{ "uniprot_canonical_ac": "O76094-1", "uniprot_ac": "O76094", "uniprot_id": "SRP72_HUMAN", "mass": { "chemical_mass": 74606.0, "monoisotopic_mass": 74606.0 }, "refseq": { "ac": "NP_001254651", "name": "signal recognition particle subunit SRP72 isoform 2", "summary": "This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" }, "gene_names": [ { "name": "SRP72", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O76094", "id": "O76094" }, { "name": "BMFF; BMFS1; HEL103", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651", "id": "NP_001254651" }, { "name": "SRP72", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651", "id": "NP_001254651" } ], "protein_names": [ { "name": "Signal recognition particle subunit SRP72", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O76094" }, { "name": "SRP72", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O76094" }, { "name": "Signal recognition particle 72 kDa protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O76094" }, { "name": "signal recognition particle 72 kDa protein; signal recognition particle subunit SRP72; epididymis luminal protein 103; signal recognition particle 72kD; signal recognition particle 72kDa", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651", "id": "NP_001254651" }, { "name": "signal recognition particle subunit SRP72 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651", "id": "NP_001254651" } ], "function": [ { "annotation": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68 (PubMed:27899666, PubMed:21073748). Can bind 7SL RNA with low affinity (PubMed:27899666, PubMed:21073748). The SRP complex possibly participates in the elongation arrest function (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094#function" }, { "database": "PubMed", "id": "27899666", "url": "https://glygen.org/publication/PubMed/27899666" }, { "database": "PubMed", "id": "34020957", "url": "https://glygen.org/publication/PubMed/34020957" }, { "database": "UniProtKB", "id": "P38688", "url": "https://www.uniprot.org/uniprot/P38688#function" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "annotation": "E show that SRP RNA does not bind to the ribosome, while SRP binds with nanomolar affinity involving a two-step mechanism of the key-player SRP54. Ultrasensitive binding of SRP68/72 indicates avidity by multiple binding sites that are dominated by the C-terminus of SRP72", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" }, { "database": "PubMed", "id": "30649417", "url": "https://glygen.org/publication/PubMed/30649417" } ] }, { "annotation": "SRP72 depletion is associated with elevated levels of apoptosis after irradiation.", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" }, { "database": "PubMed", "id": "28494188", "url": "https://glygen.org/publication/PubMed/28494188" } ] }, { "annotation": "The crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP have been presented.", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" }, { "database": "PubMed", "id": "27899666", "url": "https://glygen.org/publication/PubMed/27899666" } ] }, { "annotation": "The essential role of the SRP68-SRP72 interaction in the signal recognition particle-mediated protein translocation", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "annotation": "This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" } ] } ], "disease": [ { "disease_id": "MONDO:0013851", "recommended_name": { "id": "MONDO:0013851", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013851", "name": "autosomal dominant aplasia and myelodysplasia", "description": "" }, "synonyms": [ { "id": "MONDO:0013851", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013851", "name": "autosomal dominant aplastic anaemia and myelodysplasia", "description": "" }, { "id": "MONDO:0013851", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013851", "name": "autosomal dominant aplastic anemia and myelodysplasia", "description": "" }, { "id": "MONDO:0013851", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013851", "name": "bone marrow failure syndrome type 1", "description": "" }, { "id": "MONDO:0013851", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013851", "name": "BMFS1", "description": "" }, { "id": "MONDO:0013851", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013851", "name": "bone marrow failure syndrome 1", "description": "" }, { "id": "MIM:614675", "resource": "MIM", "url": "https://www.omim.org/entry/614675", "name": "Bone marrow failure syndrome 1", "description": "Bone marrow failure syndrome 1" } ], "evidence": [ { "id": "614675", "database": "MIM", "url": "https://www.omim.org/entry/614675" } ] } ], "snv": [ { "evidence": [ { "id": "rs989384434", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs989384434" }, { "id": "rs989384434", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs989384434#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 511, "end_pos": 511, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SMS->NMS).", "chr_id": "4", "chr_pos": "56491460", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S511", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1450810326", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1450810326" }, { "id": "rs1450810326", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1450810326#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 639, "end_pos": 639, "sequence_org": "S", "sequence_mut": "G", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->G).", "chr_id": "4", "chr_pos": "56501760", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S639", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs753233079", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753233079" }, { "id": "rs753233079", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753233079" }, { "id": "rs753233079", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs753233079" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 68, "end_pos": 68, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NVI->NVT).", "chr_id": "4", "chr_pos": "56471791", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I68", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 113, "end_pos": 131, "sequence_org": "ELYGQVLYRLERYDECLAV", "sequence_mut": "", "comment": "Loss of interaction with SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 11, "end_pos": 44, "sequence_org": "VPALWSEVNRYGQNGDFTRALKTVNKILQINKDD", "sequence_mut": "", "comment": "Loss of interaction with SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 132, "end_pos": 165, "sequence_org": "YRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVV", "sequence_mut": "", "comment": "Loss of interaction with SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 136, "end_pos": 137, "sequence_org": "VR", "sequence_mut": "AA", "comment": "Stronger interaction with SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 44, "end_pos": 44, "sequence_org": "D", "sequence_mut": "E", "comment": "Reduced interaction with SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 45, "end_pos": 45, "sequence_org": "V", "sequence_mut": "I", "comment": "Reduced interaction with SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 53, "end_pos": 53, "sequence_org": "V", "sequence_mut": "I", "comment": "Reduced interaction with SRP68. Diminished localization to endoplasmic reticulum.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "start_pos": 553, "end_pos": 558, "sequence_org": "KKKKKK", "sequence_mut": "AAAAAA", "comment": "Loss of RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 555, "end_pos": 556, "sequence_org": "KK", "sequence_mut": "AA", "comment": "Diminished RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 56, "end_pos": 56, "sequence_org": "I", "sequence_mut": "A", "comment": "Loss of interaction with SRP72; when associated with A-598 in SRP68.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "27899666", "url": "https://glygen.org/publication/PubMed/27899666" } ] }, { "start_pos": 577, "end_pos": 578, "sequence_org": "WL", "sequence_mut": "AA", "comment": "Loss of RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 579, "end_pos": 579, "sequence_org": "P", "sequence_mut": "A", "comment": "Strongly reduced RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 579, "end_pos": 580, "sequence_org": "PM", "sequence_mut": "AA", "comment": "Diminished RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 580, "end_pos": 580, "sequence_org": "M", "sequence_mut": "A", "comment": "Does not affect RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 581, "end_pos": 582, "sequence_org": "RE", "sequence_mut": "AA", "comment": "Diminished RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 583, "end_pos": 584, "sequence_org": "RS", "sequence_mut": "AA", "comment": "Loss of RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 585, "end_pos": 586, "sequence_org": "YY", "sequence_mut": "AA", "comment": "Diminished RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 587, "end_pos": 588, "sequence_org": "RG", "sequence_mut": "AA", "comment": "No impact on RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 589, "end_pos": 590, "sequence_org": "RK", "sequence_mut": "AA", "comment": "No impact on RNA binding.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "start_pos": 86, "end_pos": 86, "sequence_org": "Y", "sequence_mut": "C", "comment": "Loss of interaction with SRP68. Diminished localization to endoplasmic reticulum.", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "91.97", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "95.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "93.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "92.07", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "95.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "95.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "89.86", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "95.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "93.19", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "91.56", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "94.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O76094", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76094" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", 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"MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", 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}, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", 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in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O76094", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76094" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" } ], "common_name": "Human" } ], "gene": [ { "name": "SRP72", "url": "https://www.uniprot.org/uniprot/O76094", "locus": { "chromosome": "4", "start_pos": 41086, "end_pos": 5022, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "LRG_1151", "url": "https://www.ensembl.org/id/LRG_1151" } ] } } ], "crossref": [ { "id": "ENSG00000174780", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000174780", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "SRP72", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SRP72", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "6731", "url": "https://www.ncbi.nlm.nih.gov/gene/6731", "database": "GeneID", "categories": [ "Genome Annotation" 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"Protein Classification" ] }, { "id": "hsa:6731", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6731", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "602122", "url": "http://www.omim.org/entry/602122", "database": "MIM", "categories": [ "Other" ] }, { "id": "614675", "url": "http://www.omim.org/entry/614675", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O76094", "url": "https://www.nextprot.org/entry/NX_O76094", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O76094", "url": "https://oglcnac.org/atlas/detail/O76094", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "NDMKVLA", "url": "https://omabrowser.org/oma/group/NDMKVLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "91080at2759", "url": "http://www.orthodb.org/?query=91080at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14094", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14094", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14094:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14094:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "5M72", "url": "https://www.rcsb.org/structure/5M72", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5M73", "url": "https://www.rcsb.org/structure/5M73", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5WRV", "url": "https://www.rcsb.org/structure/5WRV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5WRW", "url": "https://www.rcsb.org/structure/5WRW", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7NFX", "url": "https://www.rcsb.org/structure/7NFX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF08492", "url": "http://pfam.xfam.org/family/PF08492", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "http://pfam.xfam.org/family/PF13181", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17004", "url": "http://pfam.xfam.org/family/PF17004", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O76094", "url": "https://pharos.nih.gov/targets/O76094", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O76094", "url": "http://purl.obolibrary.org/obo/PR_O76094", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1799339", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D6RDY6", "url": "https://www.uniprot.org/uniprot/D6RDY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RDY6-1", "url": "https://www.uniprot.org/uniprot/D6RDY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76094-1", "url": "https://www.uniprot.org/uniprot/O76094-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76094-2", "url": "https://www.uniprot.org/uniprot/O76094-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "R4GNC1", "url": "https://www.uniprot.org/uniprot/R4GNC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "R4GNC1-1", "url": "https://www.uniprot.org/uniprot/R4GNC1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 671, "header": "sp|O76094-1|SRP72_HUMAN Isoform 1 of Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3 CANONICAL=O76094-1" }, "isoforms": [ { "isoform_ac": "D6RDY6-1", "url": "", "sequence": { "sequence": "XNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSAL", "length": 335, "header": "tr|D6RDY6-1|SRP72_HUMAN Computationally mapped isoform of Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3 CANONICAL=O76094-1" }, "locus": { "chromosome": "4", "start_pos": 56489400, "end_pos": 56467736, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000505314.2", "url": "https://www.ensembl.org/id/ENST00000505314.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000425190.3", "url": "https://www.ensembl.org/id/ENSP00000425190.3" } ] } }, { "isoform_ac": "O76094-1", "url": "", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 671, "header": "sp|O76094-1|SRP72_HUMAN Isoform 1 of Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3 CANONICAL=O76094-1" }, "locus": { "chromosome": "4", "start_pos": 56501858, "end_pos": 56467636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000642900.1", "url": "https://www.ensembl.org/id/ENST00000642900.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000495128.1", "url": "https://www.ensembl.org/id/ENSP00000495128.1" } ] } }, { "isoform_ac": "O76094-2", "url": "", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQAEQCRKISASLQSQSPEHLLPVLIQAAQLCREKQHTKAIELLQEFSDQHPENAAEIKLTMAQLKISQGNISKACLILRSIEELKHKPGMVSALVTMYSHEEDIDSAIEVFTQAIQWYQNHQPKSPAHLSLIREAANFKLKYGRKKEAISDLQQLWKQNPKDIHTLAQLISAYSLVDPEKAKALSKHLPSSDSMSLKVDVEALENSAGATYIRKKGGKVTGDSQPKEQGQGDLKKKKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQGATAGASSELDASKTVSSPPTSPRPGSAATVSASTSNIIPPRHQKPAGAPATKKKQQQKKKKGGKGGW", "length": 610, "header": "sp|O76094-2|SRP72_HUMAN Isoform 2 of Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3 CANONICAL=O76094-1" }, "locus": { "chromosome": "4", "start_pos": 56501858, "end_pos": 56467636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000510663.6", "url": "https://www.ensembl.org/id/ENST00000510663.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000424576.1", "url": "https://www.ensembl.org/id/ENSP00000424576.1" } ] } }, { "isoform_ac": "R4GNC1-1", "url": "", "sequence": { "sequence": "MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEGWKFVKLICKYNVHITL", "length": 220, "header": "tr|R4GNC1-1|SRP72_HUMAN Computationally mapped isoform of Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=1 CANONICAL=O76094-1" }, "locus": { "chromosome": "4", "start_pos": 56474441, "end_pos": 56467636, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000504757.2", "url": "https://www.ensembl.org/id/ENST00000504757.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000473576.1", "url": "https://www.ensembl.org/id/ENSP00000473576.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 639, "start_aa": "Ser", "end_pos": 639, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser639", "evidence": [ { "id": "O76094", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O76094" }, { "id": "31373491", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 655, "start_aa": "Thr", 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Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "O76094-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O76094-1" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O76094-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O76094-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Eukaryotic protein synthesis: still a mystery.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Merrick WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1799339" } ], "reference": [ { "type": "PubMed", "id": "20444697", "url": "https://glygen.org/publication/PubMed/20444697" } ] }, { "title": "Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA.", "journal": "BMC molecular biology", "date": "2010", "authors": "Iakhiaeva E, Iakhiaev A, Zwieb C", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" } ], "reference": [ { "type": "PubMed", "id": "21073748", "url": "https://glygen.org/publication/PubMed/21073748" } ] }, { "title": "Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-alpha-acetylation features.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" } ], "reference": [ { "type": "PubMed", "id": "22223895", "url": "https://glygen.org/publication/PubMed/22223895" } ] }, { "title": "Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.", "journal": "American journal of human genetics", "date": "2012", "authors": "Kirwan M, Walne AJ, Plagnol V, Velangi M, Ho A, Hossain U, Vulliamy T, Dokal I", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" } ], "reference": [ { "type": "PubMed", "id": "22541560", "url": "https://glygen.org/publication/PubMed/22541560" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "iPTMnet", "id": "O76094", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O76094" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "iPTMnet", "id": "O76094", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O76094" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2014", "authors": "Impens F, Radoshevich L, Cossart P, Ribet D", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" } ], "reference": [ { "type": "PubMed", "id": "25114211", "url": "https://glygen.org/publication/PubMed/25114211" } ] }, { "title": "The human embryonic stem cell proteome revealed by multidimensional fractionation followed by tandem mass spectrometry.", "journal": "Proteomics", "date": "2015", "authors": "Zhao P, Schulz TC, Sherrer ES, Weatherly DB, Robins AJ, Wells L", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" }, { "database": "O-GlcNAc Atlas", "id": "O76094", "url": "https://oglcnac.org/atlas/detail/O76094" } ], "reference": [ { "type": "PubMed", "id": "25367160", "url": "https://glygen.org/publication/PubMed/25367160" } ] }, { "title": "Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.", "journal": "Nucleic acids research", "date": "2017", "authors": "Becker MM, Lapouge K, Segnitz B, Wild K, Sinning I", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" } ], "reference": [ { "type": "PubMed", "id": "27899666", "url": "https://glygen.org/publication/PubMed/27899666" } ] }, { "title": "Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.", "journal": "Journal of molecular cell biology", "date": "2017", "authors": "Gao Y, Zhang Q, Lang Y, Liu Y, Dong X, Chen Z, Tian W, Tang J, Wu W, Tong Y, Chen Z", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" }, { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" } ], "reference": [ { "type": "PubMed", "id": "28369529", "url": "https://glygen.org/publication/PubMed/28369529" } ] }, { "title": "Depletion of signal recognition particle 72kDa increases radiosensitivity.", "journal": "Cancer biology & therapy", "date": "2017", "authors": "Prevo R, Tiwana GS, Maughan TS, Buffa FM, McKenna WG, Higgins GS", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" } ], "reference": [ { "type": "PubMed", "id": "28494188", "url": "https://glygen.org/publication/PubMed/28494188" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.", "journal": "Nucleic acids research", "date": "2019", "authors": "Wild K, Juaire KD, Soni K, Shanmuganathan V, Hendricks A, Segnitz B, Beckmann R, Sinning I", "evidence": [ { "database": "RefSeq", "id": "NP_001254651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254651" } ], "reference": [ { "type": "PubMed", "id": "30649417", "url": "https://glygen.org/publication/PubMed/30649417" } ] }, { "title": "Aspartate Residues Far from the Active Site Drive O-GlcNAc Transferase Substrate Selection.", "journal": "Journal of the American Chemical Society", "date": "2019", "authors": "Joiner CM, Levine ZG, Aonbangkhen C, Woo CM, Walker S", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O76094", "url": "https://oglcnac.org/atlas/detail/O76094" } ], "reference": [ { "type": "PubMed", "id": "31373491", "url": "https://glygen.org/publication/PubMed/31373491" } ] }, { "title": "Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.", "journal": "ACS chemical biology", "date": "2020", "authors": "Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" } ], "reference": [ { "type": "PubMed", "id": "32119511", "url": "https://glygen.org/publication/PubMed/32119511" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.", "journal": "Science advances", "date": "2021", "authors": "Lee JH, Jomaa A, Chung S, Hwang Fu YH, Qian R, Sun X, Hsieh HH, Chandrasekar S, Bi X, Mattei S, Boehringer D, Weiss S, Ban N, Shan SO", "evidence": [ { "database": "UniProtKB", "id": "O76094", "url": "https://www.uniprot.org/uniprot/O76094" } ], "reference": [ { "type": "PubMed", "id": "34020957", "url": "https://glygen.org/publication/PubMed/34020957" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76094" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "The role of assembly in insulin's biosynthesis.", "journal": "Current opinion in structural biology", "date": "1998", "authors": "Dodson G, Steiner D", "evidence": [ { "database": "Reactome", "id": "R-HSA-1799339", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1799339" } ], "reference": [ { "type": "PubMed", "id": "9631292", "url": "https://glygen.org/publication/PubMed/9631292" } ] } ], "pathway": [ { "id": "hsa:6731", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6731", "resource": "KEGG Pathway" }, { "id": "R-HSA-1799339", "name": "SRP-dependent cotranslational protein targeting to membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1799339", "resource": "Reactome", "description": "SRP-dependent cotranslational protein targeting to membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AW91-1", "protein_name": "Signal recognition particle subunit SRP72", "gene_name": "Srp72", "tax_id": 10116, "organism": "Rattus norvegicus", 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