{ "uniprot_canonical_ac": "O94898-1", "uniprot_ac": "O94898", "uniprot_id": "LRIG2_HUMAN", "mass": { "chemical_mass": 118965.0, "monoisotopic_mass": 118965.0 }, "refseq": { "ac": "NP_001299615", "name": "leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2", "summary": "This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, "gene_names": [ { "name": "LRIG2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O94898", "id": "O94898" }, { "name": "KIAA0806", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94898", "id": "O94898" }, { "name": "LIG-2; LIG2; UFS2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615", "id": "NP_001299615" }, { "name": "LIG2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94898", "id": "O94898" }, { "name": "LRIG2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615", "id": "NP_001299615" } ], "protein_names": [ { "name": "Leucine-rich repeats and immunoglobulin-like domains protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O94898" }, { "name": "LIG-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94898" }, { "name": "leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615", "id": "NP_001299615" }, { "name": "leucine-rich repeats and immunoglobulin-like domains protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615", "id": "NP_001299615" } ], "function": [ { "annotation": "A SINE-VNTR-Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "33187279", "url": "https://glygen.org/publication/PubMed/33187279" } ] }, { "annotation": "A subset of urofacial syndrome-affected individuals have biallelic mutations in LRIG2", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "23313374", "url": "https://glygen.org/publication/PubMed/23313374" } ] }, { "annotation": "LRIG proteins may have a role in epidermal homeostasis and psoriasis", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "18037903", "url": "https://glygen.org/publication/PubMed/18037903" } ] }, { "annotation": "LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "33469151", "url": "https://glygen.org/publication/PubMed/33469151" } ] }, { "annotation": "LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "36183058", "url": "https://glygen.org/publication/PubMed/36183058" } ] }, { "annotation": "LRIG2 was found to be a glycoprotein with an molecular weight of 132 kDa, which was encoded by a gene on human chromosome 1p13 and its mRNA was present in all tissues analyzed.", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "15145052", "url": "https://glygen.org/publication/PubMed/15145052" } ] }, { "annotation": "Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" }, { "database": "PubMed", "id": "34839782", "url": "https://glygen.org/publication/PubMed/34839782" } ] }, { "annotation": "This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ] } ], "disease": [ { "disease_id": "DOID:0050816", "recommended_name": { "id": "DOID:0050816", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050816", "name": "urofacial syndrome", "description": "A syndrome that is characterized by inverted facial expressions in association with a severe and early-onset form of dysfunctional urinary voiding." }, "synonyms": [ { "id": "DOID:0050816", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050816", "name": "Ochoa syndrome", "description": "" }, { "id": "DOID:0050816", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050816", "name": "hydronephrosis with peculiar facial expression", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "urofacial syndrome type 1", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "urofacial syndrome type 1", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "Ochoa syndrome", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "UFS1", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "facial palsy, partial, with urinary abnormalities", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "hydronephrosis with peculiar Facial expression", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "inverted smile and occult neuropathic bladder", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "urofacial syndrome", "description": "" }, { "id": "MONDO:0009368", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009368", "name": "urofacial syndrome 1", "description": "" }, { "id": "MONDO:0014049", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014049", "name": "urofacial syndrome 2", "description": "Any Ochoa syndrome in which the cause of the disease is a mutation in the LRIG2 gene." }, { "id": "MONDO:0014049", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014049", "name": "LRIG2 Ochoa syndrome", "description": "" }, { "id": "MONDO:0014049", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014049", "name": "Ochoa 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"database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777636936" }, { "id": "rs777636936", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777636936" }, { "id": "rs777636936", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs777636936" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1001, "end_pos": 1001, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIN->NIS).", "chr_id": "1", "chr_pos": "113123905", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N1001", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1350982821", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1350982821" }, { "id": "rs1350982821", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1350982821" } ], "glycoeffect": [ 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"germline" ] }, { "evidence": [ { "id": "O94898", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94898" }, { "id": "rs1317010200", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1317010200" }, { "id": "rs1317010200", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1317010200" }, { "id": "rs1317010200", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1317010200" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 107, "end_pos": 107, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NYN->NYS).", "chr_id": "1", "chr_pos": "113093220", "ref_nt": "A", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "N107", "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": 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"rs1311707610", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1311707610" }, { "id": "rs1311707610", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1311707610#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 132, "end_pos": 132, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NII->NIT).", "chr_id": "1", "chr_pos": "113093444", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I132", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O94898", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94898" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 160, "end_pos": 160, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", 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"description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": 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"https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "common_name": "Human" } ], "gene": [ { "name": "LRIG2", "url": "https://www.uniprot.org/uniprot/O94898", "locus": { "chromosome": "1", "start_pos": 113132260, "end_pos": 113073198, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000198799", "url": "https://www.ensembl.org/id/ENSG00000198799" } ] } } ], "crossref": [ { "id": "ENSG00000198799", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198799", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O94898", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94898", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd05763", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05763", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "LRIG2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=LRIG2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "9860", "url": "https://www.ncbi.nlm.nih.gov/gene/9860", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "20889", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=20889", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O94898", "url": "https://www.ebi.ac.uk/intact/interactors/id:O94898*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:9860", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9860", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "608869", "url": "http://www.omim.org/entry/608869", "database": "MIM", "categories": [ "Other" ] }, { "id": "615112", "url": "http://www.omim.org/entry/615112", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O94898", "url": "https://www.nextprot.org/entry/NX_O94898", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O94898", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94898", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "QVTMNHN", "url": "https://omabrowser.org/oma/group/QVTMNHN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5405965at2759", "url": "http://www.orthodb.org/?query=5405965at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45842:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45842:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01463", "url": "http://pfam.xfam.org/family/PF01463", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "http://pfam.xfam.org/family/PF13927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O94898", "url": "https://pharos.nih.gov/targets/O94898", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O94898", "url": "http://purl.obolibrary.org/obo/PR_O94898", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O94898-1", "url": "https://www.uniprot.org/uniprot/O94898-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESLIPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESPQLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT", "length": 1065, "header": "sp|O94898-1|LRIG2_HUMAN Isoform 1 of Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens OX=9606 GN=LRIG2 PE=1 SV=3 CANONICAL=O94898-1" }, "isoforms": [ { "isoform_ac": "O94898-1", "url": "", "sequence": { "sequence": "MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESLIPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESPQLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT", "length": 1065, "header": "sp|O94898-1|LRIG2_HUMAN Isoform 1 of Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens OX=9606 GN=LRIG2 PE=1 SV=3 CANONICAL=O94898-1" }, "locus": { "chromosome": "1", "start_pos": 113124098, "end_pos": 113073407, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000361127.6", "url": "https://www.ensembl.org/id/ENST00000361127.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000355396.4", "url": "https://www.ensembl.org/id/ENSP00000355396.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 121, "start_aa": "Asn", "end_pos": 121, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn121", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 173, "start_aa": "Asn", "end_pos": 173, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn173", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 189, "start_aa": "Asn", "end_pos": 189, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn189", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 274, "start_aa": "Asn", "end_pos": 274, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn274", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 441, "start_aa": "Asn", "end_pos": 441, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn441", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 468, "start_aa": "Asn", "end_pos": 468, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn468", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 514, "start_aa": "Asn", "end_pos": 514, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn514", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 571, "start_aa": "Asn", "end_pos": 571, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn571", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 589, "start_aa": "Asn", "end_pos": 589, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn589", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 687, "start_aa": "Asn", "end_pos": 687, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn687", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 728, "start_aa": "Asn", "end_pos": 728, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn728", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 91, "start_aa": "Asn", "end_pos": 91, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn91", "evidence": [ { "id": "O94898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94898#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O94898", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94898" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [ { "start_pos": 697, "end_pos": 697, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O94898", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94898" }, { "database": "PubMed", "id": "32387766", "url": "" } ], "site_lbl": "Ser697" }, { "start_pos": 906, "end_pos": 906, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "site_lbl": "Tyr906" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Characterization and tissue-specific expression of human LRIG2.", "journal": "Gene", "date": "2004", "authors": "Holmlund C, Nilsson J, Guo D, Starefeldt A, Golovleva I, Henriksson R, Hedman H", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" }, { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "15145052", "url": "https://glygen.org/publication/PubMed/15145052" } ] }, { "title": "Redistribution of LRIG proteins in psoriasis.", "journal": "The Journal of investigative dermatology", "date": "2008", "authors": "Karlsson T, Mark EB, Henriksson R, Hedman H", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "18037903", "url": "https://glygen.org/publication/PubMed/18037903" } ] }, { "title": "LRIG2 mutations cause urofacial syndrome.", "journal": "Am. J. Hum. Genet.", "date": "2013", "authors": "Stuart HM, Roberts NA, Burgu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson JE, Mermerkaya M, Silay MS, Lewis MA, Olondriz MB, Gener B, Beetz C, Varga RE, Gulpinar O, Suer E, Soygur T, Ozcakar ZB, Yalcinkaya F, Kavaz A, Bulum B, Gucuk A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" }, { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "23313374", "url": "https://glygen.org/publication/PubMed/23313374" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O94898", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94898" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "A SINE-VNTR-Alu in the LRIG2 Promoter Is Associated with Gene Expression at the Locus.", "journal": "International journal of molecular sciences", "date": "2020", "authors": "Hall A, Moore AK, Hernandez DG, Billingsley KJ, Bubb VJ, Quinn JP, Nabec North American Brain Expression Consortium", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "33187279", "url": "https://glygen.org/publication/PubMed/33187279" } ] }, { "title": "LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes.", "journal": "Communications biology", "date": "2021", "authors": "Herdenberg C, Mutie PM, Billing O, Abdullah A, Strawbridge RJ, Dahlman I, Tuck S, Holmlund C, Arner P, Henriksson R, Franks PW, Hedman H", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "33469151", "url": "https://glygen.org/publication/PubMed/33469151" } ] }, { "title": "Prognostic significance of LRIG2 and LRIG3 proteins in urothelial bladder carcinoma.", "journal": "Journal of immunoassay & immunochemistry", "date": "2022", "authors": "M Serag El-Dien M, Fathy Mahmoud S, Alhanafy AM, Mohamed Zanaty F, Shawky Holah N", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "34839782", "url": "https://glygen.org/publication/PubMed/34839782" } ] }, { "title": "LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.", "journal": "BMC cancer", "date": "2022", "authors": "Li ZQ, Liao WJ, Sun BL, Luo ZW, Zhong NS, Wu JB, Liu ZL, Liu JM", "evidence": [ { "database": "RefSeq", "id": "NP_001299615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001299615" } ], "reference": [ { "type": "PubMed", "id": "36183058", "url": "https://glygen.org/publication/PubMed/36183058" } ] } ], "pathway": [ { "id": "hsa:9860", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9860", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQV2-1", "protein_name": "Leucine-rich repeats and immunoglobulin-like domains 2", "gene_name": "Lrig2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAAAPRGVWEQRRLGCRLGPLAPLLMLAQALLLLPAAGAGLCPAPCSCRLPLLDCSRRKLPALSWRALSGPLSPDISSLDLSHNRLSNWNISLESETLQEVKMNYNELTEIPYFGEPTPNITQLSLVHNLIPEINAEAFQLYSALESLDLSSNIISEIKTSSFPRMSLKYLNLSNNRITTLEAGCFDNLSGSLLVVKLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTGVHKGWLYGLRMLQQLYVSQNAIEKISPDAWEFCQRLSALDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEVFSGLKSLTKLILQGNRIKSVTQKAFVGLESLEYLDLNNNAIMSIQENAFSQTHLKELVLNTSSLLCDCHLKWLLQWLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPENTVALRGVNVTLMCTAVSSSDSPMSTLWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQNSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKDEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPASGYTHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDALDQALSSLMVQMPKETFLSHPPQDAANLESLMPPTERELSAFPTNHERTSENLPFSQRSSEIFQRPLWNMNRDLGLLPFPQQPVLESPQLAERDPNCSSPVSCHRLHDHAFDFSRTRNIQDGTEGT", "length": 1054 }, "evidence": [ { "id": "45929328", "url": "http://www.informatics.jax.org/homology/45929328", "database": "MGI" }, { "id": "O94898", "url": "https://omabrowser.org/oma/group/O94898/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q52KR2-1", "protein_name": "Leucine-rich repeats and immunoglobulin-like domains protein 2", "gene_name": "Lrig2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAPRGIWEQRRLGCGLGPLARLLILAQALRLLPAARAGLCPAPCACRLPLLDCSRRKLPAPSWRALSGPLPSDISSLDLSHNRLSNWNNTLESQTLQEVKMNYNELTEIPYFGEPTPNITLLSLVHNLIPEINAEAFELYSALESLDLSSNIISEIKTSSFPRMSLKYLNLSNNRISTLEAGCFDNLSDSLLVVKLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTGVNKGWLYGLRMLQQLYMSQNAIEKISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNDISWAIEDASEAFSGLKSLTKLILQGNRIKSVTQKAFIGLESLEYLDLNNNAIMSIQENAFSQTHLKGLVLNTSSLLCDCHLKWLLQWLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPESTIALRGVNVTLTCTAVSSSDSPMSTIWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRLFSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYTHRGTDGGAGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQALSSLMVQMPKETFLSHPPQDAANLESLIPSAEREPAAFPTNHERMTENLPFSQRSSEIFQRPLWNMNRELGLLPFSQQPVLESPELTERDPNCSSPVTCRRLHDHAFDFSRTRIIQDGTEGT", "length": 1054 }, "evidence": [ { "id": "45929328", "url": "http://www.informatics.jax.org/homology/45929328", "database": "MGI" }, { "id": "O94898", "url": "https://omabrowser.org/oma/group/O94898/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "negative regulation of membrane protein ectodomain proteolysis", "id": "GO:0051045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051045", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "innervation", "id": "GO:0060384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060384", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "regulation of platelet-derived growth factor receptor signaling pathway", "id": "GO:0010640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010640", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "membrane protein ectodomain proteolysis", "id": "GO:0006509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006509", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "positive regulation of protein localization to cell surface", "id": "GO:2000010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000010", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "sensory perception of sound", "id": "GO:0007605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007605", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "protein localization to cell surface", "id": "GO:0034394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034394", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "regulation of neuron migration", "id": "GO:2001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001222", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": "negative regulation of axon regeneration", "id": "GO:0048681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048681", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "intracellular vesicle", "id": "GO:0097708", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097708", "evidence": [ { "database": "UniProtKB", "id": "O94898", "url": "https://www.uniprot.org/uniprot/O94898" } ], "pmid": "" }, { "name": 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