{ "uniprot_canonical_ac": "O95271-1", "uniprot_ac": "O95271", "uniprot_id": "TNKS1_HUMAN", "mass": { "chemical_mass": 142039.0, "monoisotopic_mass": 142039.0 }, "refseq": { "ac": "NP_003738", "name": "poly [ADP-ribose] polymerase tankyrase-1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" }, "gene_names": [ { "name": "TNKS", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95271", "id": "O95271" }, { "name": "ARTD5; PARP-5a; PARP5A; PARPL; pART5; TIN1; TINF1; TNKS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738", "id": "NP_003738" }, { "name": "PARP5A", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95271", "id": "O95271" }, { "name": "PARPL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95271", "id": "O95271" }, { "name": "TIN1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95271", "id": "O95271" }, { "name": "TINF1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95271", "id": "O95271" }, { "name": "TNKS1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95271", "id": "O95271" }, { "name": "TNKS", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738", "id": "NP_003738" } ], "protein_names": [ { "name": "Poly [ADP-ribose] polymerase tankyrase-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95271" }, { "name": "2.4.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "2.4.2.30", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "ADP-ribosyltransferase diphtheria toxin-like 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "ARTD5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "Poly [ADP-ribose] polymerase 5A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "Protein poly-ADP-ribosyltransferase tankyrase-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "TANK1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "TNKS-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "TRF1-interacting ankyrin-related ADP-ribose polymerase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "Tankyrase I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "Tankyrase-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95271" }, { "name": "poly [ADP-ribose] polymerase tankyrase-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738", "id": "NP_003738" }, { "name": "tankyrase-1; TANK1; TNKS-1; tankyrase I; poly [ADP-ribose] polymerase 5A; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; ADP-ribosyltransferase diphtheria toxin-like 5; TRF1-interacting ankyrin-related ADP-ribose polymerase 1; protein poly-ADP-ribosyltransferase tankyrase-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738", "id": "NP_003738" } ], "function": [ { "annotation": "Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" }, { "database": "PubMed", "id": "35450028", "url": "https://glygen.org/publication/PubMed/35450028" } ] }, { "annotation": "Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers.", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" }, { "database": "PubMed", "id": "36603485", "url": "https://glygen.org/publication/PubMed/36603485" } ] }, { "annotation": "Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation (PubMed:19759537, PubMed:21478859). Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination (PubMed:21478859). Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length (PubMed:11739745). Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI (PubMed:22864114). May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles (PubMed:10988299). May be involved in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287). Stimulates 26S proteasome activity (PubMed:23622245).", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271#function" }, { "database": "PubMed", "id": "22864114", "url": "https://glygen.org/publication/PubMed/22864114" }, { "database": "PubMed", "id": "19759537", "url": "https://glygen.org/publication/PubMed/19759537" }, { "database": "PubMed", "id": "23622245", "url": "https://glygen.org/publication/PubMed/23622245" }, { "database": "PubMed", "id": "21478859", "url": "https://glygen.org/publication/PubMed/21478859" }, { "database": "PubMed", "id": "11739745", "url": "https://glygen.org/publication/PubMed/11739745" }, { "database": "PubMed", "id": "10988299", "url": "https://glygen.org/publication/PubMed/10988299" }, { "database": "PubMed", "id": "16076287", "url": "https://glygen.org/publication/PubMed/16076287" }, { "database": "PubMed", "id": "25043379", "url": "https://glygen.org/publication/PubMed/25043379" } ] }, { "annotation": "Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" }, { "database": "PubMed", "id": "34876695", "url": "https://glygen.org/publication/PubMed/34876695" } ] }, { "annotation": "Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" }, { "database": "PubMed", "id": "35733260", "url": "https://glygen.org/publication/PubMed/35733260" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 1184, "end_pos": 1184, "sequence_org": "H", "sequence_mut": "A", "comment": "Loss of activity; when associated with A-1291.", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "PubMed", "id": "11739745", "url": "https://glygen.org/publication/PubMed/11739745" } ] }, { "start_pos": 1291, "end_pos": 1291, "sequence_org": "E", "sequence_mut": "A", "comment": "Loss of activity; when associated with A-1184.", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "PubMed", "id": "11739745", "url": "https://glygen.org/publication/PubMed/11739745" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "75.9", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "76.56", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "83.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "73.42", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "83.64", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "82", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "65.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "85.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "83.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "74.97", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "86.24", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "82.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "84.08", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "O95271", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95271" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "common_name": "Human" } ], "gene": [ { "name": "TNKS", "url": "https://www.uniprot.org/uniprot/O95271", "locus": { "chromosome": "8", "start_pos": 9782346, "end_pos": 9555912, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000173273", "url": "https://www.ensembl.org/id/ENSG00000173273" } ] } } ], "crossref": [ { "id": "ENSG00000173273", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173273", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.4.2.30", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.2.30&UniProtAcc=O95271", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01438", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01438", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09524", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09524", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL6164", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL6164", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "TNKS", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TNKS", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "8658", "url": "https://www.ncbi.nlm.nih.gov/gene/8658", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "11941", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11941", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "E7EQ52", "url": "https://www.ebi.ac.uk/intact/interactors/id:E7EQ52*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "O95271", "url": "https://www.ebi.ac.uk/intact/interactors/id:O95271*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001660", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013761", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:8658", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8658", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603303", "url": "http://www.omim.org/entry/603303", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O95271", "url": "https://www.nextprot.org/entry/NX_O95271", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O95271", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95271", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "CPDGKRK", "url": "https://omabrowser.org/oma/group/CPDGKRK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5477658at2759", "url": "http://www.orthodb.org/?query=5477658at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189:SF50", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189:SF50", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24189:SF66", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24189:SF66", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2RF5", "url": "https://www.rcsb.org/structure/2RF5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3UDD", "url": "https://www.rcsb.org/structure/3UDD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3UH2", "url": "https://www.rcsb.org/structure/3UH2", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "3UH4", "url": "https://www.rcsb.org/structure/3UH4", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4DVI", "url": "https://www.rcsb.org/structure/4DVI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4I9I", "url": "https://www.rcsb.org/structure/4I9I", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4K4E", "url": "https://www.rcsb.org/structure/4K4E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4K4F", "url": "https://www.rcsb.org/structure/4K4F", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4KRS", "url": "https://www.rcsb.org/structure/4KRS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4LI6", "url": "https://www.rcsb.org/structure/4LI6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4LI7", "url": "https://www.rcsb.org/structure/4LI7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4LI8", "url": "https://www.rcsb.org/structure/4LI8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4MSG", "url": "https://www.rcsb.org/structure/4MSG", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4MSK", "url": "https://www.rcsb.org/structure/4MSK", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4MT9", "url": "https://www.rcsb.org/structure/4MT9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4N3R", "url": "https://www.rcsb.org/structure/4N3R", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4N4V", "url": "https://www.rcsb.org/structure/4N4V", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4OA7", "url": "https://www.rcsb.org/structure/4OA7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TOR", "url": "https://www.rcsb.org/structure/4TOR", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4TOS", "url": "https://www.rcsb.org/structure/4TOS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4U6A", "url": "https://www.rcsb.org/structure/4U6A", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4UUH", "url": "https://www.rcsb.org/structure/4UUH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4UW1", "url": "https://www.rcsb.org/structure/4UW1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4W5S", "url": "https://www.rcsb.org/structure/4W5S", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4W6E", "url": "https://www.rcsb.org/structure/4W6E", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5EBT", "url": "https://www.rcsb.org/structure/5EBT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ECE", "url": "https://www.rcsb.org/structure/5ECE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5ETY", "url": "https://www.rcsb.org/structure/5ETY", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5GP7", "url": "https://www.rcsb.org/structure/5GP7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5JHQ", "url": "https://www.rcsb.org/structure/5JHQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5JTI", "url": "https://www.rcsb.org/structure/5JTI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5JU5", "url": "https://www.rcsb.org/structure/5JU5", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5KNI", "url": "https://www.rcsb.org/structure/5KNI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6QXU", "url": "https://www.rcsb.org/structure/6QXU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6URQ", "url": "https://www.rcsb.org/structure/6URQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KKM", "url": "https://www.rcsb.org/structure/7KKM", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KKN", "url": "https://www.rcsb.org/structure/7KKN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KKO", "url": "https://www.rcsb.org/structure/7KKO", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KKP", "url": "https://www.rcsb.org/structure/7KKP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7KKQ", "url": "https://www.rcsb.org/structure/7KKQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7OCV", "url": "https://www.rcsb.org/structure/7OCV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00023", "url": "http://pfam.xfam.org/family/PF00023", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00644", "url": "http://pfam.xfam.org/family/PF00644", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "http://pfam.xfam.org/family/PF07647", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12796", "url": "http://pfam.xfam.org/family/PF12796", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13637", "url": "http://pfam.xfam.org/family/PF13637", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13857", "url": "http://pfam.xfam.org/family/PF13857", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O95271", "url": "https://pharos.nih.gov/targets/O95271", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95271", "url": "http://purl.obolibrary.org/obo/PR_O95271", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5545619", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5545619", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "54424", "url": "https://www.rhea-db.org/rhea/54424", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "58224", "url": "https://www.rhea-db.org/rhea/58224", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0C4DGE3", "url": "https://www.uniprot.org/uniprot/A0A0C4DGE3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0C4DGE3-1", "url": "https://www.uniprot.org/uniprot/A0A0C4DGE3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AA34QVM1", "url": "https://www.uniprot.org/uniprot/A0AA34QVM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0AA34QVM1-1", "url": "https://www.uniprot.org/uniprot/A0AA34QVM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E5RHD2", "url": "https://www.uniprot.org/uniprot/E5RHD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E5RHD2-1", "url": "https://www.uniprot.org/uniprot/E5RHD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EQ52", "url": "https://www.uniprot.org/uniprot/E7EQ52", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EQ52-1", "url": "https://www.uniprot.org/uniprot/E7EQ52-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EWY6", "url": "https://www.uniprot.org/uniprot/E7EWY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EWY6-1", "url": "https://www.uniprot.org/uniprot/E7EWY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAW5", "url": "https://www.uniprot.org/uniprot/H0YAW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YAW5-1", "url": "https://www.uniprot.org/uniprot/H0YAW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95271-1", "url": "https://www.uniprot.org/uniprot/O95271-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95271-2", "url": "https://www.uniprot.org/uniprot/O95271-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1327, "header": "sp|O95271-1|TNKS1_HUMAN Isoform 1 of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2 CANONICAL=O95271-1" }, "isoforms": [ { "isoform_ac": "A0A0C4DGE3-1", "url": "", "sequence": { "sequence": "GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYG", "length": 68, "header": "tr|A0A0C4DGE3-1|TNKS1_HUMAN Computationally mapped isoform of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=1 CANONICAL=O95271-1" }, "locus": { "chromosome": "8", "start_pos": 9735486, "end_pos": 9734991, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000518635.2", "url": "https://www.ensembl.org/id/ENST00000518635.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000431098.1", "url": "https://www.ensembl.org/id/ENSP00000431098.1" } ] } }, { "isoform_ac": "A0AA34QVM1-1", "url": "", "sequence": { "sequence": "XSYGSDPSIISLQGFTAAQMGNEAVQQILSGHS", "length": 33, "header": "tr|A0AA34QVM1-1|TNKS1_HUMAN Computationally mapped isoform of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=1 CANONICAL=O95271-1" }, "locus": {} }, { "isoform_ac": "E5RHD2-1", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGQRLLNCLLRVMGLGAGSG", "length": 243, "header": "tr|E5RHD2-1|E5RHD2_HUMAN Computationally mapped isoform of Tankyrase OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=1 CANONICAL=O95271-1" }, "locus": { "chromosome": "8", "start_pos": 9556668, "end_pos": 9555940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522110.1", "url": "https://www.ensembl.org/id/ENST00000522110.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000430920.1", "url": "https://www.ensembl.org/id/ENSP00000430920.1" } ] } }, { "isoform_ac": "E7EQ52-1", "url": "", "sequence": { "sequence": "MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1090, "header": "tr|E7EQ52-1|TNKS1_HUMAN Computationally mapped isoform of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=1 CANONICAL=O95271-1" }, "locus": { "chromosome": "8", "start_pos": 9776733, "end_pos": 9580197, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000518281.5", "url": "https://www.ensembl.org/id/ENST00000518281.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000429890.1", "url": "https://www.ensembl.org/id/ENSP00000429890.1" } ] } }, { "isoform_ac": "E7EWY6-1", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKVRHTPEQSARLSTEQPAALNTASLSPIFLKKLIL", "length": 617, "header": "tr|E7EWY6-1|TNKS1_HUMAN Computationally mapped isoform of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=1 CANONICAL=O95271-1" }, "locus": { "chromosome": "8", "start_pos": 9710322, "end_pos": 9555940, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000520408.5", "url": "https://www.ensembl.org/id/ENST00000520408.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428299.1", "url": "https://www.ensembl.org/id/ENSP00000428299.1" } ] } }, { "isoform_ac": "H0YAW5-1", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQVDTLKARHLCSIPAKNT", "length": 1316, "header": "tr|H0YAW5-1|TNKS1_HUMAN Computationally mapped isoform of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2 CANONICAL=O95271-1" }, "locus": {} }, { "isoform_ac": "O95271-1", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1327, "header": "sp|O95271-1|TNKS1_HUMAN Isoform 1 of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2 CANONICAL=O95271-1" }, "locus": { "chromosome": "HG76_PATCH", "start_pos": 3795529, "end_pos": 3572330, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646522.2", "url": "https://www.ensembl.org/id/ENST00000646522.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000493602.2", "url": "https://www.ensembl.org/id/ENSP00000493602.2" } ] } }, { "isoform_ac": "O95271-2", "url": "", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSGHS", "length": 643, "header": "sp|O95271-2|TNKS1_HUMAN Isoform 2 of Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2 CANONICAL=O95271-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O95271", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95271" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [ { "start_pos": 978, "end_pos": 978, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95271", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95271" }, { "database": "PubMed", "id": "17026964", "url": "https://glygen.org/publication/PubMed/17026964" } ], "site_lbl": "Ser978" }, { "start_pos": 982, "end_pos": 982, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95271", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95271" }, { "database": "PubMed", "id": "17026964", "url": "https://glygen.org/publication/PubMed/17026964" } ], "site_lbl": "Thr982" }, { "start_pos": 987, "end_pos": 987, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95271", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95271" }, { "database": "PubMed", "id": "17026964", "url": "https://glygen.org/publication/PubMed/17026964" } ], "site_lbl": "Ser987" }, { "start_pos": 991, "end_pos": 991, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95271", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95271" }, { "database": "PubMed", "id": "17026964", "url": "https://glygen.org/publication/PubMed/17026964" } ], "site_lbl": "Ser991" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "beta-catenin can be transported into the nucleus in a Ran-unassisted manner.", "journal": "Molecular biology of the cell", "date": "1999", "authors": "Yokoya F, Imamoto N, Tachibana T, Yoneda Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "10198061", "url": "https://glygen.org/publication/PubMed/10198061" } ] }, { "title": "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases.", "journal": "Genomics", "date": "1999", "authors": "Baker RT, Wang XW, Woollatt E, White JA, Sutherland GR", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "10444327", "url": "https://glygen.org/publication/PubMed/10444327" } ] }, { "title": "Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes.", "journal": "J. Cell Sci.", "date": "1999", "authors": "Smith S, de Lange T", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "10523501", "url": "https://glygen.org/publication/PubMed/10523501" } ] }, { "title": "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Kato M, Miyazawa K, Kitamura N", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "10982817", "url": "https://glygen.org/publication/PubMed/10982817" } ] }, { "title": "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Chi NW, Lodish HF", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "10988299", "url": "https://glygen.org/publication/PubMed/10988299" } ] }, { "title": "LDL-receptor-related proteins in Wnt signal transduction.", "journal": "Nature", "date": "2000", "authors": "Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "11029007", "url": "https://glygen.org/publication/PubMed/11029007" } ] }, { "title": "The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Torres J, Pulido R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "11035045", "url": "https://glygen.org/publication/PubMed/11035045" } ] }, { "title": "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.", "journal": "Nature", "date": "2001", "authors": "Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "11357136", "url": "https://glygen.org/publication/PubMed/11357136" } ] }, { "title": "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.", "journal": "Current biology : CB", "date": "2001", "authors": "Semenov MV, Tamai K, Brott BK, Kuhl M, Sokol S, He X", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "11448771", "url": "https://glygen.org/publication/PubMed/11448771" } ] }, { "title": "Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan.", "journal": "Development (Cambridge, England)", "date": "2001", "authors": "Tolwinski NS, Wieschaus E", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "11493532", "url": "https://glygen.org/publication/PubMed/11493532" } ] }, { "title": "A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.", "journal": "The EMBO journal", "date": "2001", "authors": "Borodovsky A, Kessler BM, Casagrande R, Overkleeft HS, Wilkinson KD, Ploegh HL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "11566882", "url": "https://glygen.org/publication/PubMed/11566882" } ] }, { "title": "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Cook BD, Dynek JN, Chang W, Shostak G, Smith S", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "11739745", "url": "https://glygen.org/publication/PubMed/11739745" } ] }, { "title": "Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.", "journal": "Nature", "date": "2002", "authors": "Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "11923872", "url": "https://glygen.org/publication/PubMed/11923872" } ] }, { "title": "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Sbodio JI, Chi NW", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "12080061", "url": "https://glygen.org/publication/PubMed/12080061" } ] }, { "title": "Ligand receptor interactions in the Wnt signaling pathway in Drosophila.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Wu CH, Nusse R", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "12205098", "url": "https://glygen.org/publication/PubMed/12205098" } ] }, { "title": "The ins and outs of APC and beta-catenin nuclear transport.", "journal": "EMBO reports", "date": "2002", "authors": "Henderson BR, Fagotto F", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "12223464", "url": "https://glygen.org/publication/PubMed/12223464" } ] }, { "title": "Direct identification of PTEN phosphorylation sites.", "journal": "FEBS letters", "date": "2002", "authors": "Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "12297295", "url": "https://glygen.org/publication/PubMed/12297295" } ] }, { "title": "POT1 as a terminal transducer of TRF1 telomere length control.", "journal": "Nature", "date": "2003", "authors": "Loayza D, De Lange T", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "12768206", "url": "https://glygen.org/publication/PubMed/12768206" } ] }, { "title": "CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.", "journal": "Nature", "date": "2003", "authors": "Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "12917689", "url": "https://glygen.org/publication/PubMed/12917689" } ] }, { "title": "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.", "journal": "Nature", "date": "2003", "authors": "Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "12917691", "url": "https://glygen.org/publication/PubMed/12917691" } ] }, { "title": "Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.", "journal": "Molecular cell", "date": "2003", "authors": "Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D, Mlodzik M, Shi DL, Zheng J", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "14636582", "url": "https://glygen.org/publication/PubMed/14636582" } ] }, { "title": "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.", "journal": "Nature immunology", "date": "2004", "authors": "Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "14661020", "url": "https://glygen.org/publication/PubMed/14661020" } ] }, { "title": "Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Cong F, Varmus H", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "14981260", "url": "https://glygen.org/publication/PubMed/14981260" } ] }, { "title": "A dynamic role of HAUSP in the p53-Mdm2 pathway.", "journal": "Molecular cell", "date": "2004", "authors": "Li M, Brooks CL, Kon N, Gu W", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "15053880", "url": "https://glygen.org/publication/PubMed/15053880" } ] }, { "title": "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.", "journal": "Development (Cambridge, England)", "date": "2004", "authors": "He X, Semenov M, Tamai K, Zeng X", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "15084453", "url": "https://glygen.org/publication/PubMed/15084453" } ] }, { "title": "Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function.", "journal": "Nature cell biology", "date": "2004", "authors": "Townsley FM, Cliffe A, Bienz M", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "15208637", "url": "https://glygen.org/publication/PubMed/15208637" } ] }, { "title": "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.", "journal": "Cell", "date": "2004", "authors": "Lu W, Yamamoto V, Ortega B, Baltimore D", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "15454084", "url": "https://glygen.org/publication/PubMed/15454084" } ] }, { "title": "Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.", "journal": "Development (Cambridge, England)", "date": "2004", "authors": "Cong F, Schweizer L, Varmus H", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "15459103", "url": "https://glygen.org/publication/PubMed/15459103" } ] }, { "title": "Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.", "journal": "Molecular cell", "date": "2005", "authors": "Meulmeester E, Maurice MM, Boutell C, Teunisse AF, Ovaa H, Abraham TE, Dirks RW, Jochemsen AG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "15916963", "url": "https://glygen.org/publication/PubMed/15916963" } ] }, { "title": "NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.", "journal": "The Biochemical journal", "date": "2005", "authors": "Chang W, Dynek JN, Smith S", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "16076287", "url": "https://glygen.org/publication/PubMed/16076287" } ] }, { "title": "Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract.", "journal": "Nature neuroscience", "date": "2005", "authors": "Liu Y, Shi J, Lu CC, Wang ZB, Lyuksyutova AI, Song XJ, Zou Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "16116452", "url": "https://glygen.org/publication/PubMed/16116452" } ] }, { "title": "Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.", "journal": "Cellular signalling", "date": "2006", "authors": "Tzimas C, Michailidou G, Arsenakis M, Kieff E, Mosialos G, Hatzivassiliou EG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "16214042", "url": "https://glygen.org/publication/PubMed/16214042" } ] }, { "title": "Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping.", "journal": "Nature", "date": "2006", "authors": "Schmitt AM, Shi J, Wolf AM, Lu CC, King LA, Zou Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "16280981", "url": "https://glygen.org/publication/PubMed/16280981" } ] }, { "title": "Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.", "journal": "Journal of cell science", "date": "2006", "authors": "Krieghoff E, Behrens J, Mayr B", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "16554443", "url": "https://glygen.org/publication/PubMed/16554443" } ] }, { "title": "The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2006", "authors": "Keeble TR, Halford MM, Seaman C, Kee N, Macheda M, Anderson RB, Stacker SA, Cooper HM", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "16723543", "url": "https://glygen.org/publication/PubMed/16723543" } ] }, { "title": "Tankyrase recruitment to the lateral membrane in polarized epithelial cells: regulation by cell-cell contact and protein poly(ADP-ribosyl)ation.", "journal": "The Biochemical journal", "date": "2006", "authors": "Yeh TY, Meyer TN, Schwesinger C, Tsun ZY, Lee RM, Chi NW", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "16884355", "url": "https://glygen.org/publication/PubMed/16884355" } ] }, { "title": "A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.", "journal": "Cell", "date": "2006", "authors": "Zhang D, Zaugg K, Mak TW, Elledge SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "16901786", "url": "https://glygen.org/publication/PubMed/16901786" } ] }, { "title": "FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.", "journal": "Nature cell biology", "date": "2006", "authors": "van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "16964248", "url": "https://glygen.org/publication/PubMed/16964248" } ] }, { "title": "Ryk: a novel Wnt receptor regulating axon pathfinding.", "journal": "The international journal of biochemistry & cell biology", "date": "2006", "authors": "Keeble TR, Cooper HM", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "16971168", "url": "https://glygen.org/publication/PubMed/16971168" } ] }, { "title": "Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Yeh TY, Sbodio JI, Chi NW", "evidence": [ { "database": "iPTMnet", "id": "O95271", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95271" } ], "reference": [ { "type": "PubMed", "id": "17026964", "url": "https://glygen.org/publication/PubMed/17026964" } ] }, { "title": "NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.", "journal": "Cell", "date": "2007", "authors": "Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "17218260", "url": "https://glygen.org/publication/PubMed/17218260" } ] }, { "title": "An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.", "journal": "Cancer research", "date": "2007", "authors": "Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "17234765", "url": "https://glygen.org/publication/PubMed/17234765" } ] }, { "title": "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.", "journal": "The EMBO journal", "date": "2007", "authors": "Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17290220", "url": "https://glygen.org/publication/PubMed/17290220" } ] }, { "title": "Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.", "journal": "Nature", "date": "2007", "authors": "Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17443180", "url": "https://glygen.org/publication/PubMed/17443180" } ] }, { "title": "Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2007", "authors": "Popov N, Herold S, Llamazares M, Schulein C, Eilers M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17873522", "url": "https://glygen.org/publication/PubMed/17873522" } ] }, { "title": "Human USP3 is a chromatin modifier required for S phase progression and genome stability.", "journal": "Current biology : CB", "date": "2007", "authors": "Nicassio F, Corrado N, Vissers JH, Areces LB, Bergink S, Marteijn JA, Geverts B, Houtsmuller AB, Vermeulen W, Di Fiore PP, Citterio E", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17980597", "url": "https://glygen.org/publication/PubMed/17980597" } ] }, { "title": "Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.", "journal": "Developmental cell", "date": "2007", "authors": "Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "17981138", "url": "https://glygen.org/publication/PubMed/17981138" } ] }, { "title": "Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.", "journal": "Development (Cambridge, England)", "date": "2008", "authors": "Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "18077588", "url": "https://glygen.org/publication/PubMed/18077588" } ] }, { "title": "Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.", "journal": "Genes & development", "date": "2008", "authors": "Nakagawa T, Kajitani T, Togo S, Masuko N, Ohdan H, Hishikawa Y, Koji T, Matsuyama T, Ikura T, Muramatsu M, Ito T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18172164", "url": "https://glygen.org/publication/PubMed/18172164" } ] }, { "title": "Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.", "journal": "Cell", "date": "2008", "authors": "Wu X, Tu X, Joeng KS, Hilton MJ, Williams DA, Long F", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "18423204", "url": "https://glygen.org/publication/PubMed/18423204" } ] }, { "title": "Zinc binding catalytic domain of human tankyrase 1.", "journal": "J. Mol. Biol.", "date": "2008", "authors": "Lehtio L, Collins R, van den Berg S, Johansson A, Dahlgren LG, Hammarstrom M, Helleday T, Holmberg-Schiavone L, Karlberg T, Weigelt J", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "18436240", "url": "https://glygen.org/publication/PubMed/18436240" } ] }, { "title": "Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18467330", "url": "https://glygen.org/publication/PubMed/18467330" } ] }, { "title": "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.", "journal": "American journal of physiology. Renal physiology", "date": "2008", "authors": "Boulkroun S, Ruffieux-Daidie D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18632802", "url": "https://glygen.org/publication/PubMed/18632802" } ] }, { "title": "The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.", "journal": "EMBO reports", "date": "2008", "authors": "Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cardenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "18636086", "url": "https://glygen.org/publication/PubMed/18636086" } ] }, { "title": "Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis.", "journal": "Developmental cell", "date": "2008", "authors": "Lyu J, Yamamoto V, Lu W", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "19000841", "url": "https://glygen.org/publication/PubMed/19000841" } ] }, { "title": "USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Lu Y, Adegoke OA, Nepveu A, Nakayama KI, Bedard N, Cheng D, Peng J, Wing SS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19015242", "url": "https://glygen.org/publication/PubMed/19015242" } ] }, { "title": "Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.", "journal": "Nature chemical biology", "date": "2009", "authors": "Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, Roth MG, Amatruda JF, Chen C, Lum L", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "19125156", "url": "https://glygen.org/publication/PubMed/19125156" } ] }, { "title": "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.", "journal": "Cell", "date": "2009", "authors": "Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19135894", "url": "https://glygen.org/publication/PubMed/19135894" } ] }, { "title": "USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Burrows JF, Kelvin AA, McFarlane C, Burden RE, McGrattan MJ, De la Vega M, Govender U, Quinn DJ, Dib K, Gadina M, Scott CJ, Johnston JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19188362", "url": "https://glygen.org/publication/PubMed/19188362" } ] }, { "title": "Rak functions as a tumor suppressor by regulating PTEN protein stability and function.", "journal": "Cancer cell", "date": "2009", "authors": "Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "19345329", "url": "https://glygen.org/publication/PubMed/19345329" } ] }, { "title": "Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19363159", "url": "https://glygen.org/publication/PubMed/19363159" } ] }, { "title": "The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Bomberger JM, Barnaby RL, Stanton BA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19398555", "url": "https://glygen.org/publication/PubMed/19398555" } ] }, { "title": "The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.", "journal": "The EMBO journal", "date": "2009", "authors": "Berthouze M, Venkataramanan V, Li Y, Shenoy SK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19424180", "url": "https://glygen.org/publication/PubMed/19424180" } ] }, { "title": "X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Van Themsche C, Leblanc V, Parent S, Asselin E", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "19473982", "url": "https://glygen.org/publication/PubMed/19473982" } ] }, { "title": "Wnt/beta-catenin signaling: components, mechanisms, and diseases.", "journal": "Developmental cell", "date": "2009", "authors": "MacDonald BT, Tamai K, He X", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "19619488", "url": "https://glygen.org/publication/PubMed/19619488" } ] }, { "title": "Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "19729658", "url": "https://glygen.org/publication/PubMed/19729658" } ] }, { "title": "Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.", "journal": "Nature", "date": "2009", "authors": "Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "Reactome", "id": "R-HSA-5545619", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5545619" } ], "reference": [ { "type": "PubMed", "id": "19759537", "url": "https://glygen.org/publication/PubMed/19759537" } ] }, { "title": "MdmX is a substrate for the deubiquitinating enzyme USP2a.", "journal": "Oncogene", "date": "2010", "authors": "Allende-Vega N, Sparks A, Lane DP, Saville MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19838211", "url": "https://glygen.org/publication/PubMed/19838211" } ] }, { "title": "USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.", "journal": "Cellular signalling", "date": "2010", "authors": "Sun W, Tan X, Shi Y, Xu G, Mao R, Gu X, Fan Y, Yu Y, Burlingame S, Zhang H, Rednam SP, Lu X, Zhang T, Fu S, Cao G, Qin J, Yang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19874889", "url": "https://glygen.org/publication/PubMed/19874889" } ] }, { "title": "Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "19910467", "url": "https://glygen.org/publication/PubMed/19910467" } ] }, { "title": "Ryks: new partners for Wnts in the developing and regenerating nervous system.", "journal": "Trends in neurosciences", "date": "2010", "authors": "Fradkin LG, Dura JM, Noordermeer JN", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "20004982", "url": "https://glygen.org/publication/PubMed/20004982" } ] }, { "title": "USP10 regulates p53 localization and stability by deubiquitinating p53.", "journal": "Cell", "date": "2010", "authors": "Yuan J, Luo K, Zhang L, Cheville JC, Lou Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20096447", "url": "https://glygen.org/publication/PubMed/20096447" } ] }, { "title": "Toward a unified nomenclature for mammalian ADP-ribosyltransferases.", "journal": "Trends Biochem. Sci.", "date": "2010", "authors": "Hottiger Michael O, Hassa Paul O, L\u00fcscher Bernhard, Sch\u00fcler Herwig, Koch-Nolte Friedrich", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "20106667", "url": "https://glygen.org/publication/PubMed/20106667" } ] }, { "title": "Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.", "journal": "Nature cell biology", "date": "2010", "authors": "Pereg Y, Liu BY, O'Rourke KM, Sagolla M, Dey A, Komuves L, French DM, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20228808", "url": "https://glygen.org/publication/PubMed/20228808" } ] }, { "title": "The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.", "journal": "Cell research", "date": "2010", "authors": "Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20368735", "url": "https://glygen.org/publication/PubMed/20368735" } ] }, { "title": "The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.", "journal": "Molecular cancer research : MCR", "date": "2010", "authors": "Dirac AM, Bernards R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "20501646", "url": "https://glygen.org/publication/PubMed/20501646" } ] }, { "title": "The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2).", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Kim S, Jho EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "20858899", "url": "https://glygen.org/publication/PubMed/20858899" } ] }, { "title": "Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Ramakrishna S, Suresh B, Lee EJ, Lee HJ, Ahn WS, Baek KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21239494", "url": "https://glygen.org/publication/PubMed/21239494" } ] }, { "title": "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta.", "journal": "Molecular cell", "date": "2011", "authors": "Parsons JL, Dianova II, Khoronenkova SV, Edelmann MJ, Kessler BM, Dianov GL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21362556", "url": "https://glygen.org/publication/PubMed/21362556" } ] }, { "title": "The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling.", "journal": "Molecular and cellular biology", "date": "2011", "authors": "Lui TT, Lacroix C, Ahmed SM, Goldenberg SJ, Leach CA, Daulat AM, Angers S", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "21383061", "url": "https://glygen.org/publication/PubMed/21383061" } ] }, { "title": "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.", "journal": "Nature cell biology", "date": "2011", "authors": "Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "21478859", "url": "https://glygen.org/publication/PubMed/21478859" } ] }, { "title": "WWP2 is an E3 ubiquitin ligase for PTEN.", "journal": "Nature cell biology", "date": "2011", "authors": "Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "21532586", "url": "https://glygen.org/publication/PubMed/21532586" } ] }, { "title": "Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Chen M, Gutierrez GJ, Ronai ZA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21571647", "url": "https://glygen.org/publication/PubMed/21571647" } ] }, { "title": "Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.", "journal": "Molecular cell", "date": "2011", "authors": "Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21596315", "url": "https://glygen.org/publication/PubMed/21596315" } ] }, { "title": "USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Scortegagna M, Subtil T, Qi J, Kim H, Zhao W, Gu W, Kluger H, Ronai ZA", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21659512", "url": "https://glygen.org/publication/PubMed/21659512" } ] }, { "title": "Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.", "journal": "PLoS ONE", "date": "2011", "authors": "Callow MG, Tran H, Phu L, Lau T, Lee J, Sandoval WN, Liu PS, Bheddah S, Tao J, Lill JR, Hongo JA, Davis D, Kirkpatrick DS, Polakis P, Costa M", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "21799911", "url": "https://glygen.org/publication/PubMed/21799911" } ] }, { "title": "The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Mei Y, Hahn AA, Hu S, Yang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21849505", "url": "https://glygen.org/publication/PubMed/21849505" } ] }, { "title": "Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/beta-catenin signaling.", "journal": "The Journal of cell biology", "date": "2011", "authors": "Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "21875946", "url": "https://glygen.org/publication/PubMed/21875946" } ] }, { "title": "Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.", "journal": "Cell", "date": "2011", "authors": "Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, Choi A, Ke H, Ma D, Yuan J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "21962518", "url": "https://glygen.org/publication/PubMed/21962518" } ] }, { "title": "Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.", "journal": "Developmental cell", "date": "2011", "authors": "Ahn VE, Chu ML, Choi HJ, Tran D, Abo A, Weis WI", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "22000856", "url": "https://glygen.org/publication/PubMed/22000856" } ] }, { "title": "FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis.", "journal": "Cancer cell", "date": "2011", "authors": "Zhang N, Wei P, Gong A, Chiu WT, Lee HT, Colman H, Huang H, Xue J, Liu M, Wang Y, Sawaya R, Xie K, Yung WK, Medema RH, He X, Huang S", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "22014570", "url": "https://glygen.org/publication/PubMed/22014570" } ] }, { "title": "Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFalpha-induced cancer cell migration.", "journal": "The Biochemical journal", "date": "2012", "authors": "Xiao N, Li H, Luo J, Wang R, Chen H, Chen J, Wang P", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "22029577", "url": "https://glygen.org/publication/PubMed/22029577" } ] }, { "title": "Regulation of p53 stability and function by the deubiquitinating enzyme USP42.", "journal": "The EMBO journal", "date": "2011", "authors": "Hock AK, Vigneron AM, Carter S, Ludwig RL, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "22085928", "url": "https://glygen.org/publication/PubMed/22085928" } ] }, { "title": "Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Altun M, Zhao B, Velasco K, Liu H, Hassink G, Paschke J, Pereira T, Lindsten K", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "22128162", "url": "https://glygen.org/publication/PubMed/22128162" } ] }, { "title": "Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin.", "journal": "PloS one", "date": "2011", "authors": "Zhang YH, Zhou CJ, Zhou ZR, Song AX, Hu HY", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "22216260", "url": "https://glygen.org/publication/PubMed/22216260" } ] }, { "title": "Wnt/beta-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Tauriello DV, Jordens I, Kirchner K, Slootstra JW, Kruitwagen T, Bouwman BA, Noutsou M, Rudiger SG, Schwamborn K, Schambony A, Maurice MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "22411803", "url": "https://glygen.org/publication/PubMed/22411803" } ] }, { "title": "The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Ahmed SF, Deb S, Paul I, Chatterjee A, Mandal T, Chatterjee U, Ghosh MK", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "22427670", "url": "https://glygen.org/publication/PubMed/22427670" } ] }, { "title": "A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.", "journal": "Cancer research", "date": "2012", "authors": "Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "22440753", "url": "https://glygen.org/publication/PubMed/22440753" } ] }, { "title": "Structural basis of Wnt recognition by Frizzled.", "journal": "Science (New York, N.Y.)", "date": "2012", "authors": "Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "22653731", "url": "https://glygen.org/publication/PubMed/22653731" } ] }, { "title": "The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Macheda ML, Sun WW, Kugathasan K, Hogan BM, Bower NI, Halford MM, Zhang YF, Jacques BE, Lieschke GJ, Dabdoub A, Stacker SA", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "22773843", "url": "https://glygen.org/publication/PubMed/22773843" } ] }, { "title": "Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.", "journal": "Molecular cell", "date": "2012", "authors": "Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, Inaba T", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "22864114", "url": "https://glygen.org/publication/PubMed/22864114" } ] }, { "title": "Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.", "journal": "PloS one", "date": "2012", "authors": "Bao R, Christova T, Song S, Angers S, Yan X, Attisano L", "evidence": [ { "database": "Reactome", "id": "R-HSA-4641257", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257" } ], "reference": [ { "type": "PubMed", "id": "23144924", "url": "https://glygen.org/publication/PubMed/23144924" } ] }, { "title": "The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2012", "authors": "Zhang L, Lubin A, Chen H, Sun Z, Gong F", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23159851", "url": "https://glygen.org/publication/PubMed/23159851" } ] }, { "title": "The way Wnt works: components and mechanism.", "journal": "Growth factors (Chur, Switzerland)", "date": "2013", "authors": "Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "23256519", "url": "https://glygen.org/publication/PubMed/23256519" } ] }, { "title": "Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23395819", "url": "https://glygen.org/publication/PubMed/23395819" } ] }, { "title": "RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation.", "journal": "Cell research", "date": "2013", "authors": "Lee JT, Shan J, Zhong J, Li M, Zhou B, Zhou A, Parsons R, Gu W", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "23419514", "url": "https://glygen.org/publication/PubMed/23419514" } ] }, { "title": "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.", "journal": "Nature", "date": "2013", "authors": "Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23486064", "url": "https://glygen.org/publication/PubMed/23486064" } ] }, { "title": "Proteasome regulation by ADP-ribosylation.", "journal": "Cell", "date": "2013", "authors": "Cho-Park PF, Steller H", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "23622245", "url": "https://glygen.org/publication/PubMed/23622245" } ] }, { "title": "structural Studies of Wnts and identification of an LRP6 binding site.", "journal": "Structure (London, England : 1993)", "date": "2013", "authors": "Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "23791946", "url": "https://glygen.org/publication/PubMed/23791946" } ] }, { "title": "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.", "journal": "Genes & development", "date": "2013", "authors": "Zhang Z, Jones A, Joo HY, Zhou D, Cao Y, Chen S, Erdjument-Bromage H, Renfrow M, He H, Tempst P, Townes TM, Giles KE, Ma L, Wang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23824326", "url": "https://glygen.org/publication/PubMed/23824326" } ] }, { "title": "USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.", "journal": "The Journal of experimental medicine", "date": "2013", "authors": "Liu X, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X, Dong C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "23825189", "url": "https://glygen.org/publication/PubMed/23825189" } ] }, { "title": "Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24056413", "url": "https://glygen.org/publication/PubMed/24056413" } ] }, { "title": "Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling.", "journal": "PloS one", "date": "2013", "authors": "Zhong H, Wang D, Fang L, Zhang H, Luo R, Shang M, Ouyang C, Ouyang H, Chen H, Xiao S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24260525", "url": "https://glygen.org/publication/PubMed/24260525" } ] }, { "title": "Deubiquitylation and stabilization of PTEN by USP13.", "journal": "Nature cell biology", "date": "2013", "authors": "Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "24270891", "url": "https://glygen.org/publication/PubMed/24270891" } ] }, { "title": "Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014", "authors": "Hodakoski C, Hopkins BD, Barrows D, Mense SM, Keniry M, Anderson KE, Kern PA, Hawkins PT, Stephens LR, Parsons R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "24367090", "url": "https://glygen.org/publication/PubMed/24367090" } ] }, { "title": "USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.", "journal": "The Journal of experimental medicine", "date": "2014", "authors": "Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, Zhang H, An L, Zhao Y, Xu X, Chen Z, Kogiso M, Zhang D, Zhang H, Zhang P, Jung JU, Li X, Xu G, Yang J", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24493797", "url": "https://glygen.org/publication/PubMed/24493797" } ] }, { "title": "The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy.", "journal": "Nature", "date": "2014", "authors": "Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "24896179", "url": "https://glygen.org/publication/PubMed/24896179" } ] }, { "title": "Family-wide analysis of poly(ADP-ribose) polymerase activity.", "journal": "Nature communications", "date": "2014", "authors": "Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I, Chang P", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "25043379", "url": "https://glygen.org/publication/PubMed/25043379" } ] }, { "title": "Deubiquitination and stabilization of IL-33 by USP21.", "journal": "International journal of clinical and experimental pathology", "date": "2014", "authors": "Tao L, Chen C, Song H, Piccioni M, Shi G, Li B", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "25197364", "url": "https://glygen.org/publication/PubMed/25197364" } ] }, { "title": "The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Zhang Z, Yang H, Wang H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "25305019", "url": "https://glygen.org/publication/PubMed/25305019" } ] }, { "title": "Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.", "journal": "Genes & development", "date": "2015", "authors": "Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "25547115", "url": "https://glygen.org/publication/PubMed/25547115" } ] }, { "title": "The deubiquitinating enzyme USP24 is a regulator of the UV damage response.", "journal": "Cell reports", "date": "2015", "authors": "Zhang L, Nemzow L, Chen H, Lubin A, Rong X, Sun Z, Harris TK, Gong F", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "25578727", "url": "https://glygen.org/publication/PubMed/25578727" } ] }, { "title": "PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.", "journal": "Nature communications", "date": "2015", "authors": "Lee MS, Jeong MH, Lee HW, Han HJ, Ko A, Hewitt SM, Kim JH, Chun KH, Chung JY, Lee C, Cho H, Song J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "26183061", "url": "https://glygen.org/publication/PubMed/26183061" } ] }, { "title": "Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.", "journal": "Nature cell biology", "date": "2015", "authors": "Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, Zhou T, Gao D, Xiao ZX, Yin Y, Wei W, He F, Zhang L", "evidence": [ { "database": "Reactome", "id": "R-HSA-8948751", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751" } ], "reference": [ { "type": "PubMed", "id": "26280536", "url": "https://glygen.org/publication/PubMed/26280536" } ] }, { "title": "Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.", "journal": "J. Biol. Chem.", "date": "2021", "authors": "Ryan K, Bolanos B, Smith M, Palde PB, Cuenca PD, VanArsdale TL, Niessen S, Zhang L, Behenna D, Ornelas MA, Tran KT, Kaiser S, Lum L, Stewart A, Gajiwala KS", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "33361107", "url": "https://glygen.org/publication/PubMed/33361107" } ] }, { "title": "Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner.", "journal": "Communications biology", "date": "2021", "authors": "Yue X, Tiwari N, Zhu L, Ngo HDT, Lim JM, Gim B, Jing S, Wang Y, Qian Y, Lee I", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" } ], "reference": [ { "type": "PubMed", "id": "34876695", "url": "https://glygen.org/publication/PubMed/34876695" } ] }, { "title": "Deubiquitination of TNKS1 Regulates Wnt/beta-Catenin to Affect the Expression of USP25 to Promote the Progression of Glioma.", "journal": "Disease markers", "date": "2022", "authors": "Tang B, Luo H, Xie S, Pan C, Fu J", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" } ], "reference": [ { "type": "PubMed", "id": "35450028", "url": "https://glygen.org/publication/PubMed/35450028" } ] }, { "title": "Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2022", "authors": "Xu YR, Shi ML, Zhang Y, Kong N, Wang C, Xiao YF, Du SS, Zhu QY, Lei CQ", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" } ], "reference": [ { "type": "PubMed", "id": "35733260", "url": "https://glygen.org/publication/PubMed/35733260" } ] }, { "title": "Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers.", "journal": "Ecotoxicology and environmental safety", "date": "2023-01-15", "authors": "Duan Xiaoran, Huang Tao, Zhang Daping, Wei Yujie, Li Lifeng, Yao Wu, Cui Liuxin, Zhou Xiaoshan, Yang Yongli, Wang Wei, Zhao Jie", "evidence": [ { "database": "RefSeq", "id": "NP_003738", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003738" } ], "reference": [ { "type": "PubMed", "id": "36603485", "url": "https://glygen.org/publication/PubMed/36603485" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95271", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95271" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T.", "journal": "Biochemistry", "date": "1995", "authors": "Wilkinson KD, Tashayev VL, O'Connor LB, Larsen CN, Kasperek E, Pickart CM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880" } ], "reference": [ { "type": "PubMed", "id": "7578059", "url": "https://glygen.org/publication/PubMed/7578059" } ] }, { "title": "Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.", "journal": "The EMBO journal", "date": "1997", "authors": "Kutay U, Izaurralde E, Bischoff FR, Mattaj IW, Gorlich D", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "9135132", "url": "https://glygen.org/publication/PubMed/9135132" } ] }, { "title": "Evolutionary specialization of the nuclear targeting apparatus.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Malik HS, Eickbush TH, Goldfarb DS", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "9391096", "url": "https://glygen.org/publication/PubMed/9391096" } ] }, { "title": "Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin.", "journal": "Current biology : CB", "date": "1998", "authors": "Fagotto F, Gluck U, Gumbiner BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-201681", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681" } ], "reference": [ { "type": "PubMed", "id": "9501980", "url": "https://glygen.org/publication/PubMed/9501980" } ] }, { "title": "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.", "journal": "Science", "date": "1998", "authors": "Smith S, Giriat I, Schmitt A, de Lange T", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "reference": [ { "type": "PubMed", "id": "9822378", "url": "https://glygen.org/publication/PubMed/9822378" } ] } ], "pathway": [ { "id": "hsa:8658", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8658", "resource": "KEGG Pathway" }, { "id": "R-HSA-201681", "name": "TCF dependent signaling in response to WNT", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-201681", "resource": "Reactome", "description": "TCF dependent signaling in response to WNT" }, { "id": "R-HSA-4641257", "name": "Degradation of AXIN", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4641257", "resource": "Reactome", "description": "Degradation of AXIN" }, { "id": "R-HSA-5545619", "name": "XAV939 stabilizes AXIN", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5545619", "resource": "Reactome", "description": "XAV939 stabilizes AXIN" }, { "id": "R-HSA-5689880", "name": "Ub-specific processing proteases", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-HSA-8948751", "name": "Regulation of PTEN stability and activity", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948751", "resource": "Reactome", "description": "Regulation of PTEN stability and activity" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z8Q6-1", "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "Tnks", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAATAAAPAASAAVGVAPSPAGGGGNNSASSTSSPTSSSSSSPSSPGSSIAESPEAAGVGSTATLGPGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLERGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYVCHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1317 }, "evidence": [ { "id": "45929413", "url": "http://www.informatics.jax.org/homology/45929413", "database": "MGI" }, { "id": "O95271", "url": "https://omabrowser.org/oma/group/O95271/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q6PFX9-1", "protein_name": "Poly [ADP-ribose] polymerase tankyrase-1", "gene_name": "Tnks", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGPTPASPTAGGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGAVCTVAAPAAVPAASAAVGVAPTPAGGGGGGGNNSASSASSPTSSSSSSPSSPGSSLAESPEAAGVGSTATLGAGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPMRTSDVDYRLLEASKAGDLETVKQLCSPQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLTDLAVGGASNAGDGAAGAERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT", "length": 1320 }, "evidence": [ { "id": "45929413", "url": "http://www.informatics.jax.org/homology/45929413", "database": "MGI" }, { "id": "O95271", "url": "https://omabrowser.org/oma/group/O95271/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VBP3-1", "protein_name": "Poly [ADP-ribose] polymerase tankyrase", "gene_name": "Tnks", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MANSSRSRAILSVNLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLHRCARDEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMATSLSQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQIVKPDDSSSGTEDTR", "length": 1181 }, "evidence": [ { "id": "O95271", "url": "https://omabrowser.org/oma/group/O95271/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "NAD+ ADP-ribosyltransferase activity", "id": "GO:0003950", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003950", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "NAD+-protein ADP-ribosyltransferase activity", "id": "GO:1990404", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990404", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "histone binding", "id": "GO:0042393", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042393", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "nucleotidyltransferase activity", "id": "GO:0016779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016779", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "nuclear body", "id": "GO:0016604", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "nuclear pore", "id": "GO:0005643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005643", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "mitotic spindle pole", "id": "GO:0097431", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "pericentriolar material", "id": "GO:0000242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000242", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "chromosome, telomeric region", "id": "GO:0000781", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 21, "go_terms": [ { "name": "protein auto-ADP-ribosylation", "id": "GO:0070213", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070213", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "protein transport", "id": "GO:0015031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "positive regulation of telomere maintenance via telomerase", "id": "GO:0032212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032212", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "positive regulation of telomerase activity", "id": "GO:0051973", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051973", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "protein localization to chromosome, telomeric region", "id": "GO:0070198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070198", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "Wnt signaling pathway", "id": "GO:0016055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "peptidyl-threonine phosphorylation", "id": "GO:0018107", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018107", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "positive regulation of canonical Wnt signaling pathway", "id": "GO:0090263", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "peptidyl-serine phosphorylation", "id": "GO:0018105", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018105", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "spindle assembly", "id": "GO:0051225", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "regulation of telomere maintenance via telomerase", "id": "GO:0032210", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032210", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "mRNA transport", "id": "GO:0051028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051028", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "positive regulation of telomere capping", "id": "GO:1904355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904355", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric", "id": "GO:1904908", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904908", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "protein poly-ADP-ribosylation", "id": "GO:0070212", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070212", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "negative regulation of telomeric DNA binding", "id": "GO:1904743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904743", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" }, { "name": "negative regulation of telomere maintenance via telomere lengthening", "id": "GO:1904357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904357", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1030, "end_pos": 1032, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1217, "end_pos": 1219, "annotation": "n_glycosylation_sequon" }, { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 837, "end_pos": 839, "annotation": "n_glycosylation_sequon" }, { "start_pos": 897, "end_pos": 899, "annotation": "n_glycosylation_sequon" }, { "start_pos": 994, "end_pos": 996, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "PubMed", "id": "21478859", "url": "https://glygen.org/publication/PubMed/21478859" } ] }, { "annotation": "Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis.", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "PubMed", "id": "10988299", "url": "https://glygen.org/publication/PubMed/10988299" } ] }, { "annotation": "Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation.", "evidence": [ { "database": "UniProtKB", "id": "O95271", "url": "https://www.uniprot.org/uniprot/O95271" }, { "database": "PubMed", "id": "21478859", "url": "https://glygen.org/publication/PubMed/21478859" } ] } ], "interactions": [], "reactions": [ { "id": "54424", "name": "", "equation": "L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5U2Q4-1", "P27008-1", "Q2NL67-1", "Q53GL7-1", "Q8N5Y8-1", "Q7Z3E1-1", "P09874-1", "Q9UGN5-1", "Q460N3-1", "Q9UKK3-1", "Q9H0J9-1", "Q9NR21-4", "Q9Y6F1-1", "O95271-1", "Q9H2K2-1", "Q8CIE4-1", "Q8C1B2-1", "Q8CFF0-1", "Q8BZ20-1", "Q6P6P7-1", "O88554-1", "P11103-1", "Q7TMM8-1", "Q3UES3-1", "Q6PFX9-1", "E9PYK3-1", "Q3ULW8-1", "Q54YW4-1", "P35875-1", "Q9VBP3-1", "A1ZAG4-1" ], "evidence": [ { "id": "54424", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/54424" } ] }, { "id": "58224", "name": "", "equation": "L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5U2Q4-1", "P27008-1", "Q53GL7-1", "Q8N5Y8-1", "Q7Z3E1-1", "P09874-1", "Q9UGN5-1", "Q460N3-1", "Q460N5-6", "Q9UKK3-1", "Q9NR21-4", "Q9Y6F1-1", "O95271-1", "Q9H2K2-1", "Q8CIE4-1", "Q8C1B2-1", "Q8CFF0-1", "O88554-1", "P11103-1", "Q2EMV9-1", "Q7TMM8-1", "Q3UES3-1", "Q6PFX9-1", "E9PYK3-1", "Q3ULW8-1", "Q54YW4-1", "P35875-1", "Q9VBP3-1", "A1ZAG4-1" ], "evidence": [ { "id": "58224", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/58224" } ] }, { "id": "R-HSA-3640844", "name": "RNF146 binds RibC-AXIN:TNKS complex", "equation": "", "summary": "RNF146 is an E3 RING ubiquitin ligase that was identified as a positive regulator of WNT signalling (Callow et al, 2011; Zhang et al, 2011). Depletion of RNF146 increases the levels of AXIN and decreases expression of WNT target genes and WNT-responsive reporters in a WNT-independent manner (Zhang et al, 2011; Callow et al, 2011). RNF146 binds directly to poly-ADP-ribose groups through its WWE domain and ubiquitinates substrates in a tankyrase-dependent manner (Zhang et al, 2011). AXIN, Tankyrase and RNF146 are thought to exist in a complex (Callow et al, 2011) and RNF146 mediates the tankyrase-dependent ubiquitination of all three proteins to promote their degradation (Callow et al, 2011; Zhang et al, 2011). In this reaction, only the targeted degradation of AXIN is depicted.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95271-1", "Q9NTX7-1", "Q9H2K2-1" ], "evidence": [ { "id": "R-HSA-3640844", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3640844" } ] }, { "id": "R-HSA-3640858", "name": "Tankyrase ADP-ribosylates AXIN", "equation": "", "summary": "TNKS1 and 2 function redundantly to control AXIN protein levels through the addition of poly-ADP-ribosyl groups (PARSylation), which may lead to subsequent ubiquitination and degradation by the proteasome. In HEK293, SW480 and breast cancer cell lines, depletion of TNKS1 and 2 increases the protein levels of AXIN1 and AXIN2 resulting in increased beta-catenin phosphorylation, decreased beta-catenin abundance and decreased expression of WNT targets and WNT-responsive reporters (Huang et al, 2009; Callow et al, 2011; Waaler et al, 2012; Bao et al, 2012). In vitro, TNKS2 catalyzes the addition of ADP-ribosyl groups to the TBD fragment of AXIN1, while in vivo, both exogenous GST-AXIN1 and endogenous AXIN1 are PARSylated in a TNKS-dependent manner (Huang et al, 2009; Callow et al, 2011; Zhang et al, 2011). PARSylation is likely required for the subsequent proteasome-mediated degradation of AXIN, as the increase in levels of polyubiquitinated AXIN1 and 2 seen upon treatment of cells with the proteasome inhibitor MG132 is lost if cells are simultaneously treated with an inhibitor of TNKS1 and 2 (Huang et al, 2009). Although in this reaction, TNKS is shown PARSylating unbound AXIN, it is likely that this regulation occurs at the level of the destruction complex. Also not shown in this reaction is the ability of TNKS to catalyze autoPARSylation reactions, which ultimately lead to its own degradation (Yeh et al, 2006; Huang et al, 2009; Zhang et al, 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95271-1", "Q9H2K2-1" ], "evidence": [ { "id": "R-HSA-3640858", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3640858" } ] }, { "id": "R-HSA-3640861", "name": "RNF146 ubiquitinates ADP-ribosylated AXIN", "equation": "", "summary": "RNF146 has in vitro and in vivo ubiquitination activity against AXIN, Tankyrase and itself (Callow et al, 2011; Zhang et al, 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95271-1", "Q9NTX7-1", "Q9H2K2-1" ], "evidence": [ { "id": "R-HSA-3640861", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3640861" } ] }, { "id": "R-HSA-3640862", "name": "Tankyrase binds AXIN", "equation": "", "summary": "Several recent chemical screens have identified inhibitors of the poly-ADP ribosylation enzymes tankyrase (TNKS) 1 and 2 as regulators of WNT signalling (Huang et al, 2009; Chen et al, 2009; Waaler et al, 2012). Endogenous TNKS1 and 2 associate with AXIN2 in SW480 cells as assessed by co-immunoprecipitation. Both AXIN1 and AXIN2 interact strongly with TNKS1/2 by two-hybrid, and deletion analysis shows that amino acids 19-30 of AXIN1 are necessary and sufficient for binding to TNKS1. This region, termed the tankyrase-binding-domain (TBD) is necessary and sufficient for the interaction in GST-pulldown and co-immunoprecipitation studies (Huang et al, 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95271-1", "Q9H2K2-1" ], "evidence": [ { "id": "R-HSA-3640862", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3640862" } ] }, { "id": "R-HSA-3640872", "name": "USP34 deubiquitinates AXIN1,AXIN2", "equation": "", "summary": "UBP34 (also known as USP34) is a ubiquitin protease that co-precipitates in AXIN-containing complexes. In vitro studies show that the core domain of UBP34 is able to deubiquitinate AXIN purified from HEK293 transfected cells, and knockdown of UBP34 reduces AXIN1 protein levels in vivo. Treatment of UBP34-knockdown cells with the tankyrase inhibitor XAV939 reverses the degradation of AXIN, suggesting that the activity of UBP34 counteracts the tankyrase-dependent ubiquitination and degradation of AXIN. UBP34 plays a not-fully characterized role in the nuclear accumulation of AXIN, where AXIN is thought to positively regulate beta-catenin mediated transcription (Lui et al, 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95271-1", "Q9NTX7-1", "Q9H2K2-1", "Q70CQ2-1" ], "evidence": [ { "id": "R-HSA-3640872", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3640872" } ] }, { "id": "R-HSA-3640874", "name": "Ub-RibC-AXIN is degraded by the proteasome", "equation": "", "summary": "In the presence of the proteasome inhibitor MG132, polyubiquitinated forms of AXIN accumulate (Huang et al, 2009; Zhang et al, 2011; Callow et al, 2011). This effect is abrogated by co-treatment of cells with both MG132 and inhibitors of tankyrase activity, suggesting that both PARSylation and ubiquitination are required for AXIN degradation (Huang et al, 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A5LHX3-1", "O95271-1", "O00487-1", "Q9NTX7-1", "P28074-1", "Q99436-1", "Q9H2K2-1", "P28072-1", "P40306-1", "P28065-1", "P28062-1" ], "evidence": [ { "id": "R-HSA-3640874", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3640874" } ] }, { "id": "R-HSA-5262606", "name": "XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling", "equation": "", "summary": "XAV939 binds to the catalytic sites of tankyrase 1 and 2 and inhibits the ADP-ribosylation of AXIN1 and 2. Treatment of cells with XAV939 significantly increases the protein, but not the mRNA levels of AXIN1 and 2 and supports a strong increase in the level of GSK3beta-AXIN complexes. These cells also show increased phosphorylation of beta-catenin, decreased beta-catenin protein levels and a corresponding decrease in beta-catenin dependent transcription. Treatment of DLD-1 cells with XAV939 has also been shown to inhibit proliferation (Huang et al, 2009). XAV939 has not been tested in a clinical setting.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O95271-1", "Q9H2K2-1" ], "evidence": [ { "id": "R-HSA-5262606", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5262606" } ] }, { "id": "R-HSA-8948800", "name": "TNKS and TNKS2 PARylate PTEN", "equation": "", "summary": "PTEN can bind tankyrases TNKS (TNKS1) and TNKS2. The interaction involves the tankyrase binding motif at the N-terminus of PTEN (RYQEDG). TNKS and TNKS2 poly-ADP-ribosylate (PARylate) PTEN on glutamic acid residues E40 and E150 and on aspartic acid residue D326. PTEN PARylation is a pre-requisite for RNF146-mediated ubiquitination of PTEN (Li et al. 2015).", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-199420" ], "output_participant_list": [ "R-HSA-8948798" ], "enzyme_list": [ "O95271-1", "Q9H2K2-1", "P60484-1" ], "evidence": [ { "id": "R-HSA-8948800", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8948800" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-199420", "participant_name": "PTEN [cytosol]", "crossref": [ { "id": "P60484", "database": "UniProt", "url": "" }, { "id": "P60484", "database": "GeneCards", "url": "" }, { "id": "NP_000305.3", "database": "RefSeq", "url": "" }, { "id": "P60484", "database": "PRO", "url": "" }, { "id": "15166", "database": "Orphanet", "url": "" }, { "id": "HMDBP01570", "database": "HMDB Protein", "url": "" }, { "id": "NP_001291646.2", "database": "RefSeq", "url": "" }, { "id": "7JUL", "database": "PDB", "url": "" }, { "id": "7JUK", "database": "PDB", "url": "" }, { "id": "5BZX", "database": "PDB", "url": "" }, { "id": "ENSG00000171862", "database": "OpenTargets", "url": "" }, { "id": "3.1.3.48", "database": "IntEnz", "url": "" }, { "id": "7JTX", "database": "PDB", "url": "" }, { "id": "5BZZ", "database": "PDB", "url": "" }, { "id": "4O1V", "database": "PDB", "url": "" }, { "id": "1D5R", "database": "PDB", "url": "" }, { "id": "2KYL", "database": "PDB", "url": "" }, { "id": "2497", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "ENSG00000171862", "database": "Ensembl", "url": "" }, { "id": "ENST00000688308", "database": "Ensembl", "url": "" }, { "id": "5BUG", "database": "PDB", "url": "" }, { "id": "ENSG00000171862-PTEN", "database": "HPA", "url": "" }, { "id": "NP_001291647.1", "database": "RefSeq", "url": "" }, { "id": "ENST00000371953", "database": "Ensembl", "url": "" }, { "id": "ENSP00000361021", "database": "Ensembl", "url": "" }, { "id": "ENSP00000508752", "database": "Ensembl", "url": "" }, { "id": "7JVX", "database": "PDB", "url": "" }, { "id": "P60484", "database": "ZINC target", "url": "" }, { "id": "7PC7", "database": "PDB", "url": "" }, { "id": "P60484", "database": "Pharos - Targets", "url": "" } ] }, { "participant_id": "R-HSA-8948798", "participant_name": "RibC-E40,E150,D326-PTEN [cytosol]", "crossref": [ { "id": "4O1V", "database": "PDB", "url": "" }, { "id": "NP_001291646.2", "database": "RefSeq", "url": "" }, { "id": "NP_001291647.1", "database": "RefSeq", "url": "" }, { "id": "NP_000305.3", "database": "RefSeq", "url": "" }, { "id": "ENSG00000171862", "database": "Ensembl", "url": "" }, { "id": "7JVX", "database": "PDB", "url": "" }, { "id": "ENSG00000171862", "database": "OpenTargets", "url": "" }, { "id": "7PC7", "database": "PDB", "url": "" }, { "id": "7JTX", "database": "PDB", "url": "" }, { "id": "15166", "database": "Orphanet", "url": "" }, { "id": "5BUG", "database": "PDB", "url": "" }, { "id": "P60484", "database": "UniProt", "url": "" }, { "id": "2KYL", "database": "PDB", "url": "" }, { "id": "ENSP00000361021", "database": "Ensembl", "url": "" }, { "id": "7JUK", "database": "PDB", "url": "" }, { "id": "P60484", "database": "Pharos - Targets", "url": "" }, { "id": "2497", "database": "Guide to Pharmacology - Targets", "url": "" }, { "id": "5BZX", "database": "PDB", "url": "" }, { "id": "ENSP00000508752", "database": "Ensembl", "url": "" }, { "id": "HMDBP01570", "database": "HMDB Protein", "url": "" }, { "id": "ENSG00000171862-PTEN", "database": "HPA", "url": "" }, { "id": "5BZZ", "database": "PDB", "url": "" }, { "id": "P60484", "database": "GeneCards", "url": "" }, { "id": "1D5R", "database": "PDB", "url": "" }, { "id": "ENST00000371953", "database": "Ensembl", "url": "" }, { "id": "7JUL", "database": "PDB", "url": "" }, { "id": "P60484", "database": "ZINC target", "url": "" }, { "id": "3.1.3.48", "database": "IntEnz", "url": "" }, { "id": "P60484", "database": "PRO", "url": "" }, { "id": "ENST00000688308", "database": "Ensembl", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A1ZAG4", "gene_name": "Parp16", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "A1ZAG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAG4" } ] } ] }, { "uniprot_ac": "A5LHX3", "gene_name": "PSMB11", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "A5LHX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A5LHX3" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "A5LHX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A5LHX3" } ] } ] }, { "uniprot_ac": "E9PYK3", "gene_name": "Parp4", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "E9PYK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PYK3" } ] } ] }, { "uniprot_ac": "O00487", "gene_name": "PSMD14", "activity": [ { "ec_number": "3.4.19.-", "activity": "", "evidence": [ { "id": "O00487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00487" } ] } ] }, { "uniprot_ac": "O88554", "gene_name": "Parp2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "O88554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88554" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "O88554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88554" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "O88554", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88554" } ] } ] }, { "uniprot_ac": "O95271", "gene_name": "TNKS", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "O95271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95271" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "O95271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95271" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "O95271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95271" } ] } ] }, { "uniprot_ac": "P09874", "gene_name": "PARP1", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P09874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09874" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P09874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09874" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P09874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09874" } ] } ] }, { "uniprot_ac": "P11103", "gene_name": "Parp1", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P11103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11103" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P11103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11103" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P11103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11103" } ] } ] }, { "uniprot_ac": "P27008", "gene_name": "Parp1", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P27008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27008" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P27008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27008" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P27008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27008" } ] } ] }, { "uniprot_ac": "P28062", "gene_name": "PSMB8", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28062" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28062" } ] } ] }, { "uniprot_ac": "P28065", "gene_name": "PSMB9", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28065" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28065" } ] } ] }, { "uniprot_ac": "P28072", "gene_name": "PSMB6", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28072" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28072" } ] } ] }, { "uniprot_ac": "P28074", "gene_name": "PSMB5", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P28074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28074" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P28074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28074" } ] } ] }, { "uniprot_ac": "P35875", "gene_name": "Parp", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P35875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35875" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P35875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35875" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P35875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35875" } ] } ] }, { "uniprot_ac": "P40306", "gene_name": "PSMB10", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "P40306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40306" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "P40306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40306" } ] } ] }, { "uniprot_ac": "P60484", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] } ] }, { "uniprot_ac": "Q2EMV9", "gene_name": "Parp14", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q2EMV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2EMV9" } ] } ] }, { "uniprot_ac": "Q2NL67", "gene_name": "PARP6", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q2NL67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2NL67" } ] } ] }, { "uniprot_ac": "Q3UES3", "gene_name": "Tnks2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q3UES3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UES3" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "Q3UES3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UES3" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "Q3UES3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UES3" } ] } ] }, { "uniprot_ac": "Q3ULW8", "gene_name": "Parp3", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q3ULW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3ULW8" } ] } ] }, { "uniprot_ac": "Q460N3", "gene_name": "PARP15", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q460N3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q460N3" } ] } ] }, { "uniprot_ac": "Q460N5", "gene_name": "PARP14", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q460N5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q460N5" } ] } ] }, { "uniprot_ac": "Q53GL7", "gene_name": "PARP10", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q53GL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GL7" } ] } ] }, { "uniprot_ac": "Q54YW4", "gene_name": "", "activity": [ { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "Q54YW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54YW4" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "Q54YW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54YW4" } ] } ] }, { "uniprot_ac": "Q5U2Q4", "gene_name": "Parp16", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q5U2Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2Q4" } ] } ] }, { "uniprot_ac": "Q6P6P7", "gene_name": "Parp6", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q6P6P7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6P7" } ] } ] }, { "uniprot_ac": "Q6PFX9", "gene_name": "Tnks", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q6PFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFX9" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "Q6PFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFX9" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "Q6PFX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFX9" } ] } ] }, { "uniprot_ac": "Q70CQ2", "gene_name": "USP34", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q70CQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q70CQ2" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q70CQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q70CQ2" } ] } ] }, { "uniprot_ac": "Q7TMM8", "gene_name": "Parp16", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q7TMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMM8" } ] } ] }, { "uniprot_ac": "Q7Z3E1", "gene_name": "TIPARP", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q7Z3E1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3E1" } ] } ] }, { "uniprot_ac": "Q8BZ20", "gene_name": "Parp12", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8BZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZ20" } ] } ] }, { "uniprot_ac": "Q8C1B2", "gene_name": "Tiparp", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8C1B2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C1B2" } ] } ] }, { "uniprot_ac": "Q8CFF0", "gene_name": "Parp11", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8CFF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFF0" } ] } ] }, { "uniprot_ac": "Q8CIE4", "gene_name": "Parp10", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8CIE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CIE4" } ] } ] }, { "uniprot_ac": "Q8N5Y8", "gene_name": "PARP16", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q8N5Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N5Y8" } ] } ] }, { "uniprot_ac": "Q99436", "gene_name": "PSMB7", "activity": [ { "ec_number": "3.4.25.1", "activity": "Cleavage of peptide bonds with very broad specificity.", "evidence": [ { "id": "Q99436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99436" } ] }, { "ec_number": "3.4.25.1", "activity": "", "evidence": [ { "id": "Q99436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99436" } ] } ] }, { "uniprot_ac": "Q9H0J9", "gene_name": "PARP12", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9H0J9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0J9" } ] } ] }, { "uniprot_ac": "Q9H2K2", "gene_name": "TNKS2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9H2K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2K2" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "Q9H2K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2K2" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "Q9H2K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H2K2" } ] } ] }, { "uniprot_ac": "Q9NR21", "gene_name": "PARP11", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9NR21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NR21" } ] } ] }, { "uniprot_ac": "Q9NTX7", "gene_name": "RNF146", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NTX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NTX7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NTX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NTX7" } ] } ] }, { "uniprot_ac": "Q9UGN5", "gene_name": "PARP2", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9UGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UGN5" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "Q9UGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UGN5" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "Q9UGN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UGN5" } ] } ] }, { "uniprot_ac": "Q9UKK3", "gene_name": "PARP4", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9UKK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UKK3" } ] } ] }, { "uniprot_ac": "Q9VBP3", "gene_name": "Tnks", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9VBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBP3" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "Q9VBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBP3" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "Q9VBP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBP3" } ] } ] }, { "uniprot_ac": "Q9Y6F1", "gene_name": "PARP3", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "Q9Y6F1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y6F1" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 978, 982, 987, 991 ], "sequon_annotation_sites": [ { "start_pos": 1030, "end_pos": 1032 }, { "start_pos": 1217, "end_pos": 1219 }, { "start_pos": 126, "end_pos": 128 }, { "start_pos": 282, "end_pos": 284 }, { "start_pos": 837, "end_pos": 839 }, { "start_pos": 897, "end_pos": 899 }, { "start_pos": 994, "end_pos": 996 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 135 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }