{ "uniprot_canonical_ac": "O94822-1", "uniprot_ac": "O94822", "uniprot_id": "LTN1_HUMAN", "mass": { "chemical_mass": 200552.0, "monoisotopic_mass": 200552.0 }, "refseq": { "ac": "NP_001307695", "name": "E3 ubiquitin-protein ligase listerin isoform 2", "summary": "Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" }, "gene_names": [ { "name": "LTN1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" }, { "name": "C21orf10; C21orf98; RNF160; ZNF294", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695", "id": "NP_001307695" }, { "name": "C21orf10", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" }, { "name": "C21orf98", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" }, { "name": "HSPC087", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" }, { "name": "KIAA0714", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" }, { "name": "LTN1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695", "id": "NP_001307695" }, { "name": "RNF160", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" }, { "name": "ZNF294", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94822", "id": "O94822" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase listerin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O94822" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94822" }, { "name": "E3 ubiquitin-protein ligase listerin isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695", "id": "NP_001307695" }, { "name": "RING finger protein 160", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94822" }, { "name": "RING-type E3 ubiquitin transferase listerin", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94822" }, { "name": "Zinc finger protein 294", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94822" }, { "name": "ring finger protein 160; zinc finger protein 294; E3 ubiquitin-protein ligase listerin; RING-type E3 ubiquitin transferase listerin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695", "id": "NP_001307695" } ], "function": [ { "annotation": "E3 ligase listerin accesses nascent polypeptides stalled at the Sec61 translocon via a gap in the ribosome-translocon junction near the Sec61 lateral gate.", "evidence": [ { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" }, { "database": "PubMed", "id": "25877867", "url": "https://glygen.org/publication/PubMed/25877867" } ] }, { "annotation": "E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822#function" }, { "database": "PubMed", "id": "25132172", "url": "https://glygen.org/publication/PubMed/25132172" }, { "database": "PubMed", "id": "23685075", "url": "https://glygen.org/publication/PubMed/23685075" }, { "database": "UniProtKB", "id": "Q04781", "url": "https://www.uniprot.org/uniprot/Q04781#function" }, { "database": "PubMed", "id": "25578875", "url": "https://glygen.org/publication/PubMed/25578875" }, { "database": "PubMed", "id": "28757607", "url": "https://glygen.org/publication/PubMed/28757607" } ] }, { "annotation": "E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.", "evidence": [ { "database": "UniProtKB", "id": "H7BYG8", "url": "https://www.uniprot.org/uniprot/H7BYG8#function" }, { "database": "UniProtKB", "id": "RU367090", "url": "https://www.uniprot.org/uniprot/RU367090#function" }, { "database": "UniProtKB", "id": "S4R3T2", "url": "https://www.uniprot.org/uniprot/S4R3T2#function" } ] }, { "annotation": "Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia.", "evidence": [ { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" }, { "database": "PubMed", "id": "34676516", "url": "https://glygen.org/publication/PubMed/34676516" } ] }, { "annotation": "Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" } ] }, { "annotation": "Results show that Listerin specificity for nascent chain-60S complexes depends on nuclear export mediator factor.", "evidence": [ { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" }, { "database": "PubMed", "id": "25578875", "url": "https://glygen.org/publication/PubMed/25578875" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1601180051", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1601180051" }, { "id": "rs1601180051", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1601180051" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1100, "end_pos": 1100, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIS->NIS).", "chr_id": "21", "chr_pos": "28952205", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1100", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O94822", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94822" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1164, "end_pos": 1164, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "G", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NGG->NGS).", "chr_id": "21", "chr_pos": "28946285", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "G1164", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "O94822", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94822" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1300, "end_pos": 1300, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "P", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NLP->NLS).", "chr_id": "21", "chr_pos": "28944467", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "P1300", "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Distal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of Proximal Third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, somatic", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophageal tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant esophagus tumor", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus neoplasm", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant oesophagus tumour", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of middle third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant neoplasm of upper third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of distal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of proximal third of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumor of the middle third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of abdominal oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of distal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of proximal third of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the middle third of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Aerodigestive tract cancer, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Escc, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal squamous cell carcinoma, susceptibility to", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1181843384", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1181843384" }, { "id": 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"MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKECTCREVQILTSVWKKILFLSSDWKFLASVCCLRFHDSLASSSPYS", "length": 767, "header": "tr|H7BYG8-1|H7BYG8_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=2 CANONICAL=O94822-1" }, "locus": { "chromosome": "21", "start_pos": 28992805, "end_pos": 28964629, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000389195.7", "url": "https://www.ensembl.org/id/ENST00000389195.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000373847.3", "url": "https://www.ensembl.org/id/ENSP00000373847.3" } ] } }, { "isoform_ac": "O94822-1", "url": "", "sequence": { "sequence": "MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQHVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLMPSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSALWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQSLPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLENNELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNRSREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKKEFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEHEDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSENQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLLPILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQTLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMSLLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF", "length": 1766, "header": "sp|O94822-1|LTN1_HUMAN Isoform 1 of E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6 CANONICAL=O94822-1" }, "locus": { "chromosome": "21", "start_pos": 28992805, "end_pos": 28930451, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000361371.10", "url": "https://www.ensembl.org/id/ENST00000361371.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000354977.4", "url": "https://www.ensembl.org/id/ENSP00000354977.4" } ] } }, { "isoform_ac": "O94822-2", "url": "", "sequence": { "sequence": "MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQ", "length": 437, "header": "sp|O94822-2|LTN1_HUMAN Isoform 2 of E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6 CANONICAL=O94822-1" }, "locus": {} }, { "isoform_ac": "O94822-3", "url": "", "sequence": { "sequence": "MDRVGGGKGPGGSYYRVSSSAARSRKLCPGRVNRGLSAQSTAATATMGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQHVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLMPSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSALWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQSLPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLENNELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNRSREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKKEFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEHEDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSENQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLLPILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQTLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMSLLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF", "length": 1812, "header": "sp|O94822-3|LTN1_HUMAN Isoform 3 of E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6 CANONICAL=O94822-1" }, "locus": { "chromosome": "HG2219_PATCH", "start_pos": 83677, "end_pos": 21185, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000707899.1", "url": "https://www.ensembl.org/id/ENST00000707899.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000517025.1", "url": "https://www.ensembl.org/id/ENSP00000517025.1" } ] } }, { "isoform_ac": "S4R3T2-1", "url": "", "sequence": { "sequence": "XSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQ", "length": 366, "header": "tr|S4R3T2-1|S4R3T2_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=1 CANONICAL=O94822-1" }, "locus": { "chromosome": "21", "start_pos": 28986761, "end_pos": 28969466, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000483326.1", "url": "https://www.ensembl.org/id/ENST00000483326.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000474690.1", "url": "https://www.ensembl.org/id/ENSP00000474690.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1336, "start_aa": "Thr", "end_pos": 1336, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1336", "evidence": [ { "id": "O94822", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94822" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O94822", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O94822" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1337, "start_aa": "Ser", "end_pos": 1337, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1337", "evidence": [ { "id": "O94822", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94822" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O94822", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O94822" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 706, "start_aa": "Thr", "end_pos": 706, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr706", "evidence": [ { "id": "O94822", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94822" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "O94822", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O94822" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 706, "start_aa": "Thr", "end_pos": 706, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr706", "evidence": [ { "id": "GLY_000142", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000142" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" } ] } ], "phosphorylation": [ { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O94822", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94822" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser18" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Two new proteases in the MHC class I processing pathway.", "journal": "Nature immunology", "date": "2000", "authors": "Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11062501", "url": "https://glygen.org/publication/PubMed/11062501" } ] }, { "title": "26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.", "journal": "The EMBO journal", "date": "2001", "authors": "Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11350924", "url": "https://glygen.org/publication/PubMed/11350924" } ] }, { "title": "U-box proteins as a new family of ubiquitin ligases.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hatakeyama S, Nakayama KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "12646216", "url": "https://glygen.org/publication/PubMed/12646216" } ] }, { "title": "Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.", "journal": "Current opinion in immunology", "date": "2004", "authors": "Kloetzel PM, Ossendorp F", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "14734113", "url": "https://glygen.org/publication/PubMed/14734113" } ] }, { "title": "Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.", "journal": "Nature immunology", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224091", "url": "https://glygen.org/publication/PubMed/15224091" } ] }, { "title": "Post-proteasomal antigen processing for major histocompatibility complex class I presentation.", "journal": "Nature immunology", "date": "2004", "authors": "Rock KL, York IA, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224092", "url": "https://glygen.org/publication/PubMed/15224092" } ] }, { "title": "The proteasome and MHC class I antigen processing.", "journal": "Biochimica et biophysica acta", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15571818", "url": "https://glygen.org/publication/PubMed/15571818" } ] }, { "title": "Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Tokgoz Z, Bohnsack RN, Haas AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16595681", "url": "https://glygen.org/publication/PubMed/16595681" } ] }, { "title": "Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2006", "authors": "York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16849449", "url": "https://glygen.org/publication/PubMed/16849449" } ] }, { "title": "A novel family of membrane-bound E3 ubiquitin ligases.", "journal": "Journal of biochemistry", "date": "2006", "authors": "Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16954532", "url": "https://glygen.org/publication/PubMed/16954532" } ] }, { "title": "Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.", "journal": "Cell", "date": "2008", "authors": "Lee I, Schindelin H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "18662542", "url": "https://glygen.org/publication/PubMed/18662542" } ] }, { "title": "Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.", "journal": "The international journal of biochemistry & cell biology", "date": "2009", "authors": "Ebstein F, Lange N, Urban S, Seifert U, Kruger E, Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19028597", "url": "https://glygen.org/publication/PubMed/19028597" } ] }, { "title": "Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.", "journal": "Nature reviews. Molecular cell biology", "date": "2009", "authors": "Schulman BA, Harper JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19352404", "url": "https://glygen.org/publication/PubMed/19352404" } ] }, { "title": "What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?", "journal": "Journal of molecular evolution", "date": "2009", "authors": "Michelle C, Vourc'h P, Mignon L, Andres CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19452197", "url": "https://glygen.org/publication/PubMed/19452197" } ] }, { "title": "RING domain E3 ubiquitin ligases.", "journal": "Annual review of biochemistry", "date": "2009", "authors": "Deshaies RJ, Joazeiro CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19489725", "url": "https://glygen.org/publication/PubMed/19489725" } ] }, { "title": "Building ubiquitin chains: E2 enzymes at work.", "journal": "Nature reviews. Molecular cell biology", "date": "2009", "authors": "Ye Y, Rape M", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19851334", "url": "https://glygen.org/publication/PubMed/19851334" } ] }, { "title": "Mechanisms of ubiquitin transfer by the anaphase-promoting complex.", "journal": "Journal of biology", "date": "2009", "authors": "Matyskiela ME, Rodrigo-Brenni MC, Morgan DO", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19874575", "url": "https://glygen.org/publication/PubMed/19874575" } ] }, { "title": "The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2010", "authors": "van Wijk SJ, Timmers HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19940261", "url": "https://glygen.org/publication/PubMed/19940261" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O94822-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94822-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.", "journal": "Biochemistry", "date": "1990", "authors": "Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "2261476", "url": "https://glygen.org/publication/PubMed/2261476" } ] }, { "title": "Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation.", "journal": "Molecular cell", "date": "2013-06-06", "authors": "Shao Sichen, von der Malsburg Karina, Hegde Ramanujan S", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "reference": [ { "type": "PubMed", "id": "23685075", "url": "https://glygen.org/publication/PubMed/23685075" } ] }, { "title": "Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.", "journal": "Molecular cell", "date": "2014-09-18", "authors": "Shao Sichen, Hegde Ramanujan S", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "reference": [ { "type": "PubMed", "id": "25132172", "url": "https://glygen.org/publication/PubMed/25132172" } ] }, { "title": "Structure and assembly pathway of the ribosome quality control complex.", "journal": "Molecular cell", "date": "2015", "authors": "Shao S, Brown A, Santhanam B, Hegde RS", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" }, { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" } ], "reference": [ { "type": "PubMed", "id": "25578875", "url": "https://glygen.org/publication/PubMed/25578875" } ] }, { "title": "The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.", "journal": "Molecular biology of the cell", "date": "2015", "authors": "von der Malsburg K, Shao S, Hegde RS", "evidence": [ { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" } ], "reference": [ { "type": "PubMed", "id": "25877867", "url": "https://glygen.org/publication/PubMed/25877867" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O94822", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94822" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Ubiquitination of stalled ribosome triggers ribosome-associated quality control.", "journal": "Nature communications", "date": "2017", "authors": "Matsuo Y, Ikeuchi K, Saeki Y, Iwasaki S, Schmidt C, Udagawa T, Sato F, Tsuchiya H, Becker T, Tanaka K, Ingolia NT, Beckmann R, Inada T", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "reference": [ { "type": "PubMed", "id": "28757607", "url": "https://glygen.org/publication/PubMed/28757607" } ] }, { "title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).", "journal": "Molecular & cellular proteomics : MCP", "date": "2018", "authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O94822", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94822" }, { "database": "O-GlcNAc Atlas", "id": "O94822", "url": "https://oglcnac.org/atlas/detail/O94822" }, { "database": "GlyGen", "id": "GLY_000142", "url": "https://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "Expression Analysis of Ermin and Listerin E3 Ubiquitin Protein Ligase 1 Genes in the Periphery of Patients with Schizophrenia.", "journal": "Journal of molecular neuroscience : MN", "date": "2022", "authors": "Farhang S, Sabaie H, Gharesouran J, Asadi MR, Arsang-Jang S, Ghafouri-Fard S, Taheri M, Rezazadeh M", "evidence": [ { "database": "RefSeq", "id": "NP_001307695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307695" } ], "reference": [ { "type": "PubMed", "id": "34676516", "url": "https://glygen.org/publication/PubMed/34676516" } ] }, { "title": "Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1997", "authors": "Craiu A, Akopian T, Goldberg A, Rock KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": 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"length": 1747 }, "evidence": [ { "id": "O94822", "url": "https://omabrowser.org/oma/group/O94822/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "ribosome-associated ubiquitin-dependent protein catabolic process", "id": "GO:1990116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990116", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "protein autoubiquitination", "id": "GO:0051865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051865", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "RQC complex", "id": "GO:1990112", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990112", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "ribosomal large subunit binding", "id": "GO:0043023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043023", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "O94822", "url": "https://www.uniprot.org/uniprot/O94822" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1058, "end_pos": 1060, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1069, "end_pos": 1071, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1079, "end_pos": 1081, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1209, "end_pos": 1211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1584, "end_pos": 1586, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1691, "end_pos": 1693, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1726, "end_pos": 1728, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1754, "end_pos": 1756, "annotation": "n_glycosylation_sequon" }, { "start_pos": 577, "end_pos": 579, "annotation": "n_glycosylation_sequon" }, { "start_pos": 950, "end_pos": 952, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-HSA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983140" } ] }, { "id": "R-HSA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O95376-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9Y508-1", "Q6ZNA4-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P46934-1", "Q14139-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1" ], "evidence": [ { "id": "R-HSA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983147" } ] }, { "id": "R-HSA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983156" } ] }, { "id": "R-HSA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00762", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] } ] }, { "uniprot_ac": "O14933", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14933" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14933" } ] } ] }, { "uniprot_ac": "O15033", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15033" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15033" } ] } ] }, { "uniprot_ac": "O43164", "gene_name": "PJA2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43164" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43164" } ] } ] }, { "uniprot_ac": "O43255", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43255" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43255" } ] } ] }, { "uniprot_ac": "O60260", "gene_name": "PRKN", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] }, { "ec_number": "6.3.2.19", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] } ] }, { "uniprot_ac": "O60291", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60291" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60291" } ] } ] }, { "uniprot_ac": "O94822", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94822" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94822" } ] } ] }, { "uniprot_ac": "O94874", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "O94874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94874" } ] } ] }, { "uniprot_ac": "O94941", "gene_name": "UBOX5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94941" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94941" } ] } ] }, { "uniprot_ac": "O94972", "gene_name": "TRIM37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94972" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94972" } ] } ] }, { "uniprot_ac": "O95376", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95376" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95376" } ] } ] }, { "uniprot_ac": "O95714", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95714" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95714" } ] } ] }, { "uniprot_ac": "P19474", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19474" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19474" } ] } ] }, { "uniprot_ac": "P41226", "gene_name": "UBA7", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P41226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41226" } ] } ] }, { "uniprot_ac": "P46934", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46934" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46934" } ] } ] }, { "uniprot_ac": "P49427", "gene_name": "CDC34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] } ] }, { "uniprot_ac": "P49459", "gene_name": "UBE2A", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49459" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49459" } ] } ] }, { "uniprot_ac": "P51668", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] } ] }, { "uniprot_ac": "P51965", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] } ] }, { "uniprot_ac": "P60604", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60604" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60604" } ] } ] }, { "uniprot_ac": "P61077", "gene_name": "UBE2D3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] } ] }, { "uniprot_ac": "P61081", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61081" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61081" } ] } ] }, { "uniprot_ac": "P61086", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61086" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61086" } ] } ] }, { "uniprot_ac": "P61088", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61088" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61088" } ] } ] }, { "uniprot_ac": "P62253", "gene_name": "UBE2G1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62253" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62253" } ] } ] }, { "uniprot_ac": "P62256", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] }, { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] } ] }, { "uniprot_ac": "P62837", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] } ] }, { "uniprot_ac": "P62877", "gene_name": "RBX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] } ] }, { "uniprot_ac": "P63146", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63146" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63146" } ] } ] }, { "uniprot_ac": "P68036", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68036" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68036" } ] } ] }, { "uniprot_ac": "P78317", "gene_name": "RNF4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78317" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78317" } ] } ] }, { "uniprot_ac": "Q05086", "gene_name": "UBE3A", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05086" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05086" } ] } ] }, { "uniprot_ac": "Q13049", "gene_name": "TRIM32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13049" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13049" } ] } ] }, { "uniprot_ac": "Q13191", "gene_name": "CBLB", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13191" } ] } ] }, { "uniprot_ac": "Q14139", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14139" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14139" } ] } ] }, { "uniprot_ac": "Q14669", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14669" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14669" } ] } ] }, { "uniprot_ac": "Q15034", "gene_name": "HERC3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15034" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15034" } ] } ] }, { "uniprot_ac": "Q15386", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15386" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15386" } ] } ] }, { "uniprot_ac": "Q15751", "gene_name": "HERC1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15751" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15751" } ] } ] }, { "uniprot_ac": "Q16763", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] } ] }, { "uniprot_ac": "Q2Q1W2", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2Q1W2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2Q1W2" } ] } ] }, { "uniprot_ac": "Q5GLZ8", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GLZ8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GLZ8" } ] } ] }, { "uniprot_ac": "Q5T447", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T447" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T447" } ] } ] }, { "uniprot_ac": "Q5T4S7", "gene_name": "UBR4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T4S7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T4S7" } ] } ] }, { "uniprot_ac": "Q5U5Q3", "gene_name": "MEX3C", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5Q3" } ] } ] }, { "uniprot_ac": "Q5U5R9", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5R9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5R9" } ] } ] }, { "uniprot_ac": "Q5VTB9", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VTB9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VTB9" } ] } ] }, { "uniprot_ac": "Q5VVX9", "gene_name": "UBE2U", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VVX9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VVX9" } ] } ] }, { "uniprot_ac": "Q5XPI4", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI4" } ] } ] }, { "uniprot_ac": "Q63HN8", "gene_name": "RNF213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] } ] }, { "uniprot_ac": "Q6Q0C0", "gene_name": "TRAF7", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] } ] }, { "uniprot_ac": "Q6UWE0", "gene_name": "LRSAM1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWE0" } ] } ] }, { "uniprot_ac": "Q6ZMZ0", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMZ0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMZ0" } ] } ] }, { "uniprot_ac": "Q6ZNA4", "gene_name": "RNF111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZNA4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZNA4" } ] } ] }, { "uniprot_ac": "Q712K3", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q712K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q712K3" } ] } ] }, { "uniprot_ac": "Q7Z3V4", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3V4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3V4" } ] } ] }, { "uniprot_ac": "Q7Z419", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z419" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z419" } ] } ] }, { "uniprot_ac": "Q7Z6E9", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6E9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6E9" } ] } ] }, { "uniprot_ac": "Q7Z6J0", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J0" } ] } ] }, { "uniprot_ac": "Q7Z6J8", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J8" } ] } ] }, { "uniprot_ac": "Q7Z6Z7", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z7" } ] } ] }, { "uniprot_ac": "Q7Z7E8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z7E8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z7E8" } ] } ] }, { "uniprot_ac": "Q86WT6", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WT6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WT6" } ] } ] }, { "uniprot_ac": "Q86XS8", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XS8" } ] } ] }, { "uniprot_ac": "Q86XT4", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XT4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XT4" } ] } ] }, { "uniprot_ac": "Q86Y13", "gene_name": "DZIP3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y13" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y13" } ] } ] }, { "uniprot_ac": "Q8IUQ4", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUQ4" } ] } ] }, { "uniprot_ac": "Q8IVU3", "gene_name": "HERC6", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IVU3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IVU3" } ] } ] }, { "uniprot_ac": "Q8IWV7", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV7" } ] } ] }, { "uniprot_ac": "Q8IWV8", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV8" } ] } ] }, { "uniprot_ac": "Q8IYU2", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IYU2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IYU2" } ] } ] }, { "uniprot_ac": "Q8N2K1", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K1" } ] } ] }, { "uniprot_ac": "Q8N6D2", "gene_name": "RNF182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6D2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6D2" } ] } ] }, { "uniprot_ac": "Q8N7E2", "gene_name": "CBLL2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N7E2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N7E2" } ] } ] }, { "uniprot_ac": "Q8ND25", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ND25" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ND25" } ] } ] }, { "uniprot_ac": "Q8NG27", "gene_name": "PJA1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG27" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG27" } ] } ] }, { "uniprot_ac": "Q8NHG8", "gene_name": "ZNRF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHG8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHG8" } ] } ] }, { "uniprot_ac": "Q8TBB1", "gene_name": "LNX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBB1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBB1" } ] } ] }, { "uniprot_ac": "Q8TC41", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC41" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC41" } ] } ] }, { "uniprot_ac": "Q8TDB6", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDB6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDB6" } ] } ] }, { "uniprot_ac": "Q8WV44", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WV44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WV44" } ] } ] }, { "uniprot_ac": "Q8WVD3", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVD3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVD3" } ] } ] }, { "uniprot_ac": "Q8WVN8", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVN8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVN8" } ] } ] }, { "uniprot_ac": "Q8WY64", "gene_name": "MYLIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY64" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY64" } ] } ] }, { "uniprot_ac": "Q969K3", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969K3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969K3" } ] } ] }, { "uniprot_ac": "Q969M7", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969M7" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969M7" } ] } ] }, { "uniprot_ac": "Q969Q1", "gene_name": "TRIM63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969Q1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969Q1" } ] } ] }, { "uniprot_ac": "Q969T4", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969T4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969T4" } ] } ] }, { "uniprot_ac": "Q96AX9", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AX9" } ] } ] }, { "uniprot_ac": "Q96B02", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.25", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] } ] }, { "uniprot_ac": "Q96BH1", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BH1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BH1" } ] } ] }, { "uniprot_ac": "Q96F44", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96F44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96F44" } ] } ] }, { "uniprot_ac": "Q96J02", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J02" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J02" } ] } ] }, { "uniprot_ac": "Q96LR5", "gene_name": "UBE2E2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LR5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LR5" } ] } ] }, { "uniprot_ac": "Q96PM5", "gene_name": "RCHY1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PM5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PM5" } ] } ] }, { "uniprot_ac": "Q96PU5", "gene_name": "NEDD4L", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] } ] }, { "uniprot_ac": "Q9BV68", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV68" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV68" } ] } ] }, { "uniprot_ac": "Q9BWF2", "gene_name": "TRAIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWF2" } ] } ] }, { "uniprot_ac": "Q9BYM8", "gene_name": "RBCK1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYM8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYM8" } ] } ] }, { "uniprot_ac": "Q9C026", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C026" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C026" } ] } ] }, { "uniprot_ac": "Q9C037", "gene_name": "TRIM4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C037" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C037" } ] } ] }, { "uniprot_ac": "Q9C0C9", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C0C9" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C0C9" } ] } ] }, { "uniprot_ac": "Q9H0M0", "gene_name": "WWP1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0M0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0M0" } ] } ] }, { "uniprot_ac": "Q9H4P4", "gene_name": "RNF41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4P4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4P4" } ] } ] }, { "uniprot_ac": "Q9H832", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H832" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H832" } ] } ] }, { "uniprot_ac": "Q9H9P5", "gene_name": "UNKL", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9H9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H9P5" } ] } ] }, { "uniprot_ac": "Q9HAU4", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAU4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAU4" } ] } ] }, { "uniprot_ac": "Q9HCE7", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCE7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCE7" } ] } ] }, { "uniprot_ac": "Q9HCM9", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCM9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCM9" } ] } ] }, { "uniprot_ac": "Q9NQ86", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQ86" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQ86" } ] } ] }, { "uniprot_ac": "Q9NV58", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV58" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV58" } ] } ] }, { "uniprot_ac": "Q9NVW2", "gene_name": "RLIM", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVW2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVW2" } ] } ] }, { "uniprot_ac": "Q9P2P5", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P2P5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P2P5" } ] } ] }, { "uniprot_ac": "Q9UBS8", "gene_name": "RNF14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBS8" } ] } ] }, { "uniprot_ac": "Q9UHC7", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHC7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHC7" } ] } ] }, { "uniprot_ac": "Q9UII4", "gene_name": "HERC5", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9UII4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UII4" } ] } ] }, { "uniprot_ac": "Q9ULT8", "gene_name": "HECTD1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULT8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULT8" } ] } ] }, { "uniprot_ac": "Q9UNE7", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNE7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNE7" } ] } ] }, { "uniprot_ac": "Q9Y252", "gene_name": "RNF6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y252" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y252" } ] } ] }, { "uniprot_ac": "Q9Y2X8", "gene_name": "UBE2D4", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2X8" } ] } ] }, { "uniprot_ac": "Q9Y385", "gene_name": "UBE2J1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y385" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y385" } ] } ] }, { "uniprot_ac": "Q9Y4B6", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4B6" } ] } ] }, { "uniprot_ac": "Q9Y4L5", "gene_name": "RNF115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4L5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4L5" } ] } ] }, { "uniprot_ac": "Q9Y508", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 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