{
"uniprot_canonical_ac": "O76074-1",
"uniprot_ac": "O76074",
"uniprot_id": "PDE5A_HUMAN",
"mass": {
"chemical_mass": 99985.0,
"monoisotopic_mass": 99985.0
},
"refseq": {
"ac": "NP_001074",
"name": "cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1",
"summary": "This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074"
},
"gene_names": [
{
"name": "PDE5A",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O76074",
"id": "O76074"
},
{
"name": "CGB-PDE; CN5A; PDE5",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074",
"id": "NP_001074"
},
{
"name": "PDE5A",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074",
"id": "NP_001074"
},
{
"name": "PDE5",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O76074",
"id": "O76074"
},
{
"name": "hCG_38154",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O76074",
"id": "O76074"
}
],
"protein_names": [
{
"name": "cGMP-specific 3',5'-cyclic phosphodiesterase",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O76074"
},
{
"name": "3.1.4.35",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O76074"
},
{
"name": "CGB-PDE",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O76074"
},
{
"name": "cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-specific phosphodiesterase type 5A; phosphodiesterase isozyme 5; cGMP-specific phosphodiesterase PDE5A2; phosphodiesterase 5A, cGMP-specific",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074",
"id": "NP_001074"
},
{
"name": "cGMP-binding cGMP-specific phosphodiesterase",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O76074"
},
{
"name": "cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074",
"id": "NP_001074"
}
],
"function": [
{
"annotation": "Cellular Redox Metabolism Is Modulated by the Distinct Localization of Cyclic Nucleotide Phosphodiesterase 5A Isoforms. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001074",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074"
},
{
"database": "PubMed",
"id": "35955722",
"url": "https://glygen.org/publication/PubMed/35955722"
}
]
},
{
"annotation": "Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001074",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074"
},
{
"database": "PubMed",
"id": "34424768",
"url": "https://glygen.org/publication/PubMed/34424768"
}
]
},
{
"annotation": "LncRNA ARAP1-AS1 targets miR-516b-5p/PDE5A axis to facilitate the progression of thyroid cancer.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001074",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074"
},
{
"database": "PubMed",
"id": "36730555",
"url": "https://glygen.org/publication/PubMed/36730555"
}
]
},
{
"annotation": "Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074#function"
},
{
"database": "PubMed",
"id": "9714779",
"url": "https://glygen.org/publication/PubMed/9714779"
}
]
},
{
"annotation": "This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001074",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "O76074",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O76074"
}
],
"glycoeffect": [],
"start_pos": 489,
"end_pos": 489,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "E",
"sequence_mut": "K",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).",
"chr_id": "4",
"chr_pos": "119542566",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "E489",
"disease": [
{
"disease_id": "DOID:1793",
"recommended_name": {
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic cancer",
"description": "An endocrine gland cancer located_in the pancreas."
},
"synonyms": [
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca body of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca head of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca tail of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of body of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of head of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of tail of pancreas",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreas neoplasm",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic neoplasm",
"description": ""
},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic tumor",
"description": ""
}
]
},
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:1319",
"recommended_name": {
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain cancer",
"description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain."
},
"synonyms": [
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "BT - Brain tumour",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "adult brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "adult malignant brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm, adult",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant brain tumour",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant primary brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant primary brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of Brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of adult brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain tumor",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary malignant neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "tumor of the Brain",
"description": ""
}
]
},
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "O76074",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O76074"
}
],
"glycoeffect": [],
"start_pos": 577,
"end_pos": 577,
"subjects_tested": "0",
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"frequency": "0.0",
"sequence_org": "R",
"sequence_mut": "W",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).",
"chr_id": "4",
"chr_pos": "119525599",
"ref_nt": "G",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "R577",
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
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"name": "malignant tumour of large bowel",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
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},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
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},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
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}
]
},
{
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"id": "DOID:363",
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"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
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},
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{
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"url": "http://disease-ontology.org/term/DOID:363",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
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"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
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},
{
"id": "DOID:363",
"resource": "Disease Ontology",
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"name": "uterus neoplasm",
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}
]
},
{
"disease_id": "DOID:1793",
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"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreatic cancer",
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},
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{
"id": "DOID:1793",
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},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca head of pancreas",
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},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "Ca tail of pancreas",
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},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of body of pancreas",
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},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of head of pancreas",
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},
{
"id": "DOID:1793",
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"url": "http://disease-ontology.org/term/DOID:1793",
"name": "malignant neoplasm of tail of pancreas",
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},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1793",
"name": "pancreas neoplasm",
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},
{
"id": "DOID:1793",
"resource": "Disease Ontology",
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},
{
"id": "DOID:1793",
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"url": "http://disease-ontology.org/term/DOID:1793",
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}
]
},
{
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"url": "http://disease-ontology.org/term/DOID:11934",
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{
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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}
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}
],
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},
{
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],
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"end_pos": 77,
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{
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{
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{
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},
{
"id": "MONDO:0012942",
"resource": "MONDO",
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{
"id": "MONDO:0012942",
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{
"id": "MONDO:0012942",
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{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
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{
"id": "MONDO:0012955",
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"name": "lung cancer susceptibility 4",
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},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
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},
{
"id": "MONDO:0013631",
"resource": "MONDO",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
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"name": "lung cancer, somatic",
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},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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"description": ""
},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"name": "malignant lung tumor",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MONDO:0008903",
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"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
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"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
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},
{
"id": "MONDO:0008903",
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},
{
"id": "MIM:211980",
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]
},
{
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},
{
"id": "DOID:1319",
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"url": "http://disease-ontology.org/term/DOID:1319",
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},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
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"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm",
"description": ""
},
{
"id": "DOID:1319",
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"url": "http://disease-ontology.org/term/DOID:1319",
"name": "brain neoplasm, adult",
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},
{
"id": "DOID:1319",
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},
{
"id": "DOID:1319",
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},
{
"id": "DOID:1319",
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},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of Brain",
"description": ""
},
{
"id": "DOID:1319",
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"url": "http://disease-ontology.org/term/DOID:1319",
"name": "malignant tumor of adult brain",
"description": ""
},
{
"id": "DOID:1319",
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"url": "http://disease-ontology.org/term/DOID:1319",
"name": "neoplasm of brain",
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},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain neoplasm",
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},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary brain tumor",
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},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "primary malignant neoplasm of brain",
"description": ""
},
{
"id": "DOID:1319",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1319",
"name": "tumor of the Brain",
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}
]
},
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
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},
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{
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},
{
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},
{
"id": "MONDO:0007576",
"resource": "MONDO",
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"name": "malignant tumour of distal third of oesophagus",
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},
{
"id": "MONDO:0007576",
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"url": "https://monarchinitiative.org/disease/MONDO:0007576",
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},
{
"id": "MONDO:0007576",
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},
{
"id": "MONDO:0007576",
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},
{
"id": "MONDO:0007576",
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},
{
"id": "MONDO:0007576",
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},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
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},
{
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}
]
},
{
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},
{
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},
{
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},
{
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]
}
],
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}
],
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{
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{
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]
},
{
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{
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],
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{
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{
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},
{
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{
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},
{
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},
{
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},
{
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{
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{
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},
{
"tissue": {
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},
{
"tissue": {
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]
},
{
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},
{
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]
}
],
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{
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{
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],
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},
{
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},
{
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},
{
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},
{
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{
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},
{
"id": "MONDO:0012597",
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{
"id": "MONDO:0012597",
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{
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{
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{
"id": "MONDO:0012741",
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},
{
"id": "MONDO:0012741",
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},
{
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{
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{
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},
{
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},
{
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"name": "prostate cancer, hereditary, 5",
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},
{
"id": "MONDO:0012244",
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{
"id": "MONDO:0012244",
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},
{
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{
"id": "MONDO:0012093",
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},
{
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},
{
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{
"id": "MONDO:0012093",
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},
{
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},
{
"id": "MONDO:0012094",
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},
{
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},
{
"id": "MONDO:0012094",
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"name": "prostate cancer, susceptibility to, 4",
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{
"id": "MONDO:0012094",
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},
{
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},
{
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},
{
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"name": "MSMB familial prostate cancer",
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},
{
"id": "MONDO:0012758",
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"name": "familial prostate cancer caused by mutation in MSMB",
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},
{
"id": "MONDO:0012758",
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"name": "prostate cancer, hereditary, 13",
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},
{
"id": "MONDO:0012758",
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"description": ""
},
{
"id": "MONDO:0012758",
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},
{
"id": "MONDO:0011270",
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"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
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},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
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"name": "HPC8",
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},
{
"id": "MONDO:0011270",
"resource": "MONDO",
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"name": "predisposing for prostate cancer",
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},
{
"id": "MONDO:0011270",
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"name": "prostate cancer, susceptibility to",
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},
{
"id": "MONDO:0012300",
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"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
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"name": "prostate cancer, hereditary, 6",
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},
{
"id": "MONDO:0012300",
"resource": "MONDO",
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"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
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"name": "prostate cancer, susceptibility to",
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},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
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}
],
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{
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"synonyms": [
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},
{
"id": "DOID:10534",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "ca greater curvature of stomach",
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},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
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},
{
"id": "DOID:11054",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
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},
{
"id": "MONDO:0001187",
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"name": "malignant urinary bladder neoplasm",
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},
{
"id": "MONDO:0001187",
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"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
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"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
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"name": "urinary bladder malignant neoplasm",
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},
{
"id": "MONDO:0001187",
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"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
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},
{
"id": "MIM:109800",
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"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
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"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76074"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76074"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76074"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76074"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76074"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O76074",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O76074"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
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},
{
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},
{
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},
{
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},
{
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{
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{
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}
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},
{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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{
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"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "positive regulation of cardiac muscle hypertrophy",
"id": "GO:0010613",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010613",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "relaxation of cardiac muscle",
"id": "GO:0055119",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055119",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "oocyte development",
"id": "GO:0048599",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048599",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "T cell proliferation",
"id": "GO:0042098",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042098",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "cGMP catabolic process",
"id": "GO:0046069",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046069",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "regulation of nitric oxide mediated signal transduction",
"id": "GO:0010749",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010749",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 1,
"go_terms": [
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 4,
"go_terms": [
{
"name": "metal ion binding",
"id": "GO:0046872",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "cGMP binding",
"id": "GO:0030553",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030553",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "3',5'-cyclic-GMP phosphodiesterase activity",
"id": "GO:0047555",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047555",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
},
{
"name": "3',5'-cyclic-nucleotide phosphodiesterase activity",
"id": "GO:0004114",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004114",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 661,
"end_pos": 663,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation.",
"evidence": [
{
"database": "UniProtKB",
"id": "O76074",
"url": "https://www.uniprot.org/uniprot/O76074"
},
{
"database": "PubMed",
"id": "11723116",
"url": "https://glygen.org/publication/PubMed/11723116"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "16957",
"name": "",
"equation": "3',5'-cyclic GMP + H2O = GMP + H(+)",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q8VID6-1",
"P61250-1",
"O54735-1",
"Q8QZV1-1",
"M0R4R9-1",
"Q9QYJ6-1",
"Q63421-1",
"A0A8I6A416-1",
"Q01066-1",
"Q62865-1",
"Q01062-1",
"Q63085-1",
"P18545-1",
"Q13956-1",
"O76083-1",
"P51160-1",
"P16499-1",
"Q9HCR9-1",
"O76074-1",
"P35913-1",
"Q9Y233-3",
"Q14123-1",
"O00408-1",
"Q13370-1",
"P54750-1",
"Q01064-1",
"Q14432-1",
"Q01065-1",
"P09174-1",
"P61249-1",
"Q91ZQ1-1",
"P27664-1",
"P23440-1",
"Q8CG03-1",
"O70628-1",
"P0C1Q2-1",
"Q8CA95-1",
"Q61481-4",
"Q61409-1",
"Q9Z0X4-1",
"Q922S4-1",
"Q64338-3",
"B0G0Y8-1",
"P12019-1",
"Q54HY0-1",
"Q8MLZ3-1",
"Q8MM62-1",
"B7YZV4-1",
"Q9I7S6-1",
"Q9VFI9-1",
"Q9VJ79-1"
],
"evidence": [
{
"id": "16957",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/16957"
}
]
},
{
"id": "R-HSA-418456",
"name": "cGMP is degraded by PDEs",
"equation": "",
"summary": "Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.
PDE2, 3 and 5 are expressed in platelets.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O76074-1",
"O00408-1",
"O76083-1",
"P54750-1",
"Q01064-1",
"Q9Y233-3",
"Q9HCR9-1"
],
"evidence": [
{
"id": "R-HSA-418456",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418456"
}
]
},
{
"id": "R-HSA-9018778",
"name": "RHOBTB1 binds interacting proteins at the endosome membrane",
"equation": "",
"summary": "RHOBTB1, like the other member of the RHOBTB family, RHOBTB2, as well as the divergent RHOBTB3, which does not belong to the RHO superfamily, binds to CUL3 (cullin-3), a core component of the BTB-CUL3-RBX2 E3 ubiquitin ligase complex (Berthold et al. 2008). RHOBTB1 binds to ROCK1 and ROCK2, and ROCK-mediated phosphorylation of RHOBTB1 may regulate its association with CUL3 (Haga et al. 2019). RHOBTB1 has been proposed as a substrate adaptor for PDE5, targeting it to CUL3 complexes for ubiquitination (Mukohda et al. 2019).
Candidate RHOBTB1 interactors identified in the screen conducted by Bagci et al. 2020 include:
CCT2 (Bagci et al. 2020)
CCT7 (Bagci et al. 2020)
COPS2 (Bagci et al. 2020)
COPS4 (Bagci et al. 2020)
CPSF7 (Bagci et al. 2020)
DBN1 (Bagci et al. 2020)
GPS1 (Bagci et al. 2020)
HNRNPC (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
RBBP6 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
RNF20 (Bagci et al. 2020)
SPEN (Bagci et al. 2020)
SRRM1 (Bagci et al. 2020)
STK38 (Bagci et al. 2020)
TRA2B (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VIM (Bagci et al. 2020)
Some of the candidate interactors, like CCT2 and CCT7, are part of the CCT chaperone complex, while others (DBN1 and MYO6) are related to the actin cytoskeleton, RNA splicing and export (HNRNPC, RBMX and SRRM1) or COP9 signalosome (COPS2 and COPS4).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O76074-1",
"O75116-1",
"Q5VTR2-1",
"Q15208-1",
"Q7Z6E9-1"
],
"evidence": [
{
"id": "R-HSA-9018778",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018778"
}
]
},
{
"id": "R-HSA-9708104",
"name": "PDE5A dimer binds PDE5A inhibitors",
"equation": "",
"summary": "The cGMP-specific phosphodiesterase PDE5A is highly expressed in vascular and bronchial smooth muscle, in renal tubules and in platelets. It is prominent in the retina and the corpus cavernosa, the pair of erectile tissues in the penis. It catalyses the degradation of cGMP in these tissues, facilitating muscle contraction. Clinically used PDE5A inhibitors target PDE5A in vascular muscle to treat erectile dysfunction (Ventimiglia et al. 2016, Gong et al. 2017) and bronchial smooth muscle to treat pulmonary arterial hypertension (Palacios et al. 2020).
Erectile dysfunction drugs such as Viagra (sildenafil), Cialis (tadalafil) and Levitra (vardenafil) inhibit PDE5A (Boolell et al. 1996, Ballard et al. 1998, Moreland et al. 1998), increasing cGMP levels and thereby allowing smooth muscle relaxation and vasodilation. This allows blood flow into the corpus cavernosa leading to erection (Raheem & Kell 2009).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"O76074-1"
],
"evidence": [
{
"id": "R-HSA-9708104",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9708104"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "A0A8I6A416",
"gene_name": "Pde1a",
"activity": [
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "A0A8I6A416",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A8I6A416"
}
]
}
]
},
{
"uniprot_ac": "B0G0Y8",
"gene_name": "pde3",
"activity": [
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "B0G0Y8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G0Y8"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "B0G0Y8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B0G0Y8"
}
]
}
]
},
{
"uniprot_ac": "B7YZV4",
"gene_name": "Pde1c",
"activity": [
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "B7YZV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B7YZV4"
}
]
},
{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
"evidence": [
{
"id": "B7YZV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B7YZV4"
}
]
},
{
"ec_number": "3.1.4.17",
"activity": "",
"evidence": [
{
"id": "B7YZV4",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/B7YZV4"
}
]
}
]
},
{
"uniprot_ac": "M0R4R9",
"gene_name": "Pde6g",
"activity": [
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "M0R4R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0R4R9"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "M0R4R9",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/M0R4R9"
}
]
}
]
},
{
"uniprot_ac": "O00408",
"gene_name": "PDE2A",
"activity": [
{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
"evidence": [
{
"id": "O00408",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00408"
}
]
},
{
"ec_number": "3.1.4.17",
"activity": "",
"evidence": [
{
"id": "O00408",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00408"
}
]
},
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "O00408",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00408"
}
]
}
]
},
{
"uniprot_ac": "O54735",
"gene_name": "Pde5a",
"activity": [
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "O54735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54735"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "O54735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54735"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "O54735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O54735"
}
]
}
]
},
{
"uniprot_ac": "O70628",
"gene_name": "Pde9a",
"activity": [
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "O70628",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70628"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "O70628",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70628"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "O70628",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O70628"
}
]
}
]
},
{
"uniprot_ac": "O75116",
"gene_name": "ROCK2",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O75116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75116"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O75116",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75116"
}
]
}
]
},
{
"uniprot_ac": "O76074",
"gene_name": "PDE5A",
"activity": [
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "O76074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76074"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "O76074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76074"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "O76074",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76074"
}
]
}
]
},
{
"uniprot_ac": "O76083",
"gene_name": "PDE9A",
"activity": [
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "O76083",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76083"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "O76083",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O76083"
}
]
}
]
},
{
"uniprot_ac": "P09174",
"gene_name": "Pde6g",
"activity": [
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "P09174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09174"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "P09174",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P09174"
}
]
}
]
},
{
"uniprot_ac": "P0C1Q2",
"gene_name": "Pde11a",
"activity": [
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "P0C1Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1Q2"
}
]
},
{
"ec_number": "3.1.4.53",
"activity": "3',5'-cyclic AMP + H2O = AMP + H(+).",
"evidence": [
{
"id": "P0C1Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1Q2"
}
]
},
{
"ec_number": "3.1.4.53",
"activity": "",
"evidence": [
{
"id": "P0C1Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1Q2"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "P0C1Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1Q2"
}
]
},
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "P0C1Q2",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P0C1Q2"
}
]
}
]
},
{
"uniprot_ac": "P12019",
"gene_name": "pdsA",
"activity": [
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "P12019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12019"
}
]
},
{
"ec_number": "3.1.4.53",
"activity": "3',5'-cyclic AMP + H2O = AMP + H(+).",
"evidence": [
{
"id": "P12019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12019"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "P12019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12019"
}
]
},
{
"ec_number": "3.1.4.53",
"activity": "",
"evidence": [
{
"id": "P12019",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12019"
}
]
}
]
},
{
"uniprot_ac": "P16499",
"gene_name": "PDE6A",
"activity": [
{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "P16499",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16499"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "3',5'-cyclic GMP + H2O = GMP + H(+).",
"evidence": [
{
"id": "P16499",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16499"
}
]
},
{
"ec_number": "3.1.4.35",
"activity": "",
"evidence": [
{
"id": "P16499",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16499"
}
]
}
]
},
{
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}
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{
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}
]
}
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},
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}
]
},
{
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}
]
}
]
},
{
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"ec_number": "3.1.4.35",
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}
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},
{
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}
]
},
{
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}
]
}
]
},
{
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{
"ec_number": "3.1.4.35",
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}
]
},
{
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}
]
}
]
},
{
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{
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}
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},
{
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}
]
}
]
},
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}
]
},
{
"ec_number": "3.1.4.17",
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}
]
}
]
},
{
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{
"ec_number": "3.1.4.35",
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}
]
},
{
"ec_number": "3.1.4.35",
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]
}
]
},
{
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"ec_number": "3.1.4.35",
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}
]
},
{
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}
]
}
]
},
{
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{
"ec_number": "3.1.4.-",
"activity": "",
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}
]
},
{
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]
},
{
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}
]
}
]
},
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"ec_number": "3.1.4.17",
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},
{
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},
{
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}
]
}
]
},
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"ec_number": "3.1.4.-",
"activity": "",
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}
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},
{
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},
{
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]
}
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"ec_number": "3.1.4.17",
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]
},
{
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]
},
{
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]
}
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},
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]
},
{
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]
}
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},
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]
},
{
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]
}
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},
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]
},
{
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]
}
]
},
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{
"ec_number": "3.1.4.-",
"activity": "",
"evidence": [
{
"id": "Q14123",
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}
]
},
{
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"id": "Q14123",
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]
},
{
"ec_number": "3.1.4.17",
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"evidence": [
{
"id": "Q14123",
"database": "UniProtKB",
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}
]
}
]
},
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{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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{
"id": "Q14432",
"database": "UniProtKB",
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]
},
{
"ec_number": "3.1.4.17",
"activity": "",
"evidence": [
{
"id": "Q14432",
"database": "UniProtKB",
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]
}
]
},
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{
"ec_number": "2.7.11.1",
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{
"id": "Q15208",
"database": "UniProtKB",
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]
},
{
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{
"id": "Q15208",
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]
}
]
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"ec_number": "3.1.4.35",
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"id": "Q54HY0",
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]
},
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"id": "Q54HY0",
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]
},
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{
"id": "Q54HY0",
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}
]
},
{
"ec_number": "3.1.4.35",
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{
"id": "Q54HY0",
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}
]
}
]
},
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{
"ec_number": "2.3.2.27",
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]
},
{
"ec_number": "2.3.2.27",
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{
"id": "Q5VTR2",
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]
}
]
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{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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]
},
{
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"id": "Q61409",
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]
},
{
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{
"id": "Q61409",
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]
}
]
},
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{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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]
},
{
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"id": "Q61481",
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]
}
]
},
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{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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]
},
{
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{
"id": "Q62865",
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]
}
]
},
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{
"ec_number": "3.1.4.-",
"activity": "",
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"id": "Q63085",
"database": "UniProtKB",
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}
]
},
{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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]
},
{
"ec_number": "3.1.4.17",
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{
"id": "Q63085",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q63085"
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]
}
]
},
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{
"ec_number": "3.1.4.-",
"activity": "",
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"url": "https://www.uniprot.org/uniprot/Q63421"
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]
},
{
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]
},
{
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"id": "Q63421",
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]
}
]
},
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{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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]
},
{
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{
"id": "Q64338",
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]
}
]
},
{
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{
"ec_number": "2.3.2.27",
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{
"id": "Q7Z6E9",
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]
},
{
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"evidence": [
{
"id": "Q7Z6E9",
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]
}
]
},
{
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{
"ec_number": "3.1.4.-",
"activity": "",
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{
"id": "Q8CA95",
"database": "UniProtKB",
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]
},
{
"ec_number": "3.1.4.17",
"activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).",
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{
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]
},
{
"ec_number": "3.1.4.17",
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{
"id": "Q8CA95",
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]
}
]
},
{
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{
"ec_number": "3.1.4.-",
"activity": "",
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{
"id": "Q8CG03",
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]
},
{
"ec_number": "3.1.4.35",
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{
"id": "Q8CG03",
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]
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