": "Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells.", "journal": "Human molecular genetics", "date": "1999", "authors": "Ezer S, Bayes M, Elomaa O, Schlessinger D, Kere J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "10484778", "url": "https://glygen.org/publication/PubMed/10484778" } ] }, { "title": "VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth.", "journal": "Oncogene", "date": "1999", "authors": "Haridas V, Shrivastava A, Su J, Yu GL, Ni J, Liu D, Chen SF, Ni Y, Ruben SM, Gentz R, Aggarwal BB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "10597252", "url": "https://glygen.org/publication/PubMed/10597252" } ] }, { "title": "Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis.", "journal": "Nature genetics", "date": "2000", "authors": "Hughes AE, Ralston SH, Marken J, Bell C, MacPherson H, Wallace RG, van Hul W, Whyte MP, Nakatsuka K, Hovy L, Anderson DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "10615125", "url": "https://glygen.org/publication/PubMed/10615125" } ] }, { "title": "Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Bai C, Connolly B, Metzker M L, Hilliard C A, Liu X, Sandig V, Soderman A, Galloway S M, Liu Q, Austin C P, Caskey C T", "evidence": [ { "database": "UniProtKB", "id": "O95407", "url": "https://www.uniprot.org/uniprot/O95407" } ], "reference": [ { "type": "PubMed", "id": "10655513", "url": "https://glygen.org/publication/PubMed/10655513" } ] }, { "title": "Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase.", "journal": "EMBO reports", "date": "2001", "authors": "Lopez-Fraga M, Fernandez R, Albar JP, Hahne M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "11571266", "url": "https://glygen.org/publication/PubMed/11571266" } ] }, { "title": "Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.", "journal": "Current biology : CB", "date": "2002", "authors": "Yan M, Zhang Z, Brady JR, Schilbach S, Fairbrother WJ, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "11882293", "url": "https://glygen.org/publication/PubMed/11882293" } ] }, { "title": "TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator.", "journal": "Immunity", "date": "2002", "authors": "Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "11911831", "url": "https://glygen.org/publication/PubMed/11911831" } ] }, { "title": "Modulation of dendritic cell differentiation and maturation by decoy receptor 3.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2002", "authors": "Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL", "evidence": [ { "database": "RefSeq", "id": "NP_003814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003814" } ], "reference": [ { "type": "PubMed", "id": "11994433", "url": "https://glygen.org/publication/PubMed/11994433" } ] }, { "title": "A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype.", "journal": "Human molecular genetics", "date": "2002", "authors": "Cundy T, Hegde M, Naot D, Chong B, King A, Wallace R, Mulley J, Love DR, Seidel J, Fawkner M, Banovic T, Callon KE, Grey AB, Reid IR, Middleton-Hardie CA, Cornish J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "12189164", "url": "https://glygen.org/publication/PubMed/12189164" } ] }, { "title": "Signalling pathways of the TNF superfamily: a double-edged sword.", "journal": "Nature reviews. Immunology", "date": "2003", "authors": "Aggarwal BB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "12949498", "url": "https://glygen.org/publication/PubMed/12949498" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "O95407", "url": "https://www.uniprot.org/uniprot/O95407" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.", "journal": "Structure (London, England : 1993)", "date": "2003", "authors": "Hymowitz SG, Compaan DM, Yan M, Wallweber HJ, Dixit VM, Starovasnik MA, de Vos AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "14656435", "url": "https://glygen.org/publication/PubMed/14656435" } ] }, { "title": "Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2004", "authors": "Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier LL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "15356117", "url": "https://glygen.org/publication/PubMed/15356117" } ] }, { "title": "T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2004", "authors": "Kashiwakura J, Yokoi H, Saito H, Okayama Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "15470070", "url": "https://glygen.org/publication/PubMed/15470070" } ] }, { "title": "Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "So T, Song J, Sugie K, Altman A, Croft M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "16501042", "url": "https://glygen.org/publication/PubMed/16501042" } ] }, { "title": "The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1991", "authors": "Camerini D, Walz G, Loenen WA, Borst J, Seed B", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "1655907", "url": "https://glygen.org/publication/PubMed/1655907" } ] }, { "title": "Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.", "journal": "Nature genetics", "date": "2007", "authors": "Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], "reference": [ { "type": "PubMed", "id": "17632511", "url": "https://glygen.org/publication/PubMed/17632511" } ] }, { "title": "The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.", "journal": "Immunity", "date": "2008", "authors": "Meylan F, Davidson TS, Kahle E, Kinder M, Acharya K, Jankovic D, Bundoc V, Hodges M, Shevach EM, Keane-Myers A, Wang EC, Siegel RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5669034", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5669034" } ], 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