{ "uniprot_canonical_ac": "O95260-1", "uniprot_ac": "O95260", "uniprot_id": "ATE1_HUMAN", "mass": { "chemical_mass": 59090.0, "monoisotopic_mass": 59090.0 }, "refseq": { "ac": "NP_001001976", "name": "arginyl-tRNA--protein transferase 1 isoform 1", "summary": "This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, "gene_names": [ { "name": "ATE1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95260", "id": "O95260" }, { "name": "ATE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976", "id": "NP_001001976" } ], "protein_names": [ { "name": "Arginyl-tRNA--protein transferase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95260" }, { "name": "2.3.2.8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95260" }, { "name": "Arginine-tRNA--protein transferase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95260" }, { "name": "Arginyltransferase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95260" }, { "name": "R-transferase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95260" }, { "name": "arginyl-tRNA--protein transferase 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976", "id": "NP_001001976" }, { "name": "arginyl-tRNA-protein transferase; R-transferase 1; arginine-tRNA--protein transferase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976", "id": "NP_001001976" } ], "function": [ { "annotation": "ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/beta-Catenin Signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, { "database": "PubMed", "id": "34158395", "url": "https://glygen.org/publication/PubMed/34158395" } ] }, { "annotation": "Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, { "database": "PubMed", "id": "34565409", "url": "https://glygen.org/publication/PubMed/34565409" } ] }, { "annotation": "Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.", "evidence": [ { "database": "UniProtKB", "id": "A0A8I5KXU0", "url": "https://www.uniprot.org/uniprot/A0A8I5KXU0#function" }, { "database": "UniProtKB", "id": "PIRNR037207", "url": "https://www.uniprot.org/uniprot/PIRNR037207#function" }, { "database": "UniProtKB", "id": "A0A8I5KVR2", "url": "https://www.uniprot.org/uniprot/A0A8I5KVR2#function" }, { "database": "UniProtKB", "id": "A0A8I5KQ75", "url": "https://www.uniprot.org/uniprot/A0A8I5KQ75#function" }, { "database": "UniProtKB", "id": "A0A8I5KWF1", "url": "https://www.uniprot.org/uniprot/A0A8I5KWF1#function" }, { "database": "UniProtKB", "id": "A0A8I5KX91", "url": "https://www.uniprot.org/uniprot/A0A8I5KX91#function" }, { "database": "UniProtKB", "id": "A0A8I5KNV5", "url": "https://www.uniprot.org/uniprot/A0A8I5KNV5#function" }, { "database": "UniProtKB", "id": "A0A8I5QKV3", "url": "https://www.uniprot.org/uniprot/A0A8I5QKV3#function" }, { "database": "UniProtKB", "id": "A0A8I5KS65", "url": "https://www.uniprot.org/uniprot/A0A8I5KS65#function" }, { "database": "UniProtKB", "id": "A0A8I5KNT9", "url": "https://www.uniprot.org/uniprot/A0A8I5KNT9#function" }, { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260#function" }, { "database": "UniProtKB", "id": "Q9Z2A5", "url": "https://www.uniprot.org/uniprot/Q9Z2A5#function" }, { "database": "UniProtKB", "id": "F8WAC9", "url": "https://www.uniprot.org/uniprot/F8WAC9#function" }, { "database": "UniProtKB", "id": "A0A8I5KYL1", "url": "https://www.uniprot.org/uniprot/A0A8I5KYL1#function" }, { "database": "UniProtKB", "id": "F5GXE4", "url": "https://www.uniprot.org/uniprot/F5GXE4#function" }, { "database": "UniProtKB", "id": "A0A8I5KT53", "url": "https://www.uniprot.org/uniprot/A0A8I5KT53#function" }, { "database": "UniProtKB", "id": "A0A8I5KXF6", "url": "https://www.uniprot.org/uniprot/A0A8I5KXF6#function" }, { "database": "UniProtKB", "id": "A0A8I5KTH0", "url": "https://www.uniprot.org/uniprot/A0A8I5KTH0#function" }, { "database": "UniProtKB", "id": "A0A8I5KWA6", "url": "https://www.uniprot.org/uniprot/A0A8I5KWA6#function" }, { "database": "UniProtKB", "id": "A0A8I5KZ24", "url": "https://www.uniprot.org/uniprot/A0A8I5KZ24#function" }, { "database": "UniProtKB", "id": "A0A8I5KZ28", "url": "https://www.uniprot.org/uniprot/A0A8I5KZ28#function" }, { "database": "UniProtKB", "id": "A0A8I5KSC8", "url": "https://www.uniprot.org/uniprot/A0A8I5KSC8#function" } ] }, { "annotation": "Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, { "database": "PubMed", "id": "33330934", "url": "https://glygen.org/publication/PubMed/33330934" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, { "database": "PubMed", "id": "16385451", "url": "https://glygen.org/publication/PubMed/16385451" } ] }, { "annotation": "Study revealed a novel role of Ate1 in suppressing prostate cancer metastasis, which has a profound significance for establishing metastatic indicators for prostate cancer, and for finding potential treatments to prevent its metastasis.", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, { "database": "PubMed", "id": "30177837", "url": "https://glygen.org/publication/PubMed/30177837" } ] }, { "annotation": "The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" }, { "database": "PubMed", "id": "34896361", "url": "https://glygen.org/publication/PubMed/34896361" } ] }, { "annotation": "This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1395917531", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1395917531" }, { "id": "rs1395917531", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1395917531" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 108, "end_pos": 108, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KGS->NGS).", "chr_id": "10", "chr_pos": "121913803", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K108", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1340603446", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1340603446" }, { "id": "rs1340603446", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1340603446#frequency_tab" }, { "id": "rs1340603446", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1340603446" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 333, "end_pos": 333, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGP->NGS).", "chr_id": "10", "chr_pos": "121841242", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P333", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "84.29", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "79.67", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "86.61", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "82.55", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "89.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "86.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "80.71", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "89.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "80.79", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "79.66", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000107669", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000107669" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, 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"MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": 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"id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": 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"" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": 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This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "O95260", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95260" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of 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"A0A8I5QKM5", "url": "https://www.uniprot.org/uniprot/A0A8I5QKM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKM5-1", "url": "https://www.uniprot.org/uniprot/A0A8I5QKM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKV3", "url": "https://www.uniprot.org/uniprot/A0A8I5QKV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKV3-1", "url": "https://www.uniprot.org/uniprot/A0A8I5QKV3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKZ7", "url": "https://www.uniprot.org/uniprot/A0A8I5QKZ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKZ7-1", "url": "https://www.uniprot.org/uniprot/A0A8I5QKZ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F5GXE4", "url": "https://www.uniprot.org/uniprot/F5GXE4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F5GXE4-1", "url": "https://www.uniprot.org/uniprot/F5GXE4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WAC9", "url": "https://www.uniprot.org/uniprot/F8WAC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8WAC9-1", "url": "https://www.uniprot.org/uniprot/F8WAC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y5C2", "url": "https://www.uniprot.org/uniprot/H0Y5C2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y5C2-1", "url": "https://www.uniprot.org/uniprot/H0Y5C2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95260-1", "url": "https://www.uniprot.org/uniprot/O95260-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95260-2", "url": "https://www.uniprot.org/uniprot/O95260-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 518, "header": "sp|O95260-1|ATE1_HUMAN Isoform 1 of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2 CANONICAL=O95260-1" }, "isoforms": [ { "isoform_ac": "A0A8I5KNT9-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 497, "header": "tr|A0A8I5KNT9-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687583.1", "url": "https://www.ensembl.org/id/ENST00000687583.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508433.1", "url": "https://www.ensembl.org/id/ENSP00000508433.1" } ] } }, { "isoform_ac": "A0A8I5KNV5-1", "url": "", "sequence": { "sequence": "MWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 482, "header": "tr|A0A8I5KNV5-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121924327, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000686907.1", "url": "https://www.ensembl.org/id/ENST00000686907.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510093.1", "url": "https://www.ensembl.org/id/ENSP00000510093.1" } ] } }, { "isoform_ac": "A0A8I5KP66-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRR", "length": 57, "header": "tr|A0A8I5KP66-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121911151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690706.1", "url": "https://www.ensembl.org/id/ENST00000690706.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508994.1", "url": "https://www.ensembl.org/id/ENSP00000508994.1" } ] } }, { "isoform_ac": "A0A8I5KQ75-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 413, "header": "tr|A0A8I5KQ75-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000691765.1", "url": "https://www.ensembl.org/id/ENST00000691765.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509363.1", "url": "https://www.ensembl.org/id/ENSP00000509363.1" } ] } }, { "isoform_ac": "A0A8I5KQS6-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGSRSPTIFVSTKG", "length": 207, "header": "tr|A0A8I5KQS6-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121902467, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000691108.1", "url": "https://www.ensembl.org/id/ENST00000691108.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510097.1", "url": "https://www.ensembl.org/id/ENSP00000510097.1" } ] } }, { "isoform_ac": "A0A8I5KQW8-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTISSQDSFAVHPWRQRLPLMGQIVAMAPFTSSTGLTERSLLWG", "length": 118, "header": "tr|A0A8I5KQW8-1|A0A8I5KQW8_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121841176, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687607.1", "url": "https://www.ensembl.org/id/ENST00000687607.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510186.1", "url": "https://www.ensembl.org/id/ENSP00000510186.1" } ] } }, { "isoform_ac": "A0A8I5KR11-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRQRG", "length": 81, "header": "tr|A0A8I5KR11-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121902611, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684967.1", "url": "https://www.ensembl.org/id/ENST00000684967.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508860.1", "url": "https://www.ensembl.org/id/ENSP00000508860.1" } ] } }, { "isoform_ac": "A0A8I5KS65-1", "url": "", "sequence": { "sequence": "MWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 482, "header": "tr|A0A8I5KS65-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121924327, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689057.1", "url": "https://www.ensembl.org/id/ENST00000689057.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509905.1", "url": "https://www.ensembl.org/id/ENSP00000509905.1" } ] } }, { "isoform_ac": "A0A8I5KSC8-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAGMFGAELSWKSLALFL", "length": 475, "header": "tr|A0A8I5KSC8-1|A0A8I5KSC8_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121790122, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690415.1", "url": "https://www.ensembl.org/id/ENST00000690415.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509607.1", "url": "https://www.ensembl.org/id/ENSP00000509607.1" } ] } }, { "isoform_ac": "A0A8I5KSP7-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGSV", "length": 38, "header": "tr|A0A8I5KSP7-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121790282, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000693395.1", "url": "https://www.ensembl.org/id/ENST00000693395.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508971.1", "url": "https://www.ensembl.org/id/ENSP00000508971.1" } ] } }, { "isoform_ac": "A0A8I5KSU2-1", "url": "", "sequence": { "sequence": "MGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 113, "header": "tr|A0A8I5KSU2-1|A0A8I5KSU2_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121836759, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000693655.1", "url": "https://www.ensembl.org/id/ENST00000693655.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509079.1", "url": "https://www.ensembl.org/id/ENSP00000509079.1" } ] } }, { "isoform_ac": "A0A8I5KT53-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEFCLLQSLQAYLGDSVDLVPDHCNKAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 542, "header": "tr|A0A8I5KT53-1|A0A8I5KT53_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000691830.1", "url": "https://www.ensembl.org/id/ENST00000691830.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509345.1", "url": "https://www.ensembl.org/id/ENSP00000509345.1" } ] } }, { "isoform_ac": "A0A8I5KTG4-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNVHKIPLQFTLGGRDSP", "length": 51, "header": "tr|A0A8I5KTG4-1|A0A8I5KTG4_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121841250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000691226.1", "url": "https://www.ensembl.org/id/ENST00000691226.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510406.1", "url": "https://www.ensembl.org/id/ENSP00000510406.1" } ] } }, { "isoform_ac": "A0A8I5KTH0-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 511, "header": "tr|A0A8I5KTH0-1|A0A8I5KTH0_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689571.1", "url": "https://www.ensembl.org/id/ENST00000689571.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509590.1", "url": "https://www.ensembl.org/id/ENSP00000509590.1" } ] } }, { "isoform_ac": "A0A8I5KU86-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRR", "length": 50, "header": "tr|A0A8I5KU86-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121911151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000692491.1", "url": "https://www.ensembl.org/id/ENST00000692491.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508429.1", "url": "https://www.ensembl.org/id/ENSP00000508429.1" } ] } }, { "isoform_ac": "A0A8I5KUJ8-1", "url": "", "sequence": { "sequence": "FTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAGILKREPCRSWRPQKSK", "length": 162, "header": "tr|A0A8I5KUJ8-1|A0A8I5KUJ8_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121870038, "end_pos": 121709434, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690984.1", "url": "https://www.ensembl.org/id/ENST00000690984.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510447.1", "url": "https://www.ensembl.org/id/ENSP00000510447.1" } ] } }, { "isoform_ac": "A0A8I5KVF5-1", "url": "", "sequence": { "sequence": "MWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEKS", "length": 280, "header": "tr|A0A8I5KVF5-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121924327, "end_pos": 121890095, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687251.1", "url": "https://www.ensembl.org/id/ENST00000687251.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509863.1", "url": "https://www.ensembl.org/id/ENSP00000509863.1" } ] } }, { "isoform_ac": "A0A8I5KVR2-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 441, "header": "tr|A0A8I5KVR2-1|A0A8I5KVR2_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000693276.1", "url": "https://www.ensembl.org/id/ENST00000693276.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509714.1", "url": "https://www.ensembl.org/id/ENSP00000509714.1" } ] } }, { "isoform_ac": "A0A8I5KW01-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGEVSTCLL", "length": 202, "header": "tr|A0A8I5KW01-1|A0A8I5KW01_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121898947, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000692513.1", "url": "https://www.ensembl.org/id/ENST00000692513.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509908.1", "url": "https://www.ensembl.org/id/ENSP00000509908.1" } ] } }, { "isoform_ac": "A0A8I5KWA6-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEGLALLPKLECSGTISLHRNLCLPGSSDPPTSASRVAGSTETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 556, "header": "tr|A0A8I5KWA6-1|A0A8I5KWA6_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687089.1", "url": "https://www.ensembl.org/id/ENST00000687089.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510151.1", "url": "https://www.ensembl.org/id/ENSP00000510151.1" } ] } }, { "isoform_ac": "A0A8I5KWF1-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEGLALLPKLECSGTISLHRNLCLPGSSDPPTSASRVAGSTGRDSP", "length": 369, "header": "tr|A0A8I5KWF1-1|A0A8I5KWF1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121841250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000685890.1", "url": "https://www.ensembl.org/id/ENST00000685890.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509513.1", "url": "https://www.ensembl.org/id/ENSP00000509513.1" } ] } }, { "isoform_ac": "A0A8I5KWU7-1", "url": "", "sequence": { "sequence": "MWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEVYAQ", "length": 293, "header": "tr|A0A8I5KWU7-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121924327, "end_pos": 121857595, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687935.1", "url": "https://www.ensembl.org/id/ENST00000687935.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510701.1", "url": "https://www.ensembl.org/id/ENSP00000510701.1" } ] } }, { "isoform_ac": "A0A8I5KX41-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGADLYNFSLQNLTRRF", "length": 44, "header": "tr|A0A8I5KX41-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121913847, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000686894.1", "url": "https://www.ensembl.org/id/ENST00000686894.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508873.1", "url": "https://www.ensembl.org/id/ENSP00000508873.1" } ] } }, { "isoform_ac": "A0A8I5KX52-1", "url": "", "sequence": { "sequence": "AETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAAPSQTHRGSVLCILQSNQVDTQY", "length": 157, "header": "tr|A0A8I5KX52-1|A0A8I5KX52_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121841263, "end_pos": 121782632, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000485281.2", "url": "https://www.ensembl.org/id/ENST00000485281.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000510016.1", "url": "https://www.ensembl.org/id/ENSP00000510016.1" } ] } }, { "isoform_ac": "A0A8I5KX91-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEGLALLPKLECSGTISLHRNLCLPGSSDPPTSASRVAGSTGRDSP", "length": 362, "header": "tr|A0A8I5KX91-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121841250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690748.1", "url": "https://www.ensembl.org/id/ENST00000690748.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510080.1", "url": "https://www.ensembl.org/id/ENSP00000510080.1" } ] } }, { "isoform_ac": "A0A8I5KXB4-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCVHKIPLQFTLGGRDSP", "length": 44, "header": "tr|A0A8I5KXB4-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121841250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690128.1", "url": "https://www.ensembl.org/id/ENST00000690128.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508780.1", "url": "https://www.ensembl.org/id/ENSP00000508780.1" } ] } }, { "isoform_ac": "A0A8I5KXC6-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALRVSIDLLICCALRHMFGYPLSNACLHLKTPSTAVSTRTQKQWMRIAVRNLTDCRCFTREPSCLTVFIRNSRKTQVRRLLFCSTPAWWGRSAPSGCCCSETDLFTSAGKFLCCADDLCQDTYSVPVGK", "length": 512, "header": "tr|A0A8I5KXC6-1|A0A8I5KXC6_HUMAN Computationally mapped isoform of arginyltransferase OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743601, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000693486.1", "url": "https://www.ensembl.org/id/ENST00000693486.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510184.1", "url": "https://www.ensembl.org/id/ENSP00000510184.1" } ] } }, { "isoform_ac": "A0A8I5KXF6-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAGTGTDKVLLCCLGWSQIPGFKQFSCLGVPKGWDYMCEPLCPAFVKINHILS", "length": 510, "header": "tr|A0A8I5KXF6-1|A0A8I5KXF6_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121764328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000685072.1", "url": "https://www.ensembl.org/id/ENST00000685072.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510276.1", "url": "https://www.ensembl.org/id/ENSP00000510276.1" } ] } }, { "isoform_ac": "A0A8I5KXU0-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAGTGTDKVLLCCLGWSQIPGFKQFSCLGVPKGWDYMCEPLCPAFVKINHILS", "length": 510, "header": "tr|A0A8I5KXU0-1|A0A8I5KXU0_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121764328, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687458.1", "url": "https://www.ensembl.org/id/ENST00000687458.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509243.1", "url": "https://www.ensembl.org/id/ENSP00000509243.1" } ] } }, { "isoform_ac": "A0A8I5KY27-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGRDSP", "length": 40, "header": "tr|A0A8I5KY27-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121841250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000688424.1", "url": "https://www.ensembl.org/id/ENST00000688424.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509454.1", "url": "https://www.ensembl.org/id/ENSP00000509454.1" } ] } }, { "isoform_ac": "A0A8I5KYL1-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTESPSVAQAGAQSCDLGSLQPLPPEFRQFSYFSLPRSWDYRCAPPWPANFCIFSRDRILPC", "length": 373, "header": "tr|A0A8I5KYL1-1|A0A8I5KYL1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121878407, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000691087.1", "url": "https://www.ensembl.org/id/ENST00000691087.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510049.1", "url": "https://www.ensembl.org/id/ENSP00000510049.1" } ] } }, { "isoform_ac": "A0A8I5KZ10-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLERLPLMGQIVAMAPFTSSTGLTERSLLWG", "length": 346, "header": "tr|A0A8I5KZ10-1|A0A8I5KZ10_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121841176, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000688526.1", "url": "https://www.ensembl.org/id/ENST00000688526.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510389.1", "url": "https://www.ensembl.org/id/ENSP00000510389.1" } ] } }, { "isoform_ac": "A0A8I5KZ24-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 561, "header": "tr|A0A8I5KZ24-1|A0A8I5KZ24_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690355.1", "url": "https://www.ensembl.org/id/ENST00000690355.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510433.1", "url": "https://www.ensembl.org/id/ENSP00000510433.1" } ] } }, { "isoform_ac": "A0A8I5KZ28-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 497, "header": "tr|A0A8I5KZ28-1|A0A8I5KZ28_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000688057.1", "url": "https://www.ensembl.org/id/ENST00000688057.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510446.1", "url": "https://www.ensembl.org/id/ENSP00000510446.1" } ] } }, { "isoform_ac": "A0A8I5QJC4-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGEGGEIISTKFAVQSHTSGVLPGL", "length": 190, "header": "tr|A0A8I5QJC4-1|A0A8I5QJC4_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121899924, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000691041.1", "url": "https://www.ensembl.org/id/ENST00000691041.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509064.1", "url": "https://www.ensembl.org/id/ENSP00000509064.1" } ] } }, { "isoform_ac": "A0A8I5QJQ8-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIR", "length": 78, "header": "tr|A0A8I5QJQ8-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121911151, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684876.1", "url": "https://www.ensembl.org/id/ENST00000684876.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509855.1", "url": "https://www.ensembl.org/id/ENSP00000509855.1" } ] } }, { "isoform_ac": "A0A8I5QKM5-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPVHKIPLQFTLGGRDSP", "length": 210, "header": "tr|A0A8I5QKM5-1|A0A8I5QKM5_HUMAN Computationally mapped isoform of Arginyltransferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121841250, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000685427.1", "url": "https://www.ensembl.org/id/ENST00000685427.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509070.1", "url": "https://www.ensembl.org/id/ENSP00000509070.1" } ] } }, { "isoform_ac": "A0A8I5QKV3-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 434, "header": "tr|A0A8I5QKV3-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000690773.1", "url": "https://www.ensembl.org/id/ENST00000690773.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509670.1", "url": "https://www.ensembl.org/id/ENSP00000509670.1" } ] } }, { "isoform_ac": "A0A8I5QKZ7-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 87, "header": "tr|A0A8I5QKZ7-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689834.1", "url": "https://www.ensembl.org/id/ENST00000689834.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510230.1", "url": "https://www.ensembl.org/id/ENSP00000510230.1" } ] } }, { "isoform_ac": "F5GXE4-1", "url": "", "sequence": { "sequence": "MASVVEYKGLRAGYHCGYCDSKEGKASCGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 511, "header": "tr|F5GXE4-1|F5GXE4_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121928431, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000540606.7", "url": "https://www.ensembl.org/id/ENST00000540606.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000440881.1", "url": "https://www.ensembl.org/id/ENSP00000440881.1" } ] } }, { "isoform_ac": "F8WAC9-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 475, "header": "tr|F8WAC9-1|F8WAC9_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=1 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369040.9", "url": "https://www.ensembl.org/id/ENST00000369040.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000358036.4", "url": "https://www.ensembl.org/id/ENSP00000358036.4" } ] } }, { "isoform_ac": "H0Y5C2-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGADLYNFSLQNLTRRF", "length": 51, "header": "tr|H0Y5C2-1|ATE1_HUMAN Computationally mapped isoform of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121913847, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000686451.1", "url": "https://www.ensembl.org/id/ENST00000686451.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508510.1", "url": "https://www.ensembl.org/id/ENSP00000508510.1" } ] } }, { "isoform_ac": "O95260-1", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRVVRSSPPSSQFKATLLESYQVYKRYQMVIHKNPPDTPTESQFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 518, "header": "sp|O95260-1|ATE1_HUMAN Isoform 1 of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000224652.12", "url": "https://www.ensembl.org/id/ENST00000224652.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000224652.6", "url": "https://www.ensembl.org/id/ENSP00000224652.6" } ] } }, { "isoform_ac": "O95260-2", "url": "", "sequence": { "sequence": "MAFWAGGSPSVVDYFPSEDFYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEDEPMDSTMDDAVAGDFALINKLDIQCDLKTLSDDIKESLESEGKNSKKEEPQELLQSQDFVGEKLGSGEPSHSVKVHTVPKPGKGADLSKPPCRKAKEIRKERKRLKLMQQNPAGELEGFQAQGHPPSLFPPKAKSNQPKSLEDLIFESLPENASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEFTRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMKYKGQYRPSDLLCPETYVWVPIEQCLPSLENSKYCRFNQDPEAVDEDRSTEPDRLQVFHKRAIMPYGVYKKQQKDPSEEAAVLQYASLVGQKCSERMLLFRN", "length": 518, "header": "sp|O95260-2|ATE1_HUMAN Isoform 2 of Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2 CANONICAL=O95260-1" }, "locus": { "chromosome": "10", "start_pos": 121927949, "end_pos": 121743683, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369043.8", "url": "https://www.ensembl.org/id/ENST00000369043.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000358039.3", "url": "https://www.ensembl.org/id/ENSP00000358039.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 179, "start_aa": "Ser", "end_pos": 179, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser179", "evidence": [ { "id": "O95260", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95260" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95260", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95260" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 183, "start_aa": "Ser", "end_pos": 183, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser183", "evidence": [ { "id": "O95260", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95260" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O95260", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95260" } ] } ], "phosphorylation": [ { "start_pos": 169, "end_pos": 169, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "17525332", "url": "https://glygen.org/publication/PubMed/17525332" }, { "database": "iPTMnet", "id": "O95260", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95260" }, { "database": "PubMed", "id": "18077418", "url": "https://glygen.org/publication/PubMed/18077418" }, { "database": "phospho.ELM", "id": "O95260", "url": "http://phospho.elm.eu.org/byAccession/O95260.html" } ], "site_lbl": "Ser169" }, { "start_pos": 240, "end_pos": 240, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O95260", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95260" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser240" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.", "journal": "American journal of human genetics", "date": "2006", "authors": "Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrieze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ], "reference": [ { "type": "PubMed", "id": "16385451", "url": "https://glygen.org/publication/PubMed/16385451" } ] }, { "title": "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.", "journal": "Science (New York, N.Y.)", "date": "2007", "authors": "Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" }, { "database": "iPTMnet", "id": "O95260-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95260-1" } ], "reference": [ { "type": "PubMed", "id": "17525332", "url": "https://glygen.org/publication/PubMed/17525332" } ] }, { "title": "Profiling of UV-induced ATM/ATR signaling pathways.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ", "evidence": [ { "database": "iPTMnet", "id": "O95260-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95260-1" } ], "reference": [ { "type": "PubMed", "id": "18077418", "url": "https://glygen.org/publication/PubMed/18077418" } ] }, { "title": "Lysine acetylation targets protein complexes and co-regulates major cellular functions.", "journal": "Science", "date": "2009", "authors": "Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M", "evidence": [ { "database": "UniProtKB", "id": "F5GXE4", "url": "https://www.uniprot.org/uniprot/F5GXE4" } ], "reference": [ { "type": "PubMed", "id": "19608861", "url": "https://glygen.org/publication/PubMed/19608861" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O95260-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95260-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" }, { "database": "iPTMnet", "id": "O95260", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95260" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95260", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95260" }, { "database": "O-GlcNAc Atlas", "id": "O95260", "url": "https://oglcnac.org/atlas/detail/O95260" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis.", "journal": "Oncogene", "date": "2019", "authors": "Birnbaum MD, Zhao N, Moorthy BT, Patel DM, Kryvenko ON, Heidman L, Kumar A, Morgan WM, Ban Y, Reis IM, Chen X, Gonzalgo ML, Jorda M, Burnstein KL, Zhang F", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ], "reference": [ { "type": "PubMed", "id": "30177837", "url": "https://glygen.org/publication/PubMed/30177837" } ] }, { "title": "Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene.", "journal": "Nucleic acids research", "date": "2021", "authors": "Kalinina M, Skvortsov D, Kalmykova S, Ivanov T, Dontsova O, Pervouchine DD", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ], "reference": [ { "type": "PubMed", "id": "33330934", "url": "https://glygen.org/publication/PubMed/33330934" } ] }, { "title": "ATE1 Inhibits Liver Cancer Progression through RGS5-Mediated Suppression of Wnt/beta-Catenin Signaling.", "journal": "Molecular cancer research : MCR", "date": "2021", "authors": "Xu C, Li YM, Sun B, Zhong FJ, Yang LY", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ], "reference": [ { "type": "PubMed", "id": "34158395", "url": "https://glygen.org/publication/PubMed/34158395" } ] }, { "title": "Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core.", "journal": "Retrovirology", "date": "2021", "authors": "Kishimoto N, Okano R, Akita A, Miura S, Irie A, Takamune N, Misumi S", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ], "reference": [ { "type": "PubMed", "id": "34565409", "url": "https://glygen.org/publication/PubMed/34565409" } ] }, { "title": "The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.", "journal": "Journal of molecular biology", "date": "2022", "authors": "Drazic A, Timmerman E, Kajan U, Marie M, Varland S, Impens F, Gevaert K, Arnesen T", "evidence": [ { "database": "RefSeq", "id": "NP_001001976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001976" } ], "reference": [ { "type": "PubMed", "id": "34896361", "url": "https://glygen.org/publication/PubMed/34896361" } ] }, { "title": "Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.", "journal": "Mol. Cell. Biol.", "date": "1999", "authors": "Kwon Y T, Kashina A S, Varshavsky A", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" } ], "reference": [ { "type": "PubMed", "id": "9858543", "url": "https://glygen.org/publication/PubMed/9858543" } ] } ], "pathway": [ { "id": "hsa:11101", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11101", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AL43-1", "protein_name": "Arginyl-tRNA--protein transferase 1", "gene_name": "Ate1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASWSAPSPSLVEYFEGQTSFQCGYCKSNFGSRSHGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQTCCPQYTIRCHPLQFQPSKSHKKVLKKMLKFLAKGEISKGNCEDEPMDSTMEDAVDGDFALMNKLDIKCDLKTLSSDLKVSIESEEKEKEKSLKKEGSKDLIHPQAIEEKLGSGEPSHSIKVHVGPKPGKGADLSKPPCRKAKEMRKERKRLKLMQQSSAGAFEGFQAQGQPVSLLPKAKSNQPKSLEDLIFESLPEDASHKLEVRVVRSSPPSPQFKATFQESYQVYKRYQMIIHKDPPDKPTVSQFTRFLCNSPLEAEHPANGPECGYGSFHQQYWLDGKIIAVGVIDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMRYKGQYRPSDLLCPETYVWVPIEQCLPSLDNSKYCRFNQDPQAEDEGRSKELDRLRVFHRRSAMPYGVYKNHQEDPSEEAVVLEYANLVGQKCSETMLLFRH", "length": 520 }, "evidence": [ { "id": "45928831", "url": "http://www.informatics.jax.org/homology/45928831", "database": "MGI" }, { "id": "O95260", "url": "https://omabrowser.org/oma/group/O95260/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O96539-1", "protein_name": "Arginyl-tRNA--protein transferase 1", "gene_name": "Ate1", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSLSIVSYYGSQQSKCGYCAGANCSLSHGMHAYQLDCRDYQDLIDRGWRRCGYYCYKLRNQETCCPCYTIKCNGLEFKLSKSNKRILRRINRFLRDGKRESKPEAGDGDGEADADYAIVAPEVTASEPQPQLPDKSPPVINVEQVASLATAQRKPTKQATAAAVEAPTLGSNKSSLLSSSAAAPISNKPCKKAKQMRLDRRLAKLGDSASYSTKSLTQEKTLRDFLNTDSETNKHRLKLRLIHVYDDEFRRTLPQSFALYKKYQISIHNDPPKDQDAYKEHLQATPLQNEKPWDGPEMGYGSFHQQYWLDDKLIAVGVIDILPGCVSSVYFFYDPDYSFLSLGTYGSLREIELVQSLAEKVPSLKYYYMGFYIHSCPKMRYKGKLSPSYLLCPETYEWLPLTDVIRAKLDEHKYQRLNEDPAARDVNEFLMEHLDEVKLLLGGRTRTDYKHFRQLRGTVSDDDIIIEYSKLVGKECARRMLYVK", "length": 484 }, "evidence": [ { "id": "O95260", "url": "https://omabrowser.org/oma/group/O95260/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9Z2A5-1", "protein_name": "Arginyl-tRNA--protein transferase 1", "gene_name": "Ate1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASWSAPSPSLVEYFEGQTSFQCGYCKNKLGSRSYGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMDQTCCPQYTIRCHPLQFQPSKSHKKVLKKMLKFLAKGEISKGNCEDEPMDSTVEDAVDGDFALINKLDIKCDLKTLSDLKGSIESEEKEKEKSIKKEGSKEFIHPQSIEEKLGSGEPSHPIKVHIGPKPGKGADLSKPPCRKAREMRKERQRLKRMQQASAAASEAQGQPVCLLPKAKSNQPKSLEDLIFQSLPENASHKLEVRVVRSSPPSPQFRATFQESYQVYKRYQMVVHKDPPDKPTVSQFTRFLCSSPLEAEHPADGPECGYGSFHQQYWLDGKIIAVGVLDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPKMRYKGQYRPSDLLCPETYVWVPIEQCLPSLDNSKYCRFNQDPEAEDEGRSKELDRLRVFHRRSAMPYGVYKNHQEDPSEEAGVLEYANLVGQKCSERMLLFRH", "length": 516 }, "evidence": [ { "id": "45928831", "url": "http://www.informatics.jax.org/homology/45928831", "database": "MGI" }, { "id": "O95260", "url": "https://omabrowser.org/oma/group/O95260/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "arginyl-tRNA--protein transferase activity", "id": "GO:0004057", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004057", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasomal protein catabolic process", "id": "GO:0010498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" } ], "pmid": "" }, { "name": "protein arginylation", "id": "GO:0016598", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016598", "evidence": [ { "database": "UniProtKB", "id": "O95260", "url": "https://www.uniprot.org/uniprot/O95260" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 265, "end_pos": 267, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10208", "name": "", "equation": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I6AL43-1", "O95260-1", "Q9Z2A5-1", "P16639-1", "Q55EI0-1", "O96539-1" ], "evidence": [ { "id": "10208", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10208" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6AL43", "gene_name": "Ate1", "activity": [ { "ec_number": "2.3.2.8", "activity": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).", "evidence": [ { "id": "A0A8I6AL43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL43" } ] }, { "ec_number": "2.3.2.8", "activity": "", "evidence": [ { "id": "A0A8I6AL43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AL43" } ] } ] }, { "uniprot_ac": "O95260", "gene_name": "ATE1", "activity": [ { "ec_number": "2.3.2.8", "activity": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).", "evidence": [ { "id": "O95260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95260" } ] }, { "ec_number": "2.3.2.8", "activity": "", "evidence": [ { "id": "O95260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95260" } ] } ] }, { "uniprot_ac": "O96539", "gene_name": "Ate1", "activity": [ { "ec_number": "2.3.2.8", "activity": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).", "evidence": [ { "id": "O96539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O96539" } ] }, { "ec_number": "2.3.2.8", "activity": "", "evidence": [ { "id": "O96539", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O96539" } ] } ] }, { "uniprot_ac": "P16639", "gene_name": "ATE1", "activity": [ { "ec_number": "2.3.2.8", "activity": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).", "evidence": [ { "id": "P16639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16639" } ] }, { "ec_number": "2.3.2.8", "activity": "", "evidence": [ { "id": "P16639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16639" } ] } ] }, { "uniprot_ac": "Q55EI0", "gene_name": "ate1", "activity": [ { "ec_number": "2.3.2.8", "activity": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).", "evidence": [ { "id": "Q55EI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EI0" } ] }, { "ec_number": "2.3.2.8", "activity": "", "evidence": [ { "id": "Q55EI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55EI0" } ] } ] }, { "uniprot_ac": "Q9Z2A5", "gene_name": "Ate1", "activity": [ { "ec_number": "2.3.2.8", "activity": "an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = H(+) + N-terminal L-arginyl-L-amino acid-[protein] + tRNA(Arg).", "evidence": [ { "id": "Q9Z2A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z2A5" } ] }, { "ec_number": "2.3.2.8", "activity": "", "evidence": [ { "id": "Q9Z2A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z2A5" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 179, 183 ], "snv_sites": [ 108, 333 ], "glycation_sites": [], "phosphorylation_sites": [ 169, 240 ], "sequon_annotation_sites": [ { "start_pos": 265, "end_pos": 267 }, { "start_pos": 28, "end_pos": 30 }, { "start_pos": 68, "end_pos": 70 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 13 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }