{ "uniprot_canonical_ac": "O95372-1", "uniprot_ac": "O95372", "uniprot_id": "LYPA2_HUMAN", "mass": { "chemical_mass": 24737.0, "monoisotopic_mass": 24737.0 }, "refseq": { "ac": "NP_009191", "name": "acyl-protein thioesterase 2", "summary": "Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" }, "gene_names": [ { "name": "LYPLA2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95372", "id": "O95372" }, { "name": "APT-2; APT2; DJ886K2.4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191", "id": "NP_009191" }, { "name": "APT2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95372", "id": "O95372" }, { "name": "LYPLA2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191", "id": "NP_009191" } ], "protein_names": [ { "name": "Acyl-protein thioesterase 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95372" }, { "name": "3.1.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "3.1.2.22", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "APT-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "LPL-II; lysoPLA II; testicular tissue protein Li 3; lysophospholipase II; palmitoyl-protein hydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191", "id": "NP_009191" }, { "name": "LPL-II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "LysoPLA II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "Lysophospholipase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "Palmitoyl-protein hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95372" }, { "name": "acyl-protein thioesterase 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191", "id": "NP_009191" } ], "function": [ { "annotation": "Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951).", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372#function" }, { "database": "PubMed", "id": "21152083", "url": "https://glygen.org/publication/PubMed/21152083" }, { "database": "PubMed", "id": "28826475", "url": "https://glygen.org/publication/PubMed/28826475" }, { "database": "PubMed", "id": "25301951", "url": "https://glygen.org/publication/PubMed/25301951" } ] }, { "annotation": "Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" }, { "database": "PubMed", "id": "23396970", "url": "https://glygen.org/publication/PubMed/23396970" } ] }, { "annotation": "Here, we describe the conserved functions of APT1 and APT2 across organisms and discuss the possibility that these enzymes are members of a larger family of depalmitoylation enzymes. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" }, { "database": "PubMed", "id": "25849916", "url": "https://glygen.org/publication/PubMed/25849916" } ] }, { "annotation": "LYPLA1 and LYPLA2 are each able to account for the loss of the other to maintain lipid homeostasis in cells Erratum:[J Lipid Res. 2019 Jul;60(7):1345. PMID: 31262966]", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" }, { "database": "PubMed", "id": "30482805", "url": "https://glygen.org/publication/PubMed/30482805" } ] }, { "annotation": "Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" } ] }, { "annotation": "Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" }, { "database": "PubMed", "id": "33707782", "url": "https://glygen.org/publication/PubMed/33707782" } ] }, { "annotation": "Results demonstrate that APT-2 is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP-43 subcellular distribution. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" }, { "database": "PubMed", "id": "21152083", "url": "https://glygen.org/publication/PubMed/21152083" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 122, "end_pos": 122, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes ability to mediate depalmitoylation of ZDHHC6.", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" }, { "database": "PubMed", "id": "28826475", "url": "https://glygen.org/publication/PubMed/28826475" } ] }, { "start_pos": 2, "end_pos": 2, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolishes palmitoylation.", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" }, { "database": "PubMed", "id": "28826475", "url": "https://glygen.org/publication/PubMed/28826475" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "93.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "82.08", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "91.42", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "90.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "91.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "91.34", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "92.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "85.84", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "90.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "94.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.78", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000011009", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000011009" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O95372", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95372" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"Protein" ] }, { "id": "Q5QPQ3", "url": "https://www.uniprot.org/uniprot/Q5QPQ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QPQ3-1", "url": "https://www.uniprot.org/uniprot/Q5QPQ3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV", "length": 231, "header": "sp|O95372-1|LYPA2_HUMAN Isoform 1 of Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "isoforms": [ { "isoform_ac": "O95372-1", "url": "", "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV", "length": 231, "header": "sp|O95372-1|LYPA2_HUMAN Isoform 1 of Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23794729, "end_pos": 23792683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374514.8", "url": "https://www.ensembl.org/id/ENST00000374514.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000363638.3", "url": "https://www.ensembl.org/id/ENSP00000363638.3" } ] } }, { "isoform_ac": "Q5QPN5-1", "url": "", "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEA", "length": 90, "header": "tr|Q5QPN5-1|LYPA2_HUMAN Computationally mapped isoform of Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=8 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23793905, "end_pos": 23792683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000421070.1", "url": "https://www.ensembl.org/id/ENST00000421070.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000388003.1", "url": "https://www.ensembl.org/id/ENSP00000388003.1" } ] } }, { "isoform_ac": "Q5QPN9-1", "url": "", "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENRRGPVPLHGPHLPPPSGWHRGVELLAASAPGLPPGECPH", "length": 137, "header": "tr|Q5QPN9-1|LYPA2_HUMAN Computationally mapped isoform of Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23794339, "end_pos": 23792683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374505.6", "url": "https://www.ensembl.org/id/ENST00000374505.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000363629.2", "url": "https://www.ensembl.org/id/ENSP00000363629.2" } ] } }, { "isoform_ac": "Q5QPQ0-1", "url": "", "sequence": { "sequence": "MKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV", "length": 164, "header": "tr|Q5QPQ0-1|Q5QPQ0_HUMAN Computationally mapped isoform of palmitoyl-protein hydrolase OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23794729, "end_pos": 23793730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374501.1", "url": "https://www.ensembl.org/id/ENST00000374501.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000363625.1", "url": "https://www.ensembl.org/id/ENSP00000363625.1" } ] } }, { "isoform_ac": "Q5QPQ1-1", "url": "", "sequence": { "sequence": "MLPPCLELSGKRPRHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGA", "length": 162, "header": "tr|Q5QPQ1-1|Q5QPQ1_HUMAN Computationally mapped isoform of palmitoyl-protein hydrolase OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23794510, "end_pos": 23792720, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420982.5", "url": "https://www.ensembl.org/id/ENST00000420982.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000409004.1", "url": "https://www.ensembl.org/id/ENSP00000409004.1" } ] } }, { "isoform_ac": "Q5QPQ2-1", "url": "", "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQGPVQDIPGCHAQLLSSGDGSCEGIS", "length": 182, "header": "tr|Q5QPQ2-1|Q5QPQ2_HUMAN Computationally mapped isoform of palmitoyl-protein hydrolase OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23794707, "end_pos": 23792683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374503.7", "url": "https://www.ensembl.org/id/ENST00000374503.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000363627.3", "url": "https://www.ensembl.org/id/ENSP00000363627.3" } ] } }, { "isoform_ac": "Q5QPQ3-1", "url": "", "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQVNVPTDPPALCVCILVAWGLLQH", "length": 180, "header": "tr|Q5QPQ3-1|Q5QPQ3_HUMAN Computationally mapped isoform of palmitoyl-protein hydrolase OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1 CANONICAL=O95372-1" }, "locus": { "chromosome": "1", "start_pos": 23794394, "end_pos": 23792683, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374502.7", "url": "https://www.ensembl.org/id/ENST00000374502.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000363626.3", "url": "https://www.ensembl.org/id/ENSP00000363626.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O95372", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95372" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "phosphorylation": [ { "start_pos": 82, "end_pos": 82, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "site_lbl": "Ser82" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.", "journal": "Molecular biology of the cell", "date": "2004", "authors": "Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D", "evidence": [ { "database": "Reactome", "id": "R-HSA-373760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373760" } ], "reference": [ { "type": "PubMed", "id": "14978216", "url": "https://glygen.org/publication/PubMed/14978216" } ] }, { "title": "RanBPM is an L1-interacting protein that regulates L1-mediated mitogen-activated protein kinase activation.", "journal": "Journal of neurochemistry", "date": "2005", "authors": "Cheng L, Lemmon S, Lemmon V", "evidence": [ { "database": "Reactome", "id": "R-HSA-373760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373760" } ], "reference": [ { "type": "PubMed", "id": "16000162", "url": "https://glygen.org/publication/PubMed/16000162" } ] }, { "title": "Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.", "journal": "PloS one", "date": "2010", "authors": "Tomatis VM, Trenchi A, Gomez GA, Daniotti JL", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" }, { "database": "Reactome", "id": "R-HSA-373760", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373760" }, { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" } ], "reference": [ { "type": "PubMed", "id": "21152083", "url": "https://glygen.org/publication/PubMed/21152083" } ] }, { "title": "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.", "journal": "Mol. Cell. Proteomics", "date": "2012", "authors": "Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C", "evidence": [ { "database": "UniProtKB", "id": "Q5QPN9", "url": "https://www.uniprot.org/uniprot/Q5QPN9" } ], "reference": [ { "type": "PubMed", "id": "22223895", "url": "https://glygen.org/publication/PubMed/22223895" } ] }, { "title": "Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Kong E, Peng S, Chandra G, Sarkar C, Zhang Z, Bagh MB, Mukherjee AB", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" } ], "reference": [ { "type": "PubMed", "id": "23396970", "url": "https://glygen.org/publication/PubMed/23396970" } ] }, { "title": "Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Manna JD, Wepy JA, Hsu KL, Chang JW, Cravatt BF, Marnett LJ", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "reference": [ { "type": "PubMed", "id": "25301951", "url": "https://glygen.org/publication/PubMed/25301951" } ] }, { "title": "Enzymatic protein depalmitoylation by acyl protein thioesterases.", "journal": "Biochemical Society transactions", "date": "2015", "authors": "Lin DT, Conibear E", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" } ], "reference": [ { "type": "PubMed", "id": "25849916", "url": "https://glygen.org/publication/PubMed/25849916" } ] }, { "title": "Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.", "journal": "eLife", "date": "2017", "authors": "Abrami L, Dallavilla T, Sandoz PA, Demir M, Kunz B, Savoglidis G, Hatzimanikatis V, van der Goot FG", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "reference": [ { "type": "PubMed", "id": "28826475", "url": "https://glygen.org/publication/PubMed/28826475" } ] }, { "title": "Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.", "journal": "Journal of lipid research", "date": "2019", "authors": "Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" } ], "reference": [ { "type": "PubMed", "id": "30482805", "url": "https://glygen.org/publication/PubMed/30482805" } ] }, { "title": "Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.", "journal": "Nature chemical biology", "date": "2021", "authors": "Abrami L, Audagnotto M, Ho S, Marcaida MJ, Mesquita FS, Anwar MU, Sandoz PA, Fonti G, Pojer F, Dal Peraro M, van der Goot FG", "evidence": [ { "database": "RefSeq", "id": "NP_009191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191" } ], "reference": [ { "type": "PubMed", "id": "33707782", "url": "https://glygen.org/publication/PubMed/33707782" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95372", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95372" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "pathway": [ { "id": "hsa:11313", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11313", "resource": "KEGG Pathway" }, { "id": "R-HSA-373760", "name": "L1CAM interactions", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373760", "resource": "Reactome", "description": "L1CAM interactions" } ], "orthologs": [ { "uniprot_canonical_ac": "M9PEW1-1", "protein_name": "palmitoyl-protein hydrolase", "gene_name": "Apt1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MAAPVIVEATVKQTATLIFMHGLGDTGHGWSSALAAIRPPFMKVICPTAPTQPVSLNAGFRMPSWFDLKTLDIGGPEDEPGIQSARDSVHGMIQKEISAGIPANRIVLGGFSQGGALALYSALTYDQPLAGVVALSCWLPLHKQFPGAKVNSDDVPIFQAHGDYDPVVPYKFGQLSASLLKSFMKNVTFKTYSGLSHSSSDDEMDDVKDIISKWTQWDSQNMARKAQCCQLS", "length": 232 }, "evidence": [ { "id": "O95372", "url": "https://omabrowser.org/oma/group/O95372/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q12354-1", "protein_name": "Acyl-protein thioesterase 1", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MNGLRVAAKIQPARQTIIFLHGLGDTGSGWGFLAQYLQQRDPAAFQHTNFVFPNAPELHVTANGGALMPAWFDILEWDPSFSKVDSDGFMNSLNSIEKTVKQEIDKGIKPEQIIIGGFSQGAALALATSVTLPWKIGGIVALSGFCSIPGILKQHKNGINVKTPIFHGHGDMDPVVPIGLGIKAKQFYQDSCEIQNYEFKVYKGMAHSTVPDELEDLASFIKKSLSS", "length": 227 }, "evidence": [ { "id": "O95372", "url": "https://omabrowser.org/oma/group/O95372/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q9QYL8-1", "protein_name": "Acyl-protein thioesterase 2", "gene_name": "Lypla2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MCGNNMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV", "length": 231 }, "evidence": [ { "id": "45927712", "url": "http://www.informatics.jax.org/homology/45927712", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9WTL7-1", "protein_name": "Acyl-protein thioesterase 2", "gene_name": "Lypla2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV", "length": 231 }, "evidence": [ { "id": "45927712", "url": "http://www.informatics.jax.org/homology/45927712", "database": "MGI" }, { "id": "O95372", "url": "https://omabrowser.org/oma/group/O95372/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "carboxylic ester hydrolase activity", "id": "GO:0052689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052689", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "lysophospholipase activity", "id": "GO:0004622", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004622", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "palmitoyl-(protein) hydrolase activity", "id": "GO:0008474", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008474", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "Golgi stack", "id": "GO:0005795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005795", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "acylglycerol catabolic process", "id": "GO:0046464", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046464", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "prostaglandin catabolic process", "id": "GO:1905344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905344", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" }, { "name": "protein depalmitoylation", "id": "GO:0002084", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002084", "evidence": [ { "database": "UniProtKB", "id": "O95372", "url": "https://www.uniprot.org/uniprot/O95372" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "19233", "name": "", "equation": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DFK7-1", "Q5XIJ5-1", "Q6AY17-1", "P45479-1", "Q5I0K5-1", "P70470-1", "Q9QYL8-1", "F1LN46-1", "Q5VST6-1", "Q6PCB6-1", "Q96GS6-1", "P50897-1", "Q9NUJ1-1", "Q5VWZ2-1", "O95372-1", "O75608-1", "Q8TCG5-1", "Q99JW1-1", "Q8VCV1-1", "Q7M759-1", "O88531-1", "Q6PE15-1", "Q9WTL7-1", "Q3UFF7-1", "P97823-1", "Q8BGD5-1", "Q12354-1", "Q54T49-1", "Q55FK4-1", "Q54CM0-1", "Q9W3C7-1" ], "evidence": [ { "id": "19233", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19233" } ] }, { "id": "40435", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "O88202-1", "P97570-1", "O54728-1", "P50393-1", "P70470-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "Q9QYL8-1", "D3ZRC4-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "D4A328-1", "P19835-1", "Q86U10-1", "P0C869-1", "Q6P1J6-1", "P11150-1", "Q7L5L3-2", "O95372-1", "O75608-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q3MJ16-3", "Q8IY17-4", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q64285-1", "A0JNU3-1", "Q50L43-1", "Q9WTL7-1", "P97823-1", "Q8VEB4-1", "Q8K1N1-1", "A2AJ88-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q3TRM4-1", "Q3TTY0-1", "Q99LY2-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q9VMM8-1" ], "evidence": [ { "id": "40435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40435" } ] }, { "id": "40887", "name": "", "equation": "1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + octadecanoate + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88202-1", "Q9QYL8-1", "Q86U10-1", "O95372-1", "A0JNU3-1", "Q9WTL7-1" ], "evidence": [ { "id": "40887", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40887" } ] }, { "id": "44552", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H2O = H(+) + hexadecanoate + sn-glycero-3-phospho-L-serine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYT7-1", "Q9QYL8-1", "Q8N2K0-1", "O95372-1", "Q99LR1-1", "Q9WTL7-1", "Q03674-1" ], "evidence": [ { "id": "44552", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44552" } ] }, { "id": "48296", "name": "", "equation": "H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8R431-1", "Q9QYL8-1", "Q99685-1", "O00748-1", "P23141-1", "O95372-1", "O35678-1", "Q9WTL7-1", "Q8VCC2-1" ], "evidence": [ { "id": "48296", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48296" } ] }, { "id": "49092", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphate + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5BK26-1", "Q9QYL8-1", "O95372-1", "Q8IY17-4", "Q6ZV29-1", "Q9WTL7-1", "A2AJ88-1", "Q3TRM4-1" ], "evidence": [ { "id": "49092", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/49092" } ] }, { "id": "R-HSA-8933328", "name": "LYPLA2 hydrolyses PALM-C3,4-GAP43", "equation": "", "summary": "Neuromodulin (GAP43) is a protein associated with nerve growth. It is a major component of the motile \\growth cones\\ that form the tips of elongating axons (Gauthier-Campbell et al. 2004). An acylation/deacylation cycle is necessary to maintain the steady-state subcellular distribution and biological activity of S-acylated proteins and GAP43 is dually palmitoylated at cysteines 3 and 4 (PALM-C3,4-GAP43). Acyl-protein thioesterase 2 (LYPLA2, APT2) is the protein thioesterase involved in the acylation/deacylation cycle for GAP43 (Tomatis et al. 2010).", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-HSA-8933482" ], "output_participant_list": [ "R-HSA-452888" ], "enzyme_list": [ "O95372-1" ], "evidence": [ { "id": "R-HSA-8933328", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8933328" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-452888", "participant_name": "GAP43 [plasma membrane]", "crossref": [ { "id": "XP_016861617.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000172020", "database": "OpenTargets", "url": "" }, { "id": "ENST00000305124", "database": "Ensembl", "url": "" }, { "id": "P17677", "database": "UniProt", "url": "" }, { "id": "NP_001123536.1", "database": "RefSeq", "url": "" }, { "id": "24557", "database": "Orphanet", "url": "" }, { "id": "NP_002036.1", "database": "RefSeq", "url": "" }, { "id": "P17677", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000172020", "database": "Ensembl", "url": "" }, { "id": "P17677", "database": "GeneCards", "url": "" }, { "id": "ENST00000393780", "database": "Ensembl", "url": "" }, { "id": "ENSG00000172020-GAP43", "database": "HPA", "url": "" }, { "id": "ENSP00000377372", "database": "Ensembl", "url": "" }, { "id": "P17677", "database": "PRO", "url": "" }, { "id": "ENSP00000305010", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-HSA-8933482", "participant_name": "PALM-C3,4-GAP43 [plasma membrane]", "crossref": [ { "id": "P17677", "database": "UniProt", "url": "" }, { "id": "ENSG00000172020-GAP43", "database": "HPA", "url": "" }, { "id": "NP_002036.1", "database": "RefSeq", "url": "" }, { "id": "P17677", "database": "GeneCards", "url": "" }, { "id": "ENSG00000172020", "database": "OpenTargets", "url": "" }, { "id": "ENSP00000305010", "database": "Ensembl", "url": "" }, { "id": "NP_001123536.1", "database": "RefSeq", "url": "" }, { "id": "ENSG00000172020", "database": "Ensembl", "url": "" }, { "id": "ENST00000305124", "database": "Ensembl", "url": "" }, { "id": "ENSP00000377372", "database": "Ensembl", "url": "" }, { "id": "24557", "database": "Orphanet", "url": "" }, { "id": "ENST00000393780", "database": "Ensembl", "url": "" }, { "id": "XP_016861617.1", "database": "RefSeq", "url": "" }, { "id": "P17677", "database": "PRO", "url": "" }, { "id": "P17677", "database": "Pharos - Targets", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0JNU3", "gene_name": "Aspg", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] } ] }, { "uniprot_ac": "A2AJ88", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] } ] }, { "uniprot_ac": "B5DFK7", "gene_name": "Abhd17c", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "B5DFK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFK7" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "B5DFK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFK7" } ] } ] }, { "uniprot_ac": "D3Z9B7", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] } ] }, { "uniprot_ac": "D3ZQH6", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] } ] }, { "uniprot_ac": "D3ZRC4", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] } ] }, { "uniprot_ac": "D4A1I6", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] } ] }, { "uniprot_ac": "D4A328", "gene_name": "LOC120099997", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] } ] }, { "uniprot_ac": "F1LN46", "gene_name": "Cpt1c", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "F1LN46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LN46" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "F1LN46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LN46" } ] }, { "ec_number": "2.3.1.21", "activity": "(R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitine.", "evidence": [ { "id": "F1LN46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LN46" } ] }, { "ec_number": "2.3.1.21", "activity": "", "evidence": [ { "id": "F1LN46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LN46" } ] } ] }, { "uniprot_ac": "F1LPY6", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] } ] }, { "uniprot_ac": "O00748", "gene_name": "CES2", "activity": [ { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "cocaine + H2O = benzoate + ecgonine methyl ester + H(+).", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] }, { "ec_number": "3.1.1.84", "activity": "", "evidence": [ { "id": "O00748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00748" } ] } ] }, { "uniprot_ac": "O35678", "gene_name": "Mgll", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "O35678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35678" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "O35678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35678" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O75608", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] } ] }, { "uniprot_ac": "O88202", "gene_name": "Aspg", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] } ] }, { "uniprot_ac": "O88531", "gene_name": "Ppt1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O88531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88531" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O88531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88531" } ] } ] }, { "uniprot_ac": "O95372", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] } ] }, { "uniprot_ac": "P07867", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] } ] }, { "uniprot_ac": "P07882", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] } ] }, { "uniprot_ac": "P0C869", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] } ] }, { "uniprot_ac": "P0C871", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] } ] }, { "uniprot_ac": "P11150", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] } ] }, { "uniprot_ac": "P19835", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] } ] }, { "uniprot_ac": "P23141", "gene_name": "CES1", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] }, { "ec_number": "3.1.1.56", "activity": "4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+).", "evidence": [ { "id": "P23141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23141" } ] } ] }, { "uniprot_ac": "P27656", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] } ] }, { "uniprot_ac": "P39105", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] } ] }, { "uniprot_ac": "P45479", "gene_name": "Ppt1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P45479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45479" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P45479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45479" } ] } ] }, { "uniprot_ac": "P47712", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] } ] }, { "uniprot_ac": "P47713", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] } ] }, { "uniprot_ac": "P50393", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] } ] }, { "uniprot_ac": "P50897", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P50897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50897" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P50897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50897" } ] } ] }, { "uniprot_ac": "P70470", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "P97823", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] } ] }, { "uniprot_ac": "Q03674", "gene_name": "PLB2", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] } ] }, { "uniprot_ac": "Q12354", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q12354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12354" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q12354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12354" } ] } ] }, { "uniprot_ac": "Q3MJ16", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q3UFF7", "gene_name": "Lyplal1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q3UFF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFF7" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q3UFF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFF7" } ] } ] }, { "uniprot_ac": "Q50L41", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] } ] }, { "uniprot_ac": "Q50L42", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] } ] }, { "uniprot_ac": "Q50L43", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] } ] }, { "uniprot_ac": "Q54CM0", "gene_name": "ppt3", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q54CM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CM0" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q54CM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54CM0" } ] } ] }, { "uniprot_ac": "Q54T49", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q54T49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54T49" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q54T49", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54T49" } ] } ] }, { "uniprot_ac": "Q55FK4", "gene_name": "", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q55FK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FK4" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q55FK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55FK4" } ] } ] }, { "uniprot_ac": "Q5BK26", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] } ] }, { "uniprot_ac": "Q5I0K5", "gene_name": "Abhd10", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] }, { "ec_number": "3.1.1.93", "activity": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate.", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] }, { "ec_number": "3.1.1.93", "activity": "", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5I0K5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5I0K5" } ] } ] }, { "uniprot_ac": "Q5VST6", "gene_name": "ABHD17B", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5VST6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VST6" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5VST6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VST6" } ] } ] }, { "uniprot_ac": "Q5VWZ2", "gene_name": "LYPLAL1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5VWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VWZ2" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5VWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VWZ2" } ] } ] }, { "uniprot_ac": "Q5XIJ5", "gene_name": "Abhd17a", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q5XIJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIJ5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q5XIJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIJ5" } ] } ] }, { "uniprot_ac": "Q64285", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] } ] }, { "uniprot_ac": "Q64GA5", "gene_name": "Pla2g4c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] } ] }, { "uniprot_ac": "Q675A5", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] } ] }, { "uniprot_ac": "Q68DD2", "gene_name": "PLA2G4F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] } ] }, { "uniprot_ac": "Q6AY17", "gene_name": "Abhd17b", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q6AY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY17" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q6AY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY17" } ] } ] }, { "uniprot_ac": "Q6AYT7", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q6AYT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYT7" } ] } ] }, { "uniprot_ac": "Q6P1J6", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q6PCB6", "gene_name": "ABHD17C", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q6PCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB6" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q6PCB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCB6" } ] } ] }, { "uniprot_ac": "Q6PE15", "gene_name": "Abhd10", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q6PE15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PE15" } ] }, { "ec_number": "3.1.1.93", "activity": "H2O + mycophenolic acid O-acyl-beta-D-glucuronide = D-glucuronate + H(+) + mycophenolate.", "evidence": [ { "id": "Q6PE15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PE15" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q6PE15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PE15" } ] } ] }, { "uniprot_ac": "Q6ZV29", "gene_name": "PNPLA7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] } ] }, { "uniprot_ac": "Q7L5L3", "gene_name": "GDPD3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q7L5L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7L5L3" } ] } ] }, { "uniprot_ac": "Q7M759", "gene_name": "Abhd17b", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q7M759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7M759" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q7M759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7M759" } ] } ] }, { "uniprot_ac": "Q86U10", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] } ] }, { "uniprot_ac": "Q8BGD5", "gene_name": "Cpt1c", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q8BGD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGD5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q8BGD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGD5" } ] } ] }, { "uniprot_ac": "Q8IY17", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] } ] }, { "uniprot_ac": "Q8K1N1", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] } ] }, { "uniprot_ac": "Q8N2K0", "gene_name": "ABHD12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q8N2K0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K0" } ] } ] }, { "uniprot_ac": "Q8NCC3", "gene_name": "PLA2G15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] } ] }, { "uniprot_ac": "Q8R431", "gene_name": "Mgll", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q8R431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R431" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q8R431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R431" } ] } ] }, { "uniprot_ac": "Q8TCG5", "gene_name": "CPT1C", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q8TCG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TCG5" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q8TCG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TCG5" } ] } ] }, { "uniprot_ac": "Q8VCC2", "gene_name": "Ces1", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q8VCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCC2" } ] }, { "ec_number": "3.1.1.1", "activity": "a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).", "evidence": [ { "id": "Q8VCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCC2" } ] }, { "ec_number": "3.1.1.1", "activity": "", "evidence": [ { "id": "Q8VCC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCC2" } ] } ] }, { "uniprot_ac": "Q8VCV1", "gene_name": "Abhd17c", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q8VCV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCV1" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q8VCV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCV1" } ] } ] }, { "uniprot_ac": "Q8VEB4", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] } ] }, { "uniprot_ac": "Q96GS6", "gene_name": "ABHD17A", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q96GS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GS6" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q96GS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GS6" } ] } ] }, { "uniprot_ac": "Q99685", "gene_name": "MGLL", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q99685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99685" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q99685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99685" } ] } ] }, { "uniprot_ac": "Q99JW1", "gene_name": "Abhd17a", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q99JW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JW1" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q99JW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JW1" } ] } ] }, { "uniprot_ac": "Q99LR1", "gene_name": "Abhd12", "activity": [ { "ec_number": "3.1.1.23", "activity": "Hydrolyzes glycerol monoesters of long-chain fatty acids.", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] }, { "ec_number": "3.1.1.23", "activity": "", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] }, { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q99LR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LR1" } ] } ] }, { "uniprot_ac": "Q99LY2", "gene_name": "Gdpd3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q99LY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LY2" } ] } ] }, { "uniprot_ac": "Q9NP80", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] } ] }, { "uniprot_ac": "Q9NUJ1", "gene_name": "ABHD10", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q9NUJ1", "database": "UniProtKB", "url": 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