{
"uniprot_canonical_ac": "O75976-1",
"uniprot_ac": "O75976",
"uniprot_id": "CBPD_HUMAN",
"mass": {
"chemical_mass": 152931.0,
"monoisotopic_mass": 152931.0
},
"refseq": {
"ac": "NP_001186704",
"name": "carboxypeptidase D isoform 2",
"summary": "The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
},
"gene_names": [
{
"name": "CPD",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O75976",
"id": "O75976"
},
{
"name": "CPD",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704",
"id": "NP_001186704"
},
{
"name": "GP180",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704",
"id": "NP_001186704"
}
],
"protein_names": [
{
"name": "Carboxypeptidase D",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O75976"
},
{
"name": "3.4.17.22",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75976"
},
{
"name": "Metallocarboxypeptidase D",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75976"
},
{
"name": "carboxypeptidase D isoform 2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704",
"id": "NP_001186704"
},
{
"name": "gp180",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75976"
},
{
"name": "metallocarboxypeptidase D",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704",
"id": "NP_001186704"
}
],
"function": [
{
"annotation": "CPD immunostaining and testosterone/prolactin-stimulated CPD expression were higher in prostate cancer than benign tissues/cells. Elevated CPD increased NO production, which was abolished when both androgen and prolactin receptors were inhibited.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
},
{
"database": "PubMed",
"id": "24615730",
"url": "https://glygen.org/publication/PubMed/24615730"
}
]
},
{
"annotation": "Carboxypeptidase-D (CPD) overexpression coincides with high-grade lung cancer and the CPD overexpression could reverse the inhibitory effects of miR-214",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
},
{
"database": "PubMed",
"id": "27494742",
"url": "https://glygen.org/publication/PubMed/27494742"
}
]
},
{
"annotation": "Prolactin and R1881, acting through Stat5 and androgen receptor, act cooperatively to stimulate CPD gene transcription in breast cancer cells.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
},
{
"database": "PubMed",
"id": "24433040",
"url": "https://glygen.org/publication/PubMed/24433040"
}
]
},
{
"annotation": "Prolactin induction of VEGF-C and Runx2 was inhibited partly by Carboxypeptidase-D inhibitors, implicating nitric oxide , produced by PRL-regulated Carboxypeptidase-D, in breast cancer progression",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
},
{
"database": "PubMed",
"id": "28364216",
"url": "https://glygen.org/publication/PubMed/28364216"
}
]
},
{
"annotation": "The human carboxypeptidase D transthyretin-like domain forms amyloid under physiological conditions.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
},
{
"database": "PubMed",
"id": "25294878",
"url": "https://glygen.org/publication/PubMed/25294878"
}
]
},
{
"annotation": "The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "rs745350591",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745350591"
},
{
"id": "rs745350591",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745350591"
},
{
"id": "rs745350591",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs745350591"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"n-glyco-sequon-gain"
],
"start_pos": 410,
"end_pos": 410,
"sequence_org": "N",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NIT->SIT); n-glyco-sequon-gain (NHN->NHS).",
"chr_id": "17",
"chr_pos": "30421755",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N410",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs372336205",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372336205"
},
{
"id": "rs372336205",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372336205"
},
{
"id": "rs372336205",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs372336205#frequency_tab"
},
{
"id": "rs372336205",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs372336205"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 628,
"end_pos": 628,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNS->NNN); o-glyco-site-loss (S->N).",
"chr_id": "17",
"chr_pos": "30427424",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S628",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs558201013",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs558201013"
},
{
"id": "rs558201013",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs558201013"
},
{
"id": "rs558201013",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs558201013"
},
{
"id": "rs558201013",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs558201013"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1071,
"end_pos": 1071,
"sequence_org": "A",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNA->NNS).",
"chr_id": "17",
"chr_pos": "30455344",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "0.0002",
"site_lbl": "A1071",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs558201013",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs558201013"
},
{
"id": "rs558201013",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs558201013"
},
{
"id": "rs558201013",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs558201013"
},
{
"id": "rs558201013",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs558201013"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1071,
"end_pos": 1071,
"sequence_org": "A",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNA->NNT).",
"chr_id": "17",
"chr_pos": "30455344",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "0.0002",
"site_lbl": "A1071",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "O75976",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75976"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 1072,
"end_pos": 1072,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "S",
"sequence_mut": "P",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NAS->NAP).",
"chr_id": "17",
"chr_pos": "30455347",
"ref_nt": "T",
"alt_nt": "C",
"minor_allelic_frequency": "",
"site_lbl": "S1072",
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs777580072",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777580072"
},
{
"id": "rs777580072",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777580072"
},
{
"id": "rs777580072",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs777580072#frequency_tab"
},
{
"id": "rs777580072",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs777580072"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 1142,
"end_pos": 1142,
"sequence_org": "N",
"sequence_mut": "D",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NKS->DKS).",
"chr_id": "17",
"chr_pos": "30456342",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N1142",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs777580072",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777580072"
},
{
"id": "rs777580072",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs777580072"
},
{
"id": "rs777580072",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs777580072#frequency_tab"
},
{
"id": "rs777580072",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs777580072"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 1142,
"end_pos": 1142,
"sequence_org": "N",
"sequence_mut": "Y",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NKS->YKS).",
"chr_id": "17",
"chr_pos": "30456342",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N1142",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs779144998",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779144998"
},
{
"id": "rs779144998",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779144998"
},
{
"id": "rs779144998",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs779144998#frequency_tab"
},
{
"id": "rs779144998",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs779144998"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 1366,
"end_pos": 1366,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DET->NET).",
"chr_id": "17",
"chr_pos": "30464767",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D1366",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1460795208",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1460795208"
},
{
"id": "rs1460795208",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1460795208"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 172,
"end_pos": 172,
"sequence_org": "N",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->TTT).",
"chr_id": "17",
"chr_pos": "30379495",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N172",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs370241648",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370241648"
},
{
"id": "rs370241648",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370241648"
},
{
"id": "rs370241648",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs370241648#frequency_tab"
},
{
"id": "rs370241648",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs370241648"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 174,
"end_pos": 174,
"sequence_org": "T",
"sequence_mut": "I",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->NTI).",
"chr_id": "17",
"chr_pos": "30379501",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "T174",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1434725968",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1434725968"
},
{
"id": "rs1434725968",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1434725968#frequency_tab"
},
{
"id": "rs1434725968",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1434725968"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 217,
"end_pos": 217,
"sequence_org": "N",
"sequence_mut": "I",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRS->IRS).",
"chr_id": "17",
"chr_pos": "30379630",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N217",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1434725968",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1434725968"
},
{
"id": "rs1434725968",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1434725968#frequency_tab"
},
{
"id": "rs1434725968",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1434725968"
}
],
"glycoeffect": [
"n-glyco-sequon-loss"
],
"start_pos": 217,
"end_pos": 217,
"sequence_org": "N",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRS->SRS).",
"chr_id": "17",
"chr_pos": "30379630",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N217",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs755815841",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755815841"
},
{
"id": "rs755815841",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755815841"
},
{
"id": "rs755815841",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs755815841"
}
],
"glycoeffect": [
"n-glyco-sequon-loss",
"o-glyco-site-loss"
],
"start_pos": 219,
"end_pos": 219,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRS->NRN).",
"chr_id": "17",
"chr_pos": "30379636",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S219",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs753491322",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753491322"
},
{
"id": "rs753491322",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs753491322"
},
{
"id": "rs753491322",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs753491322#frequency_tab"
},
{
"id": "rs753491322",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs753491322"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 226,
"end_pos": 226,
"sequence_org": "T",
"sequence_mut": "A",
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"o-glyco-site-loss"
],
"start_pos": 980,
"end_pos": 980,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "S",
"sequence_mut": "F",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NVS->NVF).",
"chr_id": "17",
"chr_pos": "30449618",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "S980",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
}
],
"mutagenesis": [],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "87.24",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "87.33",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "93.72",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "69.46",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "83.76",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "90.08",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "83",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "84.5",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "83.52",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "89.61",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "94.43",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "81.94",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "84.86",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000108582",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000108582"
}
]
}
],
"expression_disease": [
{
"significant": "No",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
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{
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{
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{
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"resource": "MONDO",
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"name": "gastric cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
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"name": "gastric neoplasm",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
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},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
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{
"database": "BioXpress",
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"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
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],
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},
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},
{
"id": "DOID:11054",
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"name": "tumor of the bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
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},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
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},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
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"id": "O75976",
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}
],
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{
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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},
{
"id": "DOID:11934",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
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{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
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],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
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},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
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"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "O75976",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75976"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
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"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11308",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "CHEMBL4523154",
"url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4523154",
"database": "ChEMBL",
"categories": [
"Other"
]
},
{
"id": "CPD",
"url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CPD",
"database": "GeneCards",
"categories": [
"Gene Annotation",
"Organism-specific"
]
},
{
"id": "1362",
"url": "https://www.ncbi.nlm.nih.gov/gene/1362",
"database": "GeneID",
"categories": [
"Genome Annotation"
]
},
{
"id": "1066",
"url": "https://glyconnect.expasy.org/browser/proteins/1066",
"database": "GlyConnect",
"categories": [
"Glycoproteomics",
"Glycan"
]
},
{
"id": "2301",
"url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2301",
"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "O75976",
"url": "https://www.ebi.ac.uk/intact/interactors/id:O75976*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR000834",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000834",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR008969",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR008969",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR033848",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR033848",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR034224",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR034224",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:1362",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1362",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "603102",
"url": "http://www.omim.org/entry/603102",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_O75976",
"url": "https://www.nextprot.org/entry/NX_O75976",
"database": "neXtProt",
"categories": [
"Protein",
"Organism-specific"
]
},
{
"id": "O75976",
"url": "https://oglcnac.org/atlas/detail/O75976",
"database": "O-GlcNAc Atlas",
"categories": [
"Glycoproteomics"
]
},
{
"id": "O75976",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75976",
"database": "O-GlcNAc Database",
"categories": [
"Glycoproteomics"
]
},
{
"id": "QAAHIKK",
"url": "https://omabrowser.org/oma/group/QAAHIKK/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "5490979at2759",
"url": "http://www.orthodb.org/?query=5490979at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR11532",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11532",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR11532:SF73",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11532:SF73",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "5AQ0",
"url": "https://www.rcsb.org/structure/5AQ0",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00246",
"url": "http://pfam.xfam.org/family/PF00246",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF13620",
"url": "http://pfam.xfam.org/family/PF13620",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "O75976",
"url": "https://pharos.nih.gov/targets/O75976",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR:000050865",
"url": "https://proconsortium.org/app/entry/PR:000050865",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050866",
"url": "https://proconsortium.org/app/entry/PR:000050866",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050867",
"url": "https://proconsortium.org/app/entry/PR:000050867",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050868",
"url": "https://proconsortium.org/app/entry/PR:000050868",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050869",
"url": "https://proconsortium.org/app/entry/PR:000050869",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050870",
"url": "https://proconsortium.org/app/entry/PR:000050870",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050871",
"url": "https://proconsortium.org/app/entry/PR:000050871",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050872",
"url": "https://proconsortium.org/app/entry/PR:000050872",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050873",
"url": "https://proconsortium.org/app/entry/PR:000050873",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050874",
"url": "https://proconsortium.org/app/entry/PR:000050874",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050875",
"url": "https://proconsortium.org/app/entry/PR:000050875",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050876",
"url": "https://proconsortium.org/app/entry/PR:000050876",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050877",
"url": "https://proconsortium.org/app/entry/PR:000050877",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050878",
"url": "https://proconsortium.org/app/entry/PR:000050878",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050879",
"url": "https://proconsortium.org/app/entry/PR:000050879",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR:000050880",
"url": "https://proconsortium.org/app/entry/PR:000050880",
"database": "PRO",
"categories": [
"Glycoproteomics"
]
},
{
"id": "PR_O75976",
"url": "http://purl.obolibrary.org/obo/PR_O75976",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-432722",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-432722",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9696264",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9696273",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696273",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_001186704",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186704",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "O75976",
"url": "DISABLED",
"database": "UniCarbKB",
"categories": [
"Glycoproteomics"
]
},
{
"id": "J3QQJ4",
"url": "https://www.uniprot.org/uniprot/J3QQJ4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "J3QQJ4-1",
"url": "https://www.uniprot.org/uniprot/J3QQJ4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "J3QRJ9",
"url": "https://www.uniprot.org/uniprot/J3QRJ9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "J3QRJ9-1",
"url": "https://www.uniprot.org/uniprot/J3QRJ9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "K7ELF0",
"url": "https://www.uniprot.org/uniprot/K7ELF0",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "K7ELF0-1",
"url": "https://www.uniprot.org/uniprot/K7ELF0-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O75976-1",
"url": "https://www.uniprot.org/uniprot/O75976-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O75976-2",
"url": "https://www.uniprot.org/uniprot/O75976-2",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH",
"length": 1380,
"header": "sp|O75976-1|CBPD_HUMAN Isoform 1 of Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=2 CANONICAL=O75976-1"
},
"isoforms": [
{
"isoform_ac": "J3QQJ4-1",
"url": "",
"sequence": {
"sequence": "VHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGPKNLLLSSQIVFYIH",
"length": 184,
"header": "tr|J3QQJ4-1|CBPD_HUMAN Computationally mapped isoform of Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=2 CANONICAL=O75976-1"
},
"locus": {
"chromosome": "17",
"start_pos": 30466295,
"end_pos": 30443802,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000584221.2",
"url": "https://www.ensembl.org/id/ENST00000584221.2"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000463763.2",
"url": "https://www.ensembl.org/id/ENSP00000463763.2"
}
]
}
},
{
"isoform_ac": "J3QRJ9-1",
"url": "",
"sequence": {
"sequence": "NARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMVLW",
"length": 82,
"header": "tr|J3QRJ9-1|CBPD_HUMAN Computationally mapped isoform of Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=1 CANONICAL=O75976-1"
},
"locus": {
"chromosome": "17",
"start_pos": 30462403,
"end_pos": 30451810,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000579502.1",
"url": "https://www.ensembl.org/id/ENST00000579502.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000464255.1",
"url": "https://www.ensembl.org/id/ENSP00000464255.1"
}
]
}
},
{
"isoform_ac": "K7ELF0-1",
"url": "",
"sequence": {
"sequence": "XVGTELLLALAEFLCLNYKKNPAVTQMGERELKRKTVLQK",
"length": 40,
"header": "tr|K7ELF0-1|CBPD_HUMAN Computationally mapped isoform of Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=1 CANONICAL=O75976-1"
},
"locus": {
"chromosome": "17",
"start_pos": 30451800,
"end_pos": 30449673,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000584050.6",
"url": "https://www.ensembl.org/id/ENST00000584050.6"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000466049.1",
"url": "https://www.ensembl.org/id/ENSP00000466049.1"
}
]
}
},
{
"isoform_ac": "O75976-1",
"url": "",
"sequence": {
"sequence": "MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVEGRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH",
"length": 1380,
"header": "sp|O75976-1|CBPD_HUMAN Isoform 1 of Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=2 CANONICAL=O75976-1"
},
"locus": {
"chromosome": "17",
"start_pos": 30464811,
"end_pos": 30378981,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000225719.9",
"url": "https://www.ensembl.org/id/ENST00000225719.9"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000225719.4",
"url": "https://www.ensembl.org/id/ENSP00000225719.4"
}
]
}
},
{
"isoform_ac": "O75976-2",
"url": "",
"sequence": {
"sequence": "MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPLEKELPNFWEQNRRSLIQFMKQVHQGVRGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAIQVNFTLVRSSTDSNNESKKGKGASSSTNDASDPTTKEFETLIKDLSAENGLESLMLRSSSNLALALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSTEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSMLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAARLPSLWADNKRSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVQTKEGGYFHVLLAPGVHNIIAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH",
"length": 1133,
"header": "sp|O75976-2|CBPD_HUMAN Isoform 2 of Carboxypeptidase D OS=Homo sapiens OX=9606 GN=CPD PE=1 SV=2 CANONICAL=O75976-1"
},
"locus": {
"chromosome": "17",
"start_pos": 30464811,
"end_pos": 30380638,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000543464.6",
"url": "https://www.ensembl.org/id/ENST00000543464.6"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000444443.2",
"url": "https://www.ensembl.org/id/ENSP00000444443.2"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "",
"type": "N-linked",
"subtype": "",
"site_category": "reported",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 1069,
"start_aa": "Asn",
"end_pos": 1069,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn1069",
"evidence": [
{
"id": "24190977",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/24190977"
},
{
"id": "GLY_000143",
"database": "GlyGen",
"url": "https://data.glygen.org/GLY_000143"
}
]
},
{
"glytoucan_ac": "G06110VR",
"type": "N-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "N",
"relation": "attached",
"comment": "",
"start_pos": 1070,
"start_aa": "Asn",
"end_pos": 1070,
"end_aa": "Asn",
"residue": "Asn",
"site_lbl": "Asn1070",
"evidence": [
{
"id": "1066",
"database": "GlyConnect",
"url": "https://glyconnect.expasy.org/browser/proteins/1066"
},
{
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"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"reference": [
{
"type": "PubMed",
"id": "9714835",
"url": "https://glygen.org/publication/PubMed/9714835"
}
]
}
],
"pathway": [
{
"id": "hsa:1362",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1362",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-432722",
"name": "Golgi Associated Vesicle Biogenesis",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-432722",
"resource": "Reactome",
"description": "Golgi Associated Vesicle Biogenesis"
},
{
"id": "R-HSA-9696264",
"name": "RND3 GTPase cycle",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696264",
"resource": "Reactome",
"description": "RND3 GTPase cycle"
},
{
"id": "R-HSA-9696273",
"name": "RND1 GTPase cycle",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696273",
"resource": "Reactome",
"description": "RND1 GTPase cycle"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "F1RN68-1",
"protein_name": "Carboxypeptidase D",
"gene_name": "CPD",
"tax_id": 9823,
"organism": "Sus scrofa",
"sequence": {
"sequence": "MASGWDARPPWRRGRLPLLMCLLLLLRSPVQAAHIKKAEATTTTTSAGAEADEGQFDRYYHEEELGSVLREAAAAGPPGLARLFSIGSSVEGRPLWVLRLTAGLGPPPPDGDTGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYVLPSLNPDGFERAREGDCGLSDSGPPGASGRDNSRGRDLNRSFPDQFSTGEPPSLDDVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGAPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLKQEWENNRESLITLIEKVHIGVKGFVKDSVTGAGLENATISVAGISHNITTGRFGDFHRLLVPGTYNITVVSTGYMPLTINNIIVKEGPAAIVNFSLRPTVASLIPAATEVVVTASTVAILNSALGTQSSHQPVQPQDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVLNTRIHLMPSMNPDGYEKAQEGDSISVIGRNNSNNFDLNRNFPDQFIQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCIKYPFEKDLPKFWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATISVAEINHPVTTYKTGDYWRLLVPGTYKITASARGYNPVTKNVTVKSEGAVQVNFTLVRSSTDSNNESKKGKGDSTNADDASDPTTKEFETLIKDLSAENGLEGFILRTSSNLALYRYHSYKDLSEFLRGLVMNYPHITNLTNLGQSAEYRHIWSLEISNKPNVSEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPAVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKIGQTNARGKDLDTDFTNNASQPETKAIIENLIQKQDFSLSVALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNKSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLPSLWAENKKSLLSMLVEVHKGVHGFVKDKTGKPISKAVIVLNEGIKVHTKEGGYFHVLLAPGVHNINAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH",
"length": 1374
},
"evidence": [
{
"id": "O75976",
"url": "https://omabrowser.org/oma/group/O75976/",
"database": "OMA"
}
],
"common_name": "Pig"
},
{
"uniprot_canonical_ac": "O89001-1",
"protein_name": "Carboxypeptidase D",
"gene_name": "Cpd",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MASGRDERPPWRLGRLRLLPPPPLLLLLLLLRSSAQAAHIKKAEATTTTVGGSEAAEGQFDHYYHEAALGEALEAAAAAGPPGLARLFSIGSSVEGRPLWVLRLTAGLGPPPTAAAGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSLDEVPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTGLYSKTSDDEVFRYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHNITTGRFGDFHRLLVPGTYNLTALSTGYMPLTINNIMVKEGPATEMDFSLRPTVMSVMPGSTEAVTTPGTVAVPNIPPGTPSSHQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVRSTRIHLMPSMNPDGYEKSQEGDSISVVGRNNSNNFDLNRNFPDQFVPITEPTQPETIAVMSWVKAYPFVLSANLHGGSLVVNYPYDDNEQGVATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKDMYLNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFENELPKYWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATLSVAEINHPVTTYKAGDYWRLLVPGTYKITASARGYNPVTKNVTVRSEGAVQVNFTLVRSSADANNESKKGRGHSTSTDDTSDPTSKEFEALIKHLSAENGLEGFMLSSSSDLALYRYHSYKDLSEFLRGLVMNYPHITNLTTLGQSVEYRHIWSLEISNKPNISEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKRNPVVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKTGHTNAHGKDLDTDFTSNASQPETKAIIENLIQKQDFSLSIALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNNSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLPALWAENKKSLLSMLVEVHKGVHGLVKDKAGKPISKAVIVLNEGIKVYTKEGGYFHVLLAPGVHNINAIADGYQQQHTQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH",
"length": 1377
},
"evidence": [
{
"id": "45922315",
"url": "http://www.informatics.jax.org/homology/45922315",
"database": "MGI"
},
{
"id": "O75976",
"url": "https://omabrowser.org/oma/group/O75976/",
"database": "OMA"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q9JHW1-1",
"protein_name": "Carboxypeptidase D",
"gene_name": "Cpd",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MASGWDERPPWRLESLRLLPPPPLLLLLLLLRSSAQAAHIKKAEATTTTVGGSEAAEGQFDHYYHEAALGEALEAAAAAGPPGLARLFSIGNSVEGRPLWVLRLTAGLGPPPTPAAVGLDAAGPLLPGRPQVKLVGNMHGDETVSRQVLVYLARELASGYRRGDPRLVRLLNTTDVYLLPSLNPDGFERAREGDCGLGDSGPPGTSGRDNSRGRDLNRSFPDQFSTGEPPSLDEVPEVRALIDWIRRNKFVLSGNLHGGSVVASYPFDDSPEHKTTGIYSKTSDDEVFRYLAKAYASNHPIMRTGEPHCPGDEEETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGIKGFVKDSVTGSGLENATISVAGINHNITTGRFGDFHRLLIPGSYNLTAVSPGYMPLTINNIVVKEGPATEIDFSLQPTVMSVVPDSTEAVTTPGTVAVPNIPPGTPSSHQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVRSTRIHLMPSMNPDGYEKSQEGDSISVVGRNNSNNFDLNRNFPDQFVPITDPTQPETIAVMSWVKAYPFVLSANLHGGSLVVNYPYDDNEQGVATYSKSPDDAVFQQIALSYSKENSQMFQGRPCKDMYLNEYFPHGITNGASWYNVPGGMQDWNYLQTNCFEVTIELGCVKYPFEKELPKYWEQNRRSLIQFMKQVHQGVKGFVLDATDGRGILNATLSVAEINHPVTTYKAGDYWRLLVPGTYKITASARGYNPVTKNVTVRSEGAIQVNFTLVRSSTDANNESKKGKGHSTSTDDTSDPTSKEFEALIKHLSAENGLEGFMLSSSSDLALYRYHSYKDLSEFLRGLVMNYPHITNLTTLGQSVEYRHIWSLEISNKPNISEPEEPKIRFVAGIHGNAPVGTELLLALAEFLCLNYKKNPVVTQLVDRTRIVIVPSLNPDGRERAQEKDCTSKTGHTNARGRDLDTDFTSNASQPETKAIIENLIQKQDFSLSIALDGGSVLVTYPYDKPVQTVENKETLKHLASLYANNHPSMHMGQPSCPNNSDENIPGGVMRGAEWHSHLGSMKDYSVTYGHCPEITVYTSCCYFPSAAQLPALWAENKKSLLSMLVEVHKGVHGLVKDKTGKPISKAVIVLNEGIRVHTKEGGYFHVLLAPGVHNINAIADGYQQQHSQVFVHHDAASSVVIVFDTDNRIFGLPRELVVTVSGATMSALILTACIIWCICSIKSNRHKDGFHRLRQHHDEYEDEIRMMSTGSKKSLLSHEFQDETDTEEETLYSSKH",
"length": 1378
},
"evidence": [
{
"id": "45922315",
"url": "http://www.informatics.jax.org/homology/45922315",
"database": "MGI"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Biological Process",
"total": 3,
"go_terms": [
{
"name": "proteolysis",
"id": "GO:0006508",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "protein processing",
"id": "GO:0016485",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "peptide metabolic process",
"id": "GO:0006518",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006518",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 3,
"go_terms": [
{
"name": "zinc ion binding",
"id": "GO:0008270",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "metallocarboxypeptidase activity",
"id": "GO:0004181",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004181",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "serine-type carboxypeptidase activity",
"id": "GO:0004185",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004185",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 4,
"go_terms": [
{
"name": "extracellular space",
"id": "GO:0005615",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "membrane",
"id": "GO:0016020",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
},
{
"name": "extracellular exosome",
"id": "GO:0070062",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062",
"evidence": [
{
"database": "UniProtKB",
"id": "O75976",
"url": "https://www.uniprot.org/uniprot/O75976"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [
{
"name": "carboxypeptidase D O-glycosylated 1 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Ser-45 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Ser-45, MOD:00002~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050865",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050865"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 2 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-226 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-226, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050866",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050866"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 3 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-40 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-40, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050867",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050867"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 4 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-40 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O75976-1, Thr-40, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050868",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050868"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 5 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-41 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-41, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050869",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050869"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 6 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-41 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O75976-1, Thr-41, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050870",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050870"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 7 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-42 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-42, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050871",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050871"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 8 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-42 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O75976-1, Thr-42, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050872",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050872"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 9 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-43 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-43, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050873",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050873"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 10 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-43 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G57317CE. Example: UniProtKB:O75976-1, Thr-43, MOD:00005~GNO:G57317CE. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050874",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050874"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 11 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-44 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-44, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050875",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050875"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 12 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-44 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O75976-1, Thr-44, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050876",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050876"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 13 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-489 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:O75976-1, Thr-489, MOD:00005~GNO:G29068FM. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050877",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050877"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 14 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-489 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75976-1, Thr-489, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050878",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050878"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 15 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-489 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:O75976-1, Thr-489, MOD:00005~GNO:G53434XO. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050879",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050879"
}
]
},
{
"name": "carboxypeptidase D O-glycosylated 16 (human)",
"definition": "A carboxypeptidase D (human) that has been O-glycosylated at the residue equivalent to Thr-489 of the amino acid sequence represented by UniProtKB:O75976-1, in which the glycan composition is represented by GlyTouCan:G58001LT. Example: UniProtKB:O75976-1, Thr-489, MOD:00005~GNO:G58001LT. [PRO:DNx, PMID:30459171]",
"evidence": [
{
"id": "PR:000050880",
"database": "PRO",
"url": "https://proconsortium.org/app/entry/PR:000050880"
}
]
}
],
"site_annotation": [
{
"start_pos": 1070,
"end_pos": 1072,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 1142,
"end_pos": 1144,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 172,
"end_pos": 174,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 217,
"end_pos": 219,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 399,
"end_pos": 401,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 410,
"end_pos": 412,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 429,
"end_pos": 431,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 522,
"end_pos": 524,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 626,
"end_pos": 628,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 811,
"end_pos": 813,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 855,
"end_pos": 857,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 867,
"end_pos": 869,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 879,
"end_pos": 881,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 955,
"end_pos": 957,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 978,
"end_pos": 980,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [],
"interactions": [],
"reactions": [
{
"id": "R-HSA-421831",
"name": "trans-Golgi Network Coat Assembly",
"equation": "",
"summary": "Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the vesicle. The number of clathrin triskelions required to sculpt a vesicle appears to be variable, but has been estimated to require 36 - 60 triskelions assocaited with 30 - 66 AP-1 complexes. Here a ~380 angstroms vesicle is represented with 48 clathrin triskelions and 52 AP-1 complexes.",
"cellular_location": "Golgi membrane, cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P51148-1",
"O00443-1",
"P50570-1",
"P84077-1",
"O14976-1",
"Q01968-1",
"O75976-1"
],
"evidence": [
{
"id": "R-HSA-421831",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-421831"
}
]
},
{
"id": "R-HSA-421833",
"name": "Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture",
"equation": "",
"summary": "Once AP-1 is recruited to the trans-Golgi Network membrane the complex of functional vesicle building proteins is joined by the cargo that will be within that vesicle. As with other types of vesicles the cargo itself is part of the vesicle development. Here the cargo is destined for the Golgi-associated vesicle membrane. It is at this stage that a specific Synaptobrevin (Vamp) molecule also joins the complex. It should be noted that only certain Vamp molecules will be found with specific cargo molecules on the newly forming vesicles. However here we represent this reaction in bulk, without specific Vamp and cargo molecule pairings.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P51148-1",
"O00443-1",
"P84077-1",
"O14976-1",
"Q01968-1",
"O75976-1"
],
"evidence": [
{
"id": "R-HSA-421833",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-421833"
}
]
},
{
"id": "R-HSA-421835",
"name": "trans-Golgi Network Vesicle Scission",
"equation": "",
"summary": "Dynamin is recruited to the growing vesicle and, under conditions that interfere with its GTPase activity, dynamin forms a collar or ring around the neck of the budding vesicle. It is unclear whether dynamin acts as a mechanochemical transducer to generate fission or as a recruiter to attach other proteins that are directly responsible for the fission step. Lipid-modifying enzymes such as endophilin are also involved in vesicle formation. Endophilin is an acyltransferase that interacts with dynamin and that generates lysophosphatidic acid. The current view is that this reaction produces a negative curvature at the neck of the vesicle.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P51148-1",
"O00443-1",
"P50570-1",
"O14976-1",
"Q01968-1",
"O75976-1"
],
"evidence": [
{
"id": "R-HSA-421835",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-421835"
}
]
},
{
"id": "R-HSA-421836",
"name": "trans-Golgi Network Derived Vesicle Uncoating",
"equation": "",
"summary": "The heat shock protein Hsc70 and auxilin, a J-domain containing protein, are responsible for clathrin disassembly through an ATP-dependent reaction. This uncoating step may be a point in the pathway subject to regulation. This final step releases the vesicle from the clathrin cage. The vesicle still contatins a specific Vamp molecule, part of the targeting and fusion mechanism that delivers the vesicle to its ultimate destination. This vesicle also contains its cargo, membrane proteins embeded in the Golgi-associated vesicle membrane.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P51148-1",
"O00443-1",
"P11142-1",
"O14976-1",
"Q01968-1",
"O75976-1",
"O75061-1"
],
"evidence": [
{
"id": "R-HSA-421836",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-421836"
}
]
},
{
"id": "R-HSA-9696268",
"name": "RND3 binds effectors",
"equation": "",
"summary": "Active GTP bound RND3 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagci et al. 2020)
KCTD13 (Gladwyn Ng et al. 2016)
PLEKHG5 (Goh and Manser 2010)
ROCK1 (Riento et al. 2003) RND3 inhibits kinase activity of ROCK1
TNFAIP1 (Gladwyn Ng et al. 2016)
UBXN11 (Katoh et al. 2002)
The following candidate RND3 effectors were reported in the high throughput screen by Bagci et al. 2020 or were reported by some but not all studies:
ANKRD26 (Bagci et al. 2020)
ARHGAP21 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003: binding to active RND3; Bagci et al. 2020: no binding to active RND3)
CAV1 (Bagci et al. 2020)
CCDC88A (Bagci et al. 2020)
CKAP4 (Bagci et al. 2020)
CKB (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020) - RND3 has not been shown to localize to the endoplasmic reticulum membrane, but some isoforms of KTN1 have been shown to localize to the plasma membrane (Santama et al. 2004)
LEMD3 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
PICALM (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
RND3 does not interact with the following effectors:
ALDH3A2 (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2003)
GOLGA3 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
ROCK2 (Riento et al. 2003)
RRAS2 (Bagci et al. 2020)
STMN2 (Li et al. 2009)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"P12277-1",
"Q12923-1",
"O75976-1",
"P29317-1",
"Q9NQI0-1"
],
"evidence": [
{
"id": "R-HSA-9696268",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696268"
}
]
},
{
"id": "R-HSA-9696271",
"name": "RND1 binds effectors",
"equation": "",
"summary": "Active GTP-bound RND1 binds the following effectors:
ARHGAP5 (Wennerberg et al. 2003; Bagci et al. 2020)
FRS2 (Harada et al. 2005)
FRS3 (Harada et al. 2005)
GRB7 (Vayssiere et al. 2000)
PLEKHG5 (Goh and Manser 2010)
PLXNA1 (Zanata et al. 2002)
STIP1 (de Souza et al. 2014)
STMN2 (Li et al. 2009)
UBXN11 (Katoh et al. 2002)
The following candidate RND1 effectors were reported in the high throughput screen by Bagci et al. 2020 or have been reported as RND1 effectors in some but not all studies:
ALDH3A2 (Bagci et al. 2020)
ANKRD26 (Bagci et al. 2020)
ARHGAP35 (Wennerberg et al. 2003, Mori et al. 2009: binding to active RND1; Bagci et al. 2020: no binding to active RND1)
CAV1 (Bagci et al. 2020)
CCDC88A (Bagci et al. 2020)
CPD (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DSP (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
EPSTI1 (Bagci et al. 2020)
FAM135A (Bagci et al. 2020)
FAM83B (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
KIDINS220 (Bagci et al. 2020)
KIF14 (Bagci et al. 2020)
LEMD3 (Bagci et al. 2020)
MUC13 (Bagci et al. 2020)
PKP4 (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
PTPN13 (Bagci et al. 2020)
RASAL2 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
RRAS2 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VANGL2 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
RND1 does not interact with the following putative effectors that bind to active RND2 and/or RND3:
CKAP4 (Bagci et al. 2020)
CKB (Bagci et al. 2020)
DDX4 (Bagci et al. 2020)
DSG1 (Bagci et al. 2020)
FNBP1 (Bagci et al. 2020)
GOLGA3 (Bagci et al. 2020)
KTN1 (Bagci et al. 2020)
LRRC1 (Bagci et al. 2020)
NISCH (Bagci et al. 2020)
NUDC (Bagci et al. 2020)
PICALM (Bagci et al. 2020)
SCRIB (Bagci et al. 2020)
SEMA4F (Bagci et al. 2020)
TMOD3 (Bagci et al. 2020)
UHRF1BP1L (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P51648-1",
"P62070-1",
"Q12923-1",
"O75976-1",
"P29317-1"
],
"evidence": [
{
"id": "R-HSA-9696271",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9696271"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "O00443",
"gene_name": "PIK3C2A",
"activity": [
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "O00443",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O00443"
}
]
}
]
},
{
"uniprot_ac": "O14976",
"gene_name": "GAK",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "O14976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14976"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "O14976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O14976"
}
]
}
]
},
{
"uniprot_ac": "O75061",
"gene_name": "DNAJC6",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "O75061",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75061"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "O75061",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75061"
}
]
}
]
},
{
"uniprot_ac": "O75976",
"gene_name": "CPD",
"activity": [
{
"ec_number": "3.4.17.22",
"activity": "Releases C-terminal Arg and Lys from polypeptides.",
"evidence": [
{
"id": "O75976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75976"
}
]
},
{
"ec_number": "3.4.17.22",
"activity": "",
"evidence": [
{
"id": "O75976",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O75976"
}
]
}
]
},
{
"uniprot_ac": "P11142",
"gene_name": "HSPA8",
"activity": [
{
"ec_number": "3.6.4.10",
"activity": "ATP + H2O = ADP + H(+) + phosphate.",
"evidence": [
{
"id": "P11142",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11142"
}
]
},
{
"ec_number": "3.6.4.10",
"activity": "",
"evidence": [
{
"id": "P11142",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P11142"
}
]
}
]
},
{
"uniprot_ac": "P12277",
"gene_name": "CKB",
"activity": [
{
"ec_number": "2.7.3.2",
"activity": "ATP + creatine = ADP + H(+) + N-phosphocreatine.",
"evidence": [
{
"id": "P12277",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12277"
}
]
},
{
"ec_number": "2.7.3.2",
"activity": "",
"evidence": [
{
"id": "P12277",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12277"
}
]
}
]
},
{
"uniprot_ac": "P29317",
"gene_name": "EPHA2",
"activity": [
{
"ec_number": "2.7.10.1",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P29317",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29317"
}
]
},
{
"ec_number": "2.7.10.1",
"activity": "",
"evidence": [
{
"id": "P29317",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P29317"
}
]
}
]
},
{
"uniprot_ac": "P50570",
"gene_name": "DNM2",
"activity": [
{
"ec_number": "3.6.5.5",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P50570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50570"
}
]
},
{
"ec_number": "3.6.5.5",
"activity": "",
"evidence": [
{
"id": "P50570",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P50570"
}
]
}
]
},
{
"uniprot_ac": "P51148",
"gene_name": "RAB5C",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P51148",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51148"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P51148",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51148"
}
]
}
]
},
{
"uniprot_ac": "P51648",
"gene_name": "ALDH3A2",
"activity": [
{
"ec_number": "1.2.1.3",
"activity": "an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH.",
"evidence": [
{
"id": "P51648",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51648"
}
]
},
{
"ec_number": "1.2.1.94",
"activity": "(2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH.",
"evidence": [
{
"id": "P51648",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51648"
}
]
},
{
"ec_number": "1.2.1.94",
"activity": "",
"evidence": [
{
"id": "P51648",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51648"
}
]
},
{
"ec_number": "1.2.1.3",
"activity": "",
"evidence": [
{
"id": "P51648",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P51648"
}
]
}
]
},
{
"uniprot_ac": "P62070",
"gene_name": "RRAS2",
"activity": [
{
"ec_number": "3.6.5.-",
"activity": "",
"evidence": [
{
"id": "P62070",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P62070"
}
]
}
]
},
{
"uniprot_ac": "P84077",
"gene_name": "ARF1",
"activity": [
{
"ec_number": "3.6.5.2",
"activity": "GTP + H2O = GDP + H(+) + phosphate.",
"evidence": [
{
"id": "P84077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P84077"
}
]
},
{
"ec_number": "3.6.5.2",
"activity": "",
"evidence": [
{
"id": "P84077",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P84077"
}
]
}
]
},
{
"uniprot_ac": "Q01968",
"gene_name": "OCRL",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
}
]
},
{
"uniprot_ac": "Q12923",
"gene_name": "PTPN13",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q12923",
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