{ "uniprot_canonical_ac": "O94972-1", "uniprot_ac": "O94972", "uniprot_id": "TRI37_HUMAN", "mass": { "chemical_mass": 107906.0, "monoisotopic_mass": 107906.0 }, "refseq": { "ac": "NP_001005207", "name": "E3 ubiquitin-protein ligase TRIM37 isoform a", "summary": "This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" }, "gene_names": [ { "name": "TRIM37", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O94972", "id": "O94972" }, { "name": "KIAA0898", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94972", "id": "O94972" }, { "name": "MUL; POB1; TEF3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207", "id": "NP_001005207" }, { "name": "MUL", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94972", "id": "O94972" }, { "name": "POB1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94972", "id": "O94972" }, { "name": "TRIM37", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207", "id": "NP_001005207" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM37", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O94972" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94972" }, { "name": "E3 ubiquitin-protein ligase TRIM37 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207", "id": "NP_001005207" }, { "name": "Mulibrey nanism protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94972" }, { "name": "RING-B-box-coiled-coil protein; E3 ubiquitin-protein ligase TRIM37; mulibrey nanism protein; RING-type E3 ubiquitin transferase TRIM37", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207", "id": "NP_001005207" }, { "name": "RING-type E3 ubiquitin transferase TRIM37", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94972" }, { "name": "Tripartite motif-containing protein 37", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94972" } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724).", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972#function" }, { "database": "PubMed", "id": "15885686", "url": "https://glygen.org/publication/PubMed/15885686" }, { "database": "PubMed", "id": "24317724", "url": "https://glygen.org/publication/PubMed/24317724" }, { "database": "PubMed", "id": "25470042", "url": "https://glygen.org/publication/PubMed/25470042" }, { "database": "PubMed", "id": "23769972", "url": "https://glygen.org/publication/PubMed/23769972" }, { "database": "PubMed", "id": "28724525", "url": "https://glygen.org/publication/PubMed/28724525" } ] }, { "annotation": "Liver pathology and biochemistry in patients with mutations in TRIM37 gene (Mulibrey nanism).", "evidence": [ { "database": "RefSeq", "id": "NP_001005207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" }, { "database": "PubMed", "id": "35220664", "url": "https://glygen.org/publication/PubMed/35220664" } ] }, { "annotation": "TRIM37 Augments AP-2gamma Transcriptional Activity and Cellular Localization via K63-linked Ubiquitination to Drive Breast Cancer Progression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001005207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" }, { "database": "PubMed", "id": "35864973", "url": "https://glygen.org/publication/PubMed/35864973" } ] }, { "annotation": "TRIM37 Promotes Pancreatic Cancer Progression through Modulation of Cell Growth, Migration, Invasion, and Tumor Immune Microenvironment. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001005207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" }, { "database": "PubMed", "id": "35163097", "url": "https://glygen.org/publication/PubMed/35163097" } ] }, { "annotation": "TRIM37 orchestrates renal cell carcinoma progression via histone H2A ubiquitination-dependent manner. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001005207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" }, { "database": "PubMed", "id": "34130705", "url": "https://glygen.org/publication/PubMed/34130705" } ] }, { "annotation": "TRIM37 promotes the aggressiveness of ovarian cancer cells and increases c-Myc expression by binding to HUWE1.", "evidence": [ { "database": "RefSeq", "id": "NP_001005207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" }, { "database": "PubMed", "id": "35921902", "url": "https://glygen.org/publication/PubMed/35921902" } ] }, { "annotation": "This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. Mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. TRIM37 localizes in peroxisomal membranes, and has been implicated in human peroxisomal biogenesis disorders. [provided by RefSeq, Jul 2020].", "evidence": [ { "database": "RefSeq", "id": "NP_001005207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005207" } ] } ], "disease": [ { "disease_id": "DOID:0050436", "recommended_name": { "id": "DOID:0050436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050436", "name": "mulibrey nanism", "description": "A syndrome that is characterized by global growth retardation of the muscle, liver, brain and eyes as well as constrictive pericarditis and has_material_basis_in mutations in the TRIM37 gene." }, "synonyms": [ { "id": "DOID:0050436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050436", "name": "MUL", "description": "" }, { "id": "DOID:0050436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050436", "name": "Mulibrey growth disorder", "description": "" }, { "id": "DOID:0050436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050436", "name": "Muscle-Liver-Brain-Eye Nanism", "description": "" }, { "id": "DOID:0050436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050436", "name": "PERICARDIAL CONSTRICTION AND GROWTH FAILURE", "description": "" }, { "id": "DOID:0050436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050436", "name": "Perheentupa Syndrome", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "mulibrey nanism", "description": "A prenatal onset growth disorder with multiorgan manifestations." }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "MUL", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "Perheentupa syndrome", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "mulibrey dwarfism", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "mulibrey nanism", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "muscle-liver-brain-eye nanism", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "pericardial constriction and growth failure", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "pericardial constriction-growth failure syndrome", "description": "" }, { "id": "MONDO:0009664", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009664", "name": "pericardial constriction and Growth failure", "description": "" }, { "id": "MIM:253250", "resource": "MIM", "url": "https://www.omim.org/entry/253250", "name": "Mulibrey nanism", "description": "Mulibrey nanism" } ], "evidence": [ { "id": "253250", "database": "MIM", "url": "https://www.omim.org/entry/253250" } ] } ], "snv": [ { "evidence": [ { "id": "rs768272469", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768272469" }, { "id": "rs768272469", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768272469" }, { "id": "rs768272469", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768272469" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 195, "end_pos": 195, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->I).", "chr_id": "17", "chr_pos": "59079786", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T195", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs768272469", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768272469" }, { "id": "rs768272469", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768272469" }, { "id": "rs768272469", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768272469" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 195, "end_pos": 195, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->R).", "chr_id": "17", "chr_pos": "59079786", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T195", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs200009152", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200009152" }, { "id": "rs200009152", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs200009152" }, { "id": "rs200009152", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200009152" }, { "id": "rs200009152", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs200009152#frequency_tab" }, { "id": "rs200009152", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs200009152" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 233, "end_pos": 233, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SKS->NKS).", "chr_id": "17", "chr_pos": "59070934", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "S233", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O94972", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94972" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 267, "end_pos": 267, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DFT->NFT).", "chr_id": "17", "chr_pos": "59070833", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D267", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O94972", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O94972" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O94972", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O94972" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O94972" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR", "length": 964, "header": "sp|O94972-1|TRI37_HUMAN Isoform 1 of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=2 CANONICAL=O94972-1" }, "isoforms": [ { "isoform_ac": "J3KS72-1", "url": "", "sequence": { "sequence": "MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRVSLCRPGRSAMA", "length": 67, "header": "tr|J3KS72-1|TRI37_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=1 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59106461, "end_pos": 59090056, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000577554.5", "url": "https://www.ensembl.org/id/ENST00000577554.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000462340.1", "url": "https://www.ensembl.org/id/ENSP00000462340.1" } ] } }, { "isoform_ac": "J3KT32-1", "url": "", "sequence": { "sequence": "XTDLENNSETGELQPVLPEGASAAPEEDTHSSFPDGEQIGPEDLSFNTDENSGR", "length": 54, "header": "tr|J3KT32-1|J3KT32_HUMAN Computationally mapped isoform of Tripartite motif containing 37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=4 SV=1 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59012407, "end_pos": 58982919, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000583945.5", "url": "https://www.ensembl.org/id/ENST00000583945.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000462778.1", "url": "https://www.ensembl.org/id/ENSP00000462778.1" } ] } }, { "isoform_ac": "J3KT90-1", "url": "", "sequence": { "sequence": "VNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQGASCFWKKWCQGRIYTLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVV", "length": 194, "header": "tr|J3KT90-1|TRI37_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=8 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59081162, "end_pos": 59061091, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000581468.1", "url": "https://www.ensembl.org/id/ENST00000581468.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000462863.1", "url": "https://www.ensembl.org/id/ENSP00000462863.1" } ] } }, { "isoform_ac": "J3QRK3-1", "url": "", "sequence": { "sequence": "MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKYVLNFFVQY", "length": 103, "header": "tr|J3QRK3-1|TRI37_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=1 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59106461, "end_pos": 59088263, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000584889.3", "url": "https://www.ensembl.org/id/ENST00000584889.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000464263.1", "url": "https://www.ensembl.org/id/ENSP00000464263.1" } ] } }, { "isoform_ac": "J3QSA0-1", "url": "", "sequence": { "sequence": "MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRKGM", "length": 58, "header": "tr|J3QSA0-1|TRI37_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=1 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59106461, "end_pos": 59079868, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000580973.5", "url": "https://www.ensembl.org/id/ENST00000580973.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464590.1", "url": "https://www.ensembl.org/id/ENSP00000464590.1" } ] } }, { "isoform_ac": "J3QSF6-1", "url": "", "sequence": { "sequence": "TLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEETCSPSFLPGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR", "length": 117, "header": "tr|J3QSF6-1|TRI37_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=1 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59015617, "end_pos": 58982921, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000585287.5", "url": "https://www.ensembl.org/id/ENST00000585287.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464666.1", "url": "https://www.ensembl.org/id/ENSP00000464666.1" } ] } }, { "isoform_ac": "J3QSH5-1", "url": "", "sequence": { "sequence": "XDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDNMADIPLNLWQKFMSNTSLK", "length": 113, "header": "tr|J3QSH5-1|TRI37_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=1 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59106459, "end_pos": 59081160, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000580122.5", "url": "https://www.ensembl.org/id/ENST00000580122.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464688.1", "url": "https://www.ensembl.org/id/ENSP00000464688.1" } ] } }, { "isoform_ac": "O94972-1", "url": "", "sequence": { "sequence": "MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR", "length": 964, "header": "sp|O94972-1|TRI37_HUMAN Isoform 1 of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=2 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59106461, "end_pos": 58999380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000262294.12", "url": "https://www.ensembl.org/id/ENST00000262294.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000262294.7", "url": "https://www.ensembl.org/id/ENSP00000262294.7" } ] } }, { "isoform_ac": "O94972-2", "url": "", "sequence": { "sequence": "MHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEDTHSSFPDGEQIGPEDLSFNTDENSGR", "length": 803, "header": "sp|O94972-2|TRI37_HUMAN Isoform 2 of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=2 CANONICAL=O94972-1" }, "locus": {} }, { "isoform_ac": "O94972-3", "url": "", "sequence": { "sequence": "MDEQSVERWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR", "length": 930, "header": "sp|O94972-3|TRI37_HUMAN Isoform 3 of E3 ubiquitin-protein ligase TRIM37 OS=Homo sapiens OX=9606 GN=TRIM37 PE=1 SV=2 CANONICAL=O94972-1" }, "locus": { "chromosome": "17", "start_pos": 59106461, "end_pos": 58999380, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000393065.6", "url": "https://www.ensembl.org/id/ENST00000393065.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000376784.2", "url": "https://www.ensembl.org/id/ENSP00000376784.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 195, "start_aa": "Thr", "end_pos": 195, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr195", "evidence": [ { "id": "O94972", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94972" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O94972", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O94972" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 195, "start_aa": "Thr", "end_pos": 195, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr195", "evidence": [ { "id": "GLY_000142", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000142" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "phosphorylation": [ { "start_pos": 454, "end_pos": 454, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O94972", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94972" } ], "site_lbl": "Ser454" }, { "start_pos": 771, "end_pos": 771, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O94972", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94972" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Ser771" }, { "start_pos": 773, "end_pos": 773, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O94972", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94972" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Ser773" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Gene encoding a new RING-B-box-coiled-coil protein is mutated in mulibrey nanism.", "journal": "Nat. Genet.", "date": "2000", "authors": "Avela K, Lipsanen-Nyman M, Id\u00e4nheimo N, Seemanov\u00e1 E, Rosengren S, M\u00e4kel\u00e4 T P, Perheentupa J, Chapelle A D, Lehesjoki A E", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "reference": [ { "type": "PubMed", "id": "10888877", "url": "https://glygen.org/publication/PubMed/10888877" } ] }, { "title": "Two new proteases in the MHC class I processing pathway.", "journal": "Nature immunology", "date": "2000", "authors": "Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11062501", "url": "https://glygen.org/publication/PubMed/11062501" } ] }, { "title": "26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.", "journal": "The EMBO journal", "date": "2001", "authors": "Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11350924", "url": "https://glygen.org/publication/PubMed/11350924" } ] }, { "title": "The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil protein: classification of mulibrey nanism as a new peroxisomal disorder.", "journal": "Am. J. Hum. Genet.", "date": "2002", "authors": "Kallijarvi J, Avela K, Lipsanen-Nyman M, Ulmanen I, Lehesjoki AE", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "reference": [ { "type": "PubMed", "id": "11938494", "url": "https://glygen.org/publication/PubMed/11938494" } ] }, { "title": "U-box proteins as a new family of ubiquitin ligases.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hatakeyama S, Nakayama KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "12646216", "url": "https://glygen.org/publication/PubMed/12646216" } ] }, { "title": "A novel splice site mutation in the TRIM37 gene causes mulibrey nanism in a Turkish family with phenotypic heterogeneity.", "journal": "Hum. Mutat.", "date": "2003", "authors": "Jagiello P, Hammans C, Wieczorek S, Arning L, Stefanski A, Strehl H, Epplen J T, Gencik M", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "reference": [ { "type": "PubMed", "id": "12754710", "url": "https://glygen.org/publication/PubMed/12754710" } ] }, { "title": "Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.", "journal": "Current opinion in immunology", "date": "2004", "authors": "Kloetzel PM, Ossendorp F", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "14734113", "url": "https://glygen.org/publication/PubMed/14734113" } ] }, { "title": "Novel mutations in the TRIM37 gene in Mulibrey Nanism.", "journal": "Human mutation", "date": "2004", "authors": "Hamalainen RH, Avela K, Lambert JA, Kallijarvi J, Eyaid W, Gronau J, Ignaszewski AP, McFadden D, Sorge G, Lipsanen-Nyman M, Lehesjoki AE", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "reference": [ { "type": "PubMed", "id": "15108285", "url": "https://glygen.org/publication/PubMed/15108285" } ] }, { "title": "Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.", "journal": "Nature immunology", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224091", "url": "https://glygen.org/publication/PubMed/15224091" } ] }, { "title": "Post-proteasomal antigen processing for major histocompatibility complex class I presentation.", "journal": "Nature immunology", "date": "2004", "authors": "Rock KL, York IA, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", 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chemistry", "date": "1998", "authors": "Beninga J, Rock KL, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "9668046", "url": "https://glygen.org/publication/PubMed/9668046" } ] } ], "pathway": [ { "id": "hsa:4591", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4591", "resource": "KEGG Pathway" }, { "id": "R-HSA-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZJG0-1", "protein_name": "Tripartite motif-containing 37", "gene_name": "Trim37", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNRQNDTVILRFQVRSPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDSPETRTKKAGSCSDMLLEGGPTCASVRETKEDEDEEEKIQNEDYHHELSDGDLDLDLVGEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNSMELEEGELMEDAAAAGPPGSSHSYVGASSRMSRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSMENLWGLQPRPSASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKTTLSDIKGSSVASTDMQTNLFCADQAALTTCGPENSGRLQDLGMELLAKSSVAGCYIRNPTNKKNSPKSARAIAGSLSLRRAVDSGENSRSKGDCQVLAEGSSGSSQSGSRHSSPRALTHGIIGDLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVTLGTNAKGGRLEGMQMADLESHSEAGEVQPTLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSMGAFNDPFLAQPPDEDSHSSFPDGEQIDPENLHFNPDEGGGR", "length": 961 }, "evidence": [ { "id": "45928213", "url": "http://www.informatics.jax.org/homology/45928213", "database": "MGI" }, { "id": "O94972", "url": "https://omabrowser.org/oma/group/O94972/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 10, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "ubiquitin protein ligase binding", "id": "GO:0031625", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "tumor necrosis factor receptor binding", "id": "GO:0005164", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005164", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "histone H2AK119 ubiquitin ligase activity", "id": "GO:0140862", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140862", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "positive regulation of DNA-binding transcription factor activity", "id": "GO:0051091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051091", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "positive regulation of NF-kappaB transcription factor activity", "id": "GO:0051092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051092", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "negative regulation of NF-kappaB transcription factor activity", "id": "GO:0032088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032088", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "negative regulation of gene expression, epigenetic", "id": "GO:0045814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045814", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "protein import into peroxisome matrix", "id": "GO:0016558", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016558", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "negative regulation of centriole replication", "id": "GO:0046600", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046600", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "aggresome assembly", "id": "GO:0070842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070842", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "peroxisome", "id": "GO:0005777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005777", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "peroxisomal membrane", "id": "GO:0005778", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005778", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" }, { "name": "aggresome", "id": "GO:0016235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016235", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 285, "end_pos": 287, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 752, "end_pos": 754, "annotation": "n_glycosylation_sequon" }, { "start_pos": 877, "end_pos": 879, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Auto-ubiquitinated.", "evidence": [ { "database": "UniProtKB", "id": "O94972", "url": "https://www.uniprot.org/uniprot/O94972" }, { "database": "PubMed", "id": "15885686", "url": "https://glygen.org/publication/PubMed/15885686" } ] } ], "interactions": [], "reactions": [ { "id": "R-HSA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983140" } ] }, { "id": "R-HSA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O95376-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9Y508-1", "Q6ZNA4-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P46934-1", "Q14139-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1" ], "evidence": [ { "id": "R-HSA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983147" } ] }, { "id": "R-HSA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983156" } ] }, { "id": "R-HSA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00762", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] } ] }, { "uniprot_ac": "O14933", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14933" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14933" } ] } ] }, { "uniprot_ac": "O15033", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15033" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15033" } ] } ] }, { "uniprot_ac": "O43164", "gene_name": "PJA2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43164" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43164" } ] } ] }, { "uniprot_ac": "O43255", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43255" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43255" } ] } ] }, { "uniprot_ac": "O60260", "gene_name": "PRKN", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] }, { "ec_number": "6.3.2.19", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] } ] }, { "uniprot_ac": "O60291", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60291" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60291" } ] } ] }, { "uniprot_ac": "O94822", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94822" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94822" } ] } ] }, { "uniprot_ac": "O94874", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "O94874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94874" } ] } ] }, { "uniprot_ac": "O94941", "gene_name": "UBOX5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94941" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94941" } ] } ] }, { "uniprot_ac": "O94972", "gene_name": "TRIM37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94972" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94972" } ] } ] }, { "uniprot_ac": "O95376", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95376" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95376" } ] } ] }, { "uniprot_ac": "O95714", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95714" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95714" } ] } ] }, { "uniprot_ac": "P19474", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19474" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19474" } ] } ] }, { "uniprot_ac": "P41226", "gene_name": "UBA7", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P41226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41226" } ] } ] }, { "uniprot_ac": "P46934", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46934" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46934" } ] } ] }, { "uniprot_ac": "P49427", "gene_name": "CDC34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] } ] }, { "uniprot_ac": "P49459", "gene_name": "UBE2A", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49459" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49459" } ] } ] }, { "uniprot_ac": "P51668", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] } ] }, { "uniprot_ac": "P51965", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] } ] }, { "uniprot_ac": "P60604", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60604" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60604" } ] } ] }, { "uniprot_ac": "P61077", "gene_name": "UBE2D3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] } ] }, { "uniprot_ac": "P61081", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61081" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61081" } ] } ] }, { "uniprot_ac": "P61086", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61086" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61086" } ] } ] }, { "uniprot_ac": "P61088", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61088" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61088" } ] } ] }, { "uniprot_ac": "P62253", "gene_name": "UBE2G1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62253" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62253" } ] } ] }, { "uniprot_ac": "P62256", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] }, { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] } ] }, { "uniprot_ac": "P62837", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] } ] }, { "uniprot_ac": "P62877", "gene_name": "RBX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] } ] }, { "uniprot_ac": "P63146", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63146" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63146" } ] } ] }, { "uniprot_ac": "P68036", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68036" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68036" } ] } ] }, { "uniprot_ac": "P78317", "gene_name": "RNF4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78317" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78317" } ] } ] }, { "uniprot_ac": "Q05086", "gene_name": "UBE3A", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05086" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05086" } ] } ] }, { "uniprot_ac": "Q13049", "gene_name": "TRIM32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13049" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13049" } ] } ] }, { "uniprot_ac": "Q13191", "gene_name": "CBLB", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13191" } ] } ] }, { "uniprot_ac": "Q14139", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14139" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14139" } ] } ] }, { "uniprot_ac": "Q14669", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14669" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14669" } ] } ] }, { "uniprot_ac": "Q15034", "gene_name": "HERC3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15034" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15034" } ] } ] }, { "uniprot_ac": "Q15386", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15386" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15386" } ] } ] }, { "uniprot_ac": "Q15751", "gene_name": "HERC1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15751" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15751" } ] } ] }, { "uniprot_ac": "Q16763", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] } ] }, { "uniprot_ac": "Q2Q1W2", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2Q1W2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2Q1W2" } ] } ] }, { "uniprot_ac": "Q5GLZ8", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GLZ8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GLZ8" } ] } ] }, { "uniprot_ac": "Q5T447", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T447" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T447" } ] } ] }, { "uniprot_ac": "Q5T4S7", "gene_name": "UBR4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T4S7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T4S7" } ] } ] }, { "uniprot_ac": "Q5U5Q3", "gene_name": "MEX3C", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5Q3" } ] } ] }, { "uniprot_ac": "Q5U5R9", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5R9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5R9" } ] } ] }, { "uniprot_ac": "Q5VTB9", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VTB9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VTB9" } ] } ] }, { "uniprot_ac": "Q5VVX9", "gene_name": "UBE2U", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VVX9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VVX9" } ] } ] }, { "uniprot_ac": "Q5XPI4", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI4" } ] } ] }, { "uniprot_ac": "Q63HN8", "gene_name": "RNF213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] } ] }, { "uniprot_ac": "Q6Q0C0", "gene_name": "TRAF7", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] } ] }, { "uniprot_ac": "Q6UWE0", "gene_name": "LRSAM1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWE0" } ] } ] }, { "uniprot_ac": "Q6ZMZ0", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMZ0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMZ0" } ] } ] }, { "uniprot_ac": "Q6ZNA4", "gene_name": "RNF111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZNA4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZNA4" } ] } ] }, { "uniprot_ac": "Q712K3", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q712K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q712K3" } ] } ] }, { "uniprot_ac": "Q7Z3V4", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3V4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3V4" } ] } ] }, { "uniprot_ac": "Q7Z419", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z419" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z419" } ] } ] }, { "uniprot_ac": "Q7Z6E9", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6E9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6E9" } ] } ] }, { "uniprot_ac": "Q7Z6J0", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J0" } ] } ] }, { "uniprot_ac": "Q7Z6J8", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J8" } ] } ] }, { "uniprot_ac": "Q7Z6Z7", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z7" } ] } ] }, { "uniprot_ac": "Q7Z7E8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z7E8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z7E8" } ] } ] }, { "uniprot_ac": "Q86WT6", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WT6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WT6" } ] } ] }, { "uniprot_ac": "Q86XS8", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XS8" } ] } ] }, { "uniprot_ac": "Q86XT4", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XT4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XT4" } ] } ] }, { "uniprot_ac": "Q86Y13", "gene_name": "DZIP3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y13" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y13" } ] } ] }, { "uniprot_ac": "Q8IUQ4", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUQ4" } ] } ] }, { "uniprot_ac": "Q8IVU3", "gene_name": "HERC6", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IVU3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IVU3" } ] } ] }, { "uniprot_ac": "Q8IWV7", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV7" } ] } ] }, { "uniprot_ac": "Q8IWV8", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV8" } ] } ] }, { "uniprot_ac": "Q8IYU2", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IYU2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IYU2" } ] } ] }, { "uniprot_ac": "Q8N2K1", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K1" } ] } ] }, { "uniprot_ac": "Q8N6D2", "gene_name": "RNF182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6D2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6D2" } ] } ] }, { "uniprot_ac": "Q8N7E2", "gene_name": "CBLL2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N7E2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N7E2" } ] } ] }, { "uniprot_ac": "Q8ND25", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ND25" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ND25" } ] } ] }, { "uniprot_ac": "Q8NG27", "gene_name": "PJA1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG27" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG27" } ] } ] }, { "uniprot_ac": "Q8NHG8", "gene_name": "ZNRF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHG8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHG8" } ] } ] }, { "uniprot_ac": "Q8TBB1", "gene_name": "LNX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBB1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBB1" } ] } ] }, { "uniprot_ac": "Q8TC41", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC41" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC41" } ] } ] }, { "uniprot_ac": "Q8TDB6", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDB6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDB6" } ] } ] }, { "uniprot_ac": "Q8WV44", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WV44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WV44" } ] } ] }, { "uniprot_ac": "Q8WVD3", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVD3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVD3" } ] } ] }, { "uniprot_ac": "Q8WVN8", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVN8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVN8" } ] } ] }, { "uniprot_ac": "Q8WY64", "gene_name": "MYLIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY64" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY64" } ] } ] }, { "uniprot_ac": "Q969K3", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969K3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969K3" } ] } ] }, { "uniprot_ac": "Q969M7", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969M7" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969M7" } ] } ] }, { "uniprot_ac": "Q969Q1", "gene_name": "TRIM63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969Q1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969Q1" } ] } ] }, { "uniprot_ac": "Q969T4", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969T4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969T4" } ] } ] }, { "uniprot_ac": "Q96AX9", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AX9" } ] } ] }, { "uniprot_ac": "Q96B02", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.25", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] } ] }, { "uniprot_ac": "Q96BH1", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BH1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BH1" } ] } ] }, { "uniprot_ac": "Q96F44", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96F44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96F44" } ] } ] }, { "uniprot_ac": "Q96J02", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J02" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J02" } ] } ] }, { "uniprot_ac": "Q96LR5", "gene_name": "UBE2E2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LR5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LR5" } ] } ] }, { "uniprot_ac": "Q96PM5", "gene_name": "RCHY1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PM5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PM5" } ] } ] }, { "uniprot_ac": "Q96PU5", "gene_name": "NEDD4L", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] } ] }, { "uniprot_ac": "Q9BV68", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV68" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV68" } ] } ] }, { "uniprot_ac": "Q9BWF2", "gene_name": "TRAIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWF2" } ] } ] }, { "uniprot_ac": "Q9BYM8", "gene_name": "RBCK1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYM8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYM8" } ] } ] }, { "uniprot_ac": "Q9C026", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C026" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C026" } ] } ] }, { "uniprot_ac": "Q9C037", "gene_name": "TRIM4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C037" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C037" } ] } ] }, { "uniprot_ac": "Q9C0C9", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C0C9" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C0C9" } ] } ] }, { "uniprot_ac": "Q9H0M0", "gene_name": "WWP1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0M0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0M0" } ] } ] }, { "uniprot_ac": "Q9H4P4", "gene_name": "RNF41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4P4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4P4" } ] } ] }, { "uniprot_ac": "Q9H832", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H832" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H832" } ] } ] }, { "uniprot_ac": "Q9H9P5", "gene_name": "UNKL", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9H9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H9P5" } ] } ] }, { "uniprot_ac": "Q9HAU4", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAU4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAU4" } ] } ] }, { "uniprot_ac": "Q9HCE7", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCE7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCE7" } ] } ] }, { "uniprot_ac": "Q9HCM9", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCM9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCM9" } ] } ] }, { "uniprot_ac": "Q9NQ86", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQ86" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQ86" } ] } ] }, { "uniprot_ac": "Q9NV58", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV58" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV58" } ] } ] }, { "uniprot_ac": "Q9NVW2", "gene_name": "RLIM", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVW2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVW2" } ] } ] }, { "uniprot_ac": "Q9P2P5", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P2P5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P2P5" } ] } ] }, { "uniprot_ac": "Q9UBS8", "gene_name": "RNF14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBS8" } ] } ] }, { "uniprot_ac": "Q9UHC7", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHC7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHC7" } ] } ] }, { "uniprot_ac": "Q9UII4", "gene_name": "HERC5", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9UII4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UII4" } ] } ] }, { "uniprot_ac": "Q9ULT8", "gene_name": "HECTD1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULT8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULT8" } ] } ] }, { "uniprot_ac": "Q9UNE7", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNE7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNE7" } ] } ] }, { "uniprot_ac": "Q9Y252", "gene_name": "RNF6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y252" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y252" } ] } ] }, { "uniprot_ac": "Q9Y2X8", "gene_name": "UBE2D4", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2X8" } ] } ] }, { "uniprot_ac": "Q9Y385", "gene_name": "UBE2J1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y385" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y385" } ] } ] }, { "uniprot_ac": "Q9Y4B6", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4B6" } ] } ] }, { "uniprot_ac": "Q9Y4L5", "gene_name": "RNF115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4L5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4L5" } ] } ] }, { "uniprot_ac": "Q9Y508", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 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"start_pos": 752, "end_pos": 754 }, { "start_pos": 877, "end_pos": 879 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 13 }, { "field": "total_sites", "count": 11 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", 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