{ "uniprot_canonical_ac": "O95185-1", "uniprot_ac": "O95185", "uniprot_id": "UNC5C_HUMAN", "mass": { "chemical_mass": 103146.0, "monoisotopic_mass": 103146.0 }, "refseq": { "ac": "NP_003719", "name": "netrin receptor UNC5C precursor", "summary": "This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, "gene_names": [ { "name": "UNC5C", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95185", "id": "O95185" }, { "name": "UNC5C", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719", "id": "NP_003719" }, { "name": "UNC5H3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719", "id": "NP_003719" }, { "name": "UNC5H3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O95185", "id": "O95185" } ], "protein_names": [ { "name": "Netrin receptor UNC5C", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95185" }, { "name": "Protein unc-5 homolog 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95185" }, { "name": "Protein unc-5 homolog C", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O95185" }, { "name": "netrin receptor UNC5C precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719", "id": "NP_003719" }, { "name": "unc5 (C.elegans homolog) c; unc-5 homolog 3; protein unc-5 homolog C; protein unc-5 homolog 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719", "id": "NP_003719" } ], "function": [ { "annotation": "A global integrated analysis of UNC5C down-regulation in cancers: insights from mechanism and combined treatment strategy.", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, { "database": "PubMed", "id": "33706130", "url": "https://glygen.org/publication/PubMed/33706130" } ] }, { "annotation": "An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, { "database": "PubMed", "id": "30883345", "url": "https://glygen.org/publication/PubMed/30883345" } ] }, { "annotation": "Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, { "database": "PubMed", "id": "35709926", "url": "https://glygen.org/publication/PubMed/35709926" } ] }, { "annotation": "May represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, { "database": "PubMed", "id": "12655055", "url": "https://glygen.org/publication/PubMed/12655055" } ] }, { "annotation": "Promoter Hypermethylation of UNC5C Gene is associated with Colorectal Cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, { "database": "PubMed", "id": "29801399", "url": "https://glygen.org/publication/PubMed/29801399" } ] }, { "annotation": "Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185#function" }, { "database": "UniProtKB", "id": "Q761X5", "url": "https://www.uniprot.org/uniprot/Q761X5#function" }, { "database": "UniProtKB", "id": "O08747", "url": "https://www.uniprot.org/uniprot/O08747#function" }, { "database": "PubMed", "id": "28483977", "url": "https://glygen.org/publication/PubMed/28483977" } ] }, { "annotation": "Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.", "evidence": [ { "database": "UniProtKB", "id": "E0CX15", "url": "https://www.uniprot.org/uniprot/E0CX15#function" }, { "database": "UniProtKB", "id": "RU367033", "url": "https://www.uniprot.org/uniprot/RU367033#function" } ] }, { "annotation": "This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ] }, { "annotation": "UNC5Cknockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin alpha6/beta4 signaling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" }, { "database": "PubMed", "id": "31789389", "url": "https://glygen.org/publication/PubMed/31789389" } ] } ], "disease": [ { "disease_id": "DOID:0080348", "recommended_name": { "id": "DOID:0080348", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080348", "name": "Alzheimer's disease 1", "description": "An Alzheimer's disease that has_material_basis_in mutation heterozygous mutation in the APP gene, which encodes the amyloid precursor protein, on chromosome 21q21." }, "synonyms": [ { "id": "DOID:0080348", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080348", "name": "Alzheimer's disease 1, early onset", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease type 1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "early-onset familial form of Alzheimer disease", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease 1, familial", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "AD", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "AD1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease 1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, early-onset, with cerebral amyloid angiopathy", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, familial, 1", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, late-onset, susceptibility to", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, protection against", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "Alzheimer disease, susceptibility to", "description": "" }, { "id": "MONDO:0007088", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007088", "name": "presenile and senile dementia", "description": "" }, { "id": "MIM:104300", "resource": "MIM", "url": "https://www.omim.org/entry/104300", "name": "Alzheimer disease 1", "description": "Alzheimer disease 1" } ], "evidence": [ { "id": "104300", "database": "MIM", "url": "https://www.omim.org/entry/104300" } ] } ], "snv": [ { "evidence": [ { "id": "rs1579267497", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1579267497" }, { "id": "rs1579267497", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1579267497" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 238, "end_pos": 238, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->NYP).", "chr_id": "4", "chr_pos": "95250550", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T238", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O95185", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O95185" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 265, "end_pos": 265, "subjects_tested": "585", "subjects_positive": "1", "frequency": "0.2", "sequence_org": "T", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (TWT->NWT).", "chr_id": "4", "chr_pos": "95245126", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T265", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": 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"https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, 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"" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": 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"id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": 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"http://www.orthodb.org/?query=2971005at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10075", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10075", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12582", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12582", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12582:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12582:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00090", "url": "http://pfam.xfam.org/family/PF00090", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00531", "url": "http://pfam.xfam.org/family/PF00531", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00791", "url": "http://pfam.xfam.org/family/PF00791", "database": "Pfam", "categories": [ "Protein 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"MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 931, "header": "sp|O95185-1|UNC5C_HUMAN Isoform 1 of Netrin receptor UNC5C OS=Homo sapiens OX=9606 GN=UNC5C PE=1 SV=2 CANONICAL=O95185-1" }, "isoforms": [ { "isoform_ac": "D6RE16-1", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYGP", "length": 260, "header": "tr|D6RE16-1|UNC5C_HUMAN Computationally mapped isoform of Netrin receptor UNC5C OS=Homo sapiens OX=9606 GN=UNC5C PE=1 SV=1 CANONICAL=O95185-1" }, "locus": { "chromosome": "4", "start_pos": 95548857, "end_pos": 95248612, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000504962.1", "url": "https://www.ensembl.org/id/ENST00000504962.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000425117.1", "url": "https://www.ensembl.org/id/ENSP00000425117.1" } ] } }, { "isoform_ac": "E0CX15-1", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQSFIYPISTEQRTQNEYGFSSAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLL", "length": 745, "header": "tr|E0CX15-1|E0CX15_HUMAN Computationally mapped isoform of Netrin receptor UNC5 OS=Homo sapiens OX=9606 GN=UNC5C PE=1 SV=1 CANONICAL=O95185-1" }, "locus": { "chromosome": "4", "start_pos": 95548857, "end_pos": 95185155, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000513796.5", "url": "https://www.ensembl.org/id/ENST00000513796.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000426924.1", "url": "https://www.ensembl.org/id/ENSP00000426924.1" } ] } }, { "isoform_ac": "O95185-1", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 931, "header": "sp|O95185-1|UNC5C_HUMAN Isoform 1 of Netrin receptor UNC5C OS=Homo sapiens OX=9606 GN=UNC5C PE=1 SV=2 CANONICAL=O95185-1" }, "locus": { "chromosome": "4", "start_pos": 95548857, "end_pos": 95169237, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000453304.6", "url": "https://www.ensembl.org/id/ENST00000453304.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000406022.1", "url": "https://www.ensembl.org/id/ENSP00000406022.1" } ] } }, { "isoform_ac": "O95185-2", "url": "", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQSFIYPISTEQRTQNEYGFSSAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMR", "length": 597, "header": "sp|O95185-2|UNC5C_HUMAN Isoform 2 of Netrin receptor UNC5C OS=Homo sapiens OX=9606 GN=UNC5C PE=1 SV=2 CANONICAL=O95185-1" }, "locus": { "chromosome": "4", "start_pos": 95548857, "end_pos": 95216123, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000506749.5", "url": "https://www.ensembl.org/id/ENST00000506749.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000426153.1", "url": "https://www.ensembl.org/id/ENSP00000426153.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 236, "start_aa": "Asn", "end_pos": 236, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn236", "evidence": [ { "id": "O95185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95185#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 361, "start_aa": "Asn", "end_pos": 361, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn361", "evidence": [ { "id": "O95185", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95185#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 570, "start_aa": "Thr", "end_pos": 570, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr570", "evidence": [ { "id": "O95185", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95185" }, { "id": "31492838", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31492838" }, { "id": "O95185", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O95185" } ] } ], "phosphorylation": [ { "start_pos": 449, "end_pos": 449, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "PRO", "id": "O95185", "url": "http://purl.obolibrary.org/obo/O95185" }, { "database": "iPTMnet", "id": "O95185", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95185" } ], "site_lbl": "Tyr449" }, { "start_pos": 454, "end_pos": 454, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "PRO", "id": "O95185", "url": "http://purl.obolibrary.org/obo/O95185" }, { "database": "iPTMnet", "id": "O95185", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95185" } ], "site_lbl": "Tyr454" }, { "start_pos": 502, "end_pos": 502, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "site_lbl": "Ser502" }, { "start_pos": 568, "end_pos": 568, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" }, { "database": "PRO", "id": "O95185", "url": "http://purl.obolibrary.org/obo/O95185" }, { "database": "iPTMnet", "id": "O95185", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95185" } ], "site_lbl": "Tyr568" }, { "start_pos": 649, "end_pos": 649, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "PRO", "id": "O95185", "url": "http://purl.obolibrary.org/obo/O95185" }, { "database": "iPTMnet", "id": "O95185", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95185" } ], "site_lbl": "Tyr649" }, { "start_pos": 667, "end_pos": 667, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "PRO", "id": "O95185", "url": "http://purl.obolibrary.org/obo/O95185" }, { "database": "iPTMnet", "id": "O95185", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O95185" } ], "site_lbl": "Tyr667" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" }, { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ], "reference": [ { "type": "PubMed", "id": "12655055", "url": "https://glygen.org/publication/PubMed/12655055" } ] }, { "title": "Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.", "journal": "J. Biol. Chem.", "date": "2012", "authors": "Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "reference": [ { "type": "PubMed", "id": "22685302", "url": "https://glygen.org/publication/PubMed/22685302" } ] }, { "title": "Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles.", "journal": "World journal of gastroenterology", "date": "2014", "authors": "Kury S, Garrec C, Airaud F, Breheret F, Guibert V, Frenard C, Jiao S, Bonneau D, Berthet P, Bossard C, Ingster O, Cauchin E, Bezieau S", "evidence": [ { "database": "Entrez", "id": "8633", "url": "https://www.ncbi.nlm.nih.gov/gene/8633" } ], "reference": [ { "type": "PubMed", "id": "24415873", "url": "https://glygen.org/publication/PubMed/24415873" } ] }, { "title": "A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.", "journal": "Nature medicine", "date": "2014", "authors": "Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "reference": [ { "type": "PubMed", "id": "25419706", "url": "https://glygen.org/publication/PubMed/25419706" } ] }, { "title": "An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid beta Precursor Protein Signaling.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "reference": [ { "type": "PubMed", "id": "27068745", "url": "https://glygen.org/publication/PubMed/27068745" } ] }, { "title": "Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2017", "authors": "Shao Q, Yang T, Huang H, Alarmanazi F, Liu G", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "reference": [ { "type": "PubMed", "id": "28483977", "url": "https://glygen.org/publication/PubMed/28483977" } ] }, { "title": "Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage Disease", "journal": "Asian Pacific journal of cancer prevention : APJCP", "date": "2018", "authors": "Guroo SA, Malik AA, Afroze D, Ali S, Pandith AA, Yusuf A", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ], "reference": [ { "type": "PubMed", "id": "29801399", "url": "https://glygen.org/publication/PubMed/29801399" } ] }, { "title": "An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.", "journal": "Journal of Alzheimer's disease : JAD", "date": "2019", "authors": "Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ], "reference": [ { "type": "PubMed", "id": "30883345", "url": "https://glygen.org/publication/PubMed/30883345" } ] }, { "title": "Next-generation unnatural monosaccharides reveal that ESRRB O-GlcNAcylation regulates pluripotency of mouse embryonic stem cells.", "journal": "Nature communications", "date": "2019", "authors": "Hao Y, Fan X, Shi Y, Zhang C, Sun DE, Qin K, Qin W, Zhou W, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O95185", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O95185" }, { "database": "O-GlcNAc Atlas", "id": "O95185", "url": "https://oglcnac.org/atlas/detail/O95185" } ], "reference": [ { "type": "PubMed", "id": "31492838", "url": "https://glygen.org/publication/PubMed/31492838" } ] }, { "title": "UNC5Cknockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin alpha6/beta4 signaling pathway.", "journal": "International journal of oncology", "date": "2020", "authors": "Yuan M, Xie F, Xia X, Zhong K, Lian L, Zhang S, Yuan L, Ye J", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ], "reference": [ { "type": "PubMed", "id": "31789389", "url": "https://glygen.org/publication/PubMed/31789389" } ] }, { "title": "A global integrated analysis of UNC5C down-regulation in cancers: insights from mechanism and combined treatment strategy.", "journal": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie", "date": "2021", "authors": "Xing H, Wang P, Liu S, Jing S, Lin J, Yang J, Zhu Y, Yu M", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ], "reference": [ { "type": "PubMed", "id": "33706130", "url": "https://glygen.org/publication/PubMed/33706130" } ] }, { "title": "Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis.", "journal": "Genomics", "date": "2022", "authors": "Wang H, Zhou Z, Liu Y, Wang P, Chen L, Qi S, Xie J, Tang J", "evidence": [ { "database": "RefSeq", "id": "NP_003719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003719" } ], "reference": [ { "type": "PubMed", "id": "35709926", "url": "https://glygen.org/publication/PubMed/35709926" } ] }, { "title": "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.", "journal": "Genomics", "date": "1998", "authors": "Ackerman S L, Knowles B B", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "reference": [ { "type": "PubMed", "id": "9782087", "url": "https://glygen.org/publication/PubMed/9782087" } ] } ], "pathway": [ { "id": "hsa:8633", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8633", "resource": "KEGG Pathway" }, { "id": "R-HSA-418886", "name": "Netrin mediated repulsion signals", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418886", "resource": "Reactome", "description": "Netrin mediated repulsion signals" } ], "orthologs": [ { "uniprot_canonical_ac": "O08747-1", "protein_name": "Netrin receptor UNC5C", "gene_name": "Unc5c", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDEFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPAEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPSTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 931 }, "evidence": [ { "id": "45922235", "url": "http://www.informatics.jax.org/homology/45922235", "database": "MGI" }, { "id": "O95185", "url": "https://omabrowser.org/oma/group/O95185/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q761X5-1", "protein_name": "Netrin receptor UNC5C", "gene_name": "Unc5c", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPMAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWAEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVTVCLAITVVVALFVYRKNHRDFESNIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNSSGAVTPQDDLAEFSSKLSPQMTQSLLENEALNLKNQSLARQTDPSCTAFGTFNSLGGHLIIPNSGVSLLIPAGAIPQGRVYEMYVTVHRKENMRPPMEDSQTLLTPVVSCGPPGALLTRPVILTLHHCADPNTEDWKIQLKNQAVQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGQSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKALHFKGSIHNLRLSIHDITHSLWKSKLLAKYQEIPFYHIWSGSQRNLHCTFTLERLSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPASTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY", "length": 931 }, "evidence": [ { "id": "45922235", "url": "http://www.informatics.jax.org/homology/45922235", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "pmid": "" }, { "name": "lamellipodium", "id": "GO:0030027", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027", "evidence": [ { "database": "UniProtKB", "id": "O95185", "url": "https://www.uniprot.org/uniprot/O95185" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { 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