{ "uniprot_canonical_ac": "O95359-4", "uniprot_ac": "O95359", "uniprot_id": "TACC2_HUMAN", "mass": { "chemical_mass": 309427.0, "monoisotopic_mass": 309427.0 }, "refseq": { "ac": "NP_001278807", "name": "transforming acidic coiled-coil-containing protein 2 isoform g", "summary": "Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" }, "gene_names": [ { "name": "TACC2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95359", "id": "O95359" }, { "name": "AZU-1; ECTACC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807", "id": "NP_001278807" }, { "name": "TACC2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807", "id": "NP_001278807" } ], "protein_names": [ { "name": "Transforming acidic coiled-coil-containing protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95359" }, { "name": "AZU-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95359" }, { "name": "Anti-Zuai-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95359" }, { "name": "anti zuai-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807", "id": "NP_001278807" }, { "name": "transforming acidic coiled-coil-containing protein 2 isoform g", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807", "id": "NP_001278807" } ], "function": [ { "annotation": "Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" }, { "database": "PubMed", "id": "31996486", "url": "https://glygen.org/publication/PubMed/31996486" } ] }, { "annotation": "Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter. Erratum:[Sci Rep. 2021 Aug 13;11(1):16835. PMID: 34389798] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" }, { "database": "PubMed", "id": "33931666", "url": "https://glygen.org/publication/PubMed/33931666" } ] }, { "annotation": "Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359#function" }, { "database": "PubMed", "id": "10749935", "url": "https://glygen.org/publication/PubMed/10749935" } ] }, { "annotation": "TACC2 protein is expressed mainly in the nucleus of the endometrial cancer cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" }, { "database": "PubMed", "id": "29074988", "url": "https://glygen.org/publication/PubMed/29074988" } ] }, { "annotation": "These results suggest that TACC2 plays an important role in the cell proliferation of breast carcinoma and therefore immunohistochemical TACC2 status is a candidate of worse prognostic factor in breast cancer cases.", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" }, { "database": "PubMed", "id": "27333920", "url": "https://glygen.org/publication/PubMed/27333920" } ] }, { "annotation": "This finding suggests that TACC2 may be a useful tool as a candidate biomarker to predict the recurrence and prognosis of hepatocellular carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" }, { "database": "PubMed", "id": "29843208", "url": "https://glygen.org/publication/PubMed/29843208" } ] }, { "annotation": "Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O95359", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95359" }, { "id": "rs1418714196", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1418714196" }, { "id": "rs1418714196", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1418714196" }, { "id": "rs1418714196", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1418714196" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1209, "end_pos": 1209, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DFS->NFS).", "chr_id": "10", "chr_pos": "122086125", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D1209", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1290174956", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1290174956" }, { "id": "rs1290174956", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1290174956#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1311, "end_pos": 1311, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SGS->NGS).", "chr_id": "10", "chr_pos": "122086432", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1311", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs2420985", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2420985" }, { "id": "rs2420985", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs2420985" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1356, "end_pos": 1356, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KAS->NAS).", "chr_id": "10", "chr_pos": "122086568", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K1356", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1427545282", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1427545282" }, { "id": "rs1427545282", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1427545282" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 135, "end_pos": 135, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TQS->NQS).", "chr_id": "10", "chr_pos": "122082904", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T135", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs73370132", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs73370132" }, { "id": "rs73370132", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs73370132" }, { "id": "rs73370132", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs73370132" }, { "id": "rs73370132", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs73370132#frequency_tab" }, { "id": "rs73370132", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs73370132" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1393, "end_pos": 1393, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DTS->NTS).", "chr_id": "10", "chr_pos": "122086677", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.01138", "site_lbl": "D1393", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs748339041", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748339041" }, { "id": "rs748339041", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs748339041" }, { "id": "rs748339041", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs748339041" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1399, "end_pos": 1399, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IAT->NAT).", "chr_id": "10", "chr_pos": "122086696", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1399", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1328109752", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1328109752" }, { "id": "rs1328109752", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1328109752" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 147, "end_pos": 147, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAP->NAS).", "chr_id": "10", "chr_pos": "122082939", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P147", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95359", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95359" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1848, "end_pos": 1848, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DET->NET).", "chr_id": "10", "chr_pos": "122088560", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D1848", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs762196038", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762196038" }, { "id": "rs762196038", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762196038" }, { "id": "rs762196038", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs762196038#frequency_tab" }, { "id": "rs762196038", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs762196038" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1900, "end_pos": 1900, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIS->NIS).", "chr_id": "10", "chr_pos": "122132734", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1900", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1251685959", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1251685959" }, { "id": "rs1251685959", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1251685959" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1942, "end_pos": 1942, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DLS->NLS).", "chr_id": "10", "chr_pos": "122143696", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D1942", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95359", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95359" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 195, "end_pos": 195, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DQS->NQS).", "chr_id": "10", "chr_pos": "122083083", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "D195", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1441479270", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1441479270" }, { "id": "rs1441479270", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1441479270" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 2227, "end_pos": 2227, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSP->NSS).", "chr_id": "10", "chr_pos": "122211104", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P2227", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs370847934", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370847934" }, { "id": "rs370847934", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370847934" }, { "id": "rs370847934", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs370847934#frequency_tab" }, { "id": "rs370847934", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs370847934" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 2312, "end_pos": 2312, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DNT->NNT).", "chr_id": "10", "chr_pos": "122211359", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D2312", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs868858086", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs868858086" }, { "id": "rs868858086", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs868858086" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 2418, "end_pos": 2418, "sequence_org": "P", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NKP->NKT).", "chr_id": "10", "chr_pos": "122211677", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P2418", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1243751002", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1243751002" }, { "id": "rs1243751002", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1243751002" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 2480, "end_pos": 2480, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KWT->NWT).", "chr_id": "10", "chr_pos": "122216722", 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": 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hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95359", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95359" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", 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"id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95359", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95359" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95359" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O95359", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95359" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "common_name": "Human" } ], "gene": [ { "name": "TACC2", "url": "https://www.uniprot.org/uniprot/O95359", "locus": { "chromosome": "10", "start_pos": 122254545, "end_pos": 121989163, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000138162", "url": "https://www.ensembl.org/id/ENSG00000138162" } ] } } ], "crossref": [ { "id": "ENSG00000138162", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000138162", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O95359", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95359", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "TACC2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TACC2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "10579", "url": "https://www.ncbi.nlm.nih.gov/gene/10579", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "11523", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11523", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O95359", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95359*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR007707", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007707", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:10579", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10579", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "605302", "url": "http://www.omim.org/entry/605302", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O95359", "url": "https://www.nextprot.org/entry/NX_O95359", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O95359", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95359", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "ECPPEAC", "url": "https://omabrowser.org/oma/group/ECPPEAC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5406887at2759", "url": "http://www.orthodb.org/?query=5406887at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13924", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13924", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13924:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13924:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05010", "url": "http://pfam.xfam.org/family/PF05010", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95359", "url": "https://pharos.nih.gov/targets/O95359", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95359", "url": "http://purl.obolibrary.org/obo/PR_O95359", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95359-1", "url": "https://www.uniprot.org/uniprot/O95359-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95359-2", "url": "https://www.uniprot.org/uniprot/O95359-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95359-3", "url": "https://www.uniprot.org/uniprot/O95359-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95359-4", "url": "https://www.uniprot.org/uniprot/O95359-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95359-5", "url": "https://www.uniprot.org/uniprot/O95359-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95359-6", "url": "https://www.uniprot.org/uniprot/O95359-6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 2948, "header": "sp|O95359-4|TACC2_HUMAN Isoform 4 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "isoforms": [ { "isoform_ac": "O95359-1", "url": "", "sequence": { "sequence": "MGGSQSLQPAPASDLNLEASEAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 1026, "header": "sp|O95359-1|TACC2_HUMAN Isoform 1 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "locus": { "chromosome": "10", "start_pos": 122254053, "end_pos": 122163925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000260733.7", "url": "https://www.ensembl.org/id/ENST00000260733.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000260733.3", "url": "https://www.ensembl.org/id/ENSP00000260733.3" } ] } }, { "isoform_ac": "O95359-2", "url": "", "sequence": { "sequence": "MPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEIREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 571, "header": "sp|O95359-2|TACC2_HUMAN Isoform 2 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "locus": { "chromosome": "10", "start_pos": 122254053, "end_pos": 122211314, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369000.5", "url": "https://www.ensembl.org/id/ENST00000369000.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000357996.1", "url": "https://www.ensembl.org/id/ENSP00000357996.1" } ] } }, { "isoform_ac": "O95359-3", "url": "", "sequence": { "sequence": "MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEIREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 2871, "header": "sp|O95359-3|TACC2_HUMAN Isoform 3 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "locus": {} }, { "isoform_ac": "O95359-4", "url": "", "sequence": { "sequence": "MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCTASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEGCLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPKEEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESRQGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYLTDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAGGSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPASSLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGEHPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPSESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQAFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLPHKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEKSDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPHPPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETSIFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSELQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSRVSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEAADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETEACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGDPGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPARELGGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSADPRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTEGPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEPSQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGKDLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGPAGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGLPSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAHTGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQSTPAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDLVLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEPDETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVSPSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 2948, "header": "sp|O95359-4|TACC2_HUMAN Isoform 4 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "locus": { "chromosome": "10", "start_pos": 122254053, "end_pos": 122021982, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000334433.7", "url": "https://www.ensembl.org/id/ENST00000334433.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000334280.2", "url": "https://www.ensembl.org/id/ENSP00000334280.2" } ] } }, { "isoform_ac": "O95359-5", "url": "", "sequence": { "sequence": "MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSSPVADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIALASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 1094, "header": "sp|O95359-5|TACC2_HUMAN Isoform 5 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "locus": { "chromosome": "10", "start_pos": 122254053, "end_pos": 122021982, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000513429.5", "url": "https://www.ensembl.org/id/ENST00000513429.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000425062.1", "url": "https://www.ensembl.org/id/ENSP00000425062.1" } ] } }, { "isoform_ac": "O95359-6", "url": "", "sequence": { "sequence": "MGGSQSLQPAPASDLNLEASEAMSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPEVSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDFDNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSSGNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEESLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGGGRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEIPASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPPVISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYRNSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEETEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFASADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIITKEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 996, "header": "sp|O95359-6|TACC2_HUMAN Isoform 6 of Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens OX=9606 GN=TACC2 PE=1 SV=3 CANONICAL=O95359-4" }, "locus": { "chromosome": "10", "start_pos": 122254053, "end_pos": 122163925, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000360561.7", "url": "https://www.ensembl.org/id/ENST00000360561.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000353763.3", "url": "https://www.ensembl.org/id/ENSP00000353763.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 979, "start_aa": "Ser", "end_pos": 979, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser979", "evidence": [ { "id": "O95359", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95359" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "phosphorylation": [ { "start_pos": 1025, "end_pos": 1025, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" } ], "site_lbl": "Ser1025" }, { "start_pos": 1267, "end_pos": 1267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" } ], "site_lbl": "Ser1267" }, { "start_pos": 1311, "end_pos": 1311, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser1311" }, { "start_pos": 1313, "end_pos": 1313, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" } ], "site_lbl": "Ser1313" }, { "start_pos": 1426, "end_pos": 1426, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr1426" }, { "start_pos": 1494, "end_pos": 1494, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" }, { "database": "PubMed", "id": "35494241", "url": "" } ], "site_lbl": "Ser1494" }, { "start_pos": 1562, "end_pos": 1562, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" } ], "site_lbl": "Ser1562" }, { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser161" }, { "start_pos": 1635, "end_pos": 1635, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O95359", "url": "http://phospho.elm.eu.org/byAccession/O95359.html" }, { "database": "iPTMnet", "id": "O95359", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95359" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser1635" }, { "start_pos": 164, "end_pos": 164, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { 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Tanaka Y, Ito Y, Ohmiya H, Hayashizaki Y, Takeda S, Itoh M, Kawaji H", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" } ], "reference": [ { "type": "PubMed", "id": "29074988", "url": "https://glygen.org/publication/PubMed/29074988" } ] }, { "title": "High expression of TACC2 in hepatocellular carcinoma is associated with poor prognosis.", "journal": "Cancer biomarkers : section A of Disease markers", "date": "2018", "authors": "Shakya M, Zhou A, Dai D, Zhong Q, Zhou Z, Zhang Y, Li X, Bholee AK, Chen M", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" } ], "reference": [ { "type": "PubMed", "id": "29843208", "url": "https://glygen.org/publication/PubMed/29843208" } ] }, { "title": "Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.", "journal": "JCI insight", "date": "2020", "authors": "Mallampalli RK, Li X, Jang JH, Kaminski T, Hoji A, Coon T, Chandra D, Welty S, Teng Y, Sembrat J, Rojas M, Zhao Y, Lafyatis R, Zou C, Sciurba F, Sundd P, Lan L, Nyunoya T", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" } ], "reference": [ { "type": "PubMed", "id": "31996486", "url": "https://glygen.org/publication/PubMed/31996486" } ] }, { "title": "Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter.", "journal": "Scientific reports", "date": "2021", "authors": "Ito Y, Terao Y, Noma S, Tagami M, Yoshida E, Hayashizaki Y, Itoh M, Kawaji H", "evidence": [ { "database": "RefSeq", "id": "NP_001278807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278807" } ], "reference": [ { "type": "PubMed", "id": "33931666", "url": "https://glygen.org/publication/PubMed/33931666" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95359", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95359" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "pathway": [ { "id": "hsa:10579", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10579", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K598-1", "protein_name": "Transforming, acidic coiled-coil containing protein 2", "gene_name": "Tacc2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGEKTLCFPQEDAVSYNTVLWPPNPDPPQRTSSVQSLRSLQPPGNSQTPQKQGDSPGSGAASTGLGASCSASESVASLDPSTVSPEVTKPGEHPQEARDPEDSPLPRSSLPWEQPYPSASMPFTEGLSEGCLANSEAEVPEDGPLTNHLRVEPSPNGPGDILLTFTPEVDGPAQRTVAARTPSAEGDQELKEEGQSSSSSCTGQSPGISFVPLQEPKTELLYGKGDWPRDFEFQRKDDIDNCSSPESVTKAPAATQPGMQNSAVLECPPKLETMVPQDSVLRSSDSKKGRSEVLPMDLAKHVEFLGGCHPSKGNSGANPGAGTSPASQESCQLRVGMPLPSAELPSGPQGLTTARADGGSWEETLDTSSAQSQPQTGTSGAEPQQVVCVPAASQPGGSLLLSAKAPGFTGTEERHTASSPTARLTAWSSTASEEPTEAVSETKMSVSADLAATGQMGPGVVELKPTSDLRRTQEQPPEGSCLQWVPAPFLQGRNDTIQEGLLLPPFSHQVSNESSRRSMGPTDDPKASKNTENRVVAREESIPHGDNRKGQQEATRALAGTELRNHDKEKSHAFRAKPRGDTEKDDISELHSNKENKIVPSSDSTQPPRQEVAESHMTDTATSLHEVHEEDPILSSASDGTGEHFLPQDAIWESSRLQTESSVMLQARGGLEATESLPVLESEKADALPATAMEEEAPRAAEMEDVLEVKKDHSPLHQPYSCAGQGLPMSPGQPCGLEKVEPGQEDHADTSSPPNGKNSTIGDGLTVPRLEQDGQRKLSCPEASLPPPLQNPLLSSQLDPDAAISAVLCDKDQSPTNGQRACLCGPGLKEQSTDPSPIPVSEEGKPWADVSLSTQGGKEQGSELPSKGSLCDTPSSSPKGTVLGGAPSEMSELSTPLGQELPALGGNEQENTGRNSQPSEIQPPSASLTGHSGGKDSFCVGQGLSKSQQELADALQTGSQREEARCGDSGISEATGVLPPPRGLEKIETASRNIAEAPPGPPDSVALLDTAYCSPDPVPTNPGVAPAHDALVSEACDESQKESVPQLDMEQRATLGPEEQSPLGSFRRAEEQDSKEGSAEVSVDASDGDPKMQQASEAPEAALSSGFFQADQSLPSTLKEPRQPAKLEPSCGDALLPAGESNGIPRSTVGVLTHRAVSGPQSLLPAEPPEETVPDTPYLHISGAAKKDAEDASMRAVFSEDPGAPHESPIKEPPPVENDTPGKSPAVSFTTDLQPGTAHGEISVAGDGDGIPQAGTTEGHVSLTPYLDRMPLLVRDEQVAREMHVAATPETNARPSETAVCPASEEAAGETGGSRERAVELTPDLMVVTSGSEGASSKQPSVIKGLPDFREHITKIFEQSVFGALAADRTHSVPSKKSGVPSSMLVEGPVISLDSGKLPDGVQGMAAAPLPVPPVGLQVEKKQESGVKAEVSHPVPQDPAPEKLMGLAEAALEESLPGAIVEGEVTRVPLTVTSERLEGTGEPGQGAQAHTQQARSRQELVVGLPSSKAVQGVPAEPAPGFPVDPQSHADADEASSQGDKSHSVKEYLETLPSNSPHGINGAQDSVHTKGPSNLLGSTCALDGSSPHGSVLNMPESNSEPWIPSTLGGERQLEAAVCTSDKQNVLENQDGPKMLAREVLAIPLGPSNMAGAAEEAEGDVTPSRPETWAEVSGDLLETGTTRMLPHEAGDSAPPGSYRDSGCSNRTQVMEDTATLPGDSQVGCQQAKEPLGPQLPAPYGKTSVSSPPEPDESSDEKLHLLAPEVLTDRKSPGPGSATSPSVLEIHAPKGSSAETRDLGGAESTSPSAAHASLAPVASEHAALASAAAGPGVETPTASCQHLAKNINRSSDSEEAFETPESTTPVKAPPAPPPPPPEVTPEPEVIEPPAPEEPGCISEPVVVPDGPRSESVEGSPFRPSHSSSAVFDEDKPIASSGTYNLDFDSIELVDNFQSLEPCSADYKGQECKVSTRRKSTESVPPSKTTLSRSLSLQASDFDGASCPGSPEAGTLATDACGTGSNSASSTLKRTKKTRPPSLKKKQATKKPTETPPVKETQQEPGEESPVPSEEHLAPETKTESATPEGTGCTLSEETSLESAAVPTATCPLTLESVEDVSPLVSGGGRVQNSPPVGRKSVPLTTASEAVEVTLPDGGGQEDLPAKGLSVRLEFDYSEDKGSWESQQENAPPTKKIGKKPVAKMPLRRPKLKKTPEKLDNTPASPPRSPAEPSDIPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPTLSQQSYNFDPDACEESLDPFKASSKTPSSPSKSPASFEIPASTIEADGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPEAPPVSTVVHATDEEKLAVTSQKWTCMTVDLDADKQDFPQPSDLSNFVNETKFNSPSEGKQLSGQPDPHLALENTDPRGQRPRKDSCQPELDYRNSYEIEYMEKLGSSLPQDDDTPKKQALYLMFDTPQESPVKSPPVRMSDSPTPCSGSSFEDTEALVNATAKLQHPVPRGLASNQEPLLQLPEKSSQKELEAMALGTPAEAIEITAPEGAFASADALLSRLAHPASLCGALGYLEPDLAEKNPPVFAQKLQEELEFAVMRIEALKLARQIALASRSRQDTKREATHPPDVSISKTTLYSRIGPTEVEKPPGLLFQQPDLDSALQVARAEVIAKEREVSEWRDKYEESRREVVEMRKIVAEYEKTIAQMIEDEQREKSISHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKKCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAYQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 2875 }, "evidence": [ { "id": "45932127", "url": "http://www.informatics.jax.org/homology/45932127", "database": "MGI" }, { "id": "O95359", "url": "https://omabrowser.org/oma/group/O95359/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JJG0-1", "protein_name": "Transforming acidic coiled-coil-containing protein 2", "gene_name": "Tacc2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGNENSTSDHQRTSSVQSPRSLQPPGKSQSLQKQQGDLPGSCAGSIPGTDDVIQPAAPVDPGHPPLAGIGSNQGEVCTSLQLSYTIVTVQSASPSAARASPAPLAPEHTASAPSAAGPGVEVTPTGSPQHLAKNEPRSSDSEEAFETPESTTPVKAPPAPPPPPPEVTPEPEVIDPPAPEEPGCISEPPVVVPDGPRSSESVEGSPFRPSHSSSAVFDEDKPIASSGTYNLDFDSIELVDNFQSLEPCSADSKGQECKVSTRRKSTESVPPSKSTLSRSLSLQASDFDGASCPGSPEAGTLTTDACGTGSNSASSTLKRTKKTRPPSLKKKQATKKPTETPPVKETQQEPGEESPVPSEEHLAPETKTESATPEGAGCTLSDDTPLESPAVPTATCPLTLESAEDVSPLVSGGGRVQNSPPVGRKSVPLTTASEAVEVTLSDSGGQEDLPAKGLSVRLEFDYSEDKGSWESQQENAPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPTEPSDTPIAKGTYTFDIDKWDDPNFNPFSSTSKMQESPKLSQQSYNFDPDACEESLDPFKASSKTPSSPSKSPASFEIPASTTEADGDGLNKPAKKKKTPLKTMVEDVMSVCSLFDTFRVKKSPKRSPLSDPPSQDPTPAATPEAPSAISTVVHATDEEKLAVTSQKWTCMTVDLDADKQDFPQPSDLSNFVNETKFNSPSEELDYRNSYEIEYMEKLGSSLPQDDDTPKKQALYLMFDTPQESPVKSPPVRMSDSPTPCSGSSFEDTEALVNAATKLQHPVARGLPSSQEPLLQVPEKPSQKELEAMALGTPAEAIEITAPEGAFASADTLLSRLAHPASLCGALGYLEPDLAEKNPPVFAQKLQEELEFAVMRIEALKLARQIALASRSRQDTKREAAHPPDVSISKTALYSRIGSTEVEKPPGLLFQQPDLDSALQVARAEVIAKEREVSEWRDKYEESRREVVEMRKIVAEYEKTIAQMIPGTERKILSHQTVQQLVLEKEQALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKKCAQEYLSRVKKEEQRYQALKVHAEEKLDRANAEIAQVRGKAQQEQAAYQASLRKEQLRVDALERTLEQKNKEIEELTKICDELIAKMGKS", "length": 1149 }, "evidence": [ { "id": "45932127", "url": "http://www.informatics.jax.org/homology/45932127", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "microtubule cytoskeleton organization", "id": "GO:0000226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "nuclear receptor binding", "id": "GO:0016922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1677, "end_pos": 1679, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2506, "end_pos": 2508, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 977, "end_pos": 979, "annotation": "n_glycosylation_sequon" }, { "start_pos": 991, "end_pos": 993, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated by TTK; which is required for localization in centrosome.", "evidence": [ { "database": "UniProtKB", "id": "O95359", "url": "https://www.uniprot.org/uniprot/O95359" }, { "database": "PubMed", "id": "15304323", "url": "https://glygen.org/publication/PubMed/15304323" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 979 ], "snv_sites": [ 135, 147, 195, 328, 540, 569, 606, 788, 888, 915, 971, 1209, 1311, 1356, 1393, 1399, 1848, 1900, 1942, 2227, 2312, 2418, 2480, 2509, 2588 ], "glycation_sites": [], "phosphorylation_sites": [ 161, 164, 197, 201, 269, 325, 493, 561, 569, 571, 575, 758, 962, 1025, 1267, 1311, 1313, 1426, 1494, 1562, 1635, 1946, 1949, 2072, 2073, 2075, 2088, 2092, 2122, 2161, 2226, 2246, 2250, 2256, 2307, 2314, 2317, 2321, 2359, 2373, 2377, 2389, 2390, 2392, 2394, 2403, 2428, 2430, 2443, 2451, 2455, 2458, 2512, 2534, 2553, 2557, 2569, 2571, 2576, 2577, 2625 ], "sequon_annotation_sites": [ { "start_pos": 1677, "end_pos": 1679 }, { "start_pos": 2506, "end_pos": 2508 }, { "start_pos": 5, "end_pos": 7 }, { "start_pos": 977, "end_pos": 979 }, { "start_pos": 991, "end_pos": 993 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 61 }, { "field": "total_sites", "count": 61 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 25 }, { "field": "total_sites", "count": 25 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 18 }, { "field": "total_sites", "count": 18 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 20 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }