{ "uniprot_canonical_ac": "O95073-1", "uniprot_ac": "O95073", "uniprot_id": "FSBP_HUMAN", "mass": { "chemical_mass": 34768.0, "monoisotopic_mass": 34768.0 }, "refseq": { "ac": "NP_001192191", "name": "DNA repair and recombination protein RAD54B isoform 2", "summary": "The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" }, "gene_names": [ { "name": "FSBP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O95073", "id": "O95073" }, { "name": "RAD54B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191", "id": "NP_001192191" }, { "name": "RDH54", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191", "id": "NP_001192191" } ], "protein_names": [ { "name": "Fibrinogen silencer-binding protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O95073" }, { "name": "DNA repair and recombination protein RAD54B isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191", "id": "NP_001192191" }, { "name": "DNA repair and recombination protein RAD54B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191", "id": "NP_001192191" } ], "function": [ { "annotation": "Integrated study of miR-215 promoting breast cancer cell apoptosis by targeting RAD54B.", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" }, { "database": "PubMed", "id": "33635591", "url": "https://glygen.org/publication/PubMed/33635591" } ] }, { "annotation": "RAD54B mutations enhance the sensitivity of ovarian cancer cells to poly(ADP-ribose) polymerase (PARP) inhibitors.", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" }, { "database": "PubMed", "id": "35952757", "url": "https://glygen.org/publication/PubMed/35952757" } ] }, { "annotation": "RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" }, { "database": "PubMed", "id": "36196684", "url": "https://glygen.org/publication/PubMed/36196684" } ] }, { "annotation": "Rad54B enhanced the DNA strand-exchange activity of Dmc1 by stabilizing the Dmc1-single-stranded DNA complex.", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" }, { "database": "PubMed", "id": "16945962", "url": "https://glygen.org/publication/PubMed/16945962" } ] }, { "annotation": "Rad54B is a DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" }, { "database": "PubMed", "id": "11884632", "url": "https://glygen.org/publication/PubMed/11884632" } ] }, { "annotation": "The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" } ] }, { "annotation": "Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.", "evidence": [ { "database": "UniProtKB", "id": "O95073", "url": "https://www.uniprot.org/uniprot/O95073#function" }, { "database": "PubMed", "id": "20531236", "url": "https://glygen.org/publication/PubMed/20531236" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "66", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "65.85", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "66.15", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "62.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "67.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "57.98", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "55.24", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "62.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "63.07", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O95073", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95073" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" 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cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O95073", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O95073" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95073", "url": "https://www.uniprot.org/uniprot/O95073" } ], "common_name": "Human" } ], "gene": [ { "name": "FSBP", "url": "https://www.uniprot.org/uniprot/O95073", "locus": { "chromosome": "8", "start_pos": 94378377, "end_pos": 94436952, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000265817", "url": "https://www.ensembl.org/id/ENSG00000265817" } ] } } ], "crossref": [ { "id": "ENSG00000265817", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000265817", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FSBP", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=FSBP", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "100861412", "url": "https://www.ncbi.nlm.nih.gov/gene/100861412", "database": "GeneID", 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"https://pharos.nih.gov/targets/O95073", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O95073", "url": "http://purl.obolibrary.org/obo/PR_O95073", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "J3KSW4", "url": "https://www.uniprot.org/uniprot/J3KSW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KSW4-1", "url": "https://www.uniprot.org/uniprot/J3KSW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95073", "url": "https://www.uniprot.org/uniprot/O95073", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95073-1", "url": "https://www.uniprot.org/uniprot/O95073-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O95073-2", "url": "https://www.uniprot.org/uniprot/O95073-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVGKARSSNFTLSEKLDLLKLVKPYVKILEEHTNKHSVIVEKNRCWDIIAVNYNAIGVDRPPRTAQGLRTLYKRLKEYAKQELLQQKETQSDFKSNISEPTKKVMEMIPQISSFCLVRDRNHIQSANLDEEAQAGTSSLQVMLDHHPVAITVEVKQEEDIKPPPPLVLNSQQSDTLEQREEHELVHVMERSLSPSLSSVDMRMTSSPSSIPRRDDFFRHESGEHFRSLLGYDPQILQMLKEEHQIILENQKNFGLYVQEKRDGLKRRQQLEEELLRAKIEVEKLKAIRLRHDLPEYNSL", "length": 299, "header": "sp|O95073-1|FSBP_HUMAN Isoform 1 of Fibrinogen silencer-binding protein OS=Homo sapiens OX=9606 GN=FSBP PE=1 SV=1 CANONICAL=O95073-1" }, "isoforms": [ { "isoform_ac": "J3KSW4-1", "url": "", "sequence": { "sequence": "MVGKARSSNFTLSEKLDLLKLVKPYVKILEEHTNKHSVIVEKNRCWDIIAVNYNAIGVDRPPRTAQGLRTLYKRLKEYAKQELLQQKETQSDFKSNISEPTKKVMEMIPQISSFCLVRDRNHIQSSFGS", "length": 129, "header": "tr|J3KSW4-1|J3KSW4_HUMAN Computationally mapped isoform of Fibrinogen silencer binding protein OS=Homo sapiens OX=9606 GN=FSBP PE=1 SV=1 CANONICAL=O95073-1" }, "locus": { "chromosome": "8", "start_pos": 94436868, "end_pos": 94411303, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000517506.2", "url": "https://www.ensembl.org/id/ENST00000517506.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000462684.1", "url": "https://www.ensembl.org/id/ENSP00000462684.1" } ] } }, { "isoform_ac": "O95073-1", "url": "", "sequence": { "sequence": "MVGKARSSNFTLSEKLDLLKLVKPYVKILEEHTNKHSVIVEKNRCWDIIAVNYNAIGVDRPPRTAQGLRTLYKRLKEYAKQELLQQKETQSDFKSNISEPTKKVMEMIPQISSFCLVRDRNHIQSANLDEEAQAGTSSLQVMLDHHPVAITVEVKQEEDIKPPPPLVLNSQQSDTLEQREEHELVHVMERSLSPSLSSVDMRMTSSPSSIPRRDDFFRHESGEHFRSLLGYDPQILQMLKEEHQIILENQKNFGLYVQEKRDGLKRRQQLEEELLRAKIEVEKLKAIRLRHDLPEYNSL", "length": 299, "header": "sp|O95073-1|FSBP_HUMAN Isoform 1 of Fibrinogen silencer-binding protein OS=Homo sapiens OX=9606 GN=FSBP PE=1 SV=1 CANONICAL=O95073-1" }, "locus": { "chromosome": "8", "start_pos": 94436868, "end_pos": 94432134, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000481490.3", "url": "https://www.ensembl.org/id/ENST00000481490.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000420405.2", "url": "https://www.ensembl.org/id/ENSP00000420405.2" } ] } }, { "isoform_ac": "O95073-2", "url": "", "sequence": { "sequence": "MLDHHPVAITVEVKQEEDIKPPPPLVLNSQQSDTLEQREEHELVHVMERSLSPSLSSVDMRMTSSPSSIPRRDDFFRHESGEHFRSLLGYDPQILQMLKEEHQIILENQKNFGLYVQEKRDGLKRRQQLEEELLRAKIEVEKLKAIRLRHDLPEYNSL", "length": 158, "header": "sp|O95073-2|FSBP_HUMAN Isoform 2 of Fibrinogen silencer-binding protein OS=Homo sapiens OX=9606 GN=FSBP PE=1 SV=1 CANONICAL=O95073-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54.", "journal": "Nucleic acids research", "date": "2002", "authors": "Tanaka K, Kagawa W, Kinebuchi T, Kurumizaka H, Miyagawa K", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" } ], "reference": [ { "type": "PubMed", "id": "11884632", "url": "https://glygen.org/publication/PubMed/11884632" } ] }, { "title": "Stimulation of Dmc1-mediated DNA strand exchange by the human Rad54B protein.", "journal": "Nucleic acids research", "date": "2006", "authors": "Sarai N, Kagawa W, Kinebuchi T, Kagawa A, Tanaka K, Miyagawa K, Ikawa S, Shibata T, Kurumizaka H, Yokoyama S", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" } ], "reference": [ { "type": "PubMed", "id": "16945962", "url": "https://glygen.org/publication/PubMed/16945962" } ] }, { "title": "An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.", "journal": "Neuroreport", "date": "2010", "authors": "Lau KF, Perkinton MS, Rodriguez L, McLoughlin DM, Miller CC", "evidence": [ { "database": "UniProtKB", "id": "O95073", "url": "https://www.uniprot.org/uniprot/O95073" } ], "reference": [ { "type": "PubMed", "id": "20531236", "url": "https://glygen.org/publication/PubMed/20531236" } ] }, { "title": "Integrated study of miR-215 promoting breast cancer cell apoptosis by targeting RAD54B.", "journal": "Journal of cellular and molecular medicine", "date": "2021", "authors": "Wang M, Liao J, Tan C, Zhou H, Wang J, Wang K, Li Y, Wu W", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" } ], "reference": [ { "type": "PubMed", "id": "33635591", "url": "https://glygen.org/publication/PubMed/33635591" } ] }, { "title": "RAD54B mutations enhance the sensitivity of ovarian cancer cells to poly(ADP-ribose) polymerase (PARP) inhibitors.", "journal": "The Journal of biological chemistry", "date": "2022-09", "authors": "Liu Peng, Lin Chunxiu, Liu Lanlan, Lu Ziwen, Tu Zhigang, Liu Hanqing", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" } ], "reference": [ { "type": "PubMed", "id": "35952757", "url": "https://glygen.org/publication/PubMed/35952757" } ] }, { "title": "RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.", "journal": "International endodontic journal", "date": "2023-01", "authors": "Huang Pei, Wang Fushi, Wang Xinhuan, Meng Xiujiao, Qiao Weiwei, Meng Liuyan", "evidence": [ { "database": "RefSeq", "id": "NP_001192191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192191" } ], "reference": [ { "type": "PubMed", "id": "36196684", "url": "https://glygen.org/publication/PubMed/36196684" } ] } ], "pathway": [ { "id": "hsa:100861412", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:100861412", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8BKE5-1", "protein_name": "Fibrinogen silencer-binding protein", "gene_name": "Fsbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVGKARSSNFTLSEKLDLLNLVKPYVKILEEHTNKNSVIVEKNRCWDVIAVNYNAIGVDRPPRTAQGLRSLYKRLKEYAKQELLQQKEAQSEFKSSVSEPTKQVMEMIPQIASFGLIRDRSHIQSANLDETAQAGTSSLQVMVDHHPVAITVEVKQEEDIKPSPPLVSNPQLSDTLEQREEHELMHVVEGSESPSLSSVDMRMTSSPSSVPRRDEIFHQESGEHFRSLLRCDPQVLQMLKEEHQIILENQKNFGLYVQEKRDGLRRRQRLEEELLRAKIEVEKLKATRLRRDLPEYSSL", "length": 299 }, "evidence": [ { "id": "45926651", "url": "http://www.informatics.jax.org/homology/45926651", "database": "MGI" }, { "id": "45933841", "url": "http://www.informatics.jax.org/homology/45933841", "database": "MGI" }, { "id": "O95073", "url": "https://omabrowser.org/oma/group/O95073/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O95073", "url": 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"label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 96, "end_pos": 98 }, { "start_pos": 9, "end_pos": 11 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, 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