{ "uniprot_canonical_ac": "O94811-1", "uniprot_ac": "O94811", "uniprot_id": "TPPP_HUMAN", "mass": { "chemical_mass": 23694.0, "monoisotopic_mass": 23694.0 }, "refseq": { "ac": "NP_008961", "name": "tubulin polymerization-promoting protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" }, "gene_names": [ { "name": "TPPP", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O94811", "id": "O94811" }, { "name": "TPPP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O94811", "id": "O94811" }, { "name": "TPPP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961", "id": "NP_008961" }, { "name": "p24; p25; p25alpha; TPPP/p25; TPPP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961", "id": "NP_008961" } ], "protein_names": [ { "name": "Tubulin polymerization-promoting protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O94811" }, { "name": "25 kDa brain-specific protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94811" }, { "name": "3.6.5.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94811" }, { "name": "TPPP/p25", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94811" }, { "name": "TPPP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94811" }, { "name": "glycogen synthase kinase 3 (GSK3) inhibitor p24; brain specific protein p25 alpha; p25-alpha; 25 kDa brain-specific protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961", "id": "NP_008961" }, { "name": "p24", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94811" }, { "name": "p25-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O94811" }, { "name": "tubulin polymerization-promoting protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961", "id": "NP_008961" } ], "function": [ { "annotation": "Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" }, { "database": "PubMed", "id": "34831132", "url": "https://glygen.org/publication/PubMed/34831132" } ] }, { "annotation": "HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" }, { "database": "PubMed", "id": "35062349", "url": "https://glygen.org/publication/PubMed/35062349" } ] }, { "annotation": "Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21995432, PubMed:21316364). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514).", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811#function" }, { "database": "PubMed", "id": "17105200", "url": "https://glygen.org/publication/PubMed/17105200" }, { "database": "PubMed", "id": "18028908", "url": "https://glygen.org/publication/PubMed/18028908" }, { "database": "PubMed", "id": "20308065", "url": "https://glygen.org/publication/PubMed/20308065" }, { "database": "PubMed", "id": "26289831", "url": "https://glygen.org/publication/PubMed/26289831" }, { "database": "PubMed", "id": "17693641", "url": "https://glygen.org/publication/PubMed/17693641" }, { "database": "PubMed", "id": "22328514", "url": "https://glygen.org/publication/PubMed/22328514" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" }, { "database": "PubMed", "id": "21995432", "url": "https://glygen.org/publication/PubMed/21995432" }, { "database": "PubMed", "id": "21316364", "url": "https://glygen.org/publication/PubMed/21316364" }, { "database": "PubMed", "id": "31522887", "url": "https://glygen.org/publication/PubMed/31522887" } ] }, { "annotation": "TPPP/p25 has a role in stabilization of physiological microtubular ultrastructures and cell survival", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" }, { "database": "PubMed", "id": "15564385", "url": "https://glygen.org/publication/PubMed/15564385" } ] }, { "annotation": "This study revealed the low expression level of TPPP in pancreatic cancer cells. In addition, the high expression of TPPP promotes the invasion, migration and angiogenesis of pancreatic cancer cells.", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" }, { "database": "PubMed", "id": "31631174", "url": "https://glygen.org/publication/PubMed/31631174" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1266187364", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1266187364" }, { "id": "rs1266187364", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1266187364" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 155, "end_pos": 155, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "5", "chr_pos": "665972", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T155", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs142128231", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142128231" }, { "id": "rs142128231", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142128231" }, { "id": "rs142128231", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs142128231#frequency_tab" }, { "id": "rs142128231", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs142128231" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 155, "end_pos": 155, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->M).", "chr_id": "5", "chr_pos": "665971", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T155", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs142128231", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142128231" }, { "id": "rs142128231", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142128231" }, { "id": "rs142128231", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs142128231#frequency_tab" }, { "id": "rs142128231", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs142128231" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 155, "end_pos": 155, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->R).", "chr_id": "5", "chr_pos": "665971", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T155", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O94811", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O94811" }, { "id": "rs1335924594", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1335924594" }, { "id": "rs1335924594", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1335924594" }, { "id": "rs1335924594", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1335924594" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 159, "end_pos": 159, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "L", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->L).", "chr_id": "5", "chr_pos": "665286", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "S159", "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs762357148", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762357148" }, { "id": "rs762357148", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs762357148" }, { "id": "rs762357148", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs762357148" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 92, "end_pos": 92, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TVT->NVT).", "chr_id": "5", "chr_pos": "677786", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T92", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 107, "end_pos": 107, "sequence_org": "S", "sequence_mut": "A", "comment": "In 3Ala; abolished phosphorylation by ROCK1, leading to delayed entry into S-phase; when associated with A-32 and A-159.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 107, "end_pos": 107, "sequence_org": "S", "sequence_mut": "E", "comment": "In 3Glu; phosphomimetic mutant, leading to decreased transition of the G1/S-phase; when associated with E-32 and E-159.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 14, "end_pos": 14, "sequence_org": "T", "sequence_mut": "A", "comment": "In 4Ala; abolished phosphorylation by CDK1 without affecting G1/S-phase transition; when associated with A-18, A-45 and A-160.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 14, "end_pos": 14, "sequence_org": "T", "sequence_mut": "E", "comment": "In 4Glu; phosphomimetic mutant, does not affect G1/S-phase transition; when associated with E-18, E-45 and E-160.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 159, "end_pos": 159, "sequence_org": "S", "sequence_mut": "A", "comment": "In 3Ala; abolished phosphorylation by ROCK1, leading to delayed entry into S-phase; when associated with A-32 and A-107.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 159, "end_pos": 159, "sequence_org": "S", "sequence_mut": "E", "comment": "In 3Glu; phosphomimetic mutant, leading to decreased transition of the G1/S-phase; when associated with E-32 and E-107.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 160, "end_pos": 160, "sequence_org": "S", "sequence_mut": "A", "comment": "In 4Ala; abolished phosphorylation by CDK1 without affecting G1/S-phase transition; when associated with A-14, A-18 and A-45.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 160, "end_pos": 160, "sequence_org": "S", "sequence_mut": "E", "comment": "In 4Glu; phosphomimetic mutant, does not affect G1/S-phase transition; when associated with E-14, E-18 and E-45.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 18, "end_pos": 18, "sequence_org": "S", "sequence_mut": "A", "comment": "In 4Ala; abolished phosphorylation by CDK1 without affecting G1/S-phase transition; when associated with A-14, A-45 and A-160.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 18, "end_pos": 18, "sequence_org": "S", "sequence_mut": "E", "comment": "In 4Glu; phosphomimetic mutant, does not affect G1/S-phase transition; when associated with E-14, E-45 and E-160.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 32, "end_pos": 32, "sequence_org": "S", "sequence_mut": "A", "comment": "In 3Ala; abolished phosphorylation by ROCK1, leading to delayed entry into S-phase; when associated with A-107 and A-159.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "start_pos": 32, "end_pos": 32, "sequence_org": "S", "sequence_mut": "E", "comment": "In 3Glu; phosphomimetic mutant, leading to decreased transition of the G1/S-phase; when associated with E-07 and E-159.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O94811", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O94811" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O94811", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O94811" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O94811" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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Hum. Genet.", "date": "1999", "authors": "Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "10083737", "url": "https://glygen.org/publication/PubMed/10083737" } ] }, { "title": "Dynamic targeting of microtubules by TPPP/p25 affects cell survival.", "journal": "Journal of cell science", "date": "2004", "authors": "Lehotzky A, Tirian L, Tokesi N, Lenart P, Szabo B, Kovacs J, Ovadi J", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" } ], "reference": [ { "type": "PubMed", "id": "15564385", "url": "https://glygen.org/publication/PubMed/15564385" } ] }, { "title": "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Lindersson Evo, Lundvig Ditte, Petersen Christine, Madsen Peder, Nyengaard Jens R, H\u00f8jrup Peter, Moos Torben, Otzen Daniel, Gai Wei-Ping, Blumbergs Peter C, Jensen Poul Henning", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "15590652", "url": "https://glygen.org/publication/PubMed/15590652" } ] }, { "title": "Phosphoproteomic analysis of synaptosomes from human cerebral cortex.", "journal": "Journal of proteome research", "date": "2005", "authors": "DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG Jr, Leite JP, Pant HC, Dosemeci A", "evidence": [ { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "15822905", "url": "https://glygen.org/publication/PubMed/15822905" } ] }, { "title": "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.", "journal": "FEBS Lett.", "date": "2006", "authors": "Ol\u00e1h Judit, Tok\u00e9si Nat\u00e1lia, Vincze Orsolya, Horv\u00e1th Istv\u00e1n, Lehotzky Attila, Erdei Anna, Sz\u00e1jli Em\u00edlia, Medzihradszky Katalin F, Orosz Ferenc, Kov\u00e1cs G\u00e1bor G, Ov\u00e1di Judit", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "17027006", "url": "https://glygen.org/publication/PubMed/17027006" } ] }, { "title": "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.", "journal": "Biochemistry", "date": "2006", "authors": "Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "17105200", "url": "https://glygen.org/publication/PubMed/17105200" } ] }, { "title": "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Hlavanda E, Klement E, Kokai E, Kovacs J, Vincze O, Tokesi N, Orosz F, Medzihradszky KF, Dombradi V, Ovadi J", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "17693641", "url": "https://glygen.org/publication/PubMed/17693641" } ] }, { "title": "The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.", "journal": "Experimental cell research", "date": "2007", "authors": "Acevedo K, Li R, Soo P, Suryadinata R, Sarcevic B, Valova VA, Graham ME, Robinson PJ, Bernard O", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "18028908", "url": "https://glygen.org/publication/PubMed/18028908" } ] }, { "title": "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.", "journal": "Journal of proteome research", "date": "2008", "authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.", "journal": "The Journal of biological chemistry", "date": "2010-06-04", "authors": "Tok\u00e9si Nat\u00e1lia, Lehotzky Attila, Horv\u00e1th Istv\u00e1n, Szab\u00f3 B\u00e1lint, Ol\u00e1h Judit, Lau Pierre, Ov\u00e1di Judit", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "20308065", "url": "https://glygen.org/publication/PubMed/20308065" } ] }, { "title": "Human Alzheimer's disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry.", "journal": "Amino acids", "date": "2011", "authors": "Skorobogatko YV, Deuso J, Adolf-Bryfogle J, Nowak MG, Gong Y, Lippa CF, Vosseller K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O94811", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94811" } ], "reference": [ { "type": "PubMed", "id": "20563614", "url": "https://glygen.org/publication/PubMed/20563614" } ] }, { "title": "Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity.", "journal": "FEBS letters", "date": "2011-03-09", "authors": "Zotter Agnes, Bodor Andrea, Ol\u00e1h Judit, Hlavanda Emma, Orosz Ferenc, Perczel Andr\u00e1s, Ov\u00e1di Judit", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "21316364", "url": "https://glygen.org/publication/PubMed/21316364" } ] }, { "title": "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2011", "authors": "Vincze Orsolya, Ol\u00e1h Judit, Z\u00e1dori D\u00e9nes, Kliv\u00e9nyi P\u00e9ter, V\u00e9csei L\u00e1szl\u00f3, Ov\u00e1di Judit", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "21565174", "url": "https://glygen.org/publication/PubMed/21565174" } ] }, { "title": "Zn(2)+-induced rearrangement of the disordered TPPP/p25 affects its microtubule assembly and GTPase activity.", "journal": "Biochemistry", "date": "2011", "authors": "Zotter A, Olah J, Hlavanda E, Bodor A, Perczel A, Szigeti K, Fidy J, Ovadi J", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "21995432", "url": "https://glygen.org/publication/PubMed/21995432" } ] }, { "title": "TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.", "journal": "Journal of cell science", "date": "2012", "authors": "Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "22328514", "url": "https://glygen.org/publication/PubMed/22328514" } ] }, { "title": "Microtubule assembly-derived by dimerization of TPPP/p25. Evaluation of thermodynamic parameters for multiple equilibrium system from ITC data.", "journal": "Biochim. Biophys. Acta", "date": "2012", "authors": "Ol\u00e1h Judit, Zotter \u00c1gnes, Hlavanda Emma, Szunyogh S\u00e1ndor, Orosz Ferenc, Szigeti Kriszti\u00e1n, Fidy Judit, Ov\u00e1di Judit", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "22484033", "url": "https://glygen.org/publication/PubMed/22484033" } ] }, { "title": "Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Schofield AV, Steel R, Bernard O", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" } ] }, { "title": "Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Schofield AV, Gamell C, Suryadinata R, Sarcevic B, Bernard O", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "iPTMnet", "id": "O94811", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O94811" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.", "journal": "Biochimica et biophysica acta", "date": "2015", "authors": "Lehotzky A, Olah J, Szunyogh S, Szabo A, Berki T, Ovadi J", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "25445539", "url": "https://glygen.org/publication/PubMed/25445539" } ] }, { "title": "Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.", "journal": "Scientific reports", "date": "2015-08-20", "authors": "DeBonis Salvatore, Neumann Emmanuelle, Skoufias Dimitrios A", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "26289831", "url": "https://glygen.org/publication/PubMed/26289831" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "O94811", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94811" }, { "database": "O-GlcNAc Atlas", "id": "O94811", "url": "https://oglcnac.org/atlas/detail/O94811" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "O94811", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O94811" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "Interactions between two regulatory proteins of microtubule dynamics, HDAC6, TPPP/p25, and the hub protein, DYNLL/LC8.", "journal": "Biochim. Biophys. Acta", "date": "2019", "authors": "Olah J, Szunyogh S, Szenasi T, Szaniszlo T, Szabo A, Lehotzky A, Berki T, Nyitray L, Ovadi J", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "31505170", "url": "https://glygen.org/publication/PubMed/31505170" } ] }, { "title": "The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination.", "journal": "Cell", "date": "2019", "authors": "Fu MM, McAlear TS, Nguyen H, Oses-Prieto JA, Valenzuela A, Shi RD, Perrino JJ, Huang TT, Burlingame AL, Bechstedt S, Barres BA", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "31522887", "url": "https://glygen.org/publication/PubMed/31522887" } ] }, { "title": "YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways.", "journal": "British journal of cancer", "date": "2019", "authors": "Chen Q, Yang C, Chen L, Zhang JJ, Ge WL, Yuan H, Meng LD, Huang XM, Shen P, Miao Y, Jiang KR", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" } ], "reference": [ { "type": "PubMed", "id": "31631174", "url": "https://glygen.org/publication/PubMed/31631174" } ] }, { "title": "Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins.", "journal": "Cell Calcium", "date": "2021", "authors": "Doi Seita, Fujioka Naoki, Ohtsuka Satomi, Kondo Rina, Yamamoto Maho, Denda Miwako, Magari Masaki, Kanayama Naoki, Hatano Naoya, Morishita Ryo, Hasegawa Takafumi, Tokumitsu Hiroshi", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "reference": [ { "type": "PubMed", "id": "33831707", "url": "https://glygen.org/publication/PubMed/33831707" } ] }, { "title": "Anti-Aggregative Effect of the Antioxidant DJ-1 on the TPPP/p25-Derived Pathological Associations of Alpha-Synuclein.", "journal": "Cells", "date": "2021", "authors": "Olah J, Lehotzky A, Szenasi T, Ovadi J", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" } ], "reference": [ { "type": "PubMed", "id": "34831132", "url": "https://glygen.org/publication/PubMed/34831132" } ] }, { "title": "HERV-W Envelope Triggers Abnormal Dopaminergic Neuron Process through DRD2/PP2A/AKT1/GSK3 for Schizophrenia Risk.", "journal": "Viruses", "date": "2022", "authors": "Yan Q, Wu X, Zhou P, Zhou Y, Li X, Liu Z, Tan H, Yao W, Xia Y, Zhu F", "evidence": [ { "database": "RefSeq", "id": "NP_008961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008961" } ], "reference": [ { "type": "PubMed", "id": "35062349", "url": "https://glygen.org/publication/PubMed/35062349" } ] } ], "pathway": [ { "id": "hsa:11076", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11076", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQL7-1", "protein_name": "Tubulin polymerization-promoting protein", "gene_name": "Tppp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADSKAKPTKAANKTPPKSPGDPAKAAKRLSLESEGANEGAAAAPELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK", "length": 218 }, "evidence": [ { "id": "45936651", "url": "http://www.informatics.jax.org/homology/45936651", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q7TQD2-1", "protein_name": "Tubulin polymerization-promoting protein", "gene_name": "Tppp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MADSKAKPAKAANKTPPKSPGDPARAAKRLSLESEGANEGATAAPELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK", "length": 218 }, "evidence": [ { "id": "45936651", "url": "http://www.informatics.jax.org/homology/45936651", "database": "MGI" }, { "id": "O94811", "url": "https://omabrowser.org/oma/group/O94811/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 13, "go_terms": [ { "name": "microtubule polymerization", "id": "GO:0046785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046785", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "positive regulation of protein-containing complex assembly", "id": "GO:0031334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031334", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "oligodendrocyte development", "id": "GO:0014003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014003", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "myelin assembly", "id": "GO:0032288", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032288", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "regulation of microtubule cytoskeleton organization", "id": "GO:0070507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070507", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "negative regulation of tubulin deacetylation", "id": "GO:1904428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904428", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "oligodendrocyte differentiation", "id": "GO:0048709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048709", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "microtubule bundle formation", "id": "GO:0001578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001578", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "positive regulation of myelination", "id": "GO:0031643", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031643", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "astral microtubule organization", "id": "GO:0030953", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030953", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "positive regulation of protein polymerization", "id": "GO:0032273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032273", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "microtubule nucleation by microtubule organizing center", "id": "GO:0051418", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051418", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "GTPase activity", "id": "GO:0003924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "microtubule binding", "id": "GO:0008017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "protein dimerization activity", "id": "GO:0046983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "tubulin binding", "id": "GO:0015631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "microtubule nucleator activity", "id": "GO:0140490", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140490", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "microtubule", "id": "GO:0005874", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "microtubule organizing center", "id": "GO:0005815", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" }, { "name": "postsynaptic Golgi apparatus", "id": "GO:0150051", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150051", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 12, "end_pos": 14, "annotation": "n_glycosylation_sequon" }, { "start_pos": 75, "end_pos": 77, "annotation": "n_glycosylation_sequon" }, { "start_pos": 90, "end_pos": 92, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Degraded by the proteasome; zinc-binding inhibits degradation by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "25445539", "url": "https://glygen.org/publication/PubMed/25445539" } ] }, { "annotation": "Phosphorylated by LIMK1 on serine residues; phosphorylation may alter the tubulin polymerization activity (PubMed:17693641, PubMed:18028908). Phosphorylation by LIMK2, but not LIMK1, regulates astral microtubule organization at early stage of mitosis (PubMed:22328514). Phosphorylation by ROCK1 at Ser-32, Ser-107 and Ser-159 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin, increased cell motility and entry into S-phase (PubMed:23093407, PubMed:23355470). Phosphorylation by CDK1 inhibits the microtubule polymerizing activity (PubMed:23355470).", "evidence": [ { "database": "UniProtKB", "id": "O94811", "url": "https://www.uniprot.org/uniprot/O94811" }, { "database": "PubMed", "id": "18028908", "url": "https://glygen.org/publication/PubMed/18028908" }, { "database": "PubMed", "id": "17693641", "url": "https://glygen.org/publication/PubMed/17693641" }, { "database": "PubMed", "id": "22328514", "url": "https://glygen.org/publication/PubMed/22328514" }, { "database": "PubMed", "id": "23093407", "url": "https://glygen.org/publication/PubMed/23093407" }, { "database": "PubMed", "id": "23355470", "url": "https://glygen.org/publication/PubMed/23355470" } ] } ], "interactions": [], "reactions": [ { "id": "19669", "name": "", "equation": "GTP + H2O = GDP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q08877-1", "Q6AYC2-1", "Q2TA68-1", "P61589-1", "Q6RUV5-1", "P23640-1", "O35303-1", "P21575-1", "P39052-1", "Q6AYF9-1", "Q8CFN2-1", "Q63663-1", "M0RC99-1", "Q99P74-1", "B2GUV7-1", "Q8R4Z9-1", "Q8R500-1", "D3ZQL7-1", "P97538-1", "Q6IMA3-1", "Q5BJQ5-1", "Q62636-1", "Q63486-1", "Q63487-1", "P61227-1", "P62836-1", "P63322-1", "Q04970-1", "P08644-1", "D3Z8L7-1", "P35281-1", "P36860-1", "Q6IMA7-1", "C9WPN6-1", "P20171-1", "P81795-1", "Q6AYZ1-1", "Q6AY56-1", "Q99MB4-1", "Q5XIF6-1", "P84079-1", "P68370-1", "Q68FR8-1", "Q6P9V9-1", "P51146-1", "O35509-1", "P62494-1", "Q6NYB7-1", "Q66HA6-1", "P09527-1", "P10536-1", "P05714-1", "Q8K586-1", "P62828-1", "P62332-1", "P35280-1", "P05712-1", "Q6AYB5-1", "Q6AXM7-1", "P05197-1", "P62630-1", "D3ZM99-1", "D3ZLK2-1", "Q5BJP6-1", "F1M2G3-1", "A0A8I5ZU96-1", "A0A8I6AHV4-1", "Q62639-1", "P97687-1", "P60953-2", "Q9UQ16-1", "P55039-1", "Q9Y295-1", "O00429-1", "Q05193-1", "P50570-1", "Q6NXR0-1", "Q96PP8-1", "P32455-1", "Q9H0R5-1", "Q96PP9-1", "P32456-1", "Q8N442-1", "O60841-1", "Q8IWA4-1", "O95140-1", "O60313-1", "Q8IVH4-1", "Q5S007-1", "O00194-1", "P51159-1", "P63000-1", "P20339-1", "P61586-1", "O94811-1", "P61018-1", "Q9H0U4-1", "P51148-1", "P51149-1", "Q9Y227-1", "P62820-1", "Q9NQZ7-1", "P20338-1", "P62491-1", "Q15907-1", "Q92928-1", "P61020-1", "Q9NVJ2-1", "A6NIZ1-1", "P61224-1", "A1A4Y4-1", "P61011-1", "P62834-1", "P11234-1", "Q2VIR3-1", "P41091-1", "P01112-1", "P61225-1", "Q9Y3L5-1", "Q96S79-1", "Q9NQL2-1", "Q9HB90-1", "Q9H628-1", "O14807-1", "P01116-1", "P60763-1", "P11233-1", "P01111-1", "Q99578-1", "Q96A58-1", "Q92737-1", "Q9BPW5-1", "Q7Z444-1", "P10114-1", "Q5VZM2-1", "P10301-1", "P62070-1", "Q6T310-1", "P61026-1", "Q92963-1", "Q7L523-1", "Q9NYN1-1", "P62826-1", "P62330-1", "Q8N8V2-1", "Q9NRW1-1", "Q6ZN66-1", "Q8WUD1-1", "P61006-1", "P61019-1", "Q9BSD7-1", "Q9NY65-1", "Q9H853-1", "P68366-1", "Q4V339-1", "Q8IUF1-1", "Q71U36-1", "Q9BQE3-1", "P68363-1", "Q5RIA9-1", "Q9BRT8-1", "A6NHL2-1", "Q5JTY5-1", "P84077-1", "Q6PEY2-1", "P13639-1", "P15170-1", "P0DPH7-1", "P0DPH8-1", "Q969S9-1", "Q15382-1", "P49961-1", "Q8IYD1-1", "P68104-1", "P61221-1", "Q9Y450-1", "P61021-1", "Q62293-1", "Q61107-1", "P60766-2", "Q8BZ98-1", "Q8CFB4-1", "P32233-1", "Q9QXB9-1", "Q01514-1", "Q8K1M6-1", "P39053-1", "P39054-1", "Q8C262-1", "Q5S006-1", "Q8C3X4-1", "Q9Z0E6-1", "Q9QZ85-1", "Q05D44-1", "P58281-1", "Q8C7H1-1", "Q80U63-1", "Q811U4-1", "Q99P58-1", "Q9QUI0-1", "Q9ERI2-1", "P63001-1", "Q3T9E4-1", "Q7TQD2-1", "Q9CQD1-1", "Q9CQW2-1", "P56371-1", "P62821-1", "P62492-1", "Q91ZR1-1", "P35278-1", "P46638-1", "P51150-1", "Q3TCT4-1", "Q9D1G1-1", "P61226-1", "P61027-1", "P62071-1", "Q99JI6-1", "Q8R367-1", "Q922H7-1", "Q8BU31-1", "Q80ZJ1-1", "Q80X95-1", "O08989-1", "P70426-1", "Q8K5A4-1", "P10833-1", "P70425-1", "Q61411-1", "Q5SSG5-1", "Q7TT45-1", "Q6NTA4-1", "Q99K70-1", "Q9JIW9-1", "Q08AT1-1", "P60764-1", "P62835-1", "P63321-1", "Q6IMB1-1", "P32883-1", "Q9Z0N2-1", "Q9Z0N1-1", "P08556-1", "Q7TN89-1", "A4UUI3-1", "Q8VEH6-1", "A0A0G2JDV3-1", "P68368-1", "Q91Z40-1", "Q60766-1", "A0A140LIF8-1", "Q9DCE9-1", "Q3UX10-1", "Q9JJZ2-1", "Q0GUM3-1", "E9PXC0-1", "P62331-1", "Q9CQA9-1", "P53994-1", "P59279-1", "P62827-1", "P68369-1", "P55258-1", "P61294-1", "Q61820-1", "P05214-1", "P84078-1", "Q69ZS7-1", "P05213-1", "P68373-1", "Q149F3-1", "Q8R050-1", "P14576-1", "Q921J2-1", "P55772-1", "Q8R2Q4-1", "B2RVE2-1", "P10126-1", "P61222-1", "P58252-1", "P13856-1", "P20606-1", "P01119-1", "P01120-1", "P05453-1", "P06780-1", "P06781-1", "P09733-1", "P09734-1", "P11076-1", "P19073-1", "P32324-1", "P32481-1", "P32769-1", "P53893-1", "P54861-1", "Q00246-1", "P39730-1", "P46943-1", "P38297-1", "P53729-1", "P20424-1", "P53290-1", "Q00582-1", "Q54Y30-1", "Q54XP6-1", "Q54XD8-1", "Q55CA9-1", "Q55CB0-1", "Q55CB7-1", "Q55CB8-1", "Q55CB9-1", "Q55CC0-1", "Q75K18-1", "Q869Q0-1", "Q86L51-1", "B0G189-1", "O00909-1", "P03967-1", "P0CT31-1", "P15064-1", "P15112-1", "P18613-1", "P32252-1", "P32253-1", "P32254-1", "P32255-1", "P36409-1", "P36411-1", "Q54MH8-1", "Q55AX0-1", "Q55BW0-1", "Q55F94-1", "P08645-1", "P08646-1", "P40793-1", "Q24208-1", "P04388-1", "P27619-1", "Q7YU24-1", "P48555-1", "Q9VRH6-1", "A1Z9N0-1", "O18412-1", "P06604-1", "P06606-1", "P61209-1", "P06603-1", "P06605-1", "Q9W074-1", "O18333-1", "Q9V3I2-1", "Q9VRY2-1", "O76742-1", "P13060-1", "Q9VM20-1" ], "evidence": [ { "id": "19669", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19669" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JDV3", "gene_name": "Gbp6", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0A0G2JDV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JDV3" } ] } ] }, { "uniprot_ac": "A0A140LIF8", "gene_name": "Irgm2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A0A140LIF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A140LIF8" } ] } ] }, { "uniprot_ac": "A0A8I5ZU96", "gene_name": "ENSRNOG00000063798", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZU96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZU96" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A8I5ZU96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZU96" } ] } ] }, { "uniprot_ac": "A0A8I6AHV4", "gene_name": "LOC367858", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AHV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AHV4" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A0A8I6AHV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AHV4" } ] } ] }, { "uniprot_ac": "A1A4Y4", "gene_name": "IRGM", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A1A4Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1A4Y4" } ] } ] }, { "uniprot_ac": "A1Z9N0", "gene_name": "Opa1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "A1Z9N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9N0" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "A1Z9N0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9N0" } ] } ] }, { "uniprot_ac": "A4UUI3", "gene_name": "Gbp4", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A4UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4UUI3" } ] } ] }, { "uniprot_ac": "A6NHL2", "gene_name": "TUBAL3", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "A6NHL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NHL2" } ] } ] }, { "uniprot_ac": "A6NIZ1", "gene_name": "RAP1BL", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "A6NIZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NIZ1" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "A6NIZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NIZ1" } ] } ] }, { "uniprot_ac": "B0G189", "gene_name": "guf1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "B0G189", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G189" } ] } ] }, { "uniprot_ac": "B2GUV7", "gene_name": "Eif5b", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "B2GUV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUV7" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "B2GUV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUV7" } ] } ] }, { "uniprot_ac": "B2RVE2", "gene_name": "Rergl", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "B2RVE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RVE2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "B2RVE2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RVE2" } ] } ] }, { "uniprot_ac": "C9WPN6", "gene_name": "Eif2s3y", "activity": [ { "ec_number": "3.6.5.3", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "C9WPN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9WPN6" } ] }, { "ec_number": "3.6.5.3", "activity": "", "evidence": [ { "id": "C9WPN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9WPN6" } ] } ] }, { "uniprot_ac": "D3Z8L7", "gene_name": "Rras", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "D3Z8L7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8L7" } ] } ] }, { "uniprot_ac": "D3ZLK2", "gene_name": "Rasl12", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "D3ZLK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLK2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "D3ZLK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLK2" } ] } ] }, { "uniprot_ac": "D3ZM99", "gene_name": "Rergl", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "D3ZM99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZM99" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "D3ZM99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZM99" } ] } ] }, { "uniprot_ac": "D3ZQL7", "gene_name": "Tppp", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "D3ZQL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQL7" } ] } ] }, { "uniprot_ac": "E9PXC0", "gene_name": "Srp54c", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "E9PXC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PXC0" } ] } ] }, { "uniprot_ac": "F1M2G3", "gene_name": "Rerg", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "F1M2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M2G3" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "F1M2G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M2G3" } ] } ] }, { "uniprot_ac": "M0RC99", "gene_name": "Rab5a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "M0RC99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RC99" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "M0RC99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RC99" } ] } ] }, { "uniprot_ac": "O00194", "gene_name": "RAB27B", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O00194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00194" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "O00194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00194" } ] } ] }, { "uniprot_ac": "O00429", "gene_name": "DNM1L", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O00429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00429" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "O00429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00429" } ] } ] }, { "uniprot_ac": "O00909", "gene_name": "arfA", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "O00909", "database": 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