{ "uniprot_canonical_ac": "O76083-1", "uniprot_ac": "O76083", "uniprot_id": "PDE9A_HUMAN", "mass": { "chemical_mass": 68493.0, "monoisotopic_mass": 68493.0 }, "refseq": { "ac": "NP_001001567", "name": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b", "summary": "The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" }, "gene_names": [ { "name": "PDE9A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O76083", "id": "O76083" }, { "name": "HSPDE9A2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567", "id": "NP_001001567" }, { "name": "PDE9A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567", "id": "NP_001001567" } ], "protein_names": [ { "name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O76083" }, { "name": "3.1.4.35", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O76083" }, { "name": "CGMP-specific 3',5'-cyclic phosphodiesterase type 9; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; phosphodiesterase PDE9A21", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567", "id": "NP_001001567" }, { "name": "high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567", "id": "NP_001001567" } ], "function": [ { "annotation": "Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.", "evidence": [ { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" }, { "database": "PubMed", "id": "33787083", "url": "https://glygen.org/publication/PubMed/33787083" } ] }, { "annotation": "Identification and distribution of different variants produced by differential splicing of phosphodiesterase 9A mRNA.", "evidence": [ { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" }, { "database": "PubMed", "id": "12565835", "url": "https://glygen.org/publication/PubMed/12565835" } ] }, { "annotation": "Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" }, { "database": "PubMed", "id": "34016083", "url": "https://glygen.org/publication/PubMed/34016083" } ] }, { "annotation": "Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083#function" }, { "database": "PubMed", "id": "25799991", "url": "https://glygen.org/publication/PubMed/25799991" }, { "database": "PubMed", "id": "18757755", "url": "https://glygen.org/publication/PubMed/18757755" }, { "database": "UniProtKB", "id": "Q8QZV1", "url": "https://www.uniprot.org/uniprot/Q8QZV1#function" }, { "database": "PubMed", "id": "9624146", "url": "https://glygen.org/publication/PubMed/9624146" }, { "database": "PubMed", "id": "21483814", "url": "https://glygen.org/publication/PubMed/21483814" } ] }, { "annotation": "The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O76083", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O76083" } ], "glycoeffect": [], "start_pos": 69, "end_pos": 69, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "21", "chr_pos": "42687981", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A69", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] }, { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix uteri cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 312, "end_pos": 312, "sequence_org": "H", "sequence_mut": "A", "comment": "Completely abolishes catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "18757755", "url": "https://glygen.org/publication/PubMed/18757755" } ] }, { "start_pos": 356, "end_pos": 356, "sequence_org": "H", "sequence_mut": "A", "comment": "Reduces catalytic activity, but has no effect on substrate affinity.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "18757755", "url": "https://glygen.org/publication/PubMed/18757755" } ] }, { "start_pos": 425, "end_pos": 425, "sequence_org": "M", "sequence_mut": "A", "comment": "Induces a 2 fold change in inhibitory sensitivity by BAY-73-9961.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "20121115", "url": "https://glygen.org/publication/PubMed/20121115" } ] }, { "start_pos": 463, "end_pos": 463, "sequence_org": "I", "sequence_mut": "A", "comment": "Induces a 6-9 fold change in inhibitory sensitivity by BAY-73-9961.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "20121115", "url": "https://glygen.org/publication/PubMed/20121115" } ] }, { "start_pos": 466, "end_pos": 466, "sequence_org": "E", "sequence_mut": "A", "comment": "Decreased affinity and catalytic activity for cGMP and cAMP.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "21483814", "url": "https://glygen.org/publication/PubMed/21483814" } ] }, { "start_pos": 480, "end_pos": 480, "sequence_org": "L", "sequence_mut": "A", "comment": "Induces a 6-9 fold change in inhibitory sensitivity by BAY-73-9961.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "20121115", "url": "https://glygen.org/publication/PubMed/20121115" } ] }, { "start_pos": 484, "end_pos": 484, "sequence_org": "Y", "sequence_mut": "A", "comment": "Induces a 6-9 fold change in inhibitory sensitivity by BAY-73-9961.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "20121115", "url": "https://glygen.org/publication/PubMed/20121115" } ] }, { "start_pos": 501, "end_pos": 501, "sequence_org": "F", "sequence_mut": "A", "comment": "Induces a 2 fold change in inhibitory sensitivity by BAY-73-9961.", "evidence": [ { "database": 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} ] }, { "start_pos": 516, "end_pos": 516, "sequence_org": "F", "sequence_mut": "A", "comment": "Induces a dramatic change in inhibitory sensitivity by BAY-73-9961.", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "PubMed", "id": "20121115", "url": "https://glygen.org/publication/PubMed/20121115" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "75.28", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000160191", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000160191" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "61.04", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000160191", "url": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76083" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O76083", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76083" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-11", "url": "https://www.uniprot.org/uniprot/O76083-11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-12", "url": "https://www.uniprot.org/uniprot/O76083-12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-13", "url": "https://www.uniprot.org/uniprot/O76083-13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-14", "url": "https://www.uniprot.org/uniprot/O76083-14", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-15", "url": "https://www.uniprot.org/uniprot/O76083-15", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-16", "url": "https://www.uniprot.org/uniprot/O76083-16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-2", "url": "https://www.uniprot.org/uniprot/O76083-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-3", "url": "https://www.uniprot.org/uniprot/O76083-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-4", "url": "https://www.uniprot.org/uniprot/O76083-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-5", "url": "https://www.uniprot.org/uniprot/O76083-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-6", "url": "https://www.uniprot.org/uniprot/O76083-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-7", "url": "https://www.uniprot.org/uniprot/O76083-7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-8", "url": "https://www.uniprot.org/uniprot/O76083-8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O76083-9", "url": "https://www.uniprot.org/uniprot/O76083-9", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 593, "header": "sp|O76083-1|PDE9A_HUMAN Isoform 1 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "isoforms": [ { "isoform_ac": "O76083-1", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 593, "header": "sp|O76083-1|PDE9A_HUMAN Isoform 1 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000291539.11", "url": "https://www.ensembl.org/id/ENST00000291539.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000291539.6", "url": "https://www.ensembl.org/id/ENSP00000291539.6" } ] } }, { "isoform_ac": "O76083-10", "url": "", "sequence": { "sequence": "MTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 376, "header": "sp|O76083-10|PDE9A_HUMAN Isoform 10 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": {} }, { "isoform_ac": "O76083-11", "url": "", "sequence": { "sequence": "MDAFRRNTTISLLTTDDAMVSIDPTMPANSERAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 459, "header": "sp|O76083-11|PDE9A_HUMAN Isoform 11 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653867, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398229.7", "url": "https://www.ensembl.org/id/ENST00000398229.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000381285.3", "url": "https://www.ensembl.org/id/ENSP00000381285.3" } ] } }, { "isoform_ac": "O76083-12", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKEHDHLPADHRRRHGLHRPHHAREFRTHSVQSETCGHQATLRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 491, "header": "sp|O76083-12|PDE9A_HUMAN Isoform 12 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000335440.10", "url": "https://www.ensembl.org/id/ENST00000335440.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000335365.6", "url": "https://www.ensembl.org/id/ENSP00000335365.6" } ] } }, { "isoform_ac": "O76083-13", "url": "", "sequence": { "sequence": "MDAFRSTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 526, "header": "sp|O76083-13|PDE9A_HUMAN Isoform 13 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653867, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398232.7", "url": "https://www.ensembl.org/id/ENST00000398232.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000381287.3", "url": "https://www.ensembl.org/id/ENSP00000381287.3" } ] } }, { "isoform_ac": "O76083-14", "url": "", "sequence": { "sequence": "MDAFRRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 552, "header": "sp|O76083-14|PDE9A_HUMAN Isoform 14 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653867, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398225.7", "url": "https://www.ensembl.org/id/ENST00000398225.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000381281.3", "url": "https://www.ensembl.org/id/ENSP00000381281.3" } ] } }, { "isoform_ac": "O76083-15", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 567, "header": "sp|O76083-15|PDE9A_HUMAN Isoform 15 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000328862.10", "url": "https://www.ensembl.org/id/ENST00000328862.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000328699.6", "url": "https://www.ensembl.org/id/ENSP00000328699.6" } ] } }, { "isoform_ac": "O76083-16", "url": "", "sequence": { "sequence": "MSSFSIHHSVTCCFYLVRSHGRPTSTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 485, "header": "sp|O76083-16|PDE9A_HUMAN Isoform 16 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": {} }, { "isoform_ac": "O76083-2", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 533, "header": "sp|O76083-2|PDE9A_HUMAN Isoform 2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000335512.8", "url": "https://www.ensembl.org/id/ENST00000335512.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000335242.4", "url": "https://www.ensembl.org/id/ENSP00000335242.4" } ] } }, { "isoform_ac": "O76083-3", "url": "", "sequence": { "sequence": "MDAFRSTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 466, "header": "sp|O76083-3|PDE9A_HUMAN Isoform 3 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653867, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398224.3", "url": "https://www.ensembl.org/id/ENST00000398224.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000381280.3", "url": "https://www.ensembl.org/id/ENSP00000381280.3" } ] } }, { "isoform_ac": "O76083-4", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKHSVQSETCGHQATLRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 465, "header": "sp|O76083-4|PDE9A_HUMAN Isoform 4 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000349112.7", "url": "https://www.ensembl.org/id/ENST00000349112.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000344730.3", "url": "https://www.ensembl.org/id/ENSP00000344730.3" } ] } }, { "isoform_ac": "O76083-5", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERNELILYTSLRNLLFLPSKESWASHQHSVQSETCGHQATLRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 540, "header": "sp|O76083-5|PDE9A_HUMAN Isoform 5 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000380328.6", "url": "https://www.ensembl.org/id/ENST00000380328.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000369685.2", "url": "https://www.ensembl.org/id/ENSP00000369685.2" } ] } }, { "isoform_ac": "O76083-6", "url": "", "sequence": { "sequence": "MDAFRRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 492, "header": "sp|O76083-6|PDE9A_HUMAN Isoform 6 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653867, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398234.7", "url": "https://www.ensembl.org/id/ENST00000398234.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000381289.3", "url": "https://www.ensembl.org/id/ENSP00000381289.3" } ] } }, { "isoform_ac": "O76083-7", "url": "", "sequence": { "sequence": "MREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 386, "header": "sp|O76083-7|PDE9A_HUMAN Isoform 7 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": {} }, { "isoform_ac": "O76083-8", "url": "", "sequence": { "sequence": "MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRTPYKVRPVAIKQLSEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 507, "header": "sp|O76083-8|PDE9A_HUMAN Isoform 8 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653815, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398236.7", "url": "https://www.ensembl.org/id/ENST00000398236.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000381291.3", "url": "https://www.ensembl.org/id/ENSP00000381291.3" } ] } }, { "isoform_ac": "O76083-9", "url": "", "sequence": { "sequence": "MDAFRRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA", "length": 433, "header": "sp|O76083-9|PDE9A_HUMAN Isoform 9 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens OX=9606 GN=PDE9A PE=1 SV=1 CANONICAL=O76083-1" }, "locus": { "chromosome": "21", "start_pos": 42775290, "end_pos": 42653867, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000398227.7", "url": "https://www.ensembl.org/id/ENST00000398227.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000381283.3", "url": "https://www.ensembl.org/id/ENSP00000381283.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O76083", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76083" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [ { "start_pos": 379, "end_pos": 379, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "site_lbl": "Ser379" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2003", "authors": "Rentero C, Monfort A, Puigdomenech P", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" }, { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" } ], "reference": [ { "type": "PubMed", "id": "12565835", "url": "https://glygen.org/publication/PubMed/12565835" } ] }, { "title": "Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.", "journal": "Gene", "date": "2003", "authors": "Wang P, Wu P, Egan RW, Billah MM", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "14527714", "url": "https://glygen.org/publication/PubMed/14527714" } ] }, { "title": "Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Huai Qing, Wang Huanchen, Zhang Wei, Colman Robert W, Robinson Howard, Ke Hengming", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "15210993", "url": "https://glygen.org/publication/PubMed/15210993" } ] }, { "title": "Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line.", "journal": "Mol. Pharmacol.", "date": "2005", "authors": "Wunder Frank, Tersteegen Adrian, Rebmann Annegret, Erb Christina, Fahrig Thomas, Hendrix Martin", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "16150925", "url": "https://glygen.org/publication/PubMed/16150925" } ] }, { "title": "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.", "journal": "Blood", "date": "2007", "authors": "Antl M, von Bruhl ML, Eiglsperger C, Werner M, Konrad I, Kocher T, Wilm M, Hofmann F, Massberg S, Schlossmann J", "evidence": [ { "database": "Reactome", "id": "R-HSA-418457", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418457" } ], "reference": [ { "type": "PubMed", "id": "16990611", "url": "https://glygen.org/publication/PubMed/16990611" } ] }, { "title": "Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene.", "journal": "BMC Mol. Biol.", "date": "2006", "authors": "Rentero Carles, Puigdom\u00e8nech Pere", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "17090334", "url": "https://glygen.org/publication/PubMed/17090334" } ] }, { "title": "Structural basis for the catalytic mechanism of human phosphodiesterase 9.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Liu S, Mansour MN, Dillman KS, Perez JR, Danley DE, Aeed PA, Simons SP, Lemotte PK, Menniti FS", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "18757755", "url": "https://glygen.org/publication/PubMed/18757755" } ] }, { "title": "Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.", "journal": "J. Med. Chem.", "date": "2009", "authors": "Verhoest PR, Proulx-Lafrance C, Corman M, Chenard L, Helal CJ, Hou X, Kleiman R, Liu S, Marr E, Menniti FS, Schmidt CJ, Vanase-Frawley M, Schmidt AW, Williams RD, Nelson FR, Fonseca KR, Liras S", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "19919087", "url": "https://glygen.org/publication/PubMed/19919087" } ] }, { "title": "Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis.", "journal": "Journal of medicinal chemistry", "date": "2010", "authors": "Wang H, Luo X, Ye M, Hou J, Robinson H, Ke H", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "20121115", "url": "https://glygen.org/publication/PubMed/20121115" } ] }, { "title": "Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine.", "journal": "PloS one", "date": "2011", "authors": "Hou J, Xu J, Liu M, Zhao R, Luo HB, Ke H", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "21483814", "url": "https://glygen.org/publication/PubMed/21483814" } ] }, { "title": "Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.", "journal": "J. Pharmacol. Exp. Ther.", "date": "2012", "authors": "Kleiman RJ, Chapin DS, Christoffersen C, Freeman J, Fonseca KR, Geoghegan KF, Grimwood S, Guanowsky V, Hajos M, Harms JF, Helal CJ, Hoffmann WE, Kocan GP, Majchrzak MJ, McGinnis D, McLean S, Menniti FS, Nelson F, Roof R, Schmidt AW, Seymour PA, Stephenson DT, Tingley FD, Vanase-Frawley M, Verhoest PR, Schmidt CJ", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "22328573", "url": "https://glygen.org/publication/PubMed/22328573" } ] }, { "title": "Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.", "journal": "J. Med. Chem.", "date": "2012", "authors": "Meng F, Hou J, Shao YX, Wu PY, Huang M, Zhu X, Cai Y, Li Z, Xu J, Liu P, Luo HB, Wan Y, Ke H", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "22985069", "url": "https://glygen.org/publication/PubMed/22985069" } ] }, { "title": "Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.", "journal": "J. Med. Chem.", "date": "2012", "authors": "Claffey MM, Helal CJ, Verhoest PR, Kang Z, Fors KS, Jung S, Zhong J, Bundesmann MW, Hou X, Lui S, Kleiman RJ, Vanase-Frawley M, Schmidt AW, Menniti F, Schmidt CJ, Hoffman WE, Hajos M, McDowell L, O'Connor RE, Macdougall-Murphy M, Fonseca KR, Becker SL, Nelson FR, Liras S", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "23025719", "url": "https://glygen.org/publication/PubMed/23025719" } ] }, { "title": "Phosphodiesterase 9: insights from protein structure and role in therapeutics.", "journal": "Life Sci.", "date": "2014", "authors": "Singh Nivedita, Patra Sanjukta", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "24746902", "url": "https://glygen.org/publication/PubMed/24746902" } ] }, { "title": "Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.", "journal": "Nature", "date": "2015", "authors": "Lee DI, Zhu G, Sasaki T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "25799991", "url": "https://glygen.org/publication/PubMed/25799991" } ] }, { "title": "Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.", "journal": "ESC heart failure", "date": "2021", "authors": "Besler C, Rommel KP, Kresoja KP, Morbitz J, Kirsten H, Scholz M, Klingel K, Thiery J, Burkhardt R, Buttner P, Adams V, Thiele H, Lurz P", "evidence": [ { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" } ], "reference": [ { "type": "PubMed", "id": "33787083", "url": "https://glygen.org/publication/PubMed/33787083" } ] }, { "title": "Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.", "journal": "BMC cancer", "date": "2021", "authors": "Susmi TF, Rahman A, Khan MMR, Yasmin F, Islam MS, Nasif O, Alharbi SA, Batiha GE, Hossain MU", "evidence": [ { "database": "RefSeq", "id": "NP_001001567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001567" } ], "reference": [ { "type": "PubMed", "id": "34016083", "url": "https://glygen.org/publication/PubMed/34016083" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O76083", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O76083" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K", "evidence": [ { "database": "Reactome", "id": "R-HSA-418457", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418457" } ], "reference": [ { "type": "PubMed", "id": "8557689", "url": "https://glygen.org/publication/PubMed/8557689" } ] }, { "title": "Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "9624146", "url": "https://glygen.org/publication/PubMed/9624146" } ] }, { "title": "Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence.", "journal": "Hum. Genet.", "date": "1998", "authors": "Guipponi M, Scott H S, Kudoh J, Kawasaki K, Shibuya K, Shintani A, Asakawa S, Chen H, Lalioti M D, Rossier C, Minoshima S, Shimizu N, Antonarakis S E", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "reference": [ { "type": "PubMed", "id": "9856478", "url": "https://glygen.org/publication/PubMed/9856478" } ] } ], "pathway": [ { "id": "hsa:5152", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5152", "resource": "KEGG Pathway" }, { "id": "R-HSA-418457", "name": "cGMP effects", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418457", "resource": "Reactome", "description": "cGMP effects" } ], "orthologs": [ { "uniprot_canonical_ac": "O70628-1", "protein_name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "gene_name": "Pde9a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELIQGVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARNSRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRNNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPVVEETMLRPLWESREHYEELKQLDDAMKELQKKTESLTSGAPENTTEKNRDAKDSEGHSPPN", "length": 534 }, "evidence": [ { "id": "45928551", "url": "http://www.informatics.jax.org/homology/45928551", "database": "MGI" }, { "id": "O76083", "url": "https://omabrowser.org/oma/group/O76083/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8QZV1-1", "protein_name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "gene_name": "Pde9a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGAGSSSYRPKAIYLDIDGRIQKVVFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAVKQVSEREELVQGVLAQVAEQFSRAFKINELKAEVANHLAMLEKRVELEGLKVVEIEKCKSDIKKMREELAARNNRTNCPCKYSFLDNKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYRSNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPIVEETMLRPLWESREHYEELKQLDDAMKELQKKTENLTSGATENAPEKTRDAKDNEDRSPPN", "length": 534 }, "evidence": [ { "id": "45928551", "url": "http://www.informatics.jax.org/homology/45928551", "database": "MGI" }, { "id": "O76083", "url": "https://omabrowser.org/oma/group/O76083/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "perikaryon", "id": "GO:0043204", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043204", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "sarcolemma", "id": "GO:0042383", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "ruffle membrane", "id": "GO:0032587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032587", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "positive regulation of long-term synaptic potentiation", "id": "GO:1900273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900273", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "positive regulation of cardiac muscle hypertrophy", "id": "GO:0010613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010613", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "negative regulation of neural precursor cell proliferation", "id": "GO:2000178", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000178", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "cGMP metabolic process", "id": "GO:0046068", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046068", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "cGMP catabolic process", "id": "GO:0046069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046069", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "3',5'-cyclic-GMP phosphodiesterase activity", "id": "GO:0047555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047555", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" }, { "name": "3',5'-cyclic-nucleotide phosphodiesterase activity", "id": "GO:0004114", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004114", "evidence": [ { "database": "UniProtKB", "id": "O76083", "url": "https://www.uniprot.org/uniprot/O76083" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 360, "end_pos": 362, "annotation": "n_glycosylation_sequon" }, { "start_pos": 48, "end_pos": 50, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16957", "name": "", "equation": "3',5'-cyclic GMP + H2O = GMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VID6-1", "P61250-1", "O54735-1", "Q8QZV1-1", "M0R4R9-1", "Q9QYJ6-1", "Q63421-1", "A0A8I6A416-1", "Q01066-1", "Q62865-1", "Q01062-1", "Q63085-1", "P18545-1", "Q13956-1", "O76083-1", "P51160-1", "P16499-1", "Q9HCR9-1", "O76074-1", "P35913-1", "Q9Y233-3", "Q14123-1", "O00408-1", "Q13370-1", "P54750-1", "Q01064-1", "Q14432-1", "Q01065-1", "P09174-1", "P61249-1", "Q91ZQ1-1", "P27664-1", "P23440-1", "Q8CG03-1", "O70628-1", "P0C1Q2-1", "Q8CA95-1", "Q61481-4", "Q61409-1", "Q9Z0X4-1", "Q922S4-1", "Q64338-3", "B0G0Y8-1", "P12019-1", "Q54HY0-1", "Q8MLZ3-1", "Q8MM62-1", "B7YZV4-1", "Q9I7S6-1", "Q9VFI9-1", "Q9VJ79-1" ], "evidence": [ { "id": "16957", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16957" } ] }, { "id": "R-HSA-418456", "name": "cGMP is degraded by PDEs", "equation": "", "summary": "Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O76074-1", "O00408-1", "O76083-1", "P54750-1", "Q01064-1", "Q9Y233-3", "Q9HCR9-1" ], "evidence": [ { "id": "R-HSA-418456", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418456" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6A416", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A8I6A416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A416" } ] } ] }, { "uniprot_ac": "B0G0Y8", "gene_name": "pde3", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "B0G0Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "B0G0Y8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y8" } ] } ] }, { "uniprot_ac": "B7YZV4", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] } ] }, { "uniprot_ac": "M0R4R9", "gene_name": "Pde6g", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "M0R4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4R9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "M0R4R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4R9" } ] } ] }, { "uniprot_ac": "O00408", "gene_name": "PDE2A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] } ] }, { "uniprot_ac": "O54735", "gene_name": "Pde5a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O54735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54735" } ] } ] }, { "uniprot_ac": "O70628", "gene_name": "Pde9a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O70628", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70628" } ] } ] }, { "uniprot_ac": "O76074", "gene_name": "PDE5A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O76074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76074" } ] } ] }, { "uniprot_ac": "O76083", "gene_name": "PDE9A", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "O76083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76083" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "O76083", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76083" } ] } ] }, { "uniprot_ac": "P09174", "gene_name": "Pde6g", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P09174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09174" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P09174", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09174" } ] } ] }, { "uniprot_ac": "P0C1Q2", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] } ] }, { "uniprot_ac": "P12019", "gene_name": "pdsA", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] } ] }, { "uniprot_ac": "P16499", "gene_name": "PDE6A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P16499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16499" } ] } ] }, { "uniprot_ac": "P18545", "gene_name": "PDE6G", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P18545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18545" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P18545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18545" } ] } ] }, { "uniprot_ac": "P23440", "gene_name": "Pde6b", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P23440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23440" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P23440", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23440" } ] } ] }, { "uniprot_ac": "P27664", "gene_name": "Pde6a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P27664", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27664" } ] } ] }, { "uniprot_ac": "P35913", "gene_name": "PDE6B", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P35913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35913" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P35913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35913" } ] } ] }, { "uniprot_ac": "P51160", "gene_name": "PDE6C", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P51160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51160" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P51160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51160" } ] } ] }, { "uniprot_ac": "P54750", "gene_name": "PDE1A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] } ] }, { "uniprot_ac": "P61249", "gene_name": "Pde6h", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P61249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61249" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P61249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61249" } ] } ] }, { "uniprot_ac": "P61250", "gene_name": "Pde6h", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P61250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61250" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P61250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61250" } ] } ] }, { "uniprot_ac": "Q01062", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] } ] }, { "uniprot_ac": "Q01064", "gene_name": "PDE1B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] } ] }, { "uniprot_ac": "Q01065", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] } ] }, { "uniprot_ac": "Q01066", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] } ] }, { "uniprot_ac": "Q13370", "gene_name": "PDE3B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] } ] }, { "uniprot_ac": "Q13956", "gene_name": "PDE6H", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q13956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13956" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q13956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13956" } ] } ] }, { "uniprot_ac": "Q14123", "gene_name": "PDE1C", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] } ] }, { "uniprot_ac": "Q14432", "gene_name": "PDE3A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q14432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14432" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q14432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14432" } ] } ] }, { "uniprot_ac": "Q54HY0", "gene_name": "pde7", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] } ] }, { "uniprot_ac": "Q61409", "gene_name": "Pde3b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] } ] }, { "uniprot_ac": "Q61481", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q61481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61481" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q61481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61481" } ] } ] }, { "uniprot_ac": "Q62865", "gene_name": "Pde3a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q62865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62865" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q62865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62865" } ] } ] }, { "uniprot_ac": "Q63085", "gene_name": "Pde3b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] } ] }, { "uniprot_ac": "Q63421", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] } ] }, { "uniprot_ac": "Q64338", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q64338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64338" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q64338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64338" } ] } ] }, { "uniprot_ac": "Q8CA95", "gene_name": "Pde10a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] } ] }, { "uniprot_ac": "Q8CG03", "gene_name": "Pde5a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8CG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CG03" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8CG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CG03" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8CG03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CG03" } ] } ] }, { "uniprot_ac": "Q8MLZ3", "gene_name": "pdeD", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8MLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MLZ3" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8MLZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MLZ3" } ] } ] }, { "uniprot_ac": "Q8MM62", "gene_name": "pdeE", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] } ] }, { "uniprot_ac": "Q8QZV1", "gene_name": "Pde9a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8QZV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV1" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8QZV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV1" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8QZV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8QZV1" } ] } ] }, { "uniprot_ac": "Q8VID6", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] } ] }, { "uniprot_ac": "Q91ZQ1", "gene_name": "Pde6c", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q91ZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZQ1" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q91ZQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZQ1" } ] } ] }, { "uniprot_ac": "Q922S4", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] } ] }, { "uniprot_ac": "Q9HCR9", "gene_name": "PDE11A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] } ] }, { "uniprot_ac": "Q9I7S6", "gene_name": "Pde9", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9I7S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S6" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9I7S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S6" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9I7S6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7S6" } ] } ] }, { "uniprot_ac": "Q9QYJ6", "gene_name": "Pde10a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] } ] }, { "uniprot_ac": "Q9VFI9", "gene_name": "Pde6", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9VFI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFI9" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9VFI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFI9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9VFI9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFI9" } ] } ] }, { "uniprot_ac": "Q9VJ79", "gene_name": "Pde11", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] } ] }, { "uniprot_ac": "Q9Y233", "gene_name": "PDE10A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9Y233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y233" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9Y233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y233" } ] } ] }, { "uniprot_ac": "Q9Z0X4", "gene_name": "Pde3a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9Z0X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0X4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9Z0X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0X4" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 69 ], "glycation_sites": [], "phosphorylation_sites": [ 379 ], "sequon_annotation_sites": [ { "start_pos": 31, "end_pos": 33 }, { "start_pos": 360, "end_pos": 362 }, { "start_pos": 48, "end_pos": 50 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", 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