{ "uniprot_canonical_ac": "O95273-1", "uniprot_ac": "O95273", "uniprot_id": "CCDB1_HUMAN", "mass": { "chemical_mass": 40262.0, "monoisotopic_mass": 40262.0 }, "refseq": { "ac": "NP_036274", "name": "cyclin-D1-binding protein 1", "summary": "This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274" }, "gene_names": [ { "name": "CCNDBP1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95273", "id": "O95273" }, { "name": "CCNDBP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274", "id": "NP_036274" }, { "name": "DIP1; GCIP; HHM", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274", "id": "NP_036274" }, { "name": "DIP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95273", "id": "O95273" }, { "name": "GCIP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95273", "id": "O95273" }, { "name": "HHM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95273", "id": "O95273" } ], "protein_names": [ { "name": "Cyclin-D1-binding protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95273" }, { "name": "Grap2 and cyclin-D-interacting protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95273" }, { "name": "Human homolog of Maid", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95273" }, { "name": "cyclin-D1-binding protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274", "id": "NP_036274" }, { "name": "human homolog of Maid; grap2 and cyclin-D-interacting protein; cyclin D-type binding-protein 1; D-type cyclin-interacting protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274", "id": "NP_036274" } ], "function": [ { "annotation": "Grap2 cyclin D interacting protein negatively regulates CREBbinding protein, inhibiting fibroblastlike synoviocyte growth.", "evidence": [ { "database": "RefSeq", "id": "NP_036274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274" }, { "database": "PubMed", "id": "33576455", "url": "https://glygen.org/publication/PubMed/33576455" } ] }, { "annotation": "May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273#function" }, { "database": "PubMed", "id": "10801854", "url": "https://glygen.org/publication/PubMed/10801854" } ] }, { "annotation": "Rs66651343 and rs12909095 confer lung cancer risk by regulating CCNDBP1 expression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_036274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274" }, { "database": "PubMed", "id": "37058478", "url": "https://glygen.org/publication/PubMed/37058478" } ] }, { "annotation": "This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_036274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "93.32", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "91.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "95.46", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "96.59", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "95.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "95.9", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "95.01", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "87.67", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "94.96", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "95.08", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000166946", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166946" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95273", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95273" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"url": "", "sequence": { "sequence": "MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRGNPEVL", "length": 42, "header": "tr|H3BUF4-1|CCDB1_HUMAN Computationally mapped isoform of Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=1 CANONICAL=O95273-1" }, "locus": { "chromosome": "15", "start_pos": 43189215, "end_pos": 43185499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000569745.5", "url": "https://www.ensembl.org/id/ENST00000569745.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000456839.1", "url": "https://www.ensembl.org/id/ENSP00000456839.1" } ] } }, { "isoform_ac": "O95273-1", "url": "", "sequence": { "sequence": "MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAAVTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL", "length": 360, "header": "sp|O95273-1|CCDB1_HUMAN Isoform 1 of Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2 CANONICAL=O95273-1" }, "locus": { "chromosome": "15", "start_pos": 43194838, "end_pos": 43185499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000300213.9", "url": "https://www.ensembl.org/id/ENST00000300213.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000300213.4", "url": "https://www.ensembl.org/id/ENSP00000300213.4" } ] } }, { "isoform_ac": "O95273-2", "url": "", "sequence": { "sequence": "MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAAVTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINEP", "length": 309, "header": "sp|O95273-2|CCDB1_HUMAN Isoform 2 of Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2 CANONICAL=O95273-1" }, "locus": { "chromosome": "15", "start_pos": 43194086, "end_pos": 43185499, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000565296.5", "url": "https://www.ensembl.org/id/ENST00000565296.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000455419.1", "url": "https://www.ensembl.org/id/ENSP00000455419.1" } ] } }, { "isoform_ac": "O95273-3", "url": "", "sequence": { "sequence": "MAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL", "length": 232, "header": "sp|O95273-3|CCDB1_HUMAN Isoform 3 of Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2 CANONICAL=O95273-1" }, "locus": {} }, { "isoform_ac": "O95273-4", "url": "", "sequence": { "sequence": "MAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINVSTGFEGIATEQMGRISLITSISCK", "length": 204, "header": "sp|O95273-4|CCDB1_HUMAN Isoform 4 of Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2 CANONICAL=O95273-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity.", "journal": "The Journal of biological chemistry", "date": "2000-07-07", "authors": "Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "10801854", "url": "https://glygen.org/publication/PubMed/10801854" } ] }, { "title": "Cloning and characterization of DIP1, a novel protein that is related to the Id family of proteins.", "journal": "Experimental cell research", "date": "2000", "authors": "Yao Y, Doki Y, Jiang W, Imoto M, Venkatraj VS, Warburton D, Santella RM, Lu B, Yan L, Sun XH, Su T, Luo J, Weinstein IB", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "10854051", "url": "https://glygen.org/publication/PubMed/10854051" } ] }, { "title": "Human homologue of maid: a dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression.", "journal": "Hepatology", "date": "2000", "authors": "Terai S, Aoki H, Ashida K, Thorgeirsson SS", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "10915743", "url": "https://glygen.org/publication/PubMed/10915743" } ] }, { "title": "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Hu R M, Han Z G, Song H D, Peng Y D, Huang Q H, Ren S X, Gu Y J, Huang C H, Li Y B, Jiang C L, Fu G, Zhang Q H, Gu B W, Dai M, Mao Y F, Gao G F, Rong R, Ye M, Zhou J, Xu S H, Gu J, Shi J X, Jin W R, Zhang C K, Wu T M, Huang G Y, Chen Z, Chen M D, Chen J L", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "10931946", "url": "https://glygen.org/publication/PubMed/10931946" } ] }, { "title": "p29, a novel GCIP-interacting protein, localizes in the nucleus.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2000", "authors": "Chang MS, Chang CL, Huang CJ, Yang YC", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "11118353", "url": "https://glygen.org/publication/PubMed/11118353" } ] }, { "title": "Human homologue of maid is a useful marker protein in hepatocarcinogenesis.", "journal": "Gastroenterology", "date": "2005", "authors": "Takami Taro, Terai Shuji, Yokoyama Yuichiro, Tanimoto Haruko, Tajima Kunihiko, Uchida Koichi, Yamasaki Takahiro, Sakaida Isao, Nishina Hiroshi, Thorgeirsson Snorri S, Okita Kiwamu", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "15887118", "url": "https://glygen.org/publication/PubMed/15887118" } ] }, { "title": "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.", "journal": "DNA Res.", "date": "2005", "authors": "Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "16303743", "url": "https://glygen.org/publication/PubMed/16303743" } ] }, { "title": "GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis.", "journal": "J. Cell. Biochem.", "date": "2007", "authors": "Ma Wenbin, Stafford Lewis J, Li Dali, Luo Jian, Li Xiaoying, Ning Guang, Liu Mingyao", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "17131381", "url": "https://glygen.org/publication/PubMed/17131381" } ] }, { "title": "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells.", "journal": "Oncogene", "date": "2008", "authors": "Chang TW, Chen CC, Chen KY, Su JH, Chang JH, Chang MC", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "reference": [ { "type": "PubMed", "id": "17621266", "url": "https://glygen.org/publication/PubMed/17621266" } ] }, { "title": "Grap2 cyclin D interacting protein negatively regulates CREBbinding protein, inhibiting fibroblastlike synoviocyte growth.", "journal": "Molecular medicine reports", "date": "2021", "authors": "Fujita H, Aratani S, Nakajima T", "evidence": [ { "database": "RefSeq", "id": "NP_036274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274" } ], "reference": [ { "type": "PubMed", "id": "33576455", "url": "https://glygen.org/publication/PubMed/33576455" } ] }, { "title": "rs66651343 and rs12909095 confer lung cancer risk by regulating CCNDBP1 expression.", "journal": "PloS one", "date": "2023", "authors": "Shi Qiang, Ruan Ji, Yang Yu-Chen, Shi Xiao-Qian, Liu Shao-Dong, Wang Hong-Yan, Zhang Shi-Jiao, Wang Si-Qi, Zhong Li, Sun Chang", "evidence": [ { "database": "RefSeq", "id": "NP_036274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036274" } ], "reference": [ { "type": "PubMed", "id": "37058478", "url": "https://glygen.org/publication/PubMed/37058478" } ] } ], "pathway": [ { "id": "hsa:23582", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23582", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TVC7-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASSTAAVPFLAPPLEQLRHLAEELRSLLPRVRVGEAQETAEEFNREMFWRRLNEAAVKVNGEATVLTTHFSKLPWPSPQETQRICEQVRIAIEEIIIVYYSLPKDQGITLRKLVRNAALDIVDGMAQLLEVLLTAPSQSTENGDLISCNSVSVACQQVPEIPKDNKAAALLMLTKSVDFVKDAHEEMEQAVEECDPYSGLLNDSEDNSDSHSDEDGVLGLPSNRDSYWSEEDQELIIPCLALVRASRASLKKIRILVAENGKKDEVAQLDDIVDISDEISPSVDDLVLSIYPPVCHLTVRISSAKLVSVLIKALEITKASHVSPHPGDSWIPLLINAVDHCMNRIKALTQRAAEL", "length": 356 }, "evidence": [ { "id": "45931667", "url": "http://www.informatics.jax.org/homology/45931667", "database": "MGI" }, { "id": "O95273", "url": "https://omabrowser.org/oma/group/O95273/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q5BK06-1", "protein_name": "Cyclin-D1-binding protein 1", "gene_name": "Ccndbp1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASSTTPVSFLAPPLEQLRHLAEELRSLLPRVRVGEAQETAEEFNREMFWRRLNEAAMKVSGEATVLTTLFSKIPSPSPQETQRICEQVHIATEEVIAAYYTFPKDQGITLRKLVRNAVLDIVDGTAQLLDALLAAPSQSPENGDLISCNSVSVACQQVAEIPKDNKAAALLMLTKSVDLVKDAHEEMEQAVEECDPYCGLLDDSEDNSDSHHNEDGVGLPSNRDSYWSEEDQALITPCLALVRASRASLKKIRILVAENGRKDQVAQLDDIVDISDEISPSVDDLVLSVYPPVCHLTVRITSAKLVSVLIKALEITKASHVSPQPGDSWIPLLINAVDHCMDRIKELTQRAVEL", "length": 355 }, "evidence": [ { "id": "45931667", "url": "http://www.informatics.jax.org/homology/45931667", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of cell cycle", "id": "GO:0051726", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051726", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 206, "end_pos": 208, "annotation": "n_glycosylation_sequon" }, { "start_pos": 211, "end_pos": 213, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated.", "evidence": [ { "database": "UniProtKB", "id": "O95273", "url": "https://www.uniprot.org/uniprot/O95273" }, { "database": "PubMed", "id": "10854051", "url": "https://glygen.org/publication/PubMed/10854051" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 206, "end_pos": 208 }, { "start_pos": 211, "end_pos": 213 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }