{
    "uniprot_canonical_ac": "O77203-1",
    "uniprot_ac": "O77203",
    "uniprot_id": "PIAA_DICDI",
    "mass": {
        "chemical_mass": 129529.0,
        "monoisotopic_mass": 129529.0
    },
    "refseq": {
        "ac": "XP_642614",
        "name": "cytosolic regulator of adenylate cyclase",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642614"
    },
    "gene_names": [
        {
            "name": "piaA",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "id": "O77203"
        },
        {
            "name": "DDB_G0277399",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "id": "O77203"
        },
        {
            "name": "DG1117",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "id": "O77203"
        },
        {
            "name": "amiA",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "id": "O77203"
        },
        {
            "name": "piaA",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642614",
            "id": "XP_642614"
        },
        {
            "name": "pia",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "id": "O77203"
        }
    ],
    "protein_names": [
        {
            "name": "Protein pianissimo A",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "O77203"
        },
        {
            "name": "Developmental gene 1117 protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O77203"
        },
        {
            "name": "Protein pianissimo",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O77203"
        },
        {
            "name": "TORC2 subunit piaA",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O77203"
        },
        {
            "name": "Target of rapamycin complex 2 subunit piaA",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "O77203"
        },
        {
            "name": "cytosolic regulator of adenylate cyclase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642614",
            "id": "XP_642614"
        },
        {
            "name": "cytosolic regulator of adenylyl cyclase",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642614",
            "id": "XP_642614"
        }
    ],
    "function": [
        {
            "annotation": "Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function redundantly. Both proteins are integral components of the adenylyl cyclase activation pathway.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203#function"
                },
                {
                    "database": "PubMed",
                    "id": "11973364",
                    "url": "https://glygen.org/publication/PubMed/11973364"
                },
                {
                    "database": "PubMed",
                    "id": "9389653",
                    "url": "https://glygen.org/publication/PubMed/9389653"
                },
                {
                    "database": "PubMed",
                    "id": "18635356",
                    "url": "https://glygen.org/publication/PubMed/18635356"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 917,
            "end_pos": 917,
            "sequence_org": "G",
            "sequence_mut": "D",
            "comment": "Temperature-sensitive phenotype and defective G protein-linked adenylyl cyclase activation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                },
                {
                    "database": "PubMed",
                    "id": "12413895",
                    "url": "https://glygen.org/publication/PubMed/12413895"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Dictyostelium discoideum",
            "taxid": 44689,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "common_name": "Cellular slime molds"
        }
    ],
    "gene": [
        {
            "name": "piaA",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "locus": {}
        }
    ],
    "crossref": [
        {
            "id": "DDB_G0277399",
            "url": "http://dictybase.org/gene/DDB_G0277399",
            "database": "dictyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "8621031",
            "url": "https://www.ncbi.nlm.nih.gov/gene/8621031",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR016024",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028267",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028267",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028268",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028268",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029451",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029451",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029452",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029452",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029453",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029453",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "ddi:DDB_G0277399",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0277399",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MPWNMEV",
            "url": "https://omabrowser.org/oma/group/MPWNMEV/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13298",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13298",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13298:SF11",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13298:SF11",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF14663",
            "url": "http://pfam.xfam.org/family/PF14663",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF14664",
            "url": "http://pfam.xfam.org/family/PF14664",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF14666",
            "url": "http://pfam.xfam.org/family/PF14666",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF14668",
            "url": "http://pfam.xfam.org/family/PF14668",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_O77203",
            "url": "http://purl.obolibrary.org/obo/PR_O77203",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-DDI-1257604",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1257604",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-389357",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-389357",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-5218920",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5218920",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-DDI-6804757",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6804757",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "XP_642614",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642614",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O77203",
            "url": "https://www.uniprot.org/uniprot/O77203",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "O77203-1",
            "url": "https://www.uniprot.org/uniprot/O77203-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MTSSDSSVNTTSSSFGNISISSPNHSSSTPPLNNGNGNNVSASETELKKHVLYSLQCLDEKTLTLKVKLDHLNKLVELKKSIPDLNKLGISPTQLYKSVRPFIALPPKTIRTAGLRVMRYYLSNSNNVKELLDLKVQYFITRSLERDKHSEPERIQALKIIRTIMEIDCSLMPHCFVKGLVSIAENQEDNFCRVCLECLTEISIRNPQISSHCGGIRTVFDAVLDPFYQGIQESLLICILYLLSDKDTRIYIRPKSDLEIILAPLTNSFNIGVKLKGASKEKEKEKEKEDEVAMKKWTASSKAVLTLIKSWIGIISLNSDDQGLKSVVDTLRMPQIELQEKALDSIFEIFRVQLPKSIQETFGPQKATQTFNFGSETLQDLPSRTRSLRHNLLNNYLSVLLIAFIDNGLIEGLVYLGNYVANRDGMSEQEKECSKNISLKSTVLLAELLHMSNALLPPSQCAKLQTLPSLVNSAISFRLDPRLRSSSNTMVTNLHSYSHNKSSTTLMDSTLAIGLTGANKWRRIKGQDRRLDKVDDVKMKMEWHMDDNQFQQKIKDTQVLVTKDYQKWSWELMFELLEGPLNNPQHLSNTLKTKFIKRILSFLRPNKKLFSTMAWTTENLKYVRTACVALEVLISHEIGFDFLKDNKTIIQIADMLKVELDYNIKPPPSSSSSSENKKDNVRLLNPEKVLKTMSREYFTMLGTLSSNLLGLEILARNNIFDYIKPLAELPGRDDLSHLIMTSLDYNVNGASRTILQKILTSSSRVVRYLATKYLRFLLRSGVQDFSNWGVELLVQQLNDVDAKVSALSLNVLDEACDDPSCLEVLIDLKPNLLKLGKPGKSLLLRFLSSPKGLENLLQNNGFVEQEEQLWITSENATYVNAIESAVSESLSPSVWRFKEAPDGSSTSGVYLPPHFFGELAKTEKGCQLIRKSNNYQRFLKIIQDPTAKQLDKRASLIAIGHIGSSVDGYSFVKESDTIKLLIGIAEKSQCLALRSTCFYALGMISCIEEAQPIFNSFGWESPSDLNSRILLPKDLKNSTFLSVPQYQYQGSWADHSFETLPSNHFSDPIKNEIISFVGNLSSHITAEGASKNLKRLKIKYPDHFATSEILNAVFILLNTFKYRLGARRFIYDLFDVAIFSSDPYHDLN",
        "length": 1148,
        "header": "sp|O77203-1|PIAA_DICDI Isoform 1 of Protein pianissimo A  OS=Dictyostelium discoideum OX=44689 GN=piaA PE=1 SV=1 CANONICAL=O77203-1"
    },
    "isoforms": [
        {
            "isoform_ac": "O77203-1",
            "url": "",
            "sequence": {
                "sequence": "MTSSDSSVNTTSSSFGNISISSPNHSSSTPPLNNGNGNNVSASETELKKHVLYSLQCLDEKTLTLKVKLDHLNKLVELKKSIPDLNKLGISPTQLYKSVRPFIALPPKTIRTAGLRVMRYYLSNSNNVKELLDLKVQYFITRSLERDKHSEPERIQALKIIRTIMEIDCSLMPHCFVKGLVSIAENQEDNFCRVCLECLTEISIRNPQISSHCGGIRTVFDAVLDPFYQGIQESLLICILYLLSDKDTRIYIRPKSDLEIILAPLTNSFNIGVKLKGASKEKEKEKEKEDEVAMKKWTASSKAVLTLIKSWIGIISLNSDDQGLKSVVDTLRMPQIELQEKALDSIFEIFRVQLPKSIQETFGPQKATQTFNFGSETLQDLPSRTRSLRHNLLNNYLSVLLIAFIDNGLIEGLVYLGNYVANRDGMSEQEKECSKNISLKSTVLLAELLHMSNALLPPSQCAKLQTLPSLVNSAISFRLDPRLRSSSNTMVTNLHSYSHNKSSTTLMDSTLAIGLTGANKWRRIKGQDRRLDKVDDVKMKMEWHMDDNQFQQKIKDTQVLVTKDYQKWSWELMFELLEGPLNNPQHLSNTLKTKFIKRILSFLRPNKKLFSTMAWTTENLKYVRTACVALEVLISHEIGFDFLKDNKTIIQIADMLKVELDYNIKPPPSSSSSSENKKDNVRLLNPEKVLKTMSREYFTMLGTLSSNLLGLEILARNNIFDYIKPLAELPGRDDLSHLIMTSLDYNVNGASRTILQKILTSSSRVVRYLATKYLRFLLRSGVQDFSNWGVELLVQQLNDVDAKVSALSLNVLDEACDDPSCLEVLIDLKPNLLKLGKPGKSLLLRFLSSPKGLENLLQNNGFVEQEEQLWITSENATYVNAIESAVSESLSPSVWRFKEAPDGSSTSGVYLPPHFFGELAKTEKGCQLIRKSNNYQRFLKIIQDPTAKQLDKRASLIAIGHIGSSVDGYSFVKESDTIKLLIGIAEKSQCLALRSTCFYALGMISCIEEAQPIFNSFGWESPSDLNSRILLPKDLKNSTFLSVPQYQYQGSWADHSFETLPSNHFSDPIKNEIISFVGNLSSHITAEGASKNLKRLKIKYPDHFATSEILNAVFILLNTFKYRLGARRFIYDLFDVAIFSSDPYHDLN",
                "length": 1148,
                "header": "sp|O77203-1|PIAA_DICDI Isoform 1 of Protein pianissimo A  OS=Dictyostelium discoideum OX=44689 GN=piaA PE=1 SV=1 CANONICAL=O77203-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Genetic and morphological evidence for two parallel pathways of cell-cycle-coupled cytokinesis in Dictyostelium.",
            "journal": "Journal of cell science",
            "date": "2002-05-15",
            "authors": "Nagasaki Akira, de Hostos Eugenio L, Uyeda Taro Q P",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11973364",
                    "url": "https://glygen.org/publication/PubMed/11973364"
                }
            ]
        },
        {
            "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.",
            "journal": "Nature",
            "date": "2002",
            "authors": "Gl\u00f6ckner Gernot, Eichinger Ludwig, Szafranski Karol, Pachebat Justin A, Bankier Alan T, Dear Paul H, Lehmann R\u00fcdiger, Baumgart Cornelia, Parra Gen\u00eds, Abril Josep F, Guig\u00f3 Roderic, Kumpf Kai, Tunggal Budi, Cox Edward, Quail Michael A, Platzer Matthias, Rosenthal Andr\u00e9, Noegel Angelika A,",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12097910",
                    "url": "https://glygen.org/publication/PubMed/12097910"
                }
            ]
        },
        {
            "title": "Temperature-sensitive inhibition of development in Dictyostelium due to a point mutation in the piaA gene.",
            "journal": "Developmental biology",
            "date": "2002-11-01",
            "authors": "Pergolizzi Barbara, Peracino Barbara, Silverman James, Ceccarelli Adriano, Noegel Angelika, Devreotes Peter, Bozzaro Salvatore",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12413895",
                    "url": "https://glygen.org/publication/PubMed/12413895"
                }
            ]
        },
        {
            "title": "The genome of the social amoeba Dictyostelium discoideum.",
            "journal": "Nature",
            "date": "2005",
            "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15875012",
                    "url": "https://glygen.org/publication/PubMed/15875012"
                }
            ]
        },
        {
            "title": "TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.",
            "journal": "Mol. Biol. Cell",
            "date": "2005",
            "authors": "Lee Susan, Comer Frank I, Sasaki Atsuo, McLeod Ian X, Duong Yung, Okumura Koichi, Yates John R, Parent Carole A, Firtel Richard A",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16079174",
                    "url": "https://glygen.org/publication/PubMed/16079174"
                }
            ]
        },
        {
            "title": "Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes.",
            "journal": "Bioinformatics",
            "date": "2005",
            "authors": "Booth Ezgi O, Van Driessche Nancy, Zhuchenko Olga, Kuspa Adam, Shaulsky Gad",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16234315",
                    "url": "https://glygen.org/publication/PubMed/16234315"
                }
            ]
        },
        {
            "title": "High-throughput analysis of spatio-temporal dynamics in Dictyostelium.",
            "journal": "Genome Biol.",
            "date": "2007",
            "authors": "Sawai Satoshi, Guan Xiao-Juan, Kuspa Adam, Cox Edward C",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17659086",
                    "url": "https://glygen.org/publication/PubMed/17659086"
                }
            ]
        },
        {
            "title": "PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.",
            "journal": "Current biology : CB",
            "date": "2008-07-22",
            "authors": "Kamimura Yoichiro, Xiong Yuan, Iglesias Pablo A, Hoeller Oliver, Bolourani Parvin, Devreotes Peter N",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "18635356",
                    "url": "https://glygen.org/publication/PubMed/18635356"
                }
            ]
        },
        {
            "title": "A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium.",
            "journal": "Genes & development",
            "date": "1997-12-01",
            "authors": "Chen M Y, Long Y, Devreotes P N",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9389653",
                    "url": "https://glygen.org/publication/PubMed/9389653"
                }
            ]
        },
        {
            "title": "A novel Dictyostelium discoideum gene required for cAMP-dependent cell aggregation.",
            "journal": "Biochem. Biophys. Res. Commun.",
            "date": "1998",
            "authors": "Nagasaki A, Sutoh K, Adachi H, Sutoh K",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "O77203",
                    "url": "https://www.uniprot.org/uniprot/O77203"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "9514897",
                    "url": "https://glygen.org/publication/PubMed/9514897"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "ddi:DDB_G0277399",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0277399",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-DDI-1257604",
            "name": "PIP3 activates AKT signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1257604",
            "resource": "Reactome",
            "description": "PIP3 activates AKT signaling"
        },
        {
            "id": "R-DDI-389357",
            "name": "CD28 dependent PI3K/Akt signaling",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-389357",
            "resource": "Reactome",
            "description": "CD28 dependent PI3K/Akt signaling"
        },
        {
            "id": "R-DDI-5218920",
            "name": "VEGFR2 mediated vascular permeability",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-5218920",
            "resource": "Reactome",
            "description": "VEGFR2 mediated vascular permeability"
        },
        {
            "id": "R-DDI-6804757",
            "name": "Regulation of TP53 Degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-6804757",
            "resource": "Reactome",
            "description": "Regulation of TP53 Degradation"
        }
    ],
    "orthologs": [],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 16,
                "go_terms": [
                    {
                        "name": "regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction",
                        "id": "GO:0051896",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051896",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of Ras protein signal transduction",
                        "id": "GO:0046580",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046580",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chemotaxis",
                        "id": "GO:0006935",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction",
                        "id": "GO:0051897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitotic cytokinesis",
                        "id": "GO:0000281",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "response to electrical stimulus",
                        "id": "GO:0051602",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051602",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of phagocytosis",
                        "id": "GO:0050765",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050765",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "establishment of cell polarity",
                        "id": "GO:0030010",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030010",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "TORC2 signaling",
                        "id": "GO:0038203",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038203",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway",
                        "id": "GO:0106070",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106070",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of myosin II filament assembly",
                        "id": "GO:0043520",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043520",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "sorocarp development",
                        "id": "GO:0030587",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030587",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "aggregation involved in sorocarp development",
                        "id": "GO:0031152",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031152",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chemotaxis to cAMP",
                        "id": "GO:0043327",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043327",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "G protein-coupled chemorepellent receptor signaling pathway",
                        "id": "GO:0140986",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140986",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of asexual reproduction",
                        "id": "GO:1903665",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903665",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "TORC2 complex",
                        "id": "GO:0031932",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031932",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "guanyl-nucleotide exchange factor activity",
                        "id": "GO:0005085",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "adenylate cyclase activator activity",
                        "id": "GO:0010856",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010856",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "O77203",
                                "url": "https://www.uniprot.org/uniprot/O77203"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 1037,
            "end_pos": 1039,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 1079,
            "end_pos": 1081,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 17,
            "end_pos": 19,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 24,
            "end_pos": 26,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 39,
            "end_pos": 41,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 436,
            "end_pos": 438,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 500,
            "end_pos": 502,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 646,
            "end_pos": 648,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 875,
            "end_pos": 877,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 9,
            "end_pos": 11,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [],
    "sequence_features": {
        "n_linked_sites": [],
        "o_linked_sites": [],
        "snv_sites": [],
        "glycation_sites": [],
        "phosphorylation_sites": [],
        "sequon_annotation_sites": [
            {
                "start_pos": 1037,
                "end_pos": 1039
            },
            {
                "start_pos": 1079,
                "end_pos": 1081
            },
            {
                "start_pos": 17,
                "end_pos": 19
            },
            {
                "start_pos": 24,
                "end_pos": 26
            },
            {
                "start_pos": 39,
                "end_pos": 41
            },
            {
                "start_pos": 436,
                "end_pos": 438
            },
            {
                "start_pos": 500,
                "end_pos": 502
            },
            {
                "start_pos": 646,
                "end_pos": 648
            },
            {
                "start_pos": 875,
                "end_pos": 877
            },
            {
                "start_pos": 9,
                "end_pos": 11
            }
        ]
    },
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 10
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}